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1,792 results on '"Noble, James"'

61. Design and Methods of the Early Age-Related Hearing Loss Investigation Randomized Controlled Trial

Author

Denham, Michael W., primary, Arnold, Michelle L., additional, Sanchez, Victoria A., additional, Lin, Frank R., additional, Gomez, Michael C., additional, Neil, Haley, additional, Boyle, Suzannah, additional, Selevan, Sally, additional, Sussman, Tamara J., additional, Fine, Ione, additional, Glynn, Nancy W., additional, Teresi, Jeanne, additional, Noble, James M., additional, Goldberg, Terry, additional, Luchsinger, Jose A., additional, and Golub, Justin S., additional

Published
2024
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62. Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease

Author

Brown, Belinda M, Sohrabi, Hamid R, Taddei, Kevin, Gardener, Samantha L, Rainey‐Smith, Stephanie R, Peiffer, Jeremiah J, Xiong, Chengjie, Fagan, Anne M, Benzinger, Tammie, Buckles, Virginia, Erickson, Kirk I, Clarnette, Roger, Shah, Tejal, Masters, Colin L, Weiner, Michael, Cairns, Nigel, Rossor, Martin, Graff‐Radford, Neill R, Salloway, Stephen, Vöglein, Jonathan, Laske, Christoph, Noble, James, Schofield, Peter R, Bateman, Randall J, Morris, John C, and Martins, Ralph N

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Alzheimer's Disease, Brain Disorders, Acquired Cognitive Impairment, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Aging, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adult, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Aniline Compounds, Apolipoproteins E, Brain, Cohort Studies, Cross-Sectional Studies, Exercise, Female, Genotype, Humans, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Peptide Fragments, Positron-Emission Tomography, Presenilin-1, Presenilin-2, Surveys and Questionnaires, Thiazoles, tau Proteins, Physical activity, Amyloid beta, Genetics, Tau, Alzheimer's disease, Dominantly Inherited Alzheimer Network, Amyloid β, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionThe objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers.MethodsIn 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression.ResultsNo differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels.DiscussionOur findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.

