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53. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Author

Logue, Mark W., van Rooij, Sanne J.H., Dennis, Emily L., Davis, Sarah L., Hayes, Jasmeet P., Stevens, Jennifer S., Densmore, Maria, Haswell, Courtney C., Ipser, Jonathan, Koch, Saskia B.J., Korgaonkar, Mayuresh, Lebois, Lauren A.M., Peverill, Matthew, Baker, Justin T., Boedhoe, Premika S.W., Frijling, Jessie L., Gruber, Staci A., Harpaz-Rotem, Ilan, Jahanshad, Neda, Koopowitz, Sheri, Levy, Ifat, Nawijn, Laura, O’Connor, Lauren, Olff, Miranda, Salat, David H., Sheridan, Margaret A., Spielberg, Jeffrey M., van Zuiden, Mirjam, Winternitz, Sherry R., Wolff, Jonathan D., Wolf, Erika J., Wang, Xin, Wrocklage, Kristen, Abdallah, Chadi G., Bryant, Richard A., Geuze, Elbert, Jovanovic, Tanja, Kaufman, Milissa L., King, Anthony P., Krystal, John H., Lagopoulos, Jim, Bennett, Maxwell, Lanius, Ruth, Liberzon, Israel, McGlinchey, Regina E., McLaughlin, Katie A., Milberg, William P., Miller, Mark W., Ressler, Kerry J., Veltman, Dick J., Stein, Dan J., Thomaes, Kathleen, Thompson, Paul M., and Morey, Rajendra A.

Published
2018
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54. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

Author

Yang, Jin, primary, Huggins, Ashley A., additional, Sun, Delin, additional, Baird, C. Lexi, additional, Haswell, Courtney C., additional, Frijling, Jessie L., additional, Olff, Miranda, additional, van Zuiden, Mirjam, additional, Koch, Saskia B. J., additional, Nawijn, Laura, additional, Veltman, Dick J., additional, Suarez-Jimenez, Benjamin, additional, Zhu, Xi, additional, Neria, Yuval, additional, Hudson, Anna R., additional, Mueller, Sven C., additional, Baker, Justin T., additional, Lebois, Lauren A. M., additional, Kaufman, Milissa L., additional, Qi, Rongfeng, additional, Lu, Guang Ming, additional, Říha, Pavel, additional, Rektor, Ivan, additional, Dennis, Emily L., additional, Ching, Christopher R. K., additional, Thomopoulos, Sophia I., additional, Salminen, Lauren E., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Stein, Dan J., additional, Koopowitz, Sheri M., additional, Ipser, Jonathan C., additional, Seedat, Soraya, additional, du Plessis, Stefan, additional, van den Heuvel, Leigh L., additional, Wang, Li, additional, Zhu, Ye, additional, Li, Gen, additional, Sierk, Anika, additional, Manthey, Antje, additional, Walter, Henrik, additional, Daniels, Judith K., additional, Schmahl, Christian, additional, Herzog, Julia I., additional, Liberzon, Israel, additional, King, Anthony, additional, Angstadt, Mike, additional, Davenport, Nicholas D., additional, Sponheim, Scott R., additional, Disner, Seth G., additional, Straube, Thomas, additional, Hofmann, David, additional, Grupe, Daniel W., additional, Nitschke, Jack B., additional, Davidson, Richard J., additional, Larson, Christine L., additional, deRoon-Cassini, Terri A., additional, Blackford, Jennifer U., additional, Olatunji, Bunmi O., additional, Gordon, Evan M., additional, May, Geoffrey, additional, Nelson, Steven M., additional, Abdallah, Chadi G., additional, Levy, Ifat, additional, Harpaz-Rotem, Ilan, additional, Krystal, John H., additional, Morey, Rajendra A., additional, and Sotiras, Aristeidis, additional

Published
2023
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55. Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture

Author

Morey, Rajendra, primary, Zheng, Yuanchao, additional, Sun, Delin, additional, Garrett, Melanie, additional, Gasperi, Marianna, additional, Maihofer, Adam, additional, Baird, C. Lexi, additional, Grasby, Katrina, additional, Huggins, Ashley, additional, Haswell, Courtney, additional, Thompson, Paul, additional, Medland, Sarah, additional, Gustavson, Daniel, additional, Panizzon, Matthew, additional, Kremen, William, additional, Nievergelt, Caroline, additional, Ashley-Koch, Allison, additional, and Logue, Logue, additional

Published
2023
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58. PROGRESS AND PROMISE OF NEUROGENETICS METHODS TO STUDY PTSD

Author

Morey, Rajendra, primary, Logue, Mark, additional, Maihofer, Adam X., additional, Nievergelt, Caroline, additional, Ashley-Koch, Allison, additional, Garrett, Melanie, additional, Haswell, Courtney, additional, Mufford, Maryanne, additional, Dalvie, Shareefa, additional, Katrinli, Seyma, additional, Medland, Sarah E., additional, and Thompson, Paul, additional

Published
2023
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60. Current progress and future direction in the genetics of PTSD: Focus on the development and contributions of the PGC-PTSD working group

Author

Junglen, Angela G., primary, Sheerin, Christina, additional, Delahanty, Douglas L., additional, Hauser, Michael A., additional, Lori, Adriana, additional, Morey, Rajendra A., additional, Nievergelt, Caroline M., additional, Nugent, Nicole R., additional, Sebat, Jonathan, additional, Smith, Alicia K., additional, Sumner, Jennifer A., additional, Uddin, Monica, additional, and Amstadter, Ananda B., additional

Published
2020
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61. White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study

Author

Lepage, Christian, de Pierrefeu, Amicie, Koerte, Inga K., Coleman, Michael J., Pasternak, Ofer, Grant, Gerald, Marx, Christine E., Morey, Rajendra A., Flashman, Laura A., George, Mark S., McAllister, Thomas W., Andaluz, Norberto, Shutter, Lori, Coimbra, Raul, Zafonte, Ross D., Stein, Murray B., Shenton, Martha E., and Bouix, Sylvain

Published
2018
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62. Contributors

Author

Abbott, Ryan, primary, Ahmed, Ahmed T., additional, Alda, Martin, additional, Amstadter, Ananda B., additional, Andreassen, Ole A., additional, Arnet, Victoria K., additional, Bardy, Cedric, additional, Barta, Csaba, additional, Baune, Bernhard T., additional, Becker, Elisabeth R.B., additional, Bewernick, Bettina H., additional, Biernacka, Joanna M., additional, Bleich, Stefan, additional, Blumenthal, Marissa S., additional, Bonvicini, Cristian, additional, Bousman, Chad A., additional, Brown, Lisa C., additional, Burton, Christie L., additional, Cao, Han, additional, Carpenter, Joanne S., additional, Cath, Danielle, additional, Cearns, Micah, additional, Chang, Donald D., additional, Charney, Alexander, additional, Ching, Christopher R.K., additional, Chitty, Kate M., additional, Ciobanu, Liliana G., additional, Clark, Scott R., additional, Cole, A.M., additional, Collinson, Jane L., additional, Colodro-Conde, Lucía, additional, Corvin, A., additional, Cotter, David R., additional, Cross, Shane P.M., additional, Crouse, Jacob J., additional, Cryan, John F, additional, Czamara, Darina, additional, Dalvie, Shareefa, additional, Degenhardt, Franziska, additional, Delahanty, Douglas L., additional, Dinan, Timothy G, additional, Eapen, Valsamma, additional, Eyre, Harris A., additional, Forstner, Andreas J., additional, Frieling, Helge, additional, Frye, Mark A., additional, Gehue, Lillian J., additional, Geller, Daniel, additional, Glozier, Nicholas, additional, Godlewska, Beata R., additional, Goldstein-Piekarski, Andrea N., additional, Gorbovskaya, Ilona, additional, Grabe, Hans Jörgen, additional, Grande, Iria, additional, Grant, Paul, additional, Greenberg, Zarina, additional, Grünblatt, Edna, additional, Guastella, Adam J., additional, Gururajan, Anand, additional, Hahn, Tim, additional, Hall, Alisha S.M., additional, Hamilton, Blake A., additional, Hamm, Alfons O., additional, Harmer, Catherine J., additional, Hartmann, Jessica, additional, Hauser, Michael A., additional, Hermens, Daniel F., additional, Hickie, Ian B., additional, Iorfino, Frank, additional, Jahanshad, Neda, additional, Jansen, Iris E., additional, Junglen, Angela G., additional, Karim, Helmet T., additional, Kaur, Manreena, additional, Koen, Nastassja, additional, Koethe, Dagmar, additional, Lagopoulos, Jim, additional, Lee, Rico S.Z., additional, Legge, Sophie E., additional, Levinson, Douglas F., additional, Leweke, F. Markus, additional, Licinio, Julio, additional, Linden, David E.J., additional, Liu, Jonathan C.W., additional, Lo, Anita, additional, Lohoff, Falk W., additional, Lori, Adriana, additional, Lueken, Ulrike, additional, Maj, Carlo, additional, McGorry, Patrick D., additional, McIntyre, Roger S., additional, McMahon, Agnes B., additional, Mehta, Divya, additional, Mei, Cristina, additional, Morey, Rajendra A., additional, Müller, Daniel J., additional, Naismith, Sharon L., additional, Nelson, Barnaby, additional, Neyazi, Alexandra, additional, Nichles, Alissa, additional, Nievergelt, Caroline M., additional, Nugent, Nicole R., additional, Ormond, C., additional, Pardiñas, Antonio F., additional, Perry, Seth W., additional, Pisanu, Claudia, additional, Posthuma, Danielle, additional, Ragguett, Renee-Marie, additional, Raji, Cyrus, additional, Raygada, Margarita, additional, Rennert, Owen M., additional, Reynolds, Charles F., additional, Sabherwal, Sophie, additional, Salagre, Estela, additional, Saunders, Pamela H., additional, Scassellati, Catia, additional, Schlaepfer, Thomas E., additional, Schmaal, Lianne, additional, Schubert, Klaus Oliver, additional, Schwarz, Emanuel, additional, Scott, Elizabeth M., additional, Scott, Jan, additional, Sebat, Jonathan, additional, Severino, Giovanni, additional, Sheerin, Christina, additional, Singh, Ajeet B., additional, Singh, Balwinder, additional, Smagula, Stephen F., additional, Smeland, Olav B., additional, Smith, Alicia K., additional, Sorcher, Jill L., additional, Spooner, Rachael, additional, Squassina, Alessio, additional, Stahl, Eli A., additional, Stein, Dan J., additional, Streit, Fabian, additional, Sullivan, Patrick F., additional, Sumner, Jennifer A., additional, Thompson, Paul M., additional, Tickell, Ashleigh M., additional, Toben, Catherine, additional, Uddin, Monica, additional, Vahabzadeh, Arshya, additional, Van, Linh K., additional, van de Weijer, Margot P., additional, van den Heuvel, Odile A., additional, Van der Auwera, Sandra, additional, Verboven, Anouk H.A., additional, Vieta, Eduard, additional, Wainer, Zoe, additional, Walters, James T.R., additional, Watson, Hunna J., additional, White, Django, additional, Williams, Leanne M., additional, Witt, Stephanie H., additional, Yao, Yin, additional, Yilmaz, Zeynep, additional, Zai, Gwyneth, additional, and Zmicerevska, Natalia, additional

