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51. Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals—The Uric Acid Right for Heart Health (URRAH) Project

Author

D’Elia, Lanfranco, primary, Masulli, Maria, additional, Cirillo, Pietro, additional, Virdis, Agostino, additional, Casiglia, Edoardo, additional, Tikhonoff, Valerie, additional, Angeli, Fabio, additional, Barbagallo, Carlo Maria, additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Ciccarelli, Michele, additional, Cicero, Arrigo F. G., additional, Cirillo, Massimo, additional, Dell’Oro, Raffaella, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masi, Stefano, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, Borghi, Claudio, additional, and Galletti, Ferruccio, additional

Published
2024
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52. Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (URRAH Project)

Author

D’Elia, Lanfranco, primary, Masulli, Maria, additional, Virdis, Agostino, additional, Casiglia, Edoardo, additional, Tikhonoff, Valerie, additional, Angeli, Fabio, additional, Barbagallo, Carlo Maria, additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Ciccarelli, Michele, additional, Cicero, Arrigo F G, additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’Oro, Raffaella, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masi, Stefano, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, Borghi, Claudio, additional, and Galletti, Ferruccio, additional

Published
2024
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53. The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study

Author

Ungar, Andrea, Rivasi, Giulia, Di Bari, Mauro, Virdis, Agostino, Casiglia, Edoardo, Masi, Stefano, Mengozzi, Alessandro, Barbagallo, Carlo M., Bombelli, Michele, Bruno, Bernardino, Cicero, Arrigo F.G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Ciccarelli, Michele, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Cianci, Rosario, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio

Published
2021
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55. Real-World Efficacy and Safety of Inclisiran: A Single-Country, Multicenter, Observational Study (CHOLINET Registry)

Author

Gargiulo, Paola, Marzano, Federica, Crisci, Mario, Marcucci, Rossella, Bruzzese, Dario, Maloberti, Alessandro, Sarullo, Filippo Maria, Galasso, Gennaro, Indolfi, Ciro, Musumeci, Giuseppe, Corleto, Antonella, Calabrò, Paolo, Carugo, Stefano, Casu, Gavino, Picciolo, Amedeo, Ciccone, Marco Matteo, Bilato, Claudio, Polimeni, Alberto, Giallauria, Francesco, Catalano, Angelo, De Luca, Leonardo, Niccoli, Giampaolo, Venturini, Elio, Pepe, Marco, Montisci, Roberta, Brunetti, Natale Daniele, Patti, Giuseppe, Porto, Italo, Margonato, Alberto, Floresta, Marina, Muscoli, Saverio, Cameli, Matteo, Andò, Giuseppe, Di Lorenzo, Emilio, Berteotti, Martina, Giannattasio, Cristina, Sarullo, Silvia, Formisano, Ciro, Di Costanzo, Assunta, Delnevo, Fabrizio, Varbella, Ferdinando, Cesaro, Arturo, Franzese, Monica, Mancusi, Costantino, Fontanarosa, Sara, Di Santo, Mariafrancesca, Cotticelli, Ciro, Perrone Filardi, Fabrizio, Paolillo, Stefania, Esposito, Giovanni, Corsini, Alberto, and Perrone Filardi, Pasquale

Published
2025
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56. Uric acid and metabolic syndrome: Importance of hyperuricemia cut-off

Author

Maloberti, A, Tognola, C, Garofani, I, Algeri, M, Shkodra, A, Bellantonio, V, Le Van, M, Pedroli, S, Campana, M, Toscani, G, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Tognola, Chiara, Garofani, Ilaria, Algeri, Michela, Shkodra, Atea, Bellantonio, Valentina, Le Van, Marco, Pedroli, Stefano, Campana, Marta, Toscani, Giorgio, Bombelli, Michele, Giannattasio, Cristina, Maloberti, A, Tognola, C, Garofani, I, Algeri, M, Shkodra, A, Bellantonio, V, Le Van, M, Pedroli, S, Campana, M, Toscani, G, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Tognola, Chiara, Garofani, Ilaria, Algeri, Michela, Shkodra, Atea, Bellantonio, Valentina, Le Van, Marco, Pedroli, Stefano, Campana, Marta, Toscani, Giorgio, Bombelli, Michele, and Giannattasio, Cristina

Abstract

Background: The relationship between HyperUricemia (HU) and Metabolic Sindrome (MS) and if Uric Acid (UA) should be inserted into MS definitions is a matter of debate. Aim of our study was to evaluate the correlation between UA and HU with Insulin Resistance (IR) and MS in a population of hypertensive patients. HU was defined with two cut-offs (the classic one of ≥6 mg/dL for women and ≥ 7 for men; the newly proposed URRAH one with ≥5.6 mg/dL for both sexes). Methods: We enrolled 473 Hypertensive patients followed by the Hypertension Unit of San Gerardo Hospital (Monza, Italy). IR was defined through TG/HDL ratio and NCEP-ATP-III criteria were used for MS diagnosis. Results: MS was found in 33.6 % while HU affected 14.8 % of subjects according to the traditional cut-off and 35.9 % with the URRAH cut-off. 9.7 % (traditional cut-off) and 17.3 % (URRAH's threshold) of the subjects had both HU and MS. UA level was significantly higher in MS group (5.7 vs 4.9 mg/dL, p < 0.0001) as well as for HU (29.0 vs 7.6 % and 51.6 vs 28.0 %, for classic and URRAH cut-off respectively, p < 0.0001 for both comparison). Logistic multivariable regression models showed that UA is related to MS diagnosis (OR = 1.608 for each 1 mg/dL), as well as HU with both cut-off (OR = 5.532 and OR = 3.379, p < 0.0001 for all comparison, for the classic cut-off and the URRAH one respectively). Conclusions: The main finding of our study is that UA and HU significantly relate to IR and MS. The higher the values of UA and the higher the cut-off used, the higher the strength of the relationship.

