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Compared to integrated large screen displays, the splicing scheme that uses multiple display units for splicing has significant advantages in various aspects to achieve large screen displays. This article is based on MLCD (Mini LCD) display scheme that combines LCD and LED, and proposes various algorithms to improve the image quality of the splicing. It effectively solves the image quality problems that occur in MLCD display schemes, while taking into account the advantages of cost and maintenance, it can also fully leverage the image quality advantages. The splicing image quality improvement algorithm not only fills the gap in display effect improvement methods in the splicing display field, but also provides new ideas for the development of large screen image quality improvement technology. [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of articular cartilage. A challenge in the development of disease-modifying drugs is effective delivery to chondrocytes. The unique structure of the joint promotes rapid clearance of drugs through synovial fluid, and the dense and avascular cartilage extracellular matrix (ECM) limits drug penetration. Here, we show that poly(lactide-co-glycolic acid) nanoparticles coated in chondrocyte membranes (CM-NPs) were preferentially taken up by rat chondrocytes ex vivo compared with uncoated nanoparticles. Internalization of the CM-NPs was mediated primarily by E-cadherin, clathrin-mediated endocytosis, and micropinocytosis. These CM-NPs adhered to the cartilage ECM in rat knee joints in vivo and penetrated deeply into the cartilage matrix with a residence time of more than 34 days. Simulated synovial fluid clearance studies showed that CM-NPs loaded with a Wnt pathway inhibitor, adavivint (CM-NPs-Ada), delayed the catabolic metabolism of rat and human chondrocytes and cartilage explants under inflammatory conditions. In a surgical model of rat OA, drug-loaded CM-NPs effectively restored gait, attenuated periarticular bone remodeling, and provided chondroprotection against cartilage degeneration. OA progression was also mitigated by CM-NPs-Ada in a canine model of anterior cruciate ligament transection. These results demonstrate the feasibility of using chondrocyte membrane–coated nanoparticles to improve the pharmacokinetics and efficacy of anti-OA drugs. Editor's summary: Osteoarthritis (OA) lacks effective disease-modifying treatments partially because of the difficulty of delivering drugs to dense and avascular cartilage tissue. Here, Deng et al. disguised drug-carrying nanoparticles with chondrocyte membranes to increase the interaction of the nanoparticles with cartilage. These membrane-coated nanoparticles retained critical chondrocyte proteins that supported cell and matrix interactions in explanted rat and human cartilage. These nanoparticles were retained in rat knee in vivo for at least 34 days. In rat and canine models of injury-induced OA, release of a Wnt-pathway inhibitor from these nanoparticles improved cartilage and subchondral bone morphology. These findings support the further development of chondrocyte-mimicking particles for cartilage drug delivery and OA therapy. —Molly Ogle [ABSTRACT FROM AUTHOR]

Si3N4 is a promising material for heat dissipation substrate due to its excellent thermal conductivity and mechanical properties. However, its application is limited by the difficulties in surface metallization. In this work, surface metallization of Si3N4 ceramic substrate is realized by thick film method for the first time. Conductive silver paste containing Bi2O3-B2O3-ZnO glass frit as glass binder was prepared, and high-performance silver thick films were formed on Si3N4 ceramic surface. The mechanical and electrical properties of silver films were significantly promoted with increasing sintering temperature, and silver films with high shear strength of 23.35 MPa and low resistivity of 3.41 μΩ·cm were obtained when sintered at 600 °C. In the meanwhile, the silver films exist high reliability under thermal cycles. The bonding between the silver thick film and Si3N4 ceramic substrate was considerably enhanced as a result of interfacial reaction, forming Bi2Si2O5 phase at the interface during sintering process. The formation mechanism was discussed and it is of great significance for the interfacial design in future studies. The results suggest that thick film method is a promising technology for obtaining high-quality surface metallization for Si3N4 ceramic substrate. [ABSTRACT FROM AUTHOR]

Analogical reasoning is important for human. We have found that a short executive attention intervention improved analogical reasoning performance in healthy young adults. Nevertheless, previous electrophysiological evidence was limited for comprehensively characterizing the neural mechanisms underlying the improvement. And although we hypothesized that the intervention improved active inhibitory control and attention shift first and then relation integration, it is still unclear whether there are two sequential cognitive neural activities were indeed changed during analogical reasoning. In the present study, we combined hypothesis with multivariate pattern analysis (MVPA) to explore the effects of the intervention on electrophysiology. Results showed that in the resting state after the intervention, alpha and high gamma power and the functional connectivity between the anterior and middle in the alpha band could discriminate the experimental group from the active control group, respectively. These indicated that the intervention influenced the activity of multiple bands and the interaction of frontal and parietal regions. In the analogical reasoning, alpha, theta, and gamma activities could also fulfill such discrimination, and furthermore, they were sequential (alpha first, theta, and gamma later). These results directly supported our previous hypothesis. The present study deepens our understanding about how executive attention contributes to higher‐order cognition. [ABSTRACT FROM AUTHOR]

This article considers a federated temporal difference (TD) learning algorithm and provides both asymptotic and finite-time analyses. To protect each worker agent's cost information from being acquired by possible attackers, we propose a privacy-preserving variant of the algorithm by adding perturbation to the exchanged information. We show the rigorous differential privacy guarantee by using moments accountant and derive an upper bound of the utility loss for the privacy-preserving algorithm. Evaluations are also provided to corroborate the efficiency of the algorithms. [ABSTRACT FROM AUTHOR]

Although great progress has been made in engineered bone tissues, delayed or ineffective bone regeneration remains an issue due to the lack of neural network reconstruction in their design. Therefore, an engineered bone tissue construct that mimics the ossification center microenvironment to promote innervation is proposed. Based on this, the NGF@Lap constructs are constructed through bioprinting technology, which can release nerve growth factor (NGF) for a long time and simulate the ossification center's microenvironment with high expression NGF. In vitro, NGF@Lap‐GA can promote axonal extension. Meanwhile, the NGF and Laponite from the constructs can respectively promote the expression and secretion of calcitonin gene‐related peptide (CGRP) in sensory neurons. Further, the constructs show a CGRP‐dependent osteogenic and inhibition of adipogenesis, which is mainly regulated by AMP‐activated protein kinase‐peroxisome proliferator activated receptor pathway. In vivo, the constructs increased neurovascular network density in the tissue surrounding the implant, promoted bone marrow mesenchymal stem cells osteogenic differentiation, and effectively improved bone regeneration in the cranial defect model. In conclusion, the novel tissue‐engineered bone simulates the ossification center microenvironment, promotes innervation, and has promising potential for future application in bone regeneration. [ABSTRACT FROM AUTHOR]