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6,688 results on '"Malaguti, A"'

51. Increased glucosylsphingosine levels and Gaucher disease in GBA1-associated Parkinson's disease

Author

Marano, Massimo, Zizzo, Carmela, Malaguti, Maria Chiara, Bacchin, Ruggero, Cavallieri, Francesco, De Micco, Rosa, Spagnolo, Francesca, Bentivoglio, Anna Rita, Schirinzi, Tommaso, Bovenzi, Roberta, Ramat, Silvia, Erro, Roberto, Sorrentino, Cristiano, Sucapane, Patrizia, Pilotto, Andrea, Lupini, Alessandro, Magliozzi, Alessandro, Di Vico, Ilaria, Carecchio, Miryam, Bonato, Giulia, Cilia, Roberto, Colucci, Fabiana, Tamma, Filippo, Caputo, Elena, Mostile, Giovanni, Arabia, Gennarina, Modugno, Nicola, Zibetti, Maurizio, Ceravolo, Maria Gabriella, Tambasco, Nicola, Cossu, Giovanni, Valzania, Franco, Manganotti, Paolo, Di Lazzaro, Vincenzo, Zappia, Mario, Fabbrini, Giovanni, Tinazzi, Michele, Tessitore, Alessandro, Duro, Giovanni, and Di Fonzo, Alessio

Published
2024
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53. Diffusion-convection reaction equations with sign-changing diffusivity and bistable reaction term

Author

Berti, Diego, Corli, Andrea, and Malaguti, Luisa

Subjects
Mathematics - Analysis of PDEs, 35K65 (Primary) 35C07, 34B40, 35K57 (Secondary)
Abstract

We consider a reaction-diffusion equation with a convection term in one space variable, where the diffusion changes sign from the positive to the negative and the reaction term is bistable. We study the existence of wavefront solutions, their uniqueness and regularity. The presence of convection reveals several new features of wavefronts: according to the mutual positions of the diffusivity and reaction, profiles can occur either for a single value of the speed or for a bounded interval of such values; uniqueness (up to shifts) is lost; moreover, plateaus of arbitrary length can appear; profiles can be singular where the diffusion vanishes., Comment: 33 pages, 8 figures

Published
2021

54. Network Design with Service Requirements: Scaling-up the Size of Solvable Problems

Author

Gudapati, Naga V. C., Malaguti, Enrico, and Monaci, Michele

Subjects
Mathematics - Optimization and Control
Abstract

Network design, a cornerstone of mathematical optimization, is about defining the main characteristics of a network satisfying requirements on connectivity, capacity, and level-of-service. It finds applications in logistics and transportation, telecommunications, data sharing, energy distribution, and distributed computing. In multi-commodity network design, one is required to design a network minimizing the installation cost of its arcs and the operational cost to serve a set of point-to-point connections. The definition of this prototypical problem was recently enriched by additional constraints imposing that each origin-destination of a connection is served by a single path satisfying one or more level-of-service requirements, thus defining the Network Design with Service Requirements [Balakrishnan, Li, and Mirchandani. Operations Research, 2017]. These constraints are crucial, e.g., in telecommunications and computer networks, in order to ensure reliable and low-latency communication. In this paper we provide a new formulation for the problem, where variables are associated with paths satisfying the end-to-end service requirements. We present a fast algorithm for enumerating all the exponentially-many feasible paths and, when this is not viable, we provide a column generation scheme that is embedded into a branch-and-cut-and-price algorithm. Extensive computational experiments on a large set of instances show that our approach is able to move a step further in the solution of the Network Design with Service Requirements, compared with the current state-of-the-art.

Published
2021

56. Fumana

Author

Paolo Malaguti

Published
2024

57. The CGEM-IT readout chain

Author

Amoroso, A., Ferroli, R. Baldini, Balossino, I., Bertani, M., Bettoni, D., Bianchi, F., Bortone, A., Bugalho, R., Calcaterra, A., Cerioni, S., Chiozzi, S., Cibinetto, G., Ramusino, A. Cotta, Cossio, F., Rolo, M. Da Rocha, De Mori, F., Destefanis, M., Di Francesco, A., Evangelisti, F., Farinelli, R., Fava, L., Felici, G., Garbolino, S., Garzia, I., Gatta, M., Giraudo, G., Gramigna, S., Greco, M., Lavezzi, L., Maggiora, M., Malaguti, R., Mangoni, A., Marcello, S., Marciniewski, P., Melchiorri, M., Mezzadri, G., Mignone, M., Morgante, S., Pace, E., Pacetti, S., Patteri, P., Rivetti, A., Scodeggio, M., Sosio, S., Spataro, S., Varela, J., and Wheadon, R.

Subjects
Physics - Instrumentation and Detectors
Abstract

An innovative Cylindrical Gas Electron Multiplier (CGEM) detector is under construction for the upgrade of the inner tracker of the BESIII experiment. A novel system has been worked out for the readout of the CGEM detector, including a new ASIC, dubbed TIGER -Torino Integrated GEM Electronics for Readout, designed for the amplification and digitization of the CGEM output signals. The data output by TIGER are collected and processed by a first FPGA-based module, GEM Read Out Card, in charge of configuration and control of the front-end ASICs. A second FPGA-based module, named GEM Data Concentrator, builds the trigger selected event packets containing the data and stores them via the main BESIII data acquisition system. The design of the electronics chain, including the power and signal distribution, will be presented together with its performance.

Published
2021
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58. Ariel: Enabling planetary science across light-years