Published
2024

57. Results of a Telehealth Program in Patients with Cardiovascular Risk Factors in low and Middle-Income Countries

Author

Ciuffarella, C, Maloberti, A, Quarti-Trevano, F, Dell'Oro, R, Facchetti, R, Grassi, G, Ciuffarella, Claudia, Maloberti, Alessandro, Quarti-Trevano, Fosca, Dell'Oro, Raffaella, Facchetti, Rita, Grassi, Guido, Ciuffarella, C, Maloberti, A, Quarti-Trevano, F, Dell'Oro, R, Facchetti, R, Grassi, G, Ciuffarella, Claudia, Maloberti, Alessandro, Quarti-Trevano, Fosca, Dell'Oro, Raffaella, Facchetti, Rita, and Grassi, Guido

Published
2024

58. Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study

Author

Agabiti Rosei, C, Paini, A, Buso, G, Maloberti, A, Giannattasio, C, Salvetti, M, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Mengozzi, A, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Muiesan, M, Borghi, C, Agabiti Rosei, Claudia, Paini, Anna, Buso, Giacomo, Maloberti, Alessandro, Giannattasio, Cristina, Salvetti, Massimo, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo Francesco Giuseppe, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'Elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Muiesan, Maria Lorenza, Borghi, Claudio, Agabiti Rosei, C, Paini, A, Buso, G, Maloberti, A, Giannattasio, C, Salvetti, M, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Mengozzi, A, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Muiesan, M, Borghi, C, Agabiti Rosei, Claudia, Paini, Anna, Buso, Giacomo, Maloberti, Alessandro, Giannattasio, Cristina, Salvetti, Massimo, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo Francesco Giuseppe, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'Elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Muiesan, Maria Lorenza, and Borghi, Claudio

Abstract

High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been recently postulated. Subjects from the URic acid Right for heArt Health (URRAH) study with carotid ultrasound and without previous cardiovascular diseases (CVD) (n = 6209), followed over 20 years, were included in the analysis. Hypertriglyceridemia (hTG) was defined as TG ≥ 150 mg/dL. Higher levels of SUA (hSUA) were defined as ≥5.6 mg/dL in men and 5.1 mg/dL in women. A carotid plaque was identified in 1742 subjects (28%). SUA and TG predicted carotid plaque (HR 1.09 [1.04-1.27], p < 0.001 and HR 1.25 [1.09-1.45], p < 0.001) in the whole population, independently of age, sex, diabetes, systolic blood pressure, HDL and LDL cholesterol and treatment. Four different groups were identified (normal SUA and TG, hSUA and normal TG, normal SUA and hTG, hSUA and hTG). The prevalence of plaque was progressively greater in subjects with normal SUA and TG (23%), hSUA and normal TG (31%), normal SUA and hTG (34%), and hSUA and hTG (38%) (Chi-square, 0.0001). Logistic regression analysis showed that hSUA and normal TG [HR 1.159 (1.002 to 1.341); p = 0.001], normal SUA and hTG [HR 1.305 (1.057 to 1.611); p = 0.001], and the combination of hUA and hTG [HR 1.539 (1.274 to 1.859); p = 0.001] were associated with a higher risk of plaque. Our findings demonstrate that SUA is independently associated with the presence of carotid plaque and suggest that the combination of hyperuricemia and hypertriglyceridemia is a stronger determinant of carotid plaque than hSUA or hTG taken as single risk factors. The association between SUA and CVD events may be explained in part by a direct association of UA with carotid plaques.

Published
2024

59. Risk of Cardiovascular Events in Metabolically Healthy Overweight or Obese Adults: Role of LDL-Cholesterol in the Stratification of Risk

Author

Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Cianci, R, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Russo, E, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo Maria, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Cianci, Rosario, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Russo, Elisa, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, Borghi, Claudio, Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Cianci, R, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Russo, E, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo Maria, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Cianci, Rosario, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Russo, Elisa, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, and Borghi, Claudio

Abstract

The objective of this study was to investigate the longitudinal association of metabolically healthy overweight/obese adults with major adverse cardiovascular events (MACE) and the effect of LDL-cholesterol levels on this association. This study was conducted with 15,904 participants from the URRAH study grouped according to BMI and metabolic status. Healthy metabolic status was identified with and without including LDL-cholesterol. The risk of MACE during 11.8 years of follow-up was evaluated with multivariable Cox regressions. Among the participants aged <70 years, high BMI was associated with an increased risk of MACE, whereas among the older subjects it was associated with lower risk. Compared to the group with normal weight/healthy metabolic status, the metabolically healthy participants aged <70 years who were overweight/obese had an increased risk of MACE with an adjusted hazard ratio of 3.81 (95% CI, 1.34-10.85, p = 0.012). However, when LDL-cholesterol < 130 mg/dL was included in the definition of healthy metabolic status, no increase in risk was found in the overweight/obese adults compared to the normal weight individuals (hazard ratio 0.70 (0.07-6.71, p = 0.75). The present data show that the risk of MACE is increased in metabolically healthy overweight/obese individuals identified according to standard criteria. However, when LDL-cholesterol is included in the definition, metabolically healthy individuals who are overweight/obese have no increase in risk.

Published
2024

60. Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (Urrah Project)

Author

D'Elia, L, Masulli, M, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D'Elia, Lanfranco, Masulli, Maria, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Galletti, Ferruccio, D'Elia, L, Masulli, M, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D'Elia, Lanfranco, Masulli, Maria, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, and Galletti, Ferruccio

Abstract

Purpose: Recently, a novel index (triglyceride-glucose index-TyG) was considered a surrogate marker of insulin resistance (IR); in addition, it was estimated to be a better expression of IR than widely used tools. Few and heterogeneous data are available on the relationship between this index and mortality risk in non-Asian populations. Therefore, we estimated the predictive role of baseline TyG on the incidence of all-cause and cardiovascular (CV) mortality in a large sample of the general population. Moreover, in consideration of the well-recognized role of serum uric acid (SUA) on CV risk and the close correlation between SUA and IR, we also evaluated the combined effect of TyG and SUA on mortality risk. Methods: The analysis included 16,649 participants from the URRAH cohort. The risk of all-cause and CV mortality was evaluated by the Kaplan-Meier estimator and Cox multivariate analysis. Results: During a median follow-up of 144 months, 2569 deaths occurred. We stratified the sample by the optimal cut-off point for all-cause (4.62) and CV mortality (4.53). In the multivariate Cox regression analyses, participants with TyG above cut-off had a significantly higher risk of all-cause and CV mortality, than those with TyG below the cut-off. Moreover, the simultaneous presence of high levels of TyG and SUA was associated with a higher mortality risk than none or only one of the two factors. Conclusions: The results of this study indicate that these TyG (a low-cost and simple non-invasive marker) thresholds are predictive of an increased risk of mortality in a large and homogeneous general population. In addition, these results show a synergic effect of TyG and SUA on the risk of mortality.

