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225 results on '"Mormile, Mauro"'

51. Familial outbreak of disseminated multi-drug resistant tuberculosis and meningitis

Author

SOFIA, MATTEO, MOLINO, ANTONIO, MORMILE, MAURO, M. Maniscalco, N. Honorè, B. Heym, S.t. Cole, Sofia, Matteo, Maniscalco, M., Honorè, N., Molino, Antonio, Mormile, Mauro, Heym, B., and Cole, S. t.

Abstract

Rapidly progressive multidrug-resistant tuberculosis (MDR-TB) is well documented in human immunodeficiency virus (HIV) positive subjects, but it is not fully recognised in HIV-negative subjects in the familial environment. We report three cases of MDR-TB in three young HIV-negative subjects from the same family. All the patients showed signs of meningitis during the course of their disease, and in two cases a resistant strain of Mycobacterium tuberculosis was isolated in cerebrospinal fluid. Two of the three subjects died from neurological complications; the other was successful treated utilising both systemic and intrathecal therapy for tuberculous meningitis. By a retrospective analysis of DNA obtained from Löwenstein-Jensen cultures, the strains were confirmed as M. tuberculosis resistant to rifampicin and isoniazid, and were closely related in the two cases where specimens were available for analysis. The resistance was acquired in two patients initially infected with a susceptible strain; in the other patient, the resistance was present on the first sensitivity test for which results were available. This report demonstrates the high risk of fatality from MDR-TB for HIV-negative subjects in the absence of reliable early diagnostic and preventive tools. It also reinforces the concept that genetic susceptibility to M. tuberculosis may be an important factor in the clinical presentation and outcome of MDR-TB.

Published
2001

66. Diagnosi intrauterina di malformazione polmonare cistica

Author

MOLINO, ANTONIO, MORMILE, MAURO, STANZIOLA, ANNA AGNESE, SOFIA, MATTEO, B. Balzano, F. De Falco, A. Di Meglio, Molino, Antonio, Mormile, Mauro, Stanziola, ANNA AGNESE, B., Balzano, F., De Falco, A., Di Meglio, and Sofia, Matteo

Published
1998

68. Role of Endothelin in acute and chronic pulmonary disease

Author

SOFIA, MATTEO, MORMILE, MAURO, S. Faraone, M. Maniscalco, M. Alifano, A. Micco, P. Carratù, L. Carratù, A. Fabbrini, V. Santiemma, Sofia, Matteo, Mormile, Mauro, Faraone, S., Maniscalco, M., Alifano, M., Micco, A., Carratù, P., and Carratù, L.

Published
1997

72. [Changes of lung volumes and respiratory muscle strength in patients with growth hormone deficiency]

Author

SOFIA, MATTEO, MEROLA, BARTOLOMEO, MORMILE, MAURO, LOMBARDI, GAETANO, Carratù L., Longobardi S., Stanziola A., MOLINO, ANTONIO, Micco A., Sofia, Matteo, Carratù, L., Merola, Bartolomeo, Mormile, Mauro, Longobardi, S., Stanziola, A., Molino, Antonio, Micco, A., and Lombardi, Gaetano

Subjects
Adult, Male, Growth Hormone, Respiration, Humans, Female, Respiratory Muscles, Muscle Contraction, Respiratory Function Tests
Abstract

The relationship between growth hormone deficiency (GHd) and ventilatory function is not well understood. We studied 7 patients with GHd since childhood who had been adequately treated with replacement therapy until cartilage fusion. Together with 7 well-matched (age and body-type) healthy control subjects, they underwent spirometry including determination of residual volume, and lung diffusing capacity. Also recorded were maximal respiratory muscle pressure during inspiration (PImax) and expiration (PEmax). Patients with GHd showed a significant reduction in total lung capacity and vital capacity while residual volume and lung diffusing capacity remained unchanged. All patients had a significant reduction of both PImax and PEmax. Previously treated adult subjects with GHd present a persistent decrease in lung mobilizing volumes associated with reduced respiratory muscle strength. These alterations may have implications in the management of GHd in adult patients.

