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With the recent emphasis on high-throughput high performance liquid chromatography (HPLC) and ultrahigh-pressure liquid chromatography (UHPLC), chromatographers are looking for ways to improve productivity. This installment discusses the use of [...]

The Pittsburgh Conference of Analytical Chemistry and Applied Spectroscopy (Pittcon), was held March 12-18, 2011, at the World Congress Center in Atlanta, Georgia. The Pittcon 2011 technical program boasted a [...]

Ron Majors presents the second part of his yearly report on new products introduced at Pittcon 2011. This installment covers gas chromatography columns, sample preparation products, and hardware, accessories, and [...]

For well over a decade, the green chemistry movement has been JR exploring ways to reduce the risks of chemical exposure to humans and to the environment. There are many [...]

There are many advantages of dried blood spot (DBS) processing, in which a small sample of blood, in the microliter range, is spotted on a piece of filter paper and [...]

Among the first packing materials developed for high performance liquid chromatography (HPLC) in the late 1960s, the superficially porous particle (SPP) has been available for over 40 years in various [...]

HPLC 2010 was held June t9-24 in Boston, Massachusetts, for the third time in its long history. Columnist Ron Majors attended this meeting and provides first-hand coverage of some of [...]

As sample sizes get smaller and analyte concentrations lower, techniques that provide efficient extractions are needed. Liquid-phase microextraction (LPME) has become an area of increasing interest. Coupled with the use of hollow fibers that serve as a support for immobilized liquids and as a barrier between the donor and acceptor phases allows complex extractions, especially of aqueous samples, to be performed with high enrichment factors. In this installment, the subject of LPME is reviewed with emphasis on the use of hollow fibers. Applications examples will be provided., Sample preparation is a key step in chemical analysis because it is, in some cases, the slowest and most complicated step overall. Sample preparation is necessary to extract, isolate, and [...]

Sample preparation and analysis of trace compounds in difficult matrices has always been a challenge. In modern ages, the drive to expand food production to feed an ever-increasing population has [...]

For decades, reversed-phase chromatography has dominated the applications of high performance liquid chromatography (HPLC). Almost as soon as bonded reversed phases became available in the early 1970s, this mode surged [...]

Pittcon 2010, referred to in its full name as the 61st Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, returned to the massive Orange County Convention Center in Orlando, Florida, [...]

Over a decade ago, CEC was the hottest topic around. It was supposed to replace both high performance liquid chromatography (HPLC) and capillary electrophoresis (CE). Now one rarely hears about [...]

In this installment of 'Column Watch,' Ron Majors looks at the results of a recent HPLC column survey conducted by LCGC North America. He examines trends in analytical and preparative [...]

The description a chromatographic procedure in a US Pharmacopeia (USP) monograph contains necessary information that enables the procedure to be reproduced in a laboratory and typically includes system suitability requirements. [...]

HPLC 2009 was held June 28-July 2 in the former East German city of Dresden. Columnist Ron Majors attended this meeting and provides first-hand coverage of some of the technology [...]

Choices of available stationary phases for GC have been fairly constant for many years. The same basic types of columns that do analogous separations can be obtained from any of [...]

The addition of a high concentration of salt into a mixture of water and a water-miscible organic solvent results in the separation of the solvent mixture and the formation of [...]

The worldwide shortage of acetonitrile was supposed to be over in the first quarter of 2009. All indications are that, despite promises to the contrary, the shortages, allocations, and higher [...]

A decade after their introduction, stir-bar sorptive extraction (SBSE) and headspace sorptive extraction (HSSE) are widely used sample preparation techniques for trace analysis of analytes in aqueous and vapor phases. [...]

This month's installment of Column Watch features Ron Majors' yearly report on new products introduced at Pittcon. This year's event returned to Chicago, IL. Amid a worldwide financial crisis, the [...]

Recently, I had the opportunity to participate in Colacro XII, a chromatography symposium held in a Latin America country every two years. This year's meeting was held in Florianopolous, Brazil, [...]

Silica-based sorbents have dominated solid-phase extraction (SPE) for years. The introduction of polymer-based sorbents has brought many advantages. Polymers are more rugged, have a wider pH range, show excellent flow [...]

In 2001, the second glossary of common and not-so-common terms and "buzz words" for reference to HPLC columns and column technology was published (1). It is time for an update [...]

HPLC 2008 was held in Baltimore in May. Columnist Ron Majors covers the highlights of this major symposium, held in the U.S. every two years. In this month's "Column Watch" [...]

To characterize complex samples such as natural products or peptide digests, a single chromatographic dimension cannot completely separate and identify every single compound. For such cases, comprehensive two-dimensional liquid chromatography [...]

This month's installment of "Column Watch" is the second part of a two-part series in which columnist Ron Majors examines the trends and highlights in columns and consumables at Pittcon [...]

In this installment of "Column Watch," columnist Ron Majors and guest coauthor, Prof. Peter Carr of the University of Minnesota update the popular HPLC-LC glossary that covers common and not-so-common [...]

In this installment of "Column Watch," Ron Majors examines the various approaches to increasing the speed of high performance liquid chromatography (HPLC) separations. The use of small particles from 1.5 [...]

Selective sample preparation techniques are particularly attractive for the analysis of trace amounts of small molecules in complex matrices. In this month's installment, columnist Ron Majors covers the field of [...]

In this installment of "Column Watch," columnist Ron Majors examines the role of pressure in high performance liquid chromatography (HPLC) from two viewpoints: the impact of the ultrahigh pressures encountered [...]

HPLC 2007 was held in Ghent, Belgium in June. Last month, columnist Ron Majors summarized some the important column developments as well as other Symposium highlights. This month, he winds [...]

HPLC 2007 was held in Ghent, Belgium in June. The symposium had the largest numbers of submitted papers in the history of the meeting. Columnist Ron Majors covers some of [...]

In this installment of "Column Watch" columnist Ron Majors revisits expert predictions from a survey conducted in 1987. A cross section of column experts of the time were asked a [...]

The details of the 30th International Symposium on High Performance Liquid Phase Separations and Related Techniques, or HPLC 2006, are discussed. The symposium, which was held in San Francisco, California from June 17 to 22, 2006, featured over 1200 scientists from 45 countries. A total of 680 symposium papers, 160 oral sessions, 7 vendor seminars, and 520 posters in sessions with 27 themes, were presented.

In any field there are often "misconceptions" or "myths" that are perpetuated and passed on to the next generation. These myths are often driven by a lack of understanding by [...]

Methods for the extraction of solid materials are discussed. Soxhlet extraction, which is the most widely-used technique for pretreatment of solid samples, provides good analyte recovery but uses huge amounts of solvent. The processes involved in Soxhlet extraction, as well as details of other extraction methods, are also presented.

As the heart of the liquid chromatograph, HPLC column design has seen major improvements over the decades. From the early glass columns of flash chromatography to smooth wall stainless steel [...]

Liquid-liquid extraction (LLE) is among the most widely used sample preparation methods. In this month's installment of 'Sample Prep Perspectives,' Ron Majors discusses newer LLE approaches that offer significant advantages [...]

Column packing materials continue to evolve as user needs for high-throughput, high-resolution and high-sensitivity HPLC analyses drive further developments. In this introductory article to this supplement, Ron Majors covers basic [...]