Published
2024

61. Neurological hypertensive emergencies: Correlation of blood pressure values with in-hospital outcomes in ischemic stroke

Author

Giani, V, Valobra, T, Capsoni, N, Galasso, M, De Censi, L, Ferretti, C, Sultana, A, Giacalone, A, Garofani, I, Bombelli, M, Ceresa, C, Gheda, S, Agostoni, E, Galbiati, F, Giannattasio, C, Maloberti, A, Giani, Valentina, Valobra, Tommaso, Capsoni, Nicolò, Galasso, Michele, De Censi, Lorenzo, Ferretti, Cecilia, Sultana, Andrea, Giacalone, Annalisa, Garofani, Ilaria, Bombelli, Michele, Ceresa, Chiara, Gheda, Silvia, Agostoni, Elio Clemente, Galbiati, Filippo, Giannattasio, Cristina, Maloberti, Alessandro, Giani, V, Valobra, T, Capsoni, N, Galasso, M, De Censi, L, Ferretti, C, Sultana, A, Giacalone, A, Garofani, I, Bombelli, M, Ceresa, C, Gheda, S, Agostoni, E, Galbiati, F, Giannattasio, C, Maloberti, A, Giani, Valentina, Valobra, Tommaso, Capsoni, Nicolò, Galasso, Michele, De Censi, Lorenzo, Ferretti, Cecilia, Sultana, Andrea, Giacalone, Annalisa, Garofani, Ilaria, Bombelli, Michele, Ceresa, Chiara, Gheda, Silvia, Agostoni, Elio Clemente, Galbiati, Filippo, Giannattasio, Cristina, and Maloberti, Alessandro

Abstract

Background: Few certainties exist regarding optimal management of Blood Pressure (BP) in the very first hours after an ischemic stroke and many questions remain still unanswered. Our work aimed to evaluate the role of BP and its trend as possible determinants of in-hospital mortality (primary outcome), discharge disabilities and hospitalization length (secondary outcomes) in ischemic stroke patients presented with Hypertensive Emergencies (HE). Methods: We retrospectively evaluated patients presented to Niguarda Hospital, Emergency Department (ED), from 2015 to 2017 with a neurological ischemic HE. BP at ED presentation (T0), its management in ED (T1) and its values at the stroke unit admission (T2) were evaluated. Results: 267 patients were included (0.13 % of all ED accesses and 17.9 % of all ischemic strokes). In the whole population, BP values were not associated with in-hospital mortality while T0 and T2 SBP result were associated to discharge disability and hospitalization length. In pre-specified subgroup analysis these associations were confirmed only in untreated subjects (not anti-hypertensive nor thrombolysis). In fact, no significant relationship can be found between BP values and any secondary outcome in thrombolysis and anti-hypertensive treated patients. Conclusions: BP values and its management can not be related to in-hospital mortality in stroke patients, presented with HE, while they are associated to discharge disability and hospitalization length. In subgroup analysis, results were confirmed only in untreated (not anti-hypertensive therapies nor thrombolytic).

Published
2024

62. Long-term increase in serum uric acid and its predictors over a 25 year follow-up: Results of the PAMELA study

Author

Maloberti, A, Dell'Oro, R, Bombelli, M, Quarti-Trevano, F, Facchetti, R, Mancia, G, Grassi, G, Maloberti, Alessandro, Dell'Oro, Raffaella, Bombelli, Michele, Quarti-Trevano, Fosca, Facchetti, Rita, Mancia, Giuseppe, Grassi, Guido, Maloberti, A, Dell'Oro, R, Bombelli, M, Quarti-Trevano, F, Facchetti, R, Mancia, G, Grassi, G, Maloberti, Alessandro, Dell'Oro, Raffaella, Bombelli, Michele, Quarti-Trevano, Fosca, Facchetti, Rita, Mancia, Giuseppe, and Grassi, Guido

Abstract

Background and aims: Hyperuricemia (HU) has been shown to be associated with an adverse impact on cardiovascular and metabolic risk. Scanty data are available in the general population on the longitudinal changes in serum uric acid (SUA), the occurrence of HU and their potential predictors. We examined during a 25-year follow-up the SUA changes and the factors associated with HU development in the Pressioni Arteriose Monitorate E loro Associazioni (PAMELA) study. Methods and results: We analyzed data collected in 561 subjects of the PAMELA study evaluated during an average follow-up time amounting to 25.4 ± 1.0 years (mean ± SD). HU was defined by the Uric Acid Right for Heart Health (URRAh) cutoff (5.1 for females and 5.6 mg/dl for males). Mean SUA values during follow-up increased from 4.7 ± 1.1 to 5.0 ± 1.2 mg/dl (P<0.001), the average SUA elevation amounting to of 0.3 ± 1.1 mg/dl 26.7 % of the subjects displayed HU at the follow-up. This was associated at the multivariable analysis with female gender, office, home and 24-h blood pressure, diuretic treatment, serum triglycerides and baseline SUA, as well as the increase in waist circumference and the reduction in renal function. Conclusion: The present study provides longitudinal evidence that in the general population during a 25 year follow-up there is a progressive increase in SUA and HU development. Baseline SUA represents the most important factor associated with these modifications. Gender, renal dysfunction, triglycerides, obesity, diuretic treatment and blood pressure represent other variables capable to predict future occurrence of HU.

Published
2024

63. Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals—The Uric Acid Right for Heart Health (URRAH) Project

Author

D’Elia, L, Masulli, M, Cirillo, P, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Dell’Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D’Elia, Lanfranco, Masulli, Maria, Cirillo, Pietro, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Dell’Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Galletti, Ferruccio, D’Elia, L, Masulli, M, Cirillo, P, Virdis, A, Casiglia, E, Tikhonoff, V, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Dell’Oro, R, Desideri, G, Ferri, C, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masi, S, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Galletti, F, D’Elia, Lanfranco, Masulli, Maria, Cirillo, Pietro, Virdis, Agostino, Casiglia, Edoardo, Tikhonoff, Valerie, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Dell’Oro, Raffaella, Desideri, Giovambattista, Ferri, Claudio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, and Galletti, Ferruccio

