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1,080 results on '"Otsuki, Makoto"'

60. Supramaximal CCK and CCh concentrations abolish VIP potentiation by inhibiting adenylyl cyclase activity

Author

Akiyama, Toshiharu, Hirohata, Yoshihide, Okabayashi, Yoshinori, Imoto, Issei, and Otsuki, Makoto

Subjects
Adenylate cyclase -- Physiological aspects, Cholecystokinin -- Physiological aspects, Pancreas -- Physiological aspects, Peptides -- Physiological aspects, Protein kinases -- Physiological aspects, Biological sciences
Abstract

The mechanisms by which supramaximal concentrations of cholecystokinin octapeptide (CCK-8) or carbachol decrease the vasoactive intestinal polypeptide (VIP)-induced potentiation of amylase secretion from isolated rat pancreatic acini were investigated. Findings showed that supramaximal concentrations of CCK-8 and carbachol decrease the potentiating effect of VIP and forskolin on amylase secretion by restricting the adenylyl activity. also, protein kinase C may be partly responsible for this inhibitory mechanism.

Published
1998

74. CCK-, secretin-, and cholinergic-independent pancreatic fluid hypersecretion in protease inhibitor-treated rats

Author

Yamamoto, Mitsuyoshi, Shirohara, Hisashi, and Otsuki, Makoto

Subjects
Exocrine glands -- Secretions, Pancreas -- Physiological aspects, Biological sciences
Abstract

The mechanism responsible for the hypersecretion of pancreatic fluid in rats treated with a synthetic oral protease inhibitor is investigated. The secretory response was independent of cholecystokinin, secretin and cholinergic activities. Experiments using labeled nucleotides reveal enhanced proliferation of acinar cells. Therefore, the observed increase in pancreatic secretion may be explained by an increase in the number of acinar cells.

Published
1998

90. Defect in pancreatic exocrine and endocrine repsonse to CCK in genetically diabetic OLETF rats

Author

Tachibana, Issei, Akiyama, Toshiharu, Kanagawa, Kennji, Shirohara, Hisashi, Furumi, Katsuhiko, Watanabe, Nobuaki, and Otsuki, Makoto

Subjects
Pancreatic diseases -- Research, cholecystokinin -- Physiological aspects, Diabetes -- Physiological aspects, Biological sciences
Abstract

The genetically diabetic Otsuka Long-Evans Takashima fatty (OLETF) rats are not responsive to either endogenous or exogenous cholecystokinin (CCK) stimulation of their pancreatic exocrine systems. Infusions of CCK-8 on OLETF rats did not effect their pancreatic juice and protein secretion. However, intravenous infusions of CCK-8 did elevate gastric acid secretion in these rats.

