508 results on '"Olszewski, Pawel"'
Search Results
52. Preliminary Exploration of Obesity-Related Eating Behaviour Patterns in a Sample of Saudi Preschoolers Aged 2–6 Years through the Children’s Eating Behaviour Questionnaire
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Al-Hamad, Ali H., primary, Al-Naseeb, Aljohara M., additional, Al-Assaf, Maha S., additional, Al-Obaid, Suzan A., additional, Al-Abdulkarim, Bandar S., additional, and Olszewski, Pawel K., additional
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- 2021
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53. High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing.
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Kostecka, Anna, primary, Nowikiewicz, Tomasz, additional, Olszewski, Pawel, additional, Koczkowska, Magdalena, additional, Horbacz, Monika, additional, Heinzl, Monika, additional, Andreou, Maria, additional, Salazar, Renato, additional, Mair, Theresa, additional, Madanecki, Piotr, additional, Gucwa, Magdalena, additional, Davies, Hanna, additional, Skokowski, Jaroslaw, additional, Buckley, Patrick G., additional, Peksa, Rafal, additional, Srutek, Ewa, additional, Szylberg, Lukasz, additional, Hartman, Johan, additional, Jankowski, Michal, additional, Zegarski, Wojciech, additional, Tiemann-Boege, Irene, additional, Dumanski, Jan P., additional, and Piotrowski, Arkadiusz, additional
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- 2021
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54. Effect of combination of peripheral oxytocin and naltrexone at subthreshold doses on food intake, body weight and feeding-related brain gene expression in male rats
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Head, Mitchell A., primary, Levine, Allen S., additional, Christian, David G., additional, Klockars, Anica, additional, and Olszewski, Pawel K., additional
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- 2021
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55. Random Deep Neural Network for Melanoma Recognition
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Swiderski, Bartosz, primary, Osowski, Stanislaw, additional, Olszewski, Pawel, additional, Gielata, Lukasz, additional, Slowinska, Monika, additional, and Lugowska, Iwona, additional
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- 2021
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56. Goat’s vs cow’s milk consumption: Analysis of feeding behaviour, brain activation and gene expression in laboratory animals
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Olszewski, Pawel K., Klockars, Anica, Prosser, Colin G., Olszewski, Pawel K., Klockars, Anica, and Prosser, Colin G.
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Milk is a complex and highly nutritive food. In Western societies, cow’s milk (CM) is most commonly consumed, but recent years have generated interest in milk from other species, especially in goat’s milk (GM). Importantly, select physical and chemical properties of milk are species-dependent and – thus – so are the physiological consequences of consumption of milk sourced from specific species. For example, variation between GM and CM protein impacts digestibility and gastrointestinal processes. Consumption of GM vs CM differentially affects levels of blood hormones regulating energy balance. Furthermore, some conflicting results on acceptability of GM- and CM-based foods have been reported, and it is unclear to what extent habituation to a specific milk type underpins these parameters. To add to the confusion, CM and GM are typically consumed and, therefore, studied as modified milk products, with one of the typical compositional alterations being done to the protein fraction in which the natural 20:80 whey:casein ratio is changed to resemble the 60:40 ratio of human milk. One of the most fundamental gaps in our knowledge regarding CM vs GM relates to the acceptability, palatability and satiating properties of these milks and to appetite-controlling brain processes triggered by CM and GM consumption. Thus, in this doctoral project, I sought to examine whether GM and CM diets elicit unique feeding responses in laboratory rodents and whether the presumed appetite differences are associated with changes in neuronal activation and/or gene expression in key central regions regulating food intake. In Specific Aim 1 of the project, I conducted a comprehensive investigation of short-term intake and palatability profiles of GM- and CM-based liquid and solid diets in mice and rats. Consumption was studied in no-choice and choice scenarios, including meal microstructure. Feeding experiments were followed by qPCR analysis of expression of relevant genes in the energy balance
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- 2021
57. Oxytocin as a pharmacological tool to curb overeating: Exploring synergy with opioid receptor blockade
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Olszewski, Pawel K. and Olszewski, Pawel K.
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The key factors shaping consumption involve a feeling of hunger (determines search for calories), satiation (underpins termination of ingestive behaviour), and reward (adjusts consumption to the 'pleasantness' of food, regardless of actual energy needs). Though each of the many feeding-related neural systems affects the select facets of appetite to a different degree, most basic research (and subsequently, also clinical) studies exploring anorexigenic potential of neuroactive molecules, focus on targeting only one system. This single-system approach has been the case for one of the most potent anorexigens identified to-date, oxytocin (OT). OT is known to promote satiation and its release coincides with, e.g., excessive stomach distension and osmolality. OT’s effects on feeding reward are weaker as they are mitigated by macronutrient composition, flavour and energy density. Its potential influence on perceived hunger is unknown. Therefore, in this thesis I wished to examine whether by combining OT with a ligand that targets those facet(s) of feeding largely unaffected by OT, a synergistic effect on feeding can be achieved. Considering that opioid receptor antagonists mainly reduce reward-driven feeding, but do not promote satiety (notably, their effect on hunger remains undefined), I focused on investigating the simultaneous effects of OT receptor stimulation and opioid receptor blockade on food intake. As the potential impact of either opioid antagonists or OT alone on hunger perception has never been examined, prior to studying simultaneous effects of the two types of molecules on feeding, I investigated whether either OT or opioid ligands individually reduce a feeling of hunger. The first set of experiments explored whether hypophagic doses of OT would alter hunger responsiveness in male rats trained to discriminate between 22 h (hunger) vs 2 h (no hunger) food deprivation in a two-lever, operant discrimination procedure. Intraperitoneal (i.p.) OT did not decrease
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- 2021
58. Variable degree of mosaicism for tetrasomy 18p in phenotypically discordant monozygotic twins-Diagnostic implications
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Rydzanicz, Malgorzata, Olszewski, Pawel, Kedra, Darek, Davies, Hanna, Filipowicz, Natalia, Bruhn-Olszewska, Bozena, Cavalli, Marco, Szczaluba, Krzysztof, Mlynek, Marlena, Machnicki, Marcin M., Stawinski, Piotr, Kostrzewa, Grazyna, Krajewski, Pawel, Sladowski, Dariusz, Chrzanowska, Krystyna, Dumanski, Jan P., Ploski, Rafal, Rydzanicz, Malgorzata, Olszewski, Pawel, Kedra, Darek, Davies, Hanna, Filipowicz, Natalia, Bruhn-Olszewska, Bozena, Cavalli, Marco, Szczaluba, Krzysztof, Mlynek, Marlena, Machnicki, Marcin M., Stawinski, Piotr, Kostrzewa, Grazyna, Krajewski, Pawel, Sladowski, Dariusz, Chrzanowska, Krystyna, Dumanski, Jan P., and Ploski, Rafal
- Abstract
Background: Phenotypically discordant monozygotic twins (PDMZTs) offer a unique opportunity to study post-zygotic genetic variation and provide insights into the linkage between genotype and phenotype. We report a comprehensive analysis of a pair of PDMZTs. Methods: Dysmorphic features and delayed neuro-motor development were observed in the proband, whereas her twin sister was phenotypically normal. Four tissues (blood, skin, hair follicles, and buccal mucosa) from both twins were studied using four complementary methods, including whole-exome sequencing, karyotyping, array CGH, and SNP array. Results: In the proband, tetrasomy 18p affecting all studied tissues except for blood was identified. Karyotyping of fibroblasts revealed isochromosome 18p [i(18p)] in all metaphases. The corresponding analysis of the phenotypically normal sister surprisingly revealed low-level mosaicism (5.4%) for i(18p) in fibroblasts. Conclusion: We emphasize that when mosaicism is suspected, multiple tissues should be studied and we highlight the usefulness of non-invasive sampling of hair follicles and buccal mucosa as a convenient source of non-mesoderm-derived DNA, which complements the analysis of mesoderm using blood. Moreover, low-level mosaic tetrasomy 18p is well tolerated and such low-level mosaicism, readily detected by karyotyping, can be missed by other methods. Finally, mosaicism for low-level tetrasomy 18p might be more common in the general population than it is currently recognized, due to detection limitations.
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- 2021
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59. Analysis of the network of feeding neuroregulators using the Allen Brain Atlas
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Olszewski, Pawel K., Cedernaes, Jonathan, Olsson, Fredrik, Levine, Allen S., and Schiöth, Helgi B.
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- 2008
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60. Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness
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Olszewski, Pawel K., Grace, Martha K., Fard, Shahrzad Shirazi, Le Greves, Madeleine, Klockars, Anica, Massi, Maurizio, Schioth, Helgi B., and Levine, Allen S.
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Amygdala (Brain) -- Physiological aspects ,Amygdala (Brain) -- Research ,Bioenergetics -- Physiological aspects ,Bioenergetics -- Research ,Energy metabolism -- Physiological aspects ,Energy metabolism -- Research ,Nociceptors -- Physiological aspects ,Nociceptors -- Research ,Polymerase chain reaction -- Usage ,Biological sciences - Abstract
Nociceptin/orphanin FQ (N/OFQ), the nociceptin opioid peptide (NOP) receptor ligand, increases feeding when injected centrally. Initial data suggest that N/OFQ blocks the development of a conditioned taste aversion (CTA). The current project further characterized the involvement of N/OFQ in the regulation of hunger vs. aversive responses in rats by employing behavioral, immunohistochemical, and real-time PCR methodology. We determined that the same low dose of the NOP antagonist [[Nphe.sup.1]]N/OFQ(1-13)[NH.sub.2] delivered via the lateral ventricle diminishes both N/OFQ-and deprivation-induced feeding. This anorexigenic effect did not stem from aversive consequences, as the antagonist did not cause the development of a CTA. When [[Nphe.sup.1]]N/OFQ(1-13)[NH.sub.2] was administered with LiC1, it moderately delayed extinction of the LiC1-induced CTA. Injection of LiC1 + antagonist compared with LiC1 alone generated an increase in c-Fos immunoreactivity in the central nucleus of the amygdala. The antagonist alone elevated Fos immunoreactivity in the paraventricular nucleus of the hypothalamus, nucleus of the solitary tract, and central nucleus of the amygdala. Hypothalamic NOP mRNA levels were decreased during energy intake restriction induced by aversion, as well as in non-CTA rats food-restricted to match CTA-reduced consumption. Brain stem NOP was upregulated only in aversion. Prepro-N/OFQ mRNA showed a trend toward upregulation in restricted rats (P = 0.068). We conclude that the N/OFQ system promotes feeding by affecting the need to replenish lacking calories and by reducing aversive responsiveness. It may belong to mechanisms that shift a balance between the drive to ingest energy and avoidance of potentially tainted food. food intake; conditioning; hypothalamus; brain stem; amygdala; lithium chloride; NOP receptor; ORLI doi: 10.1152/ajpregu.00556.2009.
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- 2010
61. A non-peptide oxytocin receptor agonist, WAY-267,464, alleviates novelty-induced hypophagia in mice: Insights into changes in c-Fos immunoreactivity
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Olszewski, Pawel K., Ulrich, Christine, Ling, Nicholas, Allen, Kerry, and Levine, Allen S.
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- 2014
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62. Adjustment of Whey:Casein Ratio from 20:80 to 60:40 in Milk Formulation Affects Food Intake and Brainstem and Hypothalamic Neuronal Activation and Gene Expression in Laboratory Mice
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Wood, Erin L., primary, Christian, David G., additional, Arafat, Mohammed, additional, McColl, Laura K., additional, Prosser, Colin G., additional, Carpenter, Elizabeth A., additional, Levine, Allen S., additional, Klockars, Anica, additional, and Olszewski, Pawel K., additional
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- 2021
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63. Impact of Gut and Metabolic Hormones on Feeding Reward
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Klockars, Anica, primary, Levine, Allen S., additional, Head, Mitchell A., additional, Perez‐Leighton, Claudio E., additional, Kotz, Catherine M., additional, and Olszewski, Pawel K., additional
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- 2021
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64. Variable degree of mosaicism for tetrasomy 18p in phenotypically discordant monozygotic twins—Diagnostic implications
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Rydzanicz, Małgorzata, primary, Olszewski, Pawel, additional, Kedra, Darek, additional, Davies, Hanna, additional, Filipowicz, Natalia, additional, Bruhn‐Olszewska, Bozena, additional, Cavalli, Marco, additional, Szczałuba, Krzysztof, additional, Młynek, Marlena, additional, Machnicki, Marcin M., additional, Stawiński, Piotr, additional, Kostrzewa, Grażyna, additional, Krajewski, Paweł, additional, Śladowski, Dariusz, additional, Chrzanowska, Krystyna, additional, Dumanski, Jan P., additional, and Płoski, Rafał, additional
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- 2020
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65. Effect of peptide histidine isoleucine on consummatory behavior in rats
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Olszewski, Pawel K., Wirth, Michelle M., Shaw, Timothy J., Grace, Martha K., and Levine, Allen S.
