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Many studies suggest that information about past experience, or episodic memory, is divided into discrete units called "events." Yet we can often remember experiences that span multiple events. Events that occur in close succession might simply be linked because of their proximity to one another, but we can also build links between events that occur farther apart in time. Intuitively, some kind of organizing principle should enable temporally distant events to become bridged in memory. We tested the hypothesis that episodic memory exhibits a narrative-level organization, enabling temporally distant events to be better remembered if they form a coherent narrative. Furthermore, we tested whether post-encoding memory consolidation is necessary to integrate temporally distant events. In three experiments, participants learned and subsequently recalled events from fictional stories, in which pairs of temporally distant events involving side characters ("sideplots") either formed one coherent narrative or two unrelated narratives. Across participants, we varied whether recall was assessed immediately after learning, or after a delay: 24 hours, 12 hours between morning and evening ("wake"), or 12 hours between evening and morning ("sleep"). Participants recalled more information about coherent than unrelated narrative events, in most delay conditions, including immediate recall and wake conditions, suggesting that post-encoding consolidation was not necessary to integrate temporally distant events into a larger narrative. Furthermore, post hoc modeling across experiments suggested that narrative coherence facilitated recall over and above any effects of sentence-level semantic similarity. This reliable memory benefit for coherent narrative events supports theoretical accounts which propose that narratives provide a high-level architecture for episodic memory.

ObjectivesTo determine whether music engagement influences middle-aged and older adults' performance on episodic memory tasks.MethodSecondary data analysis of a sample (N = 4,592) of cognitively healthy adults from the 2016 Health and Retirement Study was used for this study. Multivariable regression models were used to analyze the cross-sectional differences in performance on tasks of episodic memory between participants who listened to music (n = 3,659) or sang or played an instrument (n = 989).ResultsOn average, participants recalled 10.3 words out of a possible 20. Regression analyses showed that both listening to music and singing or playing an instrument were independently associated with significantly better episodic memory.DiscussionThe findings provide the first population-based evidence that music engagement is associated with better episodic memory among middle-aged and older adults. Future studies should examine whether the relationship between music engagement and episodic memory can be replicated in other populations and that the association persists in longitudinal studies.

While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe (MTL) during the formation and retrieval of memories with complex narratives. Here, we show that neurons responded to abstract cognitive boundaries between different episodes. Boundary-induced neural state changes during encoding predicted subsequent recognition accuracy but impaired event order memory, mirroring a fundamental behavioral tradeoff between content and time memory. Furthermore, the neural state following boundaries was reinstated during both successful retrieval and false memories. These findings reveal a neuronal substrate for detecting cognitive boundaries that transform experience into mnemonic episodes and structure mental time travel during retrieval.

OBJECTIVE: Existing research has demonstrated that patient memory and learning of treatment contents are poor and poorer learning is associated with worse treatment outcome. Most prior studies have included individuals from only a single diagnostic group, offer limited data on possible contributors to poor memory and learning, and have included small samples recruited in university settings. This study sought to describe patient recall of treatment contents, describe patient learning of treatment contents, examine contributors to patient recall and learning of treatment contents, and examine the association of patient recall and learning of treatment contents with treatment outcome. METHODS: Adults with serious mental illness and sleep and circadian dysfunction (N = 99) received the Transdiagnostic Intervention for Sleep and Circadian Dysfunction in a community mental health setting. Measures of recall, learning, age, years of education, symptom severity, and treatment outcome were collected at post-treatment and 6-month follow-up. RESULTS: Recall and learning were poor, fewer years of education was associated with worse recall and learning, and recall and learning were not associated with treatment outcome. CONCLUSIONS: The findings offer evidence that poor patient memory for, and learning of, treatment contents extends to community settings and are transdiagnostic concerns.

Memory recollections and voluntary actions are often perceived as spontaneously generated irrespective of external stimuli. Although products of our neurons, they are only rarely accessible in humans at the neuronal level. Here I review insights gleaned from unique neurosurgical opportunities to record and stimulate single-neuron activity in people who can declare their thoughts, memories and wishes. I discuss evidence that the subjective experience of human recollection and that of voluntary action arise from the activity of two internal neuronal generators, the former from medial temporal lobe reactivation and the latter from frontoparietal preactivation. I characterize properties of these generators and their interaction, enabling flexible recruitment of memory-based choices for action as well as recruitment of action-based plans for the representation of conceptual knowledge in memories. Both internal generators operate on surprisingly explicit but different neuronal codes, which appear to arise with distinct single-neuron activity, often observed before participants' reports of conscious awareness. I discuss prediction of behaviour based on these codes, and the potential for their modulation. The prospects of editing human memories and volitions by enhancement, inception or deletion of specific, selected content raise therapeutic possibilities and ethical concerns.

Eyewitness memory researchers have recently devoted considerable attention to eyewitness confidence. While there is strong consensus that courtroom confidence is problematic, we now recognise that an eyewitness's initial confidence in their first identification - in certain contexts - can be of value. A few psychological scientists, however, have confidently, but erroneously claimed that in real-world cases, eyewitness initial confidence is the most important indicator of eyewitness accuracy, trumping all other factors that might exist in a case. This claim accompanies an exaggeration of the role of eyewitnesses' "initial confidence" in the DNA exoneration cases. Still worse, overstated claims about the confidence-accuracy relationship, and eyewitness memory, have reached our top scientific journals, news articles, and criminal cases. To set the record straight, we review what we actually know and do not know about the "initial confidence" of eyewitnesses in the DNA exoneration cases. Further reasons for skepticism about the value of the confidence-accuracy relationship in real-world cases come from new analyses of a separate database, the National Registry of Exonerations. Finally, we review new research that reveals numerous conditions wherein eyewitnesses with high initial confidence end up being wrong.

Although older adults are often concerned about instances of forgetting, forgetting can be a useful feature of our memory system. Specifically, strategically forgetting less important information can benefit memory for goal-relevant information (i.e., responsible remembering and responsible forgetting). In two experiments, we presented younger and older adults with a list of words (either unrelated words or items to bring on a camping trip) with a cue indicating whether participants (You) or their Friend was responsible for remembering each item. Results revealed that both younger and older adults engaged in responsible remembering and forgetting by better remembering items they were responsible for remembering, indicating a strategic utilization of their limited memory capacity. Additionally, regardless of age and the cue indicating who was responsible for remembering each item, participants used importance to guide the encoding and retrieval of information. Thus, people may be able to engage strategic cognitive mechanisms to maximize memory utility for important, goal-relevant information, and responsible forgetting can enhance memory utility in both younger and older adults by using importance to drive memory and reduce consequences for forgetting.

