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The present study was performed to investigate the role of p38 mitogen‑activated protein kinase (MAPK) in the resorption of herniated intervertebral discs in 30 rats. In the non‑contained and p38 MAPK inhibition (p38i) groups, two coccygeal intervertebral discs (IVDs) were removed and wounded prior to relocation into the subcutaneous space of the skin of the back. In the contained group, the cartilage endplates maintained their integrity. Furthermore, SB203580 was injected intraperitoneally into the p38i group, whereas saline was injected into the other two groups. In the non‑contained group, the weight of the relocated IVDs decreased to a greater extent over time when compared with the contained and p38i groups. Phosphorylated p38, tumor necrosis factor‑α, and interleukin‑1β were observed to exhibit higher expression levels in the non‑contained group compared with the contained and p38i groups, at weeks 1 and 4 post‑surgery. The expression level of caspase‑3 and the densities of apoptotic disc cells were significantly higher in the non‑contained group compared with the contained and p38i groups at 4 weeks post‑surgery. In conclusion, p38 MAPK induces apoptosis in IVDs, while also accelerating the resorption of the relocated IVDs. Thus, p38 MAPK may be important in spontaneous resorption of IVDs.

To investigate the outcome predictive factors of ruptured lumbar disc herniation after conservative treatment.From June 2009 to June 2016, 147 patients with ruptured lumbar intervertebral disc herniation were treated with conservative treatment in the orthopedics department of Suzhou Traditional Chinese Medicine Hospital for clinical efficacy and MRI follow-up. Multivariate Logistic regression analysis(Stepwise regression method)was used to analyze the relationship between the 11 categorical variables and absorptivity of protrusions: sex(X1), age(X2), course of disease(X3) , the rate of protrusion(X4), the Komori type(X5), the MSU type(X6), the Iwabuchi type(X7), the Pfirrmann grade(X8), the Modic change on adjacent vertebrae(X9), spinal canal morphology(X10), the Schizas types of cauda equina sedimentation sign(X11).A total of 64 cases of prominent reabsorption among all cases followed-up (absorption rate=30%), accounting for 43.5%. The reabsorption of protrusions is more likely to occur in patients with a duration of less than 1 year(Ruptured lumbar disc herniation can be reabsorbed after nonoperative treatment. And the reabsorption of protrusions is more likely to occur in patients with a duration of less than 1 year, MSU type 3, Iwabuchi type 1 or 5, the Schizas type of cauda equina sedimentation sign A or B, which can be used as the key reference factors for predicting the outcome of the projections.

To investigate clinical effect of percutaneous reduction and Kirschner pin flxation through sinus tarsi approach in treating Sanders type III calcaneal fracture.Totally 22 patients (22 feet) with Sanders III calcaneal fracture were treated with percutaneous reduction and Kirschner pin flxation through sinus tarsi approach form September 2013 to December 2015. Among them, including 18 males and 4 females; aged from 20 to 65 years old with an average of (41.73±12.46) years old. Böhler angle, Gissane angle and calcaneal width before and after operation were observed and compared, Maryland scoring system was used to evaluate curative effect; postoperative complications were recorded.All patients were followed up from 18 to 36 months with an average of (27.05±4.92) months. All fractures healed well with an average of (10.73±1.24) weeks. Böhler angle before operation (11.36±5.92) improved to (33.36±3.99) after operation, and had significant differences(Compared with conventional internal fixation through L-shape incision, percutaneous reduction and Kirschner pin flxation through sinus tarsi approach in treating Sanders type III calcaneal fracture obtained satisfied clinical effects, and has advantages of invasive trauma, simple operation, easy to remove and less complication. Meanwhile, careful operation and identification should be done during sinus tarsi approach operation to protect sural nerve and tendon.