Author

Tinetti, Giovanna, Eccleston, Paul, Haswell, Carole, Lagage, Pierre-Olivier, Leconte, Jérémy, Lüftinger, Theresa, Micela, Giusi, Min, Michel, Pilbratt, Göran, Puig, Ludovic, Swain, Mark, Testi, Leonardo, Turrini, Diego, Vandenbussche, Bart, Osorio, Maria Rosa Zapatero, Aret, Anna, Beaulieu, Jean-Philippe, Buchhave, Lars, Ferus, Martin, Griffin, Matt, Guedel, Manuel, Hartogh, Paul, Machado, Pedro, Malaguti, Giuseppe, Pallé, Enric, Rataj, Mirek, Ray, Tom, Ribas, Ignasi, Szabó, Robert, Tan, Jonathan, Werner, Stephanie, Ratti, Francesco, Scharmberg, Carsten, Salvignol, Jean-Christophe, Boudin, Nathalie, Halain, Jean-Philippe, Haag, Martin, Crouzet, Pierre-Elie, Kohley, Ralf, Symonds, Kate, Renk, Florian, Caldwell, Andrew, Abreu, Manuel, Alonso, Gustavo, Amiaux, Jerome, Berthé, Michel, Bishop, Georgia, Bowles, Neil, Carmona, Manuel, Coffey, Deirdre, Colomé, Josep, Crook, Martin, Désjonqueres, Lucile, Díaz, José J., Drummond, Rachel, Focardi, Mauro, Gómez, Jose M., Holmes, Warren, Krijger, Matthijs, Kovacs, Zsolt, Hunt, Tom, Machado, Richardo, Morgante, Gianluca, Ollivier, Marc, Ottensamer, Roland, Pace, Emanuele, Pagano, Teresa, Pascale, Enzo, Pearson, Chris, Pedersen, Søren Møller, Pniel, Moshe, Roose, Stéphane, Savini, Giorgio, Stamper, Richard, Szirovicza, Peter, Szoke, Janos, Tosh, Ian, Vilardell, Francesc, Barstow, Joanna, Borsato, Luca, Casewell, Sarah, Changeat, Quentin, Charnay, Benjamin, Civiš, Svatopluk, Foresto, Vincent Coudé du, Coustenis, Athena, Cowan, Nicolas, Danielski, Camilla, Demangeon, Olivier, Drossart, Pierre, Edwards, Billy N., Gilli, Gabriella, Encrenaz, Therese, Kiss, Csaba, Kokori, Anastasia, Ikoma, Masahiro, Morales, Juan Carlos, Mendonça, João, Moneti, Andrea, Mugnai, Lorenzo, Muñoz, Antonio García, Helled, Ravit, Kama, Mihkel, Miguel, Yamila, Nikolaou, Nikos, Pagano, Isabella, Panic, Olja, Rengel, Miriam, Rickman, Hans, Rocchetto, Marco, Sarkar, Subhajit, Selsis, Franck, Tennyson, Jonathan, Tsiaras, Angelos, Venot, Olivia, Vida, Krisztián, Waldmann, Ingo P., Yurchenko, Sergey, Szabó, Gyula, Zellem, Rob, Al-Refaie, Ahmed, Alvarez, Javier Perez, Anisman, Lara, Arhancet, Axel, Ateca, Jaume, Baeyens, Robin, Barnes, John R., Bell, Taylor, Benatti, Serena, Biazzo, Katia, Błęcka, Maria, Bonomo, Aldo Stefano, Bosch, José, Bossini, Diego, Bourgalais, Jeremy, Brienza, Daniele, Brucalassi, Anna, Bruno, Giovanni, Caines, Hamish, Calcutt, Simon, Campante, Tiago, Canestrari, Rodolfo, Cann, Nick, Casali, Giada, Casas, Albert, Cassone, Giuseppe, Cara, Christophe, Carone, Ludmila, Carrasco, Nathalie, Chioetto, Paolo, Cortecchia, Fausto, Czupalla, Markus, Chubb, Katy L., Ciaravella, Angela, Claret, Antonio, Claudi, Riccardo, Codella, Claudio, Comas, Maya Garcia, Cracchiolo, Gianluca, Cubillos, Patricio, Da Peppo, Vania, Decin, Leen, Dejabrun, Clemence, Delgado-Mena, Elisa, Di Giorgio, Anna, Diolaiti, Emiliano, Dorn, Caroline, Doublier, Vanessa, Doumayrou, Eric, Dransfield, Georgina, Dumaye, Luc, Dunford, Emma, Escobar, Antonio Jimenez, Van Eylen, Vincent, Farina, Maria, Fedele, Davide, Fernández, Alejandro, Fleury, Benjamin, Fonte, Sergio, Fontignie, Jean, Fossati, Luca, Funke, Bernd, Galy, Camille, Garai, Zoltán, García, Andrés, García-Rigo, Alberto, Garufi, Antonio, Sacco, Giuseppe Germano, Giacobbe, Paolo, Gómez, Alejandro, Gonzalez, Arturo, Gonzalez-Galindo, Francisco, Grassi, Davide, Griffith, Caitlin, Guarcello, Mario Giuseppe, Goujon, Audrey, Gressier, Amélie, Grzegorczyk, Aleksandra, Guillot, Tristan, Guilluy, Gloria, Hargrave, Peter, Hellin, Marie-Laure, Herrero, Enrique, Hills, Matt, Horeau, Benoit, Ito, Yuichi, Jessen, Niels Christian, Kabath, Petr, Kálmán, Szilárd, Kawashima, Yui, Kimura, Tadahiro, Knížek, Antonín, Kreidberg, Laura, Kruid, Ronald, Kruijssen, Diederik J. M., Kubelík, Petr, Lara, Luisa, Lebonnois, Sebastien, Lee, David, Lefevre, Maxence, Lichtenberg, Tim, Locci, Daniele, Lombini, Matteo, Lopez, Alejandro Sanchez, Lorenzani, Andrea, MacDonald, Ryan, Magrini, Laura, Maldonado, Jesus, Marcq, Emmanuel, Migliorini, Alessandra, Modirrousta-Galian, Darius, Molaverdikhani, Karan, Molinari, Sergio, Mollière, Paul, Moreau, Vincent, Morello, Giuseppe, Morinaud, Gilles, Morvan, Mario, Moses, Julianne I., Mouzali, Salima, Nakhjiri, Nariman, Naponiello, Luca, Narita, Norio, Nascimbeni, Valerio, Nikolaou, Athanasia, Noce, Vladimiro, Oliva, Fabrizio, Palladino, Pietro, Papageorgiou, Andreas, Parmentier, Vivien, Peres, Giovanni, Pérez, Javier, Perez-Hoyos, Santiago, Perger, Manuel, Pestellini, Cesare Cecchi, Petralia, Antonino, Philippon, Anne, Piccialli, Arianna, Pignatari, Marco, Piotto, Giampaolo, Podio, Linda, Polenta, Gianluca, Preti, Giampaolo, Pribulla, Theodor, Puertas, Manuel Lopez, Rainer, Monica, Reess, Jean-Michel, Rimmer, Paul, Robert, Séverine, Rosich, Albert, Rossi, Loic, Rust, Duncan, Saleh, Ayman, Sanna, Nicoletta, Schisano, Eugenio, Schreiber, Laura, Schwartz, Victor, Scippa, Antonio, Seli, Bálint, Shibata, Sho, Simpson, Caroline, Shorttle, Oliver, Skaf, N., Skup, Konrad, Sobiecki, Mateusz, Sousa, Sergio, Sozzetti, Alessandro, Šponer, Judit, Steiger, Lukas, Tanga, Paolo, Tackley, Paul, Taylor, Jake, Tecza, Matthias, Terenzi, Luca, Tremblin, Pascal, Tozzi, Andrea, Triaud, Amaury, Trompet, Loïc, Tsai, Shang-Min, Tsantaki, Maria, Valencia, Diana, Vandaele, Ann Carine, Van der Swaelmen, Mathieu, Vardan, Adibekyan, Vasisht, Gautam, Vazan, Allona, Del Vecchio, Ciro, Waltham, Dave, Wawer, Piotr, Widemann, Thomas, Wolkenberg, Paulina, Yip, Gordon Hou, Yung, Yuk, Zilinskas, Mantas, Zingales, Tiziano, and Zuppella, Paola

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

Ariel, the Atmospheric Remote-sensing Infrared Exoplanet Large-survey, was adopted as the fourth medium-class mission in ESA's Cosmic Vision programme to be launched in 2029. During its 4-year mission, Ariel will study what exoplanets are made of, how they formed and how they evolve, by surveying a diverse sample of about 1000 extrasolar planets, simultaneously in visible and infrared wavelengths. It is the first mission dedicated to measuring the chemical composition and thermal structures of hundreds of transiting exoplanets, enabling planetary science far beyond the boundaries of the Solar System. The payload consists of an off-axis Cassegrain telescope (primary mirror 1100 mm x 730 mm ellipse) and two separate instruments (FGS and AIRS) covering simultaneously 0.5-7.8 micron spectral range. The satellite is best placed into an L2 orbit to maximise the thermal stability and the field of regard. The payload module is passively cooled via a series of V-Groove radiators; the detectors for the AIRS are the only items that require active cooling via an active Ne JT cooler. The Ariel payload is developed by a consortium of more than 50 institutes from 16 ESA countries, which include the UK, France, Italy, Belgium, Poland, Spain, Austria, Denmark, Ireland, Portugal, Czech Republic, Hungary, the Netherlands, Sweden, Norway, Estonia, and a NASA contribution., Comment: Ariel Definition Study Report, 147 pages. Reviewed by ESA Science Advisory Structure in November 2020. Original document available at: https://www.cosmos.esa.int/documents/1783156/3267291/Ariel_RedBook_Nov2020.pdf/

Published
2021

59. Machine Learning Insights into the Last 400 Years of Etna Lateral Eruptions from Historical Volcanological Data

Author

Arianna Beatrice Malaguti, Claudia Corradino, Alessandro La Spina, Stefano Branca, and Ciro Del Negro

Subjects
machine learning, artificial intelligence, Etna volcano, effusive eruptions, volcanic hazard, K-means clustering, Geology, QE1-996.5
Abstract

Volcanic hazard assessment is generally based on past eruptive behavior, assuming that previous activity is representative of future activity. Hazard assessment can be supported by Artificial Intelligence (AI) techniques, such as machine learning, which are used for data exploration to identify features of interest in the data. Here, we applied a machine learning technique to automate the analysis of these datasets, handling intricate patterns that are not easily captured by explicit commands. Using the k-means clustering algorithm, we classified effusive eruptions of Mount Etna over the past 400 years based on key parameters, including lava volume, Mean Output Rate (MOR), and eruption duration. Our analysis identified six distinct eruption clusters, each characterized by unique eruption dynamics. Furthermore, spatial analysis revealed significant sectoral variations in eruption activity across Etna’s flanks. These findings, derived through unsupervised learning, offer new insights into Etna’s eruptive behavior and contribute to the development of hazard maps that are essential for long-term spatial planning and risk mitigation.

