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Background The Department of Pharmacy of the University Hospital of Ferrara (AOUFE) activated a project called ‘Monitoring and use of the Reference Centre for antidote stocks’. The project followed the correct allocation of available antidotes to the Reference Centre of the Emilia Romagna Region (ERR). Purpose Epidemiological analysis to identify different types of intoxication and check that they have been treated successfully. Materials and methods All 17 Hospitals of the ERR were asked to provide information about episodes of intoxication recorded from 1/1/2005 to 31/12/2009 as well as the antidote treatments administered. Required data were: year, type of intoxication and toxic substance, patient demographic data, type of antidote used and treatment period. Results 16 hospitals took part in the analysis. 8151 intoxications were recorded and they are grouped as follows: 1704 intoxications in 2005 (21% of the 5-year total); 1523 in 2006 (19%); 1593 in 2007 (20%); 1560 in 2008 (19%); 1771 in 2009 (21%). Categorisation by toxic substance showed the following: 31% caused by drugs; 17% caused by ethanol; 4% by opioids; 3% by carbon monoxide; 3% by food; 1% by sodium hypochlorite and derivatives; 36% by non-classifiable intoxications; 5% by various intoxications. The authors only evaluated complete intoxication data (1223 cases) and The authors had calculated in 80% of these cases the following antidotes were used: 19% (232/1223) activated charcoal associated with gastric lavage; 11% (132/1223) activated charcoal; 9% (109/1223) activated charcoal associated with MgSO 4 ; 12% (144/1223) flumazenil; 6% (76/1223) hyperbaric oxygen; 12% (151/1223) naloxone; 7% (80/1223) metadoxine; 4% (53/1223) benzodiazepines. Conclusions Drug and ethanol poisonings were the most frequent; non-specific treatments were the most frequently performed, followed by the use of specific antidotes such as flumazenil and naloxone. Epidemiological analysis shows that the frequency of intoxications in ERR is 3.82 per 10000 inhabitants/year.

Background The Department of Pharmacy of the University Hospital of Ferrara (AOUFE) has been appointed Regional Centre of Reference for the supply of some antidotes by the Region Emilia Romagna (RER). In order to assess their availability, a qualitative-quantitative assessment of antidotes available in regional hospitals was carried out. Purpose The authors looked particularly at antidotes supposed to be used within 30 min, (type A antidotes) which should be available in all hospitals. Materials and methods All 17 regional hospitals were asked for information about the kind and the quantity of antidotes stocked. The number of potential poisoning victims treatable with the quantity in stock was calculated based on the maximum dosage. Results All 17 regional hospitals provided the required information with the following results. Of the 27 type A antidotes The authors investigated, the stock for the maximum treatment of one patient was the following: 2 antidotes (activated charcoal, ipecacuanha) were available in 16 hospitals; 4 antidotes (atropine sulphate, calcium gluconate, physiostigmine and protamine sulphate) were available in 15 hospitals, and methylene blue was available in 14 hospitals. Eleven type A antidotes (pyridoxine, hydroxocobalamin, sodium bicarbonate, dantrolene, calcium folinate, polyethylene glycol 4000, MgSo 4 , diazepam, Fuller9s earth, digoxin-specific antibodies, polyethylene glycol 4000, fomepizole) were available in fewer than 10 hospitals. Glucagon was not present in any hospital to treat a patient. Conclusions Quantities of some antidotes available in regional hospitals were not sufficient to treat a single patient. This was the case for fomepizole, digoxin-specific antibodies and Fuller9s earth among type A antidotes, and for Prussian blue, dimercaprol and pralidoxime among type B antidotes. Therefore, the need to provide many regional hospitals with higher stocks of antidotes is recognised.

Considering the clinical significance for myocarditis and pericarditis after immunization with mRNA COVID-19 vaccines, the present pharmacovigilance study aimed to describe these events reported with mRNA COVID-19 vaccines in the Vaccine Adverse Events Reporting System (VAERS). From 1990 to July 2021, the mRNA vaccines were the most common suspected vaccines related to suspected cases of myocarditis and/or pericarditis (myocarditis: N = 1,165; 64.0%; pericarditis: N = 743; 55.1%), followed by smallpox vaccines (myocarditis: N = 222; 12.2%; pericarditis: N = 200; 14.8%). We assessed all suspected cases through the case definition and classification of the Brighton Collaboration Group, and only definitive, probable, and possible cases were included in the analysis. Our findings suggested that myocarditis and pericarditis mostly involve young male, especially after the second dose with a brief time to onset. Nevertheless, this risk is lower (0.38/100,000 vaccinated people; 95% CI 0.36–0.40) than the risk of developing myocarditis after SARS-CoV-2 infection (1000–4000 per 100,000 people) and the risk of developing “common” viral myocarditis (1–10 per 100,000 people/year). Comparing with the smallpox vaccine, for which is already well known the association with myocarditis and pericarditis, our analysis showed a lower probability of reporting myocarditis (ROR 0.12, 95% CI 0.10–0.14) and pericarditis (ROR 0.06, 95% CI 0.05–0.08) following immunization with mRNA COVID-19 vaccines.

