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1,001 results on '"Ogawa, Michio"'

61. Impairment of Kit-dependent development of interstitial cells alters contractile responses of murine intestinal tract

Author

Sato, Daisuke, Lai, Zhong-Fang, Tokutomi, Naofumi, Tokutomi, Yoshiko, Maeda, Hitomi, Nishikawa, Satomi, Nishikawa, Shin-Ichi, Ogawa, Michio, and Nishi, Katsuhide

Subjects
Gastrointestinal system -- Physiological aspects, Intestine, Small -- Physiological aspects, Rats -- Physiological aspects, Gastrointestinal system -- Motility, Biological sciences
Abstract

The effect of a rat anti-murine-Kit monoclonal body (ACK2)-induced impairment of the interstitial cell (IC) network on the contractile responses of the ileum was investigated. Electrophysiological experiments revealed that an impaired Kit-dependent IC network alters the contractile responses of the intestinal tract to pharmacological agents. It was suggested that the monoclonal antibodies impaired the Kit signaling pathway that is essential to the development of IC as pacemaker cells.

Published
1996

64. Abstracts of selected papers presented at the 32nd Annual Meeting of the Japanese Society of Gastroenterology

Author

Sata, Naohiro, Atomi, Yutaka, Ohshio, Gakuji, Manabe, Tadao, Watanabe, Shin-ichiro, Takeuchi, Tadashi, Miyasaka, Kyoko, Funakoshi, Akihiro, Hayakawa, Tetsuo, Nagai, Kenji, Murata, Atsuo, Ogawa, Michio, Takeda, Kazunori, Matsuno, Seiki, Tomiya, Tomoaki, Fujiwara, Kenji, Nakamura, Toshio, Nakanishi, Toshio, Sasaki, Iwao, Matsuno, Seiki, Yoshino, Keiichi, Makuuchi, Hiroyasu, Sawaguchi, Yuji, Uchino, Junichi, Yokoi, Hajime, Kawarada, Yoshifumi, Komatsu, Hirokazu, Oda, Masaya, Komada, Toshiyuki, Kitami, Noriyuki, Sato, Nobuhiro, Inada, Masami, Kawata, Sumio, Koga, Michiaki, Yano, Michitami, Takano, Susumu, Omata, Masao, Yasunaga, Mitsuru, Shirasawa, Hiroyuki, Ouchi, Kiyoaki, Matsuno, Seiki, ASakura, Hitoshi, Okabe, Nobuo, Yao, Tsuneyoshi, Bamba, Tadao, Fujiyama, Yoshihide, Okawa, Kiyotaka, Harihara, Shigeyoshi, Ohkusa, Toshifumi, Sasabe, Masataka, Shoji, Yasutsugu, Utsunomiya, Joji, Hayashi, S., Furukawa, T., Matsuhashi, Nobuyuki, Sugano, Kentaro, Yamazaki, Hideo, Hiwatashi, Nobuo, Ashida, Tomofumi, Ayabe, Tokiyoshi, Takazoe, Masakazu, Inoue, Noboru, Kitano, A., Kobayashi, K., Fukuda, Yoshihiro, Tamura, Kazutami, Koyama, Hiroshi, Niwa, Hirohumi, Takahashi, Shuji, Yoshikawa, Toshikazu, Mizuno, Shiuichi, Sasaki, Ei, Toyonaga, Atsushi, Okabayashi, Yoshinori, Otsuki, Makoto, Shiratori, Keiko, Watanabe, Shin-ichiro, Ozawa, Susumu, Tanaka, Shigeki, Funakoshi, Akihiro, Wakasugi, Hideyuki, Tazawa, Yusaku, Takikawa, Hajime, Kawasaki, Hironaka, Tanaka, Naomi, Kajiyama, Goro, Shimoyama, Takashi, and Kanazawa, Kyotaro

Published
1992
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73. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface: impact on human pancreatic carcinoma cell growth by autocrine regulation

Author

Hidaka, Hideki, Ishiko, Takatoshi, Furuhashi, Takashi, Kamohara, Hidenobu, Suzuki, Shunji, Miyazaki, Masashi, Ikeda, Osamu, Mita, Seiji, Setoguchi, Toshiaki, and Ogawa, Michio

Subjects
Interleukin-8 -- Physiological aspects, Cancer cells -- Physiological aspects, Pancreatic cancer -- Physiological aspects, Autocrine mechanisms -- Research, Health
Published
2002

100. Characterization of cancer cell dissociation factor in a highly invasive pancreatic cancer cell line

Author

Kurizaki, Takashi, Egami, Hiroshi, Hirota, Masahiko, Akagi, Junji, Ohmachi, Hideki, Yamamoto, Shin-ichi, and Ogawa, Michio

Subjects
Pancreatic cancer -- Physiological aspects, Cancer invasiveness -- Physiological aspects, Health
Abstract

Background. Two pancreatic cancer cell lines, the highly invasive and metastatic cell line PC-1.0 and the weakly invasive and rarely metastatic cell line PC-1, were established from a pancreatic ductal carcinoma induced by N-nitrosobis (2-oxopropyl) amine in a Syrian golden hamster. Methods. The cancer cell dissociation activity in serum-free conditioned medium of PC-1.0 cells was partially purified using a heparin column, a hydroxylapatite column, anion exchange, and gel filtration high-performance liquid chromatography. Several biologic properties of the partially purified activity were evaluated. Results. Two cell lines exhibited different growth morphologic changes in vitro: the weakly invasive cell line PC-1 formed islandlike colonies, and the highly invasive cell line PC-1.0 grew mainly as single cells. The conditioned medium of PC-1.0 cells induced dissociation of islandlike colonies and morphologic changes of PC-1 cells to elongated cells, with a high frequency of pseudopodia formation similar to the morphologic findings of PC-1.0 cells. The dissociation activity did not bind to the heparin column and had an apparent molecular mass of >400 kDa, as deduced from gel filtration. Several immunoreactive proteinous bands were observed in immunoblotting analysis using a polyclonal blocking antibody. The partially purified activity enhanced cell motility, chemoinvasion, and cell adhesion to plastic plates and fibronectin. Conclusions. Highly invasive and metastatic PC-1.0 cells produce a soluble proteinous factor, called 'dissociation factor' (DF), which induces cell dissociation of weakly invasive and rarely metastatic PC-1 cells. It seems likely that DF has a role in tumor invasion and metastasis. Cancer 1995; 75:1554-61.

Published
1995

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