Tax audits are a crucial process adopted in all tax departments to ensure tax compliance and fairness. Traditionally, tax audit leads have been selected based on empirical rules and randomization methods, which are not adaptive, may miss major cases and can introduce bias. Here, we present an audit lead tool based on artificial neural networks that have been trained and evaluated on an integrated dataset of 93,413 unique tax records from 8,647 restaurant businesses over 10 years in the Northern California, provided by the California Department of Tax and Fee Administration (CDTFA). The tool achieved a 40.1% precision and 58.7% recall (F1-score of 0.42) on classifying positive audit leads, and the corresponding regressor provided estimated audit gains (MAE of $155,490). Finally, we evaluated the statistical significance of various empirical rules for use in lead selection, with two out of five being supported by the data. This work demonstrates how data can be leveraged for creating evidence-based models of audit selection and validating empirical hypotheses, resulting in higher audit yields and more fair audit selection processes.

Roughly two-thirds of all people report having experienced déjà vu-the odd feeling that a current experience is both novel and a repeat or replay of a previous, unrecalled experience. Reports of an association between déjà vu and seizure aura symptomatology have accumulated for over a century, and frequent déjà vu is also now known to be associated with focal seizures, particularly those of a medial temporal lobe (MTL) origin. A longstanding question is whether seizure-related déjà vu has the same basis and is the same subjective experience as non-seizure déjà vu. Survey research suggests that people who experience both seizure-related and non-seizure déjà vu can often subjectively distinguish between the two. We present a case of a person with a history of focal MTL seizures who reports having experienced both seizure-related and non-seizure common déjà vu, though the non-seizure type was more frequent during this person's youth than it is currently. The patient was studied with a virtual tour paradigm that has previously been shown to elicit déjà vu among non-clinical, young adult participants. The patient reported experiencing déjà vu of the common non-seizure type during the virtual tour paradigm, without associated abnormalities of the intracranial EEG. We situate this work in the context of broader ongoing projects examining the subjective correlates of seizures. The importance for memory research of virtual scenes, spatial tasks, virtual reality (VR), and this paradigm for isolating familiarity in the context of recall failure are discussed.

Retrieval practice improves retention of tested information, and it can either impair or facilitate retention of untested information. Here, we investigated how semantic relatedness, episodic context, and sleep-dependent memory consolidation determine the effects of retrieval practice on retention of untested items. Participants studied lists of scene-word associations. Each scene was associated with two different words ("pairmates") that were either semantically related or unrelated and either in the same (temporally close) or different lists (temporally far). In three experiments, retrieval practice of scene-word associations facilitated retention of unpracticed, temporally close pairmates and impaired retention of temporally far, semantically unrelated pairmates. Critically, retrieval practice impaired retention of temporally far, semantically related pairmates if participants were unable to sleep during the retention interval, but it facilitated retention of these items if participants were able to sleep. Our findings suggest that sleep extends the benefits of testing to related information learned in temporally separate episodes.

Difficulty retrieving proper names is common in older adults, coinciding with the accumulation of aggregated proteins in mid-life. We investigated the ability of healthy older adults to retrieve the names of famous faces in relation to positron emission tomography measurements of amyloid-β plaques and tau neurofibrillary tangles. More tau in the left fusiform and parahippocampal gyrus was related to reduced proper name retrieval performance and this effect was potentiated by amyloid-β. These findings provide an explanation for a common complaint of older adults and link proper name retrieval to neural systems involved in face perception, memory, and naming. ANN NEUROL 2021;90:988-993.

Few studies have examined threat generalization across development and no developmental studies have compared the generalization of social versus nonsocial threat, making it difficult to identify contextual factors that contribute to threat learning across development. The present study assessed youth and adults multivoxel neural representations of social versus nonsocial threat stimuli. Twenty adults (Mage  = 25.7 ± 4.9) and 16 youth (Mage  = 14.1 ± 1.7) completed two conditioning and extinction recall paradigms: one social and one nonsocial paradigm. Three weeks after conditioning, participants underwent a functional magnetic resonance imaging extinction recall task that presented the extinguished threat cue (CS+), a safety cue (CS-), and generalization stimuli (GS) consisting of CS-/CS+ blends. Across age groups, neural activity patterns and self-reported fear and memory ratings followed a linear generalization gradient for social threat stimuli and a quadratic generalization gradient for nonsocial threat stimuli, indicating enhanced threat/safety discrimination for social relative to nonsocial threat stimuli. The amygdala and ventromedial prefrontal cortex displayed the greatest neural pattern differentiation between the CS+ and GS/CS-, reinforcing their role in threat learning and extinction recall. Contrary to predictions, age did not influence threat representations. These findings highlight the importance of the social relevance of threat on generalization across development.

We examined how subjective assessments of recollection guide decision making. Subjective recollection was dissociated from accuracy during a forced-choice recognition task. Distracters were either similar to targets (match condition) or to other studied, but untested items (nonmatch condition). We assessed 223 participants (112 males) across three experiments (137 White, 37 Asian-American, 7 African-American, 4 American-Indian, 32 mixed race, 6 undisclosed). In Experiment 1, 6- to 10-year-olds and adults (N = 119) were less accurate (d = 0.70), but more likely to claim subjective recollection and make memory selections in anticipation of a reward in the nonmatch condition (ds = 0.64-0.70). This pattern was eliminated in 6- to 7-year-olds when we limited the number of selections (Experiment 2, N = 52), but was replicated when we required the selections to be counted (Experiment 3, N = 52), underscoring the effects of decision complexity on children's self-reflections.

Life's events are scattered throughout time, yet we often recall different events in the context of an integrated narrative. Prior research suggests that the hippocampus, which supports memory for past events, can support the integration of overlapping associations or separate events in memory. However, the conditions that lead to hippocampus-dependent memory integration are unclear. We used functional brain imaging to test whether the opportunity to form a larger narrative (narrative coherence) drives hippocampal memory integration. During encoding of fictional stories, patterns of hippocampal activity, including activity at boundaries between events, were more similar between distant events that formed one coherent narrative, compared with overlapping events taken from unrelated narratives. One day later, the hippocampus preferentially supported detailed recall of coherent narrative events, through reinstatement of hippocampal activity patterns from encoding. These findings demonstrate a key function of the hippocampus: the integration of events into a narrative structure for memory.

