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59. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): Randomised placebo-controlled trial

Author

Olldashi, F., Muzha, I., Filipi, N., Lede, R., Copertari, P., Traverso, C., Copertari, A., Vergara, E. A., Montenegro, C., De Huidobro, R. R., Surt, K., Cialzeta, J., Lazzeri, S., Pinero, G., Ciccioli, F., Videtta, W., Barboza, M. F., Svampa, S., Sciuto, V., Domeniconi, G., Bustamante, M., Waschbusch, M., Gullo, M. P., Drago, D. A., Linares, J. C. A., Camputaro, L., Troccoli, G., Galimberti, H., Tallott, M., Eybner, C., Buchinger, W., Fitzal, S., Mazairac, G., Oleffe, V., Grollinger, T., Delvaux, P., Carlier, L., Braet, V., Jacques, J. -M., De Knoop, D., Nasi, L., Choi, H. K., Schmitt, M., Gentil, A., Nacul, F., Barrios, P. B., Xinkang, C., Hua, L. S., Tian, H. H., Xiaodong, C., Gualteros, W., Otero, A. A., Arango, M., Ciro, J., Jaramillo, H., Garcia, G., Gonzalez, I., Gomez, C., Arias, A., Fonseca, M., Mora, C., Cabrera, E. G. L., Betancurth, J. L., Munoz, P., Quinonez, J. A., Castillo, M. E. G., Lopez, O., Yepes, R. P., Cuellar, D. L., Paez, G., Chaves, H. D., Ordonez, P. E., Plata, Riccardo, Pineda, M., Pulido, L. E., Jaramillo, J. S. V., Rebolledo, C., Palma, O., Soler, C., Pastrana, I., Falero, R., Perera, M. D., Garcia, A. A., Oliva, R., Delgado, H. L., Carnero, A. M., Lopez, B. L., Gallardo, A. L., Morales, A. O., Lezcano, H., Ferrer, M. I., Bess, I. Z., Canino, G. R., Ruiz, E. M. P., Cruz, O. G., Svoboda, P., Kantorova, I., Ochmann, J., Scheer, P., Kozumplik, L., Marsova, J., Edelmann, K., Chytra, I., Bosman, R., Andrejsova, H., Pachl, J., Burger, J., Kramar, F., Ulloa, M. I., Gonzalez, L., Daccach, A., Ortega, A., Cevallos, S., Cueva, B. Z., Ochoa, M., Tapia, J. V., Hurtado, J., Wong, M. C. S., Santos, R., Khamis, H., Abaza, A. H., Fekry, A., El Kordy, S., Shawky, T., El-Sayed, H., Khalil, N., Negm, N., Fisal, S., Shokry, H., Alamin, M., Elhusseny, A. Y., Radwan, A., Rashid, M., Gogichaisvili, T., Ingorokva, G., Gongadze, N., Otarashvili, A., Kleist, W., Kalkum, M., Ulrich, P., Andrews, N., Nakos, G., Karavelis, A., Archontakis, G., Myrianthefs, P., Yadav, Y., Yadav, S., Khatri, R., Baghel, A., Husain, M., Jha, D., Hoong Chhang, W., Dhandhania, M., Fonning, C., Iyengar, S. N., Gupta, S., Ravi, R. R., Bopiah, K. S., Herur, A., Venkataramana, N. K., Satish, A., Bhavadasan, K., Morris, R., Ramesh, S., Dewan, Y., Singh, Y., Bhagchandani, R., Bhagchandani, S., Sethurayar, V., Ipe, S., Sreekumar, G., Panigrahi, M., Reddy, A., Khosla, V., Pillay, H., Thomas, N., Sridhar, K., Jose, B., Kurian, N., Praharaj, S., Pillai, S., Ramana, Kiyawat, D., Maheshwari, K., Panikar, D., Chawla, J., Shenoy, S., Raja, A., Rupayana, Y., Reddy, S., Mohan, N., Kelkar, S., Johri, M., Golden, N., Maliawan, S., Fauzi, A., Farouk, U., Fakharian, E., Aramesh, A., Eghtedari, M., Ahmadzadeh, F., Gholami, A., Plunkett, P., Redican, C., Mcmahon, G., Annetta, Maria Giuseppina, Mouchaty, H., Bruzzone, E., Harding, B., Qureshi, M., Idris, Z., Abdullah, J., Ghazali, G., Ghani, A., Cheah, F., Gonzalez, J., Loria-Castellanos, J., Jackson, S., Hutchinson, R., Komolafe, E., Adeolu, A., Komolafe, M., Adeyemi-Doro, O., Bankole, F., Shehu, B., Danlami, V., Odebode, O., Oluwadiya, K., Sanni, A., Giebel, H., Kumar, S., Jooma, R., Mezquita, J., Ortiz Ovelar, C., Gonzales-Portillo, M., Rodriguez, D., Balica, L., Oprita, B., Sklerniacof, M., Steflea, L., Bandut, L., Danil, A., Iliescu, R., Ciurea, J., El-Dawlatly, A., Alwatidy, S., Al-Yafi, W., El-Dawlatly, M., Krunic-Protic, R., Janosevic, V., Tan, J., Seah, C., Trenkler, S., Humenansky, M., Stajancova, T., Schwendt, I., Laincz, A., Julius, Z., Maros, S., Firment, J., Cifranicova, M., Saniova, B., Kalig, K., Medekova, S., Wiszt, R., Macsuga, I., Hartzenberg, B., Du Plessis, G., Houlie, Z., Nathoo, N., Khumalo, S., Tracey, R., Munoz-Sanchez, A., Murillo-Cabezas, F., Flores-Cordero, J., Rincon-Ferrari, D., Rubi, M., Caler, L., Del Campo, M., Laguna, L., Manuel Nava, J., Minguillon, M., Lopez, A., Ramos-Gomez, L., De La