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Your search keyword '"M. Rene Malinow"' showing total 55 results
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55 results on '"M. Rene Malinow"'

51. Diet-induced systemic lupus erythematosus (SLE) in primates

Author

Frank Parker, Bernard Pirofsky, Wilbur P. McNulty, Kirk D. Wuepper, M. Rene Malinow, Donald C. Houghton, and Emil J. Bardana

Subjects
medicine.medical_specialty, Counterimmunoelectrophoresis, Anti-nuclear antibody, Anemia, Neutrophils, Biopsy, Hematocrit, Kidney, Internal medicine, medicine, Animals, Lupus Erythematosus, Systemic, Lupus erythematosus, LE cell, medicine.diagnostic_test, biology, business.industry, DNA, medicine.disease, Diet, Titer, Coombs Test, Macaca fascicularis, Microscopy, Electron, Endocrinology, Nephrology, Antibodies, Antinuclear, biology.protein, Female, Antibody, business, Anti-SSA/Ro autoantibodies, Medicago sativa
Abstract

Ten adult, female cynomolgus macaques were randomly assigned to two equal groups: (1) semipurified diet (SPD); and (2) SPD with 45% ground alfalfa seed (AS). Both groups were studied at monthly intervals after 5 mo on their respective diets. Control animals had a mean hematocrit (Hct) of 43 +/- 2%, negative antiglobulin (AG), antinuclear antibody (ANA) and LE cell tests. Mean values for C3 and C4 were 309 +/- 47 mg/dl and 35 +/- 7 mg/dl, respectively. Mean serum binding to radiolabeled double stranded deoxyribonucleic acid (dsDNA) was 1.9 +/- 0.2%. Three of five animals fed AS developed signs of an SLE-like illness characterized by AG-positive anemia (lowest Hct 30%), positive ANA (highest titer greater than 1:15, 360; rim pattern) and elevated anti-dsDNA binding (highest 96%) with variable degrees of hypocomplementemia. One animal had granular deposition of immunoglobulin and complement at the dermal-epidermal junction of clinically normal skin the presence of immune complex-induced glomerulonephritis.

Published
1982

52. Atherosclerosis: progression, regression, and resolution

Author

M. Rene Malinow

Subjects
Male, Cellular membrane, Ischemic myocardium, Arteriosclerosis, Coronary Angiography, Iodinated contrast, medicine, Animals, Humans, Myocardial infarction, Tissue distribution, Aorta, business.industry, Arteries, Middle Aged, Sodium Diatrizoate, medicine.disease, Coronary Vessels, Lipids, Lipoproteins, LDL, Cholesterol, Serial imaging, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Lipoproteins, HDL, Canine model
Abstract

35. Wackers FJT, Becker AE, Samson G, Sokole EB, Van der Schoot JB, Vet AJTM, Lie KI, Durrer D, Wellens H: Location and size of acute transmural myocardial infarction estimated from thallium-201 scintiscans. A clinicopathological study. Circulation 56~72, 1977. Adams DF, Hessel SJ, Judy PF, Stein JA, Abrams HL: Differing attenuation coefficients of normal and infarcted myocardium. Science 192:467, 1976. Powell WJ, Wittenberg J, Miller SW, Maturi RA, Dinsmore RE: Assessment of drug intervention on the ischemic myocardium: Serial imaging and measurement with computerized tomography. Am J Cardiol 44:46, 1979. Powell WJ. Wittenbere J. Maturi RA. Dinsmore RE. Miller SW: Detection of edem; associated with myocardial i&hernia by computerized tomography in isolated, arrested canine hearts. Circulation 55:99, 1977. Wittenberg J, Powell WJ, Dinsmore RE, et al: Computerized tomography of ischemic myocardium: Quantitation of extent and severity of edema in an in vitro canine model. Invest Radio1 12:215, 1977. McChesney EW, Hoppe JO: Studies of the tissue distribution and excretion of sodium diatrizoate in laboratory animals. AJR 78:137, 1957. Abraham JL, Higgins CB, Newell JD: Uptake of iodinated contrast material in ischemic myocardium as an indicator of loss of cellular membrane integrity. Am J Path01 101:319, 1980. 36.