ABSTRACTSerial position effects are often observed within the free recall of unassociated words but also when recalling items from a semantic category like U.S. presidents. We investigated the dynamics of recall for U.S. presidents in younger and older adults to examine potential age-related differences in the organisation of retrieval from semantic long-term memory. Older adults recalled more presidents than younger adults and also demonstrated dual serial position effects such that, in addition to overall serial position effects, primacy (e.g., Eisenhower) and recency presidents (e.g., Obama) within older adults' lifetime were better recalled than presidents from the middle of their lives (e.g., Ford). Additionally, participants initiated recall with the most distinct presidents (highly familiar or memorable presidents like Washington, Obama, Trump), and conditional-response probabilities revealed that presidents from similar eras were recalled in close proximity, indicating that the retrieval of distinct presidents can facilitate memory for presidents from a similar era. Collectively, we demonstrate the potential interplay of the mechanisms that influence the organisation of retrieval such that distinctiveness and temporal contiguity effects may simultaneously impact recall. Specifically, semantic and temporal-contextual associations can drive semantic autobiographical memory and people likely organise retrieval from long-term memory according to familiarity and distinctiveness.

Given natural memory limitations, people can generally attend to and remember high-value over low-value information even when cognitive resources are depleted in older age and under divided attention during encoding, representing an important form of cognitive control. In the current study, we examined whether tasks requiring overlapping processing resources may impair the ability to selectively encode information in dual-task conditions. Participants in the divided-attention conditions of Experiment 1 completed auditory tone-distractor tasks that required them to discriminate between tones of different pitches (audio-nonspatial) or auditory channels (audio-spatial), while studying items in different locations in a grid (visual-spatial) differing in reward value. Results indicated that, while reducing overall memory accuracy, neither cross-modal auditory distractor task influenced participants' ability to selectively encode high-value items relative to a full attention condition, suggesting maintained cognitive control. Participants in Experiment 2 studied the same important visual-spatial information while completing demanding color (visual-nonspatial) or pattern (visual-spatial) discrimination tasks during study. While the cross-modal visual-nonspatial task did not influence memory selectivity, the intra-modal visual-spatial secondary task eliminated participants' sensitivity to item value. These results add novel evidence of conditions of impaired cognitive control, suggesting that the effectiveness of top-down, selective encoding processes is attenuated when concurrent tasks rely on overlapping processing resources.

The present study investigated age-related differences in retrieval from long-term memory using a semantic fluency task in which participants recalled animals during a 5-minute retrieval period. We evaluated the relative uniqueness of items and their output position within the retrieval process to further elucidate how younger and older adults access and retrieve semantic knowledge in long-term memory. Although older (n = 96, aged 56-79, M = 62.44) and younger adults (n = 98, aged 18-27, M = 23.44) scored similarly for retrieval fluency and originality, these abilities tended to decline when we analyzed age as a continuous variable, indicating some preservation in earlier adulthood, but impairment in older age. Additionally, participants tended to recall common, more easily accessible items before unique, less accessible items, and this pattern was more prominent in older adults. Thus, there are both similarities and differences in semantic fluency in older age.

To investigate if a written guide or augmented reality (AR) guide improves free recall of diversified chiropractic adjusting technique and to capture participants' impressions of the study in a poststudy questionnaire. Thirty-eight chiropractic students were evaluated for diversified listing (a nomenclature denoting vertebral malposition and correction) recall, pre-AR and post-AR, or written guide review. The vertebral segments used were C7 and T6. Two randomized groups reviewed an original course written guide (n = 18) or a new AR guide (n = 20). A Wilcoxon-Mann-Whitney (C7) and t test (T6) compared group differences in reevaluation scores. A poststudy questionnaire was given to capture participants' impressions of the study. Both groups showed no significant differences in free recall scores after reviewing the guides for C7 or T6. The poststudy questionnaire suggested a number of strategies could be used to improve current teaching material such as more detail in the written guides and organizing content into smaller blocks. Use of an AR or written guide does not seem to change participants' free recall ability when used to review diversified technique listings. The poststudy questionnaire was useful to identify strategies to improve currently used teaching material. [ABSTRACT FROM AUTHOR]

Amid rising political polarisation, inaccurate memory for facts and exaggerated memories of grievances can drive individuals and groups further apart. We assessed whether people with more accurate memories of the facts concerning political events were less susceptible to bias when remembering how events made them feel. Study 1 assessed participants' memories concerning the 2016 U.S. presidential election (N = 571), and included 33 individuals with Highly Superior Autobiographical Memory (HSAM). Study 2 assessed participants' memories concerning the 2018 referendum on abortion in Ireland (N = 733). Participants rated how happy, angry, and scared they felt days after these events. Six months later, they recalled their feelings and factual information. In both studies, participants overestimated how angry they had felt but underestimated happiness and fear. Adjusting for importance, no association was found between the accuracy of memory for facts and feelings. Accuracy in remembering facts was predicted by media exposure. Accuracy in remembering feelings was predicted by consistency over time in feelings and appraisals about past events. HSAM participants in Study 1 remembered election-related facts better than others, but not their feelings. Thus, having a good grasp of the facts did not protect against bias in remembering feelings about political events.

Three experiments studied recognition during posthypnotic amnesia (PHA) employing confidence ratings rather than the traditional yes/no format. As the criterion for recognition was loosened, an increase in hits was accompanied by an increase in false alarms, especially to distractor items that were conceptually related to, or semantically associated with, targets. Nevertheless, hits exceeded false alarms at every level of confidence. In addition, amnesic subjects had difficulty identifying the particular list on which recognized items were presented for study or the correct order in which targets appeared on the study list. Taken together, these findings support the conclusion that successful recognition during PHA is more likely to be mediated by a priming-based feeling familiarity than conscious recollection.

The ability to control both what we remember and what is forgotten can enhance memory. The present study used an item-method directed forgetting paradigm to investigate whether participants strategically remembered items they were responsible for remembering rather than items a hypothetical friend was responsible for remembering. Specifically, participants were presented with a 20-word list (either unrelated words or items to pack for a camping trip) with each word followed by a cue indicating whether the participant (You) or their "friend" (Friend) was responsible for remembering the word. When asked to recall all of the words, regardless of the cue, recall was sensitive to the You and Friend instructions such that participants demonstrated elevated recall for the items they were responsible for remembering, and participants also strategically organized retrieval by recalling You items before Friend items. Additionally, when asked to judge the importance of remembering each item, participants' recall and recognition were sensitive to item importance regardless of cue. Taken together, the present experiments revealed that the strategic encoding of important information and the forgetting of less important, goal-irrelevant information can maximize memory utility and minimize negative consequences for forgetting. Thus, we provide evidence for a metacognitive process we are calling responsible forgetting, where people attempt to forget less consequential information and focus on remembering what is most important.

