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822 results on '"MATSUMOTO, Masaru"'

54. Successful Treatment with Short-Term Steroid Against Severe Hepatitis Confirmed by Liver Biopsy in a Patient with Advanced Squamous-Cell Lung Cancer Receiving a Combination of Pembrolizumab, Carboplatin, and Nab-Paclitaxel: A Case Report

Author

Hayashi,Anna, Nakamichi,Shinji, Nakayama,Yukako, Nagano,Atsuhiro, Mikami,Erika, Takano,Natsuki, Tozuka,Takehiro, Matsumoto,Masaru, Miyanaga,Akihiko, Noro,Rintaro, Terasaki,Yasuhiro, Kubota,Kaoru, Seike,Masahiro, and Gemma,Akihiko

Subjects
OncoTargets and Therapy
Abstract

Anna Hayashi,1 Shinji Nakamichi,1 Yukako Nakayama,1 Atsuhiro Nagano,1 Erika Mikami,1 Natsuki Takano,1 Takehiro Tozuka,1 Masaru Matsumoto,1 Akihiko Miyanaga,1 Rintaro Noro,1 Yasuhiro Terasaki,2 Kaoru Kubota,1 Masahiro Seike,1 Akihiko Gemma1 1Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Bunkyo-ku, Japan; 2Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Bunkyo-ku, JapanCorrespondence: Anna Hayashi, Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Tokyo, Bunkyo-ku, 113-8603, Japan, Tel +81-3-3822-2131, Fax +81-3-5685-3075, Email k-anna@nms.ac.jpAbstract: Pembrolizumab is an immune checkpoint inhibitor (ICI) that targets programmed death-1. Although ICIs have shown efficacy in the treatment of lung cancer, they have also been reported to cause a variety of immune-related adverse events (irAEs). Hepatotoxicity is a known irAEs, but currently, there is not enough information on its pathological characteristics and treatment. We report the case of a 70-year-old man with advanced squamous-cell lung cancer who developed severe grade 4 hepatitis on day 8 after receiving carboplatin, nab-paclitaxel, and pembrolizumab as fourth-line therapy. We treated him with steroid therapy the day after a liver biopsy was performed to investigate his pathological features, which led to a rapid and remarkable improvement. Confirmation of immune-related hepatotoxicity by pathological findings allowed the early tapering and discontinuation of steroid therapy. Performing a liver biopsy and verifying histological characteristics are needed for successful treatment with short-term steroids when drug-induced hepatitis caused by anti-cancer therapy including pembrolizumab is considered.Keywords: combination immunotherapy, immune checkpoint inhibitor, immune-related adverse events, irAEs, hepatotoxicity, liver biopsy, short-term steroid

Published
2022

58. Japanese clinical practice guidelines for aspiration and pharyngeal residual assessment during eating and swallowing for nursing care

Author

Sugama, Junko, primary, Ishibasi, Miyuki, additional, Ota, Erika, additional, Kamakura, Yayoi, additional, Saitoh, Eiichi, additional, Sanada, Hiromi, additional, Nakayama, Takeo, additional, Nomura, Takeshi, additional, Yamada, Masako, additional, Nakagami, Gojiro, additional, Sato, Naoko, additional, Shibata, Seiko, additional, Hase, Takashi, additional, Fukada, Junko, additional, Miki, Tatsuto, additional, Arita, Mikiko, additional, Urai, Tamae, additional, Okawa, Yohei, additional, Kitamura, Aya, additional, Dai, Misako, additional, Takahashi, Toshiaki, additional, Tamai, Nao, additional, Tobita, Itoko, additional, Noguchi, Hiroshi, additional, Matsumoto, Masaru, additional, Miura, Yuka, additional, Mukai, Kanae, additional, Mugita, Yuko, additional, Yoshida, Mikako, additional, Kurachi, Masako, additional, Shirasaka, Takako, additional, and Yamane, Yukiko, additional

Published
2022
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59. Halocline Induced by Rainfall in Saline Water Ponds in the Tropics and Its Impact on Physical Water Quality

Author

Ozaki, Akinori, Kaewjantawee, Panitan, Thinh Nguyen Van, Matsumoto, Masaru, Ozaki, Akinori, Kaewjantawee, Panitan, Thinh Nguyen Van, and Matsumoto, Masaru

Abstract

In saline water ponds in the tropics, a halocline may occur due to rainfall, especially in the rainy season. The critical impacts of haloclines in saline water ponds are heat insulation and the obstruction of vertical mixing. Considering the water quality in saline water ponds, the appearance of a halocline could have an impact on its variation, as the pond water quality may be impacted by both heat insulation and the obstruction of vertical mixing. Especially in saline water ponds with the purpose of aquaculture production, the appearance of a halocline may lead to dangerous risks, such as physiological stress on aquaculture products, increases in pathogenic micro-organisms, and deterioration of water quality. In the present study, the impact of the appearance of a halocline on physical water qualities was investigated by analyzing continuous on-site observation data obtained in Thailand. It was found that, after the appearance of the halocline, the heat was stored in the lower high-salinity layer, due to the heat insulation effect of the halocline. Furthermore, the halocline was also suggested to have an impact on the transportation of turbidity and to change the DO (dissolved oxygen) distribution in the vertical direction. These results are expected to provide information for assessment of the risk in saline water ponds and to contribute to a new approach for understanding deterioration problems in saline water aquaculture ponds.