Published
2019
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63. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Author

Nievergelt, Caroline M., Maihofer, Adam X., Klengel, Torsten, Atkinson, Elizabeth G., Chen, Chia-Yen, Choi, Karmel W., Coleman, Jonathan R. I., Dalvie, Shareefa, Duncan, Laramie E., Gelernter, Joel, Levey, Daniel F., Logue, Mark W., Polimanti, Renato, Provost, Allison C., Ratanatharathorn, Andrew, Stein, Murray B., Torres, Katy, Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Søren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Børglum, Anders D., Bradley, Bekh, Brashear, Megan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas- de- Almeida, José M., Dale, Anders M., Daly, Mark J., Daskalakis, Nikolaos P., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Dzubur-Kulenovic, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Geuze, Elbert, Gillespie, Charles, Uka, Aferdita Goci, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Harnal, Supriya, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M. J., Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Junglen, Angela G., Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A. M., Lewis, Catrin E., Linnstaedt, Sarah D., Lori, Adriana, Lugonja, Bozo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica, Marmar, Charles, Martin, Alicia R., Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., McLeay, Sarah, Mehta, Divya, Milberg, William P., Miller, Mark W., Morey, Rajendra A., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben B., Neale, Benjamin M., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O’Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, John P., Ripke, Stephan, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Ken, Rung, Ariane, Rutten, Bart P. F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S., Sumner, Jennifer A., Teicher, Martin H., Thompson, Wesley K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., van den Heuvel, Leigh Luella, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Wolff, Jonathan D., Yehuda, Rachel, Young, Ross McD., Young, Keith A., Zhao, Hongyu, Zoellner, Lori A., Liberzon, Israel, Ressler, Kerry J., Haas, Magali, and Koenen, Karestan C.

Published
2019
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64. Bridging big data: procedures for combining non-equivalent cognitive measures from the ENIGMA Consortium

Author

ENIGMA Consortium, Kennedy, Eamonn, Vadlamani, Shashank, Lindsey, Hannah M., Lei, Pui-Wa, Jo-Pugh, Mary, Adamson, Maheen, Alda, Martin, Alonso-Lana, Silvia, Ambrogi, Sonia, Anderson, Tim J., Arango, Celso, Asarnow, Robert F., Avram, Mihai, Ayesa-Arriola, Rosa, Babikian, Talin, Banaj, Nerisa, Bird, Laura J., Borgwardt, Stefan, Brodtmann, Amy, Brosch, Katharina, Caeyenberghs, Karen, Calhoun, Vince D., Chiaravalloti, Nancy D., Cifu, David X., Crespo-Facorro, Benedicto, Dalrymple-Alford, John C., Dams-O’Connor, Kristen, Dannlowski, Udo, Darby, David, Davenport, Nicholas, DeLuca, John, Díaz-Caneja, Covadonga M., Disner, Seth G., Dobryakova, Ekaterina, Ehrlich, Stefan, Esopenko, Carrie, Ferrarelli, Fabio, Frank, Lea E., Franz, Carol, Fuentes-Claramonte, Paola, Genova, Helen, Giza, Christopher C., Goltermann, Janik, Grotegerd, Dominik, Gruber, Marius, Gutiérrez-Zotes, Alfonso, Ha, Minji, Haavik, Jan, Hinkin, Charles, Hoskinson, Kristen R., Hubl, Daniela, Irimia, Andrei, Jansen, Andreas, Kaess, Michael, Kang, Xiaojian, Kenney, Kimbra, Keřková, Barbora, Khlif, Mohamed Salah, Kim, Minah, Kindler, Jochen, Kircher, Tilo, Knı́žková, Karolina, Kolskår, Knut K., Krch, Denise, Kremen, William S., Kuhn, Taylor, Kumari, Veena, Kwon, Jun Soo, Langella, Roberto, Laskowitz, Sarah, Lee, Jungha, Lengenfelder, Jean, Liebel, Spencer W., Liou-Johnson, Victoria, Lippa, Sara M., Løvstad, Marianne, Lundervold, Astri, Marotta, Cassandra, Marquardt, Craig A., Mattos, Paulo, Mayeli, Ahmad, McDonald, Carrie R., Meinert, Susanne, Melzer, Tracy R., Merchán Naranjo, Jessica, Michel, Chantal, Morey, Rajendra A., Mwangi, Benson, Myall, Daniel J., Nenadić, Igor, Newsome, Mary R., Nunes, Abraham, O’Brien, Terence J., Oertel, Viola, Ollinger, John, Olsen, Alexander, Ortiz Garcı́a de la Foz, Victor, Ozmen, Mustafa, Pardoe, Heath, Parent, Marise, Piras, Fabrizio, Piras, Federica, Pomarol-Clotet, Edith, Repple, Jonathan, Richard, Geneviève, Rodriguez, Jonathan, Rodriguez, Mabel, Rootes-Murdy, Kelly, Rowland, Jared, Ryan, Nicholas P., Salvador, Raymond, Sanders, Anne-Marthe, Schmidt, André, Soares, Jair C., Spalleta, Gianfranco, Španiel, Filip, Stasenko, Alena, Stein, Frederike, Straube, Benjamin, Thames, April, Thomas-Odenthal, Florian, Thomopoulos, Sophia I., Tone, Erin, Torres, Ivan, Troyanskaya, Maya, Turner, Jessica A., Ulrichsen, Kristine M., Umpierrez, Guillermo, Vilella, Elisabet, Vivash, Lucy, Walker, William C., Werden, Emilio, Westlye, Lars T., Wild, Krista, Wroblewski, Adrian, Wu, Mon-Ju, Wylie, Glenn R., Yatham, Lakshmi N., Zunta-Soares, Giovana B., Thompson, Paul M., Tate, David F., Hillary, Frank G., Dennis, Emily L., Wilde, Elisabeth A., ENIGMA Consortium, Kennedy, Eamonn, Vadlamani, Shashank, Lindsey, Hannah M., Lei, Pui-Wa, Jo-Pugh, Mary, Adamson, Maheen, Alda, Martin, Alonso-Lana, Silvia, Ambrogi, Sonia, Anderson, Tim J., Arango, Celso, Asarnow, Robert F., Avram, Mihai, Ayesa-Arriola, Rosa, Babikian, Talin, Banaj, Nerisa, Bird, Laura J., Borgwardt, Stefan, Brodtmann, Amy, Brosch, Katharina, Caeyenberghs, Karen, Calhoun, Vince D., Chiaravalloti, Nancy D., Cifu, David X., Crespo-Facorro, Benedicto, Dalrymple-Alford, John C., Dams-O’Connor, Kristen, Dannlowski, Udo, Darby, David, Davenport, Nicholas, DeLuca, John, Díaz-Caneja, Covadonga M., Disner, Seth G., Dobryakova, Ekaterina, Ehrlich, Stefan, Esopenko, Carrie, Ferrarelli, Fabio, Frank, Lea E., Franz, Carol, Fuentes-Claramonte, Paola, Genova, Helen, Giza, Christopher C., Goltermann, Janik, Grotegerd, Dominik, Gruber, Marius, Gutiérrez-Zotes, Alfonso, Ha, Minji, Haavik, Jan, Hinkin, Charles, Hoskinson, Kristen R., Hubl, Daniela, Irimia, Andrei, Jansen, Andreas, Kaess, Michael, Kang, Xiaojian, Kenney, Kimbra, Keřková, Barbora, Khlif, Mohamed Salah, Kim, Minah, Kindler, Jochen, Kircher, Tilo, Knı́žková, Karolina, Kolskår, Knut K., Krch, Denise, Kremen, William S., Kuhn, Taylor, Kumari, Veena, Kwon, Jun Soo, Langella, Roberto, Laskowitz, Sarah, Lee, Jungha, Lengenfelder, Jean, Liebel, Spencer W., Liou-Johnson, Victoria, Lippa, Sara M., Løvstad, Marianne, Lundervold, Astri, Marotta, Cassandra, Marquardt, Craig A., Mattos, Paulo, Mayeli, Ahmad, McDonald, Carrie R., Meinert, Susanne, Melzer, Tracy R., Merchán Naranjo, Jessica, Michel, Chantal, Morey, Rajendra A., Mwangi, Benson, Myall, Daniel J., Nenadić, Igor, Newsome, Mary R., Nunes, Abraham, O’Brien, Terence J., Oertel, Viola, Ollinger, John, Olsen, Alexander, Ortiz Garcı́a de la Foz, Victor, Ozmen, Mustafa, Pardoe, Heath, Parent, Marise, Piras, Fabrizio, Piras, Federica, Pomarol-Clotet, Edith, Repple, Jonathan, Richard, Geneviève, Rodriguez, Jonathan, Rodriguez, Mabel, Rootes-Murdy, Kelly, Rowland, Jared, Ryan, Nicholas P., Salvador, Raymond, Sanders, Anne-Marthe, Schmidt, André, Soares, Jair C., Spalleta, Gianfranco, Španiel, Filip, Stasenko, Alena, Stein, Frederike, Straube, Benjamin, Thames, April, Thomas-Odenthal, Florian, Thomopoulos, Sophia I., Tone, Erin, Torres, Ivan, Troyanskaya, Maya, Turner, Jessica A., Ulrichsen, Kristine M., Umpierrez, Guillermo, Vilella, Elisabet, Vivash, Lucy, Walker, William C., Werden, Emilio, Westlye, Lars T., Wild, Krista, Wroblewski, Adrian, Wu, Mon-Ju, Wylie, Glenn R., Yatham, Lakshmi N., Zunta-Soares, Giovana B., Thompson, Paul M., Tate, David F., Hillary, Frank G., Dennis, Emily L., and Wilde, Elisabeth A.

