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448 results on '"Minatoguchi S"'

51. 'False-positive' intrathoracic impedance monitor alarm caused by amiodarone-induced hypothyroidism in a patient with cardiac resynchronization therapy-defibrillator

Author

Nakashima, T., primary, Takasugi, N., additional, Kubota, T., additional, Takasugi, M., additional, Kanamori, H., additional, Ushikoshi, H., additional, Hattori, A., additional, Aoyama, T., additional, Kawasaki, M., additional, Nishigaki, K., additional, Takemura, G., additional, and Minatoguchi, S., additional

Published
2011
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54. Should T-wave alternans magnitude be corrected with T-wave amplitude in the ultra-short-term prediction of life-threatening cardiac arrhythmias?

Author

Takasugi, N., primary, Kubota, T., additional, Nishigaki, K., additional, Verrier, R. L., additional, Kawasaki, M., additional, Takasugi, M., additional, Ushikoshi, H., additional, Hattori, A., additional, Ojio, S., additional, Aoyama, T., additional, Takemura, G., additional, and Minatoguchi, S., additional

Published
2011
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55. Relationship between T-wave alternans magnitude and T-wave amplitude before the onset of ventricular tachyarrhythmias during emergent reperfusion in acute coronary syndrome patients

Author

Takasugi, N., primary, Kubota, T., additional, Nishigaki, K., additional, Verrier, R. L., additional, Kawasaki, M., additional, Takasugi, M., additional, Ushikoshi, H., additional, Hattori, A., additional, Ojio, S., additional, Aoyama, T., additional, Takemura, G., additional, and Minatoguchi, S., additional

Published
2011
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57. Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome

Author

Takasugi, N., primary, Kubota, T., additional, Nishigaki, K., additional, Verrier, R. L., additional, Kawasaki, M., additional, Takasugi, M., additional, Ushikoshi, H., additional, Hattori, A., additional, Ojio, S., additional, Aoyama, T., additional, Takemura, G., additional, and Minatoguchi, S., additional

Published
2011
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60. Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair

Author

Kobayashi, H., primary, Minatoguchi, S., additional, Yasuda, S., additional, Bao, N., additional, Kawamura, I., additional, Iwasa, M., additional, Yamaki, T., additional, Sumi, S., additional, Misao, Y., additional, Ushikoshi, H., additional, Nishigaki, K., additional, Takemura, G., additional, Fujiwara, T., additional, Tabata, Y., additional, and Fujiwara, H., additional

Published
2008
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72. The efficacy of prophylactic Shakuyaku-Kanzo-to for myalgia and arthralgia following carboplatin and paclitaxel combination chemotherapy for non-small cell lung cancer.

Author

Yoshida T, Sawa T, Ishiguro T, Horiba A, Minatoguchi S, Fujiwara H, Yoshida, Tsutomu, Sawa, Toshiyuki, Ishiguro, Takashi, Horiba, Akane, Minatoguchi, Shinya, and Fujiwara, Hisayoshi

Abstract

Introduction: To assess the efficacy of Shakuyaku-Kanzo-to, a Japanese herbal medicine, for prophylaxis against paclitaxel-induced myalgia and arthralgia, a comparative study was conducted with 50 patients treated with carboplatin and paclitaxel.Patients and Methods: Patients were alternatively assigned to receive either the intervention group (with Shakuyaku-Kanzo-to) or the control group (without Shakuyaku-Kanzo-to). We assessed the grade and the duration of myalgia and arthralgia.Results: The grades of myalgia and arthralgia in the control group were significantly higher than the grades determined in the intervention group (p = 0.018). The mean duration of myalgia and arthralgia was 2.78 +/- 2.09 days for the intervention group and 5.08 +/- 2.89 days for the control group. The duration was significantly shorter in the intervention group than in the control group (p = 0.002).Discussion: This study shows that prophylactic administration of Shakuyaku-Kanzo-to was effective against paclitaxel-induced myalgia and arthralgia. [ABSTRACT FROM AUTHOR]

Published
2009
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79. Expression of prorenin receptor in renal biopsies from patients with IgA nephropathy

Author

Miyazaki, N., Murata, I., Takemura, G., Hideshi Okada, Kanamori, H., Matsumoto-Miyazaki, J., Yoshida, G., Izumi, K., Kashi, H., Niimi, K., Nishiwaki, A., Miyazaki, T., Ohno, M., Ohashi, H., Suzuki, F., and Minatoguchi, S.

Subjects
Adult, Aged, 80 and over, Male, Vacuolar Proton-Translocating ATPases, Adolescent, Biopsy, Glomerulonephritis, IGA, Receptors, Cell Surface, Middle Aged, Kidney, Fibrosis, Immunohistochemistry, Nephrectomy, Young Adult, Disease Progression, Humans, Original Article, Female, Kidney Diseases, Microscopy, Immunoelectron, Microtubule-Associated Proteins, Aged
Abstract

Prorenin receptor (PRR) has been implicated in the onset and progression of various renal diseases, though its possible association with immunoglobulin A (IgA) nephropathy remains unclear. In the present study, we tried to clarify expression and pathophysiological significance of PRR in IgA nephropathy. We immunohistochemically assessed PRR levels in renal biopsy specimens from 48 patients with IgA nephropathy and evaluated its relevance to the clinical and pathological features of the disease. PRR was detected mainly in renal tubular cells, which was confirmed at the subcellular level using immunoelectron microscopy. The PRR-positive area (%PRR area) correlated with daily urinary protein, which is known to reflect disease severity (r=0.286, P=0.049). PRR levels were weaker in tubular cells bordering areas of severe interstitial fibrosis, where α-smooth muscle actin-positive myofibroblasts were present. We also used immunohistochemical detection of microtubule-associated protein-1 light chain 3 (LC3) and electron microscopy to assess autophagy, a cytoprotective mechanism downstream of PRR. We noted an apparent coincidence between autophagy activation in tubular cells and PRR expression in the same cells. Taken together, our findings suggest that renal expression of PRR in IgA nephropathy may be a compensatory response slowing disease progression by preventing tubular cell death and subsequent fibrosis through activation of cytoprotective autophagic machinery. Further studies using different type of kidney diseases could draw conclusion if the present finding is a generalized observation beyond IgA nephropathy.

