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Recombinant human erythropoietin (rhEPO) has been successfully used for correcting renal anemia. However, recent studies have raised some concerns about the safety of rhEPO treatment due to its immunogenic side effect - pure red cell aplasia (PRCA). We now report a case of development of anti-EPO neutralizing antibodies (Abs) implicated in thrombocytopenia as well as erythrocytopenia. A 35-year-old man had a history of administering rhEPO (epoetin alfa, epoetin beta and darbepoetin alfa) for 2years to treat renal anemia. The hematological parameters were collected. Anti-EPO, anti-platelet, and anti-thrombopoietin (TPO) Ab assays were performed to test the presence of autoreactive Abs. After performing antibody assays due to severe resistance to rhEPO treatment, a high titer of anti-EPO neutralizing Abs was detected. However, unexpectedly, this patient also showed thrombocytopenia rather than PRCA. We investigated the cause of the marked thrombocytopenia and found anti-TPO Abs in patient serum. To our best knowledge, this is the first report of the development of anti-TPO Abs during rhEPO treatment for anemia.

In this paper, we suggest a process called Listener that support so that client can manage easily information retrieval system(IRS) and apply this to KRISTAL-Information Retrieval and Management System(IRMS). Usually, in relational database management system(RDBMS) such as Oracle, there are many applications and tools that client may manage system and its data. On the other hand, in information retrieval system applications for management has been performed in server-side due to the structure and purpose of the IR systems, it is difficult to manage the system. Using the proposed Listener, administrator can achieve control of search daemon process, database structure alteration, data management on client computer. This process has been designed based on XML considering scalability and readability and supports the client API by C and Java and make developer can do easily maintenance of the application for management database.

Objectives: The purpose of this study was to evaluate the effects of oral care interventions on stroke patients in the intensive care unit (ICU). Oral hygiene levels, periodontal health, and presence of Candida were evaluated in patients who received an oral care intervention and control patients who did not receive the intervention. Methods: In this study, 22 stroke patients who were admitted to the ICU between June 2011 and August 2012 underwent oral examinations and were provided with an oral care intervention that included tooth brushing with an interdental brush and the use of a chlorhexidine mouthwash (oral care group), while 21 patients who were admitted to the ICU during the same period did not receive the oral care intervention but underwent oral examination and served as controls (non-oral care group). In the oral care group, oral care was performed once a day for 1-5 weeks according to the general health of the patient. The patients in the oral care group underwent oral examination before and after the oral care intervention. Plaque index, gingival index, clinical attachment loss (CAL), and presence of Candida were evaluated in both the groups. Results: The plaque index and gingival index of the oral care group were significantly lower than those of the non-oral care group; however, no significant difference in CAL was observed. The levels of Candida in the pra; care group were ;ower than those om the non-oral care group. However, no significant intergroup difference was observed in the levels of Candida. Conclusions: Oral care interventions improved oral health, including oral hygiene and periodontal health, of stroke patients in the ICU. Therefore, this study showed that oral care interventions can be effectively used to improve the oral health of stroke patients in the ICU.

Copyright © 2013 by Journal of Korean Academy of Oral Health This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives: The aim of this study was to examine the characteristics of the high caries risk group among 12-year-old children in Korea. Methods: Information on oral health status and interview data were collected from 6,253 children (3,309 male and 2,944 female children) aged 12 years who participated in the Korea National Oral Health Survey in 2010. The subjects were sorted according to the decayed missing filled tooth (DMFT) data. The highest one-third was selected as the significant caries (SiC) group (N=2,184), and the others were classified as the middle group (N=4,466) and the caries-free group (N=7,067). This study also used demographic variables such as gender and area of residence. The variables for the oral health behavior were the number of dental sealants on the first molar, self-perceived oral health, average frequency of tooth brushing per day, and the mean frequency of daily snack consumption. The variables for the oral health status were the mean number of DMFTs and the SiC index. The associations between the high caries risk group and the demographic and social variables, oral health status, and oral health-related consciousness and behavior were evaluated by logistic regression analysis. Results: A significant proportion of the high caries risk group participants had no dental sealant on the first molar (46.4%) and lived in rural areas (38.1%, P

This review provides an overview of the published data on the canola meal and its suitability for duck as an alternative plant-origin protein source to soybean meal. Canola meal is a legume origin protein source containing comparable amino acid profile to soybean meal and rich in essential minerals and vitamins. Nonetheless, it is known to contain less in energy content than soybean meal. Factors like field conditions and processing methods creates compositional variations among canola meal. Presence of anti-nutritional factors such as phenolic substances, phytate and glucosinolates which are known to reduce growth performance in livestock animals, are the major drawbacks for canola meal to be a competitive plant-origin protein source in the feed industry. This review is focused to address i) nutritional characteristics and feeding value of canola meal for ducks and ii) impacts of feeding canola meal on performances of ducks.