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Copyright of Journal of Clinical Dentistry & Research is the property of Dental Press International and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Intraosseous mucoepidermoid carcinoma (MEC) is a rare neoplasm of the jaws with uncertain pathogenesis. We present the case of a 48-year-old female patient who underwent evaluation of a bone defect on the left side of the jaw found during a routine imaging exam. The radiological examination revealed a well-defined unilocular radiolucent lesion with irregular margins. An excisional biopsy with an exploratory puncture was performed. Histopathological examination revealed a malignant neoplasm of glandular origin with three distinct cell morphologies: epidermoid, intermediate, and mucous. These cells permeate the stroma forming multiple cystic, sometimes filled with mucus and delimited by mucous and intermediate cells. Strong PAS-positivity demonstrated mucin areas. The diagnosis of MEC was established based on these findings. Although the intraosseous appearance is rare, MEC should be included in the differential diagnosis of bone pathologies. [ABSTRACT FROM AUTHOR]

Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm originally described in pleura with rare presentation in oral cavity. Herein, we showed a case of a 28-year-old male patient who presented an asymptomatic slow-growing mass in the anterior part of the tongue. Intraoral examination revealed a well circumscribed mass covered by normal mucosa with fibrous consistency. Due to nonspecific clinical findings, the initial diagnostic hypotheses include several submucosal neoplasms such as leiomyoma, neurofibroma, and others. An excisional biopsy was performed. Microscopically, the tumor was surrounded by a thick fibrous capsule, and hypo- and hypercellular areas were arranged in a storiform pattern with a stroma formed by collagen and abundant vascularization. Tumor cells showed immunopositivity for CD34 and CD99, and no expression of AML, S-100, or Ki-67. According to these findings, the diagnosis of STF was established. Although oral involvement is rare, STF should be included in the differential diagnosis of submucosal oral lesions. [ABSTRACT FROM AUTHOR]

Objective: Possible differences in splicing variants of TGIF1 in oral squamous cell carcinoma (OSCC) have not yet been reported. This study analyzed the expression levels of different splicing variants of the TGIF1 gene in OSCC compared with nontumoral epithelium (NT) and the relationship with clinical-pathologic features of tumors. Study Design: Forty-eight frozen samples of OSCC and 17 of NT were analyzed using quantitative reverse transcription polymerase chain reaction. Results: TGIF1v2 and v8 are overexpressed in OSCC, whereas TGIF1v5 is underexpressed when compared with NT. Low TGIF1v8 expression was correlated with lower cellular differentiation, positive blood vascular invasion, advanced pathologic stage, and positive vascular lymphatic invasion of OSCC. TGIF1v8 is also related to overall survival over time, with lower values associated with an increased risk of cancer-related death. Conclusions: These data suggest that alternative splicing of TGIF1 is deregulated in OSCC, with overexpression of some splicing variants, especially TGIF1v8, which is associated with advanced stages of OSCC. [Copyright &y& Elsevier]

Objective: Oral non-Hodgkin lymphomas (NHLs) are an extensive group of malignant lymphoid cell neoplasms that are the second most common group of oral cancers. Subtyping NHL is important to plan for appropriate treatment, and the analysis of clonality is in many instances used for helping in the diagnosis of NHL. Thus, the aim of this study was to analyze immunoglobulin heavy chain (IgH) gene rearrangement in a series of oral B cell lymphomas to investigate the sensitivity of seminested polymerase chain reaction (snPCR). Study Design: Paraffin embedded tissue samples from 16 cases of oral B cell lymphomas were retrieved and subjected to snPCR to investigate the IgH gene rearrangement. Results: The results showed monoclonal IgH rearrangement in 85.7% of the cases studied, as represented by finding one band within the expected range of amplification. Conclusions: This study found that snPCR is a consistent method for the detection of gene rearrangement in paraffin-embedded tissue. [Copyright &y& Elsevier]

This study analyzed the efficiency of lambari Deuterodon iguape as a live bait compared to the artificial bait traditionally used in sea bass fishing (Centropomus parallelus) to demonstrate the viability of its use in recreational fishing. Two boats, with one fisherman each, operated on the Itanhaém river, on the southeastern coast of Brazil, in monthly samples, between October 2019 and September 2020. For statistical analysis, 2x2 and nx2 contingency tables were built and subsequent analysis was performed of the proportions between factors by applying Pearson's chi-squared independence test. It was found that the type of bait used was not associated with catches. In relation to the specimens of sea bass captured, their lengths varied between 20 and 50 cm and the weighed between 400 and 1500 g. The lambari D. iguape is as efficient as artificial bait for bass fishing in inland waters as one economic alternative for sports fisheries. In the context of coastal management, this study shows that the use of live bait of native species produced in a closed recirculation system is a desirable activity from a social and economic point of view, as artisanal fishermen and small rural producers can become suppliers of live baits, contributing to the generation of employment and income. • We analyzed the efficiency of lambari as a live bait to demonstrate the viability of its use in recreational fishing. • This is the first peer-reviewed publication assessing the efficiency of fishing between live bait and artificial bait. • Lambari fish is much sought after as live bait for sportfishing, being the most significant market for its cultivation in Brazil. •Artisanal fishermen and small rural producers (Barbieri et al., 2016) can become suppliers of live baits through aquaculture. [ABSTRACT FROM AUTHOR]