Torre-Prados, V., Pellejero, R., Laloe, V., Mandrella, B., Suganthan, Perera, S., Mahendran, K., Stocker, R., Ludwig, S., Zimmermann, H., Denzler, U., Yutthakasemsunt, S., Kittiwattanagul, W., Watanachai, C., Subsompon, P., Pussanakawatin, W., Khunjan, P., Tangchitvittaya, S., Nilapong, S., Klangsang, T., Taechakosol, W., Srinat, A., Jerbi, Z., Borsali-Falfoul, N., Rezgui, M., Cakar, N., Ssenyonjo, H., Kobusingye, O., Lomas, G., Yates, D., Lecky, F., Bleetman, A., Baldwin, A., Jenkinson, E., Pantrini, S., Stewart, J., Contractor, N., Roberts, T., Butler, J., Pinto, A., Lee, D., Brayley, N., Robbshaw, K., Dix, C., Graham, S., Pye, S., Green, M., Kellins, A., Moulton, C., Fogg, B., Cottingham, R., Funnell, S., Shanker, U., Summers, C., Malek, L., Ashcroft, C., Powell, J., Moore, S., Buckley, S., Grocutt, M., Chambers, S., Morrice, A., Marshall, H., Harris, J., Matthews, W., Tippet, J., Mardell, S., Macmillan, F., Shaw, A., Luthra, P., Dixon, G., Ahmed, M., Young, M., Mason, S., Loveday, I., Clark, C., Taylor, S., Wilson, P., Ali, K., Greenwood, S., White, M., Perez, R., Eljamel, S., Wasserberg, J., Shale, H., Read, C., Mccarron, J., Pennell, A., Ray, G., Thurston, J., Brown, E., Jaffey, L., Graves, M., Bailey, R., Loveridge, N., Evans, G., Hughes, S., Richardson, J., Gallagher, C., Odedun, T., Lees, K., Foley, D., Payne, N., Pennycook, A., Griffiths, C., Moore, D., Byrne, D., Dasan, S., Banerjee, Abhishek, Mcguinness, S., Chikhani, C., Zoltie, N., Barlow, I., Stell, I., Hulse, W., Crossley, J., Watkins, L., Dorani, B., Vanviet, T., Saladino, P., Cabrera, A., Baigent, C., Bracken, M., Chadwick, D., Curley, K., Duley, L., Farrell, B., Haegi, M., Nickson, G., Peto, R., Pickard, J., Roberts, I., Sandercock, P., Teasdale, G., Collins, R., Haines, S., Macmahon, S., Warlow, C., Edwards, P., Ritchie, N., Shakur, H., Ramos, M., Barnetson, L., Fernandes, J., Tooth, D., Free, C., Narayanan, L., Collander, J., Abernethy, J., Bardswell, J., Mashru, R., Godward, C., Afolabi, L., Ritchie, A., Hosford, T., Collingwood, A., Massey, S., Plata R., Annetta M. (ORCID:0000-0001-7574-1311), Banerjee A., Olldashi, F., Muzha, I., Filipi, N., Lede, R., Copertari, P., Traverso, C., Copertari, A., Vergara, E. A., Montenegro, C., De Huidobro, R. R., Surt, K., Cialzeta, J., Lazzeri, S., Pinero, G., Ciccioli, F., Videtta, W., Barboza, M. F., Svampa, S., Sciuto, V., Domeniconi, G., Bustamante, M., Waschbusch, M., Gullo, M. P., Drago, D. A., Linares, J. C. A., Camputaro, L., Troccoli, G., Galimberti, H., Tallott, M., Eybner, C., Buchinger, W., Fitzal, S., Mazairac, G., Oleffe, V., Grollinger, T., Delvaux, P., Carlier, L., Braet, V., Jacques, J. -M., De Knoop, D., Nasi, L., Choi, H. K., Schmitt, M., Gentil, A., Nacul, F., Barrios, P. B., Xinkang, C., Hua, L. S., Tian, H. H., Xiaodong, C., Gualteros, W., Otero, A. A., Arango, M., Ciro, J., Jaramillo, H., Garcia, G., Gonzalez, I., Gomez, C., Arias, A., Fonseca, M., Mora, C., Cabrera, E. G. L., Betancurth, J. L., Munoz, P., Quinonez, J. A., Castillo, M. E. G., Lopez, O., Yepes, R. P., Cuellar, D. L., Paez, G., Chaves, H. D., Ordonez, P. E., Plata, Riccardo, Pineda, M., Pulido, L. E., Jaramillo, J. S. V., Rebolledo, C., Palma, O., Soler, C., Pastrana, I., Falero, R., Perera, M. D., Garcia, A. A., Oliva, R., Delgado, H. L., Carnero, A. M., Lopez, B. L., Gallardo, A. L., Morales, A. O., Lezcano, H., Ferrer, M. I., Bess, I. Z., Canino, G. R., Ruiz, E. M. P., Cruz, O. G., Svoboda, P., Kantorova, I., Ochmann, J., Scheer, P., Kozumplik, L., Marsova, J., Edelmann, K., Chytra, I., Bosman, R., Andrejsova, H., Pachl, J., Burger, J., Kramar, F., Ulloa, M. I., Gonzalez, L., Daccach, A., Ortega, A., Cevallos, S., Cueva, B. Z., Ochoa, M., Tapia, J. V., Hurtado, J., Wong, M. C. S., Santos, R., Khamis, H., Abaza, A. H., Fekry, A., El Kordy, S., Shawky, T., El-Sayed, H., Khalil, N., Negm, N., Fisal, S., Shokry, H., Alamin, M., Elhusseny, A. Y., Radwan, A., Rashid, M., Gogichaisvili, T., Ingorokva, G., Gongadze, N., Otarashvili, A., Kleist, W., Kalkum, M., Ulrich, P., Andrews, N., Nakos, G., Karavelis, A., Archontakis, G., Myrianthefs, P., Yadav, Y., Yadav, S., Khatri, R., Baghel, A., Husain, M., Jha, D., Hoong