Search

Your search keyword '"Liu, Wenjin"' showing total 788 results
Start Over Author "Liu, Wenjin"
788 results on '"Liu, Wenjin"'

52. Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma.

Author

Yang, Xu, Lian, Baofeng, Zhang, Nan, Long, Junyu, Li, Yiran, Xue, Jingnan, Chen, Xiangqi, Wang, Yunchao, Wang, Yanyu, Xun, Ziyu, Piao, Mingjian, Zhu, Chenpei, Wang, Shanshan, Sun, Huishan, Song, Zhijian, Lu, Leilei, Dong, Xiaowei, Wang, Aodi, Liu, Wenjin, and Pan, Jie

Subjects
PROGRAMMED cell death 1 receptors, MICROSATELLITE repeats, CHOLANGIOCARCINOMA, IMMUNOTHERAPY, NUCLEOTIDE sequencing, PROGRAMMED death-ligand 1
Abstract

Background: Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role in the genomic features and immunotherapy in cholangiocarcinoma (CCA) is unclear. This study aimed to systematically investigate the genomic characterization and immunotherapy efficacy of MSI-H patients with CCA. Methods: We enrolled 887 patients with CCA in this study. Tumor samples were collected for next-generation sequencing. Differences in genomic alterations between the MSI-H and microsatellite stability (MSS) groups were analyzed. We also investigated the survival of PD-1 inhibitor-based immunotherapy between two groups of 139 patients with advanced CCA. Results: Differential genetic alterations between the MSI-H and MSS groups included mutations in ARID1A, ACVR2A, TGFBR2, KMT2D, RNF43, and PBRM1 which were enriched in MSI-H groups. Patients with an MSI-H status have a significantly higher tumor mutation burden (TMB) (median 41.7 vs. 3.1 muts/Mb, P < 0.001) and more positive programmed death ligand 1 (PD-L1) expression (37.5% vs. 11.9%, P < 0.001) than those with an MSS status. Among patients receiving PD-1 inhibitor-based therapy, those with MSI-H had a longer median overall survival (OS, hazard ratio (HR) = 0.17, P = 0.001) and progression-free survival (PFS, HR = 0.14, P < 0.001) than patients with MSS. Integrating MSI-H and PD-L1 expression status (combined positive score ≥ 5) could distinguish the efficacy of immunotherapy. Conclusions: MSI-H status was associated with a higher TMB value and more positive PD-L1 expression in CCA tumors. Moreover, in patients with advanced CCA who received PD-1 inhibitor-based immunotherapy, MSI-H and positive PD-L1 expression were associated with improved both OS and PFS. Trial registration: This study was registered on ClinicalTrials.gov on 07/01/2017 (NCT03892577). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

62. Supplementary Figures S1 - S10, Tables S1 - S3 from Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

Author

Burd, Christin E., primary, Liu, Wenjin, primary, Huynh, Minh V., primary, Waqas, Meriam A., primary, Gillahan, James E., primary, Clark, Kelly S., primary, Fu, Kailing, primary, Martin, Brit L., primary, Jeck, William R., primary, Souroullas, George P., primary, Darr, David B., primary, Zedek, Daniel C., primary, Miley, Michael J., primary, Baguley, Bruce C., primary, Campbell, Sharon L., primary, and Sharpless, Norman E., primary

Published
2023
Full Text
View/download PDF

63. Data from Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

Author

Burd, Christin E., primary, Liu, Wenjin, primary, Huynh, Minh V., primary, Waqas, Meriam A., primary, Gillahan, James E., primary, Clark, Kelly S., primary, Fu, Kailing, primary, Martin, Brit L., primary, Jeck, William R., primary, Souroullas, George P., primary, Darr, David B., primary, Zedek, Daniel C., primary, Miley, Michael J., primary, Baguley, Bruce C., primary, Campbell, Sharon L., primary, and Sharpless, Norman E., primary