BackgroundInformation on long-term dietary intake is often required for research or program planning, but surveys routinely use short-term assessments such as 24-h recalls (24HRs). Methods to reduce the impact of within-person variation in 24HRs, such as the National Cancer Institute (NCI) method, typically require extensive training and skill.ObjectivesWe introduce the Simulating Intake of Micronutrients for Policy Learning and Engagement (SIMPLE) macro, a new tool to increase the accessibility of 24HR analysis. We explain the underlying theory behind the tool and provide examples of potential applications.MethodsThe SIMPLE macro connects the core NCI statistical code to estimate usual intake distributions and includes additional code to enable advanced analyses such as predictive modeling. The related SIMPLE-Iron macro applies the full probability method to estimate inadequate iron intake, and the SIMPLE-1D macro is used for descriptive or modeling analyses of data with a single 24HR per person. The macros and associated documentations are freely available. We analyzed data from the US National Health and Nutrition Examination Survey (NHANES) and the Cameroon National Micronutrient Survey to compare the SIMPLE macro to 1) the core NCI code using the Estimated Average Requirement cut point method, and 2) the IMAPP software for iron only, and to demonstrate the applications of the SIMPLE macro for estimating usual intake and predictive modeling.ResultsThe SIMPLE macro generates identical results to the core NCI code. The SIMPLE-Iron macro also produces estimates of inadequate iron intake comparable to the IMAPP software. The examples demonstrate application of the SIMPLE macro to 1) descriptive analyses of nutrient intake from food and supplements (NHANES), and 2) analyses accounting for breast-milk nutrient intake and modeling fortification and supplementation programs (Cameroon).ConclusionsThe SIMPLE macros may facilitate the analysis and modeling of dietary data to inform nutrition research, programs, and policy.

Our objective was to examine the construct validity of the Brief Test of Adult Cognition by Telephone (BTACT) and its relationship to traumatic brain injury (TBI) of differing severities. Data were analyzed on 1422 patients with TBI and 170 orthopedic trauma controls (OTC) from the multi-center Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) study. Participants were assessed at 6 months post-injury with the BTACT and an in-person neuropsychological battery. We examined the BTACT's factor structure, factorial group invariance, convergent and discriminant validity, and relationship to TBI and TBI severity. Confirmatory factor analysis supported both a 1-factor model and a 2-factor model comprising correlated Episodic Memory and Executive Function (EF) factors. Both models demonstrated strict invariance across TBI severity and OTC groups. Correlations between BTACT and criterion measures suggested that the BTACT memory indices predominantly reflect verbal episodic memory, whereas the BTACT EF factor correlated with a diverse range of cognitive tests. Although the EF factor and other BTACT indices showed significant relationships with TBI and TBI severity, some group effect sizes were larger for more comprehensive in-person cognitive tests than the BTACT. The BTACT is a promising, brief, phone-based cognitive screening tool for patients with TBI. Although the BTACT's memory items appear to index verbal Episodic Memory, items that purport to assess EFs may reflect a broader array of cognitive domains. The sensitivity of the BTACT to TBI severity is lower than domain-specific neuropsychological measures, suggesting it should not be used as a substitute for comprehensive, in-person cognitive testing at 6 months post-TBI.

Almost all models of visual working memory-the cognitive system that holds visual information in an active state-assume it has a fixed capacity: Some models propose a limit of three to four objects, where others propose there is a fixed pool of resources for each basic visual feature. Recent findings, however, suggest that memory performance is improved for real-world objects. What supports these increases in capacity? Here, we test whether the meaningfulness of a stimulus alone influences working memory capacity while controlling for visual complexity and directly assessing the active component of working memory using EEG. Participants remembered ambiguous stimuli that could either be perceived as a face or as meaningless shapes. Participants had higher performance and increased neural delay activity when the memory display consisted of more meaningful stimuli. Critically, by asking participants whether they perceived the stimuli as a face or not, we also show that these increases in visual working memory capacity and recruitment of additional neural resources are because of the subjective perception of the stimulus and thus cannot be driven by physical properties of the stimulus. Broadly, this suggests that the capacity for active storage in visual working memory is not fixed but that more meaningful stimuli recruit additional working memory resources, allowing them to be better remembered.

Adaptive memory refers to the memory advantage for information processed in a survival and/or reproduction context while metacognition involves the awareness of what we can later remember. The notion of "responsible remembering" captures how memory functions to prioritise important information that will need to be remembered and how metacognitive processes may be more precise in situations involving consequences for forgetting. In 5 experiments, we examined whether judgments of learning and judgments of importance affect recall selectivity for information with negative consequences if forgotten. We presented participants with lists of children, each with 2 foods they like, 2 foods they dislike, and 2 foods they are allergic to. When making no metacognitive judgments or making JOLs for each food preference, participants best recalled foods the children liked, likely resulting from serial remembering (recalling information according to where it was presented). However, when judging the importance of remembering items, participants were strategic in their memory for the food preferences such that they best recalled information they rated as important to remember (allergies). These results suggest that when forced to consider the importance of remembering, participants engage in responsible remembering by deeming information with consequences for forgetting as most important and subsequently best remembering this information.

The original and second editions of the California Verbal Learning Test (CVLT) used nonparametric and parametric methods, respectively, to assess Total Recognition Discriminability (RD). In a previous study, we found evidence that the nonparametric formula may be more sensitive than the parametric formula to high false positive (FP) rates and provide more accurate assessments of yes/no recognition in neurodegenerative populations prone to high FP rates, including Alzheimer's disease (AD). In the present study, we extended our investigation to examine the utility of CVLT-3 nonparametric and parametric Total RD indices in the assessment and comparison of yes/no recognition in individuals with Huntington's disease (HD) and AD in mild and moderate stages of dementia. Findings suggested that the CVLT-3 nonparametric Total RD index was more sensitive than the parametric index to HD and AD differences in yes/no recognition across mild and moderate stages of dementia. Additionally, group differences on total FP errors were more closely mirrored by group differences on the nonparametric Total RD index. The present results bolster our previous findings and highlight the utility of examining nonparametric (in addition to parametric) Total RD on the CVLT-3 in assessments of yes/no recognition involving clinical populations prone to high FP rates.