Abstract

Investigators in the cognitive neurosciences have turned to Big Data to address persistent replication and reliability issues by increasing sample sizes, statistical power, and representativeness of data. While there is tremendous potential to advance science through open data sharing, these efforts unveil a host of new questions about how to integrate data arising from distinct sources and instruments. We focus on the most frequently assessed area of cognition - memory testing - and demonstrate a process for reliable data harmonization across three common measures. We aggregated raw data from 53 studies from around the world which measured at least one of three distinct verbal learning tasks, totaling N = 10,505 healthy and brain-injured individuals. A mega analysis was conducted using empirical bayes harmonization to isolate and remove site effects, followed by linear models which adjusted for common covariates. After corrections, a continuous item response theory (IRT) model estimated each individual subject’s latent verbal learning ability while accounting for item difficulties. Harmonization significantly reduced inter-site variance by 37% while preserving covariate effects. The effects of age, sex, and education on scores were found to be highly consistent across memory tests. IRT methods for equating scores across AVLTs agreed with held-out data of dually-administered tests, and these tools are made available for free online. This work demonstrates that large-scale data sharing and harmonization initiatives can offer opportunities to address reproducibility and integration challenges across the behavioral sciences.

Published
2023

65. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium

Author

MGGZ, Brain, Zhu, Xi, Kim, Yoojean, Ravid, Orren, He, Xiaofu, Suarez-Jimenez, Benjamin, Zilcha-Mano, Sigal, Lazarov, Amit, Lee, Seonjoo, Abdallah, Chadi G., Angstadt, Michael, Averill, Christopher L., Baird, C. Lexi, Baugh, Lee A., Blackford, Jennifer U., Bomyea, Jessica, Bruce, Steven E., Bryant, Richard A., Cao, Zhihong, Choi, Kyle, Cisler, Josh, Cotton, Andrew S., Daniels, Judith K., Davenport, Nicholas D., Davidson, Richard J., DeBellis, Michael D., Dennis, Emily L., Densmore, Maria, deRoon-Cassini, Terri, Disner, Seth G., Hage, Wissam El, Etkin, Amit, Fani, Negar, Fercho, Kelene A., Fitzgerald, Jacklynn, Forster, Gina L., Frijling, Jessie L., Geuze, Elbert, Gonenc, Atilla, Gordon, Evan M., Gruber, Staci, Grupe, Daniel W., Guenette, Jeffrey P., Haswell, Courtney C., Herringa, Ryan J., Herzog, Julia, Hofmann, David Bernd, Hosseini, Bobak, Hudson, Anna R., Huggins, Ashley A., Ipser, Jonathan C., Jahanshad, Neda, Jia-Richards, Meilin, Jovanovic, Tanja, Kaufman, Milissa L., Kennis, Mitzy, King, Anthony, Kinzel, Philipp, Koch, Saskia B.J., Koerte, Inga K., Koopowitz, Sheri M., Korgaonkar, Mayuresh S., Krystal, John H., Lanius, Ruth, Larson, Christine L., Lebois, Lauren A.M., Li, Gen, Liberzon, Israel, Lu, Guang Ming, Luo, Yifeng, Magnotta, Vincent A., Manthey, Antje, Maron-Katz, Adi, May, Geoffery, McLaughlin, Katie, Mueller, Sven C., Nawijn, Laura, Nelson, Steven M., Neufeld, Richard W.J., Nitschke, Jack B., O'Leary, Erin M., Olatunji, Bunmi O., Olff, Miranda, Peverill, Matthew, Phan, K. Luan, Qi, Rongfeng, Quidé, Yann, Rektor, Ivan, Ressler, Kerry, Riha, Pavel, Ross, Marisa, Rosso, Isabelle M., Salminen, Lauren E., Sambrook, Kelly, Schmahl, Christian, Shenton, Martha E., Sheridan, Margaret, Shih, Chiahao, Sicorello, Maurizio, Sierk, Anika, Simmons, Alan N., Simons, Raluca M., Simons, Jeffrey S., Sponheim, Scott R., Stein, Murray B., Stein, Dan J., Stevens, Jennifer S., Straube, Thomas, Sun, Delin, Théberge, Jean, Thompson, Paul M., Thomopoulos, Sophia I., van der Wee, Nic J.A., van der Werff, Steven J.A., van Erp, Theo G.M., van Rooij, Sanne J.H., van Zuiden, Mirjam, Varkevisser, Tim, Veltman, Dick J., Vermeiren, Robert R.J.M., Walter, Henrik, Wang, Li, Wang, Xin, Weis, Carissa, Winternitz, Sherry, Xie, Hong, Zhu, Ye, Wall, Melanie, Neria, Yuval, Morey, Rajendra A., MGGZ, Brain, Zhu, Xi, Kim, Yoojean, Ravid, Orren, He, Xiaofu, Suarez-Jimenez, Benjamin, Zilcha-Mano, Sigal, Lazarov, Amit, Lee, Seonjoo, Abdallah, Chadi G., Angstadt, Michael, Averill, Christopher L., Baird, C. Lexi, Baugh, Lee A., Blackford, Jennifer U., Bomyea, Jessica, Bruce, Steven E., Bryant, Richard A., Cao, Zhihong, Choi, Kyle, Cisler, Josh, Cotton, Andrew S., Daniels, Judith K., Davenport, Nicholas D., Davidson, Richard J., DeBellis, Michael D., Dennis, Emily L., Densmore, Maria, deRoon-Cassini, Terri, Disner, Seth G., Hage, Wissam El, Etkin, Amit, Fani, Negar, Fercho, Kelene A., Fitzgerald, Jacklynn, Forster, Gina L., Frijling, Jessie L., Geuze, Elbert, Gonenc, Atilla, Gordon, Evan M., Gruber, Staci, Grupe, Daniel W., Guenette, Jeffrey P., Haswell, Courtney C., Herringa, Ryan J., Herzog, Julia, Hofmann, David Bernd, Hosseini, Bobak, Hudson, Anna R., Huggins, Ashley A., Ipser, Jonathan C., Jahanshad, Neda, Jia-Richards, Meilin, Jovanovic, Tanja, Kaufman, Milissa L., Kennis, Mitzy, King, Anthony, Kinzel, Philipp, Koch, Saskia B.J., Koerte, Inga K., Koopowitz, Sheri M., Korgaonkar, Mayuresh S., Krystal, John H., Lanius, Ruth, Larson, Christine L., Lebois, Lauren A.M., Li, Gen, Liberzon, Israel, Lu, Guang Ming, Luo, Yifeng, Magnotta, Vincent A., Manthey, Antje, Maron-Katz, Adi, May, Geoffery, McLaughlin, Katie, Mueller, Sven C., Nawijn, Laura, Nelson, Steven M., Neufeld, Richard W.J., Nitschke, Jack B., O'Leary, Erin M., Olatunji, Bunmi O., Olff, Miranda, Peverill, Matthew, Phan, K. Luan, Qi, Rongfeng, Quidé, Yann, Rektor, Ivan, Ressler, Kerry, Riha, Pavel, Ross, Marisa, Rosso, Isabelle M., Salminen, Lauren E., Sambrook, Kelly, Schmahl, Christian, Shenton, Martha E., Sheridan, Margaret, Shih, Chiahao, Sicorello, Maurizio, Sierk, Anika, Simmons, Alan N., Simons, Raluca M., Simons, Jeffrey S., Sponheim, Scott R., Stein, Murray B., Stein, Dan J., Stevens, Jennifer S., Straube, Thomas, Sun, Delin, Théberge, Jean, Thompson, Paul M., Thomopoulos, Sophia I., van der Wee, Nic J.A., van der Werff, Steven J.A., van Erp, Theo G.M., van Rooij, Sanne J.H., van Zuiden, Mirjam, Varkevisser, Tim, Veltman, Dick J., Vermeiren, Robert R.J.M., Walter, Henrik, Wang, Li, Wang, Xin, Weis, Carissa, Winternitz, Sherry, Xie, Hong, Zhu, Ye, Wall, Melanie, Neria, Yuval, and Morey, Rajendra A.

