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51. Is the recovery from chest infection influenced by the type of antibiotic prescribed?

Author

Nasar, M. Abu

Subjects
*CHEST diseases, *THERAPEUTICS
Abstract

Identifies the effect of specific antibiotic therapy for rapid recovery with improved quality of life for elderlies with chest infection. Incidence of chest infection in the elderly; Assessment of elderly patients with clinical diagnosis of chest infection; Measurement of functional recovery; Factors determining the recovery of patients with chest infection.

Published
1994
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52. Unusual causes of severe orthostatic hypotension

Author

Nasar, M Abu and Murty, Shaku

Abstract

Two elderly female patients presented with severe refractory orthostatic hypotension, one of which was an isolated case and the other as a part of multisystem atrophy (MSA; Shy-Drager syndrome). Both patients showed significant improvement in blood pressure (BP) and postural symptoms following administration of midodrine, a peripherally acting a-adrenergic agonist.

Published
2002
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53. Rapid reaction to Parkinson's.

Author

Nasar, M. Abu

Abstract

A letter to the editor is presented in response to an article on living with Parkinson's disease, by Dileas Sweetenham, in the April 16 to 19, 2007 issue.

Published
2007

54. Multiplicity dependence of two-particle azimuthal correlations in pp collisions at the LHC

Author

G. Viesti, B. Fenton-Olsen, Shingo Sakai, Alessandro Grelli, Tomoya Tsuji, Guy Paic, Deepa Thomas, Joel Anthony Mazer, L. Cifarelli, B. H. Han, C. D. Anson, Stefan Thomas Heckel, Christian Holm Christensen, Myunggeun Song, Alina Gabriela Grigoras, Livio Bianchi, R. Cruz Albino, I. Garishvili, Federico Cindolo, L. Šándor, S. K. Basu, Eleazar Cuautle, Sun Kun Oh, Y. Hori, A. Szanto de Toledo, Alexandru Florin Dobrin, Y. W. Baek, D. Tlusty, Alexander Mamonov, Fengchu Zhou, Muhammad Ajaz, Jurgen Schukraft, M. Mohisin Khan, K. Das, I. Berceanu, Borge Svane Nielsen, T. Czopowicz, Luciano Musa, Roberto Divia, Bedangadas Mohanty, Dimitry Aleksandrov, S. Porteboeuf-Houssais, G. Cara Romeo, Yvonne Chiara Pachmayer, M. Spacek, Christoph Blume, Andrzej Rybicki, Christian Lippmann, Chiara Zampolli, Satyabrata Kar, Victor Trubnikov, Julien Faivre, Andrei Ionut Herghelegiu, Heiko Engel, D. R. Gangadharan, T. Pawlak, G. O.V. de Barros, Vit Kucera, Ciprian Mihai Mitu, C. Søgaard, P. L. M. Podesta-Lerma, Dario Berzano, F. Zhang, Peter Malzacher, B. Hicks, F. Padilla, Jiebin Luo, Federico Carminati, V. Wagner, Luke David Hanratty, E. G. Ferreiro, L. K. Mangotra, Ionel Stan, Ajay Kumar Dash, Levente Molnar, D. Emschermann, M. Pachr, A. C. Oliveira Da Silva, Nicola Bianchi, W. Rauch, A. Tarazona Martinez, Lee Stuart Barnby, F. Rettig, Cristina Terrevoli, Raimond Snellings, Cynthia Marie Hadjidakis, Adrian Sevcenco, E. Nappi, Rene Brun, Marco Marquard, Sona Pochybova, Theo Alexander Broker, Raphaelle Marie Bailhache, Anik Gupta, A. De Falco, Sanjib Muhuri, P. Roy, F. Blanco, V. Catanescu, Iosif Legrand, Indranil Das, V. Altini, Marc Weber, A. A. Rademakers, A. Fernández Téllez, Martin Poghosyan, R. Smakal, A. V. Kazantsev, F. Baltasar Dos Santos Pedrosa, Enrichetta Maria Fiore, Gian Michele Innocenti, Jogender Saini, Natalia Kondratyeva, Xavier Bernard Lopez, Jaroslav Bielcik, Marco Monteno, Elena Rogochaya, Mateusz Andrzej Ploskon, Siegfried Valentin Foertsch, Jaroslav Adam, C. Baumann, Csaba Soos, Peter Chochula, Christophe Pierre Suire, M. Wilde, D. Peresunko, Kirill Voloshin, Trine Spedstad Tveter, Ivan Kisel, Dmitry Blau, C. Roy, Giacomo Volpe, P. Vande Vyvre, Z. Conesa del Valle, L. Vannucci, HT Yang, A. Szczepankiewicz, Federico Ronchetti, Filippo Costa, Oliver Busch, V. Lenti, Sergey Gorbunov, Andre Mischke, A. Jacholkowski, B. Grinyov, Ulrich Fuchs, Corrado Gargiulo, Sara Vallero, Sudipan De, Natasha Sharma, Kamal Hussain Khan, Mikhail Ippolitov, M. Kim, P. I. Loenne, Ewa Gladysz-dziadus, Jan Rak, Vikas Singhal, Håvard Helstrup, Constantinos Loizides, R. T. Jimenez Bustamante, Antonio Uras, G. Conesa Balbastre, Peter Martin Jacobs, Jon Christopher Wikne, Stefania Bufalino, Jihyun Bhom, A. M. Gago, Y. J. Kwon, Giacomo Bruno, Michal Petran, Ramni Gupta, Ilaria Aimo, D. Hatzifotiadou, Predrag Buncic, Laszlo Boldizsar, J. Takahashi, Pradip Kumar Sahu, M. Krus, M. Spyropoulou-Stassinaki, Marcelo Gameiro Munhoz, Sidharth Kumar Prasad, Stefania Beole, I. Hřivnáčová, Marian Ivanov, Marco De Petris, Jens Wiechula, M. E. Cotallo, Jai Samuel Nielsen Salzwedel, Supriya Das, B. K. Srivastava, Mikhail Stolpovskiy, Andrew Ivanov, Sean Murray, Linus Feldkamp, Andres Sandoval, Ermanno Vercellin, I. S. Zgura, M. A. Mazzoni, Artem Konevskikh, Debojit Sarkar, B. Ghidini, J. F. Castillo Hernandez, Ionut Christian Arsene, B. Polichtchouk, Valeria Muccifora, Maria Vasileiou, Yu. V. Kharlov, Vladislav Manko, Anton Jusko, A. K. Dutta Majumdar, E. Fragiacomo, Anton Andronic, Meidana Huang, Ian Gardner Bearden, H. J. Jang, D. Wielanek, Ken Oyama, M. Kretz, Ivan Kralik, Miroslav Pikna, T. C. Awes, Rune Langøy, Roberta Arnaldi, Jean-Yves Grossiord, Kyoichiro Ozawa, G. Tejeda Muñoz, Paola Gianotti, Mario Sitta, Giacomo Contin, Oleg Karavichev, Vladimir Kaplin, Bogdan Vulpescu, L. Montaño Zetina, T. J. Humanic, Kai Oliver Schweda, V. Paticchio, Vladimir Kovalenko, Vito Manzari, L. Riccati, Leonid Vinogradov, Gabor Kiss, D. W. Kim, Shiming Yang, G. Stefanek, Vladimir Nikulin, Maria Haiduc, Rosario Nania, P. Kaliňák, S. Yasnopolskiy, M. Nasar, I. K. Yoo, Boris Hippolyte, G.S. Shabratova, Marek Kowalski, S. Sharma, Friederike Bock, Aditya Nath Mishra, Biswarup Paul, F. Scarlassara, Mikhail V. Kompaniets, Adela Kravcakova, C. Bianchin, Alexandre Shabetai, K. Šafařík, J. Anielski, M. A. Lisa, Barbara Ewa Erazmus, Maria Nicassio, Premomoy Ghosh, Konstantin Mikhaylov, Sami Sakari Rasanen, Michelangelo Agnello, Gyula Bencedi, M. Heide, Alexey Kuryakin, A. Rakotozafindrabe, M. Bombara, N. Herrmann, Tatsuya Chujo, Johanna Stachel, Tuva Ora Herenui Richert, Peter Glassel, R. N. Singaraju, E. Crescio, M. Bach, Francesco Barile, E. Pereira De Oliveira Filho, Graham Richard Lee, Jacek Tomasz Otwinowski, M. R. Cosentino, Austin Vincent Harton, Jan Wagner, A. De Caro, P. Di Nezza, Maitreyee Mukherjee, Xiang Zhang, Hans Muller, Alexander Kluge, C. Lara, Gennady Zinovjev, Sadhana Dash, Andrea Dubla, Ivan Vorobyev, R. Varma, Z. Vilakazi, Giuseppe Simonetti, Andrew Marshall Adare, J. Bartke, X. Sanchez Castro, Romualdo Santoro, H. León, Elisa Incani, Ralf Peter Averbeck, L. Goerlich, Petra Riedler, Federico Antinori, F. Soramel, Alexis Jean-Michel Mas, Mikhail Malaev, Radiy Ilkaev, Xiangrong Zhu, A. Karasu Uysal, Dieter Røhrich, Mihaela Gheata, Satoshi Yano, Gilda Scioli, M. Venaruzzo, Bongsoo Kim, B. S. Chang, G. Steyn, Paolo Pagano, B. V.K.S. Potukuchi, Iwona Anna Sputowska, R. Russo, Alessandro