81. Poster session 6: Saturday 6 December 2014, 08:30-12:30 * Location: Poster area

Author

Goirigolzarri Artaza, J, Gallego Delgado, M, Jaimes Castellanos, CP, Cavero Gibanel, MA, Pastrana Ledesma, MA, Alonso Pulpon, LA, Gonzalez Mirelis, J, Al Ansi, R Z, Sokolovic, S, Cerin, G, Szychta, W, Popa, B A, Botezatu, D, Benea, D, Manganiello, S, Corlan, A, Jabour, A, Igual Munoz, B, Osaca Asensi, JOA, Andres La Huerta, AALH, Maceira Gonzalez, AMG, Estornell Erill, JEE, Cano Perez, OCP, Sancho-Tello, MJSTDC, Alonso Fernandez, PAF, Sepulveda Sanchez, PSS, Montero Argudo, AMA, Palombo, C, Morizzo, C, Baluci, M, Kozakova, M, Panajotu, A, Karady, J, Szeplaki, G, Horvath, T, Tarnoki, DL, Jermendy, AL, Geller, L, Merkely, B, Maurovich-Horvat, P, Group, MTA-SE "Lendület" Cardiovascular Imaging Research, Moustafa, S, Mookadam, F, Youssef, M, Zuhairy, H, Connelly, M, Prieur, T, Alvarez, N, Ashikhmin, Y, Drapkina, O, Boutsikou, M, Demerouti, E, Leontiadis, E, Petrou, E, Karatasakis, G, Kozakova, M, Morizzo, C, Bianchi, V, Marchi, B, Federico, G, Palombo, C, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Goto, M, Uejima, T, Itatani, K, Pedrizzetti, G, Mada, RO, Daraban, AM, Duchenne, J, Voigt, JU, Chiu, D Y Y, Green, D, Johnstone, L, Sinha, S, Kalra, PA, Abidin, N, Group, Salford Vascular Research, Sikora-Frac, M, Zaborska, B, Maciejewski, P, Bednarz, B, Budaj, A, Nemes, A, Sasi, V, Gavaller, H, Kalapos, A, Domsik, P, Katona, A, Szucsborus, T, Ungi, T, Forster, T, Ungi, I, Pluchinotta, FR, Arcidiacono, C, Saracino, A, Carminati, M, Bussadori, C, Dahlslett, T, Karlsen, S, Grenne, B, Sjoli, B, Bendz, B, Skulstad, H, Smiseth, OA, Edvardsen, T, Brunvand, H, Vereckei, A, Szelenyi, ZS, Szenasi, G, Santoro, C, Galderisi, M, Niglio, T, Santoro, M, Stabile, E, Rapacciuolo, A, Spinelli, L, De Simone, G, Esposito, G, Trimarco, B, Hubert, S, Jacquier, A, Fromonot, J, Resseguier, C, Tessier, A, Guieu, R, Renard, S, Haentjiens, J, Lavoute, C, Habib, G, Menting, M E, Koopman, LP, Mcghie, JS, Rebel, B, Gnanam, D, Helbing, WA, Van Den Bosch, AE, Roos-Hesselink, JW, Shiino, K, Yamada, A, Sugimoto, K, Takada, K, Takakuwa, Y, Miyagi, M, Iwase, M, Ozaki, Y, Placido, R, Ramalho, A, Nobre E Menezes, M, Cortez-Dias, N, Goncalves, S, Guimaraes, T, Robalo Martins, S, Francisco, AR, Almeida, AG, Nunes Diogo, A, Hayashi, T, Itatani, K, Inuzuka, R, Shindo, T, Hirata, Y, Shimizu, N, Miyaji, K, Henri, C, Dulgheru, R, Magne, J, Kou, S, Davin, L, Nchimi, A, Oury, C, Pierard, L, Lancellotti, P, Kovalyova, O, Honchar, O, Tengku, WINDA, Ketaren, ANDRE, Mingo Santos, S, Monivas Palomero, V, Restrepo Cordoba, A, Rodriguez Gonzalez, E, Goirigolzarri Artaza, J, Sayago Silva, I, Garcia Lunar, I, Mitroi, C, Cavero Gibanel, M, Segovia Cubero, J, Ryu, SK, Park, JY, Kim, SH, Choi, JW, Goh, CW, Byun, YS, Choi, JH, Westholm, C, Johnson, J, Jernberg, T, Winter, R, Rio, P, Moura Branco, L, Galrinho, A, Pinto Teixeira, P, Viveiros Monteiro, A, Portugal, G, Pereira-Da-Silva, T, Afonso Nogueira, M, Abreu, J, Cruz Ferreira, R, Mazzone, A, Botto, N, Paradossi, U, Chabane, A, Francini, M, Cerone, E, Baroni, M, Maffei, S, Berti, S, Tatu-Chitoiu, G P, Deleanu, D, Macarie, C, Chioncel, O, Dorobantu, M, Udroiu, C, Calmac, L, Diaconeasa, A, Vintila, V, Vinereanu, D, investigators, RO-STEMI, Ghattas, A, Shantsila, E, Griffiths, H, Lip, GY, Galli, E, Guirette, Y, Daudin, M, Auffret, V, Mabo, P, Donal, E, Fabiani, I, Conte, L, Scatena, C, Barletta, V, Pratali, S, De Martino, A, Bortolotti, U, Naccarato, AG, Di Bello, V, Falanga, G, Alati, E, Di Giannuario, G, Zito, C, Cusma' Piccione, M, Carerj, S, Oreto, G, Dattilo, G, Alfieri, O, La Canna, G, Generati, G, Bandera, F, Pellegrino, M, Alfonzetti, E, Labate, V, Guazzi, M, Cho, EJ, Park, S-J, Lim, HJ, Yoon, HR, Chang, S-A, Lee, S-C, Park, SW, Cengiz, B, Sahin, S T, Yurdakul, S, Kahraman, S, Bozkurt, A, Aytekin, S, Borges, I P, Peixoto, ECS, Peixoto, RTS, Peixoto, RTS, Marcolla, VF, Venkateshvaran, A, Sola, S, Dash, P K, Thapa, P, Manouras, A, Winter, R, Brodin, LA, Govind, S C, Mizariene, V, Verseckaite, R, Bieseviciene, M, Karaliute, R, Jonkaitiene, R, Vaskelyte, J, Arzanauskiene, R, Janenaite, J, Jurkevicius, R, Rosner, S, Orban, M, Nadjiri, J, Lesevic, H, Hadamitzky, M, Sonne, C, Manganaro, R, Carerj, S, Cusma-Piccione, MC, Caprino, A, Boretti, I, Todaro, MC, Falanga, G, Oreto, L, D'angelo, MC, Zito, C, Le Tourneau, T, Cueff, C, Richardson, M, Hossein-Foucher, C, Fayad, G, Roussel, JC, Trochu, JN, Vincentelli, A, Obase, K, Weinert, L, Lang, R, Cavalli, G, Muraru, D, Miglioranza, MH, Addetia, K, Veronesi, F, Cucchini, U, Mihaila, S, Tadic, M, Lang, RM, Badano, L, Polizzi, V, Pino, PG, Luzi, G, Bellavia, D, Fiorilli, R, Chialastri, C, Madeo, A, Malouf, J, Buffa, V, Musumeci, F, Gripari, P, Tamborini, G, Bottari, V, Maffessanti, F, Carminati, C, Muratori, M, Vignati, C, Bartorelli, A, Alamanni, F, Pepi, M, Polymeros, S, Dimopoulos, A, Spargias, K, Karatasakis, G, Athanasopoulos, G, Pavlides, G, Dagres, N, Vavouranakis, E, Stefanadis, C, Cokkinos, DV, Pradel, S, Mohty, D, Magne, J, Darodes, N, Lavergne, D, Damy, T, Beaufort, C, Aboyans, V, Jaccard, A, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Ben Chaabene, A, Kamoun, S, Mrabet, K, Fennira, S, Zargouni, A, Kraiem, S, Jovanova, S, Arnaudova-Dezjulovic, F, Correia, C E, Cruz, I, Marques, N, Fernandes, M, Bento, D, Moreira, D, Lopes, L, Azevedo, O, GROUP, SUNSHINE, Keramida, K, Kouris, N, Kostopoulos, V, Psarrou, G, Giannaris, V, Olympios, CD, Marketou, M, Parthenakis, F, Kalyva, N, Pontikoglou, CH, Maragkoudakis, S, Zacharis, E, Patrianakos, A, Roufas, K, Papadaki, H, Vardas, P, Dominguez Rodriguez, F, Monivas Palomero, V, Mingo Santos, S, Arribas Rivero, B, Cuenca Parra, S, Zegri Reiriz, I, Vazquez Lopez-Ibor, J, Garcia-Pavia, P, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Nemes, A, Domsik, P, Kalapos, A, Forster, T, Serra, W, Lumetti, FL, Mozzani, FM, Del Sante, GDS, Ariani, AA, Corros, C, Colunga, S, Garcia-Campos, A, Diaz, E, Martin, M, Rodriguez-Suarez, ML, Leon, V, Fidalgo, A, Moris, C, De La Hera, JM, Kylmala, M M, Rosengard-Barlund, M, Groop, P H, Lommi, J, Bruin De- Bon, HACM, Bilt Van Der, IA, Wilde, AA, Brink Van Den, RBA, Teske, AJ, Rinkel, GJ, Bouma, BJ, Teixeira, R, Monteiro, R, Garcia, J, Silva, A, Graca, M, Baptista, R, Ribeiro, M, Cardim, N, Goncalves, L, Duszanska, A, Skoczylas, I, Kukulski, T, Polonski, L, Kalarus, Z, Choi, J-H, Park, JS, Ahn, JH, Lee, JW, Ryu, SK, Ahn, J, Kim, DH, Lee, HO, Przewlocka-Kosmala, M, Mlynarczyk, J, Rojek, A, Mysiak, A, Kosmala, W, Pellissier, A, Larochelle, E, Krsticevic, L, Baron, E, Le, V, Roy, A, Deragon, A, Cote, M, Garcia, D, Tournoux, F, Yiangou, K, Azina, C, Yiangou, A, Zitti, M, Ioannides, M, Ricci, F, Dipace, G, Aquilani, R, Radico, F, Cicchitti, V, Bianco, F, Miniero, E, Petrini, F, De Caterina, R, Gallina, S, Jardim Prista Monteiro, R, Teixeira, R, Garcia, J, Baptista, R, Ribeiro, M, Cardim, N, Goncalves, L, Chung, H, Kim, JY, Joung, B, Uhm, JS, Pak, HN, Lee, MH, Lee, KY, Ragab, AM, Abdelwahab, AMIR, Yazeed, YASER, El Naggar, WAEL, Spahiu, K, Spahiu, E, Doko, A, Liesting, C, Brugts, JJ, Kofflard, MJM, Kitzen, JJEM, Boersma, E, Levin, M-D, Coppola, C, Piscopo, G, Rea, D, Maurea, C, Caronna, A, Capasso, I, Maurea, N, Azevedo, O, Tadeu, I, Lourenco, M, Portugues, J, Pereira, V, Lourenco, A, Nesukay, E, Kovalenko, V, Cherniuk, S, Danylenko, O, Muhammedov, MB, Ahmedova, DM, Hojakuliyev, BG, Atayeva, D, Nemes, A, Domsik, P, Kalapos, A, Lengyel, C, Varkonyi, TT, Orosz, A, Forster, T, Castro, M, Abecasis, J, Dores, H, Madeira, S, Horta, E, Ribeiras, R, Canada, M, Andrade, MJ, Mendes, M, Morosin, M, Piazza, R, Leonelli, V, Leiballi, E, Pecoraro, R, Cinello, M, Dell' Angela, L, Cassin, M, Sinagra, G, Nicolosi, GL, Wierzbowska-Drabik, K, Hamala, P, Kasprzak, JD, O'driscoll, J, Rossato, C, Gargallo-Fernandez, P, Araco, M, Sharma, S, Sharma, R, Jakus, N, Baricevic, Z, Ljubas Macek, J, Skoric, B, Skorak, I, Velagic, V, Separovic Hanzevacki, J, Milicic, D, Cikes, M, Deljanin Ilic, M, Ilic, S, Kocic, G, Pavlovic, R, Stoickov, V, Ilic, V, Nikolic, LJ, Generati, G, Bandera, F, Pellegrino, M, Alfonzetti, E, Labate, V, Guazzi, M, Labate, V, Bandera, F, Generati, G, Pellegrino, M, Donghi, V, Alfonzetti, E, Guazzi, M, Zakarkaite, D, Kramena, R, Aidietiene, S, Janusauskas, V, Rucinskas, K, Samalavicius, R, Norkiene, I, Speciali, G, Aidietis, A, Kemaloglu Oz, T, Ozpamuk Karadeniz, F, Akyuz, S, Unal Dayi, S, Esen Zencirci, A, Atasoy, I, Osken, A, Eren, M, Fazendas, P R, Caldeira, D, Stuart, B, Cruz, I, Rocha Lopes, L, Almeida, A R, Sousa, P, Joao, I, Cotrim, C, Pereira, H, Fazendas, P R, Caldeira, D, Stuart, B, Cruz, I, Rocha Lopes, L, Almeida, A R, Joao, I, Cotrim, C, Pereira, H, Sinem Cakal, SC, Elif Eroglu, EE, Baydar, O, Beytullah Cakal, BC, Mehmet Vefik Yazicioglu, MVY, Mustafa Bulut, MB, Cihan Dundar, CD, Kursat Tigen, KT, Birol Ozkan, BO, Ali Metin Esen, A, Yagasaki, H, Kawasaki, M, Tanaka, R, Minatoguchi, S, Houle, H, Warita, S, Ono, K, Noda, T, Watanabe, S, Minatoguchi, S, Cho, E J, Park, S J, Lim, H J, Chang, S A, Lee, S C, Park, S W, Cho, E J, Park, S J, Lim, H J, Chang, S A, Lee, S C, Park, S W, Mornos, C, Cozma, D, Ionac, A, Mornos, A, Popescu, I, Ionescu, G, Pescariu, S, Melzer, L, Faeh-Gunz, A, Seifert, B, Attenhofer Jost, C H, Storve, S, Haugen, BO, Dalen, H, Grue, JF, Samstad, S, Torp, H, Ferrarotti, L, Maggi, E, Piccinino, C, Sola, D, Pastore, F, Marino, PN, Ranjbar, S, Karvandi, M, Hassantash, SA, Karvandi, M, Ranjbar, S, Tierens, S, Remory, I, Bala, G, Gillis, K, Hernot, S, Droogmans, S, Cosyns, B, Lahoutte, T, Tran, N, Poelaert, J, Al-Mallah, M, Alsaileek, A, Nour, K, Celeng, CS, Horvath, T, Kolossvary, M, Karolyi, M, Panajotu, A, Kitslaar, P, Merkely, B, Maurovich Horvat, P, Group, MTA-SE "Lendület" Cardiovascular Imaging Research, Aguiar Rosa, S, Ramos, R, Marques, H, Portugal, G, Pereira Da Silva, T, Rio, P, Afonso Nogueira, M, Viveiros Monteiro, A, Figueiredo, L, and Cruz Ferreira, R

