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547 results on '"Nef, Holger M."'

55. Sex Differences in Culprit Plaque Characteristics Among Different Age Groups in Patients With Acute Coronary Syndromes

Author

Seegers, Lena Marie, primary, Araki, Makoto, additional, Nakajima, Akihiro, additional, Yonetsu, Taishi, additional, Minami, Yoshiyasu, additional, Ako, Junya, additional, Soeda, Tsunenari, additional, Kurihara, Osamu, additional, Higuma, Takumi, additional, Kimura, Shigeki, additional, Adriaenssens, Tom, additional, Nef, Holger M., additional, Lee, Hang, additional, McNulty, Iris, additional, Sugiyama, Tomoyo, additional, Kakuta, Tsunekazu, additional, and Jang, Ik-Kyung, additional

Published
2022
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56. Impact of the COVID-19 pandemic on cardiovascular mortality and catherization activity during the lockdown in central Germany: an observational study

Author

Nef, Holger M., Elsässer, Albrecht, Möllmann, Helge, Abdel-Hadi, Mohammed, Bauer, Timm, Brück, Martin, Eggebrecht, Holger, Ehrlich, Joachim R., Ferrari, Markus W., Fichtlscherer, Stephan, Hink, Ulrich, Hölschermann, Hans, Kacapor, Rifat, Koeth, Oliver, Korboukov, Serguei, Lamparter, Steffen, Laspoulas, Alexander J., Lehmann, Ralf, Liebetrau, Christoph, Plücker, Tobias, Pons-Kühnemann, Jörn, Schächinger, Volker, Schieffer, Bernhard, Schott, Peter, Schulze, Matthias, Teupe, Claudius, Vasa-Nicotera, Mariuca, Weber, Michael, Weinbrenner, Christoph, Werner, Gerald, Hamm, Christian W., Dörr, Oliver, and Justus Liebig University Giessen

Subjects
Male, Cardiac Catheterization, Acute coronary syndrome, medicine.medical_specialty, Time Factors, Cardiovascular mortality, medicine.medical_treatment, Chronic coronary syndrome, 030204 cardiovascular system & hematology, Rate ratio, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Risk Factors, Cause of Death, Germany, Internal medicine, Pandemic, Humans, Medicine, Hospital Mortality, 030212 general & internal medicine, SARS-CoV2 pandemic, Aged, Cause of death, Cardiac catheterization, ddc:610, Original Paper, business.industry, COVID-19, Percutaneous coronary intervention, General Medicine, Middle Aged, medicine.disease, Confidence interval, Hospitalization, Cardiovascular Diseases, Emergency medicine, Cardiology, Female, Observational study, Cardiology and Cardiovascular Medicine, business
Abstract

Aims During the COVID-19 pandemic, hospital admissions for cardiac care have declined. However, effects on mortality are unclear. Thus, we sought to evaluate the impact of the lockdown period in central Germany on overall and cardiovascular deaths. Simultaneously we looked at catheterization activities in the same region. Methods and results Data from 22 of 24 public health-authorities in central Germany were aggregated during the pandemic related lockdown period and compared to the same time period in 2019. Information on the total number of deaths and causes of death, including cardiovascular mortality, were collected. Additionally, we compared rates of hospitalization (n = 5178) for chronic coronary syndrome (CCS), acute coronary syndrome (ACS), and out of hospital cardiac arrest (OHCA) in 26 hospitals in this area. Data on 5,984 deaths occurring between March 23, 2020 and April 26, 2020 were evaluated. In comparison to the reference non-pandemic period in 2019 (deaths: n = 5832), there was a non-significant increase in all-cause mortality of 2.6% [incidence rate ratio (IRR) 1.03, 95% confidence interval (CI) 0.99–1.06; p = 0.16]. Cardiovascular and cardiac mortality increased significantly by 7.6% (IRR 1.08, 95%-CI 1.01–1.14; p = 0.02) and by 11.8% (IRR 1.12, 95%-CI 1.05–1.19; p Conclusion During the COVID-19-related lockdown a significant increase in cardiovascular mortality was observed in central Germany, whereas catherization activities were reduced. The mechanisms underlying both of these observations should be investigated further in order to better understand the effects of a pandemic-related lockdown and social-distancing restrictions on cardiovascular care and mortality. Graphic abstract