Published
2017

63. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease

Author

Allegri, Ricardo, Amtashar, Fatima, Bateman, Randy, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chhatwal, Jasmeer, Chrem, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, Cruchaga, Carlos, D‘Mello, Mirelle, Donahue, Tamara, Douglas, Jane, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldman, Jill, Gordon, Brian, Graff-Radford, Neill, Gray, Julia, Gurney, Jenny, Hassenstab, Jason, Hirohara, Mie, Holtzman, David, Hornbeck, Russ, DiBari, Siri Houeland, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Jucker, Mathias, Karch, Celeste, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William (Bill), Koeppe, Robert, Kuder-Buletta, Elke, Laske, Christoph, Lee, Jae-Hong, Levin, Johannes, Marcus, Daniel, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Maue-Dreyfus, Denise, McDade, Eric, Montoya, Lucy, Mori, Hiroshi, Morris, John, Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Norton, Joanne, Perrin, Richard, Raichle, Marc, Ringman, John, Roh, Jee Hoon, Salloway, Stephen, Schofield, Peter, Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Wang, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xiong, Chengjie, Xu, Xiong, Tam, Angela, Labonté, Anne, Pichet Binette, Alexa, Faubert, Anne-Marie, Mathieu, Axel, Madjar, Cécile, Carrier, Charles Edouard, Dansereau, Christian, Kazazian, Christina, Lepage, Claude, Picard, Cynthia, Maillet, David, Michaud, Diane, Couture, Doris, Dea, Doris, Cuello, Claudio, Barkun, Alan, Evans, Alan, Courcot, Blandine, Tardif, Christine, Debacker, Clément, Jack, Clifford R., Fontaine, David, Knopman, David S., Maultaup, Gerhard, Near, Jamie, Leoutsakos, Jeannie-Marie, Maltais, Jean-Robert, Brandt, Jason, Pruessner, Jens, Morris, John C., Breitner, John C.S., Poirier, Judes, Cheewakriengkrai, Laksanun, Münter, Lisa-Marie, Collins, Louis, Chakravarty, Mallar, Sager, Mark A., Dauar-Tedeschi, Marina, Eisenberg, Mark, Rajah, Natasha, Aisen, Paul, Toussaint, Joanne, Rosa-Neto, Pedro, Bellec, Pierre, Kostopoulos, Penelope, Etienne, Pierre, Tariot, Pierre N., Orban, Pierre, Sperling, Reisa A., Hoge, Rick, Thomas, Ronald G., Gauthier, Serge, Craft, Suzanne, Villeneuve, Sylvia, Montine, Thomas J., Nair, Vasavan, Bohbot, Véronique, Venugopalan, Vinod, Fonov, Vladimir, Ituria-Medina, Yasser, Khachaturian, Zaven S., Teigner, Eduard, Anthal, Elena, Yu, Elsa, Ferdinand, Fabiola, Pogossova, Galina, Mayrand, Ginette, Duclair, Guerda, Gagné, Guylaine, Newbold-Fox, Holly, Leppert, Illana, Vallée, Isabelle, Vogel, Jacob W., Tremblay-Mercier, Jennifer, Frenette, Joanne, Frappier, Josée, Kat, Justin, Miron, Justin, Wan, Karen, Mahar, Laura, Carmo, Leopoldina, Théroux, Louise, Dadar, Mahsa, Dufour, Marianne, Lafaille-Magnan, Marie-Elyse, Appleby, Melissa, Savard, Mélissa, Tuwaig, Miranda, Petkova, Mirela, Rioux, Pierre, Meyer, Pierre-François, El-Khoury, Rana, Gordon, Renee, Giles, Renuka, Das, Samir, Wang, Seqian, Tabrizi, Shirin, Mathotaarachchi, Sulantha, Dubuc, Sylvie, Lee, Tanya, Beaudry, Thomas, Gervais, Valérie, Pagé, Véronique, Gonneaud, Julie, Ayranci, Gülebru, Pascoal, Tharick A., Desautels, René, Benbouhoud, Fatiha, Saint-Fort, Eunice Farah, Verfaillie, Sander C.J., Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Vachon-Presseau, Etienne, Daoust, Leslie-Ann, Köbe, Theresa, Spreng, Nathan, McSweeney, Melissa, Nilsson, Nathalie, Pishnamazi, Morteza, Bedetti, Christophe, Vachon-Presseau, Étienne, Bateman, Randall, and Collins, D. Louis

Published
2021
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64. The Essence of Inheritance

Author

Black, Andrew P., Bruce, Kim B., and Noble, James

Subjects
Computer Science - Programming Languages
Abstract

Programming languages serve a dual purpose: to communicate programs to computers, and to communicate programs to humans. Indeed, it is this dual purpose that makes programming language design a constrained and challenging problem. Inheritance is an essential aspect of that second purpose: it is a tool to improve communication. Humans understand new concepts most readily by first looking at a number of concrete examples, and later abstracting over those examples. The essence of inheritance is that it mirrors this process: it provides a formal mechanism for moving from the concrete to the abstract., Comment: This paper was submitted for inclusion in a Festschrift entitled "A list of successes that can change the world", to be published by Springer

Published
2016

68. Using Natural Language Processing to Identify Home Health Care Patients at Risk for Diagnosis of Alzheimer's Disease and Related Dementias.

Author

Ryvicker, Miriam, Barrón, Yolanda, Song, Jiyoun, Zolnoori, Maryam, Shah, Shivani, Burgdorf, Julia G., Noble, James M., and Topaz, Maxim

Abstract

This study aimed to: (1) validate a natural language processing (NLP) system developed for the home health care setting to identify signs and symptoms of Alzheimer's disease and related dementias (ADRD) documented in clinicians' free-text notes; (2) determine whether signs and symptoms detected via NLP help to identify patients at risk of a new ADRD diagnosis within four years after admission. This study applied NLP to a longitudinal dataset including medical record and Medicare claims data for 56,652 home health care patients and Cox proportional hazard models to the subset of 24,874 patients admitted without an ADRD diagnosis. Selected ADRD signs and symptoms were associated with increased risk of a new ADRD diagnosis during follow-up, including: motor issues; hoarding/cluttering; uncooperative behavior; delusions or hallucinations; mention of ADRD disease names; and caregiver stress. NLP can help to identify patients in need of ADRD-related evaluation and support services. [ABSTRACT FROM AUTHOR]