Abstract

Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some studies explored the role of the serum creatinine (sCr)-normalized SUA (SUA/sCr) ratio in different settings. Previously, the URRAH (URic acid Right for heArt Health) Study has identified a cut-off value of this index to predict CV mortality at 5.35 Units. Therefore, given that no SUA/sCr ratio threshold for CV risk has been identified for patients with diabetes, we aimed to assess the relationship between this index and CV mortality and to validate this threshold in the URRAH subpopulation with diabetes; the URRAH participants with diabetes were studied (n = 2230). The risk of CV mortality was evaluated by the Kaplan–Meier estimator and Cox multivariate analysis. During a median follow-up of 9.2 years, 380 CV deaths occurred. A non-linear inverse association between baseline SUA/sCr ratio and risk of CV mortality was detected. In the whole sample, SUA/sCr ratio > 5.35 Units was not a significant predictor of CV mortality in diabetic patients. However, after stratification by kidney function, values > 5.35 Units were associated with a significantly higher mortality rate only in normal kidney function, while, in participants with overt kidney dysfunction, values of SUA/sCr ratio > 7.50 Units were associated with higher CV mortality. The SUA/sCr ratio threshold, previously proposed by the URRAH Study Group, is predictive of an increased risk of CV mortality in people with diabetes and preserved kidney function. While, in consideration of the strong association among kidney function, SUA, and CV mortality, a different cut-point was detected for diabetics with impaired kidney function. These data highlight the different predictive roles of SUA (and its interaction with kidney function) in CV risk, pointing out the difference in metabolic- and kidney-dependent SUA levels also in diabetic

Published
2024

64. Cardiovascular Structural and Functional Parameters in Idiopathic Pulmonary Fibrosis at Disease Diagnosis

Author

Faverio, P, Maloberti, A, Rebora, P, Intravaia, R, Tognola, C, Toscani, G, Amato, A, Leoni, V, Franco, G, Vitarelli, F, Spiti, S, Luppi, F, Valsecchi, M, Pesci, A, Giannattasio, C, Faverio, Paola, Maloberti, Alessandro, Rebora, Paola, Intravaia, Rita Cristina Myriam, Tognola, Chiara, Toscani, Giorgio, Amato, Anna, Leoni, Valerio, Franco, Giovanni, Vitarelli, Federica, Spiti, Simona, Luppi, Fabrizio, Valsecchi, Maria Grazia, Pesci, Alberto, Giannattasio, Cristina, Faverio, P, Maloberti, A, Rebora, P, Intravaia, R, Tognola, C, Toscani, G, Amato, A, Leoni, V, Franco, G, Vitarelli, F, Spiti, S, Luppi, F, Valsecchi, M, Pesci, A, Giannattasio, C, Faverio, Paola, Maloberti, Alessandro, Rebora, Paola, Intravaia, Rita Cristina Myriam, Tognola, Chiara, Toscani, Giorgio, Amato, Anna, Leoni, Valerio, Franco, Giovanni, Vitarelli, Federica, Spiti, Simona, Luppi, Fabrizio, Valsecchi, Maria Grazia, Pesci, Alberto, and Giannattasio, Cristina

Abstract

Introduction: Prevalence of cardiac and vascular fibrosis in patients with Idiopathic Pulmonary Fibrosis (IPF) has not been extensively evaluated. Aim: In this study, we aimed to evaluate the heart and vessels functional and structural properties in patients with IPF compared to healthy controls. An exploratory analysis regarding disease severity in IPF patients has been done. Methods: We enrolled 50 patients with IPF (at disease diagnosis before antifibrotic therapy initiation) and 50 controls matched for age and gender. Heart was evaluated through echocardiography and plasmatic NT-pro-brain natriuretic peptide that, together with patients’ symptoms, allow to define the presence of Heart Failure (HF) and diastolic dysfunction. Vessels were evaluated through Flow Mediated Dilation (FMD – endothelial function) and Pulse Wave Velocity (PWV—arterial stiffness) Results: Patients with IPF had a prevalence of diastolic disfunction of 83.8%, HF of 37.8% and vascular fibrosis of 76.6%. No statistically significant difference was observed in comparison to the control group who showed prevalence of diastolic disfunction, HF and vascular fibrosis of 67.3%, 24.5% and 84.8%, respectively. Disease severity seems not to affect PWV, FMD, diastolic dysfunction and HF. Conclusions: Patients with IPF early in the disease course do not present a significant CV fibrotic involvement when compared with age- and sex-matched controls. Bigger and adequately powered studies are needed to confirm our preliminary data and longitudinal studies are required in order to understand the time of appearance and progression rate of heart and vascular involvement in IPF subjects.

Published
2024

65. CAROTID-FEMORAL PULSE WAVE VELOCITY PROGRESSION IN HYPERTENSIVE PATIENTS IS ASSOCIATED WITH SUBSEQUENT CV OUTCOMES

Author

Maloberti, A, Rebora, P, Occhino, G, Andreano, A, Intravaia, R, Tognola, C, Toscani, G, Morelli, M, Pezzoli, S, D’Oro, L, Russo, A, Giannattasio, C, Maloberti, Alessandro, Rebora, Paola, Occhino, Giuseppe, Andreano, Anita, Intravaia, Rita Cristina My, Tognola, Chiara, Toscani, Giorgio, Morelli, Martina, Pezzoli, Stefano, D’Oro, Luca Cavalieri, Russo, Antonio, Giannattasio, Cristina, Maloberti, A, Rebora, P, Occhino, G, Andreano, A, Intravaia, R, Tognola, C, Toscani, G, Morelli, M, Pezzoli, S, D’Oro, L, Russo, A, Giannattasio, C, Maloberti, Alessandro, Rebora, Paola, Occhino, Giuseppe, Andreano, Anita, Intravaia, Rita Cristina My, Tognola, Chiara, Toscani, Giorgio, Morelli, Martina, Pezzoli, Stefano, D’Oro, Luca Cavalieri, Russo, Antonio, and Giannattasio, Cristina