Episodic memory is critical to human functioning. In adults, episodic memory involves a distributed neural circuit in which the hippocampus plays a central role. As episodic memory abilities continue to develop across childhood and into adolescence, studying episodic memory maturation can provide insight into the development and construction of these hippocampal networks, and ultimately clues to their function in adulthood. While past developmental studies have shown that the hippocampus helps to support memory in middle childhood and adolescence, the extent to which ongoing maturation within the hippocampus contributes to developmental change in episodic memory abilities remains unclear. In contrast, slower maturing regions, such as the PFC, have been suggested to be the neurobiological locus of memory improvements into adolescence. However, it is also possible that the methods used to detect hippocampal development during middle childhood and adolescence are not sensitive enough. Here, we examine how temporal covariance (or differentiation) in voxel representations within anterior and posterior hippocampus change with age to support the development of detailed recollection in male and female developing humans. We find age-related increases in the distinctiveness of temporal activation profiles in the posterior, but not anterior, hippocampus. Second, we show that this measure of granularity, when present during postencoding rest periods, correlates with the recall of detailed memories of preceding stimuli several weeks postencoding, suggesting that granularity may promote memory stabilization.SIGNIFICANCE STATEMENT Studying hippocampal maturation can provide insight into episodic memory development, as well as clues to episodic functioning in adulthood. Past work has shown evidence both for and against hippocampal contributions to age-related improvements in memory performance, but has relied heavily on univariate approaches (averaging activity across hippocampal voxels), which may not be sensitive to nuanced developmental change. Here we use a novel approach, examining time signatures in individual hippocampal voxels to reveal regionally specific (anterior vs posterior hippocampus) differences in the distinctiveness (granularity) of temporal activation profiles across development. Importantly, posterior hippocampus granularity during windows of putative memory stabilization was associated with long-term memory specificity. This suggests that the posterior hippocampus gradually builds the capacity to support detailed episodic recall.

A typical police lineup contains a photo of one suspect (who is innocent in a target-absent lineup and guilty in a target-present lineup) plus photos of five or more fillers who are known to be innocent. To create a fair lineup in which the suspect does not stand out, two filler selection methods are commonly used. In the first, fillers are selected if they are similar in appearance to the suspect. In the second, fillers are selected if they possess facial features included in the witness's description of the culprit (e.g., "20-y-old white male"). The police sometimes use a combination of the two methods by selecting description-matched fillers whose appearance is also similar to that of the suspect in the lineup. Decades of research on which approach is better remains unsettled. Here, we tested a counterintuitive prediction made by a formal model based on signal detection theory: From a pool of acceptable description-matched photos, selecting fillers whose appearance is otherwise dissimilar to the suspect should increase the hit rate without affecting the false-alarm rate (increasing discriminability). In Experiment 1, we confirmed this prediction using a standard mock-crime paradigm. In Experiment 2, the effect on discriminability was reversed (as also predicted by the model) when fillers were matched on similarity to the perpetrator in both target-present and target-absent lineups. These findings suggest that signal-detection theory offers a useful theoretical framework for understanding eyewitness identification decisions made from a police lineup.

Curiosity states benefit memory for target information, but also incidental information presented during curiosity states. However, it is not known whether incidental curiosity-enhanced memory depends on when incidental information during curiosity states is encountered. Here, participants incidentally encoded unrelated face images at different time points while they anticipated answers to trivia questions. Across two experiments, we found memory enhancements for unrelated faces presented during high-curiosity compared with low-curiosity states, but only when presented shortly after a trivia question. This suggests processes associated with the elicitation of curiosity-but not sustained anticipation or the satisfaction of curiosity-enhance memory for incidental information.

Nonhuman research has implicated developmental processes within the hippocampus in the emergence and early development of episodic memory, but research in humans has been constrained by the difficulty of examining hippocampal function during early development. In the present study, we assessed 48 2-year-olds with a novel paradigm in which participants completed two games on a tablet that required remembering associations between unique characters, the places they visited, and the temporal order with which they did so. At the completion of each game, a unique, novel song played. Toddlers remembered spatial locations better than temporal order during an immediate test, after a 20-minute delay, and after a week delay. After the last behavioral session, toddlers underwent an fMRI task during natural nocturnal sleep evaluating hippocampal activation in response to learned and novel songs. We found that the extent of hippocampal activation for learned songs compared to novel songs during sleep was correlated with memory for temproal order across all time delays, but not with memory for spatial locations. The results confirm that that the functional contribution of the hippocampus to early memory can be assessed during sleep and suggest that assessment of temporal aspects of memory in the current task best capture this contribution.

The memories that we retain can serve many functions. They guide our future actions, form a scaffold for constructing the self, and continue to shape both the self and the way we perceive the world. Although most memories we acquire each day are forgotten, those integrated within the structure of multiple prior memories tend to endure. A rapidly growing body of research is steadily elucidating how the consolidation of memories depends on their reactivation during sleep. Processing memories during sleep not only helps counteract their weakening but also supports problem solving, creativity, and emotional regulation. Yet, sleep-based processing might become maladaptive, such as when worries are excessively revisited. Advances in research on memory and sleep can thus shed light on how this processing influences our waking life, which can further inspire the development of novel strategies for decreasing detrimental rumination-like activity during sleep and for promoting beneficial sleep cognition.

Accurate memories are often associated with vivid experiences of recollection. However, the neural mechanisms underlying subjective recollection and their unique role in decision making beyond accuracy have received limited attention. We dissociated subjective recollection from accuracy during a forced-choice task. Distractors corresponded either to non-studied exemplars of the targets (A-A' condition) or to non-studied exemplars of different studied items (A-B' condition). The A-A' condition resulted in higher accuracy and greater activation in the superior parietal lobe, whereas the A-B' condition resulted in higher subjective recollection and greater activation in the precuneus and retrosplenial regions, indicating a dissociation between objective and subjective memory. Activation in insular, cingulate, and lateral prefrontal regions was also associated with subjective recollection; however, during a subsequent decision phase, activation in these same regions was greater for discarded than for selected responses in anticipation of a social reward, underscoring their role in evaluating memory evidence flexibly based on current goals.

Recent studies have shown higher resting-state vagally-mediated heart rate variability (vmHRV) to be related to greater memory retrieval. Research has not yet linked resting vmHRV with memory encoding and retrieval, as both are thought to play an important role in correctly distinguishing between true and false memories. The current study investigated this possible link in n = 71 undergraduate students. VmHRV was assessed during a 5-minute resting baseline period. Participants then completed the Deese-Roediger-McDermott (DRM) task, where they first viewed 6 word lists (12 words per list), and were later asked to identify previously shown words (true memories) and reject non-presented words. Results showed that participants with lower resting vmHRV were less able to discriminate true from false items. These data extend previous work on resting vmHRV and memory suggesting that resting vmHRV represents a psychophysiological pathway involved in both the proper encoding and retrieval of memories.