Published
2020
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58. Outcomes of 10,312 patients treated with everolimus-eluting bioresorbable scaffolds during daily clinical practice – results from the European Absorb Consortium

Author

Wiebe, Jens, Hofmann, Felix J., West, Nick, Baumbach, Andreas, Carrie, Didier, Bermudez, Eduardo Pinar, Cayla, Guillaume, Hernandez, Felipe Hernandez, Torre Hernandez, Jose M., Koning, René, Loi, Bruno, Moscarella, Elisabetta, Tarantini, Giuseppe, Zaman, Azfar, Lober, Christiane, Riemer, Thomas, Achenbach, Stephan, Hamm, Christian W., Nef, Holger M., and Justus Liebig University Giessen

Subjects
ddc:610
Published
2022
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63. First case report of fully robotically assisted lithotripsy in heavily calcified left main stenosis.

Author

Hofmann, Felix J, Dörr, Oliver, Blachutzik, Florian, Boeder, Niklas F, Elsässer, Albrecht, Möllmann, Helge, and Nef, Holger M

Subjects
CORONARY artery disease, PERCUTANEOUS coronary intervention, CORONARY artery calcification, LITHOTRIPSY, STENOSIS
Abstract

Background Percutaneous coronary intervention (PCI) is the standard-of-care treatment for left main stenosis as an alternative to bypass surgery. In addition, severe coronary lesion calcification can be modified by intravascular lithotripsy (IVL). However, with PCI and debulking treatment options, there are inherent limitations. PCI poses an increased health burden for the treating physician that is associated with wearing a heavy, lead-lined apron and being exposed to radiation. To overcome these issues, a robotically assisted angioplasty system (rPCI) was established that enables the operator to perform PCI remotely in routine clinical procedures. Furthermore, IVL have not been used remotely. Case summary Here, we report the use of this technique for treating a heavily calcified left main stenosis in an 82-year-old male with previously diagnosed two-vessel coronary artery disease, progressive symptoms of dyspnoea at high cardio-vascular risk profile. The decision of the local heart team declined surgery. To the best of our knowledge, this is the first report of successful rPCI combined with IVL. Discussion In the case presented, rPCI was feasible and safe even in a complex lesion of the left main coronary artery requiring IVL. rPCI is a revolutionary new technique that may be applied to various types of coronary artery lesions. [ABSTRACT FROM AUTHOR]

Published
2023
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64. Acute Mechanical Performance of Magmaris vs. DESolve Bioresorbable Scaffolds in a Real-World Scenario

Author

Boeder, Niklas F., Dörr, Oliver, Koepp, Tim, Blachutzik, Florian, Achenbach, Stephan, Elsässer, Albrecht, Hamm, Christian W., and Nef, Holger M.

Subjects
Magmaris sirolimus-eluting bioresorbable scaffold, ddc:610, Cardiovascular Medicine, bioresorbable scaffold, optical coherance tomography, coronary heart disease, coronary imaging, Original Research
Abstract

Background: After the bioresorbable PLLA-based vascular scaffold (Absorb BVS) was taken from the market due to its high adverse event rates, a magnesium-based scaffold (Magmaris) was introduced. Objective: To compare the acute performance of the sirolimus-eluting magnesium alloy Magmaris scaffold with that of the novolimus-eluting PLLA-based DESolve scaffold in terms of appropriate scaffold deployment using optical coherence tomography (OCT). Methods and Results: Data from the final OCT pullback of 98 patients were included (19 Magmaris, 79 DESolve) and analyzed at 1-mm intervals. The following indices were calculated: mean and minimal area, residual area stenosis, incomplete strut apposition, tissue prolapse, eccentricity index, symmetry index, strut fracture, and edge dissection. OCT showed a minimum lumen area for Magmaris vs. DESolve of 6.6 ± 1.6 vs. 6.0 ± 1.9 (p = 0.06). Scaffolds with residual area stenosis >20% were predominantly seen in the DESolve group (15.8 vs. 46.8%; p = 0.01). The mean eccentricity index did differ significantly (0.74 ± 0.06 vs. 0.63 ± 0.09; p < 0.001). No fractures were observed for Magmaris scaffolds, but 15.2% were documented for DESolve BRS (p < 0.001). Incomplete scaffold apposition area was significantly higher in the DESolve group (0.01 ± 0.02 vs. 1.05 ± 2.32 mm2; p < 0.001). Conclusion: This is the first study to compare the acute mechanical performance between Magmaris and DESolve in a real-world setting. The acute mechanical performance of Magmaris BRS seems to be superior to that of DESolve BRS, whereas OCT showed a good acute mechanical performance for both BRS in terms of generally accepted imaging criteria.