Ferretti, Markus Fasel, P. G. Innocenti, P. Zelnicek, Redmer Alexander Bertens, G. V. Margagliotti, Joakim Nystrand, Shao-Ping Li, V. Petráček, Ruben Shahoyan, D. Eschweiler, Pietro Cortese, Janka Vrlakova, K. Shtejer, C. Lagana Fernandes, Daniel Berenyi, N. Zaviyalov, Evgeny Karpechev, G. Aglieri Rinella, Boris Batyunya, D. Budnikov, Ankita Goswami, You Zhou, F.F. Guber, Zubayer Ahammed, C. Garabatos, Paolo Martinengo, Rudiger Haake, Krzysztof Redlich, A. Casanova Díaz, Gerardus Nooren, Jan Musinsky, Ombretta Pinazza, Rui Ma, Christoph Mayer, Yu.N. Pestov, V. R. Loggins, A. Palaha, I. E. Yushmanov, Thanushan Kugathasan, Eugen Mudnic, M. Lechman, Ara Grigoryan, Jorn Henning Putschke, Mais Kazim Oglu Suleymanov, Laurent Ducroux, Juha Äystö, D. A. Moreira De Godoy, Cenek Zach, Johan Alme, Luciano Ramello, Panagiotis Christakoglou, G. Koyithatta Meethaleveedu, Claudiu Cornel Schiaua, V. Razazi, Shih-Chang Lee, Philipp Johannes Luettig, Madan M. Aggarwal, Benjamin Andreas Hess, Alexandru Bercuci, Anthony Robert Timmins, Cristiane Jahnke, J. L. Klay, A. R. Reolon, C. Oppedisano, Adam Ryszard Kisiel, D. Vranic, Vitaly Loginov, Sandra Moretto, Andrea Danu, P. Ladron de Guevara, Guillaume Batigne, Martijn Reicher, J. Castillo Castellanos, Y. Sibiriak, Kenneth Francis Read, Jan Cepila, Attiq Ur Rehman, Motoi Inaba, M. Sano, Alexander Philipp Kalweit, J. Pluta, Evgeny Ryabinkin, Thorsten Sven Kollegger, Teodor Siemiarczuk, Kyrre Skjerdal, Y. Wang, Sergey Filchagin, Olja Dordic, Catherine Micaela Silvestre, Alberica Toia, H. Zhang, Magnus Mager, W. J. Park, Pietro Antonioli, S.A. Sadovsky, Jitendra Kumar, T. P. Sinha, Davide Francesco Lodato, Hanna Paulina Zbroszczyk, H. A. Torii, Stefan Rossegger, I. Lakomov, C. E. Pérez Lara, Alexander Borissov, Costin Grigoras, Alexei Khanzadeev, Domenico Colella, Martin Andreas Volkl, Vladimir Samsonov, H. Bøggild, G. M. Urciuoli, Christian Claude Kuhn, H. Appelshäuser, M. Zynovyev, Christine Nattrass, Jussi Samuli Viinikainen, D. Truesdale, Dmitry Finogeev, Podist Kurashvili, Y. P. Viyogi, Subhash Singha, Ketil Røed, P. Cerello, D. Watanabe, Bikash Sinha, N. Grion, Andrea Agostinelli, E. Montes, Tome Anticic, Marta Verweij, Toru Sugitate, Michele Floris, Andrea Alici, W. Peryt, D. M. Madagodahettige-Don, Serhiy Senyukov, Dai-Mei Zhou, Sergey Nikolaev, Carlos A. Salgado, Christophe Furget, Ijaz Ahmed, Jean Willy Andre Cleymans, Volker Lindenstruth, A. G. Asryan, F. Prino, M. Gallio, Sabyasachi Siddhanta, Jacobus Onderwaater, I. Martashvili, Renu Bala, David Michael Rohr, E. Stenlund, Wisla Carena, Martino Gagliardi, J. Lehnert, Michal Sumbera, C. G. Yaldo, Rene Bellwied, T. J. M. Symons, Annika Passfeld, Florian Painke, A. B. Kaidalov, Sang Un Ahn, Eugenio Scapparone, Lukasz Kamil Graczykowski, G. Simatovic, J. Mercado Pérez, P. La Rocca, Alberto Caliva, Antonin Maire, Yves Roland Schutz, E. Calvo Villar, Edmundo Javier Garcia-Solis, Bastian Bathen, M. Basile, Henrik Qvigstad, M. Boccioli, Alexey Kurepin, Gyulnara Eyyubova, Dosatsu Sakata, M. C.S. Williams, Alberto Masoni, Benjamin Donigus, J. de Cuveland, N. Pitz, Valentina Zaccolo, J. Mlynarz, Stefan Kirsch, Felix Reidt, Sergey Nikulin, D. Di Bari, D. De Gruttola, T. Kalliokoski, A. Rodriguez Manso, V. Chibante Barroso, Hans Rudolf Schmidt, J. Zhu, Valery Punin, S.A. Zaporozhets, Adriana Telesca, Andrey Reshetin, Jochen Gerhard, Basanta Kumar Nandi, Svein Lindal, Fiorella Fionda, Fabio Filippo Colamaria, A. Di Mauro, Franco Meddi, B. Ketzer, Cristian Andrei, Venelin Anguelov, Nazeer Ahmad, Franck Manso, X. G. Lu, Sukalyan Chattopadhyay, Marcello Lunardon, Hege Austrheim Erdal, Rama Chandra Baral, Annalisa Mastroserio, Jan Fiete Grosse-Oetringhaus, Igor Altsybeev, Andrei Gheata, Seyong Kim, Mihai Petrovici, Henning Kværnø, D. Elia, Bernd Stefan Windelband, Helmut Oskar Oeschler, Jihye Song, Rishat Sultanov, S. Esumi, M. Irfan, Martin Vala, Ping Yang, Cvetan Valeriev Cheshkov, Antonio Rossi, Peter Braun-Munzinger, Thomas Peitzmann, J. S. Kim, J. Thäder, Raghunath Sahoo, Valerie Ramillien Barret, V. Nikolic, Ilya Selyuzhenkov, S. U. Chung, M. A. Diaz Corchero, C. Ionita, A. J. Rubio Montero, Sven Gotovac, Néstor Armesto, Kristin Fanebust Hetland, Svetlana Kushpil, Sanjeev Singh Sambyal, Dirk Hutter, M. Rodríguez Cahuantzi, M. Lenhardt, J. S. Real, C. Pajares, Y. L. Yamaguchi, Hans Peter Beck, R. de Rooij, Mohd Danish Azmi, Dong Jo Kim, Laszlo Olah, Udo Wolfgang Kebschull, Pascal Dupieux, Andrea Dainese, Sergey Fokin, Arturo Tauro, S. De Pasquale, J. Ulery, L. Toscano, D. Perrino, S. A. Ahn, I. León Monzón, Øystein Djuvsland, Iouri Belikov, Thomas Dietel, Arturo Alejandro Menchaca-Rocha, B. von Haller, C. Xiang, Igor Pshenichnov, C. Cicalo, Philippe Rosnet, A. W. Rauf, E. A. R. Casula, Nirbhay Kumar Behera, K. Ma, M. Cherney, I. Cortés Maldonado, Amalia Pop, Rosi Reed, Thomas Michael Cormier, Leonardo Milano, J. Bán, Rachid Guernane, Roman Lietava, I. Kulakov, Øystein Senneset Haaland, Imrich Szarka, Alex Hansen, Michal Meres, Tiziano Virgili, P. Petrov, Torsten Alt, Nicole Bastid, Daniel Lohner, Marco Leoncino, Jan Figiel, Peter Strmen, A. Ahmad Masoodi, Jovan Milosevic, C. Cavicchioli, Frederick Kramer, Alice Zimmermann, Vladimir Vechernin, Peter Levai, Eva Sicking, N. Carlin Filho, R. Gomez, M. Estienne, K. K. Loo, Anders Garritt Knospe, Gergely Gabor Barnafoldi, Y. Martynov, Nicolas Arbor, R. Mazumder, Alberto Baldisseri, Latchezar Betev, J. J. Gaardhøje, Alexey Bogdanov, Kristjan Herlache Gulbrandsen, Johannes Peter Wessels, Hongbo Zhu, Y. Berdanikov, Marco Bregant, Dominik Fehlker, J. P. Revol, A. Hayrapetyan, M. Steinpreis, Henner Buesching, Min Jung Kweon, S. L. La Pointe, David H. Evans, A. Ochirov, R. Romita, Diego Stocco, P. A. Scott, J. W. Harris, D. M. Jha, Jeremy John Wilkinson, Agneta Oskarsson, A. Rachevski, A. Matyja, Janusz Oleniacz, Ana Vargas, Danthasinghe Piyarathna, I. Maldonado Cervantes, Elena Bruna, Silvia Masciocchi, Klaus Johannes Reygers, Astrid Morreale, Petr Zavada, Kenta Shigaki, A. Tarantola Peloni, Michael Linus Knichel, Deepika Rathee, Renaud Vernet, C. Klein-Bösing, Massimiliano Marchisone, A. S. Nyanin, F. Bellini, Paulus Gerardus Kuijer, Kilian Eberhard Schwarz, R. P. Scharenberg, Christina Markert, R. Keidel, Paul Christoph Bätzing, J. Martin Blanco, Stefano Piano, A. Zichichi, A. Nyatha, Vardanush Papikyan, R. Scott, Dagmar Adamová, Ante Bilandzic, Marian Krivda, Grzegorz Andrzej Wilk, Matthias Richter, G. Herrera Corral, Lawrence Pinsky, Jochen Klein, Sergey Kiselev, Andreas Morsch, A. Palmeri, Uwe Westerhoff, A. Pesci, S. Kox, G. Hamar, J. H. Kim, Yasuo Miake, Palash Khan, Davide Caffarri, A. Ortiz Velasquez, Johannes Hendrik Stiller, Airton Deppman, Alla Maevskaya, M. I. Martínez, Michal Krelina, Mirko Planinic, C.J. Schmidt, S. Schuchmann, Vladimir Ivanov, Didier Alexandre, G. L. Usai, A. Arend, Sylvain Chapeland, Rinaldo Rui, H. Pereira Da Costa, M. Fusco Girard, G. D Erasmo, Sergey Evdokimov, Cinzia Luzzi, Jiri Kral, Boris