Sleep's role in memory consolidation is widely acknowledged, but its role in weakening memories is still debated. Memory weakening is evolutionary beneficial and makes an integral contribution to cognition. We sought evidence on whether sleep-based memory reactivation can facilitate memory suppression. Participants learned pairs of associable words (e.g., DIET-CREAM) and were then exposed to hint words (e.g., DIET) and instructed to either recall ("think") or suppress ("no-think") the corresponding target words (e.g., CREAM). As expected, suppression impaired retention when tested immediately after a 90-min nap. To test if reactivation could selectively enhance memory suppression during sleep, we unobtrusively presented one of two sounds conveying suppression instructions during sleep, followed by hint words. Results showed that targeted memory reactivation did not enhance suppression-induced forgetting. Although not predicted, post-hoc analyses revealed that sleep cues strengthened memory, but only for suppressed pairs that were weakly encoded before sleep. The results leave open the question of whether memory suppression can be augmented during sleep, but suggest strategies for future studies manipulating memory suppression during sleep. Additionally, our findings support the notion that sleep reactivation is particularly beneficial for weakly encoded information, which may be prioritized for consolidation.

A growing body of evidence suggests that sleep can help to decouple the memory of emotional experiences from their associated affective charge. This process is thought to rely on the spontaneous reactivation of emotional memories during sleep, though it is still unclear which sleep stage is optimal for such reactivation. We examined this question by explicitly manipulating memory reactivation in both rapid-eye movement sleep (REM) and slow-wave sleep (SWS) using targeted memory reactivation (TMR) and testing the impact of this manipulation on habituation of subjective arousal responses across a night. Our results show that TMR during REM, but not SWS significantly decreased subjective arousal, and this effect is driven by the more negative stimuli. These results support one aspect of the sleep to forget, sleep to remember (SFSR) hypothesis which proposes that emotional memory reactivation during REM sleep underlies sleep-dependent habituation.

Working memory (WM) deficits are key in attention deficit hyperactivity disorder (ADHD). Nevertheless, WM is not universally impaired in ADHD. Additionally, the neural basis for WM deficits in ADHD has not been conclusively established, with regions including the prefrontal cortex, cerebellum, and caudate being implicated. These contradictions may be related to conceptualizations of WM capacity, such as load (amount of information) versus operational-complexity (maintenance-recall or manipulation). For instance, relative to neurotypical (NT) individuals, complex WM operations could be impaired in ADHD, while simpler operations are spared. Alternatively, all operations may be impaired at higher loads. Here, we compared the impact of these two components of WM capacity: load and operational-complexity, between ADHD and NT, behaviorally and neurally. We hypothesized that the impact of WM load would be greater in ADHD, and the neural activation would be altered. Participants (age-range 12-23 years; 50 ADHD (18 females); 82 NT (41 females)) recalled three or four objects (load) in forward or backward order (operational-complexity) during functional magnetic resonance imaging scanning. The effects of diagnosis and task were compared on performance and neural engagement. Behaviorally, we found significant interactions between diagnosis and load, and between diagnosis, load, and complexity. Neurally, we found an interaction between diagnosis and load in the right striatum, and between diagnosis and complexity in the right cerebellum and left occipital gyrus. The ADHD group displayed hypo-activation compared to NT group during higher load and greater complexity. This informs mechanisms of functional problems related to WM in adolescents and young adults with ADHD (e.g., academic performance) and remedial interventions (e.g., WM-training).

One common and unfortunately overlooked obstacle to the detection of sexual abuse is non-disclosure by children. Non-disclosure in forensic interviews may be expressed via concealment in response to recall questions or via active denials in response to recognition (e.g., yes/no) questions. In two studies, we evaluated whether adults' ability to discern true and false denials of wrongdoing by children varied as a function of the types of interview question the children were asked. Results suggest that adults are not good at detecting deceptive denials of wrongdoing by children, even when the adults view children narrate their experiences in response to recall questions rather than provide one word answers to recognition questions. In Study 1, adults exhibited a consistent "truth bias," leading them toward believing children, regardless of whether the children's denials were true or false. In Study 2, adults were given base-rate information about the occurrence of true and false denials (50% of each). The information eliminated the adults' truth bias but did not improve their overall detection accuracy, which still hovered near chance. Adults did, however, perceive children's denials as slightly more credible when they emerged in response to recall rather than recognition questions, especially when children were honestly denying wrongdoing. Results suggest the need for caution when evaluating adults' judgments of children's veracity when the children fail to disclose abuse.

Culture influences how people cope with interpersonal tensions, with those from more collectivistic contexts (e.g. Chinese Americans (CA)) generally opting for strategies promoting social harmony whereas those from more individualistic contexts (e.g. European Americans (EA)) preferring confrontational strategies. The current study examined cultural differences in coping strategy choices and their linkages to immediate affective reactions and subsequent affective memories. Participants (N = 159) discussed hypothetical dilemmas with a disagreeable confederate matched by age group, gender, and cultural group. CA exhibited less positive affect reactivity (i.e. smaller decreases in positive affect) and greater positive affect recovery (i.e. greater increases in post-task positive affect) compared to EA, which was explained by CAs appraisals of greater emotional support from the confederate and lower endorsement of defending ones opinions. In contrast, one week later, EA, but not CA, recalled experiencing more task positive affect and less task negative affect than originally reported. Cultural differences in negative affect memory discrepancies were explained by EAs greater tendency to defend their opinions, relative to CA. Culture shapes coping choices, which predict affective consequences over different time scales.

Although individuals with autism spectrum disorder (ASD) have been often shown to display similar memory performance on semantic memory tasks compared to typically developing (TD) children, there is ongoing debate about whether and how their ability to remember specific past events (i.e., episodic memory) is impaired. We assessed a sample of 62 children with ASD and 72 TD children, ranging in age between 8 and 12 years on 2 memory tasks. Participants encoded a series of images and their association with either where they appeared on the screen (item-space association task) or with the color of an image's border (item-color association task). Children with ASD showed worse memory in the item-space association task compared to their TD peers, but comparable memory for the item-color association task. These differences persisted when age, intellectual quotient, and general item recognition memory were accounted for statistically. We interpret these results in light of evidence for specific deficits along the dorsal stream affecting processing of spatiotemporal information in ASD. Autism Res 2020, 13: 1985-1997. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: Episodic memory requires the ability to bind contextual details (such as color, location, etc.) to an item or event in order to remember the past with specific detail. Here, we compared children with autism spectrum disorder (ASD) and typically developing (TD) children on tasks examining episodic memory. Children with ASD recalled more poorly previously seen items and their associated space-related details, but they performed comparably to TD children on color details. We discuss the possible mechanisms that contribute to worse spatial processing/recall in ASD.