Chhang, W., Dhandhania, M., Fonning, C., Iyengar, S. N., Gupta, S., Ravi, R. R., Bopiah, K. S., Herur, A., Venkataramana, N. K., Satish, A., Bhavadasan, K., Morris, R., Ramesh, S., Dewan, Y., Singh, Y., Bhagchandani, R., Bhagchandani, S., Sethurayar, V., Ipe, S., Sreekumar, G., Panigrahi, M., Reddy, A., Khosla, V., Pillay, H., Thomas, N., Sridhar, K., Jose, B., Kurian, N., Praharaj, S., Pillai, S., Ramana, Kiyawat, D., Maheshwari, K., Panikar, D., Chawla, J., Shenoy, S., Raja, A., Rupayana, Y., Reddy, S., Mohan, N., Kelkar, S., Johri, M., Golden, N., Maliawan, S., Fauzi, A., Farouk, U., Fakharian, E., Aramesh, A., Eghtedari, M., Ahmadzadeh, F., Gholami, A., Plunkett, P., Redican, C., Mcmahon, G., Annetta, Maria Giuseppina, Mouchaty, H., Bruzzone, E., Harding, B., Qureshi, M., Idris, Z., Abdullah, J., Ghazali, G., Ghani, A., Cheah, F., Gonzalez, J., Loria-Castellanos, J., Jackson, S., Hutchinson, R., Komolafe, E., Adeolu, A., Komolafe, M., Adeyemi-Doro, O., Bankole, F., Shehu, B., Danlami, V., Odebode, O., Oluwadiya, K., Sanni, A., Giebel, H., Kumar, S., Jooma, R., Mezquita, J., Ortiz Ovelar, C., Gonzales-Portillo, M., Rodriguez, D., Balica, L., Oprita, B., Sklerniacof, M., Steflea, L., Bandut, L., Danil, A., Iliescu, R., Ciurea, J., El-Dawlatly, A., Alwatidy, S., Al-Yafi, W., El-Dawlatly, M., Krunic-Protic, R., Janosevic, V., Tan, J., Seah, C., Trenkler, S., Humenansky, M., Stajancova, T., Schwendt, I., Laincz, A., Julius, Z., Maros, S., Firment, J., Cifranicova, M., Saniova, B., Kalig, K., Medekova, S., Wiszt, R., Macsuga, I., Hartzenberg, B., Du Plessis, G., Houlie, Z., Nathoo, N., Khumalo, S., Tracey, R., Munoz-Sanchez, A., Murillo-Cabezas, F., Flores-Cordero, J., Rincon-Ferrari, D., Rubi, M., Caler, L., Del Campo, M., Laguna, L., Manuel Nava, J., Minguillon, M., Lopez, A., Ramos-Gomez, L., De La Torre-Prados, V., Pellejero, R., Laloe, V., Mandrella, B., Suganthan, Perera, S., Mahendran, K., Stocker, R., Ludwig, S., Zimmermann, H., Denzler, U., Yutthakasemsunt, S., Kittiwattanagul, W., Watanachai, C., Subsompon, P., Pussanakawatin, W., Khunjan, P., Tangchitvittaya, S., Nilapong, S., Klangsang, T., Taechakosol, W., Srinat, A., Jerbi, Z., Borsali-Falfoul, N., Rezgui, M., Cakar, N., Ssenyonjo, H., Kobusingye, O., Lomas, G., Yates, D., Lecky, F., Bleetman, A., Baldwin, A., Jenkinson, E., Pantrini, S., Stewart, J., Contractor, N., Roberts, T., Butler, J., Pinto, A., Lee, D., Brayley, N., Robbshaw, K., Dix, C., Graham, S., Pye, S., Green, M., Kellins, A., Moulton, C., Fogg, B., Cottingham, R., Funnell, S., Shanker, U., Summers, C., Malek, L., Ashcroft, C., Powell, J., Moore, S., Buckley, S., Grocutt, M., Chambers, S., Morrice, A., Marshall, H., Harris, J., Matthews, W., Tippet, J., Mardell, S., Macmillan, F., Shaw, A., Luthra, P., Dixon, G., Ahmed, M., Young, M., Mason, S., Loveday, I., Clark, C., Taylor, S., Wilson, P., Ali, K., Greenwood, S., White, M., Perez, R., Eljamel, S., Wasserberg, J., Shale, H., Read, C., Mccarron, J., Pennell, A., Ray, G., Thurston, J., Brown, E., Jaffey, L., Graves, M., Bailey, R., Loveridge, N., Evans, G., Hughes, S., Richardson, J., Gallagher, C., Odedun, T., Lees, K., Foley, D., Payne, N., Pennycook, A., Griffiths, C., Moore, D., Byrne, D., Dasan, S., Banerjee, Abhishek, Mcguinness, S., Chikhani, C., Zoltie, N., Barlow, I., Stell, I., Hulse, W., Crossley, J., Watkins, L., Dorani, B., Vanviet, T., Saladino, P., Cabrera, A., Baigent, C., Bracken, M., Chadwick, D., Curley, K., Duley, L., Farrell, B., Haegi, M., Nickson, G., Peto, R., Pickard, J., Roberts, I., Sandercock, P., Teasdale, G., Collins, R., Haines, S., Macmahon, S., Warlow, C., Edwards, P., Ritchie, N., Shakur, H., Ramos, M., Barnetson, L., Fernandes, J., Tooth, D., Free, C., Narayanan, L., Collander, J., Abernethy, J., Bardswell, J., Mashru, R., Godward, C., Afolabi, L., Ritchie, A., Hosford, T., Collingwood, A., Massey, S., Plata R., Annetta M. (ORCID:0000-0001-7574-1311), and Banerjee A.