Wagner, Tyler Allen Browning, J. G. Contreras, Shinichi Hayashi, Paolo Giubellino, Philippe Crochet, L. Manceau, E. López Torres, A. Kolojvari, Andrey Zarochentsev, E. Cruz Alaniz, Bogdan Theodor Rascanu, M. Masera, S. Serci, Alexandre Alarcon Do Passo Suaide, D. P. Mahapatra, Rosario Turrisi, Jørgen André Lien, M. Morando, Bruno Espagnon, Antoine Xavier Lardeux, A. A. Vinogradov, V. Kushpil, Liudmila Malinina, V. Grigoriev, Y. Corrales Morales, S. Di Liberto, Toralf Bernhard Skaali, Ramona Lea, Jörg Bornschein, Laurent Bernard Aphecetche, G. Martínez García, Herve Borel, H. Sakaguchi, P. González-Zamora, Bruno Alessandro, M. A. Subieta Vásquez, Silvia Arcelli, P. H. S. Y. Jayarathna, H. Caines, Sudhir Raniwala, A. G. Agocs, Dariusz Czeslaw Miskowiec, Tatiana Karavicheva, Subikash Choudhury, Alberto Collu, Paolo Camerini, Sergey Voloshin, R. A. Soltz, E. Floratos, M. E. Connors, Linda Vickovic, D. Fabris, Yonghong Zhang, David Dobrigkeit Chinellato, Raphaelle Ichou, Z. Yin, David Olle Rickard Silvermyr, Barbara Guerzoni, A. Vyushin, Peter Zahariev Hristov, Peter Christiansen, N. Poljak, G. Puddu, M. Vajzer, G. S. Pappalardo, R. Dang, Wladyslaw Henryk Trzaska, Angelo Rivetti, J.A. Mares, Grazia Luparello, Mads Stormo Nilsson, Paraskevi Ganoti, Satyajit Jena, Maxime Guilbaud, M. van Leeuwen, S. K. Pal, J. L. Charvet, Dmitry Mal'kevich, Rainer Arno Ernst Renfordt, A. Nedosekin, Petr Nomokonov, Martin Schulc, Juyeon Yi, E. Braidot, Alexander Akindinov, O. Villalobos Baillie, Rashmi Raniwala, J. W. Van Hoorne, R. A. Ricci, K. Polák, V. P. Kondratiev, F. Bossú, T. Breitner, Claude Andre Pruneau, Roberto Barbera, P. Gros, Elena Botta, Andrey Vasiliev, R. Grajcarek, Enrico Scomparin, Michael Andreas Winn, Rajeev Singh, Andrea Francescon, Ana Maria Marin, Oleksii Ivanytskyi, Francesco Noferini, E. Dénes, V. Canoa Roman, A. K. Bhati, A. I. Pavlinov, J. H. Kang, X. Cai, T. Aronsson, Davide Falchieri, Nikolai Smirnov, Michal Broz, Nicole Alice Martin, Raphael Noel Tieulent, Sedat Altinpinar, T. K. Nayak, H.R. Gulkanyan, Marcel Araujo Silva Figueredo, Anju Bhasin, F. Carena, Taku Gunji, G. A. Feofilov, M. Zhalov, Maciej Pawel Szymanski, Philippe Pillot, L. Cunqueiro, Mikolaj Krzewicki, M. Botje, G. Santagati, Raffaele Grosso, Anton Alkin, S. Böttger, V. Pospíšil, A. A.E. Bergognon, Shuaib Ahmad Khan, A. B. Kurepin, Jongik Yoon, H. Delagrange, T. Dobrowolski, Mihai Niculescu, Michael Wang, D. S. Hwang, A. Feliciello, Patrick Simon Reichelt, B. S. Nilsen, T.A. Pocheptsov, Sergey Nazarenko, Sandro Bjelogrlic, Betty Abelev, Jeewon Seo, Saehanseul Oh, C. Di Giglio, Filip Krizek, Branislav Sitar, Catia Petta, Kjetil Ullaland, N. De Marco, E. Belmont-Moreno, Brigitte Cheynis, Hannes Jung, T. Moon, Francesco Riggi, Panagiota Foka, T. Susa, Mesut Arslandok, Werner Riegler, T.H. Kim, Hideki Hamagaki, Gunnar Løvhøiden, Anselmo Margotti, G.F. Segato, D. I. Patalakha, G. de Cataldo, M. Veldhoen, Alessandra Fantoni, Angela Badala, P. Ostrowski, K. Watanabe, S. Rohni, A. Ter Minasyan, Anand Kumar Dubey, Hans Martin Ljunggren, Y. Kucheriaev, J. D. Tapia Takaki, Sergio Vergara, Tim Schuster, C. Ceballos Sanchez, Y. Zoccarato, C. Nygaard, Debasish Das, Evgeny Kryshen, Laure Marie Massacrier, Malgorzata Anna Janik, Y. Vinogradov, L. Valencia Palomo, B. G. Elwood, M. A. Tangaro, Roberto Preghenella, Marek Chojnacki, I. Ilkiv, E. Serradilla, M. Bogolyubsky, Marie Germain, Ulrich Michael Frankenfeld, Maksym Zyzak, Alexander Vodopyanov, Alexandr Tumkin, J. Ulrich, Markus Konrad Kohler, M. Kliemant, Z. Buthelezi, Roy Crawford Lemmon, Andrea Festanti, Jana Bielcikova, Sebastian Kalcher, Bjarte Kileng, Peter Graham Jones, Smbat Grigoryan, Rainer Martin Schicker, Andrzej Deloff, D. Felea, J. Book, Andre Augustinus, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), ALICE, Universidade Estadual de Campinas, B. Abelev, J. Adam, D. Adamová, A.M. Adare, M.M. Aggarwal, G. Aglieri Rinella, M. Agnello, A.G. Agoc, A. Agostinelli, Z. Ahammed, A. Ahmad Masoodi, N. Ahmad, I. Ahmed, S.U. Ahn, S.A. Ahn, I. Aimo, M. Ajaz, A. Akindinov, D. Aleksandrov, B. Alessandro, D. Alexandre, A. Alici, A. Alkin, J. Alme, T. Alt, V. Altini, S. Altinpinar, I. Altsybeev, C. Andrei, A. Andronic, V. Anguelov, J. Anielski, C. Anson, T. Antičić, F. Antinori, P. Antonioli, L. Aphecetche, H. Appelshäuser, N. Arbor, S. Arcelli, A. Arend, N. Armesto, R. Arnaldi, T. Aronsson, I.C. Arsene, M. Arslandok, A. Asryan, A. Augustinu, R. Averbeck, T.C. Awe, J. Äystö, M.D. Azmi, M. Bach, A. Badalà, Y.W. Baek, R. Bailhache, R. Bala, A. Baldisseri, F. Baltasar Dos Santos Pedrosa, J. Bán, R.C. Baral, R. Barbera, F. Barile, G.G. Barnaföldi, L.S. Barnby, V. Barret, J. Bartke, M. Basile, N. Bastid, S. Basu, B. Bathen, G. Batigne, B. Batyunya, P.C. Batzing, C. Baumann, I.G. Bearden, H. Beck, N.K. Behera, I. Belikov, F. Bellini, R. Bellwied, E. Belmont-Moreno, G. Bencedi, S. Beole, I. Berceanu, A. Bercuci, Y. Berdanikov, D. Berenyi, A.A.E. Bergognon, R.A. Berten, D. Berzano, L. Betev, A. Bhasin, A.K. Bhati, J. Bhom, L. Bianchi, N. Bianchi, C. Bianchin, J. Bielčík, J. Bielčíková, A. Bilandzic, S. Bjelogrlic, F. Blanco, D. Blau, C. Blume, M. Boccioli, F. Bock, S. Böttger, A. Bogdanov, H. Bøggild, M. Bogolyubsky, L. Boldizsár, M. Bombara, J. Book, H. Borel, A. Borissov, J. Bornschein, F. Bossú, M. Botje, E. Botta, E. Braidot, P. Braun-Munzinger, M. Bregant, T. Breitner, T.A. Broker, T.A. Browning, M. Broz, R. Brun, E. Bruna, G.E. Bruno, D. Budnikov, H. Buesching, S. Bufalino, P. Buncic, O. Busch, Z. Buthelezi, D. Caffarri, X. Cai, H. Caine, A. Caliva, E. Calvo Villar, P. Camerini, V. Canoa Roman, G. Cara Romeo, F. Carena, W. Carena, N. Carlin Filho, F. Carminati, A. Casanova Díaz, J. Castillo Castellano, J.F. Castillo Hernandez, E.A.R. Casula, V. Catanescu, C. Cavicchioli, C. Ceballos Sanchez, J. Cepila, P. Cerello, B. 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R., Loginov, V., Lohner, D., Loizides, C., Loo, K. K., Lopez, X., López Torres, E., Løvhøiden, G., X. G., Lu, Luettig, P., Lunardon, M., Luo, J., Luparello, G., Luzzi, C., Ma, R., Ma, K., Madagodahettige Don, D. M., Maevskaya, A., Mager, M., Mahapatra, D. P., Maire, A., Malaev, M., Maldonado Cervantes, I., Malinina, L., Mal’Kevich, D., Malzacher, P., Mamonov, A., Manceau, L., Mangotra, L., Manko, V., Manso, F., Manzari, V., Marchisone, M., Mareš, J., Margagliotti, Giacomo, Margotti, A., Marín, A., Markert, C., Marquard, M., Martashvili, I., Martin, N. A., Martin Blanco, J., Martinengo, P., Martínez, M. I., Martınez García, G., Martynov, Y., Mas, A., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Mastroserio, A., Matyja, A., Mayer, C., Mazer, J., Mazumder, R., Mazzoni, M. A., Meddi, F., Menchaca Rocha, A., Mercado Pérez, J., Meres, M., Miake, Y., Mikhaylov, K., Milano, L., Milosevic, J., Mischke, A., Mishra, A. N., Miskowiec, D., Mitu, C., Mlynarz, J., Mohanty, B., Molnar, L., Montaño Zetina, L., Monteno, M., Montes, E., Moon, T., Morando, M., Moreira De