Abstract

Introduction: The increase of left auricular volume (LAV) is a robust cardiovascular event predictor. Despite that echochardiography is more often used, cardiac MRI is considered more accurate. Our objetives are to validate "fast" LAV measures by MRI vs the considered gold standard (GS) and to compare Echo and MRI in a wide spectrum of patients. Methods: In a non-selected popullation with MRI study previously realized, we measured LAV by biplane method (BPMR) and by area-length in 4 chamber view (ALMR) and compared them with biplane (BPe) and discs method (MDDe) in 4 chamber view in echo. To validate MRI measurements, we measured LAV in short axis slices (Simpson Method, SM) in a group of patients and considered it the GS. Results: 186 patients were included (mean age 51 ± 17 age; 123 male; 14 in AF) with clinical indication of cardiac MRI (Philips 1,5 T). In 24 patients SM was calculated. 29% of cardiac MRI were considered normal. Mean underlying pathologies were myocardiopathy (27%), Ischemic myocardiopathy (17%), myopericarditis (10%), prior to AF ablation (4%), valvular disease (6%) and miscellaneous (7%). Excellent correlation was obtained between "fast" MRI measurements and SM in MRI (SM vs BPMR interclass correlation coefficient ICC=0.965 and SM vs ALMR, ICC=0.958; P<0.05) with low interobserver variability (ICC=0.983 for SM; ICC=0.949 for BPMR; ICC=0.931 for ALMR). "Fast" measurements by MRI showed stadistical correlation between them (CCI=0.910) (Figure). Correlation between Echo and MRI measures was only moderate. (BPRM vs BPe CCI=0,469 mean difference -30 ml; ALMR vs MDDe ICC=0,456 mean difference -24 mL). Conclusions: ‘fast’ LAV measures by MRI are comparable with the MRI GS and also between them. Echo values seem to underestimate compared to MRI, so its use may not be suitable.

Published
2014
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82. Poster session 3: Thursday 4 December 2014, 14:00-18:00 * Location: Poster area

Author

Shahgaldi, K, Hegner, T, Da Silva, C, Fukuyama, A, Takeuchi, M, Uema, A, Kado, Y, Nagata, Y, Hayashi, A, Otani, K, Fukuda, S, Yoshitani, H, Otsuji, Y, Morhy, S, Lianza, AC, Afonso, TR, Oliveira, WA, Tavares, GP, Rodrigues, AC, Vieira, MC, Warth, AN, Deutsch, AD, Fischer, CH, Tezynska-Oniszk, I, Turska-Kmiec, A, Kawalec, W, Dangel, J, Maruszewski, B, Bokiniec, R, Burczynski, P, Borszewska-Kornacka, K, Ziolkowska, L, Zuk, M, Mazowsza, eSUM Dzieciaki, Troshina, A, Dzhalilova, DA, Poteshkina, NG, Hamitov, FF, Warita, S, Kawasaki, M, Tanaka, R, Yagasaki, H, Minatoguchi, S, Wanatabe, T, Ono, K, Noda, T, Wanatabe, S, Minatoguchi, S, Angelis, A, Ageli, K, Vlachopoulos, C, Felekos, I, Ioakimidis, N, Aznaouridis, K, Vaina, S, Abdelrasoul, M, Tsiamis, E, Stefanadis, C, Cameli, M, Sparla, S, D'ascenzi, F, Fineschi, M, Favilli, R, Pierli, C, Henein, M, Mondillo, S, Lindqvist, P, Tossavainen, E, Gonzalez, M, Soderberg, S, Henein, M, Holmgren, A, Strachinaru, M, Catez, E, Jousten, I, Pavel, O, Janssen, C, Morissens, M, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Tsai, W-C, Sun, Y-T, Lee, W-H, Yang, L-T, Liu, Y-W, Lee, C-H, Li, W-T, Mizariene, V, Bieseviciene, M, Karaliute, R, Verseckaite, R, Vaskelyte, J, Lesauskaite, V, Chatzistamatiou, E, Mpampatseva Vagena, I, Manakos, K, Moustakas, G, Konstantinidis, D, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Hristova, K, Cornelissen, G, Singh, RB, Shiue, I, Coisne, D, Madjalian, A-M, Tchepkou, C, Raud Raynier, P, Degand, B, Christiaens, L, Baldenhofer, G, Spethmann, S, Dreger, H, Sanad, W, Baumann, G, Stangl, K, Stangl, V, Knebel, F, Azzaz, S, Kacem, S, Ouali, S, Risos, L, Dedobbeleer, C, Unger, P, Sinem Cakal, SC, Elif Eroglu, EE, Baydar, O, Beytullah Cakal, BC, Mehmet Vefik Yazicioglu, MVY, Mustafa Bulut, MB, Cihan Dundar, CD, Kursat Tigen, KT, Birol Ozkan, BO, Ali Metin Esen, AME, Tournoux, F, Chequer, R, 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Cruz, I, Pereira, V, Marques, N, Biering-Sorensen, T, Mogelvang, R, Schnohr, P, Jensen, JS, Chatzistamatiou, E, Konstantinidis, D, Manakos, K, Mpampatseva Vagena, I, Moustakas, G, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Cho, EJ, Kim, JJ, Hwang, BH, Kim, DB, Jang, SW, Jeon, HK, Cho, JS, Chatzistamatiou, E, Konstantinidis, D, Memo, G, Mpapatzeva Vagena, I, Moustakas, G, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Jedrzejewska, I, Konopka, M, Krol, W, Swiatowiec, A, Dluzniewski, M, Braksator, W, Sefri Noventi, S, Sugiri, S, Uddin, I, Herminingsih, S, Arif Nugroho, M, Boedijitno, S, Caro Codon, J, Blazquez Bermejo, Z, Valbuena Lopez, S C, Lopez Fernandez, T, Rodriguez Fraga, O, Torrente Regidor, M, Pena Conde, L, Moreno Yanguela, M, Buno Soto, A, Lopez-Sendon, J L, Stevanovic, A, Dekleva, M, Kim, MN, Kim, SA, Kim, YH, Shim, JM, Park, SM, Park, SW, Kim, YH, Shim, WJ, Kozakova, M, Muscelli, E, Morizzo, C, Casolaro, A, Paterni, M, Palombo, C, Bayat, 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Shin, S, Shim, CY, Hong, GR, and Chung, N

Abstract

Objective:  We aimed to investigate the reproducibility of vena contracta (VC) in mitral regurgitation (MR) of different etiology between an inexperienced and an experienced echocardiographer. Background: MR is the second most common valvular heart disease in Europe that requires surgery.  Echocardiography is the principal modality of investigation when MR is suspected. In European and American guidelines VC is described as one of the most feasible echocardiographic measurements in the assessment of MR. There is a lack of publications regarding intra-observer variability and studies comparing inexperienced and experienced echocardiographers for the assessment of VC. Method/Material: VC of 55 recorded 2D echocardiograms with known MR of different degree and etiology were analyzed from parasternal long axis view, 4- and 3 chamber view. The mean value of the different plane measurements of each exam was used for statistical analysis. Analyses were made by an inexperienced (A) fellow echocardiographer (<100 studies) and a level 3 experienced (B) echocardiographer. Measurements of VC by the 2 echocardiographers were performed blinded to clinical data. Measurements were performed with at least 2 weeks apart, blinded to the first measurement. Results: Three exams were excluded (feasibility 95%) from statistical analysis because adequate color Doppler images from all tree planes was not available. The inter class correlation (ICC) between the first and second analysis was (r=0.75; 95% CI -1.1 to 1.7mm) for A and (r=0.94; 95% CI -0.76 to 0.84mm) for B. There was good ICC between the 2 echocardiographers (r=0.78; 95% CI -1.5 to 1.3mm). The intra observer variability was 11.1% for A and 6.1% for B. The inter observer variability was 11.7% (p>0.05 for all). Conclusion: Measurement of vena contracta in mitral regurgitation is a feasible semi-quantitative parameter. Good correlation and narrow limits of agreement between a novice and an experienced echocardiographer was demonstrated in our study.