Published
2024

66. EFFECT OF ANTI-PCSK9 ANTIBODIES ON ARTERY STRUCTURE AND FUNCTION: THE NIGUARDA HOSPITAL COHORT

Author

Maloberti, A, Toscani, G, Busti, A, Tognola, C, Intravaia, R, De Censi, L, Galasso, M, Daus, F, Giani, V, Gualini, E, Garofani, I, Riccio, A, Biolcati, M, Fabbri, S, Algeri, M, Merlini, P, Giannattasio, C, Morelli, M, Maloberti, Alessandro, Toscani, Giorgio, Busti, Andrea, Tognola, Chiara, Intravaia, Rita Cristina Mi, De Censi, Lorenzo, Galasso, Michele, Daus, Franesca, Giani, Valentina, Gualini, Elena, Garofani, Ilaria, Riccio, Alfonso, Biolcati, Marco, Fabbri, Saverio, Algeri, Michela, Merlini, Piera, Giannattasio, Cristina, Morelli, Martina, Maloberti, A, Toscani, G, Busti, A, Tognola, C, Intravaia, R, De Censi, L, Galasso, M, Daus, F, Giani, V, Gualini, E, Garofani, I, Riccio, A, Biolcati, M, Fabbri, S, Algeri, M, Merlini, P, Giannattasio, C, Morelli, M, Maloberti, Alessandro, Toscani, Giorgio, Busti, Andrea, Tognola, Chiara, Intravaia, Rita Cristina Mi, De Censi, Lorenzo, Galasso, Michele, Daus, Franesca, Giani, Valentina, Gualini, Elena, Garofani, Ilaria, Riccio, Alfonso, Biolcati, Marco, Fabbri, Saverio, Algeri, Michela, Merlini, Piera, Giannattasio, Cristina, and Morelli, Martina

Published
2024

67. HYPERTRIGLYCERIDEMIA IN PATIENTS WITH ACUTE AND CHRONIC CORONARY SYNDROME: PREVALENCE AND THEIR ASSOCIATION WITH EXTREME CARDIOVASCULAR RISK AND LEFT VENTRICULAR FUNCTION

Author

Maloberti, A, Rosa, A, Toscani, G, Caccia, A, Gualini, E, Pezzoli, S, Morelli, M, Busti, A, Colombo, V, Tognola, C, Algeri, M, Intravaia, R, Pirola, R, Giannattasio, C, Garofani, I, Maloberti, Alessandro, Rosa, Antonio La, Toscani, Giorgio, Caccia, Andrea, Gualini, Elena, Pezzoli, Stefano, Morelli, Martina, Busti, Andrea, Colombo, Valentina, Tognola, Chiara, Algeri, Michela, Intravaia, Rita Cristina My, Pirola, Roberto, Giannattasio, Cristina, Garofani, Ilaria, Maloberti, A, Rosa, A, Toscani, G, Caccia, A, Gualini, E, Pezzoli, S, Morelli, M, Busti, A, Colombo, V, Tognola, C, Algeri, M, Intravaia, R, Pirola, R, Giannattasio, C, Garofani, I, Maloberti, Alessandro, Rosa, Antonio La, Toscani, Giorgio, Caccia, Andrea, Gualini, Elena, Pezzoli, Stefano, Morelli, Martina, Busti, Andrea, Colombo, Valentina, Tognola, Chiara, Algeri, Michela, Intravaia, Rita Cristina My, Pirola, Roberto, Giannattasio, Cristina, and Garofani, Ilaria

Published
2024

68. HYPERTENSIVE EMERGENCIES AND URGENCIES: ADHERENCE TO GUIDELIENS AND RELATIONSHIP BETWEEN BLOOD PRESSURE MANAGEMENT AND IN-HOSPITAL MORTALITY

Author

Maloberti, A, Valobra, T, Giani, V, Garofani, I, De Censi, L, Galasso, M, Colombo, V, Menna, A, Giacalone, A, Ferretti, C, Sultana, A, Gheda, S, Capsoni, N, Galbiati, F, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Valobra, Tommaso, Giani, Valentina, Garofani, Ilaria, De Censi, Lorenzo, Galasso, Michele, Colombo, Valentina, Menna, Alessandro, Annalisa, Giacalone, Ferretti, Cecilia, Sultana, Andrea, Gheda, Silvia, Capsoni, Nicolò, Galbiati, Filippo, Bombelli, Michele, Giannattasio, Cristina, Maloberti, A, Valobra, T, Giani, V, Garofani, I, De Censi, L, Galasso, M, Colombo, V, Menna, A, Giacalone, A, Ferretti, C, Sultana, A, Gheda, S, Capsoni, N, Galbiati, F, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Valobra, Tommaso, Giani, Valentina, Garofani, Ilaria, De Censi, Lorenzo, Galasso, Michele, Colombo, Valentina, Menna, Alessandro, Annalisa, Giacalone, Ferretti, Cecilia, Sultana, Andrea, Gheda, Silvia, Capsoni, Nicolò, Galbiati, Filippo, Bombelli, Michele, and Giannattasio, Cristina

Published
2024

69. DIAGNOSTIC ACCURACY OF ATTENDED AND UNATTENDED BLOOD PRESSURE MEASUREMENTS IN PATIENTS WITH ARTERIAL HYPERTENSION

Author

Mancusi, C, Maloberti, A, Fucile, I, Manzi, M, Pengo, M, Bertacchini, F, Monticone, S, Pucci, G, Mancusi, Costantino, Maloberti, Alessandro, Fucile, Ilaria, Manzi, Maria Virigina, Pengo, Martino, Bertacchini, Fabio, Monticone, Silvia, Pucci, Giacomo, Mancusi, C, Maloberti, A, Fucile, I, Manzi, M, Pengo, M, Bertacchini, F, Monticone, S, Pucci, G, Mancusi, Costantino, Maloberti, Alessandro, Fucile, Ilaria, Manzi, Maria Virigina, Pengo, Martino, Bertacchini, Fabio, Monticone, Silvia, and Pucci, Giacomo

Published
2024

71. Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project

Author

Maloberti, Alessandro, Giannattasio, C., Bombelli, M., Desideri, G., Cicero, A. F. G., Muiesan, M. L., Rosei, E. A., Salvetti, M., Ungar, A., Rivasi, G., Pontremoli, R., Viazzi, F., Facchetti, R., Ferri, C., Bernardino, B., Galletti, F., D’Elia, L., Palatini, P., Casiglia, E., Tikhonoff, V., Barbagallo, C. M., Verdecchia, P., Masi, S., Mallamaci, F., Cirillo, M., Rattazzi, M., Pauletto, P., Cirillo, P., Gesualdo, L., Mazza, A., Volpe, M., Tocci, G., Iaccarino, G., Nazzaro, P., Lippa, L., Parati, G., Dell’Oro, R., Quarti-Trevano, F., Grassi, G., Virdis, A., and Borghi, C.

