61 results on '"Ludwig, Leopold"'
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52. Chance für kleine Fachgruppen.
- Author
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Ludwig, Leopold and Merkt, Jürgen
- Published
- 2013
- Full Text
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53. Bi-allelic inactivation of the MEN1 tumor suppressor gene in human grade II astrocytoma☆
- Author
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Karges, Wolfram, Karges, Beate, Ludwig, Leopold, and Heidemann, Peter H.
- Subjects
- *
BRAIN tumors , *ASTROCYTOMAS - Abstract
In humans and gene-targeted mice, loss of multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene function causes neuroendocrine tumors, frequently of the parathyroid and pituitary glands and the pancreas. The MEN1 gene product interacts with glial fibrillary acidic protein (GFAP) in the brain. We here demonstrate bi-allelic MEN1 inactivation in a grade II astrocytoma in an individual carrying a heterozygous MEN1 germ line deletion mutation (788del6). This tumor represents a novel, non-endocrine MEN1-phenotype, compatible with a role of MEN1-GFAP in glial oncogenesis. Clinically, a genetic predisposition to variant neoplasias should be considered in the management of MEN1 patients. [Copyright &y& Elsevier]
- Published
- 2003
- Full Text
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54. Arias
- Author
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Wagner, Richard, 1813-1883., Philharmonia Orchestra (London, England) Performer, Nilsson, Birgit., Hotter, Hans., Ludwig, Leopold. Conductor, Wagner, Richard, 1813-1883. Tannhäuser. Dich, teure Halle., Wagner, Richard, 1813-1883. Fliegende Holländer. Jo-ho-hoe! Traft ihr das Schiff., Wagner, Richard, 1813-1883. Fliegende Holländer. Wie aus der Ferne., Wagner, Richard, 1813-1883. Lohengrin. Einsam in trüben Tagen., Wagner, Richard, 1813-1883. Ring des Nibelungen. Selections. Walküre., and Wagner, Richard, 1813-1883. Tristan und Isolde. Liebestod.
- Published
- 2008
55. The three sopranos.
- Author
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Bayerische Staatsoper München. Orchester. Performer, Opéra de Paris. Orchestre. Performer, Philharmonia Chorus (London, England) Performer, Philharmonia Orchestra (London, England) Performer, Radiodiffusion-Télévision française. Chœurs. Performer, Radiodiffusion-Télévision française. Orchestre national. Performer, Sinfonia of London. Performer, Teatro dell'opera (Rome, Italy). Coro. Performer, Teatro dell'opera (Rome, Italy). Orchestra. Performer, Angeles, Victoria de los., Beecham, Thomas, Sir, 1879-1961. Conductor, Böhm, Karl, 1894-1981. Conductor, Cluytens, André. Conductor, Frühbeck de Burgos, Rafael. Conductor, Giulini, Carlo Maria. Conductor, Heger, Robert. Conductor, Karajan, Herbert von. Conductor, Ludwig, Leopold. Conductor, Matačić, Lovro von. Conductor, Mehta, Zubin. Conductor, Molinari-Pradelli, Francesco. Conductor, Nilsson, Birgit., Santini, Gabriele, 1886-1964. Conductor, Schwarzkopf, Elisabeth., Bizet, Georges, 1838-1875. Carmen. Habanera., Gounod, Charles, 1818-1893. Faust. Je ris de me voir si belle., Lehár, Franz, 1870-1948. Lustige Witwe. Es lebt' eine Vilja., Luna, Pablo, 1879-1942. Niño judío. De España vengo., Mozart, Wolfgang Amadeus, 1756-1791. Operas. Selections., Puccini, Giacomo, 1858-1924. Operas. Selections., Strauss, Richard, 1864-1949. Rosenkavalier (Opera). Da geht er hin., Verdi, Giuseppe, 1813-1901. Aïda. Ritorna vincitor., Wagner, Richard, 1813-1883. Tristan und Isolde. Liebestod., and Weber, Carl Maria von, 1786-1826. Freischütz. Leise, leise, fromme Weise.