Published
2024
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70. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

Author

Doering, Stephanie, primary, McCullough, Austin, additional, Gordon, Brian A., additional, Chen, Charles D., additional, McKay, Nicole, additional, Hobbs, Diana, additional, Keefe, Sarah, additional, Flores, Shaney, additional, Scott, Jalen, additional, Smith, Hunter, additional, Jarman, Stephen, additional, Jackson, Kelley, additional, Hornbeck, Russ C., additional, Ances, Beau M., additional, Xiong, Chengjie, additional, Aschenbrenner, Andrew J., additional, Hassenstab, Jason, additional, Cruchaga, Carlos, additional, Daniels, Alisha, additional, Bateman, Randall J., additional, Noble, James M., additional, Day, Gregory S., additional, Graff-Radford, Neill R., additional, Voglein, Jonathan, additional, Levin, Johannes, additional, Allegri, Ricardo F., additional, Mendez, Patricio Chrem, additional, Surace, Ezequiel, additional, Berman, Sarah B., additional, Ikonomovic, Snezana, additional, Nadkarni, Neelesh K., additional, Lopera, Francisco, additional, Ramirez, Laura, additional, Aguillon, David, additional, Leon, Yudy, additional, Ramos, Claudia, additional, Alzate, Diana, additional, Baena, Ana, additional, Londono, Natalia, additional, Moreno, Sonia, additional, Jucker, Mathias, additional, Laske, Christoph, additional, Kuder-Buletta, Elke, additional, Graber-Sultan, Susanne, additional, Preische, Oliver, additional, Hofmann, Anna, additional, Ikeuchi, Takeshi, additional, Kasuga, Kensaku, additional, Niimi, Yoshiki, additional, Ishii, Kenji, additional, Senda, Michio, additional, Sanchez-Valle, Raquel, additional, Rosa-Neto, Pedro, additional, Fox, Nick C., additional, Cash, Dave, additional, Lee, Jae-Hong, additional, Roh, Jee Hoon, additional, Salloway, Stephen, additional, Riddle, Meghan C., additional, Menard, William, additional, Bodge, Courtney, additional, Surti, Mustafa, additional, Takada, Leonel Tadao, additional, Farlow, Martin, additional, Chhatwal, Jasmeer P., additional, Sanchez-Gonzalez, V.J., additional, Orozco-Barajas, Maribel, additional, Goate, Alison M., additional, Renton, Alan E., additional, Esposito, Bianca T., additional, Karch, Celeste M., additional, Marsh, Jacob, additional, Fernanadez, Victoria, additional, Fagan, Anne M., additional, Jerome, Gina, additional, Herries, Elizabeth, additional, Llibre-Guerra, Jorge, additional, Levey, Allan I., additional, Johnson, Erik C.B., additional, Seyfried, Nicholas T., additional, Schofield, Peter R., additional, Brooks, William S., additional, Bechara, Jacob A., additional, Bateman, Randall, additional, McDade, Eric, additional, Perrin, Richard J., additional, Franklin, Erin E., additional, Benzinger, Tammie, additional, Chen, Allison, additional, Chen, Charles, additional, Friedrichsen, Nelly, additional, Gordon, Brian, additional, Hantler, Nancy, additional, Hornbeck, Russ, additional, Jarman, Steve, additional, Koudelis, Deborah, additional, Massoumzadeh, Parinaz, additional, Nicklaus, Joyce, additional, Pulizos, Christine, additional, Wang, Qing, additional, Mishall, Sheetal, additional, Sabaredzovic, Edita, additional, Deng, Emily, additional, Candela, Madison, additional, Wang, Peter, additional, Xu, Xiong, additional, Li, Yan, additional, Gremminger, Emily, additional, Ma, Yinjiao, additional, Bui, Ryan, additional, Lu, Ruijin, additional, Martins, Ralph, additional, Sosa Ortiz, Ana Luisa, additional, Courtney, Laura, additional, Mori, Hiroshi, additional, Supnet-Bell, Charlene, additional, Xu, Jinbin, additional, Ringman, John, additional, Barthelemy, Nicolas, additional, Morris, John, additional, Smith, Jennifer, additional, Morris, John C., additional, and Benzinger, Tammie L.S., additional

