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Objective: Understanding the perspectives of behavioral weight loss (BWL) participants could inform whether, how, and for whom BWL should be offered. Method: All 126 participants in a clinical trial of BWL for adults with binge‐eating disorder (BED) and overweight/obesity were contacted about a qualitative study. 45 participants, 11 of whom had dropped out of the parent study, completed qualitative interviews. The interview guide was developed using data from a survey of providers who offer Health at Every Size and other weight‐neutral lifestyle interventions. Questions were phrased to invite even the most negative responses. Questions focused on participants' experiences of weight stigma during treatment, perceptions of BWL's calorie and WL goals, and opinions of BWL and weight‐neutral interventions. Results: We identified four themes using thematic analysis: (1) BWL did not perpetuate weight stigma. (2) Calorie and WL goals did not exacerbate participants' binge eating. (3) Patients should have the right to pursue any treatment that aligns with their personal goals. (4) BWL can improve participants' overall health. Discussion: BWL participants with BED and overweight/obesity want others to have access to a program that can reduce both weight and binge eating. Participants emphasized that no treatment works for everyone, and they all agreed that BWL had not perpetuated weight stigma. Fewer than 20% of participants considered the program's calorie and WL goals to be harmful; most participants viewed those goals as achievable and helpful, and many asserted that their participation in BWL had improved their overall health. Public Significance: We interviewed adults with binge‐eating disorder and overweight/obesity who had participated in a behavioral weight loss (BWL) program. Our participants wanted others in their position to have access to BWL because it aims to reduce both weight and binge‐eating frequency. Efforts should be made to provide patients, clinicians, and policymakers with the knowledge that supervised, evidence‐based BWL is an effective and desired treatment choice for this population. [ABSTRACT FROM AUTHOR]

As gas wells enter later production stages, the formation pressure decreases and liquid accumulates at the bottom of the gas well. The formation pressure is insufficient to lift the accumulated liquid from the bottom of the well to the surface. At this time, a large number of gas wells need to undergo intermittent production to maintain their production capacity. This article focuses on the four stages of intermittent production in gas wells, considering the changes in slip gas holdup, pressure, and gas–liquid flow in and out of tubing and casing, and establishes a transient mathematical model for intermittent production in gas wells in stages. By using the dynamic tracking technology of moving liquid slugs to divide the wellbore grid and solve it in stages, the optimal shut-in time for intermittent production of gas wells was obtained. The transient mathematical model developed for intermittent gas well production achieved a high historical fit accuracy of over 90%. This indicates that the simulation results are in line with the actual situation of gas well intermittent production and can effectively guide intermittent production. The optimized intermittent production system of gas wells has a higher cumulative gas production compared to the original system, achieving the optimization of intermittent production system. This method is beneficial for guiding efficient production of gas wells in low-pressure formations. [ABSTRACT FROM AUTHOR]

As a euryhaline fish species that inhabits estuarine and coastal regions, the spotbanded scat (Selenotoca multifasciata) experiences growth influences during its larval stage due to variations in salinity. Here, we evaluated salinity required by early-stage spotbanded scat juveniles to achieve the highest growth performance, digestive enzyme activity, survival, and antioxidant capacity. We reared spotbanded scat juveniles (all 0.50 ± 0.05 g) in 0–35‰ salinity gradients for 50 days and recorded their survival rate every 10 days. After 50 experimental days, we measured morphological data, stomach and intestinal digestive enzyme activities, and liver antioxidant enzyme activities and malondialdehyde contents. In general, 5–15‰ salinity led to 100% survival. The 5‰ salinity group demonstrated the highest values for the following measures: final wet body weight; weight gain rate; specific growth rate; growth percentage; average daily gain; stomach amylase and lipase specific activities; and intestinal amylase, lipase, trypsin, and pepsin specific activities. However, stomach trypsin and pepsin activities did not demonstrate significant between-group differences (all p > 0.05). The 25‰ salinity group demonstrated the highest liver superoxide dismutase and glutathione peroxidase activities and malondialdehyde content. Finally, the 0‰ salinity group demonstrated the highest liver catalase activity. Thus, spotbanded scat juveniles demonstrate the highest survival rates, growth performance, and digestive enzyme activity at 5‰ salinity and the strongest oxidative stress responses at 25‰ salinity. [ABSTRACT FROM AUTHOR]