Published
2014
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83. Motion of left atrial appendage as a determinant of thrombus formation in patients with a low CHADS2 score receiving warfarin for persistent nonvalvular atrial fibrillation

Author

Ono Koji, Iwama Makoto, Kawasaki Masanori, Tanaka Ryuhei, Watanabe Takatomo, Onishi Noriyuki, Warita Shunichiro, Kojima Tai, Kato Takashi, Goto Yoshiaki, Arai Masazumi, Nishigaki Kazuhiko, Takemura Genzou, Noda Toshiyuki, Watanabe Sachiro, and Minatoguchi Shinya

Subjects
Atrial fibrillation, Left atrial appendage, Thrombus, Transesophageal echocardiography, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background The aim of this study was to define the independent determinants of left atrial appendage (LAA) thrombus among various echocardiographic parameters measured by Velocity Vector Imaging (VVI) in patients with nonvalvular atrial fibrillation (AF) receiving warfarin, particularly in patients with a low CHADS2 score. Methods LAA emptying fraction (EF) and LAA peak longitudinal strain were measured by VVI using transesophageal echocardiography in 260 consecutive patients with nonvalvular persistent AF receiving warfarin. The patients were divided into two groups according to the presence (n=43) or absence (n=217) of LAA thrombus. Moreover, the patients within each group were further divided into subgroups according to a CHADS2 score ≤1. Results Multivariate logistic regression analysis showed that LAAEF was an independent determinant of LAA thrombus in the subgroup of 140 with a low CHADS2 score. Receiver operating characteristics curve analysis showed that an LAAEF of 21% was the optimal cutoff value for predicting LAA thrombus. Conclusions LAA thrombus formation depended on LAA contractility. AF patients with reduced LAA contractile fraction (LAAEF ≤21%) require strong anticoagulant therapy to avoid thromboembolic events regardless of a low CHADS2 score (≤1).

Published
2012
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84. Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques

Author

Yamaki Takahiko, Kawasaki Masanori, Jang Ik-Kyung, Raffel Owen, Ishihara Yoshiyuki, Okubo Munenori, Kubota Tomoki, Hattori Arihiro, Nishigaki Kazuhiko, Takemura Genzou, Fujiwara Hisayoshi, and Minatoguchi Shinya

Subjects
Computed tomography, Integrated backscatter, Intravascular ultrasound, Coronary plaque, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background The purpose of this study was to determine the cut-off values of Hounsfield units (HU) for the discrimination of plaque components and to evaluate the feasibility of measurement of the volume of plaque components using multi-detector row computed tomography (MDCT). Methods Coronary lesions (125 lesions in 125 patients) were visualized by both integrated backscatter intravascular ultrasound (IB-IVUS) and 64-slice MDCT at the same site. The IB values were used as a gold standard to determine the cut off values of HU for the discrimination of plaque components. Results Plaques were classified as lipid pool (n =50), fibrosis (n =65) or calcification (n =35) by IB-IVUS. The HU of lipid pool, fibrosis and calcification were 18 ± 18 HU (−19 to 58 HU), 95 ± 24 HU (46 to 154 HU) and 378 ± 99 HU (188 to 605 HU), respectively. Using receiver operating characteristic curve analysis, a threshold of 50 HU was the optimal cutoff values to discriminate lipid pool from fibrosis. Lipid volume measured by MDCT was correlated with that measured by IB-IVUS (r =0.66, p Conclusion Lipid volume measured by MDCT was moderately correlated with that measured by IB-IVUS. MDCT may be useful for volumetric assessment of the lipid volume of coronary plaques, whereas the assessment of fibrosis volume was unstable.

Published
2012
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85. Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound

Author

Ishihara Yoshiyuki, Kawasaki Masanori, Hattori Arihiro, Imai Hajime, Takahashi Shigekiyo, Sato Hironobu, Kubota Tomoki, Okubo Munenori, Ojio Shinsuke, Nishigaki Kazuhiko, Takemura Genzou, Fujiwara Hisayoshi, and Minatoguchi Shinya

Subjects
Coronary artery disease, Intravascular ultrasound, Plaque, Stiffness, Tissue, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background The purpose of the present study was to evaluate the mechanical properties of coronary plaques and plaque behavior, and to elucidate the relationship among tissue characteristics of coronary plaques, mechanical properties and coronary risk factors using integrated backscatter intravascular ultrasound (IB-IVUS). Methods Non-targeted plaques with moderate stenosis (plaque burden at the minimal lumen site: 50-70%) located proximal to the site of the percutaneous coronary intervention target lesions were evaluated by IB-IVUS. Thirty-six plaques (less calcified group: an arc of calcification ≤10°) in 36 patients and 22 plaques (moderately calcified group: 10° Results In the less calcified group, there was a significant correlation between EEMV compliance and the relative lipid volume (r = 0.456, p = 0.005). There was a significant inverse correlation between EEM area stiffness index and the relative lipid volume (p = 0.032, r = −0.358). The LV compliance and EEM area stiffness index were significantly different in the diabetes mellitus (DM) group than in the non-DM group (1.32 ± 1.49 vs. 2.47 ± 1.79%/10 mmHg, p =0.014 and 28.3 ± 26.0 vs. 15.7 ± 17.2, p =0.020). The EEMV compliance and EEM area stiffness index were significantly different in the hypertension (HTN) group than in the non-HTN group (0.77 ± 0.68 vs. 1.57 ± 0.95%/10 mmHg, p =0.012 and 26.5 ± 24.3 vs. 13.0 ± 16.7, p =0.020). These relationships were not seen in the moderately calcified group. Conclusion The present study provided new findings that there was a significant correlation between mechanical properties and tissue characteristics of coronary arteries. In addition, our results suggested that the EEMV compliance and the LV compliance were independent and the compliance was significantly impaired in the patients with DM and/or HTN. Assessment of coronary mechanical properties during PCI may provide us with useful information regarding the risk stratification of patients with coronary heart disease.

Published
2012
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86. Left atrial pathological degeneration assessed by integrated backscatter transesophageal echocardiography as a predictor of progression to persistent atrial fibrillation: Results from a prospective study of three-years follow-up

Author

Kubota Tomoki, Kawasaki Masanori, Takasugi Nobuhiro, Imai Hajime, Ishihara Yoshiyuki, Okubo Munenori, Takahashi Shigekiyo, Sato Hironobu, Nishigaki Kazuhiko, Takemura Genzou, and Minatoguchi Shinya

Subjects
Atrial fibrillation, Tissue characterization, Transesophageal echocardiography, Integrated backscatter, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background It is recognized that one of the causes of atrial fibrillation (AF) is pathological degeneration of the left atrium (LA). However, prospective study that elucidated the relationship between the incidence of persistent AF and pathological degeneration has not been performed. The purpose of this study was to elucidate the usefulness of integrated backscatter (IBS) values for the prediction of progression from paroxysmal AF (PAF) to persistent AF. Methods We measured IBS values of the entire LA wall at 5 mm intervals (except the posterior wall) in 27 patients with paroxysmal AF and evaluated progression to persistent AF for three years. IBS values were acquired with transesophageal echocardiography (TEE) using a 4–7 MHz transducer. IBS values were calculated as the average power of the backscattered signal from regions of interest (ROI). Each IBS value was color-coded to construct three dimensional maps. Results Average IBS values of total voxels in color-coded maps in the persistent AF group were significantly greater than those in the non-persistent AF group (25.8 ± 5.0 dB vs. 17.4 ± 10.2 dB, p = 0.047), whereas there was no significant difference in LA diameter between the persistent AF and the non-persistent AF group. There was significant difference in persistent AF-free survival after the baseline measurements in the subjects stratified by IBS value ( Conclusion Using IBS values measured by TEE, we can identify an increase in atrial degeneration that may predict the occurrence of persistent AF before LA dilation.