Published
2024
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72. The Faultless Way of Programming : Principles, Patterns, Practices, and Peculiarities for Verification in Dafny

Author

Noble, James, Weir, Charles, Noble, James, and Weir, Charles

Abstract

There is one faultless way of programming. It uses computer intelligence to validate computer code: formal verification. Yet for developers this faultless approach has remained alien, incomprehensible, and many miss out on its proven benefits. This set of patterns introduces Dafny to developers. Dafny provides a powerful way to incorporate formal verification into software that is integrated with languages like Java and C#, generating code that is provably free from defects and problems. The patterns range from the Dafny design philosophy to concepts like ghost variables and implementation details such as the use of generative artificial intelligence. By offering an accessible approach to a difficult subject, they support developers in producing faultless code.

Published
2024

73. Dafny vs. Dala: Experience with Mechanising Language Design

Author

Noble, James, Mackay, Julian, Wrigstad, Tobias, Fawcet, Andrew, Homer, Michael, Noble, James, Mackay, Julian, Wrigstad, Tobias, Fawcet, Andrew, and Homer, Michael

Abstract

Dala is a design for a concurrent dynamic object-oriented language. A key goal of Dala's design is to avoid data races, by ensuring threads do not share mutable state. In this paper we discuss our experience using the program verification tool Dafny to validate Dala's design. We explain how we modelled salient features of Dala in Dafny, and how Dafny did (or did not) assist our confidence in Dala's design.

Published
2024
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74. A rapid environmental risk assessment of the Kakhovka Dam breach during the Ukraine conflict [Correspondence]

Author

Spears, Bryan M., Harpham, Quillon, Brown, Emma, Barnett, Catherine L., Barwell, Louise, Collell, Marta Roca, Davison, Mark, Dixon, Harry, Elliott, J. Alex, Garbutt, Angus, Hazlewood, Caroline, Hofmann, Barbara, Lanyon, James, Lofts, Stephen, MacKechnie, Colin, Medinets, Sergiy, Noble, James, Ramsbottom, David, Redhead, John W., Riera, Alberto, Spurgeon, David J., Svendsen, Claus, Taylor, Philip, Thackeray, Stephen J., Turvey, Katharine, Wood, Michael D., Spears, Bryan M., Harpham, Quillon, Brown, Emma, Barnett, Catherine L., Barwell, Louise, Collell, Marta Roca, Davison, Mark, Dixon, Harry, Elliott, J. Alex, Garbutt, Angus, Hazlewood, Caroline, Hofmann, Barbara, Lanyon, James, Lofts, Stephen, MacKechnie, Colin, Medinets, Sergiy, Noble, James, Ramsbottom, David, Redhead, John W., Riera, Alberto, Spurgeon, David J., Svendsen, Claus, Taylor, Philip, Thackeray, Stephen J., Turvey, Katharine, and Wood, Michael D.

Published
2024

79. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

Author

Schindler, Suzanne E., Li, Yan, Todd, Kaitlin W., Herries, Elizabeth M., Henson, Rachel L., Gray, Julia D., Wang, Guoqiao, Graham, Danielle L., Shaw, Leslie M., Trojanowski, John Q., Hassenstab, Jason J., Benzinger, Tammie L.S., Cruchaga, Carlos, Jucker, Mathias, Levin, Johannes, Chhatwal, Jasmeer P., Noble, James M., Ringman, John M., Graff-Radford, Neill R., Holtzman, David M., Ladenson, Jack H., Morris, John C., Bateman, Randall J., Xiong, Chengjie, and Fagan, Anne M.

Published
2019
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80. Seizures as an early symptom of autosomal dominant Alzheimer's disease

Author

Vöglein, Jonathan, Noachtar, Soheyl, McDade, Eric, Quaid, Kimberly A., Salloway, Stephen, Ghetti, Bernardino, Noble, James, Berman, Sarah, Chhatwal, Jasmeer, Mori, Hiroshi, Fox, Nick, Allegri, Ricardo, Masters, Colin L., Buckles, Virginia, Ringman, John M., Rossor, Martin, Schofield, Peter R., Sperling, Reisa, Jucker, Mathias, Laske, Christoph, Paumier, Katrina, Morris, John C., Bateman, Randall J., Levin, Johannes, and Danek, Adrian

