51. Altered white matter microstructure is related to cognition in adults with congenital heart disease
- Author
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Ruth O'Gorman Tuura, Peter Brugger, Raimund Kottke, Angela Oxenius, Matthias Greutmann, Melanie Ehrler, Ladina Schlosser, Beatrice Latal, University of Zurich, and Latal, Beatrice
- Subjects
cognition ,medicine.medical_specialty ,Heart disease ,2804 Cellular and Molecular Neuroscience ,610 Medicine & health ,030204 cardiovascular system & hematology ,White matter ,03 medical and health sciences ,2738 Psychiatry and Mental Health ,0302 clinical medicine ,Quality of life ,Internal medicine ,Fractional anisotropy ,medicine ,medicine.diagnostic_test ,AcademicSubjects/SCI01870 ,business.industry ,General Engineering ,Neuropsychological test ,diffusion tensor imaging ,medicine.disease ,congenital heart disease ,medicine.anatomical_structure ,executive function ,white matter microstructure ,10036 Medical Clinic ,2808 Neurology ,Corticospinal tract ,Cardiology ,10209 Clinic for Cardiology ,Original Article ,AcademicSubjects/MED00310 ,business ,Neurocognitive ,2803 Biological Psychiatry ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
Adults with congenital heart disease are at risk for persisting executive function deficits, which are known to affect academic achievement and quality of life. Alterations in white -matter microstructure are associated with cognitive impairments in adolescents with congenital heart disease. This study aimed to identify microstructural alterations potentially associated with executive function deficits in adults with congenital heart disease. Diffusion tensor imaging and tract-based spatial statistics were conducted in 45 patients (18 females) and 54 healthy controls (26 females) aged 18–32 years. Fractional anisotropy of white matter diffusion was compared between groups and correlated with an executive function score, derived from an extensive neuropsychological test battery. Patients showed widespread bilateral reduction in fractional anisotropy (P, As more patients with congenital heart disease are surviving into adulthood, interest mounts in the link between congenital heart disease and neurodevelopment across the lifespan. This is the first study in adults with congenital heart disease, demonstrating widespread alterations in white matter microstructure and an association with executive function deficits., Graphical Abstract Graphical Abstract
- Published
- 2021