Published
2021

66. No difference in 30-day outcome and quality of life in transradial versus transfemoral access – Results from the German Austrian ABSORB registry (GABI-R)

Author

Wein, Bastian, primary, Zaczkiewicz, Myron, additional, Graf, Matthias, additional, Zimmermann, Oliver, additional, Gori, Tommaso, additional, Nef, Holger M., additional, Kastner, Johannes, additional, Mehilli, Julinda, additional, Richardt, Gert, additional, Wöhrle, Jochen, additional, Achenbach, Stephan, additional, Riemer, Thomas, additional, Hamm, Christian, additional, and Torzewski, Jan, additional

Published
2021
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67. Age and Phenotype of Patients With Plaque Erosion

Author

Araki, Makoto, primary, Yonetsu, Taishi, additional, Kurihara, Osamu, additional, Nakajima, Akihiro, additional, Lee, Hang, additional, Soeda, Tsunenari, additional, Minami, Yoshiyasu, additional, Higuma, Takumi, additional, Kimura, Shigeki, additional, Takano, Masamichi, additional, Yan, Bryan P., additional, Adriaenssens, Tom, additional, Boeder, Niklas F., additional, Nef, Holger M., additional, Kim, Chong Jin, additional, McNulty, Iris, additional, Crea, Filippo, additional, Kakuta, Tsunekazu, additional, and Jang, Ik‐Kyung, additional

Published
2021
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83. Comprehensive work up of right ventricular reverse remodelling after successful pulmonary endarterectomy for chronic thrombembolic pulmonary hypertension - a cardiac magnetic resonance study

Author

Rolf Andreas, Guth Stefan, Boergel Johannes, Rixe Johannes, Nef Holger M, Liebetrau Christoph, Szardien Sebastian, Kramm Thorsten H, Krombach Grabriele A, Mayer Eckhard, and Hamm Christian

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2013
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84. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients

Author

Pelliccia, Francesco, Parodi, Guido, Greco, Cesare, Antoniucci, David, Brenner, Roman, Bossone, Eduardo, Cacciotti, Luca, Capucci, Alessandro, Citro, Rodolfo, Delmas, Clément, Guerra, Federico, Ionescu, Costin N., Lairez, Olivier, Larrauri-Reyes, Maiteder, Lee, Pil Hyung, Mansencal, Nicolas, Marazzi, Giuseppe, Mihos, Christos G., Morel, Olivier, Nef, Holger M., Nunez Gil, Ivan J., Passaseo, Ilaria, Pineda, Andres M., Rosano, Giuseppe, Santana, Orlando, Schneck, Franziska, Song, Bong Gun, Song, Jae-Kwan, Teh, Andrew W., Ungprasert, Patompong, Valbusa, Alberto, Wahl, Andreas, Yoshida, Tetsuro, Gaudio, Carlo, and Kaski, Juan Carlos

Published
2015
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86. Clinical and Laboratory Predictors for Plaque Erosion in Patients With Acute Coronary Syndromes