Published
2012
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87. Poster session 5: Friday 5 December 2014, 14:00-18:00 * Location: Poster area

Author

Turco, A, Duchenne, J, Nuyts, J, Gheysens, O, Voigt, J-U, Claus, P, Vunckx, K, Muhtarov, K, Ozer, N, Turk, G, Sunman, H, Karakulak, U, Sahiner, L, Kaya, B, Yorgun, H, Hazirolan, T, Aytemir, K, Warita, S, Kawasaki, M, Tanaka, R, Houle, H, Yagasaki, H, Nagaya, M, Ono, K, Noda, T, Watanabe, S, Minatoguchi, S, Kyle, AS, Dauphin, C, Lusson, J R, Dragoi Galrinho, R, Rimbas, RC, Ciobanu, AO, Marinescu, B, Cinteza, M, Vinereanu, D, 28343/04.11.2013, number, Medicine, Funding Authority: University of, Davila, Pharmacy Carol, "Young Researchers" Projects – 2013, Buchar, Dragoi Galrinho, R, Ciobanu, AO, Rimbas, RC, Marinescu, B, Cinteza, M, Vinereanu, D, 159/1.5/S/138907, Grant POSDRU, Aparina, O, Stukalova, O, Butorova, E, Makeev, M, Bolotova, M, Parkhomenko, D, Golitsyn, SP, Zengin, E, Hoffmann, B A, Ramuschkat, M, Ojeda, F, Weiss, C, Willems, S, Blankenberg, S, Schnabel, R B, Sinning, C R, Schubert, U, Suhai, F I, Toth, A, Kecskes, K, Czimbalmos, CS, Csecs, I, Maurovich-Horvat, P, Simor, T, Merkely, B, Vago, H, Slawek, D, Chrzanowski, L, Krecki, R, Binkowska, A, Kasprzak, J D, Palombo, C, Morizzo, C, Kozakova, M, Biering-Sorensen, T, Mogelvang, R, Jensen, JS, Charisopoulou, DC, Koulaouzidis, GK, Rydberg, AR, Henein, MH, Kovacs, A, Olah, A, Lux, A, Matyas, C, Nemeth, BT, Kellermayer, D, Ruppert, M, Birtalan, E, Merkely, B, Radovits, T, Sengelov, M, Biering-Sorensen, T, Jorgensen, PG, Bruun, NE, Fritz-Hansen, T, Bech, J, Olsen, FJ, Sivertsen, J, Jensen, JS, Henri, C, Dulgheru, R, Magne, J, Kou, S, Davin, L, Nchimi, A, Oury, C, Pierard, L, Lancellotti, P, Sahin, S T, Cengiz, B, Yurdakul, S, Altuntas, E, Aytekin, V, Aytekin, S, Bajraktari, G, Ibrahimi, P, Bytyci, I, Ahmeti, A, Batalli, A, Elezi, S, Henein, MY, Pavlyukova, EN, Tereshenkova, EK, Karpov, RS, Barbier, P, Mirea, O, Guglielmo, M, Savioli, G, Cefalu, C, Maltagliati, MC, Tumasyan, LR, Adamyan, KG, Chilingaryan, AL, Tunyan, LG, Kowalik, E, Klisiewicz, A, Biernacka, EK, Hoffman, P, Park, CS, Yi, JEY, Cho, JSC, Ihm, SHI, Kim, HYK, Cho, EJC, Jeon, HKJ, Jung, HOJ, Youn, HJY, Mcghie, JS, Menting, ME, Vletter, WB, Roos-Hesselink, JW, Geleijnse, ML, Van Der Zwaan, H, Van Den Bosch, A, Spethmann, S, Baldenhofer, G, Stangl, V, Baumann, G, Stangl, K, Laule, M, Dreger, H, Knebel, F, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, AG, Cardiff, Investigators, MEDIA, Keramida, K, Kouris, N, Kostopoulos, V, Kostakou, P, Petrogiannos, CH, Olympios, CD, Bajraktari, G, Berisha, G, Bytyci, I, Ibrahimi, P, Rexhepaj, N, Henein, MY, Wdowiak-Okrojek, K, Shim, A, Wejner-Mik, P, Szymczyk, E, Michalski, B, Kasprzak, JD, Lipiec, P, Tarr, A, Stoebe, S, Pfeiffer, D, Hagendorff, A, Haykal, M, Ryu, SK, Park, JY, Kim, SH, Choi, JW, Goh, CW, Byun, YS, Choi, JH, Sonoko, M, Onishi, T, Fujimoto, W, Yamada, S, Taniguchi, Y, Yasaka, Y, Kawai, H, Okura, H, Sakamoto, Y, Murata, E, Kanai, M, Kataoka, T, Kimura, T, Watanabe, N, Kuriyama, N, Nakama, T, Furugen, M, Sagara, S, Koiwaya, H, Ashikaga, K, Matsuyama, A, Shibata, Y, Meimoun, P, Abouth, S, Martis, S, Boulanger, J, Elmkies, F, Zemir, H, Tzvetkov, B, Luycx-Bore, A, Clerc, J, Galli, E, Oger, E, Guirette, Y, Daudin, M, Fournet, M, Donal, E, Galli, E, Guirette, Y, Mabo, P, Donal, E, Keramida, K, Kouris, N, Kostopoulos, V, Psarrou, G, Petrogiannos, CH, Hatzigiannis, P, Olympios, CD, Igual Munoz, B, Erdociain Perales, MEP, Maceira Gonzalez Alicia, AMG, Vazquez Sanchez, ALEJAN, Miro Palau, VMP, Alonso Fernandez, PAF, Donate Bertolin, LDB, Estornell Erill, JEE, Cervera, AC, Montero Argudo Anastasio, AMA, Okura, H, Koyama, T, Maehama, T, Imai, K, Yamada, R, Kume, T, Neishi, Y, Caballero Jimenez, L, Garcia-Navarro, M, Saura, D, Oliva, MJ, Gonzalez-Carrillo, J, Espinosa, MD, Valdes, M, De La Morena, G, Venkateshvaran, A, Sola, S, Dash, P K, Annappa, C, Manouras, A, Winter, R, Brodin, LA, Govind, S C, Laufer-Perl, LM, Topilsky, Y, Stugaard, M, Koriyama, H, Katsuki, K, Masuda, K, Asanuma, T, Takeda, Y, Sakata, Y, Nakatani, S, Marta, L, Abecasis, J, Reis, C, Dores, H, Cafe, H, Ribeiras, R, Andrade, MJ, Mendes, M, Goebel, B, Hamadanchi, A, Schmidt-Winter, C, Otto, S, Jung, C, Figulla, HR, Poerner, TC, Kim, D-H, Sun, BJ, Jang, JY, Choi, HN, Song, J-M, Kang, D-H, Song, J-K, Zakhama, L, Slama, I, Boussabah, E, Antit, S, Herbegue, B, Annabi, MS, Jalled, A, Ben Ameur, W, Thameur, M, Ben Youssef, S, O' Grady, H, Gilmore, M, Delassus, P, Sturmberger, T, Ebner, C, Aichinger, J, Tkalec, W, Eder, V, Nesser, HJ, Caggegi, A M, Scandura, S, Capranzano, P, Grasso, C, Mangiafico, S, Ronsivalle, G, Dipasqua, F, Arcidiacono, A, Cannata, S, Tamburino, C, Chapman, M, Henthorn, RENEE, Surikow, S, Zoontjens, J, Stocker, B, Mclean, T, Zeitz, C J, Fabregat Andres, O, Estornell-Erill, J, Ridocci-Soriano, F, De La Espriella, R, Albiach-Montanana, C, Trejo-Velasco, B, Perdomo-Londono, D, Facila, L, Morell, S, Cortijo-Gimeno, J, Kouris, N, Keramida, K, Kostopoulos, V, Psarrou, G, Kostakou, P, Olympios, CD, Kuperstein, R, Blechman, I, Freimatk, D, Arad, M, Ochoa, J P, Fernandez, A, Vaisbuj, F, Salmo, F, Fava, AM, Casabe, H, Guevara, EG, Fernandes, A, Cateano, F, Almeida, I, Silva, J, Trigo, J, Botelho, A, Sanches, C, Venancio, M, Goncalves, L, Schnell, F, Daudin, M, Oger, E, Bouillet, P, Mabo, P, Carre, F, Donal, E, Petrella, L, Fabiani, D, Paparoni, S, De Remigis, F, Tomassoni, G, Prosperi, F, Napoletano, C, Marchel, M, Serafin, A, Kochanowski, J, Steckiewicz, R, Madej-Pilarczyk, A, Filipiak, KJ, Opolski, G, Abid, L, Ben Kahla, S, Charfeddine, S, Kammoun, S, Monivas Palomero, V, Mingo Santos, S, Goirigoizarri Artaza, J, Rodriguez Gonzalez, E, Restrepo Cordoba, A, Rivero Arribas, B, Garcia Lunar, I, Gomez Bueno, M, Sayago Silva, I, Segovia Cubero, J, Zengin, E, Radunski, U K, Klusmeier, M, Ojeda, F, Rybczynski, M, Barten, M, Muellerleile, K, Reichenspurner, H, Blankenberg, S, Sinning, C R, Romano, G, Licata, P, Tuzzolino, F, Clemenza, F, Di Gesaro, G, Hernandez Baravoglia, C, Scardulla, C, Pilato, M, Hashimoto, G, Suzuki, M, Yoshikawa, H, Otsuka, T, Isekame, Y, Iijima, R, Hara, H, Nakamura, M, Sugi, K, Melnikova, MA, Krestjyaninov, MV, Ruzov, VI, Magnino, C, Omede', P, Avenatti, E, Presutti, D, Moretti, C, Ravera, A, Sabia, L, Gaita, F, Veglio, F, Milan, A, Magda, SL, Mincu, RI, Soare, A, Mihai, CM, Florescu, M, Mihalcea, D, Cinteza, M, Vinereanu, D, POSDRU/159/1.5/S/141531, Grant, 112/2011, grant CNCSIS, Chatzistamatiou, E, Mpampatseva Vagena, I, Manakos, K, Moustakas, G, Konstantinidis, D, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Petroni, R, Acitelli, A, Cicconetti, M, Di Mauro, M, Altorio, SF, Romano, S, Petroni, A, Penco, M, Apostolovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Salinger-Martinovic, S, Pavlovic, M, Djordjevic-Radojkovic, D, Tahirovic, E, Dungen, HD, ELD, CIBIS, Jung, I H, Byun, Y S, Goh, C W, Kim, B O, Rhee, K J, Lee, D S, Kim, M J, Seo, H S, Kim, H Y, Tsverava, M, Tsverava, D, Zaletova, T, Shamsheva, D, Parkhomenko, O, Bogdanov, A, Derbeneva, S, Leotescu, A, Tudor, I, Gurghean, A, Bruckner, I, Plaskota, KJ, Trojnarska, O, Bartczak, A, Grajek, S, Sharma, P, Sharma, D, Garg, S, Vazquez Lopez-Ibor, J, Monivas Palomero, V, Solano-Lopez, JM, Zegri Reiriz, I, Dominguez Rodriguez, F, Gonzalez Mirelis, J, Mingo Santos, S, Sayago, I, Garcia Pavia, P, Segovia Cubero, J, Konecny, T, Noseworthy, P, Kapa, S, Cooper, LT, Mulpuru, SK, Asirvatham, S, Florescu, M, Mihalcea, D, Magda, S, Radu, E, Chirca, A, Acasandrei, AM, Jinga, D, Mincu, R, Enescu, OA, Vinereanu, D, 112/2011, no., PN-II-ID-PCE-2011-3-0791, Saura Espin, D, Caballero Jimenez, L, Oliva Sandoval, MJ, Gonzalez Carrillo, J, Garcia Navarro, M, Espinosa Garcia, MD, Valdes Chavarri, M, De La Morena Valenzuela, G, Abul Fadl, AAM, Mourad, MM, team, Primary care Echocardiography, Campanale, C M, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, Pardo Gonzalez, L, Delgado, M, Ruiz, M, Rodriguez, S, Hidalgo, F, Ortega, R, Mesa, D, Suarez De Lezo Cruz Conde, J, Bengrid, T M, Zhao, Y, Henein, MY, Kenjaev, S, Alavi, AL, Kenjaev, ML, Mendes, LM, Lima, S, Dantas, C, Melo, I, Madeira, V, Balao, S, Alves, H, Baptista, E, Mendes, P, Santos, JF, Scali, MC, Mandoli, GE, Simioniuc, A, Massaro, F, Di Bello, V, Marzilli, M, Dini, FL, Cifra, B, Dragulescu, A, Friedberg, MK, Mertens, L, Scali, MC, Bayramoglu, A, Tasolar, H, Otlu, YO, Hidayet, S, Kurt, F, Dogan, A, Pekdemir, H, Stefani, L, Galanti, GG, De Luca, ADL, Toncelli, LT, Pedrizzetti, GP, Gopal, A S, Saha, SK, Toole, RS, Kiotsekoglou, A, Cao, JJ, Reichek, N, Ho, S-J, Hung, S-C, Chang, F-Y, Liao, J-N, Niu, D-M, Yu, W-C, Nemes, A, Kalapos, A, Domsik, P, Forster, T, Siarkos, M, Sammut, E, Lee, L, Jackson, T, Carr-White, G, Rajani, R, Kapetanakis, S, Jarvinen, VM, Sipola, P, Madeo, A, Piras, P, Evangelista, A, Giura, G, Dominici, T, Nardinocchi, P, Varano, V, Chialastri, C, Puddu, PE, Torromeo, C, Sanchis Ruiz, L, Montserrat, S, Obach, V, Cervera, A, Bijnens, B, Sitges, M, Charisopoulou, D, Banner, N R, Rahman-Haley, S, Kim, BJ, Kang, JG, Lee, SH, Sung, KC, Kim, BS, Kang, JH, Lee, ES, Imperadore, F, Del Greco, M, Jermendy, AL, Horcsik, DV, Horvath, T, Celeng, C, Nagy, E, Bartykowszki, A, Tarnoki, DL, Merkely, B, Maurovich-Horvat, P, Jermendy, G, Whitaker, J, Demir, OM, Walton, J, Wragg, A, Alfakih, K, Karolyi, M, Szilveszter, B, Raaijmakers, R, Giepmans, W, Horvath, T, Merkely, B, Maurovich-Horvat, P, Koulaouzidis, GK, Charisopoulou, DC, Mcarthur, TM, Jenkins, PJJ, Henein, MH, Silva, T, Ramos, R, Oliveira, M, Marques, H, Cunha, P, Silva, MN, Barbosa, C, Sofia, A, Pimenta, R, Ferreira, RC, Al-Mallah, M, and Alsaileek, A