Published
1996

96. Abstracts of selected papers presented at the 32nd Annual Meeting of the Japanese Society of Gastroenterology

Author

Sata, Naohiro, Atomi, Yutaka, Ohshio, Gakuji, Manabe, Tadao, Watanabe, Shin-ichiro, Takeuchi, Tadashi, Miyasaka, Kyoko, Funakoshi, Akihiro, Hayakawa, Tetsuo, Nagai, Kenji, Murata, Atsuo, Ogawa, Michio, Takeda, Kazunori, Matsuno, Seiki, Tomiya, Tomoaki, Fujiwara, Kenji, Nakamura, Toshio, Nakanishi, Toshio, Sasaki, Iwao, Matsuno, Seiki, Yoshino, Keiichi, Makuuchi, Hiroyasu, Sawaguchi, Yuji, Uchino, Junichi, Yokoi, Hajime, Kawarada, Yoshifumi, Komatsu, Hirokazu, Oda, Masaya, Komada, Toshiyuki, Kitami, Noriyuki, Sato, Nobuhiro, Inada, Masami, Kawata, Sumio, Koga, Michiaki, Yano, Michitami, Takano, Susumu, Omata, Masao, Yasunaga, Mitsuru, Shirasawa, Hiroyuki, Ouchi, Kiyoaki, Matsuno, Seiki, ASakura, Hitoshi, Okabe, Nobuo, Yao, Tsuneyoshi, Bamba, Tadao, Fujiyama, Yoshihide, Okawa, Kiyotaka, Harihara, Shigeyoshi, Ohkusa, Toshifumi, Sasabe, Masataka, Shoji, Yasutsugu, Utsunomiya, Joji, Hayashi, S., Furukawa, T., Matsuhashi, Nobuyuki, Sugano, Kentaro, Yamazaki, Hideo, Hiwatashi, Nobuo, Ashida, Tomofumi, Ayabe, Tokiyoshi, Takazoe, Masakazu, Inoue, Noboru, Kitano, A., Kobayashi, K., Fukuda, Yoshihiro, Tamura, Kazutami, Koyama, Hiroshi, Niwa, Hirohumi, Takahashi, Shuji, Yoshikawa, Toshikazu, Mizuno, Shiuichi, Sasaki, Ei, Toyonaga, Atsushi, Okabayashi, Yoshinori, Otsuki, Makoto, Shiratori, Keiko, Watanabe, Shin-ichiro, Ozawa, Susumu, Tanaka, Shigeki, Funakoshi, Akihiro, Wakasugi, Hideyuki, Tazawa, Yusaku, Takikawa, Hajime, Kawasaki, Hironaka, Tanaka, Naomi, Kajiyama, Goro, Shimoyama, Takashi, and Kanazawa, Kyotaro

Published
1992
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97. Abstracts of Selected Papers Presented at the 76th General Meeting of the Japanese Society of Gastroenterology

Author

Watanabe, Yasuyuki, Nakanishi, Toshi, Mori, Yoshio, Oto, Masao, Onji, Morikazu, Ohta, Yasuyuki, Kuroki, Tetsuo, Yamamoto, Sukeo, Iwasaki, Yoshiaki, Tsuji, Takao, Ikeda, Yusei, Toda, Gotaro, Saitoh, T., Asakura, H., Onishi, Saburo, Iwasaki, Shinji, Oda, M., Azuma, T., Ikeda, Takaaki, Hasumura, Yasushi, Usui, K., Ishii, H., Nakano, Hitoshi, Tanikawa, Kyuichi, Inoue, Kyoichi, Higuchi, Kiyohiro, Hasumura, Satoshi, Nagamori, Scishi, Okanoue, Takeshi, Morimoto, Michio, Koide, Norio, Tsuji, Takao, Hayashi, Norio, Sato, Nobuhiro, Ono, Shigeki, Moriyasu, Fuminori, Miyazaki, Kohji, Hisatsugu, Takeharu, Kawamura, Yasuhito, Nakanuma, Yasuni, Tarao, Kazuo, Shimizu, Akio, Nishida, Jiro, Oda, Masaya, Okabayashi, Yoshinori, Otsuki, Makoto, Hosotani, Ryo, Tobe, Takayoshi, Sumii, Kimura, Toshinari, Mutoh, Hiroyuki, Terano, Akira, Terashima, H., Yabana, T., Yakabe, Koji, Nakamura, Takashi, Yamada, Tadataka, Chiba, T., Fujita, T., Ikeda, Yoshitake, Kitajima, Masaki, Nakajo, Shinobu, Minemori, Kiyoharu, Nakanishi, Takashi, and Okuno, Masaru

Published
1992
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99. Loss of sensitivity to cholecystokinin stimulation of isolated pancreatic acini from genetically diabetic rats

Author

Otsuki, Makoto, Akiyama, Toshiharu, Shirohara, Hisashi, Nakano, Shigekazu, Furumi, Katsuhiko, and Tachibana, Issei

Subjects
cholecystokinin -- Research, Amylases -- Physiological aspects, Islands of Langerhans -- Research, Biological sciences
Abstract

Pancraeatic exocrine function of inbred Otsuka-Long-Evans Jokushima Fatly (OLETF) rat is evaluated in in vitro isolated panereatic acini and comparitively evaluated in control Long-Evans Jokushima Otsuka (LETO) rat. The rats exhibited a very high level of glucose, resum and insulin concentrations. The inbred OLETF rats have a selective defect in binding of CCK to the receptors on their acinar cell surface.

Published
1995

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