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Emerging evidence has implicated nicotinamide adenine dinucleotide (NAD+) metabolism in various inflammatory diseases. In the study, the role of NAD+ metabolism in Complete Freund's Adjuvant (CFA)‐evoked inflammatory pain and the underlying mechanisms are investigated. The study demonstrated that CFA induced upregulation of nicotinamide phosphoribosyltransferase (NAMPT) in dorsal root ganglia (DRG) without significant changes in the spinal cord. Inhibition of NAMPT expression by intrathecal injection of NAMPT siRNA alleviated CFA‐induced pain‐like behavior, decreased NAD+ contents in DRG, and lowered poly‐(ADP‐ribose) polymerase 1 (PARP1) activity levels. These effects are all reversed by the supplement of nicotinamide mononucleotide (NMN). Inhibition of PARP1 expression by intrathecal injection of PARP1 siRNA alleviated CFA‐induced pain‐like behavior, while elevated NAD+ levels of DRG. The analgesic effect of inhibiting NAMPT/NAD+/PARP1 axis can be attributed to the downregulation of the NF‐κB/IL‐1β inflammatory pathway. Double immunofluorescence staining showed that the expression of NAMPT/NAD+/PARP1 axis is restricted to DRG neurons. In conclusion, PARP1 activation in response to CFA stimulation, fueled by NAMPT‐derived NAD+, mediates CFA‐induced inflammatory pain through NF‐κB/IL‐1β inflammatory pathway. [ABSTRACT FROM AUTHOR]

Cone beam computed tomography (CBCT) is widely employed in modern dentistry, and tooth segmentation constitutes an integral part of the digital workflow based on these imaging data. Previous methodologies rely heavily on manual segmentation and are time-consuming and labor-intensive in clinical practice. Recently, with advancements in computer vision technology, scholars have conducted in-depth research, proposing various fast and accurate tooth segmentation methods. In this review, we review 55 articles in this field and discuss the effectiveness, advantages, and disadvantages of each approach. In addition to simple classification and discussion, this review aims to reveal how tooth segmentation methods can be improved by the application and refinement of existing image segmentation algorithms to solve problems such as irregular morphology and fuzzy boundaries of teeth. It is assumed that with the optimization of these methods, manual operation will be reduced, and greater accuracy and robustness in tooth segmentation will be achieved. Finally, we highlight the challenges that still exist in this field and provide prospects for future directions. [ABSTRACT FROM AUTHOR]

Methanol steam reforming (MSR) provides an alternative way for efficient production and safe transportation of hydrogen but requires harsh conditions and complicated purification processes. In this work, an efficient electrochemical‐assisted MSR reaction for pure H2 production at lower temperature (~140 °C) is developed by coupling the electrocatalysis reaction into the MSR in a polymer electrolyte membrane electrolysis reactor. By electrochemically assisted, the two critical steps including the methanol dehydrogenation and water‐gas shift reaction are accelerated, which is attributed to decreasing the methanol dehydrogenation energy and promoting the dissociation of H2O to OH* by the applied potential. Furthermore, the reduced H2 partial pressure by the hydrogen oxidation and reduction process further promotes MSR. The combination of these advantages not only efficiently decreases the MSR temperature but also achieves the high rate of hydrogen production of 505 mmol H2 g Pt−1 h−1 with exceptionally high H2 selectivity (99 %) at 180 °C and a low voltage (0.4 V), and the productivity is about 30‐fold than that of traditional MSR. This study opens up a new avenue to design novel electrolysis cells for hydrogen production. [ABSTRACT FROM AUTHOR]

Studying the interaction between solar flares and sunspot groups (SGs) is crucial for understanding and predicting solar activity. We examined the distribution, correlation, and flaring rates in the northern and southern hemispheres to reveal the relationship between different classes of soft X-ray (SXR) flares and different magnetic classifications of SGs. We discovered a significant north–south asymmetry in SXR flares and SG distribution over Solar Cycles (SC) 21–25. In the rising phase of SC24, the northern hemisphere's activity is significantly excessive. In the declining phase of SC24, the southern hemisphere's activity becomes significantly excessive. The total numbers of various SXR flares and SGs vary between the northern and southern hemispheres over the solar cycle. B-class flares are negatively correlated with all SGs at maximum but positively correlated at minimum. C-class flares correlate best with α and β SGs. M-class flares correlate best with β γ δ and β SGs. X-class flares correlate highest with β γ δ SGs. The flaring rate of each flare class is lowest for α SGs and highest for β γ δ SGs. The flaring rates are higher in the southern hemisphere than in the northern hemisphere. Our results demonstrate that solar flares originate from different sources of solar active regions; the high-energy flares tend to be caused by more complex magnetic fields. [ABSTRACT FROM AUTHOR]