Abstract

Clinical PET acquisitions of the heart suffer from artefacts and drops in image quality due to the poor spatial resolution of the PET system. Moreover, cardiac PET images are further degraded by the blur caused by the breathing and beating motions, thus hampering diagnosis and evaluation of myocardial pathologies. Anatomy-enhanced PET reconstruction, using a high-resolution CT, has proven useful in brain imaging. In cardiac datasets however, due to the motion artefacts, the application of any restoring technique on datasets affected by motion blur needs to be preceded by the validation of the proposed method on realistic static datasets. In this work, the validation is performed using static cardiac ex vivo datasets obtained from a number of sacrificed sheep, scanned on a clinical PET/CT scanner. The aim of this work is to assess the effectiveness of reconstructions of the acquired datasets with different CT-based anatomical priors, in comparison to reconstructions currently applied in clinical practise. The gold standard to which all reconstructions are compared consists of images of the same hearts scanned on a small-animal PET scanner, whose high spatial resolution allows for almost artefact-free images. Encouraging results were obtained so far, with improvements in volume delineation and uniformity of activity values when anatomical information was used. Fig 1 shows the gold standard image (left) compared to a regular clinical reconstruction (middle) and to a reconstruction using the high-resolution CT as anatomical information (right). Figure

Published
2014
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88. Modulation of Norepinephrine Release in AdriamycinInduced Heart Failure in Rabbits

Author

Minatoguchi, S. and Majewski, H.

Abstract

In congestive heart failure CHF, sympathetic neurotransmitter release is enhanced. We investigated the possibility that this is due in part to alterations in activation of either releaseinhibiting 2adrenoceptors or releaseenhancing angiotensin II AII receptors at postganglionic sympathetic nerve endings. CHF was induced in rabbits by adriamycin 1 mgkg intravenously i.v., twice weekly for 8 weeks and was characterized by reduced cardiac output CO and enhanced norepinephrine NE release rate in pentobarbitalanesthetized rabbits. After pithing and stimulation of the spinal sympathetic outflow, there was no difference in NE release rate between the two groups, suggesting that the enhanced NE release rate observed in adriamycintreated anesthetized rabbits was of central origin. The 2adrenoceptorblocking drug yohimbine 1 mgkg, i.v. enhanced NE release rate, which is an indication of feedback inhibition of NE release through presynaptic 2adrenoceptors. In anesthetized rabbits, this effect of yohimbine was greater in adriamycintreated than in vehicletreated animals. However, in pithed rabbits with electrically stimulated sympathetic outflow, there was no difference in the facilitative effect of yohimbine between the two groups, suggesting that inhibitory presynaptic 2adrenoceptors are activated to a greater extent in heart failure due to the increased transmitter release. Removing inhibitory 2adrenoceptor input has a functional consequence in that yohimbine increased heart rate HR in adriamycintreated but not in vehicletreated anesthetized rabbits. Captopril 1 mgkg, i.v. decreased NE release rate in pithed rabbits with stimulated sympathetic outflow but had no effect on NE release rate in anesthetized rabbits. However, since equihypotensive infusion of sodium nitroprusside SNP 7 gkgmin i.v. enhanced NE release rate in anesthetized rabbits, this reflex effect indicates that captopril induced a relative reduction in NE release. These effects of captopril are an indication of endogenous AII facilitation of NE release, and this was not different in adriamycintreated animals. Our results suggest that in adriamycininduced heart failure in rabbits the enhanced sympathetic transmitter release is substantially buffered by the presynaptic 2adrenoceptor mechanism, which serves to protect organs such as heart from excess sympathetic stimulation. The vasoconstrictor and neuronal effects of AII appear to be unchanged in this model.

Published
1994

91. Elevated plasma progranulin levels in the acute phase are correlated with recovery of left ventricular function in the chronic phase in patients with acute myocardial infarction.