Published
2023

66. Altered lateralization of the cingulum in deployment-related traumatic brain injury: An ENIGMA military-relevant brain injury study

Author

MGGZ, Brain, Dennis, Emily L., Newsome, Mary R., Lindsey, Hannah M., Adamson, Maheen, Austin, Tara A., Disner, Seth G., Eapen, Blessen C., Esopenko, Carrie, Franz, Carol E., Geuze, Elbert, Haswell, Courtney, Hinds, Sidney R., Hodges, Cooper B., Irimia, Andrei, Kenney, Kimbra, Koerte, Inga K., Kremen, William S., Levin, Harvey S., Morey, Rajendra A., Ollinger, John, Rowland, Jared A., Scheibel, Randall S., Shenton, Martha E., Sullivan, Danielle R., Talbert, Leah D., Thomopoulos, Sophia I., Troyanskaya, Maya, Walker, William C., Wang, Xin, Ware, Ashley L., Werner, John Kent, Williams, Wright, Thompson, Paul M., Tate, David F., Wilde, Elisabeth A., MGGZ, Brain, Dennis, Emily L., Newsome, Mary R., Lindsey, Hannah M., Adamson, Maheen, Austin, Tara A., Disner, Seth G., Eapen, Blessen C., Esopenko, Carrie, Franz, Carol E., Geuze, Elbert, Haswell, Courtney, Hinds, Sidney R., Hodges, Cooper B., Irimia, Andrei, Kenney, Kimbra, Koerte, Inga K., Kremen, William S., Levin, Harvey S., Morey, Rajendra A., Ollinger, John, Rowland, Jared A., Scheibel, Randall S., Shenton, Martha E., Sullivan, Danielle R., Talbert, Leah D., Thomopoulos, Sophia I., Troyanskaya, Maya, Walker, William C., Wang, Xin, Ware, Ashley L., Werner, John Kent, Williams, Wright, Thompson, Paul M., Tate, David F., and Wilde, Elisabeth A.

Published
2023

70. Childhood Trauma Exposure and PTSD Diagnosis Interact With Polygenic Determinants of Hippocampal and Amygdala Volume

Author

Logue, Mark, primary, Zheng, Yuanchao, additional, Garrett, Melanie, additional, Maihofer, Adam, additional, Clarke, Emily, additional, Haswell, Courtney, additional, Sun, Delin, additional, Peverill, Matthew, additional, McLaughlin, Katie, additional, Sambrook, Kelly, additional, Davenport, Nicholas, additional, Disner, Seth, additional, Korgaonkar, Mayuresh, additional, Bryant, Richard, additional, Varkevisser, Tim, additional, Geuze, Elbert, additional, Beckham, Jean, additional, Kimbrel, Nathan, additional, Coleman, Jonathan, additional, Sullivan, Danielle, additional, Wolf, Erika, additional, Hayes, Jasmeet, additional, Verfaellie, Mieke, additional, Salat, David, additional, Spielberg, Jeffrey M., additional, McGlinchey, Regina, additional, Milberg, William, additional, Medland, Sarah E., additional, Nievergelt, Caroline, additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Kremen, William S., additional, and Morey, Rajendra, additional

Published
2023
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71. PTSD Moderates the Association Between Brain Aging and Epigenetic Aging

Author

Katrinli, Seyma, primary, Baird, C. Lexi, additional, Huggins, Ashley, additional, Clausen, Ashley, additional, Stevens, Jennifer, additional, van Rooij, Sanne, additional, Michopoulos, Vasiliki, additional, Powers, Abigail, additional, Ressler, Kerry, additional, Garrett, Melanie, additional, Ashley-Koch, Allison, additional, Smith, Alicia, additional, and Morey, Rajendra, additional

Published
2023
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73. Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.

Author

Campos, Adrian I., primary, Van Velzen, Laura S., additional, Veltman, Dick J., additional, Pozzi, Elena, additional, Ambrogi, Sonia, additional, Ballard, Elizabeth D., additional, Banaj, Nerisa, additional, Başgöze, Zeynep, additional, Bellow, Sophie, additional, Benedetti, Francesco, additional, Bollettini, Irene, additional, Brosch, Katharina, additional, Canales-Rodríguez, Erick J., additional, Clarke-Rubright, Emily K., additional, Colic, Lejla, additional, Connolly, Colm G., additional, Courtet, Philippe, additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Dauvermann, Maria R., additional, Davey, Christopher G., additional, Deverdun, Jeremy, additional, Dohm, Katharina, additional, Erwin-Grabner, Tracy, additional, Goya-Maldonado, Roberto, additional, Fani, Negar, additional, Fortea, Lydia, additional, Fuentes-Claramonte, Paola, additional, Gonul, Ali Saffet, additional, Gotlib, Ian H., additional, Grotegerd, Dominik, additional, Harris, Mathew A., additional, Harrison, Ben J., additional, Haswell, Courtney C., additional, Hawkins, Emma L., additional, Hill, Dawson, additional, Hirano, Yoshiyuki, additional, Ho, Tiffany C., additional, Jollant, Fabrice, additional, Jovanovic, Tanja, additional, Kircher, Tilo, additional, Klimes-Dougan, Bonnie, additional, le Bars, Emmanuelle, additional, Lochner, Christine, additional, McIntosh, Andrew M., additional, Meinert, Susanne, additional, Mekawi, Yara, additional, Melloni, Elisa, additional, Mitchell, Philip, additional, Morey, Rajendra A., additional, Nakagawa, Akiko, additional, Nenadić, Igor, additional, Olié, Emilie, additional, Pereira, Fabricio, additional, Phillips, Rachel D., additional, Piras, Fabrizio, additional, Poletti, Sara, additional, Pomarol-Clotet, Edith, additional, Radua, Joaquim, additional, Ressler, Kerry J., additional, Roberts, Gloria, additional, Rodriguez-Cano, Elena, additional, Sacchet, Matthew D., additional, Salvador, Raymond, additional, Sandu, Anca-Larisa, additional, Shimizu, Eiji, additional, Singh, Aditya, additional, Spalletta, Gianfranco, additional, Steele, J. Douglas, additional, Stein, Dan J., additional, Stein, Frederike, additional, Stevens, Jennifer S., additional, Teresi, Giana I., additional, Uyar-Demir, Aslihan, additional, van der Wee, Nic J., additional, van der Werff, Steven J., additional, van Rooij, Sanne J. H., additional, Vecchio, Daniela, additional, Verdolini, Norma, additional, Vieta, Eduard, additional, Waiter, Gordon D., additional, Whalley, Heather, additional, Whittle, Sarah L., additional, Yang, Tony T., additional, Zarate, Carlos A., additional, Thompson, Paul M., additional, Jahanshad, Neda, additional, van Harmelen, Anne-Laura, additional, Blumberg, Hilary P., additional, Schmaal, Lianne, additional, and Rentería, Miguel E., additional

Published
2023
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74. Multi-site harmonization of diffusion MRI data in a registration framework

Author

Mirzaalian, Hengameh, Ning, Lipeng, Savadjiev, Peter, Pasternak, Ofer, Bouix, Sylvain, Michailovich, Oleg, Karmacharya, Sarina, Grant, Gerald, Marx, Christine E., Morey, Rajendra A., Flashman, Laura A., George, Mark S., McAllister, Thomas W., Andaluz, Norberto, Shutter, Lori, Coimbra, Raul, Zafonte, Ross D., Coleman, Mike J., Kubicki, Marek, Westin, Carl-Fredrik, Stein, Murray B., Shenton, Martha E., and Rathi, Yogesh

Published
2018
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77. The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