Godoy, D. A., Moretto, S., Morreale, A., Morsch, A., Muccifora, V., Mudnic, E., Muhuri, S., Mukherjee, M., Müller, H., Munhoz, M. G., Murray, S., Musa, L., Musinsky, J., Nandi, B. K., Nania, R., Nappi, E., Nasar, M., Nattrass, C., Nayak, T. K., Nazarenko, S., Nedosekin, A., Nicassio, M., Niculescu, M., Nielsen, B. S., Nikolaev, S., Nikolic, V., Nikulin, S., Nikulin, V., Nilsen, B. S., Nilsson, M. S., Noferini, F., Nomokonov, P., Nooren, G., Nyanin, A., Nyatha, A., Nygaard, C., Nystrand, J., Ochirov, A., Oeschler, H., Oh, S., S. K., Oh, Olah, L., Oleniacz, J., Oliveira Silva, A. C., Onderwaater, J., Oppedisano, C., Ortiz Velasquez, A., Oskarsson, A., Ostrowski, P., Otwinowski, J., Oyama, K., Ozawa, K., Pachmayer, Y., Pachr, M., Padilla, F., Pagano, P., Paić, G., Painke, F., Pajares, C., Pal, S. K., Palaha, A., Palmeri, A., Papikyan, V., Pappalardo, G. S., Park, W. J., Passfeld, A., Patalakha, D. I., Paticchio, V., Paul, B., Pavlinov, A., Pawlak, T., Peitzmann, T., Pereira Da Costa, H., Pereira De Oliveira Filho, E., Peresunko, D., Pérez Lara, C. E., Perrino, D., Peryt, W., Pesci, A., Pestov, Y., Petráček, V., Petran, M., Petris, M., Petrov, P., Petrovici, M., Petta, C., Piano, Stefano, Pikna, M., Pillot, P., Pinazza, O., Pinsky, L., Pitz, N., Piyarathna, D. B., Planinic, M., Ploskon, M., Pluta, J., Pocheptsov, T., Pochybova, S., Podesta Lerma, P. L. M., Poghosyan, M. G., Polák, K., Polichtchouk, B., Poljak, N., Pop, A., Porteboeuf Houssais, S., Pospíšil, V., Potukuchi, B., Prasad, S. K., Preghenella, R., Prino, F., Pruneau, C. A., Pshenichnov, I., Puddu, G., Punin, V., Putschke, J., Qvigstad, H., Rachevski, A., Rademakers, A., Rak, J., Rakotozafindrabe, A., Ramello, L., Raniwala, R., Raniwala, S., Räsänen, S. S., Rascanu, B. T., Rathee, D., Rauch, W., Rauf, A. W., Razazi, V., Read, K. F., Real, J. S., Redlich, K., Reed, R. J., Rehman, A., Reichelt, P., Reicher, M., Reidt, F., Renfordt, R., Reolon, A. R., Reshetin, A., Rettig, F., Revol, J. P., Reygers, K., Riccati, L., Ricci, R. A., Richert, T., Richter, M., Riedler, P., Riegler, W., Riggi, F., Rivetti, A., Rodríguez Cahuantzi, M., Rodriguez Manso, A., Røed, K., Rogochaya, E., Rohr, D., Röhrich, D., Romita, R., Ronchetti, F., Rosnet, P., Rossegger, S., Rossi, A., Roy, C., Roy, P., Rubio Montero, A. J., Rui, Rinaldo, Russo, R., Ryabinkin, E., Rybicki, A., Sadovsky, S., Šafařík, K., Sahoo, R., Sahu, P. K., Saini, J., Sakaguchi, H., Sakai, S., Sakata, D., Salgado, C. A., Salzwedel, J., Sambyal, S., Samsonov, V., Sanchez Castro, X., Šándor, L., Sandoval, A., Sano, M., Santagati, G., Santoro, R., Sarkar, D., Scapparone, E., Scarlassara, F., Scharenberg, R. P., Schiaua, C., Schicker, R., Schmidt, C., Schmidt, H. R., Schuchmann, S., Schukraft, J., Schulc, M., Schuster, T., Schutz, Y., Schwarz, K., Schweda, K., Scioli, G., Scomparin, E., Scott, P. A., Scott, R., Segato, G., Selyuzhenkov, I., Senyukov, S., Seo, J., Serci, S., Serradilla, E., Sevcenco, A., Shabetai, A., Shabratova, G., Shahoyan, R., Sharma, S., Sharma, N., Rohni, S., Shigaki, K., Shtejer, K., Sibiriak, Y., Sicking, E., Siddhanta, S., Siemiarczuk, T., Silvermyr, D., Silvestre, C., Simatovic, G., Simonetti, G., Singaraju, R., Sputowska, I., Spyropoulou Stassinaki, M., Srivastava, B. K., Stachel, J., Stan, I., Stefanek, G., Steinpreis, M., Stenlund, E., Steyn, G., Stiller, J. H., Stocco, D., Stolpovskiy, M., Strmen, P., Suaide, A. A. P., Subieta Vásquez, M. A., Sugitate, T., Suire, C., Suleymanov, M., Sultanov, R., Šumbera, M., Susa, T., Symons, T. J. M., Singh, R., Singha, S., Singhal, V., Sinha, B. C., Sinha, T., Sitar, B., Sitta, M., Skaali, T. B., Skjerdal, K., Smakal, R., Smirnov, N., Snellings, R. J. M., Søgaard, C., Soltz, R., Song, M., Song, J., Soos, C., Soramel, F., Spacek, M., Szanto de Toledo, A., Szarka, I., Szczepankiewicz, A., Szymanski, M., Takahashi, J., Tangaro, M. A., Tapia Takaki, J. D., Tarantola Peloni, A., Tarazona Martinez, A., Tauro, A., Tejeda Muñoz, G., Telesca, A., Ter Minasyan, A., Terrevoli, C., Thäder, J., Thomas, D., Tieulent, R., Timmins, A. R., Tlusty, D., Toia, A., Torii, H., Toscano, L., Trubnikov, V., Truesdale, D., Trzaska, W. H., Tsuji, T., Tumkin, A., Turrisi, R., Tveter, T. S., Ulery, J., Ullaland, K., Ulrich, J., Uras, A., Urciuoli, G. M., Usai, G. L., Vajzer, M., Vala, M., Valencia Palomo, L., Vallero, S., Vande Vyvre, P., Hoorne, J. W., Leeuwen, M., Vannucci, L., Vargas, A., Varma, R., Vasileiou, M., Vasiliev, A., Vechernin, V., Veldhoen, M., Venaruzzo, Massimo, Vercellin, E., Vergara, S., Vernet, R., Verweij, M., Vickovic, L., Viesti, G., Viinikainen, J., Vilakazi, Z., Villalobos Baillie, O., Vinogradov, Y., Vinogradov, L., Vinogradov, A., Virgili, T., Viyogi, Y. P., Vodopyanov, A., Völkl, M. A., Voloshin, S., Voloshin, K., Volpe, G., Haller, B., Vorobyev, I., Vranic, D., Vrláková, J., Vulpescu, B., Vyushin, A., Wagner, V., Wagner, B., Wagner, J., Wang, M., Wang, Y., Watanabe, K., Watanabe, D., Weber, M., Wessels, J. P., Westerhoff, U., Wiechula, J., Wielanek, D., Wikne, J., Wilde, M., Wilk, G., Wilkinson, J., Williams, M. C. S., Windelband, B., Winn, M., Xiang, C., Yaldo, C. G., Yamaguchi, Y., Yang, H., Yang, S., Yang, P., Yano, S., Yasnopolskiy, S., Yi, J., Yin, Z., Yoo, I. K., Yoon, J., Yushmanov, I., Zaccolo, V., Zach, C., Zampolli, C., Zaporozhets, S., Zarochentsev, A., Závada, P., Zaviyalov, N., Zbroszczyk, H., Zelnicek, P., Zgura, I. S., Zhalov, M., Zhang, H., Zhang, X., Zhang, F., Zhang, Y., Zhou, D., Zhou, F., Zhou, Y., Zhu, H., Zhu, X., Zhu, J., Zichichi, A., Zimmermann, A., Zinovjev, G., Zoccarato, Y., Zynovyev, M., Zyzak, M., Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Kjerne- og elementærpartikkelfysikk: 431 [VDP], p p collisions, Monte Carlo method, MULTIPLICITY DEPENDENCE, azimuthal correlations, Parton, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Nuclear Experiment (nucl-ex), Nuclear Experiment, hadron-hadron scattering, Physics, Large Hadron Collider, Detector, Charged particle, Mathematics and natural scienses: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], Azimuth, PRIRODNE ZNANOSTI. Fizika, Transverse plane, Nuclear and elementary particle physics: 431 [VDP], Distributions, Particle Physics - Experiment, Nuclear and High Energy Physics, Particle physics, VDP::Matematikk og naturvitenskap: 400::Fysikk: 430::Kjerne- og elementærpartikkelfysikk: 431, FOS: Physical sciences, Hadron-Hadron Scattering, HADRON-COLLISIONS, DISTRIBUTIONS, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear physics, 0103 physical sciences, Azimuthal dihadron correlation, Nuclear Physics - Experiment, Multiplicity (chemistry), 010306 general physics, Hadron-Collisions, VDP::Mathematics and natural scienses: 400::Physics: 430::Nuclear and elementary particle physics: 431, ta114, 010308 nuclear & particles physics, Matematikk og naturvitenskap: 400::Fysikk: 430::Kjerne- og elementærpartikkelfysikk: 431 [VDP], ALICE experiment, NATURAL SCIENCES. Physics, High Energy Physics::Experiment
Abstract