Author

Minatoguchi S, Satake A, Murase H, Yoshizumi R, Komaki H, Baba S, Yasuda S, Ojio S, Tanaka T, Okura H, and Minatoguchi S

Subjects
Humans, Male, Female, Middle Aged, Aged, Intercellular Signaling Peptides and Proteins blood, Recovery of Function, Echocardiography, Biomarkers blood, Case-Control Studies, Progranulins blood, Myocardial Infarction blood, Myocardial Infarction physiopathology, Ventricular Function, Left physiology
Abstract

Background: Progranulin is a secreted glycoprotein that regulates inflammation and wound healing. However, plasma progranulin levels in the acute phase and their clinical significance in patients with acute myocardial infarction (AMI) remain to be elucidated., Objective: We aimed to investigate the relationship between the increase in plasma progranulin levels in the acute phase and the recovery of left ventricular function in the chronic phase in AMI patients., Method and Result: Eighteen AMI patients were followed up for 6 months. Blood samples were collected from the antecubital vein on day 0 (on admission) and day 7 in the acute phase. The control group consisted of patients without significant coronary artery stenosis, as assessed by cardiac catheterization (n = 16). Plasma progranulin levels were measured by enzyme-linked immunosorbent assay. Echocardiography was performed in the acute (within 7 days) and chronic (6 months) phases of AMI to evaluate left ventricular ejection fraction using the modified Simpson's method. Plasma progranulin levels in the AMI group on day 0 (69.5 ± 24.6 ng/mL) were similar to those in the control group (84.2 ± 47.1 ng/mL). There was a significant increase in progranulin levels in the AMI group on day 7 (104.2 ± 52.0 ng/mL) compared with day 0. The increase in plasma progranulin levels in the acute phase was positively correlated with the increase in left ventricular ejection fraction between the acute and chronic phases. Among various factors, only plasma progranulin levels were favorably correlated with left ventricular functional recovery in the chronic phase., Conclusion: The increase in plasma progranulin levels in the acute phase may serve as a predictive biomarker and a contributer for the recovery of left ventricular function in the chronic phase in patients with AMI., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Minatoguchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2024
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92. Rotational, orbital atherectomy and intravascular lithotripsy for coronary calcified nodules: insights from optical coherence tomography.

Author

Yasumura K, Koshy AN, Vinayak M, Vengrenyuk Y, Minatoguchi S, Krishnamoorthy P, Hooda A, Sharma R, Kapur V, Sweeny J, Sharma SK, and Kini AS

Abstract

Background: The optimal treatment strategy for coronary calcified nodules (CN) remains uncertain. We aimed to evaluate the efficacy and safety of different calcium modification strategies, including rotational atherectomy (RA), orbital atherectomy (OA), and intravascular lithotripsy (IVL) for managing CN with optical coherence tomography (OCT) guidance., Methods: Consecutive patients undergoing OCT-guided percutaneous coronary intervention (PCI) for severely calcified lesions using RA, OA, or IVL between January 2017 and December 2022 were included. Primary endpoint was minimum stent area (MSA) post-PCI. Secondary endpoints included MSA at CN site and 1-year target vessel failure (TVF), defined as a composite of cardiac death, target-vessel myocardial infarction, or target vessel revascularization., Results: Among 154 patients and 158 lesions, CN was identified in 54 lesions (34.2%) and managed with RA (39%, n = 21), OA (33%, n = 18), or IVL (28%, n = 15). The IVL group exhibited a larger minimal lumen diameter, maximum calcium arc, and maximum calcium thickness. Post-PCI OCT demonstrated comparable MSA (RA: 6.23 ± 0.34 mm², OA: 5.75 ± 0.39 mm², IVL: 6.24 ± 0.46 mm²; p = 0.62) and MSA at CN site (7.17 ± 0.43 mm², 6.46 ± 0.49 mm², 7.86 ± 0.56 mm², respectively; p = 0.55) after adjusting for morphologic factors. The incidence of TVF at 1 year was similar among the group (RA: 19.0%, OA: 22.2%, IVL: 13.3%, p = 0.81)., Conclusions: In patients undergoing PCI for CN, similar procedural and clinical outcomes can be achieved using RA, OA, or IVL. These findings warrant further investigation in larger, prospective trials., (© 2024 Wiley Periodicals LLC.)

Published
2024
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93. Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction.

Author

Murase H, Minatoguchi S, Heishima K, Yasuda S, Satake A, Yoshizumi R, Komaki H, Baba S, Ojio S, Tanaka T, Akao Y, Minatoguchi S, and Okura H

Subjects
Humans, Male, Female, Aged, Middle Aged, Case-Control Studies, MicroRNAs blood, Ventricular Dysfunction, Left blood, Ventricular Dysfunction, Left physiopathology, Ventricular Dysfunction, Left diagnosis, Ventricular Dysfunction, Left genetics, Ventricular Function, Left physiology, Biomarkers blood, Stroke Volume physiology, Echocardiography
Abstract

MicroRNA(miR)-143 and miR-145 are mainly expressed in vascular smooth muscle cells. However, the relationship between plasma miR-143 or miR-145 levels and the left ventricular (LV) function in patients with heart diseases remains unclear. Blood samples were taken from the antecubital vein in patients with heart diseases (n = 52), such as coronary artery disease, old myocardial infarction, cardiomyopathy, and valvular heart disease, and controls without heart diseases (n = 22). We measured plasma miR-143 and -145 levels by quantitative RT-PCR using TaqMan MicroRNA Assays and THUNDERBIRD Probe qPCR Mix. Plasma BNP levels were also measured. Echocardiography was performed to measure the LV ejection fraction (LVEF) and LV dilation. Plasma miR-143 and miR-145 levels were significantly higher in patients with heart diseases than in controls, respectively. Plasma miR-143 and miR-145 levels were significantly higher in patients with LVEF < 50% than in those with LVEF ≧ 50%, respectively. Plasma miR-143 and miR-145 levels were inversely correlated with LVEF, respectively. Plasma miR-143 and miR-145 levels were positively correlated with LV end-systolic dimension, respectively. Plasma miR-143 and -145 levels were positively correlated with plasma BNP levels, respectively. Plasma BNP levels were inversely correlated with LVEF. Plasma miR-143 and miR-145 levels are elevated in patients with LV dysfunction and may counteract LV dysfunction., (© 2024. The Author(s).)

Published
2024
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94. Additional renoprotective effect of the SGLT2 inhibitor dapagliflozin in a patient with ADPKD receiving tolvaptan treatment.

Author

Minatoguchi S, Hayashi H, Umeda R, Koide S, Hasegawa M, and Tsuboi N

Subjects
Humans, Female, Adult, Glomerular Filtration Rate drug effects, Treatment Outcome, Kidney pathology, Kidney drug effects, Tolvaptan therapeutic use, Benzhydryl Compounds therapeutic use, Benzhydryl Compounds pharmacology, Sodium-Glucose Transporter 2 Inhibitors therapeutic use, Sodium-Glucose Transporter 2 Inhibitors pharmacology, Polycystic Kidney, Autosomal Dominant drug therapy, Glucosides therapeutic use, Glucosides pharmacology, Antidiuretic Hormone Receptor Antagonists therapeutic use
Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of end-stage kidney disease (ESKD). Vasopressin plays a pivotal role in ADPKD progression; therefore, the selective vasopressin V2 receptor antagonist tolvaptan is used as a key drug in the management of ADPKD. On the other hand, sodium-glucose cotransporter-2 inhibitors (SGLT2i), which may possibly stimulate vasopressin secretion due to the diuretic effect of the drug, have been shown to have both renal and cardioprotective effects in various populations, including those with non-diabetic chronic kidney disease. However, the effect of SGLT2i in patients with ADPKD have not been fully elucidated. Herein, we report the case of a patient with ADPKD on tolvaptan who was administered the SGLT2i dapagliflozin. The patient was a Japanese woman diagnosed with ADPKD at age 30. Despite the treatment with tolvaptan, eGFR was gradually declined from 79.8 to 50 ml/min/1.73 m 2 in almost 5 years and 10 mg of dapagliflozin was initiated in the hope of renoprotective effects. Although a small increase in vasopressin levels was observed, eGFR decline rate was moderated after dapagliflozin initiation. This case suggested an additional renoprotective effect of dapagliflozin in patient with ADPKD receiving tolvaptan. Although there is no evidence about the renal protective effect of SGLT2i in patients with ADPKD, we hereby report a case successfully treated with dapagliflozin for approximately 2 years. Further research, including clinical trials, is needed to evaluate whether SGLT2i are effective in patients with ADPKD., (© 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology.)

Published
2024
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95. Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment.

Author

Minatoguchi S, Fujita Y, Niizuma K, Tominaga T, Yamashita T, Abe K, and Dezawa M

Subjects
Humans, Mesenchymal Stem Cell Transplantation methods, Immunosuppressive Agents pharmacology, Immunosuppressive Agents therapeutic use, HLA Antigens metabolism, Cell Differentiation, Animals, Histocompatibility Testing methods, Mesenchymal Stem Cells cytology, Mesenchymal Stem Cells metabolism
Abstract

The strength of stem cell therapy is the regeneration of tissues by synergistic pleiotropic effects. Among many stem cell types, mesenchymal stem cells (MSCs) that are comprised of heterogenous population are widely used for clinical applications with the expectation of pleiotropic bystander effects. Muse cells are pluripotent-like/macrophage-like stem cells distributed in the bone marrow, peripheral blood, and organ connective tissues as cells positive for the pluripotent surface marker stage-specific-embryonic antigen -3. Muse cells comprise ~1% to several percent of MSCs. While Muse cells and MSCs share several characteristics, such as mesenchymal surface marker expression and their bystander effects, Muse cells exhibit unique characteristics not observed in MSCs. These unique characteristics of Muse cells include selective homing to damaged tissue after intravenous injection rather than being trapped in the lung like MSCs, replacement of a wide range of damaged/apoptotic cells by differentiation through phagocytosis, and long-lasting immunotolerance for donor cell use. In this review, we focus on the basic properties of Muse cells clarified through preclinical studies and clinical trials conducted by intravenous injection of donor-Muse cells without HLA-matching tests or immunosuppressant treatment. MSCs are considered to differentiate into osteogenic, chondrogenic, and adipogenic cells, whereas the range of their differentiation has long been debated. Muse cells may provide clues to the wide-ranging differentiation potential of MSCs that are observed with low frequency. Furthermore, the utilization of Muse cells may provide a novel strategy for clinical treatment., (© The Author(s) 2024. Published by Oxford University Press.)

