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309 results on '"Naseem, Imrana"'

67. EXPLORATION OF PHYSICOCHEMICAL AND PHYTOCHEMICAL POTENTIAL OF MORINGA OLEIFERA LAM (SEHJANA) FRUITS/PODS

Author

KHAN, ZAFAR JAVED, Khan, Naeem Ahmad, Naseem, Imrana, Nami Shahab, A A, KHAN, ZAFAR JAVED, Khan, Naeem Ahmad, Naseem, Imrana, and Nami Shahab, A A

Abstract

Background: The physicochemical evaluation is an important parameter in detecting adulteration or improper handling, therefore, physicochemical and phytochemical standardization is considered a prerequisite for the assessment of biological activity and determination of biological standards of the plant material, and it provides the analytical characteristics which may prove to be useful in fixing the physicochemical standard for herbal drugs. So, it becomes imperative to standardize the drugs to ensure their identity, quality and purity to ascertain therapeutic efficacy of herbal drugs. Objective: Therefore, the present study was aimed to evaluate the physicochemical and phytochemical standardization and quality control check of an important drug Sehjana (Moringa oleifera Lam) used for various diseases, Material and Methods: The test drugs, Sehjana (Moringa oleifera Lam.) were collected directly from the herbal garden of department of Ilmul Advia AMU, Aligarh. Which includes parameters recommended by National Unani Pharmacopeia Committee, Qualitative analysis and chromatographic studies (TLC) were performed for proper identification and quality control these parameter include Results: Ash values, Total ash, (6.44%) acid insoluble ash, (3.94%) water soluble ash, (2.53%) Successive extractive values in different solvent; petroleum ether (3.03%), diethyl ether (1.3%), chloroform (1.0%), acetone (1.5%), alcohol (13.1%), aqueous (18.56%), solubility in alcohol (15.2%) and water (22.93%), loss on drying (9.13%), pH at 1% (5.45), & 10% (4.81), bulk density (0.33%) and moisture content (8.6%). Conclusion: Preliminary phytochemical analysis of Sehjana (Moringa oleifera Lam.) showed presence of alkaloid, steroids, phenol, amino acid, and terpenoids, carbohydrate and protein, which may be active compound, responsible for its wide activities.

Published
2018

68. Depleting ovarian cancer stem cells with calcitriol

Author

Srivastava, Amit Kumar, primary, Rizvi, Asim, additional, Cui, Tiantian, additional, Han, Chunhua, additional, Banerjee, Ananya, additional, Naseem, Imrana, additional, Zheng, Yanfang, additional, Wani, Altaf A., additional, and Wang, Qi-En, additional

Published
2018
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90. Vitamin D prevents glycation of proteins: an in vitro study.

Author

Iqbal, Sarah, Alam, Md. Maroof, and Naseem, Imrana

Subjects
VITAMIN D, GLYCOSYLATION, SERUM albumin, IN vitro studies, METABOLITES
Abstract

Human serum albumin ( HSA) is an important protein involved in the transport of hormones, fatty acids, drugs, and other macromolecules. Under hyperglycemic conditions, this molecule undergoes irreversible modification that affects its structure and function. In this study, we explored the effect of two forms of vitamin D, a nutraceutical, on glycation modification in HSA. The protein was incubated with a physiologically high concentration of glucose in the presence of vitamin D metabolites. After 21 days, samples were tested for secondary structural changes, side chain modification, and the presence of advanced glycation end products. Vitamin D metabolites could reduce glycation modification, albeit only to a small extent. Interaction studies reveal that Vitamin D interaction with HSA can prevent protein glycation. [ABSTRACT FROM AUTHOR]

Published
2016
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97. Morphological Perturbation of Human Erythrocytes Exposed to Photoilluminated Riboflavin.

Author

Ali, Iyad and Naseem, Imrana

Subjects
*OXYGEN in the body, *ERYTHROCYTES, *CELL morphology, *VITAMIN B2, *COPPER ions, *AMINOPHYLLINE (Drug)
Abstract

Background: Reactive oxygen species (ROS) are formed as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of oxidative stress, ROS levels can rise dramatically. This may result in significant damage to cell structures. In this work we are interested to show the effect of different ROS on the morphology of fresh human RBCs. Methods: The RBCs were incubated with different reaction mixtures at room temperature and exposed to cool fluorescent light (800 lux). Then, cells were isolated and scanned by a scanning electron microscope. Results: When incubated with photoilluminated riboflavin, RBCs lost their biconcave shape and adopted a spherocytes shape. The formation of spherocytes is usually associated with spectrin deficiency. In the presence of Cu(II) and riboflavin, RBCs appeared with spikes of different sizes on their surface showing the formation of "acanthocytes", which is usually prevalent in abetalipoprotienemia. Moreover, addition of NaN3 to riboflavin-Cu(II) system resulted in completely damaged RBCs. Away from the above combinations, when RBCs are incubated with riboflavin-aminophylline combination, they appeared with spikes of equal lengths and sizes on their surface "echinocytes", which usually appear in different diseases like pyruvate kinase deficiency and uremia. Conclusion: Red blood cells undergo different morphological changes when incubated in each of the above combinations, most probably due to the formation of different ROS and these ROS could be involved in different pathological consequences. [ABSTRACT FROM AUTHOR]

Published
2015

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