Abstract

Background Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, findings of a systematic review suggested that these drugs reduce risk of death by 1-2%. The CRASH trial—a multicentre international collaboration—aimed to confirm or refute such an effect by recruiting 20 000 patients. In May, 2004, the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment. Methods 10 008 adults with head injury and a Glasgow coma score (GCS) of 14 or less within 8 h of injury were randomly allocated 48 h infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury and death or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury to randomisation. Analysis was by intention to treat. Effects on outcomes within 2 weeks of randomisation are presented in this report. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN74459797. Findings Compared with placebo, the risk of death from all causes within 2 weeks was higher in the group allocated corticosteroids (1052 [21·1%] vs 893 [17·9%] deaths; relative risk 1·18 [95% CI 1·09-1·27]; p=0·0001). The relative increase in deaths due to corticosteroids did not differ by injury severity (p=0·22) or time since injury (p=0·05). Interpretation Our results show there is no reduction in mortality with methylprednisolone in the 2 weeks after head injury. The cause of the rise in risk of death within 2 weeks is unclear.

Published
2004

62. Update on progress in the international, multicenter, randomized, controlled trial of corticosteroids after significant head injury (Medical Research Council CRASH Trial)

Author

Lede, R., Hickling, K., Mazairac, G., Nasi, L. A., Xinkang, C., Arango, M. F., Rodriguez, O. P., Soler, C., Svoboda, P., El-Sayed, H., Khamis, H., Plunkett, P., Gaab, M. R., Nakos, G., Annetta, Maria Giuseppina, Abdullah, J., Idris, Z., Jackson, S., Adeyemi-Doro, H. O., Batica, L., Oprita, B., Tan, J. S. H., Trenkler, S., Hartzenberg, B., Munoz Sanchez, M. D. L. A., Laloe, V., Mandrella, B., Ludwig, S., Jerbi, Z., Cakar, N., Kobusingye, O., Massey, S., Fernandes, J., Mashru, R., Annetta M. G. (ORCID:0000-0001-7574-1311), Lede, R., Hickling, K., Mazairac, G., Nasi, L. A., Xinkang, C., Arango, M. F., Rodriguez, O. P., Soler, C., Svoboda, P., El-Sayed, H., Khamis, H., Plunkett, P., Gaab, M. R., Nakos, G., Annetta, Maria Giuseppina, Abdullah, J., Idris, Z., Jackson, S., Adeyemi-Doro, H. O., Batica, L., Oprita, B., Tan, J. S. H., Trenkler, S., Hartzenberg, B., Munoz Sanchez, M. D. L. A., Laloe, V., Mandrella, B., Ludwig, S., Jerbi, Z., Cakar, N., Kobusingye, O., Massey, S., Fernandes, J., Mashru, R., and Annetta M. G. (ORCID:0000-0001-7574-1311)

Abstract

Purpose of review: To provide an update on the progress of the multicenter, randomized, controlled trial of corticosteroids after significant head injury (CRASH). Recent findings: After a successful pilot phase, the main phase of the CRASH Trial began in March 2001. By June 2002, 107 hospitals from 31 countries were participating in the trial, and together had recruited 3000 patients. Nine hundred patients (30%) had mild head injury, 885 (30%) had moderate head injury, and 1215 (40%) had severe head injury. A total of 1941 (65%) patients were randomized within 3 hours of injury. Outcome at 2 weeks from injury was known for 2933 (98%) patients, of whom 557 (19%) died. At the time of writing, 6-month follow-up for the first 1500 patients was nearly complete. Vital status was known for 1429 (95%) of the 1500 patients, of whom 313 (22%) had died. Functional status based on the Glasgow Outcome Scale was known for 1391 (93%) of the 1500 patients: 22% were dead, 16% were severely disabled, 23% were moderately disabled, and 39% had made a good recovery. Summary: The CRASH Trial is a randomized, placebo-controlled, multicenter trial of a 48-hour corticosteroid infusion after significant head injury and is now the largest head injury trial ever conducted. The efforts of the national coordinators have shown that it is possible to enroll and follow up very large numbers of head-injured patients.