Published
2022

64. Standard versus low‐dose nab‐paclitaxel in previously treated patients with advanced non‐small cell lung cancer: A randomized phase II trial (JMTO LC14‐01).

Author

Takeuchi, Susumu, Kubota, Kaoru, Sugawara, Shunichi, Teramukai, Satoshi, Noro, Rintaro, Fujikawa, Kei, Hirose, Takashi, Atagi, Shinji, Minami, Seigo, Iida, Shinichiro, Kuraishi, Hiroshi, Aiba, Tomoiki, Minegishi, Yuji, Matsumoto, Masaru, Seike, Masahiro, Gemma, Akihiko, and Kawahara, Masaaki

Subjects
NON-small-cell lung carcinoma
Abstract

Background: Nab‐paclitaxel (nab‐PTX) has better transfer to tumor tissue than cremophor‐based paclitaxel. It suggests that the optimum dose of nab‐PTX might be lower than the dose and schedule that is widely used. We designed a randomized phase II trial to examine the clinical utility and safety of nab‐PTX in patients with previously treated advanced non‐small cell lung cancer (NSCLC). Methods: Patients were randomly allocated (1:1) to receive nab‐PTX monotherapy at 100 mg/m2 (group A) or 70 mg/m2 (group B). The primary endpoint was progression‐free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR), and adverse events (AEs). Results: Finally, 81 patients were randomized. Similar results were observed in both groups for PFS (3.75 vs. 3.71 months), OS (13.50 vs. 16.13 months), or ORR (20.5% vs. 23.1%). The incidences of grade 3 or worse AEs were 57.5% in group A and 41.5% in group B. The proportion of serious side effects was 10.0% in group A and 4.9% in group B. Conclusion: Both standard dose and low dose of nab‐PTX monotherapy are active for previously treated NSCLC patients with better safety profile. Therefore, nab‐PTX 70 mg/m2 dose and schedule in the trial would be a reasonable option. [ABSTRACT FROM AUTHOR]

Published
2023
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65. Efficacy of toothpaste containing Brazilian green propolis extracts with an optimal kaempferide/betuletol ratio for improving oral microbiota: A randomized, controlled, paired crossover study.

Author

Amano, Shigeru, Matsumoto, Masaru, Morimoto, Masanori, Kawamoto, Hirokazu, Takeshita, Fumiaki, Yasui, Toshikazu, and Sakagami, Hiroshi

Subjects
*PERIODONTAL disease prevention, *ANTI-inflammatory agents, *HIGH performance liquid chromatography, *TRADITIONAL medicine, *NUCLEAR magnetic resonance spectroscopy, *STATISTICAL sampling, *HUMAN microbiota, *TREATMENT effectiveness, *RANDOMIZED controlled trials, *IN vivo studies, *DESCRIPTIVE statistics, *PROPOLIS, *ANTI-infective agents, *DENTIFRICES, *DENTAL plaque, *ORAL health
Abstract

Propolis is a resinous substance collected by honeybees from various plant sources and has been used in traditional folk medicine for centuries. Propolis has various biological properties, including antibacterial, antiviral, anti-inflammatory, and anti-tumor properties. The use of propolis in oral health care is attributable to its antimicrobial and anti-inflammatory effects. However, limited evidence exists on the in vivo efficacy of propolis against periodontal pathogens. We aimed to evaluate the efficacy of Brazilian green propolis (BGP)-containing toothpaste for improving the oral environment and define its antibacterial compounds. Overall, 48 student volunteers aged 18–40 years (24 females and 24 males) were randomly categorized into the BGP and placebo groups. The BGP and placebo groups received toothpaste with and without BGP, respectively. After a baseline assessment, the plaque index (PI) score, gingival index (GI) score, and proportion of periodontal pathogens on the tongue surface were analyzed at 0, 1, and 2 weeks. Antibacterial compounds were identified using liquid-liquid partitioning, high-performance liquid chromatography purification, and nuclear magnetic resonance methods. The concentration of BGP in the toothpaste was set at 0.0347 w/v%. Compared with the placebo group, the BGP group demonstrated a reduction in the PI score (p < 0.05) but not in the GI score, as well as a reduction in Porphyromonas gingivalis (Pg)/Total bacteria (Tb), Fusobacterium nucleatum (Fn)/Tb, and Aggregatibacter actinomycetemcomitans (Aa)/Tb (p < 0.05) but not in Streptococcus salivalius /Tb. Effect sizes for Pg , Fn and Aa were 0.360, 0.556, and 0.164, respectively. The antibacterial compounds of the BGP-containing toothpaste included a mixture of kaempferide/betuletol. We confirmed the efficacy of propolis toothpaste with an optimal kaempferide/betuletol ratio for improving oral microbiota, thereby suggesting that BGP toothpaste is clinically useful in maintaining oral health and preventing periodontal disease. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2025
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68. Expert Consensus Document: Diagnosis for Chronic Constipation with Faecal Retention in the Rectum Using Ultrasonography