Objective: Clinically validated biomarkers for neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis (SWN) have not been identified to date. The biomarker working group’s goals are to (1) define biomarker needs in NF1, NF2, and SWN; (2) summarize existing data on biomarkers in NF1, NF2, and SWN; (3) outline recommendations for sample collection and biomarker development; and (4) standardize sample collection and methodology protocols where possible to promote comparison between studies by publishing standard operating procedures (SOPs). Methods: The biomarker group reviewed published data on biomarkers in NF1, NF2, and SWN and on biobanking efforts outside these diseases via literature search, defined the need for biomarkers in NF, and developed recommendations in a series of consensus meetings. Results: We describe existing biomarkers in NF and report consensus recommendations for SOP and a minimal clinical dataset to accompany samples derived from patients with NF1, NF2, and SWN in decentralized biobanks. Conclusions: These recommendations are intended to provide clinicians and researchers with a common set of guidelines to collect and store biospecimens and for establishment of biobanks for NF1, NF2, and SWN.

The article focuses on the creative process of the urban-mobile intervention (2009- 2010) of the Brazilian artists Fabio FON and Soraya Braz. The artwork emerges from reflections on the social implications of mobile technology - mainly the dissolution of tacit agreements of coexistence in urban areas. It also displays a history of experimentations that re-signify the very concept of the artwork at different times. [ABSTRACT FROM AUTHOR]

The article focuses on the creative process of the urban-mobile intervention (2009- 2010) of the Brazilian artists Fabio FON and Soraya Braz. The artwork emerges from reflections on the social implications of mobile technology - mainly the dissolution of tacit agreements of coexistence in urban areas. It also displays a history of experimentations that re-signify the very concept of the artwork at different times. [ABSTRACT FROM AUTHOR]

Background: The purpose of the present study is to verify a possible association between herpesviruses and periodontal pathogens in individuals with human immunodeficiency virus (HIV) and periodontitis. Methods: Twenty-seven patients with HIV and chronic periodontitis and 23 patients with HIV and gingivitis were included in the study. Probing depth, clinical attachment loss, gingival index, and plaque index were recorded. Blood, saliva, and subgingival plaque were processed for viral and bacterial identification. Bacteria were identified by 16S rRNA-based polymerase chain reaction and viruses by the nested polymerase chain reaction. Results: For the chronic periodontitis group, Epstein-Barr (EBV)- 1 (70.4%) and Tannerella forsythia (Tf) (51.8%) presented higher detection in subgingival plaque and saliva (81.5% and 40.7%, respectively) than in blood (22% and 0%, respectively) (P<0.005 and P<0.0001, respectively). Porphyromonas gingivalis (Pg) was more frequent in subgingival plaque (77.7%; P<0.0001). In the gingivitis group, Pg and human cytomega- lovirus (HCMV) presented higher frequency in subgingival plaque (95.6% and 91.3%, respectively; P <0.0001 and P= 0.004). Tf and EBV-1 were detected more frequently in subgingival plaque (47.8% and 78.3%, respectively) and saliva (52.2% and 52.2%, respectively; P = 0.004 and P <0.005) than in blood. EBV- 1, EBV- 1-HCMV, and presence of different viruses presented an association with periodontitis in saliva. Conclusions: No association was detected for herpesviruses and periodontal pathogens in patients who are HIV-positive with periodontitis. EBV- 1 and coinfection (EBV- 1-HCMV) were associated with patients who are HIV-positive with periodontitis. [ABSTRACT FROM AUTHOR]