Published
2003

63. A Connectionism Approach to the Emulation of Multi-Agent Mobile Robots

Author

Massey, S. and Zalzala, A.M.S.

Abstract

The work presented in this report deals with the modelling and subsequent neural network emulation of autonomous mobile robots, moving in pre-defined environments in response to given control signals. This work was undertaken with the intention of training neural network based controllers for the vehicles, in order to control them whilst they performed required navigational tasks, whilst avoiding collisions with each other and with environmental obstacles. The required modelling was carried out using a combination of trigonometry and geometry, the corresponding neural network emulators were trained using an algorithm based on back propagation and the resulting emulator networks performed well enough for work to now begin on controller training.

Published
1994

64. Angiogenesis and Invasion

Author

Fishman, R. A., primary, Happ, E., additional, Stevens, T., additional, Kunschner, L., additional, Jaworski, D. M., additional, Stradecki, H. M., additional, Penar, P. L., additional, Pendlebury, W. W., additional, Pennington, C. J., additional, Edwards, D. R., additional, Broaddus, W. C., additional, Fillmore, H. L., additional, Mukherjee, J., additional, Hawkins, C., additional, Guha, A., additional, Pioli, P. D., additional, Milani, S., additional, Linskey, M. E., additional, Zhou, Y.-H., additional, Marchetti, V., additional, Barnett, F., additional, Wang, M., additional, Scheppke, L., additional, Sanchez-Cespedes, J., additional, De Rossi, C., additional, Nemerow, G., additional, Torbett, B., additional, Friedlander, M., additional, Goldlust, S. A., additional, Singer, S., additional, DeAngelis, L. M., additional, Lassman, A. B., additional, Nolan, C. P., additional, Yang, S.-H., additional, Lee, S. W., additional, Chen, Z.-p., additional, Liu, X.-m., additional, Wojton, J. A., additional, Chu, Z., additional, Qi, X., additional, Kaur, B., additional, Hu, Y., additional, Siegel, E., additional, Ro, D. I., additional, Marlon, S., additional, Hsu, N., additional, Milani, S. N., additional, Mohan, S., additional, Yu, L., additional, Hess, K. R., additional, Liu, Y., additional, Carson-Walter, E., additional, Walter, K., additional, Raghu, H., additional, Gondi, C. S., additional, Gujrati, M., additional, Dinh, D. H., additional, Rao, J. S., additional, Narayana, A., additional, Kunnakkat, S. D., additional, Medabalmi, P., additional, Golfinos, J., additional, Parker, E., additional, Knopp, E., additional, Zagzag, D., additional, Gruber, D., additional, Gruber, M. L., additional, Burrell, K., additional, Jelveh, S., additional, Lindsey, P., additional, Hill, R., additional, Zadeh, G., additional, Ivkovic, S., additional, Beadle, C., additional, Massey, S. C., additional, Swanson, K. R., additional, Canoll, P., additional, Rosenfeld, S. S., additional, McAllister, S., additional, Soroceanu, L., additional, Pakdel, A., additional, Limbad, C., additional, Adrados, I., additional, Desprez, P.-Y., additional, Nakada, M., additional, Nambu, E., additional, Furuyama, N., additional, Yoshida, Y., additional, Kita, D., additional, Hayashi, Y., additional, Hamada, J.-i., additional, Seyed Sadr, M., additional, Maret, D., additional, Seyed Sadr, E., additional, Siu, V., additional, Alshami, J., additional, Denault, J.-S., additional, Faury, D., additional, Jabado, N., additional, Nantel, A., additional, Del Maestro, R., additional, Perretta, D., additional, Nagaiah, G., additional, Almubarak, M., additional, Torres-Trejo, A., additional, Newton,, M., additional, Willey, P., additional, Altaha, R., additional, Murphy, S. F., additional, Banasiak, M., additional, Yee, G.-T., additional, Wotoczek-Obadia, M., additional, Tran, Y., additional, Prak, A., additional, Albright, R., additional, Mullan, M., additional, Paris, D., additional, Brem, S., additional, Yang, Y.-P., additional, Ennis, M., additional, Tran, N., additional, Symons, M., additional, Najbauer, J., additional, Huszthy, P. C., additional, Garcia, E., additional, Metz, M. Z., additional, Gutova, M., additional, Frank, R. T., additional, Miletic, H., additional, Glackin, C. A., additional, Barish, M. E., additional, Bjerkvig, R., additional, Aboody, K. S., additional, Clump, D. A., additional, Engh, J. A., additional, Mintz, A. H., additional, Cunnick, J., additional, Flynn, D. C., additional, Clark, A. J., additional, Butowski, N. A., additional, Chang, S. M., additional, Prados, M. D., additional, Clarke, J., additional, Polley, M.-Y. C., additional, Sughrue, M. E., additional, McDermott, M. W., additional, Parsa, A. T., additional, Berger, M. S., additional, Aghi, M. K., additional, Megyesi, J. F., additional, Costello, P., additional, Macdonald, W., additional, Dyer, E., additional, Macdonald, D., additional, Hammond, R., additional, Kalache, Y., additional, Easaw, J., additional, McIntyre, J., additional, Williams, S. C., additional, Karajannis, M. A., additional, Chiriboga, L., additional, von Deimling, A., additional, Ajlan, A., additional, Husaine, S., additional, Petrecca, K., additional, Magnus, N., additional, Garnier, D., additional, Meehan, B., additional, and Rak, J., additional