Author

Matsumoto, Masaru, primary, Misawa, Noboru, additional, Tsuda, Momoko, additional, Manabe, Noriaki, additional, Kessoku, Takaomi, additional, Tamai, Nao, additional, Kawamoto, Atsuo, additional, Sugama, Junko, additional, Tanaka, Hideko, additional, Kato, Mototsugu, additional, Haruma, Ken, additional, Sanada, Hiromi, additional, and Nakajima, Atsushi, additional

Published
2022
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69. A Randomized Phase Ii Trial of Standard Versus Low-Dose Nab-Paclitaxel for Previously Treated Advanced Non-Small Cell Cancer: JMTO LC14-01

Author

Takeuchi, Susumu, primary, Kubota, Kaoru, additional, Sugawara, Shunichi, additional, Teramukai, Satoshi, additional, Noro, Rintaro, additional, Fujikawa, Kei, additional, Hirose, Takashi, additional, Atagi, Shinji, additional, Minami, Seigo, additional, Iida, Shinichiro, additional, Kuraishi, Hiroshi, additional, Aiba, Tomoiki, additional, Minegishi, Yuji, additional, Matsumoto, Masaru, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, and Kawahara, Masaaki, additional

Published
2022
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70. Efficacy with Trastuzumab Deruxtecan for Non-Small-Cell Lung Cancer Harboring HER2 Exon 20 Insertion Mutation in a Patient with a Poor Performance Status: A Case Report

Author

Kato,Yuki, Kato,Yasuhiro, Minegishi,Yuji, Suzuki,Takahiro, Nakamichi,Shinji, Matsumoto,Masaru, Miyanaga,Akihiko, Noro,Rintaro, Kubota,Kaoru, Terasaki,Yasuhiro, Seike,Masahiro, and Gemma,Akihiko

Subjects
OncoTargets and Therapy
Abstract

Yuki Kato,1 Yasuhiro Kato,1 Yuji Minegishi,1,2 Takahiro Suzuki,1 Shinji Nakamichi,1 Masaru Matsumoto,1 Akihiko Miyanaga,1 Rintaro Noro,1 Kaoru Kubota,1 Yasuhiro Terasaki,3 Masahiro Seike,1 Akihiko Gemma1 1Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan; 2Department of Pulmonary Medicine, Mitsui Memorial Hospital, Tokyo, Japan; 3Department of Analytic Human Pathology, Nippon Medical School, Tokyo, JapanCorrespondence: Yasuhiro KatoDepartment of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Sendagi 1-1-5 Bunkyo-ku, Tokyo, 113-8603, JapanEmail y-kato@nms.ac.jpAbstract: Antibody–drug conjugate (ADC) was novel type of anticancer drugs. Trastuzumab deruxtecan (T-DXd), a human epidermal growth factor receptor 2 (HER2) targeting ADC, can be a novel treatment option for HER2 alternation (mutation, expression, amplification) advanced-stage non-small-cell lung cancer (NSCLC) from DESTINY-Lung01 result. Herein, we report a successful treatment with T-DXd for NSCLC harboring HER2 exon 20 insertion mutation in a patient with poor performance status (PS). We presented a case of a 52-year-old heavily pretreated female patient diagnosed with lung adenocarcinoma (cT1bN3M0, stage IIIB). After fifth-line pretreatment of systemic chemotherapy, primary tumor recurrence, pleural effusion, and miliary lung metastases were observed. The patient presented with hypoxia requiring oxygen therapy via nasal cannula at a flow rate of 4 L per minute, cancer pain, and cachexia requiring opioid treatment. Her Eastern Cooperative Oncology Group PS score was assessed 3. Comprehensive genomic profiling revealed HER2 exon 20 insertion mutation. After treatment with T-DXd was approved by the ethical review committee of Nippon Medical School Hospital, treatment was started. The tumor size decreased significantly, and her PS score decreased from 3 to 1, with improvement of hypoxia, cancer pain, and cachexia. The patient is still receiving treatment, without disease progression 6 months after starting treatment with T-DXd. Despite cases of poor PS, NGS should be performed and target therapy including ADCs should be considered.Keywords: lung cancer, HER2 exon 20 insertion mutation, poor PS, trastuzumab deruxtecan