The memories we form are determined by what we attend to, and conversely, what we attend to is influenced by our memory for past experiences. Although we know that shifts of attention via eye movements are related to memory during encoding and retrieval, the role of specific memory processes in this relationship is unclear. There is evidence that attention may be especially important for some forms of memory (i.e., conscious recollection), and less so for others (i.e., familiarity-based recognition and unconscious influences of memory), but results are conflicting with respect to both the memory processes and eye movement patterns involved. To address this, we used a confidence-based method of isolating eye movement indices of spatial attention that are related to different memory processes (i.e., recollection, familiarity strength, and unconscious memory) during encoding and retrieval of real-world scenes. We also developed a new method of measuring the dispersion of eye movements, which proved to be more sensitive to memory processing than previously used measures. Specifically, in 2 studies, we found that familiarity strength-that is, changes in subjective reports of memory confidence-increased with (a) more dispersed patterns of viewing during encoding, (b) less dispersed viewing during retrieval, and (c) greater overlap in regions viewed between encoding and retrieval (i.e., resampling). Recollection was also related to these eye movements in a similar manner, though the associations with recollection were less consistent across experiments. Furthermore, we found no evidence for effects related to unconscious influences of memory. These findings indicate that attentional processes during viewing may not preferentially relate to recollection, and that the spatial distribution of eye movements is directly related to familiarity-based memory during encoding and retrieval. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

The hippocampus plays an essential role in the formation and retrieval of episodic memories in humans and contextual memories in animals. However, amnesia is not always observed when this structure is compromised. To determine why this is the case, we compared the effects of several different circuit manipulations on memory retrieval and hippocampal activity. Mice were first trained on context fear conditioning and then optogenetic and chemogenetic tools were used to alter activity during memory retrieval. We found that retrieval was only impaired when manipulations caused widespread changes (increases or decreases) in hippocampal activity. Widespread increases occurred when pyramidal cells were excited and widespread decreases were found when GABAergic neurons were stimulated. Direct hyperpolarization of excitatory neurons only moderately reduced activity and did not produce amnesia. Surprisingly, widespread decreases in hippocampal activity did not prevent retrieval if they occurred gradually prior to testing. This suggests that intact brain regions can express contextual memories if they are given adequate time to compensate for the loss of the hippocampus.

The ability to remember our past depends critically on the hippocampus and ventromedial prefrontal cortex (vmPFC), but their respective roles are debated. Contrary to classic theories, recent work (McCormick et al.) has shown that vmPFC drives the hippocampus during memory retrieval, irrespective of how old the recalled memories are.

Visual working memory is the ability to hold visual information temporarily in mind. A key feature of working memory is its starkly limited capacity, such that only a few simple items can be remembered at once. Prior work has shown that this capacity limit cannot be circumvented by providing additional encoding time, whether providing just 200 ms or up to 1300 ms, capacity is still limited to only three to four items. In contrast, Brady et al. (2016) hypothesized that real-world objects, but not simple items used in prior research, benefit from additional encoding time and are not subject to traditional capacity limits. They supported this hypothesis with results from both behavior and the contralateral delay activity (CDA), an EEG marker of working memory storage, and concluded that familiar, complex stimuli are necessary to observe encoding time effects. Here, we conducted three replications of Brady et al.'s key manipulation with a larger number of human participants and more trials per condition. We failed to replicate their primary behavioral result (objects benefit more than colors from additional encoding time) and failed to observe an object-specific increase in the CDA. Instead, we found that encoding time benefitted both simple color items and real-world objects, in contrast to both the findings by Brady et al., and some prior work on this topic. Overall, we observed no support for the hypothesis that real-world objects have a different capacity than colored squares. We discuss the implications of our findings for theories of visual working memory (VWM).

BackgroundProviding early psychosis (EP) individuals with family psychoeducation (FPE) can reduce symptoms and improve clinical outcomes. However, relational memory problems may limit prospective utilization of FPE information. This study examines whether memory for FPE can be improved by testing participants during the initial FPE workshop presentation.MethodData were obtained from 20 people with EP and 20 demographically matched healthy comparison subjects (HC). During session one, FPE was presented in small group workshops, with half of the information re-studied twice (re-study condition) and the remaining information tested twice using cued recall tasks (retrieval practice condition). One week later (session two), delayed cued recall was tested for all FPE information. "Testing effects" (i.e., better memory following retrieval practice versus re-study) were examined across all items (standard analysis) and also limited to items successfully retrieved during session one (conditionalized analysis).ResultsHC had better initial recall and learned more over the two retrieval practice trials than EP. However, HC also lost more information than EP over the one-week delay. Both groups produced a significant testing effect. This effect was smaller in EP versus HC across all test items, but did not differ for the conditionalized analysis. Negative symptoms were inversely correlated with delayed cued recall in EP.ConclusionsEP participants benefit from retrieval practice, with participants with less severe negative symptoms showing the greatest benefit. These results encourage use of memory tests during group psychoeducation to improve subsequent long-term recall of clinically relevant information.

BackgroundImpairments in spatial working memory (sWM) have been well documented in schizophrenia. Here we provide a comprehensive test of a microcircuit model of WM performance in schizophrenia that predicts enhanced effects of increasing delay duration and distractors based on a hypothesized imbalance of excitatory and inhibitory processes.MethodsModel predictions were tested in 41 people with schizophrenia (PSZ) and 32 healthy control subjects (HCS) performing an sWM task. In one condition, a single target location was followed by delays of 0, 2, 4, or 8 seconds. In a second condition, distractors were presented during the 4-second delay interval at 20°, 30°, 40°, 50°, or 90° from the original target location.ResultsPSZ showed less precise sWM representations than HCS, and the rate of memory drift over time was greater in PSZ than in HCS. Relative to HCS, the spatial recall responses of PSZ were more repelled by distractors presented close to the target location and more attracted by distractors presented far from the target location. The degree of attraction to distant distractors was correlated with the rate of memory drift in the absence of distractors.ConclusionsConsistent with the microcircuit model, PSZ exhibited both a greater rate of drift and greater attraction to distant distractors relative to HCS. These two effects were correlated, consistent with the proposal that they arise from a single underlying mechanism. However, the repulsion effects produced by nearby distractors were not predicted by the model and thus require an updated modeling framework.