- Published
- 2007
56. Arie d'opera e lieder
- Author
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Norddeutscher Rundfunk. Sinfonie-Orchester, performer., RIAS-Symphonie-Orchester, performer., Mödl, Martha, performer., Schmidt-Isserstedt, Hans, 1900-1973, conductor., Sanzogno, Nino, conductor., Schüchter, Wilhelm, conductor., Ludwig, Leopold, conductor., Hartig, Heinz-Friedrich, performer., Raucheisen, Michael, 1889-1984, performer., Container of (work): Purcell, Henry, 1659-1695. Dido and Aeneas. When I am laid in earth. German., Container of (work): Handel, George Frideric, 1685-1759. Rodelinda. Dove sei? amato bene!, Container of (work): Handel, George Frideric, 1685-1759. Giulio Cesare. V'adoro, pupille. German., Container of (work): Gluck, Christoph Willibald, Ritter von, 1714-1787. Alceste (1776). Divinités du Styx. German., Container of (work): Gluck, Christoph Willibald, Ritter von, 1714-1787. Orfeo ed Euridice. Che farò senza Euridice. German., Container of (work): Mussorgsky, Modest Petrovich, 1839-1881. Boris Godunov (1872). Arii︠a︡ Mariny. German., Container of (work): Mussorgsky, Modest Petrovich, 1839-1881. Boris Godunov (Rimsky-Korsakov). Duet (Act 3). German., Container of (work): Rimsky-Korsakov, Nikolay, 1844-1908. Snegurochka. Khor t︠s︡vetov. German., Container of (work): Humperdinck, Engelbert, 1854-1921. Hänsel und Gretel. Suse, liebe Suse., Container of (work): Brahms, Johannes, 1833-1897. Gesänge, op. 43. Mainacht., Container of (work): Brahms, Johannes, 1833-1897. Lieder, op. 105. Wie Melodien zieht es mir., Container of (work): Brahms, Johannes, 1833-1897. Gesänge, op. 3. Liebestreu., and Container of (work): Brahms, Johannes, 1833-1897. Gedichte, op. 19. Schmied.
- Published
- 2006
57. Don Giovanni
- Author
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Mozart, Wolfgang Amadeus, 1756-1791, composer., Norddeutscher Rundfunk. Chor, performer., Norddeutscher Rundfunk. Sinfonie-Orchester, performer., Danco, Suzanne, performer., Martinis, Carla, performer., Hoffmann, Lore, 1911-1996, performer., Dermota, Anton, performer., Schöffler, Paul, 1897-1977, performer., Kunz, Erich, 1909-1995, performer., Hofmann, Ludwig, 1895-1963, performer., Neidlinger, Gustav, 1910-1991, performer., and Ludwig, Leopold, conductor.
- Published
- 2001
58. Piano concertos 4 & 5 'Emperor'
- Author
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Beethoven, Ludwig van, 1770-1827., Philharmonia Orchestra (London, England) Performer, Gilels, Emil. Performer, Ludwig, Leopold. Conductor, and Beethoven, Ludwig van, 1770-1827. Concertos, piano, orchestra, no. 5, op. 73,