Published
1995

73. Endothelin-1 excretion in urine in active pulmonary sarcoidosis and in other interstitial lung diseases

Author

SOFIA, MATTEO, MORMILE, MAURO, S. Faraone, M. Alifano, P. Carratù, L. Carratù, Sofia, Matteo, Mormile, Mauro, S., Faraone, M., Alifano, P., Carratù, and L., Carratù

Subjects
Adult, Male, Sarcoidosis, Pulmonary, Endothelins, Humans, Prednisone, Female, Middle Aged, Lung Diseases, Interstitial, Biomarkers
Abstract

Endothelin-1 (ET-1) is a vasoactive, mitogenic peptide that is variably increased in Bronchoalveolar Lavage Fluid (BALF) and immunohistochemically found in lung tissue of patients with Interstitial Lung Disease (ILD). To assess if endogenous ET-1 production is increased in ILD we evaluated 24 hour (24h) urine excretion of ET-1 in 20 patients with ILD and 10 healthy age-matched controls (HC). Eight patients with active pulmonary sarcoidosis (S), 6 with idiopathic pulmonary fibrosis (IPF) and 6 with focal lung fibrosis due to inactive pulmonary tuberculosis (hTB) were studied. Plasma ET-1 levels (ET-1pl, pg/ml) and 24h ET-1 levels in urine (ET-1ur, ng/24h) were measured by a specific radio-immunoassay. Determinations of ET-1p1 and ET-1ur were repeated in S and IPF patients after 30 days of prednisone (0.75 mg/kg/day) treatment. ET-1p1 concentrations were not different between HC (5.34 +/- 0.48), S (5.95 +/- 0.96), IPF (4.75 +/- 1.37) and hTB (5.97 +/- 1.05) groups. ET-1ur was significantly higher in S (189.50 +/- 60.57) than in HC (69.00 +/- 10.76), IPF (62.17 +/- 19.07) and hTB (82.00 +/- 24.97). After prednisone, ET-1ur in the S group decreased significantly (189.50 +/- 60.57 to 94.00 +/- 13.60), and the decrease paralleled the improved clinical status. In S patients, ET-1ur was not significantly correlated to the degree of respiratory impairment, but it was significantly correlated to the intensity of lymphocytic alveolitis (r = 0.80).(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1995

76. Familial outbreak of multi-drug resistant tuberculosis (MDRT)

Author

SOFIA, MATTEO, MOLINO, ANTONIO, MORMILE, MAURO, STANZIOLA, ANNA AGNESE, F. De Simone, A. Micco, S. Faraone, L. Carratù, Sofia, Matteo, Molino, Antonio, F., De Simone, A., Micco, Mormile, Mauro, Stanziola, ANNA AGNESE, S., Faraone, and L., Carratù

Published
1995

87. A60 antigen as a new tuberculin

Author

SOFIA, MATTEO, MORMILE, MAURO, P. Carratù, S. Faraone, M. Alifano, Sofia, Matteo, Mormile, Mauro, P., Carratù, S., Faraone, and M., Alifano

Published
1993

89. Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung

Author

SOFIA, MATTEO, DEL VECCHIO, SILVANA, MORMILE, MAURO, SALVATORE, MARCO, A. Petrillo, L. Carratu', Sofia, Matteo, DEL VECCHIO, Silvana, A., Petrillo, Mormile, Mauro, Salvatore, Marco, and L., Carratu'

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Pathology, Lung, Lung Neoplasms, medicine.drug_class, business.industry, Radioimmunotherapy, Critical Care and Intensive Care Medicine, Monoclonal antibody, medicine.disease, radiolabeled monoclonal antibodies, medicine.anatomical_structure, Internal medicine, Carcinoma, Non-Small-Cell Lung, medicine, Carcinoma, Humans, In patient, Non small cell, Lung cancer, Cardiology and Cardiovascular Medicine, business, Deposition (chemistry)
Published
1992

94. Changes of clinical parameters and reological properties of sputum during treatment with Nimesulide in patients suffering from chronic bronchitis (a controlled study versus placebo). [Modificazioni dei parametri clinici e delle proprietà reologiche dell'espettorato durante il trattamento con Nimesulide in pazienti affetti da bronchite cronica (studio controllato verso il placebo).]