Long-term memory is often considered easily corruptible, imprecise, and inaccurate, especially in comparison to working memory. However, most research used to support these findings relies on weak long-term memories: those where people have had only one brief exposure to an item. Here we investigated the fidelity of visual long-term memory in more naturalistic setting, with repeated exposures, and ask how it compares to visual working memory fidelity. Using psychophysical methods designed to precisely measure the fidelity of visual memory, we demonstrate that long-term memory for the color of frequently seen objects is as accurate as working memory for the color of a single item seen 1 s ago. In particular, we show that repetition greatly improves long-term memory, including the ability to discriminate an item from a very similar item (fidelity), in both a lab setting (Experiments 1-3) and a naturalistic setting (brand logos, Experiment 4). Overall, our results demonstrate the impressive nature of visual long-term memory fidelity, which we find is even higher fidelity than previously indicated in situations involving repetitions. Furthermore, our results suggest that there is no distinction between the fidelity of visual working memory and visual long-term memory, but instead both memory systems are capable of storing similar incredibly high-fidelity memories under the right circumstances. Our results also provide further evidence that there is no fundamental distinction between the "precision" of memory and the "likelihood of retrieving a memory," instead suggesting a single continuous measure of memory strength best accounts for working and long-term memory. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

People often need to remember the location of important objects or events, and also to remember locations that are associated with negative objects. In the current study, we examined how both positive and negative items might be selectively remembered in the visuospatial domain. Participants studied number-items ranging from -25 to +25 indicating point values in a grid display and were instructed to maximize their score (a summation of correctly remembered positive and negative information; incorrectly placed negative items resulted in a subtraction from the overall score). Items were presented in a sequential, simultaneous (Experiment 1), or self-regulated format (Experiment 2) where participants controlled which items to study and the length of study time per item. In Experiment 1, participants selectively recalled high-magnitude over low-magnitude items, but also displayed a positivity preference in memory. In Experiment 2, we were able to determine whether this positivity preference was a result of bottom-up, automatic, or top-down strategic processes. Results indicated that participants explicitly chose to study positive items more frequently and for more total time relative to negative items, suggesting a deliberate strategy to focus on positive information. This bias for highly positive information suggests an overt points-gained approach, as opposed to a loss-aversion approach, to remembering value in the visuospatial domain.

OBJECTIVE: There is lack of Cameroonian adult neuropsychological (NP) norms, limited knowledge concerning HIV-associated neurocognitive disorders in Sub-Saharan Africa, and evidence of differential inflammation and disease progression based on viral subtypes. In this study, we developed demographically corrected norms and assessed HIV and viral genotypes effects on attention/working memory (WM), learning, and memory. METHOD: We administered two tests of attention/WM [Paced Auditory Serial Addition Test (PASAT)-50, Wechsler Memory Scale (WMS)-III Spatial Span] and two tests of learning and memory [Brief Visuospatial Memory Test-Revised (BVMT-R), Hopkins Verbal Learning Test-Revised (HVLT-R)] to 347 HIV+ and 395 seronegative adult Cameroonians. We assessed the effects of viral factors on neurocognitive performance. RESULTS: Compared to controls, people living with HIV (PLWH) had significantly lower T-scores on PASAT-50 and attention/WM summary scores, on HVLT-R total learning and learning summary scores, on HVLT-R delayed recall, BVMT-R delayed recall and memory summary scores. More PLWH had impairment in attention/WM, learning, and memory. Antiretroviral therapy (ART) and current immune status had no effect on T-scores. Compared to untreated cases with detectable viremia, untreated cases with undetectable viremia had significantly lower (worse) T-scores on BVMT-R total learning, BVMT-R delayed recall, and memory composite scores. Compared to PLWH infected with other subtypes (41.83%), those infected with HIV-1 CRF02_AG (58.17%) had higher (better) attention/WM T-scores. CONCLUSIONS: PLWH in Cameroon have impaired attention/WM, learning, and memory and those infected with CRF02_AG viruses showed reduced deficits in attention/WM. The first adult normative standards for assessing attention/WM, learning, and memory described, with equations for computing demographically adjusted T-scores, will facilitate future studies of diseases affecting cognitive function in Cameroonians.

When we look at repeated scenes, we tend to visit similar regions each time-a phenomenon known as resampling Resampling has long been attributed to episodic memory, but the relationship between resampling and episodic memory has recently been found to be less consistent than assumed. A possibility that has yet to be fully considered is that factors unrelated to episodic memory may generate resampling: for example, other factors such as semantic memory and visual salience that are consistently present each time an image is viewed and are independent of specific prior viewing instances. We addressed this possibility by tracking participants' eyes during scene viewing to examine how semantic memory, indexed by the semantic informativeness of scene regions (i.e., meaning), is involved in resampling. We found that viewing more meaningful regions predicted resampling, as did episodic familiarity strength. Furthermore, we found that meaning interacted with familiarity strength to predict resampling. Specifically, the effect of meaning on resampling was attenuated in the presence of strong episodic memory, and vice versa. These results suggest that episodic and semantic memory are each involved in resampling behavior and are in competition rather than synergistically increasing resampling. More generally, this suggests that episodic and semantic memory may compete to guide attention.

BackgroundHeavy alcohol use negatively impacts neurocognition, but some studies report neurocognitive benefits associated with light drinking among HIV-seronegative (HIV-) older persons, suggesting a nonlinear or an inverted "J-shaped" association of alcohol consumption on neurocognition. Alcohol use is common among people with HIV (PWH); however, the association between recent "low-risk" alcohol consumption and neurocognition among PWH is poorly understood.MethodsParticipants included 310 PWH and 89 HIV- older (≥50 years) adults who reported alcohol abstinence or "low-risk" drinking, defined per the National Institute on Alcohol Abuse and Alcoholism criteria (i.e., ≥15 drinks/wk or ≥5 drinks/d for men; ≥8 drinks/wk or ≥4 drinks/d for women). Neurocognition was measured using global and domain-specific demographically corrected T-scores. Multiple linear regressions examined the interaction between total drinks in the last 30 days (linear and quadratic terms) and HIV serostatus on neurocognition, covarying for age, sex, lifetime major depressive disorder, lifetime nonalcohol substance use disorders, and lifetime alcohol use disorder.ResultsTotal drinks consumed in the last 30 days did not differ by HIV serostatus (p = 0.202). Among HIV- older adults, quadratic effects of total drinks on neurocognition occurred such that optimal neurocognition (i.e., global function, executive function, learning, delayed recall, and motor skills) was detected at intermediate levels of "low-risk" drinking (~20 to 40 drinks), with poorer performance at the lower and higher ranges of "low-risk" consumption. In PWH, total drinks did not exhibit linear or quadratic associations with neurocognition.ConclusionsIn HIV- "low-risk" drinkers, intermediate levels of recent alcohol use were associated with better neurocognition, consistent with the inverted J-shaped association. The same nonlinear effect of recent alcohol consumption on neurocognition was absent in PWH, indicating there may be no beneficial or deleterious effects of low-risk alcohol consumption on neurocognition among PWH. Future research is warranted to examine associations between alcohol consumption and HIV-related biopsychosocial disadvantages that may supersede the neurocognitive benefits of alcohol.