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Human physiology -- Research ,Histidine -- Physiological aspects ,Biological sciences - Abstract
Peptide histidine isoleucine (PHI) and VIP are derived from the same precursor. While central VIP decreases food intake, potential effects of PHI on feeding have not been studied. In the current study, we found that PHI administered intracerebroventricularly (ICV) or into the hypothalamic paraventricular nucleus (PVN) or central nucleus of the amygdala (CeA) decreased food consumption in overnight-deprived rats. The magnitude of an anorexigenic response to PHI differed depending on the injection route: ICV-infused peptide evoked the most potent effect. We determined that that only PVN- and CeA-injected PHI did not have aversive consequences. In addition, we infused anorexigenic doses of PHI via the same routes and assessed Fos immunoreactivity of PVN oxytocin (OT) and vasopressin (VP) neurons using double immunohistochemistry. OT and VP are thought to promote feeding termination. PHI increased the percentage of Fos-positive OT neurons regardless of the injection route. PVN- and ICV-infused PHI induced activation of VP cells. We conclude that central PHI has an inhibitory influence on food intake in rats. The PVN, with OT and VP neurons, and CeA may be involved in the mediation of anorexigenic effects of PHI. conditioned taste aversion; oxytocin; vasopressin; paraventricular nucleus of the hypothalamus; amygdala
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- 2003
66. List of Contributors
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Abizaid, Alfonso, primary, Alsiö, Johan, additional, Andersen, Ross, additional, Anisman, Hymie, additional, Arora, Narendra K., additional, Augustin, Livia S.A., additional, Bakovic, Marica, additional, Bell, Ruth, additional, Beauchamp, Gary K., additional, Beauvais, Janet, additional, Bechara, Antoine, additional, Bernstein, William, additional, Bhattacharjee, Lalita, additional, Blundell, John, additional, Brand-Miller, Jennie, additional, Bryant, Eleanor, additional, Caballero, Benjamin, additional, Carman, Katherine G., additional, Carr, Kenneth D., additional, Chaput, Jean-Philippe, additional, Chen, Xiaoye, additional, Chiavaroli, Laura, additional, Colagiuri, Stephen, additional, Dagher, Alain, additional, Das, Manoja Kumar, additional, de Castro, John M., additional, Del Parigi, Angelo, additional, Deschambault, Branden R., additional, Dickinson, Scott, additional, Ditschun, Tanya L., additional, Drewnowski, Adam, additional, Dubé, Laurette, additional, Eichelsdoerfer, Petra, additional, El-Sohemy, Ahmed, additional, Eny, Karen M., additional, Essex, Brian G., additional, Evans, Gary W., additional, Finlayson, Graham, additional, Fishbach, Ayelet, additional, Fisher, Robert J., additional, Fresco, Louise, additional, Gorin, Amy A., additional, Halford, Jason, additional, Hammond, Ross A., additional, Hawkes, Corinna, additional, Herman, C. Peter, additional, Irvine, William B., additional, James, Philip, additional, Jenkins, David J.A., additional, Johnson, Philip J., additional, Jones, Peter J.H., additional, Josse, Andrea R., additional, Kahneman, Daniel, additional, Kendall, Cyril W.C., additional, Killgore, William D.S., additional, King, Neil, additional, Knäuper, Bärbel, additional, Kooreman, Peter, additional, Kumanyika, Shiriki, additional, Larson, Nicole, additional, Lawton, Clare, additional, Leahy, Kathleen E., additional, LeBel, Jordan, additional, Galès, Catherine Le, additional, Levine, Allen S., additional, Li, Shanling, additional, Logue, Alexandra. W., additional, MacKay, Dylan, additional, Marmot, Michael, additional, Mathers, John C., additional, Medina, John J., additional, Mennella, Julie A., additional, Mongeau, Lyne, additional, Monteiro, Carlos A., additional, Moore, Karl J., additional, Moore, Spencer, additional, Moskowitz, Howard R., additional, Mutch, David M., additional, Myrseth, Kristian Ove R., additional, Naslund, Erik, additional, Olszewski, Pawel K., additional, Panksepp, Jaak, additional, Patrick, Heather, additional, Pingali, Prabhu, additional, Pliner, Patricia P., additional, Polivy, Janet, additional, Reisner, Michele, additional, Renaud, Lise, additional, Richard, Denis, additional, Robinson, Thomas N., additional, Rolls, Barbara J., additional, Rolls, Edmund T., additional, Sabiston, Catherine, additional, Salvy, Sarah-Jeanne, additional, Saxena, Nishta, additional, Schamberg, Michelle A., additional, Schiöth, Helgi B., additional, Srinivasan, T.N., additional, Stich, Christine, additional, Story, Mary, additional, Tannenbaum, Beth M., additional, Thibault, Louise, additional, Timofeeva, Elena, additional, Tontisirin, Kraisid, additional, Tremblay, Angelo, additional, van Loon, Josh, additional, Webb, Patrick, additional, Wells, Nancy M., additional, Williams, Geoffrey C., additional, Wong, Julia M.W., additional, Xiao, Lin, additional, Yeomans, Martin R, additional, Zald, David H., additional, Zhang, Dan, additional, and Zhang, Wenqing, additional
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- 2010
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67. Opioids
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Olszewski, Pawel K., primary, Alsiö, Johan, additional, Schiöth, Helgi B., additional, and Levine, Allen S., additional
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- 2010
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68. Expression levels of genes encoding melanin concentrating hormone (MCH) and MCH receptor change in taste aversion, but MCH injections do not alleviate aversive responses
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Mitra, Anaya, Klockars, Anica, Gosnell, Blake A., Le Grevès, Madeleine, Olszewski, Pawel K., Levine, Allen S., and Schiöth, Helgi B.
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- 2012
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69. Macronutrients
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Olszewski, Pawel, primary and Levine, Allen, additional
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- 2008
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70. Effects of opioid receptor ligands in rats trained to discriminate 22 from 2 hours of food deprivation suggest a lack of opioid involvement in eating for hunger
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Jewett, David C., primary, Klockars, Anica, additional, Smith, Travis R., additional, Brunton, Chloe, additional, Head, Mitchell A., additional, Tham, Rachel L., additional, Kwilasz, Andrew J., additional, Hahn, Thomas W., additional, Wiebelhaus, Jason M., additional, Ewan, Eric E., additional, Carroll, Regina M., additional, Grace, Martha K., additional, Levine, Allen S., additional, and Olszewski, Pawel K., additional
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- 2020
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71. Oxytocin as feeding inhibitor: Maintaining homeostasis in consummatory behavior
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Olszewski, Pawel K., Klockars, Anica, Schiöth, Helgi B., and Levine, Allen S.
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- 2010
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72. Molecular, Immunohistochemical, and Pharmacological Evidence of Oxytocinʼs Role as Inhibitor of Carbohydrate But Not Fat Intake
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Olszewski, Pawel K., Klockars, Anica, Olszewska, Agnieszka M., Fredriksson, Robert, Schiöth, Helgi B., and Levine, Allen S.
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- 2010
73. The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain
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Fredriksson, Robert, primary, Sreedharan, Smitha, additional, Nordenankar, Karin, additional, Alsiö, Johan, additional, Lindberg, Frida A., additional, Hutchinson, Ashley, additional, Eriksson, Anders, additional, Roshanbin, Sahar, additional, Ciuculete, Diana M., additional, Klockars, Anica, additional, Todkar, Aniruddha, additional, Hägglund, Maria G., additional, Hellsten, Sofie V., additional, Hindlycke, Viktoria, additional, Västermark, Åke, additional, Shevchenko, Ganna, additional, Olivo, Gaia, additional, K, Cheng, additional, Kullander, Klas, additional, Moazzami, Ali, additional, Bergquist, Jonas, additional, Olszewski, Pawel K., additional, and Schiöth, Helgi B., additional
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- 2019
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74. Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin
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Mitra, Anaya, Gosnell, Blake A., Schiöth, Helgi B., Grace, Martha K., Klockars, Anica, Olszewski, Pawel K., and Levine, Allen S.
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- 2010
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75. Central Regulation of Feeding
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Olszewski, Pawel, primary, Billington, Charles, additional, Levine, Allen, additional, and Kotz, Catherine, additional
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- 2005
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76. Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: Involvement of opioids, orexin, oxytocin and NPY
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Olszewski, Pawel K., Shaw, Timothy J., Grace, Martha K., Höglund, Catherine E., Fredriksson, Robert, Schiöth, Helgi B., and Levine, Allen S.
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- 2009
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77. The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain
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Fredriksson, Robert, Hägglund, Maria, Olszewski, Pawel K., Stephansson, Olga, Jacobsson, Josefin A., Olszewska, Agnieszka M., Levine, Allen S., Lindblom, Jonas, and Schiöth, Helgi B.
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- 2008
78. Genetic predisposition to mosaic Y chromosome loss in blood
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Thompson, Deborah J, Genovese, Giulio, Halvardson, Jonatan, Ulirsch, Jacob C, Wright, Daniel J, Terao, Chikashi, Davidsson, Olafur B, Day, Felix R, Sulem, Patrick, Jiang, Yunxuan, Danielsson, Marcus, Davies, Hanna, Dennis, Joe, Dunlop, Malcolm G, Easton, Douglas F, Fisher, Victoria A, Zink, Florian, Houlston, Richard S, Ingelsson, Martin, Kar, Siddhartha, Kerrison, Nicola D, Kinnersley, Ben, Kristjansson, Ragnar P, Law, Philip J, Li, Rong, Loveday, Chey, Mattisson, Jonas, McCarroll, Steven A, Murakami, Yoshinori, Murray, Anna, Olszewski, Pawel, Rychlicka-Buniowska, Edyta, Scott, Robert A, Thorsteinsdottir, Unnur, Tomlinson, Ian, Moghadam, Behrooz Torabi, Turnbull, Clare, Wareham, Nicholas J, Gudbjartsson, Daniel F, International Lung Cancer Consortium (INTEGRAL-ILCCO), Breast Cancer Association Consortium, Consortium Of Investigators Of Modifiers Of BRCA1/2, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, Prostate Cancer Association Group To Investigate Cancer Associated Alterations In The Genome (PRACTICAL) Consortium, Kidney Cancer GWAS Meta-Analysis Project, EQTLGen Consortium, Biobank-Based Integrative Omics Study (BIOS) Consortium, 23andMe Research Team, Kamatani, Yoichiro, Hoffmann, Eva R, Jackson, Steve P, Stefansson, Kari, Auton, Adam, Ong, Ken K, Machiela, Mitchell J, Loh, Po-Ru, Dumanski, Jan P, Chanock, Stephen J, Forsberg, Lars A, Perry, John RB, Thompson, Deborah [0000-0003-1465-5799], Wright, Daniel [0000-0003-3983-2093], Day, Felix [0000-0003-3789-7651], Dennis, Joe [0000-0003-4591-1214], Easton, Douglas [0000-0003-2444-3247], Wareham, Nicholas [0000-0003-1422-2993], Jackson, Stephen [0000-0001-9317-7937], Ong, Kenneth [0000-0003-4689-7530], Perry, John [0000-0001-6483-3771], and Apollo - University of Cambridge Repository
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Adult ,Genetic Markers ,Male ,0303 health sciences ,Chromosomes, Human, Y ,Mosaicism ,Computational Biology ,Middle Aged ,Genomic Instability ,United Kingdom ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Neoplasms ,Databases, Genetic ,Leukocytes ,Humans ,Female ,Genetic Predisposition to Disease ,Chromosome Deletion ,030304 developmental biology ,Aged - Abstract
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.
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- 2019
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79. Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers
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Thompson, Deborah, Genovese, Giulio, Halvardson, Jonatan, Ulirsch, Jacob, Wright, Daniel, Terao, Chikashi, Davidsson, Olafur, Day, Felix, Sulem, Patrick, Jiang, Yunxuan, Danielsson, Marcus, Davies, Hanna, Dennis, Joe, Dunlop, Malcolm, Easton, Douglas, Fisher, Victoria, Zink, Florian, Houlston, Richard, Ingelsson, Martin, Kar, Siddhartha, Kerrison, Nicola, Kristjansson, Ragnar, Li, Rong, Loveday, Chey, Mattisson, Jonas, McCarroll, Steven, Murakami, Yoshinori, Murray, Anna, Olszewski, Pawel, Rychlicka-Buniowska, Edyta, Scott, Robert, Thorsteinsdottir, Unnur, Tomlinson, Ian, Torabi Moghadam, Behrooz, Turnbull, Clare, Wareham, Nicholas, Gudbjartsson, Daniel, Kamatani, Yoichiro, Finucane, Hilary, Hoffmann, Eva, Jackson, Steve, Stefansson, Kari, Auton, Adam, Ong, Ken, Machiela, Mitchell, Loh, Po-Ru, Dumanski, Jan, Chanock, Stephen, Forsberg, Lars, and Perry, John
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0303 health sciences ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,3. Good health ,030304 developmental biology - Abstract
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism, yet our knowledge of the causes and consequences of this is limited. Using a newly developed approach, we estimate that 20% of the UK Biobank male population (N=205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes involved in cell-cycle regulation, cancer susceptibility, somatic drivers of tumour growth and cancer therapy targets. Genetic susceptibility to LOY is associated with non-haematological health outcomes in both men and women, supporting the hypothesis that clonal haematopoiesis is a biomarker of genome instability in other tissues. Single-cell RNA sequencing identifies dysregulated autosomal gene expression in leukocytes with LOY, providing insights into how LOY may confer cellular growth advantage. Collectively, these data highlight the utility of studying clonal mosaicism to uncover fundamental mechanisms underlying cancer and other ageing-related diseases.
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- 2019
80. Additional file 4: of Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain
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Jacobson, Gregory, Voss, Logan, Klockars, Anica, Bird, Steve, Dimitrov, Ivo, Denny, William, Olszewski, Pawel, Sleigh, James, and Harvey, Martyn
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sense organs ,skin and connective tissue diseases - Abstract
qPCR data. qPCR data for tested changes in gene expression. (DOCX 13 kb)
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- 2019
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81. Additional file 1: of Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain
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Jacobson, Gregory, Voss, Logan, Klockars, Anica, Bird, Steve, Dimitrov, Ivo, Denny, William, Olszewski, Pawel, Sleigh, James, and Harvey, Martyn
- Subjects
body regions ,nervous system ,fungi - Abstract
QC sequencing. Quality control and summary statistics data for RNA sequencing experiment. (PDF 181 kb)
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- 2019
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82. α-Melanocyte stimulating hormone and ghrelin: Central interaction in feeding control
- Author
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Olszewski, Pawel K., Bomberg, Eric M., Grace, Martha K., and Levine, Allen S.