This research adopts the important iron electrolysis, removal of the wastewater of high COD, SS, phosphorus pretreatment experiment. Discusses the different iron dosing quantity, iron carbon ratio, and pH value, reaction time on the COD and turbidity, the influence of the phosphorus removal effect. Studies show that iron important electrochemical test in brewery wastewater treatment static optimal processing conditions for: water pH value is 4, 5% dosage of iron filings, 60 min temperature response, COD removal rate was 52.31%. When the iron carbon ratio of 2:1, removing effect is good, can reach 54.53%.

For software function verification and performance testing, a test platform was built during the development of large-capacity EPON OLT equipment. The platform was based on distributed system,which using modified TCP/UDP to establish RPC data exchange path between nodes. With Linux as unified operating system, software work in both embedded PowerPC and x86-based PC virtual machines without modification. At last, a group of stress test was executed on the platform and the result was discussed.

Xing-Hui Shao,1 Yan-Min Yang,1 Jun Zhu,1 Han Zhang,1 Yao Liu,1 Xin Gao,1 Li-Tian Yu,1 Li-Sheng Liu,1 Li Zhao,2 Peng-Fei Yu,3 Hua Zhang,4 Qing He,5 Xiao-Dan Gu6 1Emergency and Intensive Care Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 2Department of Emergency, Fu Xing Hospital, Capital Medical University, Beijing, 3Department of Cardiology, Pingdu People’s Hospital, Pingdu, 4Department of Emergency, Qingdao Municipal Hospital, Qingdao, 5Department of Emergency, West China Hospital, Sichuan University, Chengdu, 6Department of Emergency, Sixth People’s Hospital of Chengdu, Chengdu, People’s Republic of China Background: Atrial fibrillation (AF) disproportionately affects older adults. However, direct comparison of clinical features, medical therapy, and outcomes in AF patients aged 65–74 and ≥75 years is rare. The objective of the present study was to evaluate the differences in clinical characteristics and prognosis in these two age-groups of geriatric patients with AF.Materials and methods: A total of 1,336 individuals aged ≥65 years from a Chinese AF registry were assessed in the present study: 570 were in the 65- to 74-year group, and 766 were in the ≥75-year group. Multivariable Cox hazards regression was performed to analyze the major adverse cardiac events (MACEs) between groups.Results: In our population, the older group were more likely to have coronary artery disease, hypertension, previous stroke, cognitive disorder, or chronic obstructive pulmonary disease, and the 65- to 74-year group were more likely to have valvular heart disease, left ventricular systolic dysfunction, or sleep apnea. The older patients had 1.2-fold higher mean CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke) scores, but less ­probability of being prescribed drugs. Compared with those aged 65–74 years, the older group had a higher risk of death (hazard ratio 2.881, 95% confidence interval 1.981–4.189; P

Objective To explore the therapeutic effects of a traditional Chinese medicine (TCM) regimen on patients with ruptured lumbar disc herniation, including assessing its effects on prognosis and protrusion size. Methods From June 2008 to December 2011, 102 patients with ruptured lumbar disc herniation who chose conservative treatment with TCM as their first choice were followed up for 2 years to assess their final surgical rate, improvement according to Japanese Orthopaedic Association (JOA) scores, and to calculate the volume and rate of resorption of their protrusions by magnetic resonance imaging (MRI). Results (i) Eighty-three of the 102 patients (81.37%) experienced partial or complete relief; the remaining 19 (18.63%) eventually needed surgery. (ii) In the 83 patents who underwent conservative treatment, rates of excellent JOA scores at 3 months, 6 months, 1 year and 2 years were 79.52%, 81.93%, 81.93% and 83.13% respectively; differences between these and pretreatment scores are all statistically significant (P 50%. The remaining 63 patients had no obvious resorption; their excellent rate was 77.77%. The difference in rate of achieving an excellent outcome differed significantly between those who did and did not have resorption of their protrusions (P = 0.018). Conclusion Conservative treatment with a TCM regimen is effective for ruptured lumbar disc herniation and can promote resorption of the protrusion; however, patients who develop specific indications for surgery during such treatment should undergo surgery in a timely manner.

