51. Histamine-secreting microbes are increased in the gut of adult asthma patients
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Cezmi A. Akdis, Remo Frei, Ruth Ferstl, Benoit Pugin, Marek Jutel, Patrick Westermann, David Michalovich, Edith M. Hessel, Noelia Rodriguez Perez, Liam O'Mahony, Marcin Wawrzyniak, Weronika Barcik, Sylwia Smolinska, and University of Zurich
- Subjects
Adult ,Male ,0301 basic medicine ,Immunology ,610 Medicine & health ,Feces ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,10183 Swiss Institute of Allergy and Asthma Research ,medicine ,Humans ,Immunology and Allergy ,Asthma ,2403 Immunology ,Histamine metabolism ,business.industry ,Gastrointestinal Microbiome ,Case-control study ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,3. Good health ,respiratory tract diseases ,030104 developmental biology ,030228 respiratory system ,chemistry ,Case-Control Studies ,Host-Pathogen Interactions ,2723 Immunology and Allergy ,bacteria ,Female ,business ,Histamine - Abstract
Alterations in the metabolites (i.e. histamine) derived from the gut microbiome may influence host immune responses. Histamine secreting microbes are increased in the gut microbiome of adult asthma patients and histamine from these microbes may contribute to the effector responses in atopic asthma patients. Histamine secreting Escherichia coli Lactobacillus vaginalis and Morganella morganii strains were isolated from the gut microbiome of asthma patients.
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