Published
2024
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60. Validity of the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F) in individuals with Chronic Obstructive Pulmonary Disease in Brazil

Author

Gabriela Pereira Correa, Cristino Carneiro Oliveira, Gláucia Cópio Vieira, Leandro Ferracini Cabral, Carla Malaguti, and Anderson José

Subjects
Chronic Obstructive Pulmonary Disease, Fatigue, Exercise Tolerance, Therapeutics. Pharmacology, RM1-950
Abstract

ABSTRACT Fatigue is one of the most prevalent symptoms in individuals with Chronic Obstructive Pulmonary Disease (COPD), but it is poorly evaluated. The Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F) is one of the main instruments used to measure fatigue. However, this instrument has not yet been validated for the Brazilian population with COPD. This study aimed to investigate the validity of the FACIT-F fatigue scale in individuals with COPD. In a cross-sectional study, the impact of symptoms (COPD Assessment Test - CAT), dyspnea (modified Medical Research Council - MRC scale), functional capacity (six-minute step test - 6MST), exertional fatigue (Borg modified scale at the end of 6MST), and the FACIT-F scale to assess multidimensional fatigue were evaluated. Concurrent validity was assessed by associating the FACIT-F with the CAT, and convergent validity by associating it with the number of steps, perceived exertional fatigue, and dyspnea. Discriminant validity was assessed by comparing fatigue with the dyspnea severity strata. In total, 92 participants were studied (69.9±8.8 years, FEV1: 48.4% of predicted). The FACIT-F presented an average of 30.1±10.9 points, strong concurrent validity with the CAT (r=-0.80), strong convergent validity with dyspnea (r=−0.66), and low with exercise capacity (r=0.40) and fatigue on exertion (r=-0.44). FACIT-F was effective in discriminating groups with different intensities of dyspnea. Conclusion: The FACIT-F is a valid tool for assessing fatigue in the Brazilian population with COPD.

Published
2024
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61. BAMBOO LANTERN FESTIVAL - A SOCIAL DESIGN EXPERIENCE INTEGRATING THE UNIVERSITY AND THE LOCAL COMMUNITY

Author

Silvia Sasaoka, Marco Antonio dos Reis Pereira, and Cyntia Santos Malaguti de Sousa

Subjects
social design, bamboo, education for sustainability, Architecture, NA1-9428, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Environmental degradation and global social inequality require an education focused on transforming values and practices in today's world. Bamboo, both as a plant and a material, has mitigated the impacts of climate change. Combined with design within a bamboo productive chain, it also enhances the possibility of a pedagogical dimension for design students and the participation of local communities. This study aims to examine how social design can collaborate in education for sustainability, involving the researcher’s participant observation and co-creation, which resulted in the Take Akari Bamboo Lantern Workshop, held at the Unesp Campus in Bauru/SP. Results show that social design combined with bamboo helps in motivating people to internalize and carry out new practices due to the collaborative and collective ways of working collectively based on which it was held, and is capable of transforming scenarios and changing beliefs and values.

Published
2024
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62. DESIGN SCENARIOS AND ECOTOPIAS. NOTES FOR THE DEVELOPMENT OF A SOCIO-ENVIRONMENTAL DESIGN LABORATORY

Author

Carlo Franzato, Natali Abreu Garcia, Maria Eloisa de Jesus Conceição, Lia Astudillo Poblete, Daniel Malaguti Campos, Clara Peixoto Acioli, Adriana Basto Aquim, and Alfredo Jefferson de Oliveira

Subjects
Crisis, Design for sustainability, Ecology, Scenarios, Ecotopias, Architecture, NA1-9428, Engineering (General). Civil engineering (General), TA1-2040
Abstract

This paper presents the conceptual underpinnings organized by a group of designers and design researchers for the creation of the Ecotopias Socioenvironmental Design Laboratory at PUC-Rio University. It begins by discussing the anthropogenic crisis, which the planet is currently facing, and the consequent design crisis. It also presents the field of design for sustainability, its transversality and eco-logic possibilities. It situates the process of constructing scenarios in this field as a methodological option for opening the imaginative and anticipatory potential of art and design to confront the planetary environmental crises and regenerate ecologies of the mind, social relations, and the environment. It describes the methodological steps of the scenario-building process derived from the project Sustainable Everyday, and, finally, it distinguishes the concepts of utopia and ecotopia.

Published
2024
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63. Wavefronts for degenerate diffusion-convection reaction equations with sign-changing diffusivity

Author

Berti, Diego, Corli, Andrea, and Malaguti, Luisa

Subjects
Mathematics - Analysis of PDEs, 35K65 (Primary) 35C07, 34B40, 35K57 (Secondary)
Abstract

We consider in this paper a diffusion-convection reaction equation in one space dimension. The main assumptions are about the reaction term, which is monostable, and the diffusivity, which changes sign once or twice; then, we deal with a forward-backward parabolic equation. Our main results concern the existence of globally defined traveling waves, which connect two equilibria and cross both regions where the diffusivity is positive and regions where it is negative. We also investigate the monotony of the profiles and show the appearance of sharp behaviours at the points where the diffusivity degenerates. In particular, if such points are interior points, then the sharp behaviours are new and unusual., Comment: 25 pages, 9 figures. Changes in the exposition; final version

Published
2020

64. Uniqueness and nonuniqueness of fronts for degenerate diffusion-convection reaction equations

Author

Berti, Diego, Corli, Andrea, and Malaguti, Luisa

Subjects
Mathematics - Analysis of PDEs, 35K65, 35C07, 34B40, 35K57
Abstract

We consider a scalar parabolic equation in one spatial dimension. The equation is constituted by a convective term, a reaction term with one or two equilibria, and a positive diffusivity which can however vanish. We prove the existence and several properties of traveling-wave solutions to such an equation. In particular, we provide a sharp estimate for the minimal speed of the profiles and improve previous results about the regularity of wavefronts. Moreover, we show the existence of an infinite number of semi-wavefronts with the same speed., Comment: 35 pages, 10 figures; submitted version. Revision with exposition changes, typos fixed and assumption (6.3) added to Propositions 6.1 and 8.2

Published
2020

65. PARSIFAL: a toolkit for triple-GEM parametrized simulation

Author

Amoroso, A., Ferroli, R. Baldini, Balossino, I., Bertani, M., Bettoni, D., Bianchi, F., Bortone, A., Calcaterra, A., Cerioni, S., Cheng, W., Cibinetto, G., Ramusino, A. Cotta, Cossio, F., Rolo, M. Da Rocha, De Mori, F., Destefanis, M., Dong, J., Evangelisti, F., Farinelli, R., Fava, L., Felici, G., Garzia, I., Gatta, M., Giraudo, G., Gramigna, S., Greco, M., Lavezzi, L., Maggiora, M., Malaguti, R., Mangoni, A., Marcello, S., Melchiorri, M., Mezzadri, G., Pace, E., Pacetti, S., Patteri, P., Pellegrino, J., Rivetti, A., Scodeggio, M., Sosio, S., and Spataro, S.