Published
2020
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74. Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals

Author

Weber, Thomas, Protogerou, Athanase D., Agharazii, Mohsen, Argyris, Antonis, Aoun Bahous, Sola, Banegas, Jose R., Binder, Ronald K., Blacher, Jacques, Araujo Brandao, Andréa, Cruz, Juan J., Danninger, Kathrin, Giannatasio, Cristina, Graciani, Auxiliadora, Hametner, Bernhard, Jankowski, Piotr, Li, Yan, Maloberti, Alessandro, Mayer, Christopher C., McDonnell, Barry J., McEniery, Carmel M., Antonio Mota Gomes, Marco, Machado Gomes, Annelise, Lorenza Muiesan, Maria, Nemcsik, Janos, Paini, Anna, Rodilla, Enrique, Schutte, Aletta E., Sfikakis, Petros P., Terentes-Printzios, Dimitrios, Vallée, Alexandre, Vlachopoulos, Charalambos, Ware, Lisa, Wilkinson, Ian, Zweiker, Robert, Sharman, James E., and Wassertheurer, Siegfried

Published
2022
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75. Heart Failure with Preserved Ejection Fraction: How to Deal with This Chameleon

Author

Lucà, Fabiana, primary, Oliva, Fabrizio, additional, Abrignani, Maurizio Giuseppe, additional, Di Fusco, Stefania Angela, additional, Gori, Mauro, additional, Giubilato, Simona, additional, Ceravolo, Roberto, additional, Temporelli, Pier Luigi, additional, Cornara, Stefano, additional, Rao, Carmelo Massimiliano, additional, Caretta, Giorgio, additional, Pozzi, Andrea, additional, Binaghi, Giulio, additional, Maloberti, Alessandro, additional, Di Nora, Concetta, additional, Di Matteo, Irene, additional, Pilleri, Anna, additional, Gelsomino, Sandro, additional, Riccio, Carmine, additional, Grimaldi, Massimo, additional, Colivicchi, Furio, additional, and Gulizia, Michele Massimo, additional

Published
2024
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76. Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large Regional‐Based Italian Database

Author

Tikhonoff, Valérie, primary, Casiglia, Edoardo, additional, Virdis, Agostino, additional, Grassi, Guido, additional, Angeli, Fabio, additional, Arca, Marcello, additional, Barbagallo, Carlo M., additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Cicero, Arrigo F. G., additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell'oro, Raffaella, additional, D'elia, Lanfranco, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Iaccarino, Guido, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masi, Stefano, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti‐Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Temporelli, Pier Luigi, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, and Borghi, Claudio, additional

Published
2024
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78. Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study

Author

Maloberti, Alessandro, Bombelli, Michele, Facchetti, Rita, Barbagallo, Carlo Maria, Bernardino, Bruno, Rosei, Enrico Agabiti, Casiglia, Edoardo, Giuseppe Cicero, Arrigo Francesco, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’elia, Lanfranco, Dell’Oro, Raffaella, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Loreto, Gesualdo, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, and Borghi, Claudio

Published
2020
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83. Management of Patients Treated with Direct Oral Anticoagulants in Clinical Practice and Challenging Scenarios

Author

Lucà, Fabiana, primary, Oliva, Fabrizio, additional, Abrignani, Maurizio Giuseppe, additional, Di Fusco, Stefania Angela, additional, Parrini, Iris, additional, Canale, Maria Laura, additional, Giubilato, Simona, additional, Cornara, Stefano, additional, Nesti, Martina, additional, Rao, Carmelo Massimiliano, additional, Pozzi, Andrea, additional, Binaghi, Giulio, additional, Maloberti, Alessandro, additional, Ceravolo, Roberto, additional, Bisceglia, Irma, additional, Rossini, Roberta, additional, Temporelli, Pier Luigi, additional, Amico, Antonio Francesco, additional, Calvanese, Raimondo, additional, Gelsomino, Sandro, additional, Riccio, Carmine, additional, Grimaldi, Massimo, additional, Colivicchi, Furio, additional, and Gulizia, Michele Massimo, additional

Published
2023
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85. Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study

Author

Muiesan, Maria L., Salvetti, Massimo, Virdis, Agostino, Masi, Stefano, Casiglia, Edoardo, Tikhonoff, Valérie, Barbagallo, Carlo M., Bombelli, Michele, Cicero, Arrigo F.G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Eliak, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Rattazzi, Marcello, Rivasi, Giulia, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio

Published
2021
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86. Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

Author

Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Masi, Stefano, Barbagallo, Carlo M., Bombelli, Michele, Bruno, Bernardino, Cicero, Arrigo F.G., Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio

Published
2020
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89. PROGNOSTIC VALUE AND RELATIVE CUT-OFFS OF TRIGLYCERIDES PREDICTING CARDIOVASCULAR OUTCOME IN A LARGE REGIONAL-BASED ITALIAN DATABASE

Author

Tikhonoff, Valérie, primary, Casiglia, Edoardo, additional, Virdis, Agostino, additional, Grassi, Guido, additional, Angeli, Fabio, additional, Arca, Marcello, additional, Barbagallo, Carlo M., additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Cianci, Rosario, additional, Cicero, Arrigo FG, additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’oro, Raffaella, additional, D’elia, Lanfranco, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Iaccarino, Guido, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masi, Stefano, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Temporelli, Pier Luigi, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, and Borghi, Claudio, additional

Published
2023
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90. SEVERE-1 STUDY PROTOCOL: SECONDARY PREVENTION AND EXTREME CARDIOVASCULAR RISK EVALUATION, FOCUS ON PREVALENCE AND ASSOCIATED RISK FACTORS

Author

Maloberti, Alessandro, primary, Intravaia, Rita, additional, Mancusi, Costantino, additional, Luca, Nicola De, additional, Golia, Enrica, additional, Cesaro, Arturo, additional, Chiara, Benedetta Carla De, additional, Bernasconi, Davide, additional, Algeri, Michela, additional, Grasso, Alice, additional, and Giannattasio, Cristina, additional

Published
2023
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94. Natural history and clinical burden of moderate aortic stenosis: a systematic review and explorative meta-analysis