Objective: Anxiety sensitivity (AS), the trait‐like fear of symptoms of anxiety, has been associated with eating disorder (ED) pathology broadly, bulimia nervosa (BN) symptoms specifically, and the anxiety disorders that are commonly comorbid with BN. AS, especially for physical symptoms specifically, maybe a risk and maintenance factor for BN and comorbid anxiety. Method: Adult participants with BN (n = 44) in a clinical trial comparing CBT to mindfulness and acceptance‐based treatment (MABT) reported ED symptoms, trait anxiety, and AS through treatment and follow‐up. We predicted that greater early reduction (i.e., within the first month of treatment) in AS would predict greater reductions in ED symptoms and trait anxiety at post‐treatment and follow‐up. Results: Early reductions in AS for physical concerns predicted lower ED symptoms and trait anxiety at post‐treatment but not follow‐up. Exploratory analyses indicated that treatment groups did not differ in either early or total change in AS, controlling for baseline AS. Discussion: Early reductions in AS may be an important treatment target for BN, and may additionally support reductions in anxiety. Future research should identify which components of CBT and MABT best target AS, to deliver these components early in treatment, when they can have maximum effect. Public Significance: Anxiety sensitivity, the fear of symptoms of anxiety, is associated with eating disorders (ED). In this study, participants in treatment for bulimia nervosa reported ED symptoms, trait anxiety, and anxiety sensitivity through treatment and follow‐up. Greater early reductions in anxiety sensitivity predicted lower ED symptoms and trait anxiety at post‐treatment. Future research should identify which elements of treatment best target anxiety sensitivity, to deliver them early in treatment. [ABSTRACT FROM AUTHOR]

Transition metal oxides (TMOs) exhibit fascinating physicochemical properties, which originate from the diverse coordination structures between the transition metal and oxygen atoms. Accurate determination of such structure-property relationships of TMOs requires to correlate structural and electronic properties by capturing the global parameters with high resolution in energy, real, and momentum spaces, but it is still challenging. Herein, we report the determination of characteristic electronic structures from diverse coordination environments on the prototypical anatase-TiO2(001) with (1 × 4) reconstruction, using high-resolution angle-resolved photoemission spectroscopy and scanning tunneling microscopy/atomic force microscopy, in combination with density functional theory calculation. We unveil that the shifted positions of O 2s and 2p levels and the gap-state Ti 3p levels can sensitively characterize the O and Ti coordination environments in the (1 × 4) reconstructed surface, which show distinguishable features from those in bulk. Our findings provide a paradigm to interrogate the intricate reconstruction-relevant properties in many other TMO surfaces.By measuring in energy, momentum and real space, the authors unveil diverse coordination environments and electronic structures on the reconstructed anatase TiO2(001), giving insights into its structure-property relationship with atomic precision. [ABSTRACT FROM AUTHOR]

Huobahua, namely, Tripterygium hypoglaucum (Levl.) Hutch, known as a traditional Chinese herbal medicine, especially its underground parts, has been widely developed into several Tripterygium agents for the treatment of rheumatoid arthritis and other autoimmune diseases. It has sparked wide public concern about its safety, such as multi‐organ toxicity. However, the toxic characteristics and damage mechanism of Huobahuagen extract (HBHGE) remain unclear. In the present study, subchronic oral toxicity study of HBHGE (10.0 g crude drug/kg/day for 12 weeks) was performed in male rats. Hematological, serum biochemical, and histopathological parameters, urinalysis, and plasma metabolic profiling were assessed. The single‐dose subchronic toxicity results related to HBHGE exhibited obvious toxicity to the testis and epididymis of male rats. Furthermore, plasma metabolomics analysis suggested that a series of metabolic disorders were induced by oral administration of HBHGE, mainly focusing on amino acid (glutamate, phenylalanine, and tryptophan) metabolisms, pyrimidine metabolism, glutathione metabolism, and steroid hormone biosynthesis. Moreover, it appeared that serum testosterone in male rats treated with HBHGE for 12 weeks, decreased significantly, and was susceptible to the toxic effects of HBHGE. Taken together, conventional pathology and plasma metabolomics for preliminarily exploring subchronic toxicity and underlying mechanism can provide useful information about the reduction of toxic risks from HBHGE and new insights into the development of detoxification preparations. Huobahua, as the representative of medicinal herb with both significant efficacy and potential toxicity, has attracted more attention in its safety. The present study showed obvious toxicity to the testis and epididymis of male rats induced by Huobahuagen extract (HBHGE), and the potential damage mechanism was associated with a series of metabolic disorders, mainly including amino acid (glutamate, phenylalanine, and tryptophan) metabolisms, pyrimidine metabolism, glutathione metabolism, and steroid hormone biosynthesis. [ABSTRACT FROM AUTHOR]