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The ability of the liver to recover from ischemia/reperfusion (I/R) injury depends on the integrity of the micro-circulation.1 It has been recently reported that endothelin (ET) plays a major role in the regulation of hepatic microcirculation.2 The aim of this study is to determine whether inhibition of the binding of endothelin to its receptors by a non-selective (ETA, ETB) receptor antagonist, TAK-0443 can lessen liver injury after 2 hours of warm ischemia.

A case of quadricuspid aortic valve with aortic regurgitation is reported. This cardiac malformation is very rare and usually diagnosed at aortic valve surgery or at autopsy. The case presented here was preoperatively diagnosed by echocardiography, and aortic valve replacement was performed successfully.