We present the measurements of particle pair yields per trigger particle obtained from di-hadron azimuthal correlations in pp collisions at $\sqrt{s} = 0.9$, $2.76$, and $7$ TeV recorded with the ALICE detector. The yields are studied as a function of the charged particle multiplicity. Taken together with the single particle yields the pair yields provide information about parton fragmentation at low transverse momenta, as well as on the contribution of multiple parton interactions to particle production. Data are compared to calculations using the PYTHIA6, PYTHIA8, and PHOJET event generators., Comment: 36 pages, 18 captioned figures, 4 tables, authors from page 31, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/852

Published
2013
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56. Optimal extreme learning machine for diagnosing brain tumor based on modified sailfish optimizer.

Author

Ali Amin S, Alqudah MKS, Ateeq Almutairi S, Almajed R, Rustom Al Nasar M, and Ali Alkhazaleh H

Abstract

This study proposes a hierarchical automated methodology for detecting brain tumors in Magnetic Resonance Imaging (MRI), focusing on preprocessing images to improve quality and eliminate artifacts or noise. A modified Extreme Learning Machine is then used to diagnose brain tumors that are integrated with the Modified Sailfish optimizer to enhance its performance. The Modified Sailfish optimizer is a metaheuristic algorithm known for efficiently navigating optimization landscapes and enhancing convergence speed. Experiments were conducted using the "Whole Brain Atlas (WBA)" database, which contains annotated MRI images. The results showed superior efficiency in accurately detecting brain tumors from MRI images, demonstrating the potential of the method in enhancing accuracy and efficiency. The proposed method utilizes hierarchical methodology, preprocessing techniques, and optimization of the Extreme Learning Machine with the Modified Sailfish optimizer to improve accuracy rates and decrease the time needed for brain tumor diagnosis. The proposed method outperformed other methods in terms of accuracy, recall, specificity, precision, and F1 score in medical imaging diagnosis. It achieved the highest accuracy at 93.95 %, with End/End and CNN attaining high values of 89.24 % and 93.17 %, respectively. The method also achieved a perfect score of 100 % in recall, 91.38 % in specificity, and 75.64 % in F1 score. However, it is crucial to consider factors like computational complexity, dataset characteristics, and generalizability before evaluating the effectiveness of the method in medical imaging diagnosis. This approach has the potential to make substantial contributions to medical imaging and aid healthcare professionals in making prompt and precise treatment decisions for brain tumors., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 Published by Elsevier Ltd.)

Published
2024
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57. Diagnostic Yield of Critical Sample and Elective Fast-Test in Children After a Hypoglycemic Event: Experience From a Single Center in Israel.