Author

Morelli, M, Galasso, M, Esposito, G, Soriano, F, Nava, S, Da Pozzo, C, Bossi, I, Piccaluga, E, Bruschi, G, Maloberti, A, Oliva, F, Oreglia, J, Giannattasio, C, Montalto, C, Morelli, Martina, Galasso, Michele, Esposito, Giuseppe, Soriano, Francesco Stefano, Nava, Stefano, Da Pozzo, Caterina, Bossi, Irene, Piccaluga, Emanuela, Bruschi, Giuseppe, Maloberti, Alessandro, Oliva, Fabrizio, Oreglia, Jacopo Andrea, Giannattasio, Cristina, Montalto, Claudio, Morelli, M, Galasso, M, Esposito, G, Soriano, F, Nava, S, Da Pozzo, C, Bossi, I, Piccaluga, E, Bruschi, G, Maloberti, A, Oliva, F, Oreglia, J, Giannattasio, C, Montalto, C, Morelli, Martina, Galasso, Michele, Esposito, Giuseppe, Soriano, Francesco Stefano, Nava, Stefano, Da Pozzo, Caterina, Bossi, Irene, Piccaluga, Emanuela, Bruschi, Giuseppe, Maloberti, Alessandro, Oliva, Fabrizio, Oreglia, Jacopo Andrea, Giannattasio, Cristina, and Montalto, Claudio

Abstract

Aims: The mortality risk of patients with moderate aortic stenosis is not well known, but recent studies suggested that it might negatively affect prognosis. We aimed to assess the natural history and clinical burden of moderate aortic stenosis and to investigate the interaction of patients' baseline characteristics with prognosis. Methods: Systematic research was conducted on PubMed. The inclusion criteria were inclusion of patients with moderate aortic stenosis; and report of the survival at 1-year follow-up (minimum). Incidence ratios related to all-cause mortality in patients and controls of each study were estimated and then pooled using a fixed effects model. All patients with mild aortic stenosis or without aortic stenosis were considered controls. Meta-regression analysis was performed to assess the impact of left ventricular ejection fraction and age on the prognosis of patients with moderate aortic stenosis. Results: Fifteen studies and 11 596 patients with moderate aortic stenosis were included. All-cause mortality was significantly higher among patients with moderate aortic stenosis than in controls in all timeframes analysed (all P < 0.0001). Left ventricular ejection fraction and sex did not significantly impact on the prognosis of patients with moderate aortic stenosis (P = 0.4584 and P = 0.5792), while increasing age showed a significant interaction with mortality (estimate = 0.0067; 95% confidence interval: 0.0007-0.0127; P = 0.0323). Conclusion: Moderate aortic stenosis is associated with reduced survival. Further studies are necessary to confirm the prognostic impact of this valvulopathy and the possible benefit of aortic valve replacement.

Published
2023

95. The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Author

Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, Borghi, Claudio, Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, and Borghi, Claudio

Abstract

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

Published
2023

96. Impact of the Increase in Left Ventricular Mass on the Risk of Long-Term Cardiovascular Mortality: A Prospective Cohort Study

Author

Bombelli, M, Vanoli, J, Facchetti, R, Maloberti, A, Cuspidi, C, Grassi, G, Mancia, G, Bombelli, Michele, Vanoli, Jennifer, Facchetti, Rita, Maloberti, Alessandro, Cuspidi, Cesare, Grassi, Guido, Mancia, Giuseppe, Bombelli, M, Vanoli, J, Facchetti, R, Maloberti, A, Cuspidi, C, Grassi, G, Mancia, G, Bombelli, Michele, Vanoli, Jennifer, Facchetti, Rita, Maloberti, Alessandro, Cuspidi, Cesare, Grassi, Guido, and Mancia, Giuseppe

Abstract

Background: Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular events, and evidence has been obtained that an increase of a normal left ventricular mass (LVM) or new-onset LVH over time augments cardiovascular outcomes. Methods: We addressed this issue in a sample of a general population at relatively low cardiovascular risk. We analyzed subjects with normal echocardiographic LVM enrolled in the PAMELA (Pressioni Arteriose Monitorate E Loro Associazioni) study to follow the increase of LVM over time and assess the prognostic impact of this change on the incidence of cardiovascular events (mean follow-up 18.5 years). Results: In 990 subjects with no LVH at baseline, there was a significant average increase of LVM (21.2%), LVMIBSA(18.9%), and LVMIHT(22.3%) more than 10 years later. About a quarter developed LVH. The LVMIBSAchange exhibited an association with the cardiovascular risk mortality during the following 18.5 years, and the association remained significant after adjustment for confounders (hazard ratio, 1.2 [1.0-1.5]). Similar findings were obtained for LVM in absolute values or indexed for height. The association was seen in both genders, but the link with the cardiovascular risk was statistically significant in males only. Conclusions: Thus, although over 10 years, the LVM increase does not reach a LVH status, it is associated with an augmented cardiovascular mortality risk. This suggests that it might be important to consider periodical LVM assessment, even when LVM is within the normal range, to timely detect its increase and cope with the need of cardiovascular risk restratification.

Published
2023

97. Elevated Serum Urea-to-Creatinine Ratio and In-Hospital Death in Patients with Hyponatremia Hospitalized for COVID-19

Author

Regolisti, G, Rebora, P, Occhino, G, Lieti, G, Molon, G, Maloberti, A, Algeri, M, Giannattasio, C, Valsecchi, M, Genovesi, S, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Lieti, Giulia, Molon, Giulio, Maloberti, Alessandro, Algeri, Michela, Giannattasio, Cristina, Valsecchi, Maria Grazia, Genovesi, Simonetta, Regolisti, G, Rebora, P, Occhino, G, Lieti, G, Molon, G, Maloberti, A, Algeri, M, Giannattasio, C, Valsecchi, M, Genovesi, S, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Lieti, Giulia, Molon, Giulio, Maloberti, Alessandro, Algeri, Michela, Giannattasio, Cristina, Valsecchi, Maria Grazia, and Genovesi, Simonetta

Abstract

Hyponatremia is associated with adverse outcomes in hospitalized patients. An elevated value of the serum urea-to-creatinine ratio (UCR) has been proposed as a proxy of hypovolemia. The aim of this study was to investigate the relationship between the UCR and in-hospital death in patients hospitalized with COVID-19 and hyponatremia. We studied 258 patients admitted for COVID-19 between January 2020 and May 2021 with serum sodium at < 135 mmol/L. The primary end-point was all-cause mortality. A 5-unit increase in the serum UCR during hospital stays was associated with an 8% increase in the hazard of all-cause death (HR = 1.08, 95% CI: 1.03–1.14, p = 0.001) after adjusting for potential confounders. In patients with a UCR > 40 at baseline, a > 10 mmol/L increase in serum sodium values within the first week of hospitalization was associated with higher odds of in-hospital death (OR = 2.93, 95% CI: 1.03–8.36, p = 0.044) compared to patients who experienced a < 10 mmol/L change. This was not observed in patients with a UCR < 40. Hypovolemia developing during hospital stays in COVID-19 patients with hyponatremia detected at hospital admission bears an adverse prognostic impact. Moreover, in hypovolemic patients, a > 10 mmol/L increase in serum sodium within the first week of hospital stays may further worsen the in-hospital prognosis.