In this study a food company in the production of sauerkraut pickled wastewater as an object, using the anaerobic biological filter and biological contact oxidation pond process, feed water salinity, HRT are investigated, and the effects of each process. The results showed that anaerobic biological filter when HRT is 36 h, the COD removal rate can reach 81%. Biological contact oxidation pool when HRT is 60 h, when the COD removal rate reached 85%. Anaerobic biological filter - biological contact oxidation coupling process of pickling wastewater removal effect is obvious, after processing salted COD removal rate reached 88%.

Constructing the network experimental platform is one of the effective assessment methods of digital substation communication network. It is introduced in great detail that “Common Network and Shared Port” is the special feature of intelligent substation communication network nowadays. It is a simulation technology based on the network experimental platform and sum up some credible, quantitative and accurate methods. Because they are need to adapt to the development of the digital substation communication network. Specially, the situation of different network architectures and the unpredictable performance have been changed in the near future. As a new generation of intelligent substation communication, this method can provide strong support for network constructions.

Ethernet ring networks are used widely recently, and the research on the ring protection switching is carried out. Spanning Tree Protocol (STP) was the first technology to control ring networks to avoid the storm. Rapid Spanning Tree Protocol (RSTP) is an upgraded version of STP[1]. RSTP can provide shorter convergence time than STP. Ethernet Automatic Protection switching (EAPS) is designed for a single ring topology [2]. The convergence time of EAPS is below 50ms and EAPS can meet the real-time requirements and high-reliability requirements of network services.G.8032 is a standardized scheme for achieving sub-50ms service protection in ring topologies which is recommended by ITU-T[3]. This paper intelligent Ethernet ring protection technologes about Spanning Tree Protocol, RFC3619 and G.8032 .These technologies appear in different times, and have their advantages and disadvantages. This article outlines these Ethernet ring protection switching technology and explains their basal principles.

To solve the problem of high-salt ballast wastewater treatment, biological contact oxidation process by combined packing used to simulate the experimental study. When dissolved oxygen is 5 to 6, water temperature is 18 ~ 20 °C, pH is 7~8 and hydraulic retention time is 48h, the Influence of salinity dips and swells process on sludge treatment system and its effects were investigated. The results showed that salinity shock loads on the system less affected COD removal, after 3-5 days short adaptability run, the system became able to restore effluent water stability. The influence of Salinity swells process on AOB, NOB and denitrifying bacteria was greater than a dip .Salinity plunged produced smaller impact on the total nitrogen removal, while in the salinity swells TN removal reduced from 70.7% to 42%.

To facilitate investigation of the effect of imperfect elastic dissipation on the propagation of Rayleigh-type channel waves and use of their quality factors in investigations of the properties of coal seams, a simple method for calculating the quality factor QR is proposed in this paper. Introduction of complex velocities into the dispersion function allows calculation of the dispersion function of Rayleigh-type channel waves in coal seams. By the control variable method, we analyzed changes in QR with changes in coal seam thickness and P- and S-wave Q-factors within the coal seam and adjacent rock layers. The numerical results show that the trend of the QR curve is consistent with the group velocity curve. The minimum QR value occurs at the Airy phase frequency; the Airy phase frequency decreases as coal seam thickness increases. The value of QR increases with increasing QS2 (quality factor for S wave in coal seam). We can compensate for the absorption of Rayleigh-type channel waves using the computed QR curve. Inversion of the QR curve can also be used to predict the thicknesses and lithologies of coal seams.

This paper describes the content and process of comprehensive testing the TOPCON NET-G3A GNSS receivers, which includes five parts, such as general performance testing and internal noise level testing of receiver, stability testing of Antenna phase center, TEQC testing and repetition rate testing of long baseline of receivers. Meanwhile, data of GNSS receiver testing is calculated and analyzed. The testing results show that TOPCON NET-G3A receiver is a high-precision GNSS receiver and fully meets the requirements for the GNSS precision measurement.