Subjects
Physics - Instrumentation and Detectors
Abstract

PARSIFAL (PARametrized SImulation by Farinelli And Lavezzi) is a fast and reliable software tool that reproduces the complete response of a triple-GEM detector to the passage of a charged particle, taking into account the main physical effects. Starting from the detector configuration and the particle information, PARSIFAL reproduces ionization, spatial and temporal diffusion, effect of magnetic field, if present, and GEM amplification to provide the dependable triple-GEM detector response. In the design and optimization stages of this kind of detectors, simulations play an important role. Accurate and robust software programs, such as GARFIELD++, can simulate the transport of electrons and ions in a gas medium and their interaction with the electric field, but they are CPU-time consuming. The necessity to reduce the processing time while maintaining the precision of a full simulation is the main driver of this work. For a given set of geometrical and electrical settings, GARFIELD++ is run once-and-for-all to provide the input parameters for PARSIFAL. Once PARSIFAL is initialized and run, it produces the detector output, including the signal induction and the output of the electronics. The results of the analysis of the simulated data obtained with PARSIFAL are compared with the results of the experimental data collected during a testbeam: some tuning factors are applied to the simulation to improve the agreement. This paper describes the structure of the code and the methodology used to match the output to the experimental data., Comment: submitted to Computer Physics Communications, CPiC

Published
2020

66. Time performance of a triple-GEM detector at high rate

Author

Amoroso, A., Ferroli, R. Baldini, Balossino, I., Bertani, M., Bettoni, D., Bortone, A., Calcaterra, A., Cerioni, S., Cheng, W., Cibinetto, G., Ramusino, A. Cotta, Cossio, F., Rolo, M. Da Rocha, De Mori, F., Denig, A., Destefanis, M., Dong, J., Evangelisti, F., Farinelli, R., Fava, L., Felici, G., Garillon, B., Garzia, I., Gatta, M., Giraudo, G., Gramigna, S., Greco, M., Gülker, P., Guo, Y. P., Lauth, W., Lavezzi, L., Maggiora, M., Malaguti, R., Mangoni, A., Marcello, S., Melchiorri, M., Mezzadri, G., Pace, E., Pacetti, S., Patteri, P., Pellegrino, J., Redmer, C. F., Ripka, M., Rivetti, A., Rosner, C., Scodeggio, M., Sosio, S., and Spataro, S.

Subjects
Physics - Instrumentation and Detectors
Abstract

Gaseous detectors are used in high energy physics as trackers or, more generally, as devices for the measurement of the particle position. For this reason, they must provide high spatial resolution and they have to be able to operate in regions of intense radiation, i.e. around the interaction point of collider machines. Among these, Micro Pattern Gaseous Detectors (MPGD) are the latest frontier and allow to overcome many limitations of the pre-existing detectors, such as the radiation tolerance and the rate capability. The gas Electron Multiplier (GEM) is a MPGD that exploits an intense electric field in a reduced amplification region in order to prevent discharges. Several amplification stages, like in a triple-GEM, allow to increase the detector gain and to reduce the discharge probability. Reconstruction techniques such as charge centroid (CC) and micro-Time Projection Chamber ($\upmu$TPC) are used to perform the position measurement. From literature triple-GEMs show a stable behaviour up to $10^8\,$Hz/cm$^2$. A testbeam with four planar triple-GEMs has been performed at the Mainz Microtron (MAMI) facility and their performance was evaluated in different beam conditions. In this article a focus on the time performance for the $\upmu$TPC clusterization is given and a new measurement of the triple-GEM limits at high rate will be presented.

Published
2020
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68. Feasibility, Applicability and Incentives in Using Sustainable Materials: Comparative Between Brazil and Portugal

Author

de Moraes, Clauciana Schmidt Bueno, de Souza Lima, Stephani Cristine, Bonaretto, Cínthia Mara Vital, Mártires, Giulia Malaguti Braghini Marcolini, de Almeida, Natasha Nême Gonçalves, Pinheiro, Manuel Duarte, Amado, Miguel Pires, Rocha, Rodrigo Prieto, Gualter, Leonardo Prudente Torres, Howlett, Robert J., Series Editor, Littlewood, John, Series Editor, Jain, Lakhmi C., Series Editor, Semião, Jorge Filipe Leal Costa, editor, Sousa, Nelson Manuel Santos, editor, da Cruz, Rui Mariano Sousa, editor, and Prates, Gonçalo Nuno Delgado, editor

Published
2023
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70. Comparative Analysis and Applicability of Norms and Legislation Related to Law 12.305/10-Politica Nacional de Residuos Solidos (PNRS)/ Analise Comparativa e Aplicabilidade das Normas e Legislacoes Correlatas a Lei 12.305/10-Politica Nacional de Residuos Solidos (PNRS)

Author

de Moraes, Clauciana Schmidt Bueno, Maia, Juliana Victoria Ferreira, Pinto, Willian Leandro Henrique, Juliao, Danielle Paes, Bonaretto, Cinthia Mara Vital, Martires, Giulia Malaguti Braghini Marcolini, and Camolezi, Juliane Zaccarias

Published
2023
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73. PARSIFAL: A toolkit for triple-GEM parametrized simulation

Author

Amoroso, A., Baldini Ferroli, R., Balossino, I., Bertani, M., Bettoni, D., Bianchi, F., Bortone, A., Calcaterra, A., Cerioni, S., Cheng, W., Cibinetto, G., Cotta Ramusino, A., Cotto, G., Cossio, F., Da Rocha Rolo, M., De Mori, F., Destefanis, M., Dong, J., Evangelisti, F., Farinelli, R., Fava, L., Felici, G., Garzia, I., Gatta, M., Giraudo, G., Gramigna, S., Greco, M., Lavezzi, L., Maggiora, M., Malaguti, R., Mangoni, A., Marcello, S., Melchiorri, M., Mezzadri, G., Pace, E., Pacetti, S., Patteri, P., Pellegrino, J., Rivetti, A., Scodeggio, M., Sosio, S., and Spataro, S.

Published
2024
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74. Antioxidant, antitumoral, antimetastatic effect and inhibition of collagenase enzyme activity of Eleutherine bulbosa (Dayak onion) extract: In vitro, in vivo and in silico approaches

Author

Silva, Regildo Márcio Gonçalves da, Alves, Caio Pismel, Barbosa, Fernando Cesar, Santos, Hugo Henrique, Adão, Kaue Mendonça, Granero, Filipe Oliveira, Figueiredo, Célia Cristina Malaguti, Figueiredo, Carlos Rogério, Nicolau-Junior, Nilson, and Silva, Luciana Pereira

Published
2024
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77. Standardizing practices and flux predictions in membrane science via simplified equations and membrane characterization

Author

Alberto Tiraferri, Marco Malaguti, Madina Mohamed, Mattia Giagnorio, and Fynn Jerome Aschmoneit

Subjects
Water supply for domestic and industrial purposes, TD201-500
Abstract

Abstract The development of membranes and membrane-based separation processes should be accompanied by a standardization of the protocols applied for membrane characterization and for data analysis. Here, streamlined equations for the estimation of the water flux and of the observed salt permeability coefficient in pressure-driven processes deploying dense membranes are presented. Also, a protocol for the experimental characterization of the transport properties of dense membranes is presented and the results are validated against the proposed equations. The proposed water flux equation is algebraic, whereas the ordinary equation needs to be solved iteratively. Moreover, in contrast to the traditional expression for the solute transport coefficient, which requires estimation of the concentration polarization, the respective equation proposed in this study only requires bulk parameters. Dimensionless variables for water flux, driving pressure, and mass transfer are introduced, and a filtration efficiency is defined, a useful parameter in terms of process design.