- Published
- 2007
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83. Functional interaction between nociceptin/orphanin FQ and α-melanocyte-stimulating hormone in the regulation of feeding
- Author
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Bomberg, Eric M., Grace, Martha K., Levine, Allen S., and Olszewski, Pawel K.
- Published
- 2006
- Full Text
- View/download PDF
84. Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
-
Brown, Peter, Zhou, Yaoqi, Tan, Aik-Choon, El-Esawi, Mohamed A., Liehr, Thomas, Blanck, Oliver, Gladue, Douglas P., Almeida, Gabriel M.F., Cernava, Tomislav, Sorzano, Carlos O., Yeung, Andy W.K., Engel, Michael S., Chandrasekaran, Arun R., Muth, Thilo, Staege, Martin S., Daulatabad, Swapna V., Widera, Darius, Zhang, Junpeng, Meule, Adrian, Honjo, Ken, Pourret, Olivier, Yin, Cong-Cong, Zhang, Zhongheng, Cascella, Marco, Flegel, Willy A., Goodyear, Carl S., van Raaij, Mark J., Bukowy-Bieryllo, Zuzanna, Campana, Luca G., Kurniawan, Nicholas A., Lalaouna, David, Hüttner, Felix J., Ammerman, Brooke A., Ehret, Felix, Cobine, Paul A., Tan, Ene-Choo, Han, Hyemin, Xia, Wenfeng, McCrum, Christopher, Dings, Ruud P.M., Marinello, Francesco, Nilsson, Henrik, Nixon, Brett, Voskarides, Konstantinos, Yang, Long, Costa, Vincent D., Bengtsson-Palme, Johan, Bradshaw, William, Grimm, Dominik G., Kumar, Nitin, Martis, Elvis, Prieto, Daniel, Sabnis, Sandeep C., Amer, Said E.D.R., Liew, Alan W.C., Perco, Paul, Rahimi, Farid, Riva, Giuseppe, Zhang, Chongxing, Devkota, Hari P., Ogami, Koichi, Basharat, Zarrin, Fierz, Walter, Siebers, Robert, Tan, Kok H., Boehme, Karen A., Brenneisen, Peter, Brown, James A.L., Dalrymple, Brian P., Harvey, David J., Ng, Grace, Werten, Sebastiaan, Bleackley, Mark, Dai, Zhanwu, Dhariwal, Raman, Gelfer, Yael, Hartmann, Marcus D., Miotla, Pawel, Tamaian, Radu, Govender, Pragashnie, Gurney-Champion, Oliver J., Kauppila, Joonas H., Zhang, Xiaolei, Echeverría, Natalia, Subhash, Santhilal, Sallmon, Hannes, Tofani, Marco, Bae, Taeok, Bosch, Oliver, Cuív, Páraic O., Danchin, Antoine, Diouf, Barthelemy, Eerola, Tuomas, Evangelou, Evangelos, Filipp, Fabian, Klump, Hannes, Kurgan, Lukasz, Smith, Simon S., Terrier, Olivier, Tuttle, Neil, Ascher, David B., Janga, Sarath C., Schulte, Leon N., Becker, Daniel, Browngardt, Christopher, Bush, Stephen J., Gaullier, Guillaume, Ide, Kazuki, Meseko, Clement, Werner, Gijsbert D.A., Zaucha, Jan, Al-Farha, Abd A., Greenwald, Noah F., Popoola, Segun I., Rahman, Shaifur, Xu, Jialin, Yang, Sunny Y., Hiroi, Noboru, Alper, Ozgul M., Baker, Chris I., Bitzer, Michael, Chacko, George, Debrabant, Birgit, Dixon, Ray, Forano, Evelyne, Gilliham, Matthew, Kelly, Sarah, Klempnauer, Karl-Heinz, Lidbury, Brett A., Lin, Michael Z., Lynch, Iseult, Ma, Wujun, Maibach, Edward W., Mather, Diane E., Nandakumar, Kutty S., Ohgami, Robert S., Parchi, Piero, Tressoldi, Patrizio, Xue, Yu, Armitage, Charles, Barraud, Pierre, Chatzitheochari, Stella, Coelho, Luis P., Diao, Jiajie, Doxey, Andrew C., Gobet, Angélique, Hu, Pingzhao, Kaiser, Stefan, Mitchell, Kate M., Salama, Mohamed F., Shabalin, Ivan G., Song, Haijun, Stevanovic, Dejan, Yadollahpour, Ali, Zeng, Erliang, Zinke, Katharina, Alimba, C.G., Beyene, Tariku J., Cao, Zehong, Chan, Sherwin S., Gatchell, Michael, Kleppe, Andreas, Piotrowski, Marcin, Torga, Gonzalo, Woldesemayat, Adugna A., Cosacak, Mehmet I., Haston, Scott, Ross, Stephanie A., Williams, Richard, Wong, Alvin, Abramowitz, Matthew K., Effiong, Andem, Lee, Senhong, Abid, Muhammad B., Agarabi, Cyrus, Alaux, Cedric, Albrecht, Dirk R., Atkins, Gerald J., Beck, Charles R., Bonvin, A.M.J.J., Bourke, Emer, Brand, Thomas, Braun, Ralf J., Bull, James A., Cardoso, Pedro, Carter, Dee, Delahay, Robin M., Ducommun, Bernard, Duijf, Pascal H.G., Epp, Trevor, Eskelinen, Eeva-Liisa, Fallah, Mazyar, Farber, Debora B., Fernandez-Triana, Jose, Feyerabend, Frank, Florio, Tullio, Friebe, Michael, Furuta, Saori, Gabrielsen, Mads, Gruber, Jens, Grybos, Malgorzata, Han, Qian, Heinrich, Michael, Helanterä, Heikki, Huber, Michael, Jeltsch, Albert, Jiang, Fan, Josse, Claire, Jurman, Giuseppe, Kamiya, Haruyuki, de Keersmaecker, Kim, Kristiansson, Erik, de Leeuw, Frank-Erik, Li, Jiuyong, Liang, Shide, Lopez-Escamez, Jose A., Lopez-Ruiz, Francisco J., Marchbank, Kevin J., Marschalek, Rolf, Martín, Carmen S., Miele, Adriana E., Montagutelli, Xavier, Morcillo, Esteban, Nicoletti, Rosario, Niehof, Monika, O'Toole, Ronan, Ohtomo, Toshihiko, Oster, Henrik, Palma, Jose-Alberto, Paterson, Russell, Peifer, Mark, Portilla, Maribel, Portillo, M.C., Pritchard, Antonia L., Pusch, Stefan, Raghava, Gajendra P.S., Roberts, Nicola J., Ross, Kehinde, Schuele, Birgitt, Sergeant, Kjell, Shen, Jun, Stella, Alessandro, Sukocheva, Olga, Uversky, Vladimir N., Vanneste, Sven, Villet, Martin H., Viveiros, Miguel, Vorholt, Julia A., Weinstock, Christof, Yamato, Masayuki, Zabetakis, Ioannis, Zhao, Xin, Ziegler, Andreas, Aizat, Wan M., Atlas, Lauren, Bridges, Kristina M., Chakraborty, Sayan, Deschodt, Mieke, Domingues, Helena S., Esfahlani, Shabnam S., Falk, Sebastian, Guisado, J.L., Kane, Nolan C., Kueberuwa, Gray, Lau, Colleen L., Liang, Dai, Liu, Enwu, Luu, Andreas M., Ma, Chuang, Ma, Lisong, Moyer, Robert, Norris, Adam D., Panthee, Suresh, Parsons, Jerod R., Peng, Yousong, Pinto, Ines M., Reschke, Cristina R., Sillanpää, Elina, Stewart, Christopher J., Uhle, Florian, Yang, Hui, Zhou, Kai, Zhu, Shu, Ashry, Mohamed, Bergsland, Niels, Berthold, Maximilian, Chen, Chang-Er, Colella, Vito, Cuypers, Maarten, Eskew, Evan A., Fan, Xiao, Gajda, Maksymilian, Gonzálezlez-Prendes, Rayner, Goodin, Amie, Graham, Emily B., Groen, Ewout J.N., Gutiérrez-Sacristán, Alba, Habes, Mohamad, Heffler, Enrico, Higginbottom, Daniel B., Janzen, Thijs, Jayaraman, Jayakumar, Jibb, Lindsay A., Jongen, Stefan, Kinyanjui, Timothy, Koleva-Kolarova, Rositsa G., Li, Zhixiu, Liu, Yu-Peng, Lund, Bjarte A., Lussier, Alexandre A., Ma, Liping, Mier, Pablo, Moore, Matthew D., Nagler, Katja, Orme, Mark W., Pearson, James A., Prajapati, Anilkumar S., Saito, Yu, Tröder, Simon E., Uchendu, Florence, Verloh, Niklas, Voutchkova, Denitza D., Abu-Zaid, Ahmed, Bakkach, Joaira, Baumert, Philipp, Dono, Marcos, Hanson, Jack, Herbelet, Sandrine, Hobbs, Emma, Kulkarni, Ameya, Kumar, Narendra, Liu, Siqi, Loft, Nikolai D., Reddan, Tristan, Senghore, Thomas, Vindin, Howard, Xu, Haotian, Bannon, Ross, Chen, Branson, Cheung, Johnny T.K., Cooper, Jeffrey, Esnakula, Ashwini K., Feghali, Karine A., Ghelardi, Emilia, Gnasso, Agostino, Horbar, Jeffrey, Lai, Hei M., Li, Jian, Ma, Lan, Ma, Ruiyan, Pan, Zihang, Peres, Marco A., Pranata, Raymond, Seow, Esmond, Sydes, Matthew, Testoni, Ines, Westermair, Anna L., Yang, Yongliang, Afnan, Masoud, Albiol, Joan, Albuquerque, Lucia G., Amir, Shimon, Amiya, Eisuke, Amorim, Rogerio M., An, Qianli, Andersen, Stig U., Aplin, John D., Argyropoulos, Christos, Asmann, Yan W., Assaeed, Abdulaziz M., Atanasov, Atanas G., Atchison, David A., Avery, Simon V., Avillach, Paul, Baade, Peter D., Backman, Lars, Badie, Christophe, Baldi, Alfonso, Ball, Elizabeth, Bardot, Olivier, Barnett, Adrian G., Basner, Mathias, Batra, Jyotsna, Bazanova, O.M., Beale, Andrew, Beddoe, Travis, Bell, Melanie L., Berezikov, Eugene, Berners-Price, Sue, Bernhardt, Peter, Berry, Edward, Bessa, Theolis B., Billington, Craig, Birch, John, Blakely, Randy D., Blaskovich, Mark A.T., Blum, Robert, Boelaert, Marleen, Bogdanos, Dimitrios, Bosch, Carles, Bourgoin, Thierry, Bouvard, Daniel, Boykin, Laura M., Bradley, Graeme, Braun, Daniel, Brownlie, Jeremy, Brühl, Albert, Burt, Austin, Butler, Lisa M., Byrareddy, Siddappa N., Byrne, Hugh J., Cabantous, Stephanie, Calatayud, Sara, Candal, Eva, Carlson, Kimberly, Casillas, Sònia, Castelvetro, Valter, Caswell, Patrick T., Cavalli, Giacomo, Cerovsky, Vaclav, Chagoyen, Monica, Chen, Chang-Shi, Chen, Dong F., Chen, Hao, Chen, Hui, Chen, Jui-Tung, Chen, Yinglong, Cheng, Changxiu, Cheng, Jianlin, Chinapaw, Mai, Chinopoulos, Christos, Cho, William C.S., Chong, Lillian, Chowdhury, Debashish, Chwalibog, Andre, Ciresi, A., Cockcroft, Shamshad, Conesa, Ana, Cook, Penny A., Cooper, David N., Coqueret, Olivier, Corea, Enoka M., Costa, Antonio, Costa, Elisio, Coupland, Carol, Crawford, Stephanie Y., Cruz, Aparecido D., Cui, Huijuan, Cui, Qiang, Culver, David C., D'Angiulli, Amedeo, Dahms, Tanya E.S., Daigle, France, Dalgleish, Raymond, Danielsen, Håvard E., Darras, Sébastien, Davidson, Sean M., Day, David A., Degirmenci, Volkan, Demaison, Luc, Devriendt, Koenraad, Ding, Jiandong, Dogan, Yunus, Dong, X.C., Donner, Claudio F., Dressick, Walter, Drevon, Christian A., Duan, Huiling, Ducho, Christian, Dumaz, Nicolas, Dwarakanath, Bilikere S., Ebell, Mark H., Eisenhardt, Steffen, Elkum, Naser, Engel, Nadja, Erickson, Timothy B., Fairhead, Michael, Faville, Marty J., Fejzo, Marlena S., Festa, Fernanda, Feteira, Antonio, Flood-Page, Patrick, Forsayeth, John, Fox, Simon A., Franks, Steven J., Frentiu, Francesca D., Frilander, Mikko J., Fu, Xinmiao, Fujita, Satoshi, Galea, Ian, Galluzzi, Luca, Gani, Federica, Ganpule, Arvind P., García-Alix, Antonio, Gedye, Kristene, Giordano, Maurizio, Giunta, Cecilia, Gleeson, Paul