Author

Carmon L, Hazan R, Hershkovitz E, David O, Shaki D, Walker D, Loewenthal N, Nasar M, Hazan G, and Haim A

Subjects
Child, Humans, Retrospective Studies, Israel, Fasting, Blood Glucose, Hypoglycemic Agents, Hypoglycemia diagnosis
Abstract

Objective: To determine the diagnostic yield of the critical sample and fast-tests as dynamic function tests for the work-up of hypoglycemia in children., Methods: A retrospective record review of children (0-18 years) with a diagnosis of hypoglycemia (glucose ≤ 50 mg/dL) was performed. A comparison of results of critical sample (obtained during an episode of hypoglycemia) and fast-test (performed to induce hypoglycemia in fasting state) was done., Results: In 317 patients with hypoglycemia, data of 89 critical samples and 52 fast-tests were taken. Only 7 (7.8%) patients who underwent critical sample testing received an endocrine or metabolic diagnosis. No confirmatory diagnoses were made using the fast-tests. Idiopathic ketotic hypoglycemia was detected in 33/89 (37.1%) of critical samples and 21/52 (40.4%) of fast-tests. The completeness of workup including the hormonal and metabolic profile was <80% in both tests., Conclusion: The confirmatory yield of critical sample was better than fast-test. The processing of metabolic analytes was incomplete in a few, suggesting the need to rationalize the dynamic function testing.

Published
2024

58. Whole-Genome Sequence of Multidrug-Resistant Escherichia coli Strains Isolated from Mice with Mastitis.

Author

Hoque MN, Jerin S, Faisal GM, Das ZC, Islam T, and Rahman ANMA

Abstract

We sequenced the genomes of Escherichia coli isolates G2M6U and G6M1F, two multidrug-resistant strains that were isolated from mammary tissue and fecal samples, respectively, from mice with induced mastitis. The complete genomes of G2M6U and G6M1F consist of chromosomes of 4.4 Mbp and 4.6 Mbp, respectively., Competing Interests: The authors declare no conflict of interest.

Published
2023
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59. Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study.

Author

Ehrlich A, Ioannidis K, Nasar M, Abu Alkian I, Daskal Y, Atari N, Kliker L, Rainy N, Hofree M, Shafran Tikva S, Houri I, Cicero A, Pavanello C, Sirtori CR, Cohen JB, Chirinos JA, Deutsch L, Cohen M, Gottlieb A, Bar-Chaim A, Shibolet O, Mandelboim M, Maayan SL, and Nahmias Y

Subjects
Humans, Lipids, PPAR alpha, Prospective Studies, SARS-CoV-2, Treatment Outcome, COVID-19, Fenofibrate therapeutic use
Abstract

Background: Viral infection is associated with a significant rewire of the host metabolic pathways, presenting attractive metabolic targets for intervention., Methods: We chart the metabolic response of lung epithelial cells to SARS-CoV-2 infection in primary cultures and COVID-19 patient samples and perform in vitro metabolism-focused drug screen on primary lung epithelial cells infected with different strains of the virus. We perform observational analysis of Israeli patients hospitalized due to COVID-19 and comparative epidemiological analysis from cohorts in Italy and the Veteran's Health Administration in the United States. In addition, we perform a prospective non-randomized interventional open-label study in which 15 patients hospitalized with severe COVID-19 were given 145 mg/day of nanocrystallized fenofibrate added to the standard of care., Results: SARS-CoV-2 infection produced transcriptional changes associated with increased glycolysis and lipid accumulation. Metabolism-focused drug screen showed that fenofibrate reversed lipid accumulation and blocked SARS-CoV-2 replication through a PPARα-dependent mechanism in both alpha and delta variants. Analysis of 3233 Israeli patients hospitalized due to COVID-19 supported in vitro findings. Patients taking fibrates showed significantly lower markers of immunoinflammation and faster recovery. Additional corroboration was received by comparative epidemiological analysis from cohorts in Europe and the United States. A subsequent prospective non-randomized interventional open-label study was carried out on 15 patients hospitalized with severe COVID-19. The patients were treated with 145 mg/day of nanocrystallized fenofibrate in addition to standard-of-care. Patients receiving fenofibrate demonstrated a rapid reduction in inflammation and a significantly faster recovery compared to patients admitted during the same period., Conclusions: Taken together, our data suggest that pharmacological modulation of PPARα should be strongly considered as a potential therapeutic approach for SARS-CoV-2 infection and emphasizes the need to complete the study of fenofibrate in large randomized controlled clinical trials., Funding: Funding was provided by European Research Council Consolidator Grants OCLD (project no. 681870) and generous gifts from the Nikoh Foundation and the Sam and Rina Frankel Foundation (YN). The interventional study was supported by Abbott (project FENOC0003)., Clinical Trial Number: NCT04661930., Competing Interests: AE is registered as an investor in a PCT regarding the use of metabolic regulators for COVID. The author has a patent on the use of PPAR agonists to treat COVID. The author has no other competing interests to declare, KI, MN, IA, YD, NA, LK, NR, MH, SS, IH, CP, MC, AG, AB, MM, SM No competing interests declared, AC has received personal honoraria for statistical consultation from Recipharm, and personal honoraria for manuscript writing from both Sharper Srl and Fidia Pharmaceuticals. The author has no other competing interests to declare, CS is President of Fondazione (totally supported by family). The author has no other competing interests to declare, JC received funding from National Institutes of Health (1R01HL157108-01A1,1R01AG074989-01) . The author has no other competing interests to declare, JC has received consulting honoraria from Sanifit, Bristol Myers Squibb, Merck, Edwards Lifesciences, Bayer, JNJ, Fukuda-Denshi, NGM Bio, Mayo institute of technology and the University of Delaware, and research grants from the National Institutes of Health, Abbott, Microsoft, Fukuda-Denshi and Bristol Myers Squibb. He has received compensation from the American Heart Association and the American College of Cardiology for editorial roles, and visiting speaker honoraria from Washington University, Emory University, University of Utah, the Japanese Association for Cardiovascular Nursing and the Korean Society of Cardiology. The author is named as inventor in a University of Pennsylvania patent for the use of inorganic nitrates/nitrites for the treatment of Heart Failure and Preserved Ejection Fraction and for the use of biomarkers in heart failure with preserved ejection fraction. The author has participated on the Advisory board for Bristol-Myers Squibb Data safety monitoring board for studies by the University of Delaware and UT Southwestern, and is Vice President of North American Artery Society. The author has received research device loans from Atcor Medical, Fukuda-Denshi, Unex, Uscom, NDD Medical Technologies, Microsoft, and MicroVision Medical. The author has no other competing interests to declare, LD is affiliated with BioStats Statistical Consulting Ltd where they work as a Biostatistician. The authors has received payment for statistical work for the manuscript and consulting fees from Tissue Dynamics Ltd. The author has no other competing interests to declare, OS has received consulting honoraria from Sanofi, Roche and Neopharm, and lectures honoraria from Roche . He is the chairmen of the Israel Association for the study of the liver. The author has no other competing interests to declare, YN is registered as an investor in a PCT regarding the use of metabolic regulators for COVID and has a patent on the use of PPAR agonists to treat COVID. The author has no other competing interests to declare, (© 2023, Ehrlich et al.)

Published
2023
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60. Structural-Dynamics and Binding Analysis of RBD from SARS-CoV-2 Variants of Concern (VOCs) and GRP78 Receptor Revealed Basis for Higher Infectivity.

Author

Khan A, Mohammad A, Haq I, Nasar M, Ahmad W, Yousafi Q, Suleman M, Ahmad S, Albutti A, Khan T, Marafie SK, Alshawaf E, Ali SS, Abubaker J, and Wei DQ

Abstract

Glucose-regulated protein 78 (GRP78) might be a receptor for SARS-CoV-2 to bind and enter the host cell. Recently reported mutations in the spike glycoprotein unique to the receptor-binding domain (RBD) of different variants might increase the binding and pathogenesis. However, it is still not known how these mutations affect the binding of RBD to GRP78. The current study provides a structural basis for the binding of GRP78 to the different variants, i.e., B.1.1.7, B.1.351, B.1.617, and P.1 (spike RBD), of SARS-CoV-2 using a biomolecular simulation approach. Docking results showed that the new variants bound stronger than the wild-type, which was further confirmed through the free energy calculation results. All-atom simulation confirmed structural stability, which was consistent with previous results by following the global stability trend. We concluded that the increased binding affinity of the B.1.1.7, B.1.351, and P.1 variants was due to a variation in the bonding network that helped the virus induce a higher infectivity and disease severity. Consequently, we reported that the aforementioned new variants use GRP78 as an alternate receptor to enhance their seriousness.