Published
2023
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78. Integrating health psychology into hepatitis C treatment : a self-efficAcy intervention to reDuce injecting risk behAviour and hePatitis C reinfecTion rates (ADAPT)

Author

Malaguti, Amy, Sani, Fabio, and Dillon, John

Subjects
616.3
Abstract

This thesis is divided into two main sections. The introductory section comprises studies one and two, while the pilot RCT section comprises studies three and four. The initial two studies were carried out to inform the latter two. Injecting behaviour in people who inject drugs (PWID) is a significant risk factor for hepatitis C virus (HCV) infection. Self-efficacy has been shown to be associated with injecting risk behaviour. The risk of HCV re-infection in people who inject drugs (PWID) treated for HCV remains high when sharing of injecting equipment continues post-treatment. The first study aimed to assess the effectiveness of forming implementation intentions to reduce substance use. Implementation intentions are self-regulatory processes which help achieve health-related behaviour change. A systematic search of published literature was conducted to gather evidence on the effectiveness of the use of implementation intentions for substance use behaviours from existing studies. The findings of studies selected from this search were collated to carry out a meta-analysis in order to produce evidence for the effectiveness of implementation intentions within substance use behaviours, informing study 3. Significant effects were found of implementation intentions on alcohol use and tobacco smoking. A small non-statistically significant result was reported for self-efficacy. No studies were found in the systematic search on the use of implementation intentions for the reduction of illicit drug use. The second study aimed to investigate possible injecting behaviour changes associated with clinical treatment of HCV. The chapter reports the results from a data analysis exercise completed in January 2018 on participants of Eradicate-C, a clinical trial of HCV treatment in PWID. A significant reduction in weekly injecting frequency was reported by participants on treatment (n=84). The third study, ADAPT, represents the main study of this thesis. ADAPT is a pilot randomised controlled trial testing the use of implementation intentions with people who inject drugs on treatment for hepatitis C to increase self-efficacy and reduce sharing of injecting equipment. It involved four visits over the course of participants' HCV treatment. The intervention was carried out during the second visit. Psychosocial factors measured during visit 1 of ADAPT (n=50) were explored as predictors of the primary outcome, injecting risk behaviour. A regression analysis was performed with bootstrapping to test a predicting model of injecting risk behaviour as explained by injecting frequency, identification with family and identification with drug network. Identification with drug network was the only significant predictor of injecting risk behaviour. Correlation analyses showed strong correlations between self-efficacy, injecting risk behaviour, injecting frequency and group identification with drug network. No significant differences were found between control and intervention groups on self-efficacy and injecting risk behaviour (n=32). The fourth study is a sub-study of ADAPT. This study was a qualitative investigation of the lived experience of PWID who are infected with HCV. Thematic analysis was used to analyse the findings of the study. It was run concurrently with ADAPT. Three overarching themes were identified in the interview transcripts: 1. "Changing illness perception"; 2. "Shifting agency"; 3. "Treatment adherence". The last chapter of the thesis aims to integrate the findings of study 3 and 4 into one final discussion. It also aims to provide a narrative reflection on the lessons learnt whilst planning and conducting the research with a hard-to-reach population, concluding with implications of the findings, the limitation of the studies and the suggestions for future research.

Published
2021

79. Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation

Author

Maria Cristina Barbalace, Michela Freschi, Irene Rinaldi, Lorenzo Zallocco, Marco Malaguti, Clementina Manera, Gabriella Ortore, Mariachiara Zuccarini, Maurizio Ronci, Doretta Cuffaro, Marco Macchia, Silvana Hrelia, Laura Giusti, Maria Digiacomo, and Cristina Angeloni

Subjects
oleocanthal, oleocanthalic acid, neuroinflammation, BV-2 microglial cells, lipopolysaccharide, TLR4, Therapeutics. Pharmacology, RM1-950
Abstract

Neuroinflammation is a critical aspect of various neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. This study investigates the anti-neuroinflammatory properties of oleocanthal and its oxidation product, oleocanthalic acid, using the BV-2 cell line activated with lipopolysaccharide. Our findings revealed that oleocanthal significantly inhibited the production of pro-inflammatory cytokines and reduced the expression of inflammatory genes, counteracted oxidative stress induced by lipopolysaccharide, and increased cell phagocytic activity. Conversely, oleocanthalic acid was not able to counteract lipopolysaccharide-induced activation. The docking analysis revealed a plausible interaction of oleocanthal, with both CD14 and MD-2 leading to a potential interference with TLR4 signaling. Since our data show that oleocanthal only partially reduces the lipopolysaccharide-induced activation of NF-kB, its action as a TLR4 antagonist alone cannot explain its remarkable effect against neuroinflammation. Proteomic analysis revealed that oleocanthal counteracts the LPS modulation of 31 proteins, including significant targets such as gelsolin, clathrin, ACOD1, and four different isoforms of 14-3-3 protein, indicating new potential molecular targets of the compound. In conclusion, oleocanthal, but not oleocanthalic acid, mitigates neuroinflammation through multiple mechanisms, highlighting a pleiotropic action that is particularly important in the context of neurodegeneration.

Published
2024
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81. Exploring the impact of the environment on physical activity in patients with chronic obstructive pulmonary disease (EPCOT)-A comparative analysis between suggested and free walking: Protocol study.

Author

Larissa Guimarães Paiva, Túlio Medina Dutra de Oliveira, Nara Batista de Souza, Klaus Chaves Alberto, Daniela Pereira Almeida, Cristino Carneiro Oliveira, Anderson José, and Carla Malaguti

Subjects
Medicine, Science
Abstract

BackgroundIndividuals with chronic obstructive pulmonary disease (COPD) exhibit reduced levels of physical activity, which are associated with poorer outcomes. The number of clinical trials aiming to promote behavioral changes to increase physical activity in this population has grown; therefore, these trials have yet to produce satisfactory results. An ecological model encompassing individual, social, environmental, and political factors represent a potentially more effective approach to promoting physical activity. While favorable urban environments can positively impact physical activity, specifically tailored environmental interventions for individuals with COPD could enhance their engagement in physical activity. Therefore, the aim of this randomized controlled trial (RCT) study was to analyze the effects of walking in a suggested environment and free walking on physical activity levels in individuals with COPD.MethodsThe environment on physical activity for chronic obstructive disease (EPCOT) is a randomized controlled clinical trial protocol approved by our institution's Ethics Committee and registered with The Brazilian Registry of Clinical Trials (ReBEC) (https://ensaiosclinicos.gov.br, number RBR-4tfwdhp). This protocol will involve 38 volunteers diagnosed with COPD recruited from the pulmonary physiotherapy and rehabilitation service. The volunteers were randomly divided into two walking groups: an experimental group (ERG) with guidance for walking in a suggested environment and an active control group (ACG) instructed to choose their own routes. The intervention consisted of eight consecutive weeks, with progressive walks carried out 3 to 5 times weekly. The primary outcome will be assessing participants' physical activity levels. Secondary outcomes will include exercise capacity, quality of life, dyspnea levels, motivation, anxiety, depression, and perceptions of the environment. All assessments will occur before and after the intervention period, aiming to fill a literature gap by investigating the impact of urban environments on COPD-related physical activity. The results may shed light on the importance of environmental factors in promoting physical activity among individuals with COPD, helping to develop more effective interventions.

Published
2024
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83. Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA?

Author

Veraldi, Noemi, Quadri, Isabelle Dentand, van de Looij, Yohan, Modernell, Laura Malaguti, Sinquin, Corinne, Zykwinska, Agata, Tournier, Benjamin B., Dalonneau, Fabien, Li, Honglian, Li, Jin-Ping, Millet, Philippe, Vives, Romain, Colliec-Jouault, Sylvia, de Agostini, Ariane, Sanches, Eduardo Farias, and Sizonenko, Stéphane V.

Published
2023
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86. In Search of Dense Subgraphs: How Good is Greedy Peeling?