Objective: TGIF1 homeobox gene involvement in oral cancer has not yet been investigated. This study analyzed the expression of TGIF1 transcripts and protein in oral squamous cell carcinoma (OSCC). Study design: Snap-frozen samples from 16 patients were taken from both OSCC and nontumoral adjacent epithelium (NT) for in situ hybridization (ISH). Forty-six paraffin-embedded samples of OSCC were submitted to immunohistochemistry (IHC). A descriptive analysis of the transcript signal detection was accomplished, and TGIF1 immunoexpression was carried out considering protein levels, localization, and cellular differentiation. Results: ISH reactions showed TGIF1 transcripts with a signal that was frequently intense in NT, and generally weak in OSCC, and that had stronger transcript signal in well-differentiated areas of OSCC when compared with poorly differentiated ones. IHC reactions had poorly differentiated cases associated with TGIF1 protein expression in both the nucleus and cytoplasm (P = .05, Fisher test). Conclusions: TGIF1 gain or loss of function might possibly play a role in oral cancer cell differentiation. [ABSTRACT FROM AUTHOR]

Glandular Odontogenic Cyst (GOC) is a rare developmental cyst of the jaws. The histological features of GOC strongly suggest an origin from the remains of dental lamina. Radiographically, GOC presents as well-defined radiolucencies with uni- or multilocular appearance. A case of GOC in a 54-year-old black female is presented here. Clinical, histological and imaging features were evaluated. Due to the high tendency of recurrence and the aggressive potential of GOC, careful clinical and radiological evaluation must be carried out. CT scans are recommended because they provide accurate information about locularity of the lesion, cortical integrity, expansion of the lesion and involvement of the contiguous soft tissue. [ABSTRACT FROM AUTHOR]

Copyright of Revista Odonto Ciencia is the property of EDIPUCRS - Editora Universitaria da PUCRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Herpesviruses may be related to the etiology of aggressive periodontitis (AgP) and chronic periodontitis (CP) by triggering periodontal destruction or by increasing the risk for bacterial infection. This case-control study evaluated the presence of herpes simplex virus type I (HSV-1), Epstein-Barr virus type I (EBV-1), human cytomegalovirus (HCMV), Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, Prevotella intermedia, and Tannerella forsythia (previously T. forsythensis) in patients with generalized AgP (AgP group), CP (CP group), or gingivitis (G group) and in healthy individuals (C group). Methods: Subgingival plaque samples were collected with paper points from 30 patients in each group. The nested polymerase chain reaction (PCR) method was used to detect HSV-1, EBV-1, and HCMV. Bacteria were identified by 16S rRNA-based PCR. Results: HSV-1, HCMV, and EBV-1 were detected in 86.7%, 46.7%, and 33.3% of the AgP group, respectively; in 40.0%, 50.0%, and 46.7% of the CP group, respectively; in 53.3%, 40.0%, and 20.0% of the G group, respectively; and in 20.0%, 56.7%, and 0.0% of the C group, respectively. A. actinomycetemcomitans was detected significantly more often in the AgP group compared to the other groups (P<0.005). P. gingivalis and T. forsythia were identified more frequently in AgP and CP groups, and AgP, CP, and G groups had higher frequencies of P. intermedia compared to the C group. Conclusion: in Brazilian patients, HSV-1 and EBV-1, rather than HCMV, were more frequently associated with CP and AgP. [ABSTRACT FROM AUTHOR]

Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis, and low survival. We report a case of CCOC affecting the mandible of a 39-year-old man. The tumor presented a biphasic pattern composed of clear cell nests intermingled with eosinophilic cells and separated by collagenous stroma. Immunoreactivity to cytokeratin (CK), specifically AE1/AE3 and CK 8, 14, 18, and 19 was found, as well as to epithelial membrane antigen (EMA). The tumor cells were negative for S100 protein, CK 13, vimentin, smooth muscle actin, laminin and type IV collagen. Low labeling indices for the proliferation markers Ki-67 and proliferating cell nuclear antigen and to p53 protein might predict a favorable prognosis for the lesion. A surgical resection was performed, followed by adjuvant radiotherapy. A 2-year follow-up has shown no signs of recurrence. The significance of histochemical and immunohistochemical resources in the correct diagnosis of CCOC is analyzed. [Copyright &y& Elsevier]