Over the last ten years, considerable progress has been made on the new hand-based biometric recognition, such as palmprint and hand vein. During this period, it has been proved that Finger-Knuckle-Print (FKP) can be used as a biometric identifier. In this paper, we present an effective FKP identification method based on Local Binary Pattern (LBP), whose idea is to divide the region of interest (ROI) of FKP into a set of sub-image blocks, which can be applied to extract the local features of the FKP. After that, LBP histograms of image blocks in a FKP ROI image are connected together to build the feature vector of the FKP ROI image. In the match stage, histogram intersection distance is applied as the similarity measurement between sample and template. Experimental results conducted on a database of 165 persons (4 fingers per person) show that the proposed method is effective.

With the rapid development of biometric technology, the security issues have drawn people's greater attention because some biometric features are Easy to forge and are not replaceable. As a result, the security issue of biometric system extremely critical to be solved. In this paper, we introduce a public watermarking algorithm which is based on Discrete Cosine Transformation (DCT). By using the proposed algorithm, the finger geometry is embedded into the region of interest (ROI) of palmprint image. This method has the ability to increase the security of both the palmprint image and the finger geometry. Experimental results performed on a database of 86 hands (10 impressions per hand) show that the proposed algorithm is effective, and the watermarking operation has little impact on the recognition performance.

TU-T has recommended a standardized scheme for achieving sub-50ms service protection in ring topologies through Ethernet Ring Protection Switching (ERPS) specified in G.8032 recommendation[. ERPS provides a means to reliably achieve carrier-class network requirements for Ethernet topologies forming a closed loop. This article outlines an Ethernet ring protection switching mechanism and explains how its automatic protection switching (APS) protocol works. In addition, this article illustrates a sample scenario with failure and recovery.

A new synthetic pilot pressure positive flow control system used in excavator was proposed in this paper, The mathematical models of this system and the positive control system were established, the transfer functions from the displacements of the regulating pressure springs to the operating cylinder piston, and the rotational angle of the right walking motor were deduced. The output power curves of these two control systems were acquired using AMEsim. The simulation results show that the synthesis pilot pressure positive flow control system is more stable and has higher power utilization rate to the traditional positive control system used in excavator. The new control system provides an new design method of energy-saving excavator control system.

With the development of smart power grid technology, EPON has become a popular communications technology both in power distribution and utilization automation. The article analyses several communication path protection methods of EPON system, then introduces the development of a dual PON-MAC ONU for such application, both hardware and software design are discussed. At last, A group of test data which verify the performance of fast protect switchover is given..

The LiFePO4/C cathode material was synthesized by two–step addition of dual carbon sources method based on the in situ polymerization method combining with two–step sintering process. In this study, the structure and morphology have been studied systematically by X–ray diffraction (XRD) and scanning electron microscope (SEM).The electrochemical performances have been shown by the charge/discharge capacity, rate property, cycle performance. It was evidenced that the two–step addition of dual carbon sources had remarkable advantages, including the more complete coating carbon, and the improvement in the electrochemical performance of LiFePO4/C.

Olivine structured LiFePO4 are prepared by sol-gel method from FePO4·H2O nanocrystallites, which are synthesized via in situ polymerization restriction technique. These composites are fully characterized using XRD, SEM, and the electrochemical performances have been shown by the charge/discharge capacity, rate property and cycle performance. The synthesized LiFePO4 samples show well-crystallized structures. Among those samples, the sample synthesized at 650°C presents the highest discharge capacity of 165.8 mAhg-1 at 0.2 C. This compares with a theoretical discharge capacity of 170 mAhg-1.

In the "12th Five-Year Plan" period, government will continue to promote the construction of Intelligent Electric Grid , and the construction of more efficient electric power communication access network will also go into the extensive stage from partial stage. But as so far, a large number of public network devices are applied in power communication system, so the equipment’s security is one important issue. This paper analyze the situation of electric power communication access network firstly, and then introduce our specific work in some one device’s security, such as user authentication protocol, the hand-in-hand protection of EPON, and devices’ EMC.