Author

Gudapati, Naga V. C., Malaguti, Enrico, and Monaci, Michele

Subjects
Computer Science - Data Structures and Algorithms
Abstract

The problem of finding the densest subgraph in a given graph has several applications in graph mining, particularly in areas like social network analysis, protein and gene analyses etc. Depending on the application, finding dense subgraphs can be used to determine regions of high importance, similar characteristics or enhanced interaction. The densest subgraph extraction problem is a fundamentally a non-linear optimization problem. Nevertheless, it can be solved in polynomial time by an exact algorithm based on the iterative solution of a series of maximum flow sub-problems. Despite its polynomial time complexity, the computing time required by the exact algorithms on very large graphs could be prohibitive. Thus, to approach graphs with millions of vertices and edges, one has to resort to heuristic algorithms. We provide an efficient implementation of a greedy heuristic from the literature that is extremely fast and has some nice theoretical properties. We also introduce a new heurisitic algorithm that is built on top of the greedy and the exact methods. An extensive computational study is presented to evaluate the performance of various solution methods on a benchmark composed of 86 instances taken from the literature. This analysis shows that the proposed heuristic algorithm proved very effective on a large number of test instances, often providing either the optimal solution or near-optimal solution within short computing times., Comment: 15 pages

Published
2019

87. Triple GEM performance in magnetic field

Author

Alexeev, M., Amoroso, A., Bagnasco, S., Ferroli, R. Baldini, Balossino, I., Bencivenni, G., Bertani, M., Bettoni, D., Bianchi, F., Bortone, A., Calcaterra, A., Capodiferro, M., Carassiti, V., Cerioni, S., Chai, J., Cheng, W., Chiozzi, S., Cibinetto, G., Ramusino, A. Cotta, Cotto, G., Cossio, F., Rolo, M. Da Rocha, De Mori, F., Destefanis, M., Domenici, D., Dong, J., Evangelisti, F., Farinelli, R., Fava, L., Felici, G., Fioravanti, E., Gaido, L., Garzia, I., Gatta, M., Giraudo, G., Greco, M., Lavezzi, L., Leng, C., Li, H., Li, P., Lusso, S., Maggiora, M., Malaguti, R., Mangoni, A., Marcello, S., Melchiorri, M., Mezzadri, G., Morello, G., Mignone, M., Pace, E., Pacetti, S., Papalino, G., Passalacqua, B., Patteri, P., Pelosi, A., Lener, M. Poli, Rivetti, A., Savrié, M., Scodeggio, M., Sosio, S., Spataro, S., Tskhadadze, E., Verma, S., Yan, L., Wang, B., Weadon, R. J., and Zhang, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Performance of triple GEM prototypes in strong magnetic field has been evaluated bymeans of a muon beam at the H4 line of the SPS test area at CERN. Data have been reconstructedand analyzed offline with two reconstruction methods: the charge centroid and the micro-Time-Projection-Chamber exploiting the charge and the time measurement respectively. A combinationof the two reconstruction methods is capable to guarantee a spatial resolution better than 150{\mu}min magnetic field up to a 1 T.

Published
2019
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88. Real-time Tracking-by-Detection of Human Motion in RGB-D Camera Networks

Author

Malaguti, Alessandro, Carraro, Marco, Guidolin, Mattia, Tagliapietra, Luca, Menegatti, Emanuele, and Ghidoni, Stefano

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

This paper presents a novel real-time tracking system capable of improving body pose estimation algorithms in distributed camera networks. The first stage of our approach introduces a linear Kalman filter operating at the body joints level, used to fuse single-view body poses coming from different detection nodes of the network and to ensure temporal consistency between them. The second stage, instead, refines the Kalman filter estimates by fitting a hierarchical model of the human body having constrained link sizes in order to ensure the physical consistency of the tracking. The effectiveness of the proposed approach is demonstrated through a broad experimental validation, performed on a set of sequences whose ground truth references are generated by a commercial marker-based motion capture system. The obtained results show how the proposed system outperforms the considered state-of-the-art approaches, granting accurate and reliable estimates. Moreover, the developed methodology constrains neither the number of persons to track, nor the number, position, synchronization, frame-rate, and manufacturer of the RGB-D cameras used. Finally, the real-time performances of the system are of paramount importance for a large number of real-world applications., Comment: Accepted to IEEE SMC 2019

Published
2019

89. GRAAL: Gem Reconstruction And Analysis Library

Author

Farinelli, R., Alexeev, M., Amoroso, A., Bagnasco, S., BaldiniFerroli, R., Balossino, I., Bertani, M., Bettoni, D., Bortone, A., Bianchi, F., Calcaterra, A., Cerioni, S., Chai, J., Cheng, W., Chiozzi, S., Cibinetto, G., Cossio, F., Ramusino, A. Cotta, Cotto, G., Rolo, M. Da Rocha, De Mori, F., Destefanis, M., Evangelisti, F., Fava, L., Felici, G., Gaido, L., Garzia, I., Gatta, M., Gramigna, G. Giraudo., Greco, M., Lavezzi, L., Lusso, S., Li, H., Maggiora, M., Malaguti, R., Mangoni, A., Marcello, S., Melchiorri, M., Mezzadri, G., Mignone, M., Pacetti, S., Patteri, P., Passalacqua, B., Rivetti, A., Savrie, M., Sosio, S., Spataro, S., Tskhadadze, E., Yan, L., and Wheadon, R. J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

MPGD are the new frontier in gas trackers. Among this kind of devices, theGEM chambers are widely used. The experimental signals acquired with the detector mustobviously be reconstructed and analysed. In this contribution, a new offline software to performreconstruction, alignment and analysis on the data collected with APV-25 and TIGER ASICswill be presented. GRAAL (Gem Reconstruction And Analysis Library) is able to measurethe performance of a MPGD detector with a strip segmented anode (presently). The code isdivided in three parts: reconstruction, where the hits are digitized and clusterized; tracking,where a procedure fits the points from the tracking system and uses that information to align thechamber with rotations and shifts; analysis, where the performance is evaluated (e.g. efficiency,spatial resolution,etc.). The user must set the geometry of the setup and then the programreturns automatically the analysis results, taking care of different conditions of gas mixture,electric field, magnetic field, geometries, strip orientation, dead strip, misalignment and manyothers.

Published
2019
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90. The NA62 GigaTracKer: a low mass high intensity beam 4D tracker with 65 ps time resolution on tracks

Author

Rinella, G. Aglieri, Feito, D. Alvarez, Arcidiacono, R., Biino, C., Bonacini, S., Ceccucci, A., Chiozzi, S., Gil, E. Cortina, Ramusino, A. Cotta, Danielsson, H., Degrange, J., Fiorini, M., Federici, L., Gamberini, E., Gianoli, A., Kaplon, J., Kleimenova, A., Kluge, A., Malaguti, R., Mapelli, A., Marchetto, F., Albarrán, E. Martín, Migliore, E., Minucci, E., Morel, M., Noël, J., Noy, M., Nüessle, G., Perktold, L., Perrin-Terrin, M., Petagna, P., Petrucci, F., Poltorak, K., Romagnoli, G., Ruggiero, G., Velghe, B., and Wahl, H.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The GigaTracKer (GTK) is the beam spectrometer of the CERN NA62 experiment. The detector features challenging design specifications, in particular a peak particle flux reaching up to 2.0 MHz/mm$^2$, a single hit time resolution smaller than 200 ps and, a material budget of 0.5% X$_0$ per tracking plane. To fulfill these specifications, novel technologies were especially employed in the domain of silicon hybrid time-stamping pixel technology and micro-channel cooling. This article describes the detector design and reports on the achieved performance.