Published
2023

98. Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

Author

Mengozzi, A, Pugliese, N, Desideri, G, Masi, S, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell’Oro, R, D’Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Virdis, A, Mengozzi, Alessandro, Pugliese, Nicola Riccardo, Desideri, Giovambattista, Masi, Stefano, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Dell’Oro, Raffaella, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Virdis, Agostino, Mengozzi, A, Pugliese, N, Desideri, G, Masi, S, Angeli, F, Barbagallo, C, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell’Oro, R, D’Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Grassi, G, Iaccarino, G, Lippa, L, Mallamaci, F, Maloberti, A, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Russo, E, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Virdis, A, Mengozzi, Alessandro, Pugliese, Nicola Riccardo, Desideri, Giovambattista, Masi, Stefano, Angeli, Fabio, Barbagallo, Carlo Maria, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cicero, Arrigo F. G., Cirillo, Massimo, Cirillo, Pietro, Dell’Oro, Raffaella, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, and Virdis, Agostino

Abstract

High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan–Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12–1.40], p < 0.001) and CVM (1.31 [1.11–1.74], p < 0.001) in the whole study population, and according to TG strata: ACM in normotriglyceridemia (HR 1.26 [1.12–1.43], p < 0.001) and hypertriglyceridemia (1.31 [1.02–1.68], p = 0.033), and CVM in normotriglyceridemia (HR 1.46 [1.23–1.73], p < 0.001) and hypertriglyceridemia (HR 1.31 [0.99–1.64], p = 0.060). Exploratory and sensitivity analyses confirmed our findings, suggesting a substantial role of SUA in normotriglyceridemia and hypertriglyceridemia. In conclusion, we report that SUA can predict ACM and CVM in cardiometabolic patients without established cardiovascular disease, independent of TG levels.

Published
2023

99. Lipoprotein(a): Cardiovascular Disease, Aortic Stenosis and New Therapeutic Option

Author

Maloberti, A, Fabbri, S, Colombo, V, Gualini, E, Monticelli, M, Daus, F, Busti, A, Galasso, M, De Censi, L, Algeri, M, Merlini, P, Giannattasio, C, Maloberti, Alessandro, Fabbri, Saverio, Colombo, Valentina, Gualini, Elena, Monticelli, Massimiliano, Daus, Francesca, Busti, Andrea, Galasso, Michele, De Censi, Lorenzo, Algeri, Michela, Merlini, Piera Angelica, Giannattasio, Cristina, Maloberti, A, Fabbri, S, Colombo, V, Gualini, E, Monticelli, M, Daus, F, Busti, A, Galasso, M, De Censi, L, Algeri, M, Merlini, P, Giannattasio, C, Maloberti, Alessandro, Fabbri, Saverio, Colombo, Valentina, Gualini, Elena, Monticelli, Massimiliano, Daus, Francesca, Busti, Andrea, Galasso, Michele, De Censi, Lorenzo, Algeri, Michela, Merlini, Piera Angelica, and Giannattasio, Cristina

Abstract

Atherosclerosis is a chronic and progressive inflammatory process beginning early in life with late clinical manifestation. This slow pathological trend underlines the importance to early identify high-risk patients and to treat intensively risk factors to prevent the onset and/or the progression of atherosclerotic lesions. In addition to the common Cardiovascular (CV) risk factors, new markers able to increase the risk of CV disease have been identified. Among them, high levels of Lipoprotein(a)—Lp(a)—lead to very high risk of future CV diseases; this relationship has been well demonstrated in epidemiological, mendelian randomization and genome-wide association studies as well as in meta-analyses. Recently, new aspects have been identified, such as its association with aortic stenosis. Although till recent years it has been considered an unmodifiable risk factor, specific drugs have been developed with a strong efficacy in reducing the circulating levels of Lp(a) and their capacity to reduce subsequent CV events is under testing in ongoing trials. In this paper we will review all these aspects: from the synthesis, clearance and measurement of Lp(a), through the findings that examine its association with CV diseases and aortic stenosis to the new therapeutic options that will be available in the next years.

Published
2023

100. Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level

Author

Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, Borghi, Claudio, Palatini, P, Virdis, A, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Parati, G, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Masulli, M, Verdecchia, P, Reboldi, G, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Virdis, Agostino, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Parati, Gianfranco, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Masulli, Maria, Verdecchia, Paolo, Reboldi, Gianpaolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, and Borghi, Claudio

Abstract

Background and aims: Whether the association between very high HDL-cholesterol levels and cardiovascular mortality (CVM) is modulated by some facilitating factors is unclear. Aim of the study was to investigate whether the risk of CVM associated with very high HDL-cholesterol is increased in subjects with hyperuricemia. Methods and results: Multivariable Cox analyses were made in 18,072 participants from the multicentre URRAH study stratified by sex and HDL-cholesterol category. During a median follow-up of 11.4 years there were 1307 cases of CVM. In multivariable Cox models a J-shaped association was found in the whole population, with the highest risk being present in the high HDL-cholesterol group [>80 mg/dL, adjusted hazard ratio (HR), 1.28; 95%CI, 1.02–1.61; p = 0.031)]. However, a sex-specific analysis revealed that this association was present only in women (HR, 1.34; 95%CI, 1.02–1.77; p = 0.034) but not in men. The risk of CVM related to high HDL-cholesterol was much greater in the women with high uric acid (>0.30 mmol/L, HR 1.61; 95%CI, 1.08–2.39) than in those with low uric acid (HR, 1.17; 95%CI, 0.80–1.72, p for interaction = 0.016). In women older than 70 years with hyperuricemia the risk related to high HDL-cholesterol was 1.83 (95%CI, 1.19–2.80, p < 0.005). Inclusion of BMI in the models weakened the strength of the associations. Conclusion: Our data indicate that very high HDL-cholesterol levels in women are associated with CVM in a J-shaped fashion. The risk of CVM is increased by concomitant hyperuricemia suggesting that a proinflammatory/oxidative state can enhance the detrimental cardiovascular effects associated with high HDL-cholesterol.

Published
2023

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