Published
2024
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96. Effects of Repeated Kurort Health Walking on Blood Pressure and Mental Health.

Author

Minatoguchi S, Minagawa T, Osawa K, Ojio S, Yasuda S, Marumo T, and Takahashi S

Abstract

Background: The German word "kurort" means cure (kur) and area (ort), whereby a patient's health improves through walking in areas full of nature. A single session of kurort health walking (kurort) decreased high blood pressure and improved mental health. However, its continuing effect with repeat sessions remains unclear., Methods and Results: The subjects participated twice in kurort health walking in specially designated courses in Gifu City (n=242). Systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR) were measured before and after kurort health walking. Mental health was assessed using a 10-item checklist after kurort health walking. Both basal SBP and DBP before walking were significantly decreased more in the second session than in the first. In both the first and second sessions SBP and DBP decreased, but the decrease in SBP (∆SBP) by kurort was significantly greater in the SBP ≥140- than in the SBP <140-mmHg group, SBP inversely correlated with ∆SBP, the decrease in DBP (∆DBP) was significantly greater in the DBP ≥90- than in the DBP <90-mmHg group, and DBP inversely correlated with ∆DBP. Mental health was similarly improved after both the first and second kurort., Conclusions: Basal SBP and DBP decreased more in the second than in the first kurort. The decrease in SBP and DBP, and improvement of mental health was noted after both sessions., Competing Interests: S.M. is a member of Circulation Reports’ Editorial Team. The other authors declare that no conflicts of interest exist., (Copyright © 2024, THE JAPANESE CIRCULATION SOCIETY.)

Published
2024
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97. Importance of the Vegetable and Fruit Intake for Health Based on the Relationship between Urinary Potassium Excretion and Cerebro-cardiovascular-renal Events or All-cause Mortality.

Author

Minatoguchi S

Subjects
Humans, Fruit, Potassium, Sodium Chloride, Dietary, Diet, Vegetables, Hypertension
Abstract

Since it is widely accepted that there is a positive correlation between the salt intake and hypertension or cerebro-cardiovascular-renal events, salt intake restriction is currently widely recommended, especially in patients with hypertension. However, salt intake restriction does not always have beneficial effects. Indeed, an excessively low salt intake has been reported to be harmful to health. While a reasonable vegetable and fruit intake reportedly decreases blood pressure, whether or not vegetable and fruit intake truly leads to reductions in cerebro-cardiovascular-renal events or all-cause mortality remains unclear. We reviewed the importance of vegetable and fruit intake for health, focusing on the relationship between urinary potassium excretion, a marker of vegetable and fruit intake, and cerebro-cardiovascular-renal events or all-cause mortality. In conclusion, vegetable and fruit intake may be essential for reducing cerebro-cardiovascular-renal events and all-cause mortality.

Published
2024
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98. Predictors of Suboptimal Lumen Expansion Following Intravascular Lithotripsy for Coronary In-Stent Restenosis.

Author

Yasumura K, Koshy AN, Vengrenyuk Y, Minatoguchi S, Hooda A, Sharma R, Kapur V, Sweeny J, Sharma SK, and Kini AS

Subjects
Humans, Treatment Outcome, Stents, Coronary Angiography, Ultrasonography, Interventional, Coronary Restenosis diagnostic imaging, Coronary Restenosis etiology, Coronary Restenosis therapy, Lithotripsy adverse effects
Published
2024
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99. Sodium zirconium cyclosilicate reconciles management of hyperkalemia and continuity of renin-angiotensin-aldosterone system inhibitors: a retrospective observational study.

Author

Kimura W, Minatoguchi S, Mizuno T, Koide S, Hayashi H, Hasegawa M, Inaguma D, and Tsuboi N

Subjects
Humans, Renin-Angiotensin System, Potassium, Angiotensin-Converting Enzyme Inhibitors adverse effects, Polymers pharmacology, Antihypertensive Agents, Angiotensin Receptor Antagonists adverse effects, Hyperkalemia diagnosis, Hyperkalemia drug therapy, Renal Insufficiency, Chronic, Polystyrenes, Silicates
Abstract

Background: Sodium zirconium cyclosilicate, a non-absorbed non-polymer zirconium silicate, is a new potassium binder for hyperkalemia. A previous report showed that administering sodium zirconium cyclosilicate to patients with hyperkalemia allows a higher continuation rate of renin-angiotensin-aldosterone system inhibitors. However, no studies have compared sodium zirconium cyclosilicate with existing potassium binders for renin-angiotensin-aldosterone system inhibitor continuity. The purpose of this study was to evaluate the effect of sodium zirconium cyclosilicate on angiotensin-converting enzyme inhibitor /angiotensin receptor blocker continuation in patients with hyperkalemia compared to that of calcium polystyrene sulfonate., Methods: Patients on angiotensin-converting enzyme inhibitors/angiotensin receptor blockers who were newly prescribed sodium zirconium cyclosilicate or calcium polystyrene sulfonate to treat hyperkalemia at a tertiary referral hospital between August 2020 and April 2022 were enrolled in this single-center, retrospective observational study. The primary outcome measure was angiotensin-converting enzyme inhibitor/angiotensin receptor blocker prescription three months after initiating potassium binders., Results: In total, 174 patients on angiotensin-converting enzyme inhibitors/angiotensin receptor blockers who were newly administered sodium zirconium cyclosilicate (n = 62) or calcium polystyrene sulfonate (n = 112) were analyzed. The prescription rate of angiotensin-converting enzyme inhibitors /angiotensin receptor blockers at 3 months was significantly higher in the sodium zirconium cyclosilicate group than in the calcium polystyrene sulfonate group (89 vs. 72%). Multivariate logistic regression models showed that sodium zirconium cyclosilicate was independently associated with the primary outcome (odds ratio 2.66, 95% confidence interval 1.05-7.43). The propensity score-matched comparison also showed a significant association between sodium zirconium cyclosilicate and the primary outcome., Conclusions: Our study suggests that administering sodium zirconium cyclosilicate to patients with hyperkalemia allows for a higher continuation rate of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers than calcium polystyrene sulfonate. These findings suggest that sodium zirconium cyclosilicate has potential benefits for patients with chronic kidney disease receiving renin-angiotensin-aldosterone system inhibitors., (© 2023. The Author(s) under exclusive licence to Italian Society of Nephrology.)

Published
2024
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100. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.

Author

Ando R, Shiraki Y, Miyai Y, Shimizu H, Furuhashi K, Minatoguchi S, Kato K, Kato A, Iida T, Mizutani Y, Ito K, Asai N, Mii S, Esaki N, Takahashi M, and Enomoto A

Subjects
Animals, Humans, Mice, Fibrosis, Pancreas pathology, Pancreatic Stellate Cells pathology, Regeneration, Carcinoma, Pancreatic Ductal pathology, Pancreatic Neoplasms pathology, Pancreatitis, Chronic genetics, Pancreatitis, Chronic metabolism, Pancreatitis, Chronic pathology
Abstract

Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblasts or cancer-associated fibroblasts (CAFs) that promote stromal fibroinflammatory reactions. However, previous studies on PSCs were mainly based on the findings obtained using ex vivo expanded PSCs, with few studies that addressed the significance of in situ tissue-resident PSCs using animal models. Their contributions to fibrotic reactions in CP and PDAC are also lesser-known. These limitations in our understanding of PSC biology have been attributed to the lack of specific molecular markers of PSCs. Herein, we established Meflin (Islr), a glycosylphosphatidylinositol-anchored membrane protein, as a PSC-specific marker in both mouse and human by using human pancreatic tissue samples and Meflin reporter mice. Meflin-positive (Meflin + ) cells contain lipid droplets and express the conventional PSC marker Desmin in normal mouse pancreas, with some cells also positive for Gli1, the marker of pancreatic tissue-resident fibroblasts. Three-dimensional analysis of the cleared pancreas of Meflin reporter mice showed that Meflin + PSCs have long and thin cytoplasmic protrusions, and are localised on the abluminal side of vessels in the normal pancreas. Lineage tracing experiments revealed that Meflin + PSCs constitute one of the origins of fibroblasts and CAFs in CP and PDAC, respectively. In these diseases, Meflin + PSC-derived fibroblasts showed a distinctive morphology and distribution from Meflin + PSCs in the normal pancreas. Furthermore, we showed that the genetic depletion of Meflin + PSCs accelerated fibrosis and attenuated epithelial regeneration and stromal R-spondin 3 expression, thereby implying that Meflin + PSCs and their lineage cells may support tissue recovery and Wnt/R-spondin signalling after pancreatic injury and PDAC development. Together, these data indicate that Meflin may be a marker specific to tissue-resident PSCs and useful for studying their biology in both health and disease. © 2023 The Pathological Society of Great Britain and Ireland., (© 2023 The Pathological Society of Great Britain and Ireland.)

Published
2024
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