Published
2019
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91. A fast and parametric digitization for triple-GEM detectors

Author

Farinelli, R., Alexeev, M., Amoroso, A., Bagnasco, S., Ferrioli, R. Baldini, Balossino, I., Bertani, M., Bettoni, D., Bortone, A., Bianchi, F., Calcaterra, A., Cerioni, S., Chai, J., Cheng, W., Chiozzi, S., Cibinetto, G., Cossio, F., Ramusino, A. Cotta, Cotto, G., Rolo, M. Da Rocha, De Mori, F., Destefanis, M., Evangelisti, F., Fava, L., Felici, G., Gaido, L., Garzia, I., Gatta, M., Giraudo, G., Gramigna, S., Greco, M., Lavezzi, L., Lusso, S., Li, H., Maggiora, M., Malaguti, R., Mangoni, A., Marcello, S., Melchiorri, M., Mezzadri, G., Mignone, M., Pacetti, S., Patteri, P., Passalacqua, B., Rivetti, A., Savri, M., Sosio, S., Spataro, S., Tskhadadze, E., Yan, L., and Wheadon, R. J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Triple-GEM detectors are a well known technology in high energy physics. In order to have a complete understanding of their behavior, in parallel with on beam testing, a Monte Carlo code has to be developed to simulate their response to the passage of particles. The software must take into account all the physical processes involved from the primary ionization up to the signal formation, e.g. the avalanche multiplication and the effect of the diffusion on the electrons. In the case of gas detectors, existing software such as Garfield already perform a very detailed simulation but are CPU time consuming. A description of a reliable but faster simulation is presented here: it uses a parametric description of the variables of interest obtained by suitable preliminary Garfield simulations and tuned to the test beam data. It can reproduce the real values of the charge measured by the strip, needed to reconstruct the position with the Charge Centroid method. In addition, particular attention was put to the simulation of the timing information, which permits to apply also the micro-Time Projection Chamber position reconstruction, for the first time on a triple-GEM. A comparison between simulation and experimental values of some sentinel variables in different conditions of magnetic field, high voltage settings and incident angle will be shown.

Published
2019
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92. Monte Carlo studies for the optimisation of the Cherenkov Telescope Array layout

Author

Acharyya, A., Agudo, I., Angüner, E. O., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amans, J. -P., Amati, L., Amato, E., Ambrosi, G., Antonelli, L. A., Aramo, C., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ashkar, H., Balazs, C., Balbo, M., Balmaverde, B., Barai, P., Barbano, A., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., González, J. Becerra, Tjus, J. Becker, Bellizzi, L., Benbow, W., Bernardini, E., Bernardos, M. I., Bernlöhr, K., Berti, A., Berton, M., Bertucci, B., Beshley, V., Biasuzzi, B., Bigongiari, C., Bird, R., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Bordas, P., Böttcher, M., Bregeon, J., Brill, A., Brown, A. M., Brügge, K., Brun, P., Bruno, P., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Cameron, R., Canestrari, R., Capalbi, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, R., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Catalano, O., Cauz, D., Cerruti, M., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Cieślar, M., Colak, S. M., Conforti, V., Congiu, E., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cumani, P., Cusumano, G., D'Aì, A., D'Ammando, F., Dangeon, L., Da Vela, P., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, De Frondat, F., Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., de Naurois, M., Wilhelmi, E. de Oña, de Palma, F., de Souza, V., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Díaz, C., Diebold, S., Djannati-Ataï, A., Dmytriiev, A., Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Dournaux, J. -L., Ebr, J., Ekoume, T. R. N., Elsässer, D., Emery, G., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Flis, S., Fonseca, M. V., Fontaine, G., Coromina, L. Freixas, Fukami, S., Fukui, Y., Funk, S., Füßling, M., Gaggero, D., Galanti, G., López, R. J. Garcia, Garczarczyk, M., Gascon, D., Gasparetto, T., Gaug, M., Ghalumyan, A., Gianotti, F., Giavitto, G., Giglietto, N., Giordano, F., Giroletti, M., Gironnet, J., Glicenstein, J. -F., Gnatyk, R., Goldoni, P., González, J. M., González, M. M., Gourgouliatos, K. N., Grabarczyk, T., Granot, J., Green, D., Greenshaw, T., Grondin, M. -H., Gueta, O., Hadasch, D., Hassan, T., Hayashida, M., Heller, M., Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hofmann, W., Horvath, P., Hrabovsky, M., Hrupec, D., Humensky, T. B., Hütten, M., Inada, T., Iocco, F., Ionica, M., Iori, M., Iwamura, Y., Jamrozy, M., Janecek, P., Jankowsky, D., Jean, P., Jouvin, L., Jurysek, J., Kaaret, P., Kadowaki, L. H. S., Karkar, S., Kerszberg, D., Khélifi, B., Kieda, D., Kimeswenger, S., Kluźniak, W., Knapp, J., Knödlseder, J., Kobayashi, Y., Koch, B., Kocot, J., Komin, N., Kong, A., Kowal, G., Krause, M., Kubo, H., Kushida, J., Kushwaha, P., La Parola, V., La Rosa, G., Arquillo, M. Lallena, Lang, R. G., Lapington, J., Blanc, O. Le, Lefaucheur, J., de Oliveira, M. A. Leigui, Lemoine-Goumard, M., Lenain, J. -P., Leto, G., Lico, R., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., Lopez-Oramas, A., López-Coto, R., Loporchio, S., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Mach, E., Maggio, C., Majumdar, P., Malaguti, G., Mallamaci, M., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Marculewicz, M., Mariotti, M., Martí, J., Martínez, M., Martínez, G., Martínez-Huerta, H., Masuda, S., Maxted, N., Mazin, D., Meunier, J. -L., Meyer, M., Micanovic, S., Millul, R., Minaya, I. A., Mitchell, A., Mizuno, T., Moderski, R., Mohrmann, L., Montaruli, T., Moralejo, A., Morcuende, D., Morlino, G., Morselli, A., Moulin, E., Mukherjee, R., Munar, P., Mundell, C., Murach, T., Nagai, A., Nagayoshi, T., Naito, T., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Ninci, D., Nishijima, K., Noda, K., Nosek, D., Nöthe, M., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Ostrowski, M., Otte, N., Ou, Z., Oya, I., Pagliaro, A., Palatiello, M., Palatka, M., Paoletti, R., Paredes, J. M., Pareschi, G., Parmiggiani, N., Parsons, R. D., Patricelli, B., Pe'er, A., Pech, M., Del Campo, P. Peñil, Pérez-Romero, J., Perri, M., Persic, M., Petrucci, P. -O., Petruk, O., Pfrang, K., Piel, Q., Pietropaolo, E., Pohl, M., Polo, M., Poutanen, J., Prandini, E., Produit, N., Prokoph, H., Prouza, M., Przybilski, H., Pühlhofer, G., Punch, M., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Reimer, O., Renault-Tinacci, N., Renier, Y., Ribeiro, D., Ribó, M., Rico, J., Rieger, F., Rizi, V., Fernandez, G. Rodriguez, Rodriguez-Ramirez, J. C., Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rowell, G., Rudak, B., Rugliancich, A., Rulten, C., Sadeh, I., Saha, L., Saito, T., Sakurai, S., Greus, F. Salesa, Sangiorgi, P., Sano, H., Santander, M., Santangelo, A., Santos-Lima, R., Sanuy, A., Satalecka, K., Saturni, F. G., Sawangwit, U., Schlenstedt, S., Schovanek, P., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Sedlaczek, K., Seglar-Arroyo, M., Sergijenko, O., Seweryn, K., Shalchi, A., Shellard, R. C., Siejkowski, H., Sillanpää, A., Sinha, A., Sironi, G., Sliusar, V., Slowikowska, A., Sol, H., Specovius, A., Spencer, S., Spengler, G., Stamerra, A., Stanič, S., Stawarz, Ł., Stefanik, S., Stolarczyk, T., Straumann, U., Suomijarvi, T., Świerk, P., Szepieniec, T., Tagliaferri, G., Tajima, H., Tam, T., Tavecchio, F., Taylor, L., Tejedor, L. A., Temnikov, P., Terzic, T., Testa, V., Tibaldo, L., Peixoto, C. J. Todero, Tokanai, F., Tomankova, L., Tonev, D., Torres, D. F., Tosti, G., Tosti, L., Tothill, N., Toussenel, F., Tovmassian, G., Travnicek, P., Trichard, C., Umana, G., Vagelli, V., Valentino, M., Vallage, B., Vallania, P., Valore, L., Vandenbroucke, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Vercellone, S., Vergani, S., Vettolani, G. P., Viana, A., Vigorito, C. F., Vink, J., Vitale, V., Voelk, H., Vollhardt, A., Vorobiov, S., Wagner, S. J., Walter, R., Werner, F., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Yang, L., Yoshida, T., Yoshikoshi, T., Zacharias, M., Zampieri, L., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zenin, A., Zhdanov, V. I., Zimmer, S., and Zorn, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Cherenkov Telescope Array (CTA) is the major next-generation observatory for ground-based very-high-energy gamma-ray astronomy. It will improve the sensitivity of current ground-based instruments by a factor of five to twenty, depending on the energy, greatly improving both their angular and energy resolutions over four decades in energy (from 20 GeV to 300 TeV). This achievement will be possible by using tens of imaging Cherenkov telescopes of three successive sizes. They will be arranged into two arrays, one per hemisphere, located on the La Palma island (Spain) and in Paranal (Chile). We present here the optimised and final telescope arrays for both CTA sites, as well as their foreseen performance, resulting from the analysis of three different large-scale Monte Carlo productions., Comment: 48 pages, 16 figures, accepted for publication in Astroparticle Physics