Author

Wendt, Frank R., primary, Garcia-Argibay, Miguel, additional, Cabrera-Mendoza, Brenda, additional, Valdimarsdóttir, Unnur A., additional, Gelernter, Joel, additional, Stein, Murray B., additional, Nivard, Michel G., additional, Maihofer, Adam X., additional, Nievergelt, Caroline M., additional, Larsson, Henrik, additional, Mattheisen, Manuel, additional, Polimanti, Renato, additional, Meier, Sandra M., additional, Choi, Karmel W., additional, Coleman, Jonathan R.I., additional, Daskalakis, Nikolaos P., additional, Denckla, Christy A., additional, Ketema, Elizabeth, additional, Morey, Rajendra A., additional, Ratanatharathorn, Andrew, additional, Torres, Katy, additional, Wingo, Aliza P., additional, Zai, Clement C., additional, Aiello, Allison E., additional, Almli, Lynn M., additional, Amstadter, Ananda B., additional, Andersen, Soren B., additional, Andreassen, Ole A., additional, Arbisi, Paul A., additional, Ashley-Koch, Allison E., additional, Austin, S. Bryn, additional, Avdibegovic, Esmina, additional, Borglum, Anders D., additional, Babic, Dragan, additional, Bækvad-Hansen, Marie, additional, Baker, Dewleen G., additional, Beckham, Jean C., additional, Bierut, Laura J., additional, Bisson, Jonathan I., additional, Boks, Marco P., additional, Bolger, Elizabeth A., additional, Bradley, Bekh, additional, Brashear, Meghan, additional, Breen, Gerome, additional, Bryant, Richard A., additional, Bustamante, Angela C., additional, Bybjerg-Grauholm, Jonas, additional, Calabrese, Joseph R., additional, Caldas-de-Almeida, Jose Miguel, additional, Chen, Chia-Yen, additional, Dale, Anders M., additional, Dalvie, Shareefa, additional, Deckert, Jürgen, additional, Delahanty, Douglas L., additional, Dennis, Michelle F., additional, Disner, Seth G., additional, Domschke, Katharina, additional, Duncan, Laramie E., additional, Kulenovic, Alma Dzubur, additional, Erbes, Christopher R., additional, Evans, Alexandra, additional, Farrer, Lindsay A., additional, Feeny, Norah C., additional, Flory, Janine D., additional, Forbes, David, additional, Franz, Carol E., additional, Galea, Sandro, additional, Garrett, Melanie E., additional, Gautam, Aarti, additional, Gelaye, Bizu, additional, Geuze, Elbert, additional, Gillespie, Charles F., additional, Uka, Aferdita Goci, additional, Gordon, Scott D., additional, Guffanti, Guia, additional, Hammamieh, Rasha, additional, Hauser, Michael A., additional, Heath, Andrew C., additional, Hemmings, Sian M.J., additional, Hougaard, David Michael, additional, Jakovljevic, Miro, additional, Jett, Marti, additional, Johnson, Eric Otto, additional, Jones, Ian, additional, Jovanovic, Tanja, additional, Qin, Xue-Jun, additional, Karstoft, Karen-Inge, additional, Kaufman, Milissa L., additional, Kessler, Ronald C., additional, Khan, Alaptagin, additional, Kimbrel, Nathan A., additional, King, Anthony P., additional, Koen, Nastassja, additional, Kranzler, Henry R., additional, Kremen, William S., additional, Lawford, Bruce R., additional, Lebois, Lauren A.M., additional, Lewis, Catrin, additional, Liberzon, Israel, additional, Linnstaedt, Sarah D., additional, Logue, Mark W., additional, Lori, Adriana, additional, Lugonja, Bozo, additional, Luykx, Jurjen J., additional, Lyons, Michael J., additional, Maples-Keller, Jessica L., additional, Marmar, Charles, additional, Martin, Nicholas G., additional, Maurer, Douglas, additional, Mavissakalian, Matig R., additional, McFarlane, Alexander, additional, McGlinchey, Regina E., additional, McLaughlin, Katie A., additional, McLean, Samuel A., additional, Mehta, Divya, additional, Mellor, Rebecca, additional, Michopoulos, Vasiliki, additional, Milberg, William, additional, Miller, Mark W., additional, Morris, Charles Phillip, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Nelson, Elliot C., additional, Nordentoft, Merete, additional, Norman, Sonya B., additional, O’Donnell, Meaghan, additional, Orcutt, Holly K., additional, Panizzon, Matthew S., additional, Peters, Edward S., additional, Peterson, Alan L., additional, Peverill, Matthew, additional, Pietrzak, Robert H., additional, Polusny, Melissa A., additional, Rice, John P., additional, Risbrough, Victoria B., additional, Roberts, Andrea L., additional, Rothbaum, Alex O., additional, Rothbaum, Barbara O., additional, Roy-Byrne, Peter, additional, Ruggiero, Kenneth J., additional, Rung, Ariane, additional, Rutten, Bart P.F., additional, Saccone, Nancy L., additional, Sanchez, Sixto E., additional, Schijven, Dick, additional, Seedat, Soraya, additional, Seligowski, Antonia V., additional, Seng, Julia S., additional, Sheerin, Christina M., additional, Silove, Derrick, additional, Smith, Alicia K., additional, Smoller, Jordan W., additional, Sponheim, Scott R., additional, Stein, Dan J., additional, Stevens, Jennifer S., additional, Teicher, Martin H., additional, Thompson, Wesley K., additional, Trapido, Edward, additional, Uddin, Monica, additional, Ursano, Robert J., additional, Luella van den Heuvel, Leigh, additional, Van Hooff, Miranda, additional, Vermetten, Eric, additional, Vinkers, Christiaan, additional, Voisey, Joanne, additional, Wang, Yunpeng, additional, Wang, Zhewu, additional, Werge, Thomas, additional, Williams, Michelle A., additional, Williamson, Douglas E., additional, Winternitz, Sherry, additional, Wolf, Christiane, additional, Wolf, Erika J., additional, Yehuda, Rachel, additional, Young, Keith A., additional, Young, Ross McD., additional, Zhao, Hongyu, additional, Zoellner, Lori A., additional, Haas, Magali, additional, Lasseter, Heather, additional, Provost, Allison C., additional, Salem, Rany M., additional, Sebat, Jonathan, additional, Shaffer, Richard, additional, Wu, Tianying, additional, Ripke, Stephan, additional, Daly, Mark J., additional, Ressler, Kerry J., additional, and Koenen, Karestan C., additional

Published
2023
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78. Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium

Author

Kennedy, Eamonn, primary, Vadlamani, Shashank, additional, Lindsey, Hannah M, additional, Lei, Pui-Wa, additional, Jo-Pugh, Mary, additional, Adamson, Maheen, additional, Alda, Martin, additional, Alonso-Lana, Silvia, additional, Ambrogi, Sonia, additional, Anderson, Tim J, additional, Arango, Celso, additional, Asarnow, Robert F, additional, Avram, Mihai, additional, Ayesa-Arriola, Rosa, additional, Babikian, Talin, additional, Banaj, Nerisa, additional, Bird, Laura J, additional, Borgwardt, Stefan, additional, Brodtmann, Amy, additional, Brosch, Katharina, additional, Caeyenberghs, Karen, additional, Calhoun, Vince D, additional, Chiaravalloti, Nancy D, additional, Cifu, David X, additional, Crespo-Facorro, Benedicto, additional, Dalrymple-Alford, John C, additional, Dams-O’Connor, Kristen, additional, Dannlowski, Udo, additional, Darby, David, additional, Davenport, Nicholas, additional, DeLuca, John, additional, Diaz-Caneja, Covadonga M, additional, Disner, Seth G, additional, Dobryakova, Ekaterina, additional, Ehrlich, Stefan, additional, Esopenko, Carrie, additional, Ferrarelli, Fabio, additional, Frank, Lea E, additional, Franz, Carol, additional, Fuentes-Claramonte, Paola, additional, Genova, Helen, additional, Giza, Christopher C, additional, Goltermann, Janik, additional, Grotegerd, Dominik, additional, Gruber, Marius, additional, Gutierrez-Zotes, Alfonso, additional, Ha, Minji, additional, Haavik, Jan, additional, Hinkin, Charles, additional, Hoskinson, Kristen R, additional, Hubl, Daniela, additional, Irimia, Andrei, additional, Jansen, Andreas, additional, Kaess, Michael, additional, Kang, Xiaojian, additional, Kenney, Kimbra, additional, Keřková, Barbora, additional, Khlif, Mohamed Salah, additional, Kim, Minah, additional, Kindler, Jochen, additional, Kircher, Tilo, additional, Knížková, Karolina, additional, Kolskår, Knut K, additional, Krch, Denise, additional, Kremen, William S, additional, Kuhn, Taylor, additional, Kumari, Veena, additional, Kwon, Jun Soo, additional, Langella, Roberto, additional, Laskowitz, Sarah, additional, Lee, Jungha, additional, Lengenfelder, Jean, additional, Liebel, Spencer W, additional, Liou-Johnson, Victoria, additional, Lippa, Sara M, additional, Løvstad, Marianne, additional, Lundervold, Astri, additional, Marotta, Cassandra, additional, Marquardt, Craig A, additional, Mattos, Paulo, additional, Mayeli, Ahmad, additional, McDonald, Carrie R, additional, Meinert, Susanne, additional, Melzer, Tracy R, additional, Merchán-Naranjo, Jessica, additional, Michel, Chantal, additional, Morey, Rajendra A, additional, Mwangi, Benson, additional, Myall, Daniel J, additional, Nenadić, Igor, additional, Newsome, Mary R, additional, Nunes, Abraham, additional, O’Brien, Terence, additional, Oertel, Viola, additional, Ollinger, John, additional, Olsen, Alexander, additional, de la Foz, Victor Ortiz García, additional, Ozmen, Mustafa, additional, Pardoe, Heath, additional, Parent, Marise, additional, Piras, Fabrizio, additional, Piras, Federica, additional, Pomarol-Clotet, Edith, additional, Repple, Jonathan, additional, Richard, Geneviève, additional, Rodriguez, Jonathan, additional, Rodriguez, Mabel, additional, Rootes-Murdy, Kelly, additional, Rowland, Jared, additional, Ryan, Nicholas P, additional, Salvador, Raymond, additional, Sanders, Anne-Marthe, additional, Schmidt, Andre, additional, Soares, Jair C, additional, Spalleta, Gianfranco, additional, Španiel, Filip, additional, Stasenko, Alena, additional, Stein, Frederike, additional, Straube, Benjamin, additional, Thames, April, additional, Thomas-Odenthal, Florian, additional, Thomopoulos, Sophia I, additional, Tone, Erin, additional, Torres, Ivan, additional, Troyanskaya, Maya, additional, Turner, Jessica A, additional, Ulrichsen, Kristine M, additional, Umpierrez, Guillermo, additional, Vilella, Elisabet, additional, Vivash, Lucy, additional, Walker, William C, additional, Werden, Emilio, additional, Westlye, Lars T, additional, Wild, Krista, additional, Wroblewski, Adrian, additional, Wu, Mon-Ju, additional, Wylie, Glenn R, additional, Yatham, Lakshmi N, additional, Zunta-Soares, Giovana B, additional, Thompson, Paul M, additional, Tate, David F, additional, Hillary, Frank G, additional, Dennis, Emily L, additional, and Wilde, Elisabeth A, additional