Published
2010
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65. Cell Biology and Signaling

Author

Long, P. M., primary, Wesley, U. V., additional, Jaworski, D. M., additional, Rana, M., additional, Kiehl, T.-R., additional, So, K., additional, Gould, P., additional, Ajewung, N., additional, Kamnasaran, D., additional, Emmett, M. R., additional, Wang, X., additional, Marshall, A. G., additional, Ji, Y., additional, Fokt, I., additional, Skora, S., additional, Conrad, C. A., additional, Priebe, W., additional, Zhu, H., additional, Cao, X., additional, Keir, S., additional, Ali-Osman, F., additional, Lo, H.-W., additional, Da Fonseca, C. O., additional, Arun, V., additional, Wiley, J. C., additional, Kaur, H., additional, Guha, A., additional, Fenton, K., additional, Abdelwahab, M. G., additional, Stafford, P., additional, Rho, J. M., additional, Preul, M. C., additional, Scheck, A. C., additional, Brossier, N. M., additional, Carroll, S. L., additional, Gajadhar, A., additional, Mukherjee, J., additional, Wolf, A., additional, Hawkins, C., additional, Costa, P., additional, Cardoso, A. L. C., additional, de Almeida, L. P., additional, de Lima, M. C. P., additional, Canoll, P., additional, Bruce, J., additional, Lavon, I., additional, Granit, A., additional, Einstein, O., additional, Ben-Hur, T., additional, Siegal, T., additional, Pang, J. C., additional, Poon, W. S., additional, Zhou, L., additional, Ng, H.-K., additional, Rovin, R. A., additional, Lawrence, J. E., additional, Segula, J. J., additional, Winn, R. J., additional, Patil, S., additional, Burzynski, S. R., additional, Mrowczynski, E., additional, Grela, K., additional, Cheng, S., additional, Liu, K., additional, Feng, H., additional, Bacho, R., additional, Kazlauskas, A., additional, Smith, E. M., additional, Symes, K., additional, Hu, B., additional, Lee, C. Y., additional, Fotovati, A., additional, Dunn, S. E., additional, Proescholdt, M. A., additional, Storr, E.-M., additional, Lohmeier, A., additional, Brawanski, A., additional, Jarzynka, M. J., additional, Ravichandran, K. S., additional, Vuori, K., additional, Tang, C., additional, Nshikawa, R., additional, Johns, T. G., additional, Furnari, F. B., additional, Cavenee, W. K., additional, Zhong, J., additional, O'Neill, G. M., additional, Deleyrolle, L. P., additional, Rahman, M., additional, Dunbar, E. M., additional, Caldeira, M. A., additional, Reynolds, B. A., additional, Liu, X., additional, Yacyshyn, S., additional, Dasgupta, B., additional, Han, X., additional, Yang, X., additional, Wheeler, C. G., additional, Filippova, N., additional, Langford, C. P., additional, Ding, Q., additional, Fathallah, H. M., additional, Gillespie, G. Y., additional, Nabors, L. B., additional, Davidson, T. B., additional, Gortalum, F., additional, Ji, L., additional, Engell, K., additional, Sposto, R., additional, Asgharzadeh, S., additional, Erdreich-Epstein, A., additional, Lawn, S. O., additional, Weiss, S., additional, Senger, D., additional, Forsyth, P., additional, Latha, K., additional, Chumbalkar, V., additional, Li, M., additional, Gururaj, A., additional, Hwang, Y., additional, Maywald, R., additional, Dakeng, S., additional, Dao, L., additional, Baggerly, K., additional, Sawaya, R., additional, Aldape, K., additional, Cavenee, W., additional, Furnari, F., additional, Bogler, O., additional, Arumugam, J., additional, Sim, H., additional, Pineda, C. A., additional, Pan, Y., additional, Viapiano, M. S., additional, Van Schaick, J. A., additional, Akagi, K., additional, Burkett, S., additional, DiFabio, C., additional, Tuskan, R., additional, Walrath, J., additional, Reilly, K., additional, Dai, B., additional, Jing, Z., additional, Kang, S.-H., additional, Li, D., additional, Xie, K., additional, Huang, S., additional, Gong, X., additional, Vuong, Y., additional, Bota, D. A., additional, Stegh, A. H., additional, Inda, M.-d.-M., additional, Bonavia, R., additional, Mukasa, A., additional, Narita, Y., additional, Sah, D., additional, Vandenberg, S., additional, Brennan, C., additional, Johns, T., additional, Bachoo, R., additional, Hadwiger, P., additional, Tan, P., additional, DePinho, R., additional, Kusne, Y., additional, Meerson, A., additional, Rushing, E. J., additional, Yang, W., additional, McDonough, W., additional, Kislin, K., additional, Loftus, J. C., additional, Berens, M., additional, Lu, Z., additional, Ghosh, S., additional, Verma, A., additional, Zhou, H., additional, Chin, S., additional, Bruggers, C., additional, Kestle, J., additional, Khatua, S., additional, Broekman, M. L., additional, Maas, N. S., additional, Skog, J., additional, Breakefield, X. O., additional, Sena-Esteves, M., additional, de Vrij, J., additional, Lamfers, M., additional, Maas, N., additional, Dirven, C., additional, Esteves, M., additional, Broekman, M., additional, Chidambaram, A., additional, Dumur, C. I., additional, Graf, M., additional, Vanmeter, T. E., additional, Fillmore, H. L., additional, Broaddus, W. C., additional, Silber, J., additional, Ozawa, T., additional, Kastenhuber, E., additional, Djaballah, H., additional, Holland, E. C., additional, Huse, J. T., additional, Agnihotri, S., additional, Munoz, D., additional, Han, J. E., additional, Albesiano, E., additional, Pradilla, G., additional, Lim, M., additional, Alshami, J., additional, Sabau, C., additional, Seyed Sadr, M., additional, Anan, M., additional, Seyed Sadr, E., additional, Siu, V., additional, Del Maestro, R., additional, Trinh, G., additional, Le, P., additional, Petrecca, K., additional, Sonabend, A. M., additional, Soderquist, C., additional, Lei, L., additional, Guarnieri, P., additional, Leung, R., additional, Yun, J., additional, Sisti, J., additional, Castelli, M., additional, Bruce, S., additional, Bruce, R., additional, Ludwig, T., additional, Rosenfeld, S., additional, Bruce, J. N., additional, Phillips, J. J., additional, Huillard, E., additional, Polley, M.