Published
2021

79. Evaluation of a Tool that Enables Cancer Patients to Participate in the Decision-Making Process during Treatment Selection

Author

Chubachi, Kumi, primary, Umihara, Junko, additional, Yoshikawa, Akiko, additional, Nakamichi, Shinji, additional, Takeuchi, Susumu, additional, Matsumoto, Masaru, additional, Miyanaga, Akihiko, additional, Minegishi, Yuji, additional, Yamamoto, Kazuo, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, and Kubota, Kaoru, additional

Published
2021
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80. Development of an Automatic Ultrasound Image Classification System for Pressure Injury Based on Deep Learning

Author

Matsumoto, Masaru, primary, Karube, Mikihiko, additional, Nakagami, Gojiro, additional, Kitamura, Aya, additional, Tamai, Nao, additional, Miura, Yuka, additional, Kawamoto, Atsuo, additional, Kurita, Masakazu, additional, Miyake, Tomomi, additional, Hayashi, Chieko, additional, Kawasaki, Akiko, additional, and Sanada, Hiromi, additional

Published
2021
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87. PD-L1 Expression Status Predicting Survival in Pulmonary Pleomorphic Carcinoma

Author

HISAKANE, KAKERU, primary, SEIKE, MASAHIRO, additional, SUGANO, TEPPEI, additional, MATSUDA, KUNIKO, additional, KUNUGI, SHINOBU, additional, NAKAMICHI, SHINJI, additional, MATSUMOTO, MASARU, additional, MIYANAGA, AKIHIKO, additional, NORO, RINTARO, additional, MINEGISHI, YUJI, additional, KUBOTA, KAORU, additional, and GEMMA, AKIHIKO, additional

Published
2021
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88. Long Non-Coding RNA CRNDE Is Involved in Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutant Lung Cancer via eIF4A3/MUC1/EGFR Signaling

Author

Takahashi, Satoshi, primary, Noro, Rintaro, additional, Seike, Masahiro, additional, Zeng, Chao, additional, Matsumoto, Masaru, additional, Yoshikawa, Akiko, additional, Nakamichi, Shinji, additional, Sugano, Teppei, additional, Hirao, Mariko, additional, Matsuda, Kuniko, additional, Hamada, Michiaki, additional, and Gemma, Akihiko, additional

Published
2021
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89. Diagnostic accuracy of ultrasound examination in detecting aspiration and pharyngeal residue in patients with dysphagia: A systematic review and meta‐analysis

Author

Miura, Yuka, primary, Tamai, Nao, additional, Kitamura, Aya, additional, Yoshida, Mikako, additional, Takahashi, Toshiaki, additional, Mugita, Yuko, additional, Tobita, Itoko, additional, Arita, Mikiko, additional, Urai, Tamae, additional, Dai, Misako, additional, Noguchi, Hiroshi, additional, Matsumoto, Masaru, additional, Mukai, Kanae, additional, Nakagami, Gojiro, additional, Ota, Erika, additional, Sugama, Junko, additional, and Sanada, Hiromi, additional

Published
2021
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97. Randomized Phase II Trial of Standard Versus Low-Dose Nab-Paclitaxel for Previously Treated Advanced Non-Small Cell Lung Cancer: JMTO LC14-01

Author

Takeuchi, Susumu, primary, Kubota, Kaoru, additional, Sugawara, Shunichi, additional, Teramukai, Satoshi, additional, Noro, Rintaro, additional, Fujikawa, Kei, additional, Hirose, Takashi, additional, Atagi, Shinji, additional, Minami, Seigo, additional, Iida, Shinichiro, additional, Kuraishi, Hiroshi, additional, Aiba, Tomoiki, additional, Minegishi, Yuji, additional, Matsumoto, Masaru, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, and Kawahara, Masaaki, additional

Published
2021
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100. EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells

Author

Miyanaga, Akihiko, primary, Matsumoto, Masaru, additional, Beck, Jessica A., additional, Horikawa, Izumi, additional, Oike, Takahiro, additional, Okayama, Hirokazu, additional, Tanaka, Hiromi, additional, Burkett, Sandra S., additional, Robles, Ana I., additional, Khan, Mohammed, additional, Lissa, Delphine, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, Mano, Hiroyuki, additional, and Harris, Curtis C., additional

Published
2020
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