A., Goarant, Cyrille, Gong, Haipeng, Gora, Diop, Gough, Michael J., Goyal, Ravinder, Graham, Kathryn E., Grande-Pérez, Ana, Graves, Patricia M., Greidanus, Harm, Grice, Darren, Grunau, Christoph, Gumulya, Yosephine, Guo, Yabin, Gurevich, Vsevolod V., Gusev, Oleg, Hacker, Elke, Hage, Steffen R., Hagen, Guy, Hahn, Steven, Haller, Dagmar M., Hammerschmidt, Sven, Han, Jianwei, Han, Renzhi, Handfield, Martin, Hapuarachchi, Hapuarachchige C., Harder, Timm, Hardingham, Jennifer E., Heck, Michelle, Heers, Marcel, Hew, Khe F., Higuchi, Yohei, Hilaire, Cynthia St., Hilton, Rachel, Hodzic, Enisa, Hone, Andrew, Hongoh, Yuichi, Hu, Guoku, Huber, Heinz P., Hueso, Luis E., Huirne, Judith, Hurt, Lisa, Idborg, Helena, Ikeo, Kazuho, Ingley, Evan, Jakeman, Philip M., Jensen, Arne, Jia, Hong, Jia, Husen, Jia, Shuqin, Jiang, Jianping, Jiang, Xingyu, Jin, Yi, Jo, Daehyun, Johnson, Andrew M., Johnston, Marie, Jonscher, Karen R., Jorens, Philippe G., Jorgensen, Jens O.L., Joubert, Johan W., Jung, Sin-Ho, Junior, Antonio M., Kahan, Thomas, Kamboj, Sunjeev K., Kang, Yong-Kook, Karamanos, Yannis, Karp, Natasha A., Kelly, Ryan, Kenna, Ralph, Kennedy, Jonathan, Kersten, Birgit, Khalaf, Roy A., Khalid, Javaria M., Khatlani, T., Khider, Tarig, Kijanka, Gregor S., King, Sarah R.B., Kluz, Tomasz, Knox, Paul, Kobayashi, Tatsuya, Koch, Karl-Wilhelm, Kohonen-Corish, Maija R.J., Kong, Xiangpeng, Konkle-Parker, Deborah, Korpela, Kalevi M., Kostrikis, Leondios G., Kraiczy, Peter, Kratz, Harald, Krause, Günter, Krebsbach, Paul H., Kristensen, Søren R., Kumari, Prerna, Kunimatsu, Akira, Kurdak, Hatice, Kwon, Young D., Lachat, Carl, Lagisz, Malgorzata, Laky, Brenda, Lammerding, Jan, Lange, Matthias, Larrosa, Mar, Laslett, Andrew L., Laverman, Gozewijn D., Leclair, Elizabeth E., Lee, Kyung-Woo, Lee, Ming-Yih, Lee, Moon-Soo, Li, Genyuan, Li, Jiansheng, Lieb, Klaus, Lim, Yau Y., Lindsey, Merry L., Line, Paul-Dag, Liu, Dengcai, Liu, Fengbin, Liu, Haiyan, Liu, Hongde, Lloyd, Vett K., Lo, Te-Wen, Locci, Emanuela, Loidl, Josef, Lorenzen, Johan, Lorkowski, Stefan, Lovell, Nigel H., Lu, Hua, Lu, Wei, Lu, Zhiyong, Luengo, Gustavo S., Lundh, Lars-Gunnar, Lysy, Philippe A., Mabb, Angela, Mack, Heather G., Mackey, David A., Mahdavi, S.R., Maher, Pamela, Maher, Toby, Maity, Sankar N., Malgrange, Brigitte, Mamoulakis, Charalampos, Mangoni, Arduino A., Manke, Thomas, Manstead, Antony S.R., Mantalaris, Athanasios, Marsal, Jan, Marschall, Hanns-Ulrich, Martin, Francis L., Martinez-Raga, Jose, Martinez-Salas, Encarnacion, Mathieu, Daniel, Matsui, Yoichi, Maza, Elie, McCutcheon, James E., McKay, Gareth J., McMillan, Brian, McMillan, Nigel, Meads, Catherine, Medina, Loreta, Merrick, B. Alex, Metzger, Dennis W., Meunier, Frederic A., Michaelis, Martin, Micheau, Olivier, Mihara, Hisaaki, Mintz, Eric M., Mizukami, Takuo, Moalic, Yann, Mohapatra, D.P., Monteiro, Antonia, Montes, Matthieu, Moran, John V., Morozov, Sergey Y., Mort, Matthew, Murai, Noriyuki, Murphy, Denis J., Murphy, Susan K., Murray, Shauna A., Naganawa, Shinji, Nammi, Srinivas, Nasios, Grigorios, Natoli, Roman M., Nguyen, Frederique, Nicol, Christine, van Nieuwerburgh, Filip, Nilsen, Erlend B., Nobile, Clarissa J., O'Mahony, Margaret, Ohlsson, Sophie, Olatunbosun, Oluremi, Olofsson, Per, Ortiz, Alberto, Ostrikov, Kostya, Otto, Siegmar, Outeiro, Tiago F., Ouyang, Songying, Paganoni, Sabrina, Page, Andrew, Palm, Christoph, Paradies, Yin, Parsons, Michael H., Parsons, Nick, Pascal, Pigny, Paul, Elisabeth, Peckham, Michelle, Pedemonte, Nicoletta, Pellizzon, Michael A., Petrelli, M., Pichugin, Alexander, Pinto, Carlos J.C., Plevris, John N., Pollesello, Piero, Polz, Martin, Ponti, Giovanna, Porcelli, Piero, Prince, Martin, Quinn, Gwendolyn P., Quinn, Terence J., Ramula, Satu, Rappsilber, Juri, Rehfeldt, Florian, Reiling, Jan H., Remacle, Claire, Rezaei, Mohsen, Riddick, Eric W., Ritter, Uwe, Roach, Neil W., Roberts, David D., Robles, Guillermo, Rodrigues, Tiago, Rodriguez, Cesar, Roislien, Jo, Roobol, Monique J., Rowe, Alexandra, Ruepp, Andreas, van Ruitenbeek, Jan, Rust, Petra, Saad, Sonia, Sack, George H., Santos, Manuela, Saudemont, Aurore, Sava, Gianni, Schrading, Simone, Schramm, Alexander, Schreiber, Martin, Schuler, Sidney, Schymkowitz, Joost, Sczyrba, Alexander, Seib, Kate L., Shi, Han-Ping, Shimada, Tomohiro, Shin, Jeon-Soo, Shortt, Colette, Silveyra, Patricia, Skinner, Debra, Small, Ian, Smeets, Paul A.M., So, Po-Wah, Solano, Francisco, Sonenshine, Daniel E., Song, Jiangning, Southall, Tony, Speakman, John R., Srinivasan, Mandyam V., Stabile, Laura P., Stasiak, Andrzej, Steadman, Kathryn J., Stein, Nils, Stephens, Andrew W., Stewart, Douglas I., Stine, Keith, Storlazzi, Curt, Stoynova, Nataliya V., Strzalka, Wojciech, Suarez, Oscar M., Sultana, Taranum, Sumant, Anirudha V., Summers, Mathew J., Sun, Gang, Tacon, Paul, Tanaka, Kozo, Tang, Haixu, Tanino, Y., Targett-Adams, Paul, Tayebi, Mourad, Tayyem, Reema, Tebbe, Christoph C., Telfer, Evelyn E., Tempel, Wolfram, Teodorczyk-Injeyan, Julita A., Thijs, Gert, Thorne, Sally, Thrift, Amanda G., Tiffon, Celine, Tinnefeld, Philip, Tjahjono, Daryono H., Tolle, Fabrice, Toth, Ervin, Del Tredici, Andria L., Tsapas, Apostolos, Tsirigotis, Konstantinos, Turak, Ayse, Tzotzos, George, Udo, Edet E., Utsumi, Toshiaki, Vaidyanathan, Subramanian, Vaillant, Michel, Valsesia, Armand, Vandenbroucke, Roosmarijn E., Veiga, Feliciano H., Vendrell, Marc, Vesk, Peter A., Vickers, Paul, Victor, Victor M., Villemur, Richard, Vohl, Marie-Claude, Voolstra, Christian R., Vuillemin, Anne, Wakelin, Steven, Waldron, Levi, Walsh, Laurence J., Wang, Amanda Y., Wang, Fuan, Wang, Yun, Watanabe, Yoichi, Weigert, Andreas, Wen, Jet-Chau, Wham, Carol, White, Ethan P., Wiener, Jan, Wilharm, Gottfried, Wilkinson, Simon, Willmann, Raffaella, Wilson, Coralie, Wirth, Brunhilde, Wojan, Timothy R., Wolff, Mathieu, Wong, Bryan M., Wu, Tzu-Wei, Wuerbel, Hanno, Xiao, Xiangshu, Xu, Dong, Xu, J.W., Xu, Jianping, Xue, Bin, Yalcin, Suayib, Yan, Hong, Yang, En-Cheng, Yang, Shiqi, Yang, Wei, Ye, Yuzhen, Ye, Zhi-Qiang, Yli-Kauhaluoma, Jari, Yoneyama, Hiroshi, Yu, Ying, Yuan, Guo-Cheng, Yuh, Chiou-Hwa, Zaccolo, Manuela, Zeng, Chen, Zevnik, Branko, Zhang, Chi, Zhang, Li, Zhang, Yingkai, Zhang, Yusen, Zhang, Zhiyong, Zhang, Zhong-Yin, Zhao, Yuan, Zhou, Min, Zuberbier, Torsten, Aanei, Carmen M., Ahmad, Rafi, Al-Lawama, Manar, Alanio, Alexandre, Allardyce, Judith, Alonso-Caneiro, David, Atack, John M., Baier, Dirk, Bansal, Abhisheka, Benezeth, Yannick, Berbesque, Colette, Berrevoet, Frederik, Biedermann, Peter H.W., Bijleveld, Erik, Bittner, Florian, Blombach, Fabian, van den Bos, Wouter, Boudreau, Shellie A., Bramoweth, Adam D., Braubach, Oliver, Cai, Yufeng, Campbell, Matthew, Cao, Zanxia, Catry, Thibault, Chen, Xin, Cheng, Shuiqin, Chung, Hee-Jung, Chávez-Fumagalli, Miguel A., Conway, Aaron, Costa, Bruno M., Cyr, Normand, Dean, Lorraine T., Denzel, Martin S., Dlamini, S.V., Dudley, Kevin J., Dufies, Maeva, Ecke, Thorsten, Eckweiler, Denitsa, Eixarch, Elisenda, El-Adawy, Hosny, Emmrich, Julius V., Eustace, Alex J., Falter-Wagner, Christine M., Farhoudi, Ramin, Fuss, Johannes, Gao, Jianzhao, Gill, Martin R., Gloyn, Liz, Goggs, Robert, Govinden, Usha, Greene, Garrett, Greiff, Victor, Grundle, D.S., Grüneberg, Patrick, Gumede, Nicksy, Haore, Gbaguidi, Harrison, Pille, Hoenner, Xavier, Hojsgaard, Diego, Hori, Hikaru, Ikonomopoulou, Maria P., Jeurissen, Patrick, Johnson, Daniel M., Kabra, Dhiraj, Kamagata, Koji, Karmakar, Chandan, Kasian, Olga, Kaye, Linda K., Khan, Murad M., Kim, Yong-Min, Kish, J.K., Kobold, Sebastian, Kohanbash, Gary, Kohls, Gregor, Kugler, Jan-Michael, Kumar, Gyanendra, Lacy-Colson, Jon, Latif, Asam, Lauschke, Volker M., Li, Bingling, Lim, Chinten J., Liu, Fang, Liu, Xiaodong, Lu, Jin-Jian, Lu, Qiang, Mahavadi, Poornima, Marzocchi, Ugo, McGarrigle, Christine A., van Meerten, Tom, Min, Rogier, Moal, Iain, Molari, Massimiliano, Molleman, Lucas, Mondal, Saiful R., van de Mortel, Thea, Moss, W.N., Moultos, Othonas A., Mukherjee, Maheswari, Nakayama, Kazuhiko, Narayan, Edward, Navaratnarajah, Neumann, Philipp-Alexander, Nie, Jiyun, Nie, Yingjiu, Niemeyer, Frank, Nolan, Fiona, Nwaiwu, Ogueri, Oldenmenger, Wendy H., Olumayede, Emmanuel, Ou, Jianhong, Pallebage-Gamarallage, Menuka, Pearce, Simon P., Pelkonen, Tuula, Pelleri, Maria C., Pereira, Joana L., Pheko, Mpho, Pinto, Karina A., Piovesan, Allison, Pluess, Michael, Podolsky, Illya M., Prescott, Julie, Qi, Dongchen, Qi, Xingshun, Raikou, Vaia D., Ranft, Andreas, Rhodes, Johanna, Rotge, Jean-Yves, Rowe, Anna D., Saggar, Manish, Schuon, Robert A., Shahid, Shaouli, Shalchyan, Vahid, Shirvalkar, Prasad, Shiryayev, Oleg, Singh, Jugpreet, Smout, Michael J., Soares, António, Song, Chunjiao, Srivastava, Kshitij, Srivastava, Rupesh K., Sun, Jim, Szabo, Attila, Szymanski, Wiktor, Tai, Chan N.P., Takeuchi, Hisashi, Tanadini-Lang, S., Tang, Fei, Tao, Wanyin, Theron, G., Tian, Chang F., Tian, Yu-Shi, Tuttle, Lisa M., Valenti, Anna, Verlot, Pierre, Walker, Mirella, Wang, Jun, Welter, Danielle, Winslade, Matthew, Wu, Dalei, Wu, Yi-Rui, Xiao, Han, Xu, Beisi, Xu, Juan, Xu, Ziyue, Yang, Dongdong, Yang, Mingjun, Yankilevich, Patricio, You, Yuyi, Yu, Chenglong, Zhan, Jian, Zhang, Gong, Zhang, Kai, Zhang, Tuo, Zhang, Yi, Zhao, Guoyan, Zhao, Jing, Zhou, Xiaofan, Zhu, Zhenxing, Ajani, Penelope