Published
1984

53. Effects of synthetic glycosides on cholesterol absorption

Author

M. Rene Malinow

Subjects
chemistry.chemical_classification, Male, Cholesterol, General Neuroscience, Hypercholesterolemia, Glycoside, Rats, Inbred Strains, Diosgenin, Saponins, General Biochemistry, Genetics and Molecular Biology, Rats, Cholesterol, Dietary, chemistry.chemical_compound, History and Philosophy of Science, Biochemistry, chemistry, Intestinal Absorption, Spirostans, Animals, Glycosides
Published
1985

54. Maculopathy in cynomolgus monkeys. A correlated fluorescein angiographic and ultrastructural study

Author

Martha Neuringer, M. Rene Malinow, Michael L. Klein, and Lynette Feeney-Burns

Subjects
medicine.medical_specialty, genetic structures, Biology, Drusen, Fundus (eye), Lipofuscin, Melanin, chemistry.chemical_compound, Macular Degeneration, Retinal Diseases, Ophthalmology, medicine, Animals, Macula Lutea, Fluorescein, Fluorescein Angiography, Pigment Epithelium of Eye, Retinal pigment epithelium, Anatomy, medicine.disease, eye diseases, Macaca fascicularis, Microscopy, Electron, medicine.anatomical_structure, chemistry, Ultrastructure, Maculopathy, sense organs
Abstract

• Maculae of seven cynomolgus macaque monkeys ( Macaca fascicularis ) showing abnormalities in color fundus photographs and fluorescein angiograms were studied in serial sections by light and electron microscopy and compared with three eyes without clinically visible defects in the macula. Maculae that showed hyperfluorescent nonleaking window defects showed no drusen or interruptions in the retinal pigment epithelium (RPE). Six of these monkeys had misshapen foveal depressions, all showed some degree of photoreceptor degeneration, and one had cells in Bruch's membrane. Bright yellow spots correlated with scattered RPE filled with lipid vacuoles. Shallow RPE elevations correlated with diffuse nonleaking window defects. Patches of RPE deficient in melanin occurred at sites of hyperfluorescence. Quantitative studies showed that maculae with window defects had more lipofuscin and less melanin per RPE cell. Maculae deemed normal by photography showed degenerating photoreceptors.

Published
1981

55. Plasma folate, vitamin B(12), and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women.

Author

Sanchez SE, Zhang C, Rene Malinow M, Ware-Jauregui S, Larrabure G, and Williams MA

Subjects
Adult, Case-Control Studies, Female, Humans, Logistic Models, Odds Ratio, Peru epidemiology, Pre-Eclampsia blood, Pre-Eclampsia etiology, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Surveys and Questionnaires, Folic Acid blood, Homocysteine blood, Hyperhomocysteinemia complications, Pre-Eclampsia epidemiology, Vitamin B 12 blood
Abstract

The authors measured maternal third trimester plasma folate, vitamin B(12), and homocyst(e)ine concentrations among 125 women with preeclampsia and 179 normotensive women in Lima, Peru (1997-1998), to determine whether these analytes were associated with the occurrence of preeclampsia. Logistic regression procedures were used to calculate maximum likelihood estimates of odds ratios and 95% confidence intervals. Relative to women in the upper quartile of the control distribution of maternal plasma folate concentrations, women with values in the lowest quartile experienced a 1.6-fold increased risk of preeclampsia (odds ratio = 1.6; 95% confidence interval: 0.8, 3.2). There was no evidence of an increased risk of preeclampsia associated with low plasma vitamin B(12) concentrations. The unadjusted relative risk of preeclampsia increased across successively higher quartiles of plasma homocyst(e)ine level (odds ratios were 1.0, 1.0, 1.5, and 2.9, respectively, with the lowest quartile used as the referent; p for linear trend = 0.0004). After adjustment for maternal age, parity, gestational age, use of prenatal vitamins, whether the pregnancy had been planned, and educational attainment, the relative risk between extreme quartiles was 4.0 (95% confidence interval: 1.8, 8.9). These findings are consistent with earlier reports suggesting that hyperhomocyst(e)inemia in pregnancy may be a risk factor for preeclampsia.

Published
2001
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