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462 results on '"Merhi, Zaher"'

60. Effect of intraovarian PRP injection in woman with poor ovarian reserve is still open to debate.

Author

Merhi, Zaher

Subjects
*OVARIAN reserve, *PLATELET-derived growth factor, *CARDIOVASCULAR system, *GRANULOSA cells, *PLATELET-rich plasma
Abstract

The article discusses a study on the use of intraovarian platelet-rich plasma (PRP) injections in women with poor ovarian response (POR). The study raises questions about the methodology and results of the trial. It questions the preparation and administration of the PRP, as well as the sample size calculation. The article concludes that more standardized research is needed to determine the effectiveness of PRP for women with POR. The author declares no conflict of interest. [Extracted from the article]

Published
2024
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63. Impact of dramatic weight loss with the new injectable medications on reproduction in healthy non–polycystic ovary syndrome obese women

Author

Merhi, Zaher

Abstract

The intake of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) in obese women with polycystic ovary syndrome (PCOS) demonstrated improvement in metabolic and reproductive symptoms; however, their impact in non-PCOS state is unclear. This review critically analyzes data pertaining to GLP-1 RAs in non-PCOS females in both humans and animals, with a focus on their impact on the hypothalamic-pituitary-ovarian axis and the uterine function. In animal models, studies showed controversial results. The intracerebroventricular GLP-1 administration caused stimulatory reproductive effects, where it increased the amplitude of the luteinizing hormone surge, follicle-stimulating hormone (FSH) secretion, serum progesterone levels, up-regulation in Kiss-1rexpression in the hypothalamus, and increase in ovarian Graafian follicles and corpora lutea. However, the intracerebroventricular GLP-1 RA Exendin-4 and the subcutaneous GLP-1 RA liraglutide resulted in opposite effects. Even though GLP-1 up-regulated FSH receptor messenger ribonucleic acid expression in granulosa cells, it led to a suppression in FSH-induced progesterone synthesis. The effect of GLP-1 RA on the uterus also showed controversial findings. Although some data showed that GLP-1 RA had a beneficial antifibrotic effect in intrauterine adhesions model by reducing the deposition area of collagen fibers, other data showed that exposure to GLP-1 RA resulted in destruction of the luminal epithelium with shrinkage in muscle fiber. It is unclear how these GLP-1 RA medications impact future fertility in humans because most studies to date had significant limitations and were performed in animals with contentious findings. There is a clear need to study this relationship because many reproductive-aged women without PCOS are resorting to these medications for weight loss purposes.

Published
2025
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80. Monocyte chemotactic protein-1 plays a role in ovarian dysfunction related to high-fat diet-induced obesity

Author

Obehi Asemota, Thornton, Kimberley, Merhi, Zaher, Berger, Dara S., Williams, Lyda, Seki, Yoshinori, Du, Xiu Quan, Jindal, Sangita, Charron, Maureen J., and Buyuk, Erkan

Abstract

Obesity, known to cause a systemic elevation in monocyte chemotactic protein-1 (MCP-1), adversely affects normal ovarian function. The aim of this study was to determine whether MCP-1 plays a role in ovarian dysfunction that is related to obesity induced by high-fat (HF) diet intake. Wild type (WT) C57BL/6J mice were fed either normal chow (NC) (Group 1, control group) or HF diet (Group 2). To assess whether MCP-1 is involved in HF-diet-induced ovarian dysfunction, MCP-1 knock-out mice were fed HF diet (Group 3). Body weight, body fat composition, number of oocytes collected following ovarian superovulation with gonadotropins, ovarian macrophage markers and expression of genes important in folliculogenesis and steroidogenesis were quantified in the 3 groups of animals. Animals in Group 2 gained significant body weight and body mass, produced the fewest number of oocytes following superovulation, and had significant alterations in ovarian genes involved in folliculogenesis and steroidogenesis as well as genes involved in inflammation. Although animals in Group 3 had the highest body weight and body fat composition, they produced similar number of oocytes compared to animals in Group 1 but had different ovarian gene expression compared to Group 2. These findings suggest that MCP-1 gene knockout could reverse some of the adverse effects of obesity induced by HF diet intake. Future studies assessing ovarian histology in MCP-1 knock out mouse model will confirm our findings. MCP-1 inhibition could represent a future therapeutic target to protect ovarian health from the adverse effects of HF diet ingestion.

Published
2020
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89. Corrigendum to ‘Live birth derived from oocyte spindle transfer to prevent mitochondrial disease’

Author

Zhang, John, primary, Liu, Hui, additional, Luo, Shiyu, additional, Lu, Zhuo, additional, Chávez-Badiola, Alejandro, additional, Liu, Zitao, additional, Yang, Mingxue, additional, Merhi, Zaher, additional, Silber, Sherman J., additional, Munné, Santiago, additional, Konstantinidis, Michalis, additional, Wells, Dagan, additional, Tang, Jian J., additional, and Huang, Taosheng, additional

Published
2017
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92. Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease

Author

Zhang, John, primary, Liu, Hui, additional, Luo, Shiyu, additional, Lu, Zhuo, additional, Chávez-Badiola, Alejandro, additional, Liu, Zitao, additional, Yang, Mingxue, additional, Merhi, Zaher, additional, Silber, Sherman J., additional, Munné, Santiago, additional, Konstandinidis, Michalis, additional, Wells, Dagan, additional, and Huang, Taosheng, additional

Published
2017
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93. Advanced glycation end products: A link between metabolic and endothelial dysfunction in polycystic ovary syndrome?

Author

Pertynska-Marczewska, Magdalena Diamanti-Kandarakis, Evanthia and Zhang, John Merhi, Zaher

Subjects
endocrine system diseases, nutritional and metabolic diseases
Abstract

Polycystic ovary syndrome (PCOS), a heterogeneous syndrome of reproductive and metabolic alterations, is associated with increased long-term risk of cardiovascular complications. This phenomenon has been linked to an increase in oxidative stress and inflammatory markers. Advanced glycation end products (AGEs) are pro-inflammatory molecules that trigger a state of intracellular oxidative stress and inflammation after binding to their cell membrane receptors RAGE. The activation of the AGE RAGE axis has been well known to play a role in atherosclerosis in both men and women. Women with PCOS have systemic chronic inflammatory condition even at the ovarian level as represented by elevated levels of serum/ovarian AGEs and increased expression of the pro-inflammatory RAGE in ovarian tissue. Data also showed the presence of sRAGE in the follicular fluid and its potential protective role against the harmful effect of AGEs on ovarian function. Thus, whether AGE RAGE axis constitutes a link between metabolic and endothelial dysfunction in women with PCOS is addressed in this review. Additionally, we discuss the role of hormonal changes observed in PCOS and how they are linked with the AGE RAGE axis in order to better understand the nature of this complex syndrome whose consequences extend well beyond reproduction. (C) 2015 Elsevier Inc. All rights reserved.

Published
2015

97. Minimal Stimulation IVF vs Conventional IVF

Author

Zhang, John J., primary, Merhi, Zaher, additional, Yang, Mingxue, additional, Bodri, Daniel, additional, Chavez-Badiola, Alejandro, additional, Repping, Sjoerd, additional, and van Wely, Madelon, additional

Published
2016
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