51. miR-34b/c rs4938723 T>C Decreases Neuroblastoma Risk: A Replication Study in the Hunan Children.
- Author
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Li Y, Zhuo ZJ, Zhou H, Liu J, Xiao Z, Xiao Y, He J, and Liu Z
- Subjects
- Adrenal Gland Neoplasms diagnosis, Adrenal Gland Neoplasms ethnology, Adrenal Gland Neoplasms pathology, Alleles, Asian People, Case-Control Studies, Child, Preschool, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Logistic Models, Male, Mediastinal Neoplasms diagnosis, Mediastinal Neoplasms ethnology, Mediastinal Neoplasms pathology, Mutation, Neuroblastoma diagnosis, Neuroblastoma ethnology, Neuroblastoma pathology, Odds Ratio, Retroperitoneal Neoplasms diagnosis, Retroperitoneal Neoplasms ethnology, Retroperitoneal Neoplasms pathology, Risk, Adrenal Gland Neoplasms genetics, Gene Expression Regulation, Neoplastic, Mediastinal Neoplasms genetics, MicroRNAs genetics, Neuroblastoma genetics, Retroperitoneal Neoplasms genetics
- Abstract
Neuroblastoma is the most common seen solid neural tumor in children less than age one. As mutation in the miR-34b/c gene is observed in several types of human malignancies, there likely to be similar events that contribute to the pathogenesis of neuroblastoma. We hypothesize that polymorphism in the miR-34b/c gene might predispose to neuroblastoma. Here, we conducted this replication study by genotyping rs4938723 T>C from miR-34b/c in Hunan children (162 subjects with neuroblastoma and 270 control subjects) and examined its effect on the risk of neuroblastoma. We determined such association using logistic regression, adjusted for age and gender. Relative to those with TT genotype, subjects with C allele had reduced neuroblastoma risk (TC vs. TT: adjusted OR = 0.46, 95%CI = 0.30-0.71; additive model: adjusted OR = 0.64, 95%CI = 0.47-0.88; TC/CC vs. TT: adjusted OR = 0.49, 95%CI = 0.33-0.73). Stratified analysis revealed that rs4938723 TC/CC carriers were less likely to develop neuroblastoma for patients in the subgroups of age ≤ 18 months, age > 18 months, females, males, tumors in retroperitoneal, tumors in other sites, and clinical stages II, III, IV, and III+IV. Our findings verified miR-34b/c rs4938723 C variant allele as a protective factor for the risk of neuroblastoma. Further investigation of how miR-34b/c rs4938723 T>C might modify neuroblastoma risk is warranted., Competing Interests: The authors declared that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2019 Yong Li et al.)
- Published
- 2019
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