We perform an optical characterization of UV laser ablated silicates (olivine, pyroxene), starting from their reflectance spectra in the 0.3–2.5 μm spectral range. The goal is to provide useful tools to model space weathering effects on surfaces of asteroids and TNOs (trans-neptunian objects). We determine that the reddening and darkening spectral trend is compatible with the Hapke's space weathering model, using the optical constants of metallic iron in a silicate matrix. This result is supported by new magnetic susceptibility measurements on laser ablated orthopyroxene. We also investigate the potential contribution of formation of amorphous silicates in the process. Applying our results to silicate-rich surfaces in the Solar System, we investigate the possibility of a weathered olivine component on the surface of Centaur 5145 Pholus. Inclusion of this component slightly decreases the amount of complex organics and water ice from those previously estimated. Thus, the current Pholus spectrum is consistent with the presence of either unweathered or weathered olivine, or potentially both materials.

Hematite is an iron oxide very important for the study of climatic evolution of Mars. It can occur in two forms: red and grey, mainly depending on the granulometry of the samples. Spectra of bright regions of Mars suggest the presence of red hematite particles. Moreover the Thermal Emission Spectrometer (TES), on board the Mars Global Surveyor mission, has discovered a deposit of crystalline grey hematite in Sinus Meridiani. TES spectra of that Martian region exhibit features at about 18, 23 and 33 μm that are consistent with hematite. Coarse grey hematite is considered strong evidence for longstanding water, while it is unknown whether the formation of fine-grained red hematite requires abundant water. Studies are needed in order to further characterize the spectral properties of the two kinds of hematite. For this reason we have analyzed a sample of submicron hematite particles in the 6.25–50 μm range in order to study the influence of particles size and shape on the infrared spectra. The optical constants of a particulate sample have been derived and compared with published data concerning bulk samples of hematite. Our results seem to indicate that particle shape is an important factor to take into account for optical constants derivation.

Streptomycetes are exploited for the production of a wide range of secondary metabolites, including antibiotics. Therefore, both academic and industrial research efforts are focused on enhancing production of these precious metabolites. So far, this has been mostly achieved by classical or recombinant genetic techniques, in association with process optimization for either submerged or solid state fermentation. New cultivation approaches addressing the natural mycelial growth and life cycle would allow the biosynthetic potential of filamentous strains to be much better exploited. We developed a cultivation system for antibiotic-producing microorganisms which involves electrospun organic nanofibers deposited onto agar plates or immersed in liquid media. Dense filamentous networks of branched hyphae formed by bacterial colonies were found to wrapped around the fibers. We analyzed the effects of fibers on growth and antibiotic production in Streptomyces lividans, and found that the actinorhodin, undecylprodigiosin and calcium dependent antibiotic productions were positively modulated, with a two- to sixfold enhancement compared to standard culture conditions. Highlighting the secondary metabolism-promoting role of nanofibers in bacterial cultures, these results open a route to the design of improved culture systems for microorganisms based on organic nanostructures.

Various indications seem to suggest that in the past the Martian climate allowed the presence of liquid water on the surface of the planet. It is therefore reasonable to think that bodies of standing water were once present in basins such as craters or depressions and that evaporite deposits of sulfates could have formed in these basins. The identification of such deposits, which might have survived in some regions of the planet, could confirm the present hypothesis about the ancient climate on Mars. Recent analyses of Mars spectra, obtained by ground-based observations, show bands consistent with sulfate features. If such data have to be interpreted with the aid of synthetic spectra, the knowledge of the complex refractive index of some sulfate is necessary. In this work we present the optical constants of submicron particles of gypsum (a typical hydrate–sulfate very common on Earth), derived by means of the dispersion theory from transmission spectra. We have performed the calculation of the optical constants in the wavelength range 2–70 μm, also in view of the wide spectral range covered by the Planetary Fourier Spectrometer (PFS) on board of the ESA space mission Mars Express. The data have been compared with optical constants obtained by other authors from reflectance measurements of particulate samples.