A., Anazodo, Udunna C., Bagloee, Saeed A., Bail, Kasia, Bar, Ido, Bathelt, Joe, Benkeser, David, Bernier, Meghan L., Blanchard, Adam M., Boakye, Dominic W., Bonatsos, Vasileios, Boon, Michele H., Bouboulis, George, Bromfield, Elizabeth, Brown, Joshua, Bul, Kim C.M., Burton, Kathryn J., Butkowski, Eugene G., Carroll, Grace, Chao, Fengqing, Charrier, Elisabeth E., Chen, Xiaoyin, Chen, Yu-Chih, Chenguang, Choi, Jane R., Christoffersen, Tore, Comel, João C., Cosse, Cyril, Cui, Yanru, van Dessel, Pieter, Dhaval, Diodato, Daria, Duffey, Maelle, Dutt, Avik, Egea, Luis G., El-Said, Mohammed, Faye, Martin, Fernandez-Fernandez, Beatriz, Foley, Kieran G., Founou, Luria L., Fu, Fan, Gadelkareem, Rabea A., Galimov, Evgeny, Garip, Gulcan, Gemmill, Alison, Gouil, Quentin, Grey, James, Gridneva, Zoya, Grothe, Michel J., Grébert, Théophile, Guerrero, Fabricio, Guignard, Léo, Haenssgen, Marco J., Hasler, David, Holgate, Joan Y., Huang, Ancheng, Hulse-Kemp, Amanda M., Jean-Quartier, Claire, Jeon, Sang-Min, Jia, Yangyang, Jutzeler, Catherine, Kalatzis, Panagiotis, Karim, Masud, Karsay, Kathrin, Keitel, Anne, Kempe, Andreas, Keown, Jeremy R., Khoo, Chin M., Khwaja, Nyil, Kievit, Rogier A., Kosanic, Sasha, Koutoukidis, Dimitrios A., Kramer, Paul, Kumar, Dilip, Kiraǧ, Nükhet, Lanza, Giuseppe, Le, Thuc D., Leem, Jung W., Leightley, Daniel, Leite, 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Xu, Shilin, Yao, Ruifeng, Yao, Wen, Yin, Qinan, Yu, Yongbo, Zaitsu, Masayoshi, Zeineb, Zian, Zhan, Xiao-Yong, Zhang, Jilei, Zhang, Rongqiang, Zhang, Wei, Zhang, Xianglilan, Zheng, Shan, Zhou, Bailing, Zhou, Xiaoyan, Ahmad, Haroon, Akinwumi, Sayo A., Albery, Gregory F., Alhowimel, Ahmed, Ali, Junaid, Alshehri, Mansour, Alsuhaibani, Mohammed, Anikin, Andrey, Azubuike, Samuel O., Bach-Mortensen, Anders, Baltiansky, Lior, Bartas, Martin, Belachew, Kiflemariam Y., Bhardwaj, Vivek, Binder, Karin, Bland, Nicholas S., Boah, Michael, Bullen, Benjamin, Calabrò, Giovanna E., Callahan, Tiffany J., Cao, Bing, Chalmers, Kelsey, Chang, Wei, Che, Zhengping, Chen, Andrew T.Y., Chen, Haimin, Chen, Huaming, Chen, Youning, Chen, Zhao, Choi, Youngrok, Chowdhury, Mohiuddin A.K., Christensen, Martin R., Cooke, Robert S.C., Cottini, Marzia, Covington, Natalie V., Cunningham, Catriona, Delarocque, Julien, Devos, Lucie, Dhar, Aurup R., Ding, Ke-Feng, Dong, Kexian, Dong, Zheng, Dreyer, Niklas, Ekstrand, Chelsea, Fardet, Tanguy, Feleke, Berhanu E., Feurer, Thomas, Freitas, Angela, Gao, Tian, Gebremedhin, Giganti, Francesco, Grabowski, Piotr, Guerra-Mora, José R., Guo, Chengying, Guo, Xinyi, Gupta, Himanshu, He, Shuonan, Heijne, Marloes, Heinemann, Stephanie, Hogrebe, Alexander, Huang, Zhengping, Iskander-Rizk, Sophinese, Iyer, Lavanya M., Jahan, Yasmin, James, Ameh S., Joel, Emmanuel, Joffroy, Bastian, Jégousse, Clara, Kambondo, George, Karnati, Priyanka, Kaya, Cihan, Ke, An, Kelly, Daniel, Kickert, Rob, Kidibule, Peter E., Kieselmann, Jennifer P., Kim, Hyeon J., Kitazawa, Takeshi, Lamberts, Aniek, Li, You, Liang, Huakang, Linn, Sabrina N., Litfin, Thomas, Liusuo, Wang, Lygirou, Vasiliki, Mahato, Ajay K., Mai, Zhi-Ming, Major, Rupert W., Mali, Samira, Mallis, Panagiotis, Mao, Wenzhi, Marvin-Dowle, Katie, Mason, Leanda D., Merideth, Ben, Merino-Plaza, Maria J., Merlaen, Britt, Messina, Rossella, Mishra, Anand K., Muhammad, Junaid, Musinguzi, Conrad, Nanou, Afroditi, Naqash, Amreen, Nguyen, Joe T., Nguyen, Thi T.H., Ni, Duan, Nida, Notcovich, Shirli, Ohst, Barnabas, Ollivier, Quinn R., Osses, Daniël F., Peng, Xiangda, Plantinga, Arnoud, Pulia, Michael, Rafiq, Muhammad, Raman, Ayush, Raucher-Chéné, Rawski, Rafal, Ray, Asit, Razak, Lubna A., Rudolf, Kevin, Rusch, Peter, Sadoine, Margaux L., Schmidt, Axel, Schurr, Roey, Searles, Stephen, Sharma, Saurab, Sheehan, Barry, Shi, Chunhu, Shohayeb, Belal, Sommerlad, Andrew, Strehlow, Jan, Sun, Xianbao, Sundar, Raghav, Taherzadeh, Ghazaleh, Tahir, Nur D.M., Tang, Jun, Testa, Jean, Tian, Zhiqi, Tingting, Qian, Verheijen, Geert P., Vickstrom, Casey, Wang, Teng, Wang, Xiaomin, Wang, Zhenxing, Wei, Pan, Wilson, Alex, Wyart, Yassine, Abdul-Amir, Yousefzadeh, Abbas, Zare, Asma, Zeng, Zhen, Zhang, Chengrong, Zhang, Haowen, Zhang, Linxing, Zhang, Tongchuan, Zhang, Weijia, Zhang, Zhe, Zhou, Jianyu, Zhu, Dongjie, Adamo, Vincenzo, Adeyemo, Adebolajo A., Aggelidou, Maria, Al-Owaifeer, Adi M., Al-Riyami, Arwa Z., Alzghari, Saeed K., Andersen, Vibeke, Angus, Kathryn, Asaduzzaman, Muhammad, Asady, Hadi, Ato, Dai, Bai, Xiaoyong, Baines, Rebecca L., Ballantyne, Maghan, Ban, Bo, Beck, Jill, Ben-Nafa, Walid, Black, Emma, Blancher, Antoine, Blankstein, Ron, Bodagh, Neil, Borges, Paulo, Brooks, Anastasia, Brox-Ponce, Josue, Brunetti, Arturo, Canham, Colin D., Carninci, Piero, Carvajal, Richard, Chang, Shun C., Chao, Jie, Chatterjee, Pranab, Chen, He, Chen, Liming, Chen, Yi-Chun, Chhatriwalla, Adnan K., Chikowe, Ibrahim, Chuang, Trees-Juen, Collevatti, Rosane G., Cornejo, Diego A.V., Cuenda, Ana, Dao, Myriam, Dauga, Delphine, Deng, Zaian, Devkota, Kiran, Doan, Lisa V., Elewa, Yaser H.A., Fan, Dongsheng, Faruk, Mohammed, Feifei, Shi, Ferguson, Trevor S., Fleres, Francesco, Foster, Emma J., Foster, Stephen, Furer, Tzvi, Gao, Yibo, Garcia-Rivera, Enid J., Gazdar, Adi, George, Ronald B., Ghosh, Sayantan, Gianchecchi, Elena, Gleason, Joshua M., Hackshaw, Allan, Hall, Adam, Hall, Richard, Harper, Paul, Hogg, William E., Huang, Guangqun, 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Ricciardi, Walter, Riess, Olaf, Rovas, Alexandros, Sacks, Frank M., Saleh, Sherif, Sampson, Christopher, Schmutz, Axel, Sepanski, Robert, Sharma, Neeraj, Singh, Manisha, Spearman, Paul, Subramaniapillai, Mehala, Swali, Ritu, Tan, Cher M., Tellechea, Juan I., Thomas, Lisa-Marie, Tong, Xin, Vavvas, Demetrios G., Veys, Ralf, Vitriol, Veronica, Wang, Horng-Dar, Wang, Jinhui, Wang, Jiucun, Waugh, Jason, Webb, S.A., Williams, Brendan A., Workman, Alan D., Xiang, Tingxiu, Xie, Li-Xin, Xu, Jun, Xu, Taosheng, Yang, Chongjun, Yoon, Jihoon G., Yuan, Christina M., Zaritsky, Arno, Zhang, Yao, Zhao, Haochen, Zuckerman, Hannah, Lyu, Ran, Pullan, Wayne, Brown, Peter, Zhou, Yaoqi, Tan, Aik-Choon, El-Esawi, Mohamed A., Liehr, Thomas, Blanck, Oliver, Gladue, Douglas P., Almeida, Gabriel M.F., Cernava, Tomislav, Sorzano, Carlos O., Yeung, Andy W.K., Engel, Michael S., Chandrasekaran, Arun R., Muth, Thilo, Staege, Martin S., Daulatabad, Swapna V., Widera, Darius, Zhang, Junpeng, Meule, Adrian, Honjo, Ken, Pourret, Olivier, Yin, Cong-Cong, Zhang, Zhongheng, Cascella, Marco, Flegel, Willy A., Goodyear, Carl S., van Raaij, Mark J., Bukowy-Bieryllo, Zuzanna, Campana, Luca G., Kurniawan, Nicholas A., Lalaouna, David, Hüttner, Felix J., Ammerman, Brooke A., Ehret, Felix, Cobine, Paul A., Tan, Ene-Choo, Han, Hyemin, Xia, Wenfeng, McCrum, Christopher, Dings, Ruud P.M., Marinello, Francesco, Nilsson, Henrik, Nixon, Brett, Voskarides, Konstantinos, Yang, Long, Costa, Vincent D., Bengtsson-Palme, Johan, Bradshaw, William, Grimm, Dominik G., Kumar, Nitin, Martis, Elvis, Prieto, Daniel, Sabnis, Sandeep C., Amer, Said E.D.R., Liew, Alan W.C., Perco, Paul, Rahimi, Farid, Riva, Giuseppe, Zhang, Chongxing, Devkota, Hari P., Ogami, Koichi, Basharat, Zarrin, Fierz, Walter, Siebers, Robert, Tan, Kok H., Boehme, Karen A., Brenneisen, Peter, Brown, James A.L., Dalrymple, Brian P., Harvey, David J., Ng, Grace, Werten, Sebastiaan, Bleackley, Mark, Dai, Zhanwu, Dhariwal, Raman, Gelfer, Yael, Hartmann, Marcus 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Stefan, Kinyanjui, Timothy, Koleva-Kolarova, Rositsa G., Li, Zhixiu, Liu, Yu-Peng, Lund, Bjarte A., Lussier, Alexandre A., Ma, Liping, Mier, Pablo, Moore, Matthew D., Nagler, Katja, Orme, Mark W., Pearson, James A., Prajapati, Anilkumar S., Saito, Yu, Tröder, Simon E., Uchendu, Florence, Verloh, Niklas, Voutchkova, Denitza D., Abu-Zaid, Ahmed, Bakkach, Joaira, Baumert, Philipp, Dono, Marcos, Hanson, Jack, Herbelet, Sandrine, Hobbs, Emma, Kulkarni, Ameya, Kumar, Narendra, Liu, Siqi, Loft, Nikolai D., Reddan, Tristan, Senghore, Thomas, Vindin, Howard, Xu, Haotian, Bannon, Ross, Chen, Branson, Cheung, Johnny T.K., Cooper, Jeffrey, Esnakula, Ashwini K., Feghali, Karine A., Ghelardi, Emilia, Gnasso, Agostino, Horbar, Jeffrey, Lai, Hei M., Li, Jian, Ma, Lan, Ma, Ruiyan, Pan, Zihang, Peres, Marco A., Pranata, Raymond, Seow, Esmond, Sydes, Matthew, Testoni, Ines, Westermair, Anna L., Yang, Yongliang, Afnan, Masoud, Albiol, Joan, Albuquerque, Lucia G., Amir, Shimon, Amiya, Eisuke, Amorim, Rogerio M., An, Qianli, Andersen, Stig U., Aplin, John D., Argyropoulos, Christos, Asmann, Yan W., Assaeed, Abdulaziz M., Atanasov, Atanas G., Atchison, David A., Avery, Simon V., Avillach, Paul, Baade, Peter D., Backman, Lars, Badie, Christophe, Baldi, Alfonso, Ball, Elizabeth, Bardot, Olivier, Barnett, Adrian G., Basner, Mathias, Batra, Jyotsna, Bazanova, O.M., Beale, Andrew, Beddoe, Travis, Bell, Melanie L., Berezikov, Eugene, Berners-Price, Sue, Bernhardt, Peter, Berry, Edward, Bessa, Theolis