Published
2021
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61. Episode of Hepatitis C viral infection in the people of Swat, Pakistan.

Author

Rahat MA, Israr M, Hassan I, Islam M, -Ud-Din A, Ali A, Khan MI, Iqbal MS, Jabeen H, Rasool A, Akbar F, Khan MAA, Ullah N, Ali R, Nasar M, and Shah M

Subjects
Adolescent, Adult, Aged, Child, Female, Humans, Male, Middle Aged, Pakistan epidemiology, Prevalence, Risk Factors, Young Adult, Hepacivirus, Hepatitis C epidemiology
Abstract

Infectious agents cause serious diseases in humans worldwide and are responsible for the high rate of morbidity and mortality. The prevalence and epidemiology of infectious disease (HCV) in the hospital visited patients referred by the physicians through the initial findings and their associated risk factors were studied in Swat. The data of 174 infected patients were collected during the period of 2015 to 2017 from two clinical laboratories of Tehsil Matta Swat. Inform consent form was taken before blood collection. After taking informed consent blood samples were collected and ICT test was performed and then ICT positive cases were conform through PCR. A total of 174 ICT positive samples [106 male and 68 females] were included in this study. Age was considered from 10 to 72 years. Of the 174 ICT strip positive, 99 [63 males, 36 females] were confirmed through PCR. The prevalence rate was recorded 56.89%. I.V/I.M injection was recorded in 100% of the individuals. Visits to the barber shop was reported in (58%) of the individuals, married individuals were (81.0), surgical operation was reported in (44.8%), sharing toothbrush was observed in (29.9%), piercing was reported in (39.7%), family history was reported in (26.4%), dental treatment was observed in (21.8%), jaundice were (13.2%) and tattooing was (1.7%). Blood transfusion, surgical operations, Jaundice, family history and dental treatment were found significant risk factors for acquiring HCV infection. It was concluded that proper implementation of precautionary measures should be needed to control the spread of HCV in far near future.

Published
2021
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62. Accurate Cross-Section Estimation of Blood Vessels in Choroidal Haller's Layer: An Iterative Method based on 3D Tensor Voting.

Author

Nasar M, Vupparaboina KK, Goud A, Bashar SB, Kumar Chhablani J, and Jana S

Subjects
Algorithms, Humans, Choroid blood supply, Eye Diseases diagnostic imaging, Image Interpretation, Computer-Assisted, Tomography, Optical Coherence
Abstract

Various eye diseases, including polypoidal choroidal vasculopathy (PCV) and age-related macular degeneration (AMD), affect choroidal vasculature early, but possibly minutely. However, due to the complex networked structure of the vasculature, it becomes hard to visualize, analyze and detect such changes in 2D OCT B-scan images. In contrast, algorithmic evaluation of cross-section facilitates clinicians in tracing minute variations in the vessel network, and quantifying those correlated with pathologies, potentially leading to early diagnosis. In this context, we proposed a novel method of estimating vessel cross-sections in choroidal Haller's layer. Accuracy of our method was evaluated on synthetic as well as clinical data by trained optometrists, and earned a confidence score of 90%, marking about 60% improvement over estimates based on a well-known tree-based method.

Published
2019
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63. Occurrence of Campylobacter in retail meat in Lahore, Pakistan.

Author

Nisar M, Ahmad MUD, Mushtaq MH, Shehzad W, Hussain A, Nasar M, Nagaraja KV, and Goyal SM

Subjects
Animals, Bacterial Load, Cattle, Cross-Sectional Studies, Humans, Pakistan epidemiology, Prevalence, Zoonoses epidemiology, Campylobacter isolation & purification, Chickens microbiology, Food Contamination, Food Microbiology, Meat microbiology, Red Meat microbiology, Sheep microbiology
Abstract

Campylobacter, one of the emerging zoonotic pathogens, is worldwide in distribution. This thermo-tolerant pathogen is one of the leading causes of diarrhea and gastroenteritis in humans. The main sources of infection are contaminated meat and meat products. A cross-sectional study was conducted to estimate the prevalence of Campylobacter species in retail meat in the Lahore district of Pakistan from September 2014 to January 2015. A total of 600 samples (200 samples each of beef, mutton, and chicken) were collected from retail shops through convenience sampling and preceded for Campylobacter contamination using the ISO 10272-1:2006 (E) method. Campylobacter was present in all three types of meat; the highest prevalence being recorded in chicken meat (29%) followed by mutton (18%) and beef (15.5%). Campylobacters were isolated from 125 (20.8%) samples out of the 600 meat samples. Campylobacter jejuni was more common (74.4%) than C. coli (25.6%). The highest number of Campylobacters were isolated in September (25/125) and November (23/125) while low numbers were isolated in October and December with isolates rate of (17/125) and (19/125), respectively. The highest prevalence was seen in the oldest and overpopulated town of Data Gunj Bakhsh 16% (20/125) while lowest prevalence was seen in a newer and least populated town of Gulburg (7/125). These results indicate that Campylobacter species are circulating in various meat sources in Lahore and that it may pose a threat to public health., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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64. Association between Severity of Liver Disease, Frequency of Helicobacter pylori Infection, and Degree of Gastric Lesion in Egyptian Patients with Hepatitis B Virus Infection.

Author

Mohamed AA, Elshimy AA, El Sadik AO, Ezzat E, Nasar M, Elshaer SSM, and Sayed MM

Subjects
Adult, Case-Control Studies, Coinfection microbiology, Coinfection virology, Egypt, Female, Helicobacter Infections pathology, Helicobacter Infections virology, Helicobacter pylori, Hepatitis B microbiology, Hepatitis B pathology, Humans, Liver pathology, Liver virology, Male, Severity of Illness Index, Stomach microbiology, Coinfection pathology, Helicobacter Infections complications, Hepatitis B complications, Stomach pathology
Abstract

The relationship between hepatitis B virus (HBV) infection, severity of liver disease, frequency of Helicobacter pylori infection, and degree of gastric lesions was not yet fully investigated in Egyptian patients. The present work was performed on 100 Egyptian patients with HBV from the National Hepatology and Tropical Medicine Institute and 70 healthy volunteers as control group. The participants were subjected to full medical history taking, clinical examination, and laboratory investigations. All patients were positive for HBV surface antigen (HBV sAg), HBV DNA, and negative for hepatitis C virus antibodies. The severity of the liver disease was assessed using Child-Pugh scoring system. Screening of all participants for H. pylori Ag in stool was performed. Biopsy specimens were taken from the gastric lesions of H. pylori -infected patients for histopathological examination. The mean age of the patients and control group were 34.9 and 33.4 years, respectively. The levels of the liver enzymes were statistically higher in HBV patients than the control group. Helicobacter pylori Ag in stool was detected in 45.7% of the control group, and a higher percentage (60%) was detected in the patients group. Chronic gastritis with glandular atrophy and metaplasia was found in 15.6% of patients of Child-Pugh A, 70% of Child-Pugh B, and 100% of Child-Pugh C. It could be concluded that the prognosis of the liver disease significantly influences the severity of the gastric pathology in H. pylori infection.

Published
2018
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65. Impact of mild renal impairment on early postoperative mortality after open cardiac surgery.

Author

Ghani AA, Al Nasar M, Al Shawaf E, and Vislocky I

Subjects
Aged, Female, Glomerular Filtration Rate, Hospital Mortality, Humans, Kidney Diseases complications, Kidney Diseases physiopathology, Kidney Diseases therapy, Kuwait, Logistic Models, Male, Middle Aged, Multiple Organ Failure mortality, Renal Dialysis, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Sex Factors, Time Factors, Treatment Outcome, Cardiac Surgical Procedures mortality, Kidney physiopathology, Kidney Diseases mortality
Abstract

Preoperative severe renal impairment is included in the risk scores to predict outcome after open cardiac surgery. The purpose of this study was to assess the impact of preoperative mild renal impairment on the early postoperative mortality after open heart surgery. Data of all cases of open cardiac surgery performed from January 2005 to June 2006 were collected. Cases with preoperative creatinine clearance below 60 mL/min were excluded from the study. Data were retrospectively analyzed to find the impact of renal impairment on short-term outcome. Of the 500 cases studied, 47 had preoperative creatinine clearance between 89-60 mL/min. The overall mortality in the study cases was 6.8%. The mortality was 28.7% in those who developed postoperative ARF, 33.3% in those who required dialysis and 40.8% in those with preoperative mild renal impairment. Binary logistic regression analysis showed that female gender (P = 0.01), preoperative mild renal impairment (P = 0.007) as well as occurrence of multi organ failure (P < 0.001) were the only independent variables determining the early postoperative mortality after cardiac surgeries. Among them, preoperative mild renal impairment was the most significant and the best predictor for early postoperative mortality after cardiac surgery. Our study suggests that renal impairment remains a strong predictor of early mortality even after adjustment for several confounders.