-Y., additional, Rosen, S. D., additional, Rowitch, D. H., additional, Werb, Z., additional, Sarkar, C., additional, Jha, P., additional, Pathak, P., additional, Suri, V., additional, Sharma, M. C., additional, Chattopadhyay, P., additional, Chosdol, K., additional, Suri, A., additional, Gupta, D., additional, Mahapatra, A. K., additional, Kapoor, G. S., additional, Zhan, Y., additional, Boockvar, J. A., additional, O'Rourke, D. M., additional, Kwatra, M. M., additional, Kim, J. W., additional, Park, C.-K., additional, Han, J. H., additional, Park, S. H., additional, Kim, S.-K., additional, Jung, H.-W., additional, Narayanan, R., additional, Levin, B. S., additional, Maeder, M. L., additional, Joung, J. K., additional, Nutt, C. L., additional, Louis, D. N., additional, Dudley, A., additional, Jayaram, P., additional, Pei, Z., additional, Shi, X., additional, Laterra, J., additional, Watkins, P. A., additional, Mawrin, C., additional, Rempel, S. A., additional, McClung, H. M., additional, McFarland, B. C., additional, Nozell, S. E., additional, Huszar, D., additional, Benveniste, E. N., additional, Burton, T., additional, Eisenstat, D. D., additional, Gibson, S. B., additional, Lukiw, W. J., additional, Cui, J. G., additional, Li, Y. Y., additional, Zhao, Y., additional, Culicchia, F., additional, See, W., additional, Pieper, R., additional, Luchman, A., additional, Stechishin, O., additional, Nguyen, S., additional, Kelly, J., additional, Blough, M., additional, Cairncross, G., additional, Shah, S. R., additional, Mohyeldin, A., additional, Adams, H., additional, Garzon-Muvdi, T., additional, Aprhys, C., additional, Quinones-Hinojosa, A., additional, Weeks, A. C., additional, Restrepo, A., additional, Ivanchuk, S., additional, Smith, C., additional, Rutka, J. T., additional, Sengupta, R., additional, Yang, L., additional, Burbassi, S., additional, Zhang, B., additional, Markant, S. L., additional, Yang, Z.-j., additional, Meucci, O., additional, Wechsler-Reya, R. J., additional, Rubin, J. B., additional, Wykosky, J., additional, Chin, L., additional, Auvergne, R. M., additional, Sim, F. J., additional, Wang, S., additional, Chandler-Militello, D., additional, Burch, J., additional, Li, X., additional, Bennet, A., additional, Mohile, N., additional, Pilcher, W., additional, Walter, K., additional, Johnson, M., additional, Achanta, P., additional, Natesan, S., additional, Goldman, S. A., additional, Beauchamp, A. S., additional, Gibo, D. M., additional, Debinski, W., additional, Jiang, H., additional, Martin, V., additional, Gomez-Manzano, C., additional, Johnson, D. G., additional, Alonso, M., additional, White, E. J., additional, Xu, J., additional, McDonnell, T., additional, Shinojima, N., additional, Fueyo, J., additional, Sandhya Rani, M. R., additional, Huang, P., additional, Prayson, R., additional, Hedayat, H., additional, Sloan, A. E., additional, Novacki, A., additional, Ahluwalia, M. S., additional, Tipps, R., additional, Gladson, C. L., additional, Liu, J.-L., additional, Mao, Z., additional, Yung, W. K. A., additional, Bhat, K., additional, Salazar, K., additional, Balasubramaniyan, V., additional, Vaillant, B., additional, Hollingsworth, F., additional, Gumin, J., additional, Diefes, K., additional, Patel, D., additional, Lang, F., additional, Colman, H., additional, Parsyan, A., additional, Shahbazian, D., additional, Alain, T., additional, Martineau, Y., additional, Petroulakis, E., additional, Larsson, O., additional, Gkogkas, C., additional, Topisirovic, I., additional, Mathonnet, G., additional, Tettweiler, G., additional, Hellen, C., additional, Pestova, T., additional, Svitkin, Y., additional, Sonenberg, N., additional, Zerrouqi, A., additional, Pyrzynska, B., additional, Van Meir, E., additional, Twitty, G. B., additional, Hong, S. W., additional, Lee, H. K., additional, Finniss, S., additional, Xiang, C., additional, Cazacu, S., additional, Brodie, C., additional, Ginn, K. F., additional, Wise, A., additional, Farassati, F., additional, Brown, C., additional, Barish, M., additional, deCarvalho, A. C., additional, Hasselbach, L., additional, Nelson, K., additional, Lemke, N., additional, Schultz, L., additional, Mikkelsen, T., additional, Onvani, S., additional, Kongkham, P., additional, Smith, C. A., additional, Bier, A., additional, Hershkovitz, H., additional, Kahana, S., additional, Decarvalho, A., additional, Massey, S. C., additional, and Swanson, K. R., additional