B., Billington, Craig, Birch, John, Blakely, Randy D., Blaskovich, Mark A.T., Blum, Robert, Boelaert, Marleen, Bogdanos, Dimitrios, Bosch, Carles, Bourgoin, Thierry, Bouvard, Daniel, Boykin, Laura M., Bradley, Graeme, Braun, Daniel, Brownlie, Jeremy, Brühl, Albert, Burt, Austin, Butler, Lisa M., Byrareddy, Siddappa N., Byrne, Hugh J., Cabantous, Stephanie, Calatayud, Sara, Candal, Eva, Carlson, Kimberly, Casillas, Sònia, Castelvetro, Valter, Caswell, Patrick T., Cavalli, Giacomo, Cerovsky, 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Guoku, Huber, Heinz P., Hueso, Luis E., Huirne, Judith, Hurt, Lisa, Idborg, Helena, Ikeo, Kazuho, Ingley, Evan, Jakeman, Philip M., Jensen, Arne, Jia, Hong, Jia, Husen, Jia, Shuqin, Jiang, Jianping, Jiang, Xingyu, Jin, Yi, Jo, Daehyun, Johnson, Andrew M., Johnston, Marie, Jonscher, Karen R., Jorens, Philippe G., Jorgensen, Jens O.L., Joubert, Johan W., Jung, Sin-Ho, Junior, Antonio M., Kahan, Thomas, Kamboj, Sunjeev K., Kang, Yong-Kook, Karamanos, Yannis, Karp, Natasha A., Kelly, Ryan, Kenna, Ralph, Kennedy, Jonathan, Kersten, Birgit, Khalaf, Roy A., Khalid, Javaria M., Khatlani, T., Khider, Tarig, Kijanka, Gregor S., King, Sarah R.B., Kluz, Tomasz, Knox, Paul, Kobayashi, Tatsuya, Koch, Karl-Wilhelm, Kohonen-Corish, Maija R.J., Kong, Xiangpeng, Konkle-Parker, Deborah, Korpela, Kalevi M., Kostrikis, Leondios G., Kraiczy, Peter, Kratz, Harald, Krause, Günter, Krebsbach, Paul H., Kristensen, Søren R., Kumari, Prerna, Kunimatsu, Akira, Kurdak, Hatice, Kwon, Young D., Lachat, Carl, Lagisz, Malgorzata, Laky, Brenda, Lammerding, Jan, Lange, Matthias, Larrosa, Mar, Laslett, Andrew L., Laverman, Gozewijn D., Leclair, Elizabeth E., Lee, Kyung-Woo, Lee, Ming-Yih, Lee, Moon-Soo, Li, Genyuan, Li, Jiansheng, Lieb, Klaus, Lim, Yau Y., Lindsey, Merry L., Line, Paul-Dag, Liu, Dengcai, Liu, Fengbin, Liu, Haiyan, Liu, Hongde, Lloyd, Vett K., Lo, Te-Wen, Locci, Emanuela, Loidl, Josef, Lorenzen, Johan, Lorkowski, Stefan, Lovell, Nigel H., Lu, Hua, Lu, Wei, Lu, Zhiyong, Luengo, Gustavo S., Lundh, Lars-Gunnar, Lysy, Philippe A., Mabb, Angela, Mack, Heather G., Mackey, David A., Mahdavi, S.R., Maher, Pamela, Maher, Toby, Maity, Sankar N., Malgrange, Brigitte, Mamoulakis, Charalampos, Mangoni, Arduino A., Manke, Thomas, Manstead, Antony S.R., Mantalaris, Athanasios, Marsal, Jan, Marschall, Hanns-Ulrich, Martin, Francis L., Martinez-Raga, Jose, Martinez-Salas, Encarnacion, Mathieu, Daniel, Matsui, Yoichi, Maza, Elie, McCutcheon, James E., McKay, Gareth J., McMillan, Brian, McMillan, Nigel, Meads, Catherine, Medina, Loreta, Merrick, B. Alex, Metzger, Dennis W., Meunier, Frederic A., Michaelis, Martin, Micheau, Olivier, Mihara, Hisaaki, Mintz, Eric M., Mizukami, Takuo, Moalic, Yann, Mohapatra, D.P., Monteiro, Antonia, Montes, Matthieu, Moran, John V., Morozov, Sergey Y., Mort, Matthew, Murai, Noriyuki, Murphy, Denis J., Murphy, Susan K., Murray, Shauna A., Naganawa, Shinji, Nammi, Srinivas, Nasios, Grigorios, Natoli, Roman M., Nguyen, Frederique, Nicol, Christine, van Nieuwerburgh, Filip, Nilsen, Erlend B., Nobile, Clarissa J., O'Mahony, Margaret, Ohlsson, Sophie, Olatunbosun, Oluremi, Olofsson, Per, Ortiz, Alberto, Ostrikov, Kostya, Otto, Siegmar, Outeiro, Tiago F., Ouyang, Songying, Paganoni, Sabrina, Page, Andrew, Palm, Christoph, Paradies, Yin, Parsons, Michael H., Parsons, Nick, Pascal, Pigny, Paul, Elisabeth, Peckham, Michelle, Pedemonte, Nicoletta, Pellizzon, Michael A., Petrelli, M., Pichugin, Alexander, Pinto, Carlos J.C., Plevris, John N., Pollesello, Piero, Polz, Martin, Ponti, Giovanna, Porcelli, Piero, Prince, Martin, Quinn, Gwendolyn P., Quinn, Terence J., Ramula, Satu, Rappsilber, Juri, Rehfeldt, Florian, Reiling, Jan H., Remacle, Claire, Rezaei, Mohsen, Riddick, Eric W., Ritter, Uwe, Roach, Neil W., Roberts, David D., Robles, Guillermo, Rodrigues, Tiago, Rodriguez, Cesar, Roislien, Jo, Roobol, Monique J., Rowe, Alexandra, Ruepp, Andreas, van Ruitenbeek, Jan, Rust, Petra, Saad, Sonia, Sack, George H., Santos, Manuela, Saudemont, Aurore, Sava, Gianni, Schrading, Simone, Schramm, Alexander, Schreiber, Martin, Schuler, Sidney, Schymkowitz, Joost, Sczyrba, Alexander, Seib, Kate L., Shi, Han-Ping, Shimada, Tomohiro, Shin, Jeon-Soo, Shortt, Colette, Silveyra, Patricia, Skinner, Debra, Small, Ian, Smeets, Paul A.M., So, Po-Wah, Solano, Francisco, Sonenshine, Daniel E., Song, Jiangning, Southall, Tony, Speakman, John R., Srinivasan, Mandyam V., Stabile, Laura P., Stasiak, Andrzej, Steadman, Kathryn J., Stein, Nils, Stephens, Andrew W., Stewart, Douglas I., Stine, Keith, Storlazzi, Curt, Stoynova, Nataliya V., Strzalka, Wojciech, Suarez, Oscar M., Sultana, Taranum, Sumant, Anirudha V., Summers, Mathew J., Sun, Gang, Tacon, Paul, Tanaka, Kozo, Tang, Haixu, Tanino, Y., Targett-Adams, Paul, Tayebi, Mourad, Tayyem, Reema, Tebbe, Christoph C., Telfer, Evelyn E., Tempel, Wolfram, Teodorczyk-Injeyan, Julita A., Thijs, Gert, Thorne, Sally, Thrift, Amanda G., Tiffon, Celine, Tinnefeld, Philip, Tjahjono, Daryono H., Tolle, Fabrice, Toth, Ervin, Del Tredici, Andria L., Tsapas, Apostolos, Tsirigotis, Konstantinos, Turak, Ayse, Tzotzos, George, Udo, Edet E., Utsumi, Toshiaki, Vaidyanathan, Subramanian, Vaillant, Michel, Valsesia, Armand, Vandenbroucke, Roosmarijn E., Veiga, Feliciano H., Vendrell, Marc, Vesk, Peter A., Vickers, Paul, Victor, Victor M., Villemur, Richard, Vohl, Marie-Claude, Voolstra, Christian R., Vuillemin, Anne, Wakelin, Steven, Waldron, Levi, Walsh, Laurence J., Wang, Amanda Y., Wang, Fuan, Wang, Yun, Watanabe, Yoichi, Weigert, Andreas, Wen, Jet-Chau, Wham, Carol, White, Ethan P., Wiener, Jan, Wilharm, Gottfried, Wilkinson, Simon, Willmann, Raffaella, Wilson, Coralie, Wirth, Brunhilde, Wojan, Timothy R., Wolff, Mathieu, Wong, Bryan M., Wu, Tzu-Wei, Wuerbel, Hanno, Xiao, Xiangshu, Xu, Dong, Xu, J.W., Xu, Jianping, Xue, Bin, Yalcin, Suayib, Yan, Hong, Yang, En-Cheng, Yang, Shiqi, Yang, Wei, Ye, Yuzhen, Ye, Zhi-Qiang, Yli-Kauhaluoma, Jari, Yoneyama, Hiroshi, Yu, Ying, Yuan, Guo-Cheng, Yuh, Chiou-Hwa, Zaccolo, Manuela, Zeng, Chen, Zevnik, Branko, Zhang, Chi, Zhang, Li, Zhang, Yingkai, Zhang, Yusen, Zhang, Zhiyong, Zhang, Zhong-Yin, Zhao, Yuan, Zhou, Min, Zuberbier, Torsten, Aanei, Carmen M., Ahmad, Rafi, Al-Lawama, Manar, Alanio, Alexandre, Allardyce, Judith, Alonso-Caneiro, David, Atack, John M., Baier, Dirk, Bansal, Abhisheka, Benezeth, Yannick, Berbesque, Colette, Berrevoet, Frederik, Biedermann, Peter H.W., Bijleveld, Erik, Bittner, Florian, Blombach, Fabian, van den Bos, Wouter, Boudreau, Shellie A., Bramoweth, Adam D., Braubach, Oliver, Cai, Yufeng, Campbell, Matthew, Cao, Zanxia, Catry, Thibault, Chen, Xin, Cheng, Shuiqin, Chung, Hee-Jung, Chávez-Fumagalli, Miguel A., Conway, Aaron, Costa, Bruno M., Cyr, Normand, Dean, Lorraine T., Denzel, Martin S., Dlamini, S.V., Dudley, Kevin J., Dufies, Maeva, Ecke, Thorsten, Eckweiler, Denitsa, Eixarch, Elisenda, El-Adawy, Hosny, Emmrich, Julius V., Eustace, Alex J., Falter-Wagner, Christine M., Farhoudi, Ramin, Fuss, Johannes, Gao, Jianzhao, Gill, Martin R., Gloyn, Liz, Goggs, Robert, Govinden, Usha, Greene, Garrett, Greiff, Victor, Grundle, D.S., Grüneberg, Patrick, Gumede, Nicksy, Haore, Gbaguidi, Harrison, Pille, Hoenner, Xavier, Hojsgaard, Diego, Hori, Hikaru, Ikonomopoulou, Maria P., Jeurissen, Patrick, Johnson, Daniel M., Kabra, Dhiraj, Kamagata, Koji, Karmakar, Chandan, Kasian, Olga, Kaye, Linda K., Khan, Murad M., Kim, Yong-Min, Kish, J.K., Kobold, Sebastian, Kohanbash, Gary, Kohls, Gregor, Kugler, Jan-Michael, Kumar, Gyanendra, Lacy-Colson, Jon, Latif, Asam, Lauschke, Volker M., Li, Bingling, Lim, Chinten J., Liu, Fang, Liu, Xiaodong, Lu, Jin-Jian, Lu, Qiang, Mahavadi, Poornima, Marzocchi, Ugo, McGarrigle, Christine A., van Meerten, Tom, Min, Rogier, Moal, Iain, Molari, Massimiliano, Molleman, Lucas, Mondal, Saiful R., van de Mortel, Thea, Moss, W.N., Moultos, Othonas A., Mukherjee, Maheswari, Nakayama, Kazuhiko, Narayan, Edward, Navaratnarajah, Neumann, Philipp-Alexander, Nie, Jiyun, Nie, Yingjiu, Niemeyer, Frank, Nolan, Fiona, Nwaiwu, Ogueri, Oldenmenger, Wendy H., Olumayede, Emmanuel, Ou, Jianhong, Pallebage-Gamarallage, Menuka, Pearce, Simon P., Pelkonen, Tuula, Pelleri, Maria C., Pereira, Joana L., Pheko, Mpho, Pinto, Karina A., Piovesan, Allison, Pluess, Michael, Podolsky, Illya M., Prescott, Julie, Qi, Dongchen, Qi, Xingshun, Raikou, Vaia D., Ranft, Andreas, Rhodes, Johanna, Rotge, Jean-Yves, Rowe, Anna D., Saggar, Manish, Schuon, Robert A., Shahid, Shaouli, Shalchyan, Vahid, Shirvalkar, Prasad, Shiryayev, Oleg, Singh, Jugpreet, Smout, Michael J., Soares, António, Song, Chunjiao, Srivastava, Kshitij, Srivastava, Rupesh K., Sun, Jim, Szabo, Attila, Szymanski, Wiktor, Tai, Chan N.P., Takeuchi, Hisashi, Tanadini-Lang, S., Tang, Fei, Tao, Wanyin, Theron, G., Tian, Chang F., Tian, Yu-Shi, Tuttle, Lisa M., Valenti, Anna, Verlot, Pierre, Walker, Mirella, Wang, Jun, Welter, Danielle, Winslade, Matthew, Wu, Dalei, Wu, Yi-Rui, Xiao, Han, Xu, Beisi, Xu, Juan, Xu, Ziyue, Yang, Dongdong, Yang, Mingjun, Yankilevich, Patricio, You, Yuyi, Yu, Chenglong, Zhan, Jian, Zhang, Gong, Zhang, Kai, Zhang, Tuo, Zhang, Yi, Zhao, Guoyan, Zhao, Jing, Zhou, Xiaofan, Zhu, Zhenxing, Ajani, Penelope