- Published
- 2005
59. Should Screening Colonoscopy Be Offered From Age 50?
- Author
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Brenner H, Zwink N, Ludwig L, and Hoffmeister M
- Subjects
- Adenoma, Female, Germany, Humans, Male, Middle Aged, Postal Service, Colonoscopy, Colorectal Neoplasms diagnosis, Mass Screening
- Abstract
Background: The introduction of colonoscopic screening in 2002 for persons aged 55 and older was followed by a marked decline in the incidence of colon cancer in the corresponding age groups in Germany. The prevalence of colorectal neoplasia among persons aged 50 to 54 has remained unknown until now. Expert committees currently recommend colonoscopic screening for persons aged 50 and older. This option has been offered since 2014 by the AOK Baden-Württemberg and by Bosch BKK in the framework of their specialized medical care program., Methods: In April 2014 and 2015, 84 726 insurees aged 50-54 were invited by mail to participate in colonoscopic screening. The utilization and results of colonoscopic screening were studied. A questionnaire about risks was additionally sent to half of the participants, who were selected at random (study registration: DRKS00006268)., Results: Within one year, 1.9% of persons to whom invitations had been sent took up the offer of colonoscopic screening; these persons included 3.3% of those already enrolled in the specialized medical care program. The 1396 colonoscopies that were performed revealed advanced neoplasia (colon cancer or advanced adenoma) in 6.8% of cases. The prevalence of advanced neoplasia among men aged 50 to 54 was nearly twice as high as that among women in the same age group (8.6% vs. 4.5%, p = 0.0027). It was also higher than the prevalences documented in the German nationwide cancer registry for women aged 55 to 79. The additional sending of a risk questionnaire along with the invitation had no effect on the rate of detection of relevant findings or on the rate of participation in colonoscopic screening., Conclusion: These findings lend support to the demand that the offer of colonoscopic screening should be extended at least to men aged 50 and above.
- Published
- 2017
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60. [Colonoscopy screening from 50 -- A new era in Baden-Württemberg].
- Author
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Ludwig L
- Subjects
- Humans, Colonoscopy trends, Colorectal Neoplasms pathology, Colorectal Neoplasms prevention & control, Early Detection of Cancer trends
- Published
- 2015
- Full Text
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61. Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer.
- Author
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Liptay S, Weber CK, Ludwig L, Wagner M, Adler G, and Schmid RM
- Subjects
- Adenocarcinoma metabolism, Adenocarcinoma pathology, Cell Division, Cell Nucleus chemistry, ErbB Receptors genetics, ErbB Receptors metabolism, Fibroblasts chemistry, Humans, I-kappa B Kinase, I-kappa B Proteins genetics, I-kappa B Proteins metabolism, Mutation, NF-KappaB Inhibitor alpha, NF-kappa B analysis, NF-kappa B physiology, NF-kappa B p50 Subunit, Pancreatic Neoplasms pathology, Protein Serine-Threonine Kinases antagonists & inhibitors, Protein Serine-Threonine Kinases metabolism, Transcription Factor RelA, Tumor Cells, Cultured, ras Proteins genetics, ras Proteins physiology, Apoptosis, NF-kappa B metabolism, Pancreatic Neoplasms metabolism
- Abstract
The transcription factor NF-kappaB/Rel was found to be constitutively activated in human pancreatic cancer. RelA is present in the nucleus in primary human pancreatic cancer samples as well as in pancreatic cancer cell lines. NF-kappaB/Rel-binding activity consists of NF-kappaB1(p50) and RelA(p65). Constitutive NF-kappaB/Rel activity correlates with IkappaB kinase (IKK) activity and can be blocked by dominant negative mutants of IKKbeta and to a lesser extent by IKKalpha. Constitutive NF-kappaB/Rel activity and the transactivation potential of RelA(p65) can be inhibited by dominant negative mutant Ras, the PI3 kinase inhibitor LY294002, or dominant negative mutant Akt kinase. Transfection of a dominant negative mutant epidermal growth factor receptor (EGF-R), EGF-R kinase inhibitor Tyrphostin and LY 294002 blocked IKK activity and NF-kappaB-dependent transcription. Inhibition of constitutive IKK or NF-kappaB/Rel activity increased the number of apoptotic cells. Stably expressing a nondegradable form of IkappaBalpha inhibited anchorage-dependent and -independent proliferation in MiaPaCa2 and Panc1 cells. Our data demonstrate that an EGF-R/Ras/PI3 kinase/Akt/IKK-dependent pathway contributes to constitutive NF-kappaB/Rel activity in pancreatic cancer. Inhibition of NF-kappaB/Rel activity reveals a mitogenic and antiapoptotic role for NF-kappaB/Rel in pancreatic cancer., (Copyright 2003 Wiley-Liss, Inc.)
- Published
- 2003
- Full Text
- View/download PDF
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