Author

SOFIA, MATTEO, MOLINO, ANTONIO, MORMILE, MAURO, STANZIOLA, ANNA AGNESE, F. De Simone, I. Scaricabarozzi, L. Carratù, Sofia, Matteo, Molino, Antonio, Mormile, Mauro, Stanziola, ANNA AGNESE, F., De Simone, I., Scaricabarozzi, and L., Carratù

Published
1991

95. Permeabilità bronchiale transepiteliale. Basi funzionali ed implicazioni cliniche

Author

SOFIA, MATTEO, STANZIOLA, ANNA AGNESE, MORMILE, MAURO, MOLINO, ANTONIO, DEL VECCHIO, SILVANA, SALVATORE, MARCO, L. Carratù, F. De Simone, A. Marra, S. Faraone, P. Carratù, M. Alifano, L. Palmieri, R. Battiloro, T. Cautiero, A. Petrillo, Sofia, Matteo, L., Carratù, Stanziola, ANNA AGNESE, Mormile, Mauro, Molino, Antonio, F., De Simone, A., Marra, S., Faraone, P., Carratù, M., Alifano, L., Palmieri, R., Battiloro, T., Cautiero, A., Petrillo, DEL VECCHIO, Silvana, and Salvatore, Marco

Published
1991

97. Evaluation of the efficacy and tolerance of rokitamycin in treating infections of the lower respiratory tract

Author

SOFIA, MATTEO, MOLINO, ANTONIO, STANZIOLA, ANNA AGNESE, MORMILE, MAURO, A. Illiano, F. De Simone, L. Carratu', Sofia, Matteo, Molino, Antonio, Stanziola, ANNA AGNESE, Mormile, Mauro, A., Illiano, F., De Simone, and L., Carratu'

Abstract

A trial was conducted to evaluate the efficacy and tolerance of rokitamycin in 30 patients (23 male, seven female; mean age, 59.9 years ± 1.7 SE) affected by infective disorders of the lower-respiratory tract. Rokitamycin was available in 400-mg tablets; 18 patients were given 800 mg per day, and the remaining 12 were treated with 1,200 mg per day. Treatment lasted between seven and 14 days. The germs that were initially sensitive to rokitamycin were completely eradicated, in particular, four of four Haemophilus influenzae, three of three Streptococcus pneumoniae, two of two Streptococcus pyogenes, three of three Staphylococcus aureus, two of two Staphylococcus epidermidis, and two of two Mycoplasma pneumoniae. The amount of sputum was considerable reduced, and body temperature and erythrocyte sedimentation rate values were also significantly lowered. The pneumology symptomatology was efficiently checked by rokitamycin, which proved to be well tolerated in general. In conclusion, rokitamycin may be considered to be an unfailingly effective and well-tolerated antibiotic for treating patients with infectious disorders of the lower-respiratory tract.

Published
1990

100. Asthma-related deaths.

Author

D'Amato, Gennaro, Vitale, Carolina, Molino, Antonio, Stanziola, Anna, Sanduzzi, Alessandro, Vatrella, Alessandro, Mormile, Mauro, Lanza, Maurizia, Calabrese, Giovanna, Antonicelli, Leonardo, and D'Amato, Maria

Subjects
ASTHMA treatment, ARTIFICIAL respiration, ADRENOCORTICAL hormones, FOOD allergy
Abstract

Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurely each year from asthma. Trends of asthma mortality rates vary very widely across countries, age and ethnic groups. Several risk factors have been associated with asthma mortality, including a history of near-fatal asthma requiring intubation and mechanical ventilation, hospitalization or emergency care visit for asthma in the past year, currently using or having recently stopped using oral corticosteroids (a marker of event severity), not currently using inhaled corticosteroids, a history of psychiatric disease or psychosocial problems, poor adherence with asthma medications and/or poor adherence with (or lack of) a written asthma action plan, food allergy in a patient with asthma. Preventable factors have been identified in the majority of asthma deaths. Inadequate education of patients on recognising risk and the appropriate action needed when asthma control is poor, deficiencies in the accuracy and timing of asthma diagnosis, inadequate classification of severity and treatment, seem to play a part in the majority of asthma deaths. Improvements in management, epitomized by the use of guided self-management systems of care may be the key goals in reducing asthma mortality worldwide. [ABSTRACT FROM AUTHOR]

Published
2016
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