Published
2019
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93. Solar ultraviolet light collector for germicidal irradiation on the moon

Author

Lombini, Matteo, Schreiber, Laura, Albertini, Roberto, Alessi, Elisa Maria, Attinà, Primo, Bianco, Andrea, Cascone, Enrico, Colucci, Maria Eugenia, Cortecchia, Fausto, De Caprio, Vincenzo, Diolaiti, Emiliano, Fiorini, Mauro, Lessio, Luigi, Macchi, Alberto, Malaguti, Giuseppe, Mongelluzzo, Giuseppe, Pareschi, Giovanni, Pelizzo, Maria G., and Pasquarella, Cesira

Published
2023
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97. Quality of care in peripheral venous catheterization: A scoping review

Author

Saulo Pereira da Costa, Rodrigo Euripedes da Silveira, Damiana Aparecida Trindade Monteiro, Divanice Contim, and Silmara Elaine Malaguti Toffano

Subjects
Catheterization, Peripheral, Surveys and Questionnaires, Health Evaluation, Quality of Health Care, Review, Nursing, RT1-120
Abstract

ABSTRACT Objective: To map the current status of parameters and tools to assess quality of care related to peripheral venous catheter use in adults. Methods: Scoping review, conducted in 2022 in the MEDLINE, LILACS, CINAHL and SCOPUS databases and with a publication time limit from 2013 to 2022. Results: The sample consisted of 15 articles, summarized in the following categories: Indication, documentation and registration, coverage assessment, connection, stabilization and signs and symptoms inherent to the catheter. The use of a complete instrument, with the domains observed in this review, may have a positive impact on a more effective and safe clinical practice. Conclusions: The present review mapped the evidence about the insertion and maintenance of peripheral venous catheters that can be improved with training of good practices and the quality of the team, regarding the use of tools, materials and instruments for the evaluation of care.

Published
2023
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98. Children surviving war and Peace Education: goals for sustainable development

Author

Elena Malaguti

Subjects
education, peace, war, resilience, children, educazione, Education
Abstract

On the basis of the Universal Declaration of Human Rights (UDHR, 1948), the Convention on the Rights of Children and Adolescence (UN General Assembly, 1989), the Charter fundamental rights of the European Union (EU, 2000) and the Agenda 2030 Goals, the aim of this paper is to describes the topic of peace and war, through an inclusive education approach. The goal is to support, also in Italy, the growth process of minors who experience war’s conditions. The fight against violence and war, the promotion of education for peace are a specific need and work that must be undertaken with renewed strength and commitment in schools and in informal educational contexts. Bambini che sopravvivono alla guerra ed educazione alla pace: obiettivi per uno sviluppo sostenibile. Il presente contributo discute i temi della pace e della guerra nel quadro di un possibile approccio educativo volto ad accompagnare il processo di crescita di minori che sperimentano condizioni di guerra. Anche in luce della Dichiarazione Universale dei Diritti Umani (UDHR, 1948), della Convenzione sui Diritti dell’Infanzia e dell’Adolescenza (UN, 1989), richiamando i principi della Carta dei diritti fondamentali dell’Unione Europea (EU, 2000), volendo perseguire gli obiettivi dello sviluppo sostenibile, come promosso dall’Agenda 2030, il contrasto alla violenza, alla guerra e la sua prevenzione, la promozione di percorsi di pace sono un preciso dovere e impegno anche di chi assume compiti in campo educativo.

Published
2023
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99. A high-fat diet protects C57BL/6 mice from Plasmodium berghei ANKA infection in an experimental malaria study

Author

Sara Malaguti Andrade Soares, Ana Cristina Moura Gualberto, Augusto Cesar da Costa, Diego Assis Gonçalves, and Jacy Gameiro

Subjects
malaria, plasmodium, obesity, infection, high fat diet, hiperlipidic, Arctic medicine. Tropical medicine, RC955-962
Abstract

IntroductionIt is well known that dietary changes have a significant impact on the immune system, and modifications in lipid balance may contribute to disease progression in several cases. Malaria is still a major global health concern, and the development of the disease has already been linked to the host’s nutritional status, so it’s critical to understand how environmental factors, such as dietary variations, can influence the outcome of infection. We therefore investigated the effect of a short-term diet in a murine model of experimental cerebral malaria.MethodsFor this, male C57BL/6 mice were fed a high fat diet containing 60% of the calories from lipids for 5 days. Following this period, the animals were infected with Plasmodium berghei ANKA, and parasitemia, survival, and neurological scores were compared. Considering that one of the first elimination routes of the intracellular parasite is oxidative stress, the antioxidant N-acetylcysteine was administered to assess whether the protection would be reversed.Results and discussionAnimals fed a hyperlipidic diet reacted the same way to infection even after NAC administration. Unlike the control group, which died after eight days of infection with roughly 7% parasitized red blood cells, the hyperlipidic diet group was resistant to infection, with no clinical signs and no increase in blood parasitemia. Several proinflammatory cytokines such as TNF-α IFN-γ and IL-6 were increased in the spleen of both infected groups, regardless of their diet. The provision of a high-fat diet to mice for as little as 5 days completely prevents Plasmodium berghei ANKA infection in C57BL/6 mice, while the treatment of an antioxidant failed to reverse the parasite protection.

Published
2023
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100. Self-management interventions for people with pulmonary fibrosis: a scoping review

Author

Joanna Y.T. Lee, Gabriella Tikellis, Leona Dowman, Arwel W. Jones, Mariana Hoffman, Christie R. Mellerick, Carla Malaguti, Yet H. Khor, and Anne E. Holland

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Background The most effective method for encouraging self-management in individuals with pulmonary fibrosis (PF) is unclear. This review aimed to identify common self-management components, the outcome measures used and the impact of these components in PF. Methods A scoping review was conducted according to the Joanna Briggs Institute Manual for Evidence Synthesis using Medline, Embase, PsychInfo, CINAHL and the Cochrane Central Register of Controlled Trials. Eligible studies included those with educational, behavioural or support components aimed at facilitating self-management among adults with PF and employed quantitative and/or qualitative methods. Results 87 studies were included. Common self-management components included education (78%), managing physical symptoms (66%) and enhancing psychosocial wellbeing (54%). Components were predominantly delivered in a pulmonary rehabilitation setting (71%). No studies tested a PF-specific self-management package. Common outcome measures were 6-min walk distance (60%), St George's Respiratory Questionnaire (37%) and the Medical Research Council Dyspnoea scale (34%). Clinically significant improvements in these outcomes were seen in ≥50% of randomised controlled trials. Qualitative data highlighted the importance of healthcare professional and peer support and increased confidence in managing PF. Conclusion Self-management components are commonly incorporated into pulmonary rehabilitation programmes rather than being offered as standalone packages. Future research should focus on testing PF-specific self-management packages and employ standardised outcome assessments that include self-efficacy and health-related behaviours.

Published
2023
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