Published
2023
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80. Altered lateralization of the cingulum in deployment‐related traumatic brain injury: An ENIGMA military‐relevant brain injury study

Author

Dennis, Emily L., primary, Newsome, Mary R., additional, Lindsey, Hannah M., additional, Adamson, Maheen, additional, Austin, Tara A., additional, Disner, Seth G., additional, Eapen, Blessen C., additional, Esopenko, Carrie, additional, Franz, Carol E., additional, Geuze, Elbert, additional, Haswell, Courtney, additional, Hinds, Sidney R., additional, Hodges, Cooper B., additional, Irimia, Andrei, additional, Kenney, Kimbra, additional, Koerte, Inga K., additional, Kremen, William S., additional, Levin, Harvey S., additional, Morey, Rajendra A., additional, Ollinger, John, additional, Rowland, Jared A., additional, Scheibel, Randall S., additional, Shenton, Martha E., additional, Sullivan, Danielle R., additional, Talbert, Leah D., additional, Thomopoulos, Sophia I., additional, Troyanskaya, Maya, additional, Walker, William C., additional, Wang, Xin, additional, Ware, Ashley L., additional, Werner, John Kent, additional, Williams, Wright, additional, Thompson, Paul M., additional, Tate, David F., additional, and Wilde, Elisabeth A., additional

Published
2022
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81. Multimodal Imaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium

Author

Zhu, Xi, primary, Kim, Yoojean, additional, Ravid, Orren, additional, He, Xiaofu, additional, Suarez-Jimenez, Benjamin, additional, Zilcha-Mano, Sigal, additional, Lazarov, Amit, additional, Lee, Seonjoo, additional, Abdallah, Chadi G., additional, Angstadt, Michael, additional, Averill, Christopher L., additional, Baird, C. Lexi, additional, Baugh, Lee A., additional, Blackford, Jennifer U., additional, Bomyea, Jessica, additional, Bruce, Steven E., additional, Bryant, Richard A., additional, Cao, Zhihong, additional, Choi, Kyle, additional, Cisler, Josh, additional, Cotton, Andrew S., additional, Daniels, Judith K., additional, Davenport, Nicholas D., additional, Davidson, Richard J., additional, DeBellis, Michael D., additional, Dennis, Emily L., additional, Densmore, Maria, additional, deRoon-Cassini, Terri, additional, Disner, Seth G., additional, Hage, Wissam El, additional, Etkin, Amit, additional, Fani, Negar, additional, Fercho, Kelene A., additional, Fitzgerald, Jacklynn, additional, Forster, Gina L., additional, Frijling, Jessie L., additional, Geuze, Elbert, additional, Gonenc, Atilla, additional, Gordon, Evan M., additional, Gruber, Staci, additional, Grupe, Daniel W, additional, Guenette, Jeffrey P., additional, Haswell, Courtney C., additional, Herringa, Ryan J., additional, Herzog, Julia, additional, Hofmann, David Bernd, additional, Hosseini, Bobak, additional, Hudson, Anna R., additional, Huggins, Ashley A., additional, Ipser, Jonathan C., additional, Jahanshad, Neda, additional, Jia-Richards, Meilin, additional, Jovanovic, Tanja, additional, Kaufman, Milissa L., additional, Kennis, Mitzy, additional, King, Anthony, additional, Kinzel, Philipp, additional, Koch, Saskia B. J., additional, Koerte, Inga K., additional, Koopowitz, Sheri M., additional, Korgaonkar, Mayuresh S., additional, Krystal, John H., additional, Lanius, Ruth, additional, Larson, Christine L., additional, Lebois, Lauren A. M., additional, Li, Gen, additional, Liberzon, Israel, additional, Lu, Guang Ming, additional, Luo, Yifeng, additional, Magnotta, Vincent A., additional, Manthey, Antje, additional, Maron-Katz, Adi, additional, May, Geoffery, additional, McLaughlin, Katie, additional, Mueller, Sven C., additional, Nawijn, Laura, additional, Nelson, Steven M., additional, Neufeld, Richard W.J., additional, Nitschke, Jack B, additional, O’Leary, Erin M., additional, Olatunji, Bunmi O., additional, Olff, Miranda, additional, Peverill, Matthew, additional, Phan, K. Luan, additional, Qi, Rongfeng, additional, Quidé, Yann, additional, Rektor, Ivan, additional, Ressler, Kerry, additional, Riha, Pavel, additional, Ross, Marisa, additional, Rosso, Isabelle M., additional, Salminen, Lauren E., additional, Sambrook, Kelly, additional, Schmahl, Christian, additional, Shenton, Martha E., additional, Sheridan, Margaret, additional, Shih, Chiahao, additional, Sicorello, Maurizio, additional, Sierk, Anika, additional, Simmons, Alan N., additional, Simons, Raluca M., additional, Simons, Jeffrey S., additional, Sponheim, Scott R., additional, Stein, Murray B., additional, Stein, Dan J., additional, Stevens, Jennifer S., additional, Straube, Thomas, additional, Sun, Delin, additional, Théberge, Jean, additional, Thompson, Paul M., additional, Thomopoulos, Sophia I., additional, van der Wee, Nic J.A., additional, van der Werff, Steven J.A., additional, van Erp, Theo G. M., additional, van Rooij, Sanne J. H., additional, van Zuiden, Mirjam, additional, Varkevisser, Tim, additional, Veltman, Dick J., additional, Vermeiren, Robert R.J.M., additional, Walter, Henrik, additional, Wang, Li, additional, Wang, Xin, additional, Weis, Carissa, additional, Winternitz, Sherry, additional, Xie, Hong, additional, Zhu, Ye, additional, Wall, Melanie, additional, Neria, Yuval, additional, and Morey, Rajendra A., additional

Published
2022
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84. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results from the ENIGMA-PGC PTSD Consortium

Author

Sun, Delin, Rakesh, Gopalkumar, Clarke-Rubright, Emily K, Haswell, Courtney C, Logue, Mark, O'Leary, Erin N, Cotton, Andrew S, Xie, Hong, Dennis, Emily L, Jahanshad, Neda, Salminen, Lauren E, Thomopoulos, Sophia I, Rashid, Faisal, Ching, Christopher R K, Koch, Saskia B J, Frijling, Jessie L, Nawijn, Laura, van Zuiden, Mirjam, Zhu, Xi, Suarez-Jimenez, Benjamin, Sierk, Anika, Walter, Henrik, Manthey, Antje, Stevens, Jennifer S, Fani, Negar, van Rooij, Sanne J H, Stein, Murray, Bomyea, Jessica, Koerte, Inga, Choi, Kyle, van de Werff, Steven J A, Vermeiren, Robert R J M, Herzog, Julia, Lebois, Lauren A M, Baker, Justin T, Ressler, Kerry J, Olson, Elizabeth A, Straube, Thomas, Korgaonkar, Mayuresh S, Andrew, Elpiniki, Zhu, Ye, Li, Gen, Ipser, Jonathan, Hudson, Anna, Peverill, Matthew, Sambrook, Kelly, Gordon, Evan, Baugh, Lee, Forster, Gina, Simons, Raluca, Simons, Jeffrey, Magnotta, Vincent, Maron-Katz, Adi, du Plessis, Stefan, Disner, Seth, Davenport, Nicholas, Grupe, Dan, Nitschke, Jack, deRoon-Cassini, Terri A, Fitzgerald, Jacklynn, Krystal, John H, Levy, Ifat, Olff, Miranda, Veltman, Dick J, Wang, Li, Neria, Yuval, De Bellis, Michael D, Jovanovic, Tanja, Daniels, Judith K, Shenton, Martha, van de Wee, Nic J A, Schmahl, Christian, Kaufman, Milissa L, Rosso, Isabelle M, Sponheim, Scott R, Hofmann, David Bernd, Bryant, Richard A, Fercho, Kelene A, Stein, Dan J, Mueller, Sven C, Phan, Luan, McLaughlin, Katie A, Davidson, Richard J, Larson, Christine, May, Geoffrey, Nelson, Steven M, Abdallah, Chadi G, Gomaa, Hassaan, Etkin, Amit, Seedat, Soraya, Harpaz-Rotem, Ilan, Liberzon, Israel, Wang, Xin, Thompson, Paul M, Morey, Rajendra A, and Clinical Psychology and Experimental Psychopathology

Abstract

BACKGROUND: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA). METHODS: Neuroimaging and clinical data were aggregated from 29 research sites in >1,300 PTSD cases and >2,000 trauma-exposed controls (age 6.2-85.2 years) by the ENIGMA-PGC PTSD working group. Cortical regions in the network were rank-ordered by effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2 to 148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared to the mean SC of 5,000 randomly generated n-region networks. RESULTS: Patients with PTSD, relative to non-PTSD controls, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex and age modulated covariance differences of PTSD-related structural networks. CONCLUSIONS: Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The structural covariance networks that are perturbed in PTSD comport with converging evidence from resting state functional connectivity networks and networks impacted by inflammatory processes, and stress hormones in PTSD.