Author

Massachusetts Institute of Technology. Research Laboratory of Electronics, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Yamamoto, Erika, Yonetsu, Taishi, Kakuta, Tsunekazu, Soeda, Tsunenari, Saito, Yoshihiko, Yan, Bryan P., Kurihara, Osamu, Takano, Masamichi, Niccoli, Giampaolo, Higuma, Takumi, Kimura, Shigeki, Minami, Yoshiyasu, Ako, Junya, Adriaenssens, Tom, Boeder, Niklas F., Nef, Holger M., Fracassi, Francesco, Sugiyama, Tomoyo, Lee, Hang, Crea, Filippo, Kimura, Takeshi, Fujimoto, James G, Fuster, Valentin, Jang, Ik‐Kyung, Massachusetts Institute of Technology. Research Laboratory of Electronics, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Yamamoto, Erika, Yonetsu, Taishi, Kakuta, Tsunekazu, Soeda, Tsunenari, Saito, Yoshihiko, Yan, Bryan P., Kurihara, Osamu, Takano, Masamichi, Niccoli, Giampaolo, Higuma, Takumi, Kimura, Shigeki, Minami, Yoshiyasu, Ako, Junya, Adriaenssens, Tom, Boeder, Niklas F., Nef, Holger M., Fracassi, Francesco, Sugiyama, Tomoyo, Lee, Hang, Crea, Filippo, Kimura, Takeshi, Fujimoto, James G, Fuster, Valentin, and Jang, Ik‐Kyung

Abstract

Background: Plaque erosion is responsible for 25% to 40% of patients with acute coronary syndromes (ACS). Recent studies suggest that anti-thrombotic therapy without stenting may be an option for this subset of patients. Currently, however, an invasive procedure is required to make a diagnosis of plaque erosion. The aim of this study was to identify clinical or laboratory predictors of plaque erosion in patients with ACS to enable a diagnosis of erosion without additional invasive procedures. Methods and Results: Patients with ACS who underwent optical coherence tomography imaging were selected from 11 institutions in 6 countries. The patients were classified into plaque rupture, plaque erosion, or calcified plaque, and predictors were identified using multivariable logistic modeling. Among 1241 patients with ACS, 477 (38.4%) patients were found to have plaque erosion. Plaque erosion was more frequent in non–ST-segment elevation-ACS than in ST-segment–elevation myocardial infarction (47.9% versus 29.8%, P=0.0002). Multivariable logistic regression models showed 5 independent parameters associated with plaque erosion: age <68 years, anterior ischemia, no diabetes mellitus, hemoglobin >15.0 g/dL, and normal renal function. When all 5 parameters are present in a patient with non–ST-segment elevation-ACS, the probability of plaque erosion increased to 73.1%. Conclusions: Clinical and laboratory parameters associated with plaque erosion are explored in this retrospective registry study. These parameters may be useful to identify the subset of ACS patients with plaque erosion and guide them to conservative management without invasive procedures. The results of this exploratory analysis need to be confirmed in large scale prospective clinical studies. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT03479723.

Published
2021

95. Regression of cardiac hypertrophy by granulocyte colony-stimulating factor-stimulated interleukin-1β synthesis

Author

Szardien, Sebastian, Nef, Holger M., Voss, Sandra, Troidl, Christian, Liebetrau, Christoph, Hoffmann, Jedrzej, Rauch, Maximilian, Mayer, Katharina, Kimmich, Kathrin, Rolf, Andreas, Rixe, Johannes, Troidl, Kerstin, Kojonazarov, Baktybek, Schermuly, Ralph T., Kostin, Sawa, Elsässer, Albrecht, Hamm, Christian W., and Möllmann, Helge

Published
2012
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100. Determinants of ST-segment elevation myocardial infarction as clinical presentation of acute coronary syndrome

Author

Kurihara, Osamu, primary, Takano, Masamichi, additional, Kakuta, Tsunekazu, additional, Soeda, Tsunenari, additional, Crea, Filippo, additional, Adriaenssens, Tom, additional, Nef, Holger M., additional, Boeder, Niklas F., additional, Yamamoto, Erika, additional, Kim, Hyung Oh, additional, Russo, Michele, additional, McNulty, Iris, additional, Araki, Makoto, additional, Nakajima, Akihiro, additional, Lee, Hang, additional, Mizuno, Kyoichi, additional, and Jang, Ik -Kyung, additional

Published
2020
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