Published
2023
Full Text
View/download PDF

64. Impacting factors and effects of college student learning satisfaction: a comparative study

Author

Liu, Wenjin, Yang, Yi, and Peng, Shenli

Abstract

This study conducted comparative analyses on impacting factors and effects of college student learning satisfaction between online and offline teaching mode. The results demonstrated that: 1) students' learning satisfaction for offline teaching mode was significantly higher than that for online mode; 2) teacher-student interaction, student-student interaction, course content and teacher quality were significantly positively correlated with both online and offline learning satisfaction, respectively. Furthermore, teacher-student interaction and student-student interaction positively predict offline learning satisfaction, while student-student interaction and teacher quality positively predict online learning satisfaction; 3) offline learning satisfaction significantly affected students' evaluation of learning outcomes as well as their preference of teaching mode. Specifically, the more satisfaction they had of offline teaching mode, the students were more likely to indicate the learning outcomes of offline courses was higher than that of online courses, and prefer to choose offline teaching mode as well as the blended teaching mode.

Published
2024
Full Text
View/download PDF

67. Ab initio study on the fast reversible phase transitions of Ge2Sb2Te5.

Author

Yang, Fei, Tao, Yue, Zhang, Le, Han, Junnan, Cao, Xincheng, Zhuo, Zhenguo, Zhu, Ziyue, Liu, Wenjin, and Dai, Yuehua

Subjects
REVERSIBLE phase transitions, BOND angles, PHASE transitions, MOLECULAR dynamics, ABSORPTION coefficients, ATOMIC structure
Abstract

Ge2Sb2Te5 (GST) alloy has the ability to quickly transform between the amorphous phase and the crystalline phase; therefore, it can be used in non-volatile phase change storage. First-principles molecular dynamics was used to simulate the reversible phase change process of GST alloy, namely, amorphization and crystallization. The amorphous state was obtained by melting (∼3000 K) and cooling, and the amorphization process was characterized by the pair correlation function and bond angle distribution. The bond angles of amorphous GST were mainly distributed around 60°, 90°, and 110°, indicating the existence of octahedral and tetrahedral bonding configurations. The crystalline state was obtained by annealing at a temperature of 600 K, and the crystallization process was characterized by the pair correlation function, component disordered number, bond angle distribution, and dynamic atomic structure change. The results show that the bond angle of GST in crystallization is mainly distributed around 90°, and the structure mainly contains four-membered rings formed by Ge–Te and Sb–Te. By analyzing the optical properties, with the growth of crystallization time, the absorption coefficient, reflectivity, and conductivity of GST were significantly improved. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

72. Corrigendum to “Intracranial vascular feature changes in time of flight MR angiography in patients undergoing carotid revascularization surgery” [Magn. Reson. Imaging, 75, Jan 2021, 45–50]

Author

Chen, Zhensen, primary, Chen, Li, additional, Shirakawa, Manabu, additional, Liu, Wenjin, additional, Ortega, Dakota, additional, Chen, Jinmei, additional, Balu, Niranjan, additional, Trouard, Theodore, additional, Hatsukami, Thomas S., additional, Zhou, Wei, additional, and Yuan, Chun, additional

Published
2023
Full Text
View/download PDF

93. Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer

Author

Kong, Yanjie, primary, Ren, Wenlong, additional, Fang, Huan, additional, Shah, Naseer Ali, additional, Shi, Yujie, additional, You, Dingyun, additional, Zhou, Chengang, additional, Jiang, Dewei, additional, Yang, Chuanyu, additional, Liang, Huichun, additional, Liu, Wenjin, additional, Wang, Luzhen, additional, Gan, Wenqiang, additional, Wan, Xing, additional, Li, Fubing, additional, Li, Zhen, additional, Chen, Ceshi, additional, and Xie, Ni, additional

Published
2022
Full Text
View/download PDF

94. Fabrication and characterization of PMMA/TiH2 energetic microcapsules with a hollow structure

Author

Yu‐Le Yao, Yuan Chen, Chen Tao, Yang-Fan Cheng, Liu Wenjin, Hua Fang, and Zhaowu Shen

Subjects
Pentane, chemistry.chemical_compound, Fabrication, Materials science, Physics and Astronomy (miscellaneous), chemistry, Chemical engineering, Emulsion explosive, Core (manufacturing), Methyl methacrylate, Characterization (materials science)
Abstract

Energetic hollow microcapsules (EHMs) were designed as dual-functional sensitizers for emulsion explosive with pentane/TiH2 and poly(methyl methacrylate) (PMMA) as core and shell, respectively. SEM...

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results