A., Anazodo, Udunna C., Bagloee, Saeed A., Bail, Kasia, Bar, Ido, Bathelt, Joe, Benkeser, David, Bernier, Meghan L., Blanchard, Adam M., Boakye, Dominic W., Bonatsos, Vasileios, Boon, Michele H., Bouboulis, George, Bromfield, Elizabeth, Brown, Joshua, Bul, Kim C.M., Burton, Kathryn J., Butkowski, Eugene G., Carroll, Grace, Chao, Fengqing, Charrier, Elisabeth E., Chen, Xiaoyin, Chen, Yu-Chih, Chenguang, Choi, Jane R., Christoffersen, Tore, Comel, João C., Cosse, Cyril, Cui, Yanru, van Dessel, Pieter, Dhaval, Diodato, Daria, Duffey, Maelle, Dutt, Avik, Egea, Luis G., El-Said, Mohammed, Faye, Martin, Fernandez-Fernandez, Beatriz, Foley, Kieran G., Founou, Luria L., Fu, Fan, Gadelkareem, Rabea A., Galimov, Evgeny, Garip, Gulcan, Gemmill, Alison, Gouil, Quentin, Grey, James, Gridneva, Zoya, Grothe, Michel J., Grébert, Théophile, Guerrero, Fabricio, Guignard, Léo, Haenssgen, Marco J., Hasler, David, Holgate, Joan Y., Huang, Ancheng, Hulse-Kemp, Amanda M., Jean-Quartier, Claire, Jeon, Sang-Min, Jia, Yangyang, Jutzeler, Catherine, Kalatzis, Panagiotis, Karim, Masud, Karsay, Kathrin, Keitel, Anne, Kempe, Andreas, Keown, Jeremy R., Khoo, Chin M., Khwaja, Nyil, Kievit, Rogier A., Kosanic, Sasha, Koutoukidis, Dimitrios A., Kramer, Paul, Kumar, Dilip, Kiraǧ, Nükhet, Lanza, Giuseppe, Le, Thuc D., Leem, Jung W., Leightley, Daniel, Leite, Andreia, Lercher, Lukas, Li, Ying, Lim, Renly, Lima, Luiz R.A., Lin, Li, Ling, Tong, Liu, Yuchen, Liu, Zhonghua, Lu, Yao, Lum, Fok M., Luo, Hang, Machhi, Jatin, Macleod, Angus, Macwan, Isaac, Madala, Hanumantha R., Madani, Nima, de Maio, Nicola, Makowiecki, Kalina, Mallinson, Daniel J., Margelyte, Ruta, Maria, Caracausi, Markonis, Y., Marsili, Luca, Mavoa, Suzanne, McWilliams, Lorna, Megersa, Moa, Souto-Maior, Caetano, Menichetti, Julia, Mercieca-Bebber, Rebecca, Miller, Jack J., Minde, David-Paul M., Minges, Alexander, Mishra, Eleanor, Mishra, Virendra R., Moores, Carly, Morrice, Nicola, Moskalensky, Alexander E., Navarin, Nicolò, Negera, Edessa, Nolet, Philippe, Nordberg, Ana, Nordén, Rickard, Nowicki, Jessica P., Olova, Nelly, Olszewski, Pawel, Onzima, Robert, Pan, Chih-Long, Park, Charny, Park, Dong I., Park, Seyoung, Patil, Chandrashekhar D., Pedro, Sansoa A., Perry, Samuel R., Peter, Jessica, Peterson, Brent M., Pezzuolo, Andrea, Pozdnyakov, Ilya, Qian, Siyu, Qin, Lei, Rafe, Ali, Raote, Ishier, Raza, Ali, Rebl, Henrike, Refai, Osama, Regan, Tim, Richa, Tambi, Richardson, Mark F., Robinson, K.R., Rossoni, Luca, Rouet, Romain, Safaei, Soroush, Schneeberger, Pierre H.H., Schwotzer, Daniela, Sebastian, Agata, Selinski, Jennifer, Seltmann, Stefanie, Sha, Feng, Shalev, Nir, Shang, Jin-Long, Singer, Josef, Singh, Mandeep, Smith, Taylor, Solomon-Moore, Emma, Song, Lijuan, Soraggi, Samuele, Stanley, Ryan, Steckhan, Nico, Strobl, Frederic, Subissi, Lorenzo, Supriyanto, Irwan, Surve, Chinmay R., Suzuki, Tomo, Syme, Caitlin, Sörelius, Karl, Tang, Young, Tantawy, Marwa, Tennakoon, Sumudu, Teseo, Serafino, Toelzer, Christine, Tomov, Nikola, Tovar, Miguel, Tran, Linh, Tripathi, Sushil, Tuladhar, Anil M., Ukubuiwe, Azubuike C., Ung, Carolina O.L., Valgepea, Kaspar, Vatanparast, Hamid, Vidal, Arnau, Wang, Fang, Wang, Qing, Watari, Ricky, Webster, Rebecca, Webster, Ruth, Wei, Junnian, Wibowo, David, Wingenbach, Tanja S.H., Xavier, Rose M., Xiao, Shumin, Xiong, Peng, Xu, Shicai, Xu, Shilin, Yao, Ruifeng, Yao, Wen, Yin, Qinan, Yu, Yongbo, Zaitsu, Masayoshi, Zeineb, Zian, Zhan, Xiao-Yong, Zhang, Jilei, Zhang, Rongqiang, Zhang, Wei, Zhang, Xianglilan, Zheng, Shan, Zhou, Bailing, Zhou, Xiaoyan, Ahmad, Haroon, Akinwumi, Sayo A., Albery, Gregory F., Alhowimel, Ahmed, Ali, Junaid, Alshehri, Mansour, Alsuhaibani, Mohammed, Anikin, Andrey, Azubuike, Samuel O., Bach-Mortensen, Anders, Baltiansky, Lior, Bartas, Martin, Belachew, Kiflemariam Y., Bhardwaj, Vivek, Binder, Karin, Bland, Nicholas S., Boah, Michael, Bullen, Benjamin, Calabrò, Giovanna E., Callahan, Tiffany J., Cao, Bing, Chalmers, Kelsey, Chang, Wei, Che, Zhengping, Chen, Andrew T.Y., Chen, Haimin, Chen, Huaming, Chen, Youning, Chen, Zhao, Choi, Youngrok, Chowdhury, Mohiuddin A.K., Christensen, Martin R., Cooke, Robert S.C., Cottini, Marzia, Covington, Natalie V., Cunningham, Catriona, Delarocque, Julien, Devos, Lucie, Dhar, Aurup R., Ding, Ke-Feng, Dong, Kexian, Dong, Zheng, Dreyer, Niklas, Ekstrand, Chelsea, Fardet, Tanguy, Feleke, Berhanu E., Feurer, Thomas, Freitas, Angela, Gao, Tian, Gebremedhin, Giganti, Francesco, Grabowski, Piotr, Guerra-Mora, José R., Guo, Chengying, Guo, Xinyi, Gupta, Himanshu, He, Shuonan, Heijne, Marloes, Heinemann, Stephanie, Hogrebe, Alexander, Huang, Zhengping, Iskander-Rizk, Sophinese, Iyer, Lavanya M., Jahan, Yasmin, James, Ameh S., Joel, Emmanuel, Joffroy, Bastian, Jégousse, Clara, Kambondo, George, Karnati, Priyanka, Kaya, Cihan, Ke, An, Kelly, Daniel, Kickert, Rob, Kidibule, Peter E., Kieselmann, Jennifer P., Kim, Hyeon J., Kitazawa, Takeshi, Lamberts, Aniek, Li, You, Liang, Huakang, Linn, Sabrina N., Litfin, Thomas, Liusuo, Wang, Lygirou, Vasiliki, Mahato, Ajay K., Mai, Zhi-Ming, Major, Rupert W., Mali, Samira, Mallis, Panagiotis, Mao, Wenzhi, Marvin-Dowle, Katie, Mason, Leanda D., Merideth, Ben, Merino-Plaza, Maria J., Merlaen, Britt, Messina, Rossella, Mishra, Anand K., Muhammad, Junaid, Musinguzi, Conrad, Nanou, Afroditi, Naqash, Amreen, Nguyen, Joe T., Nguyen, Thi T.H., Ni, Duan, Nida, Notcovich, Shirli, Ohst, Barnabas, Ollivier, Quinn R., Osses, Daniël F., Peng, Xiangda, Plantinga, Arnoud, Pulia, Michael, Rafiq, Muhammad, Raman, Ayush, Raucher-Chéné, Rawski, Rafal, Ray, Asit, Razak, Lubna A., Rudolf, Kevin, Rusch, Peter, Sadoine, Margaux L., Schmidt, Axel, Schurr, Roey, Searles, Stephen, Sharma, Saurab, Sheehan, Barry, Shi, Chunhu, Shohayeb, Belal, Sommerlad, Andrew, Strehlow, Jan, Sun, Xianbao, Sundar, Raghav, Taherzadeh, Ghazaleh, Tahir, Nur D.M., Tang, Jun, Testa, Jean, Tian, Zhiqi, Tingting, Qian, Verheijen, Geert P., Vickstrom, Casey, Wang, Teng, Wang, Xiaomin, Wang, Zhenxing, Wei, Pan, Wilson, Alex, Wyart, Yassine, Abdul-Amir, Yousefzadeh, Abbas, Zare, Asma, Zeng, Zhen, Zhang, Chengrong, Zhang, Haowen, Zhang, Linxing, Zhang, Tongchuan, Zhang, Weijia, Zhang, Zhe, Zhou, Jianyu, Zhu, Dongjie, Adamo, Vincenzo, Adeyemo, Adebolajo A., Aggelidou, Maria, Al-Owaifeer, Adi M., Al-Riyami, Arwa Z., Alzghari, Saeed K., Andersen, Vibeke, Angus, Kathryn, Asaduzzaman, Muhammad, Asady, Hadi, Ato, Dai, Bai, Xiaoyong, Baines, Rebecca L., Ballantyne, Maghan, Ban, Bo, Beck, Jill, Ben-Nafa, Walid, Black, Emma, Blancher, Antoine, Blankstein, Ron, Bodagh, Neil, Borges, Paulo, Brooks, Anastasia, Brox-Ponce, Josue, Brunetti, Arturo, Canham, Colin D., Carninci, Piero, Carvajal, Richard, Chang, Shun C., Chao, Jie, Chatterjee, Pranab, Chen, He, Chen, Liming, Chen, Yi-Chun, Chhatriwalla, Adnan K., Chikowe, Ibrahim, Chuang, Trees-Juen, Collevatti, Rosane G., Cornejo, Diego A.V., Cuenda, Ana, Dao, Myriam, Dauga, Delphine, Deng, Zaian, Devkota, Kiran, Doan, Lisa V., Elewa, Yaser H.A., Fan, Dongsheng, Faruk, Mohammed, Feifei, Shi, Ferguson, Trevor S., Fleres, Francesco, Foster, Emma J., Foster, Stephen, Furer, Tzvi, Gao, Yibo, Garcia-Rivera, Enid J., Gazdar, Adi, George, Ronald B., Ghosh, Sayantan, Gianchecchi, Elena, Gleason, Joshua M., Hackshaw, Allan, Hall, Adam, Hall, Richard, Harper, Paul, Hogg, William E., Huang, Guangqun, Hunter, Kylie E., Ijzerman, Adriaan P., Jesus, Carlos, Jian, Gao, Lewis, James S., Kanj, Souha S., Kaur, Harsheen, Kelly, Shona, Kheir, Fayez, Kichatova, V.S., Kiyani, Musa, Klein, Reinhild, Kovesi, Tom, Kraschnewski, Jennifer L., Kumar, Addanki P., Labutin, Dmitry, Lazo-Langner, Alejandro, Leclercq, Guy, Li, Maoteng, Li, Qingchun, Li, Tangliang, Li, Yongzhe, Liao, Wei-Ting, Liao, Zheng-Yin, Lin, Jessica, Lizer, J., Lobreglio, Giambattista, Lowies, Cher, Lu, Cheng, Majeed, Haroon, Martin, Adam, Martinez-Sobrido, Luis, Meresh, Edwin, Middelveen, Marianne, Mohebbi, Alireza, Mota, Jorge, Mozaheb, Zahra, Muyaya, Ley, Nandhakumar, Amar, Ng, Sheryl H.X., Obeidat, Monther, Oh, Deog-Hwan, Owais, Mohammed, Pace-Asciak, Pia, Panwar, Ajay, Park, Caroline, Patterson, Chris, Penagos-Tabaree, Felipe, Pianosi, Paolo T., Pinzi, Valentina, Pridans, Clare, Psaroulaki, Anna, Pujala, Ravi K., Pulido-Arjona, Leonardo, Qi, Peng-Fei, Rahman, Proton, Rai, Nayanjot K., Rassaf, Tienush, Refardt, Julie, Ricciardi, Walter, Riess, Olaf, Rovas, Alexandros, Sacks, Frank M., Saleh, Sherif, Sampson, Christopher, Schmutz, Axel, Sepanski, Robert, Sharma, Neeraj, Singh, Manisha, Spearman, Paul, Subramaniapillai, Mehala, Swali, Ritu, Tan, Cher M., Tellechea, Juan I., Thomas, Lisa-Marie, Tong, Xin, Vavvas, Demetrios G., Veys, Ralf, Vitriol, Veronica, Wang, Horng-Dar, Wang, Jinhui, Wang, Jiucun, Waugh, Jason, Webb, S.A., Williams, Brendan A., Workman, Alan D., Xiang, Tingxiu, Xie, Li-Xin, Xu, Jun, Xu, Taosheng, Yang, Chongjun, Yoon, Jihoon G., Yuan, Christina M., Zaritsky, Arno, Zhang, Yao, Zhao, Haochen, Zuckerman, Hannah, Lyu, Ran, and Pullan, Wayne
- Abstract
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science.