Published
2022

85. Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture

Author

Morey, Rajendra A., primary, Zheng, Yuanchao, additional, Sun, Delin, additional, Garrett, Melanie E., additional, Gasperi, Marianna, additional, Maihofer, Adam X., additional, Baird, Lexi, additional, Grasby, Katrina L., additional, Huggins, Ashley, additional, Haswell, Courtney C., additional, Thompson, C. Paul M., additional, Medland, Sarah, additional, Gustavson, Daniel E., additional, Panizzon, Matthew S., additional, Kremen, William S., additional, Nievergelt, Caroline M., additional, Ashley-Koch, Allison E., additional, and Logue, Mark W., additional

Published
2022
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86. A comparison of methods to harmonize cortical thickness measurements across scanners and sites

Author

Sun, Delin, primary, Rakesh, Gopalkumar, additional, Haswell, Courtney C., additional, Logue, Mark, additional, Baird, C. Lexi, additional, O'Leary, Erin N., additional, Cotton, Andrew S., additional, Xie, Hong, additional, Tamburrino, Marijo, additional, Chen, Tian, additional, Dennis, Emily L., additional, Jahanshad, Neda, additional, Salminen, Lauren E., additional, Thomopoulos, Sophia I., additional, Rashid, Faisal, additional, Ching, Christopher R.K., additional, Koch, Saskia B.J., additional, Frijling, Jessie L., additional, Nawijn, Laura, additional, van Zuiden, Mirjam, additional, Zhu, Xi, additional, Suarez-Jimenez, Benjamin, additional, Sierk, Anika, additional, Walter, Henrik, additional, Manthey, Antje, additional, Stevens, Jennifer S., additional, Fani, Negar, additional, van Rooij, Sanne J.H., additional, Stein, Murray, additional, Bomyea, Jessica, additional, Koerte, Inga K., additional, Choi, Kyle, additional, van der Werff, Steven J.A., additional, Vermeiren, Robert R.J.M., additional, Herzog, Julia, additional, Lebois, Lauren A.M., additional, Baker, Justin T., additional, Olson, Elizabeth A., additional, Straube, Thomas, additional, Korgaonkar, Mayuresh S., additional, Andrew, Elpiniki, additional, Zhu, Ye, additional, Li, Gen, additional, Ipser, Jonathan, additional, Hudson, Anna R., additional, Peverill, Matthew, additional, Sambrook, Kelly, additional, Gordon, Evan, additional, Baugh, Lee, additional, Forster, Gina, additional, Simons, Raluca M., additional, Simons, Jeffrey S., additional, Magnotta, Vincent, additional, Maron-Katz, Adi, additional, du Plessis, Stefan, additional, Disner, Seth G., additional, Davenport, Nicholas, additional, Grupe, Daniel W., additional, Nitschke, Jack B., additional, deRoon-Cassini, Terri A., additional, Fitzgerald, Jacklynn M., additional, Krystal, John H., additional, Levy, Ifat, additional, Olff, Miranda, additional, Veltman, Dick J., additional, Wang, Li, additional, Neria, Yuval, additional, De Bellis, Michael D., additional, Jovanovic, Tanja, additional, Daniels, Judith K., additional, Shenton, Martha, additional, van de Wee, Nic J.A., additional, Schmahl, Christian, additional, Kaufman, Milissa L., additional, Rosso, Isabelle M., additional, Sponheim, Scott R., additional, Hofmann, David Bernd, additional, Bryant, Richard A., additional, Fercho, Kelene A., additional, Stein, Dan J., additional, Mueller, Sven C., additional, Hosseini, Bobak, additional, Phan, K. Luan, additional, McLaughlin, Katie A., additional, Davidson, Richard J., additional, Larson, Christine L., additional, May, Geoffrey, additional, Nelson, Steven M., additional, Abdallah, Chadi G., additional, Gomaa, Hassaan, additional, Etkin, Amit, additional, Seedat, Soraya, additional, Harpaz-Rotem, Ilan, additional, Liberzon, Israel, additional, van Erp, Theo G.M., additional, Quidé, Yann, additional, Wang, Xin, additional, Thompson, Paul M., additional, and Morey, Rajendra A., additional

Published
2022
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87. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Author

Huggins, Ashley A., primary, Baird, C. Lexi, additional, Briggs, Melvin, additional, Laskowitz, Sarah, additional, Foudra, Samar, additional, Haswell, Courtney, additional, Sun, Delin, additional, Salminen, Lauren E., additional, Jahanshad, Neda, additional, Thomopoulos, Sophia I., additional, Veltman, Dick J., additional, Frijling, Jessie L., additional, Olff, Miranda, additional, van Zuiden, Mirjam, additional, Koch, Saskia B.J., additional, Nawjin, Laura, additional, Wang, Li, additional, Zhu, Ye, additional, Li, Gen, additional, Stein, Dan J., additional, Ipser, Johnathan, additional, Seedat, Soraya, additional, du Plessis, Stefan, additional, van den Heuvel, Leigh L., additional, Suarez-Jimenez, Benjamin, additional, Zhu, Xi, additional, Kim, Yoojean, additional, He, Xiaofu, additional, Zilcha-Mano, Sigal, additional, Lazarov, Amit, additional, Neria, Yuval, additional, Stevens, Jennifer S., additional, Ressler, Kerry J., additional, Jovanovic, Tanja, additional, van Rooij, Sanne JH, additional, Fani, Negar, additional, Hudson, Anna R., additional, Mueller, Sven C., additional, Sierk, Anika, additional, Manthey, Antje, additional, Walter, Henrik, additional, Daniels, Judith K., additional, Schmahl, Christian, additional, Herzog, Julia I., additional, Říha, Pavel, additional, Rektor, Ivan, additional, Lebois, Lauren A.M., additional, Kaufman, Milissa L., additional, Olson, Elizabeth A., additional, Baker, Justin T., additional, Rosso, Isabelle M., additional, King, Anthony P., additional, Liberzon, Isreal, additional, Angstadt, Mike, additional, Davenport, Nicholas D., additional, Sponheim, Scott R., additional, Disner, Seth G., additional, Straube, Thomas, additional, Hofmann, David, additional, Qi, Rongfeng, additional, Lu, Guang Ming, additional, Baugh, Lee A., additional, Forster, Gina L., additional, Simons, Raluca M., additional, Simons, Jeffrey S., additional, Magnotta, Vincent A., additional, Fercho, Kelene A., additional, Maron-Katz, Adi, additional, Etkin, Amit, additional, Cotton, Andrew S., additional, O’Leary, Erin N., additional, Xie, Hong, additional, Wang, Xin, additional, Quidé, Yann, additional, El-Hage, Wissam, additional, Lissek, Shmuel, additional, Berg, Hannah, additional, Bruce, Steven, additional, Cisler, Josh, additional, Ross, Marisa, additional, Herringa, Ryan J., additional, Grupe, Daniel W., additional, Nitschke, Jack B., additional, Davidson, Richard J., additional, Larson, Christine, additional, deRoon-Cassini, Terri A., additional, Tomas, Carissa W., additional, Fitzgerald, Jacklynn M., additional, Blackford, Jennifer Urbano, additional, Olatunji, Bunmi O., additional, Kremen, William S., additional, Lyons, Michael J., additional, Franz, Carol E., additional, Gordon, Evan M., additional, May, Geoffrey, additional, Nelson, Steven M., additional, Abdallah, Chadi G., additional, Levy, Ifat, additional, Harpaz-Rotem, Ilan, additional, Krystal, John H., additional, Dennis, Emily L., additional, Tate, David F., additional, Cifu, David X., additional, Walker, William C., additional, Wilde, Elizabeth A., additional, Harding, Ian H., additional, Kerestes, Rebecca, additional, Thompson, Paul M., additional, and Morey, Rajendra, additional

Published
2022
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88. Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach

Author

Sun, Delin, primary, Adduru, Viraj R., additional, Phillips, Rachel D., additional, Bouchard, Heather C., additional, Sotiras, Aristeidis, additional, Michael, Andrew M., additional, Baker, Fiona C., additional, Tapert, Susan F., additional, Brown, Sandra A., additional, Clark, Duncan B., additional, Goldston, David, additional, Nooner, Kate B., additional, Nagel, Bonnie J., additional, Thompson, Wesley K., additional, De Bellis, Michael D., additional, and Morey, Rajendra A., additional

Published
2022
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89. T84. GENOMIC STRUCTURAL EQUATION MODELING REVEALS LATENT PHENOTYPES IN THE HUMAN CORTEX WITH DISTINCT GENETIC ARCHITECTURE

Author

Morey, Rajendra, primary, Zheng, Yuanchao, additional, Sun, Delin, additional, Garrett, Melanie E., additional, Gasperi, Mariana, additional, Haswell, Courtney C., additional, Baird, C. Lexi, additional, Maihofer, Adam X., additional, Grasby, Katrina, additional, Medland, Sarah L., additional, Nievergelt, Caroline N., additional, Gustafson, Daniel L., additional, Thompson, Paul M., additional, Ashley-Koch, Allison E., additional, and Logue, Mark W., additional

Published
2022
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90. Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury.