Published
2010
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68. ChemInform Abstract: Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvul

Author

MONN, J. A., primary, VALLI, M. J., additional, MASSEY, S. M., additional, WRIGHT, R. A., additional, SALHOFF, C. R., additional, JOHNSON, B. G., additional, HOWE, T., additional, ALT, C. A., additional, RHODES, G. A., additional, ROBEY, R. L., additional, GRIFFEY, K. R., additional, TIZZANO, J. P., additional, KALLMAN, M. J., additional, HELTON, D. R., additional, and SCHOEPP, D. D., additional

Published
2010
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92. Das Konservieren von Baudenkmalen: eine neue Methode, um die Wirksamkeit einer stein festigenden Massnahme nachzuweisen / The conservation of monuments: A new method to evaluate consolidating treatments

Author

Tiano, P., primary, Rodrigues, J. Delgado, additional, De Witte, E., additional, Vergès-Belmin, V., additional, Massey, S., additional, Snethlage, R., additional, Costa, D., additional, Cadot-Leroux, L., additional, Garrod, E., additional, and Singer, B., additional

Published
2000
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100. Impact of a single-day multidisciplinary clinic on the management of patients with liver tumours.

Author

J. Zhang, Mavros, M. N., Cosgrove, D., Hirose, K., Herman, J. M., Smallwood-Massey, S., Kamel, I., Gurakar, A., Anders, R., Cameron, A., Geschwind, J. F. H., and Pawlik, T. M.

Subjects
CANCER patients, CANCER treatment, CANCER in women, CANCER chemotherapy, PATHOLOGY, DIAGNOSIS
Abstract

Purpose Multidisciplinary cancer clinics may improve patient care. We examined how a single-day multidisciplinary liver clinic (mdlc) affected care recommendations for patients compared with the recommendations provided before presentation to the mdlc. Methods We analyzed the demographic and clinicopathologic data of 343 patients assessed in the Johns Hopkins Liver Tumor Center from 2009 to 2012, comparing imaging and pathology interpretation, diagnosis, and management plan between the outside provider (osp) and the mdlc. Results Most patients were white (n = 259, 76%); median age was 60 years; and 146 were women (43%). Outside providers referred 182 patients (53%); the rest were self-referred. Patients travelled median of 83.4 miles (interquartile range: 42.7-247 miles). Most had already undergone imaging (n = 338, 99%) and biopsy (n = 194, 57%) at the osp, and a formal management plan had been formulated for about half (n = 168, 49%). Alterations in the interpretation of imaging occurred for 49 patients (18%) and of biopsy for 14 patients (10%). Referral to the mdlc resulted in a change of diagnosis in 26 patients (8%), of management plan in 70 patients (42%), and of tumour resectability in 7 patients (5%). Roughly half the patients (n = 174,51%) returned for a follow-up, and 154 of the returnees (89%) received treatment, primarily intraarterial therapy (n = 88, 57%), systemic chemotherapy (n = 60, 39%), or liver resection (n = 32, 21%). Enrollment in a clinical trial was proposed to 34 patients (10%), and 21 of the 34 (62%) were accrued. Conclusions Patient assessment by our multidisciplinary liver clinic had a significant impact on management, resulting in alterations to imaging and pathology interpretation, diagnosis, and management plan. The mdlc is an effective and convenient means of delivering expert opinion about the diagnosis and management of liver tumours. [ABSTRACT FROM AUTHOR]

Published
2013
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