- Published
- 2019
85. The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.
- Author
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Fredriksson, Robert, Sreedharan, Smitha, Nordenankar, Karin, Alsiö, Johan, Lindberg, Frida A., Hutchinson, Ashley, Eriksson, Anders, Roshanbin, Sahar, Ciuculete, Diana M, Klockars, Anica, Todkar, Aniruddha, Hägglund, Maria G, Hellsten, Sofie V, Hindlycke, Viktoria, Västermark, Åke, Shevchenko, Ganna, Olivo, Gaia, K, Cheng, Kullander, Klas, Moazzami, Ali, Bergquist, Jonas, Olszewski, Pawel K., Schiöth, Helgi B., Fredriksson, Robert, Sreedharan, Smitha, Nordenankar, Karin, Alsiö, Johan, Lindberg, Frida A., Hutchinson, Ashley, Eriksson, Anders, Roshanbin, Sahar, Ciuculete, Diana M, Klockars, Anica, Todkar, Aniruddha, Hägglund, Maria G, Hellsten, Sofie V, Hindlycke, Viktoria, Västermark, Åke, Shevchenko, Ganna, Olivo, Gaia, K, Cheng, Kullander, Klas, Moazzami, Ali, Bergquist, Jonas, Olszewski, Pawel K., and Schiöth, Helgi B.
- Abstract
SLC18B1 is a sister gene to the vesicular monoamine and acetylcholine transporters, and the only known polyamine transporter, with unknown physiological role. We reveal that Slc18b1 knock out mice has significantly reduced polyamine content in the brain providing the first evidence that Slc18b1 is functionally required for regulating polyamine levels. We found that this mouse has impaired short and long term memory in novel object recognition, radial arm maze and self-administration paradigms. We also show that Slc18b1 KO mice have altered expression of genes involved in Long Term Potentiation, plasticity, calcium signalling and synaptic functions and that expression of components of GABA and glutamate signalling are changed. We further observe a partial resistance to diazepam, manifested as significantly lowered reduction in locomotion after diazepam treatment. We suggest that removal of Slc18b1 leads to reduction of polyamine contents in neurons, resulting in reduced GABA signalling due to long-term reduction in glutamatergic signalling.
- Published
- 2019
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86. Minireview: Characterization of Influence of Central Nociceptin/Orphanin FQ on Consummatory Behavior
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Olszewski, Pawel K. and Levine, Allen S.
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- 2004
87. Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity
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Olszewski, Pawel K, Grace, Martha K, Billington, Charles J, and Levine, Allen S
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- 2003
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88. Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus
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Olszewski, Pawel K, Li, Dehong, Grace, Martha K, Billington, Charles J, Kotz, Catherine M, and Levine, Allen S
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- 2003
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89. Agouti-Related Protein: Appetite or Reward?
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OLSZEWSKI, PAWEL K., WICKWIRE, KATHIE, WIRTH, MICHELLE M., LEVINE, ALLEN S., and GIRAUDO, SILVIA Q.
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- 2003
90. Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract
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Badiali Luca, Cedernaes Jonathan, Olszewski Pawel K, Nylander Olof, Vergoni Anna V, and Schiöth Helgi B
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background G protein-coupled receptors (GPCRs) represent one of the largest families of transmembrane receptors and the most common drug target. The Adhesion subfamily is the second largest one of GPCRs and its several members are known to mediate neural development and immune system functioning through cell-cell and cell-matrix interactions. The distribution of these receptors has not been characterized in detail in the gastrointestinal (GI) tract. Here we present the first comprehensive anatomical profiling of mRNA expression of all 30 Adhesion GPCRs in the rat GI tract divided into twelve subsegments. Methods Using RT-qPCR, we studied the expression of Adhesion GPCRs in the esophagus, the corpus and antrum of the stomach, the proximal and distal parts of the duodenum, ileum, jejunum and colon, and the cecum. Results We found that twenty-one Adhesion GPCRs (70%) had a widespread (expressed in five or more segments) or ubiquitous (expressed in eleven or more segments) distribution, seven (23%) were restricted to a few segments of the GI tract and two were not expressed in any segment. Most notably, almost all Group III members were ubiquitously expressed, while the restricted expression was characteristic for the majority of group VII members, hinting at more specific/localized roles for some of these receptors. Conclusions Overall, the distribution of Adhesion GPCRs points to their important role in GI tract functioning and defines them as a potentially crucial target for pharmacological interventions.
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- 2012
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91. The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
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Lawson, Elizabeth A., primary, Olszewski, Pawel K., additional, Weller, Aron, additional, and Blevins, James E., additional
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- 2019
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92. Blunted hyperphagic and c-Fos immunoreactivity responsiveness to an orexigen, butorphanol tartrate, in aged rats
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Olszewski, Pawel K., primary, McColl, Laura K., additional, Herisson, Florence M., additional, Klockars, Anica, additional, and Levine, Allen S., additional
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- 2019
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93. Effect of Oxytocin on Hunger Discrimination
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Head, Mitchell A., primary, Jewett, David C., additional, Gartner, Sarah N., additional, Klockars, Anica, additional, Levine, Allen S., additional, and Olszewski, Pawel K., additional
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- 2019
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94. Palatability of Goat’s versus Cow’s Milk: Insights from the Analysis of Eating Behavior and Gene Expression in the Appetite-Relevant Brain Circuit in Laboratory Animal Models
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Klockars, Anica, primary, Wood, Erin, additional, Gartner, Sarah, additional, McColl, Laura, additional, Levine, Allen, additional, Carpenter, Elizabeth, additional, Prosser, Colin, additional, and Olszewski, Pawel, additional
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- 2019
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95. Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway
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Rask-Andersen Mathias, Almén Markus, Olausen Hans R, Olszewski Pawel K, Eriksson Jenny, Chavan Rohit A, Levine Allen S, Fredriksson Robert, and Schiöth Helgi B
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Abstract Background The Fat mass and obesity gene (FTO) has been identified through genome wide association studies as an important genetic factor contributing to a higher body mass index (BMI). However, the molecular context in which this effect is mediated has yet to be determined. We investigated the potential molecular network for FTO by analyzing co-expression and protein-protein interaction databases, Coxpresdb and IntAct, as well as the functional coupling predicting multi-source database, FunCoup. Hypothalamic expression of FTO-linked genes defined with this bioinformatics approach was subsequently studied using quantitative real time-PCR in mouse feeding models known to affect FTO expression. Results We identified several candidate genes for functional coupling to FTO through database studies and selected nine for further study in animal models. We observed hypothalamic expression of Profilin 2 (Pfn2), cAMP-dependent protein kinase catalytic subunit beta (Prkacb), Brain derived neurotrophic factor (Bdnf), neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2), Signal transducer and activator of transcription 3 (Stat3), and Btbd12 to be co-regulated in concert with Fto. Pfn2 and Prkacb have previously not been linked to feeding regulation. Conclusions Gene expression studies validate several candidates generated through database studies of possible FTO-interactors. We speculate about a wider functional role for FTO in the context of current and recent findings, such as in extracellular ligand-induced neuronal plasticity via NTRK2/BDNF, possibly via interaction with the transcription factor CCAAT/enhancer binding protein β (C/EBPβ).
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- 2011
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96. Parametric analysis of pumping station with parallel-configured centrifugal pumps towards self-learning applications
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Olszewski, Pawel, primary and Arafeh, Jamal, additional
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- 2018
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97. The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
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Levine Allen S, Sreedharan Smitha, Alsiö Johan, Cedernaes Jonathan, Olszewski Pawel K, Shaik Jafar HA, Jacobsson Josefin A, Almén Markus, Fredriksson Robert, Marcus Claude, and Schiöth Helgi B
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Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background TMEM18 is a hypothalamic gene that has recently been linked to obesity and BMI in genome wide association studies. However, the functional properties of TMEM18 are obscure. Methods The evolutionary history of TMEM18 was inferred using phylogenetic and bioinformatic methods. The gene's expression profile was investigated with real-time PCR in a panel of rat and mouse tissues and with immunohistochemistry in the mouse brain. Also, gene expression changes were analyzed in three feeding-related mouse models: food deprivation, reward and diet-induced increase in body weight. Finally, we genotyped 502 severely obese and 527 healthy Swedish children for two SNPs near TMEM18 (rs6548238 and rs756131). Results TMEM18 was found to be remarkably conserved and present in species that diverged from the human lineage over 1500 million years ago. The TMEM18 gene was widely expressed and detected in the majority of cells in all major brain regions, but was more abundant in neurons than other cell types. We found no significant changes in the hypothalamic and brainstem expression in the feeding-related mouse models. There was a strong association for two SNPs (rs6548238 and rs756131) of the TMEM18 locus with an increased risk for obesity (p = 0.001 and p = 0.002). Conclusion We conclude that TMEM18 is involved in both adult and childhood obesity. It is one of the most conserved human obesity genes and it is found in the majority of all brain sites, including the hypothalamus and the brain stem, but it is not regulated in these regions in classical energy homeostatic models.
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- 2010
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98. Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression
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Levine Allen S, Olszewski Pawel K, Shaik Jafar HA, Sreedharan Smitha, Schiöth Helgi B, and Fredriksson Robert
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Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background The SLC17 family of transporters transports the amino acids: glutamate and aspartate, and, as shown recently, also nucleotides. Vesicular glutamate transporters are found in distinct species, such as C. elegans, but the evolutionary origin of most of the genes in this family has been obscure. Results Our phylogenetic analysis shows that the SLC17 family consists of four main phylogenetic clades which were all present before the divergence of the insect lineage. One of these clades has not been previously described and it is not found in vertebrates. The clade containing Slc17a9 had the most restricted evolutionary history with only one member in most species. We detected expression of Slc17a1-17a4 only in the peripheral tissues but not in the CNS, while Slc17a5- Slc17a9 are highly expressed in both the CNS and periphery. Conclusions The in situ hybridization studies on vesicular nucleotide transporter revealed high expression throughout the cerebral cortex, certain areas in the hippocampus and in specific nuclei of the hypothalamus and thalamus. Some of the regions with high expression, such as the medial habenula and the dentate gyrus of the hippocampus, are important sites for purinergic neurotransmission. Noteworthy, other areas relying on purine-mediated signaling, such as the molecular layer of the dentate gyrus and the periaqueductal gray, lack or have a very low expression of Slc17a9, suggesting that there could be another nucleotide transporter in these regions.
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- 2010
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99. Effect of nociceptin/orphanin FQ on food intake in rats that differ in diet preference
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Olszewski, Pawel K, Grace, Martha K, Sanders, Jeffrey B, Billington, Charles J, and Levine, Allen S
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- 2002
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100. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
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Radomska Katarzyna J, Alsiö Johan, Stephansson Olga, Olszewska Agnieszka M, Fredriksson Robert, Olszewski Pawel K, Levine Allen S, and Schiöth Helgi B
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Abstract Background Polymorphism in the FTO gene is strongly associated with obesity, but little is known about the molecular bases of this relationship. We investigated whether hypothalamic FTO is involved in energy-dependent overconsumption of food. We determined FTO mRNA levels in rodent models of short- and long-term intake of palatable fat or sugar, deprivation, diet-induced increase in body weight, baseline preference for fat versus sugar as well as in same-weight animals differing in the inherent propensity to eat calories especially upon availability of diverse diets, using quantitative PCR. FTO gene expression was also studied in organotypic hypothalamic cultures treated with anorexigenic amino acid, leucine. In situ hybridization (ISH) was utilized to study FTO signal in reward- and hunger-related sites, colocalization with anorexigenic oxytocin, and c-Fos immunoreactivity in FTO cells at initiation and termination of a meal. Results Deprivation upregulated FTO mRNA, while leucine downregulated it. Consumption of palatable diets or macronutrient preference did not affect FTO expression. However, the propensity to ingest more energy without an effect on body weight was associated with lower FTO mRNA levels. We found that 4-fold higher number of FTO cells displayed c-Fos at meal termination as compared to initiation in the paraventricular and arcuate nuclei of re-fed mice. Moreover, ISH showed that FTO is present mainly in hunger-related sites and it shows a high degree of colocalization with anorexigenic oxytocin. Conclusion We conclude that FTO mRNA is present mainly in sites related to hunger/satiation control; changes in hypothalamic FTO expression are associated with cues related to energy intake rather than feeding reward. In line with that, neurons involved in feeding termination express FTO. Interestingly, baseline FTO expression appears linked not only with energy intake but also energy metabolism.
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- 2009
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