Author

Siddiqi, Shan H., Kandala, Sridhar, Hacker, Carl D., Bouchard, Heather, Leuthardt, Eric C., Corbetta, Maurizio, Morey, Rajendra A., and Brody, David L.

Abstract

Depression associated with traumatic brain injury (TBI) is believed to be clinically distinct from primary major depressive disorder (MDD) and may be less responsive to conventional treatments. Brain connectivity differences between the dorsal attention network (DAN), default mode network (DMN), and subgenual cingulate have been implicated in TBI and MDD. To characterize these distinctions, we applied precision functional mapping of brain network connectivity to resting-state functional magnetic resonance imaging data from five published patient cohorts, four discovery cohorts (n = 93), and one replication cohort (n = 180). We identified a distinct brain connectivity profile in TBI-associated depression that was independent of TBI, MDD, posttraumatic stress disorder (PTSD), depression severity, and cohort. TBI-associated depression was independently associated with decreased DAN–subgenual cingulate connectivity, increased DAN-DMN connectivity, and the combined effect of both. This effect was stronger when using precision functional mapping relative to group-level network maps. Our results support the possibility of a physiologically distinct "TBI affective syndrome," which may benefit from individualized neuromodulation approaches to target its distinct neural circuitry. Editor's summary: Depression associated with traumatic brain injury (TBI) is thought to be distinct from major depression and to be less amenable to treatment. Siddiqi and colleagues now use precision fMRI brain mapping to elucidate a distinct brain connectivity pattern in patients with TBI-associated depression. This connectivity pattern was distinct from connectivity patterns observed in patients with depression alone or TBI alone. This suggested that TBI-associated depression could be a distinct clinical entity for which the authors propose the name "TBI affective syndrome." —Orla Smith [ABSTRACT FROM AUTHOR]

Published
2023
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92. Harmonizing PTSD severity scales across instruments and sites.

Author

Kennedy, Eamonn, primary, Dennis, Emily L., additional, Lindsey, Hannah M., additional, deRoon-Cassini, Terri, additional, Du Plessis, Stefan, additional, Fani, Negar, additional, Kaufman, Milissa L., additional, Koen, Nastassja, additional, Larson, Christine L., additional, Laskowitz, Sarah, additional, Lebois, Lauren A. M., additional, Morey, Rajendra A., additional, Newsome, Mary R., additional, Palermo, Cori, additional, Pastorek, Nicholas J., additional, Powers, Abigail, additional, Scheibel, Randall, additional, Seedat, Soraya, additional, Seligowski, Antonia, additional, Stein, Dan J., additional, Stevens, Jennifer, additional, Sun, Delin, additional, Thompson, Paul, additional, Troyanskaya, Maya, additional, van Rooij, Sanne J. H., additional, Watts, Amanda A., additional, Tomas, Carissa W., additional, Williams, Wright, additional, Hillary, Frank G., additional, Pugh, Mary Jo, additional, Wilde, Elisabeth A., additional, and Tate, David F., additional

Published
2022
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93. Enhancing discovery of genetic variants for posttraumatic stress disorder through integration of quantitative phenotypes and trauma exposure information

Author

Maihofer, Adam X., Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Polimanti, Renato, Ratanatharathorn, Andrew, Torres, Katy, and Show all

Subjects
Heritability, PheWAS, Genetics, GWAS, PTSD, Trauma
Abstract

Background: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). Methods: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. Results: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. Conclusions: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods. © 2021 Society of Biological Psychiatry

Published
2022

95. ENIGMA HALFpipe:Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data

Author

Waller, Lea, Erk, Susanne, Pozzi, Elena, Toenders, Yara J, Haswell, Courtney C, Büttner, Marc, Thompson, Paul M, Schmaal, Lianne, Morey, Rajendra A, Walter, Henrik, Veer, Ilya M, Waller, Lea, Erk, Susanne, Pozzi, Elena, Toenders, Yara J, Haswell, Courtney C, Büttner, Marc, Thompson, Paul M, Schmaal, Lianne, Morey, Rajendra A, Walter, Henrik, and Veer, Ilya M

Abstract

The reproducibility crisis in neuroimaging has led to an increased demand for standardized data processing workflows. Within the ENIGMA consortium, we developed HALFpipe (Harmonized Analysis of Functional MRI pipeline), an open-source, containerized, user-friendly tool that facilitates reproducible analysis of task-based and resting-state fMRI data through uniform application of preprocessing, quality assessment, single-subject feature extraction, and group-level statistics. It provides state-of-the-art preprocessing using fMRIPrep without the requirement for input data in Brain Imaging Data Structure (BIDS) format. HALFpipe extends the functionality of fMRIPrep with additional preprocessing steps, which include spatial smoothing, grand mean scaling, temporal filtering, and confound regression. HALFpipe generates an interactive quality assessment (QA) webpage to rate the quality of key preprocessing outputs and raw data in general. HALFpipe features myriad post-processing functions at the individual subject level, including calculation of task-based activation, seed-based connectivity, network-template (or dual) regression, atlas-based functional connectivity matrices, regional homogeneity (ReHo), and fractional amplitude of low-frequency fluctuations (fALFF), offering support to evaluate a combinatorial number of features or preprocessing settings in one run. Finally, flexible factorial models can be defined for mixed-effects regression analysis at the group level, including multiple comparison correction. Here, we introduce the theoretical framework in which HALFpipe was developed, and present an overview of the main functions of the pipeline. HALFpipe offers the scientific community a major advance toward addressing the reproducibility crisis in neuroimaging, providing a workflow that encompasses preprocessing, post-processing, and QA of fMRI data, while broadening core principles of data analysis for producing reproducible results. Instructions and code can b

Published
2022

96. Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury

Author

MGGZ, Brain, Cardiologie, Bouchard, Heather C., Sun, Delin, Dennis, Emily L., Newsome, Mary R., Disner, Seth G., Elman, Jeremy, Silva, Annelise, Velez, Carmen, Irimia, Andrei, Davenport, Nicholas D., Sponheim, Scott R., Franz, Carol E., Kremen, William S., Coleman, Michael J., Williams, M. Wright, Geuze, Elbert, Koerte, Inga K., Shenton, Martha E., Adamson, Maheen M., Coimbra, Raul, Grant, Gerald, Shutter, Lori, George, Mark S., Zafonte, Ross D., McAllister, Thomas W., Stein, Murray B., Thompson, Paul M., Wilde, Elisabeth A., Tate, David F., Sotiras, Aristeidis, Morey, Rajendra A., MGGZ, Brain, Cardiologie, Bouchard, Heather C., Sun, Delin, Dennis, Emily L., Newsome, Mary R., Disner, Seth G., Elman, Jeremy, Silva, Annelise, Velez, Carmen, Irimia, Andrei, Davenport, Nicholas D., Sponheim, Scott R., Franz, Carol E., Kremen, William S., Coleman, Michael J., Williams, M. Wright, Geuze, Elbert, Koerte, Inga K., Shenton, Martha E., Adamson, Maheen M., Coimbra, Raul, Grant, Gerald, Shutter, Lori, George, Mark S., Zafonte, Ross D., McAllister, Thomas W., Stein, Murray B., Thompson, Paul M., Wilde, Elisabeth A., Tate, David F., Sotiras, Aristeidis, and Morey, Rajendra A.

Published
2022

98. Altered Lateralization of the Cingulum in Deployment-Related Traumatic Brain Injury: An ENIGMA Military-Relevant Brain Injury Study

Author

Dennis, Emily L, primary, Newsome, Mary R, additional, Lindsey, Hannah M, additional, Adams, Maheen M, additional, Austin, Tara A, additional, Disner, Seth G, additional, Eapen, Blessen C, additional, Esopenko, Carrie, additional, Franz, Carol E, additional, Geuze, Elbert, additional, Haswell, Courtney, additional, Hinds, Sidney R, additional, Hodges, Cooper B, additional, Irimia, Andrei, additional, Kenney, Kimbra, additional, Koerte, Inga K, additional, Kremen, William S, additional, Levin, Harvey S, additional, Morey, Rajendra A, additional, Ollinger, John, additional, Rowland, Jared A, additional, Scheibel, Randall S, additional, Shenton, Martha E, additional, Sullivan, Danielle R, additional, Talbert, Leah D, additional, Thomopoulos, Sophia I, additional, Troyanskaya, Maya, additional, Walker, William C, additional, Wang, Xin, additional, Ware, Ashley L, additional, Werner, J Kent, additional, Williams, Wright, additional, Thompson, Paul M, additional, Tate, David F, additional, and Wilde, Elisabeth A, additional

Published
2022
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100. Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach

Author

Bountress, Kaitlin E., primary, Brick, Leslie A., additional, Sheerin, Christina, additional, Grotzinger, Andrew, additional, Bustamante, Daniel, additional, Hawn, Sage E., additional, Gillespie, Nathan, additional, Kirkpatrick, Robert M., additional, Kranzler, Henry, additional, Morey, Rajendra, additional, Edenberg, Howard J., additional, Maihofer, Adam X., additional, Disner, Seth, additional, Ashley-Koch, Allison, additional, Peterson, Roseann, additional, Lori, Adriana, additional, Stein, Dan J., additional, Kimbrel, Nathan, additional, Nievergelt, Caroline, additional, Andreassen, Ole A., additional, Luykx, Jurjen, additional, Javanbakht, Arash, additional, Youssef, Nagy A., additional, and Amstadter, Ananda B., additional

Published
2022
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