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Purpose The purpose of this paper is to apply the Steady State Kalman Filter for temperature measurements of tissues via magnetic resonance thermometry. Instead of using classical direct inversion, a methodology is proposed that couples the magnetic resonance thermometry with the bioheat transfer problem and the local temperatures can be identified through the solution of a state estimation problem.Design/methodology/approach Heat transfer in the tissues is given by Pennes’ bioheat transfer model, while the Proton Resonance Frequency (PRF)-Shift technique is used for the magnetic resonance thermometry. The problem of measuring the transient temperature field of tissues is recast as a state estimation problem and is solved through the Steady-State Kalman filter. Noisy synthetic measurements are used for testing the proposed methodology.Findings The proposed approach is more accurate for recovering the local transient temperatures from the noisy PRF-Shift measurements than the direct data inversion. The methodology used here can be applied in real time due to the reduced computational cost. Idealized test cases are examined that include the actual geometry of a forearm.Research limitations/implications The solution of the state estimation problem recovers the temperature variations in the region more accurately than the direct inversion. Besides that, the estimation of the temperature field in the region was possible with the solution of the state estimation problem via the Steady-State Kalman filter, but not with the direct inversion.Practical implications The recursive equations of the Steady-State Kalman filter can be calculated in computational times smaller than the supposed physical times, thus demonstrating that the present approach can be used for real-time applications, such as in control of the heating source in the hyperthermia treatment of cancer.Originality/value The original and novel contributions of the manuscript include: formulation of the PRF-Shift thermometry as a state estimation problem, which results in reduced uncertainties of the temperature variation as compared to the classical direct inversion; estimation of the actual temperature in the region with the solution of the state estimation problem, which is not possible with the direct inversion that is limited to the identification of the temperature variation; solution of the state estimation problem with the Steady-State Kalman filter, which allows for fast computations and real-time calculations. [ABSTRACT FROM AUTHOR]

Purpose This paper aims to present development and application of the Bayesian inverse approach for retrieving parameters of non-linear diffusion coefficient based on the integral information.Design/methodology/approach The Bayes formula was used to construct posterior distribution of the unknown parameters of non-linear diffusion coefficient. The resulting aposteriori distribution of sought parameters was integrated using Markov Chain Monte Carlo method to obtain expected values of estimated diffusivity parameters as well as their confidence intervals. Unsteady non-linear diffusion equation was discretised with the Global Radial Basis Function Collocation method and solved in time using Crank–Nicholson technique.Findings A number of manufactured analytical solutions of the non-linear diffusion problem was used to verify accuracy of the developed inverse approach. Reasonably good agreement, even for highly correlated parameters, was obtained. Therefore, the technique was used to compute concentration dependent diffusion coefficient of water in paper.Originality/value An original inverse technique, which couples efficiently meshless solution of the diffusion problem with the Bayesian inverse methodology, is presented in the paper. This methodology was extensively verified and applied to the real-life problem. [ABSTRACT FROM AUTHOR]

Purpose The purpose of this paper is to focus on applications related to the hyperthermia treatment of cancer, with heating imposed either by a laser in the near-infrared range or by radiofrequency waves. The particle filter algorithms are compared in terms of computational time and solution accuracy.Design/methodology/approach The authors extend the analyses performed in their previous works to compare three different algorithms of the particle filter, as applied to the hyperthermia treatment of cancer. The particle filters examined here are the sampling importance resampling (SIR) algorithm, the auxiliary sampling importance resampling (ASIR) algorithm and Liu & West’s algorithm.Findings Liu & West’s algorithm resulted in the largest computational times. On the other hand, this filter was shown to be capable of dealing with very large uncertainties. In fact, besides the uncertainties in the model parameters, Gaussian noises, similar to those used for the SIR and ASIR filters, were added to the evolution models for the application of Liu & West’s filter. For the three filters, the estimated temperatures were in excellent agreement with the exact ones.Practical implications This work may help medical doctors in the future to prescribe treatment protocols and also opens the possibility of devising control strategies for the hyperthermia treatment of cancer.Originality/value The natural solution to couple the uncertain results from numerical simulations with the measurements that contain uncertainties, aiming at the better prediction of the temperature field of the tissues inside the body, is to formulate the problem in terms of state estimation, as performed in this work. [ABSTRACT FROM AUTHOR]