Published
2019
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81. Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging

Author

Rubinstein, Tom, primary, Brickman, Adam M., additional, Cheng, Bin, additional, Burkett, Sandra, additional, Park, Heekuk, additional, Annavajhala, Medini K., additional, Uhlemann, Anne‐Catrin, additional, Andrews, Howard, additional, Gutierrez, Jose, additional, Paster, Bruce J., additional, Noble, James M., additional, and Papapanou, Panos N., additional

Published
2024
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82. Hyperspectral Mapping of Human Primary and Stem Cells at Cell–Matrix Interfaces

Author

De Santis, Emiliana, primary, Faruqui, Nilofar, additional, Russell, Craig T., additional, Noble, James E., additional, Kepiro, Ibolya E., additional, Hammond, Katharine, additional, Tsalenchuk, Maria, additional, Ryadnov, Eugeni M., additional, Wolna, Magda, additional, Frogley, Mark D., additional, Price, Christopher J., additional, Barbaric, Ivana, additional, Cinque, Gianfelice, additional, and Ryadnov, Maxim G., additional

Published
2024
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84. Refinement of Neurofilament light Dynamics in CSF and Blood for familial Alzheimer’s Disease

Author

Hofmann, Anna, primary, Haesler, Lisa M., additional, Preische, Oliver, additional, Gräber‐Sultan, Susanne, additional, Obermüller, Ulrike, additional, Vöglein, Jonathan, additional, Levin, Johannes, additional, Laske, Christoph, additional, Fitzpatrick, Colleen D, additional, Levin, Raina, additional, Joseph‐Mathurin, Nelly, additional, Chen, Charles D., additional, Cruchaga, Carlos, additional, Goate, Alison, additional, Allegri, Ricardo Francisco, additional, Benzinger, Tammie L.S., additional, Berman, Sarah, additional, Chui, Helena C, additional, Fagan, Anne M., additional, Farlow, Martin R., additional, Fox, Nick C, additional, Day, Gregory S., additional, Hassenstab, Jason J., additional, Jack, Clifford R., additional, Lee, Jae‐Hong, additional, Levey, Allan I., additional, Martins, Ralph N, additional, Mori, Hiroshi, additional, Noble, James M, additional, Perrin, Richard J., additional, Sperling, Reisa A., additional, Rosa‐Neto, Pedro, additional, Salloway, Stephen, additional, Sanchez‐Valle, Raquel, additional, Schofield, Peter R, additional, Xiong, Chengjie, additional, Karch, Celeste M., additional, Graff‐Radford, Neill R, additional, Gordon, Brian A., additional, Morris, John C, additional, McDade, Eric, additional, Bateman, Randall J., additional, Chhatwal, Jasmeer P., additional, Jucker, Mathias, additional, and Schultz, Stephanie A., additional

Published
2023
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88. Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

Author

Joseph-Mathurin, Nelly, Su, Yi, Blazey, Tyler M., Jasielec, Mateusz, Vlassenko, Andrei, Friedrichsen, Karl, Gordon, Brian A., Hornbeck, Russ C., Cash, Lisa, Ances, Beau M., Veale, Thomas, Cash, David M., Brickman, Adam M., Buckles, Virginia, Cairns, Nigel J., Cruchaga, Carlos, Goate, Alison, Jack, Clifford R., Jr., Karch, Celeste, Klunk, William, Koeppe, Robert A., Marcus, Daniel S., Mayeux, Richard, McDade, Eric, Noble, James M., Ringman, John, Saykin, Andrew J., Thompson, Paul M., Xiong, Chengjie, Morris, John C., Bateman, Randall J., and Benzinger, Tammie L.S.

Published
2018
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97. Understanding Ownership Types with Dependent Types

Author

Cameron, Nicholas, Drossopoulou, Sophia, Noble, James, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Clarke, Dave, editor, Noble, James, editor, and Wrigstad, Tobias, editor

Published
2013
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98. Beyond the Geneva Convention on the Treatment of Object Aliasing

Author

Clarke, Dave, Noble, James, Wrigstad, Tobias, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Clarke, Dave, editor, Noble, James, editor, and Wrigstad, Tobias, editor

Published
2013
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