Published
2010

66. Teratogenic effects of the anticonvulsant gabapentin in mice.

Author

Prakash, Prabhu LV, Rai R, Pai MM, Yadav SK, Madhyastha S, Goel RK, Singh G, and Nasar MA

Subjects
Animals, Body Weight, Congenital Abnormalities prevention & control, Dose-Response Relationship, Drug, Female, Gabapentin, Mice, Mice, Inbred ICR, Models, Chemical, Pregnancy, Pregnancy, Animal drug effects, Teratogens, Abnormalities, Drug-Induced, Amines adverse effects, Anticonvulsants adverse effects, Cyclohexanecarboxylic Acids adverse effects, gamma-Aminobutyric Acid adverse effects
Abstract

Introduction: We aim to study and elucidate the safety profile of the antiepileptic doses of gabapentin during pregnancy, and to evaluate gabapentin-induced murine fetotoxicity at different dose levels., Methods: A total of 60 pregnant mice, divided into 12 groups of five mice each, were exposed to gabapentin in four different doses of 0 (control), 113, 226, or 452 mg/kg body weight per day, at three different gestational stages including early gestation (1-6 days), mid-gestation (7-12 days), and late gestation (13-17 days). The pregnant mice were euthanized on day 18 of gestation, and foetuses were examined for teratogenic manifestations. Their brains were dissected and examined for gross changes, malformations, histological changes, and quantitative protein estimation., Results: Foetal resorptions were observed in all treated groups with gabapentin administration at early gestation (1-6 days), and mid-gestation (7-12 days). On the other hand, growth retardation along with stunting in size of live foetuses were observed in all the mid-gestation (7-12 days), and late gestation (13-17 days) treated groups. Various gross malformations were observed with all the three doses (113, 226, and 452 mg/kg body weight per day) when gabapentin was administered at mid-gestation (7-12 days). The same trends were confirmed by gross and microscopic examination of brains along with quantitative protein estimation., Conclusion: Gabapentin should not be prescribed during pregnancy, as no therapeutic dose of gabapentin is safe during this period as far as the foetal well-being is concerned.

Published
2008

67. Lamotrigine in pregnancy: safety profile and the risk of malformations.

Author

Prakash, Prabhu LV, Nasar MA, Rai R, Madhyastha S, and Singh G

Subjects
Animals, Anticonvulsants therapeutic use, Epilepsy drug therapy, Female, Folic Acid Deficiency chemically induced, Humans, Lamotrigine, Pregnancy, Teratogens pharmacokinetics, Teratogens pharmacology, Triazines therapeutic use, Abnormalities, Drug-Induced, Anticonvulsants adverse effects, Triazines adverse effects
Abstract

The use of antiepileptic drugs in pregnancy always presents challenges to doctors and their patients as it may have deleterious effects on the developing embryo. Lamotrigine is most commonly-prescribed drug among the newer antiepileptic drugs; hence, it has been selected for the present review. A number of studies pertaining to the safety of lamotrigine use during pregnancy have been reported, with differing results. Contradictory results have been reported in animals regarding lamotrigine teratogenicity, and human studies have also proven inconclusive. In many countries, human pregnancy registries are maintained to establish the safety of antiepileptic drugs during pregnancy, as all the different suggestions favour some over others, with specific antiepileptic combinations still being questioned. It is our hope that the present work may integrate the available disparate relevant facts into a directed effort towards minimising the risk of foetal compromise.

Published
2007

68. Hypokalaemia in the elderly: is it always diuretic-induced?

Author

Nasar MA and Lyle EM

Subjects
Aged, Aged, 80 and over, Diuretics therapeutic use, Female, Humans, Hypokalemia blood, Male, Potassium blood, Diuretics adverse effects, Hypokalemia chemically induced
Abstract

Serum potassium was measured within 24 hours in 156 patients (48 male, 108 female) with an average age of 81.9 years admitted to the unit with acute illness. Of the 156 patients, 88 (56.4%) were taking diuretics (none was on ACE inhibitors); 20 patients (12.8%) were also on digoxin therapy. In all, 24 patients (16%) had hypokalaemia and 3 (2%) hyperkalaemia. Hypokalaemia was seen in patients associated with acute illness. There was no significant difference between the diuretic and non-diuretic groups. Monitoring of serum potassium is not routinely indicated to detect hypokalaemia in patients on diuretic therapy except in those with severe hepatic or renal impairment or those on digoxin.

Published
1994

69. A comparative study of long acting diltiazem (Tildiem LA) with sustained release nifedipine (nifedipine SR) and bendrofluazide in the treatment of mild to moderate hypertension.

Author

Hosie J, Nasar MA, Belgrave GP, and Walters EG

Subjects
Adult, Aged, Aged, 80 and over, Antihypertensive Agents adverse effects, Bendroflumethiazide adverse effects, Blood Pressure drug effects, Delayed-Action Preparations, Diltiazem adverse effects, Drug Therapy, Combination, Electrolytes blood, Female, Heart Rate drug effects, Humans, Male, Middle Aged, Nifedipine adverse effects, Patient Dropouts, Antihypertensive Agents administration & dosage, Bendroflumethiazide administration & dosage, Diltiazem administration & dosage, Hypertension drug therapy, Nifedipine administration & dosage
Abstract

The therapeutic efficacy of long acting diltiazem 300 mg od (Tildiem LA) was compared with sustained release nifedipine 20 mg bd and bendrofluazide 5 mg od in a multicentre study with 230 patients diagnosed with mild to moderate essential hypertension, with 77, 77 and 76 randomized to the diltiazem, nifedipine SR and bendrofluazide groups respectively. Patients were entered into this randomised, single (investigator) blind, parallel-group multicentre study if the systolic and diastolic blood pressures were > or = 145 mm Hg and/or 95 mm Hg respectively at the admission visit. Twenty-one general practitioners and two hospital physicians monitored patients at baseline and at four and eight weeks of continuous dosing. After eight weeks of therapy, clinically acceptable control of blood pressure was seen in all groups: reductions were 19.2/13.5 mm Hg, 20.4/14 mm Hg and 18.5/10.8 mm Hg for the Tildiem, nifedipine and bendrofluazide groups respectively. Significant differences were shown between bendrofluazide and the other two groups on diastolic pressures (p = 0.01). The non-significant trend was for systolic pressures to mirror these effects. Significantly higher withdrawals caused by adverse events were seen with nifedipine. These were as follows: 14 patients receiving nifedipine (18%), 5 patients receiving diltiazem (6%) and 4 patients receiving bendrofluazide (5%). The difference in this withdrawal rate between treatments was statistically significant (p = 0.01). Post hoc tests revealed that both diltiazem and bendrofluazide had statistically significant lower withdrawals for adverse events than the nifedipine group (p = 0.047). Nifedipine was associated with a marginal increase in standing apex pulse rate and only diltiazem LA significantly maintained serum potassium levels. These results indicate that diltiazem 300 mg is an effective antihypertensive agent and is equivalent in efficacy to nifedipine SR 20 mg and both are superior to bendrofluazide. Nifedipine SR was however the worst tolerated and had the highest withdrawal rate (p = 0.013).

Published
1994

71. Cost effectiveness in treating deep pressure sores and ulcers.

Author

Nasar MA and Morley R

Subjects
Aged, Anti-Infective Agents therapeutic use, Bandages, Cost-Benefit Analysis, Granulation Tissue, Humans, Middle Aged, Paraffin therapeutic use, Pressure Ulcer pathology, Skin pathology, Borates, Detergents therapeutic use, Dextrans therapeutic use, Pressure Ulcer drug therapy, Sodium Hypochlorite, Surface-Active Agents therapeutic use
Published
1982

73. The treatment of superficial decubitus ulcers.

Author

Braverman AM and Nasar MA

Subjects
Aged, Clinical Trials as Topic, Humans, Adhesives therapeutic use, Polyurethanes therapeutic use, Pressure Ulcer therapy
Published
1981

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