Copyright of Implant Dentistry is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Meningiomas may occur either as familial tumors in two distinct disorders, familial multiple meningioma and neurofibromatosis 2 (NF2), or sporadically, as either single or multiple tumors in individuals with no family history. Meningiomas in NF2 and approximately 60% of sporadic meningiomas involve inactivation of the NF2 locus, encoding the tumor suppressor merlin on chromosome 22q. This study was undertaken to establish whether genomic profiling could distinguish familial multiple meningiomas from sporadic solitary and sporadic multiple meningiomas. Methods: We compared 73 meningiomas presenting as sporadic solitary (64), sporadic multiple (5) and familial multiple (4) tumors using genomic profiling by array comparative genomic hybridization (array CGH). Results: Sporadic solitary meningiomas revealed genomic rearrangements consistent with at least two mechanisms of tumor initiation, as unsupervised cluster analysis readily distinguished tumors with chromosome 22 deletion (associated with loss of the NF2 tumor suppressor) from those without chromosome 22 deletion. Whereas sporadic meningiomas without chromosome 22 loss exhibited fewer chromosomal imbalance events overall, tumors with chromosome 22 deletion further clustered into two major groups that largely, though not perfectly, matched with their benign (WHO Grade I) or advanced (WHO Grades II and III) histological grade, with the latter exhibiting a significantly greater degree of genomic imbalance (P < 0.001). Sporadic multiple meningiomas showed a frequency of genomic imbalance events comparable to the atypical grade solitary tumors. By contrast, familial multiple meningiomas displayed no imbalances, supporting a distinct mechanism for the origin for these tumors. Conclusion: Genomic profiling can provide an unbiased adjunct to traditional meningioma classification and provides a basis for exploring the different genetic underpinnings of tumor initiation and progression. Most importantly, the striking difference observed between sporadic and familial multiple meningiomas indicates that genomic profiling can provide valuable information for differential diagnosis of subjects with multiple meningiomas and for considering the risk for tumor occurrence in their family members.

Synovial chondromatosis is a rare, benign cartilaginous metaplasia that affects the joints, is uncommon in the temporomandibular joint (TMJ), and is difficult to diagnose because of its generally vague symptoms. In the present report we emphasize the importance of the correct diagnosis in a noncommon location. A male patient reported recurrent episodes of dislocation and pain in the left TMJ. In the clinical examination an oral opening limitation was observed, and tomographic sections showed hyperdense, circumscribed, well-defined area in the joint space, measuring approximately 2 mm. It was surgically removed, and the histologic slices revealed a hypocellular hyaline cartilage fragment whose gaps were filled by nonatypical chondrocytes. Therefore, the histopathologic study is essential to differentiate it from a chondrosarcoma. The patient is under follow-up and is without recurrences. [ABSTRACT FROM AUTHOR]

Abstract: Objective: The aim of this study was to detect the chromosomal translocation t(12;16)(q13;p11) that leads to a gene fusion encoding a FUS-CHOP chimeric protein and has been shown to be highly characteristic of myxoid and round cell subtypes of liposarcoma, in a case of oral myxoid liposarcoma. Method and Materials: Nested reverse transcriptase–polymerase chain reaction to detect the TLS/FUS-CHOP fusion gene transcript was performed. A case of inflammatory fibrous hyperplasia and a case of oral lipoma were included as negative controls. Results: Only the myxoid oral liposarcoma showed a 103–base pair product, specific of TLS/FUS-CHOP fusion type II transcript. Conclusion: The identification of FUS-CHOP transcript is potentially useful in the diagnosis and research of oral liposarcomas. [Copyright &y& Elsevier]

Background: Baricitinib, an oral selective inhibitor of Janus kinase 1 and Janus kinase 2, modulates proinflammatory cytokine signaling.Objectives: The efficacy and safety of baricitinib were evaluated in patients with moderate-to-severe atopic dermatitis (AD).Methods: In this phase 2, randomized, double-blind, placebo-controlled study, 124 patients with moderate-to-severe AD applied topical corticosteroids (TCSs) for 4 weeks before randomization to once-daily placebo, 2 mg of baricitinib, or 4 mg of baricitinib for 16 weeks. Use of TCSs was permitted during the study. The primary outcome was the proportion of patients achieving at least a 50% reduction in the Eczema Area and Severity Index (EASI-50) compared with placebo.Results: Significantly more patients who received baricitinib, 4 mg, achieved EASI-50 than did patients receiving placebo (61% vs 37% [P = .027]) at 16 weeks. The difference between the proportion of patients receiving baricitinib, 2 or 4 mg, who achieved EASI-50 and the proportion of patients receiving placebo and achieving EASI-50 was significant as early as week 4. Baricitinib also improved pruritus and sleep loss. Treatment-emergent adverse events were reported in 24 of the patients receiving placebo (49%), 17 of those receiving 2 mg of baricitinib (46%), and 27 of those receiving 4 mg of baricitinib (71%).Limitations: A TCS standardization period before randomization reduced disease severity, limiting the ability to compare results with those of baricitinib monotherapy. Longer studies are required to confirm baricitinib's efficacy and safety in patients with AD.Conclusions: Baricitinib used with TCSs reduced inflammation and pruritus in patients with moderate-to-severe AD. [ABSTRACT FROM AUTHOR]