AC-AC Cuk Converter which constituted by bidirectional switch has an advantage of high transmission efficiency, but most of them usually use open-loop control. In this paper, we propose one-cycle control of the AC-AC Cuk converter. The operating principle and control method are presented. The simulation results based on Matlab are given to verify its rationality and feasibility. Compared to common PID control, it has excellent control performance. Furthermore, one-cycle controlled AC-AC Cuk converter has the ability to reject input voltage perturbations and faster dynamic response.

Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population.We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry.After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk (P0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium.Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed.

In addition to the accelerating voltage of ions, ion charge state, ion sputtering, diffusion and phase change will all affect the concentration depth distribution. In order to distinguish the influence degree of the various factors, appropriate computational and experimental approaches must be put forward. Molybdenum ions from a metal vapor vacuum arc (MEVVA) ion source are implanted into aluminum to investigate the influence factors of the concentration depth profiles. The results of high voltage electron microscopy (HVEM) have showed that phase change are not induced by molybdenum ion implantation of an average current density of lower than 20μA/cm2. Rutherford backscattering spectroscopy (RBS) is used to investigate the Mo concentration depth profile in the Mo-implanted Al. RBS from Mo-implanted Al is converted to Mo concentration depth distribution considering the change of stopping cross section induced by high dose ion implantation. The measured concentration depth profile is compared with the calculation result of the TRIDYN program, in which sputtering and multi-charged state can both be considered dynamically. The deviation of the experiment and simulation results could be attributed to radiation enhanced diffusion or intense pulse beam current density implantation.

Microorganism endangers human health and safety. Traditional microbiology detector has problems of long detection period, indistinct judgment standard, and etc. A turbidimetry based rapid microbiology detector is designed in this paper. The detector is mainly composed of drawer typed chest with slide rail of wheel train, auto in-and-out device of centric slider-crank mechanism, and ultraviolet disinfection device. Such design is recommended for microbial detection where time, operation convenience and reliability of analytical techniques are of importance.

This paper studies the impact of cooling and warming on shortcut and simultaneous nitrification and denitrification under low temperature. The results show that the effluent concentration of NH4+-N and TN gradually increased, the nitrite accumulation rate decreased when DO was 0.3~0.5 mg•L-1, sludge return ratio was 300%, PH was 7.5~8.5, temperature dropped from 15 °Cto 8°C. From 10°C to 8°C in cooling, the average nitrite accumulation rate was 58.17% in A (HRT=24h) reactor. During the system heating process, treatment effect of the system gradually changed for the better. From 12°C to 15°Cin heating process, the average nitrite accumulation rate was 74.39% in B (HRT=48h) reactor. The system treatment effect in B reactor was better by contrasting A and B reactors, therefore, we can increase HRT to reduce the adverse effects on the system due to the temperature decreases to enhance TN removal effect of system.

The effects of temperature on electricity performance and microbial activity were investigated in single-chamber microbial fuel cell with proton exchange membrane (S-PEM-MFC) using glucose as substrate with phosphate buffer solution(PBS). The results showed that S-PEM-MFC able to adapt to a wide temperature range of 11, 18, 25, 30 and 35°C. The open circuit voltage, polarization, power density and microbial activity of S-PEM-MFC were increased with increasing temperature from 11 to 30°C. The maximum power density were 193.8mW∙m-3 at 30°C. Compared to 30°C, the battery open circuit voltage increased by only 4.8% at 35°C, while the polarization and power density is almost the same. These results demonstrate that according to the principle of economy which 30°C should be the optimal operating temperature of S-PEM-MFC.

Micron-scale Te-rich particles presented in CdZnTe crystals were directly observed using infrared transmission microscopy(IRTM).The generation of various Te-rich particles was discussed in conjunction with the growth conditions.In order to evaluate the impurities and defects behaviors,and to examine the crystalline quality,photoluminescence(PL) spectra were obtained at 10 K.The corresponding resistivity was evaluated simultaneously.The correlation between different shaped Te-rich particles in CdZnTe crystals and the corresponding PL spectra at 10 K was concluded compared with the characterized photo-peak in PL spectra.Well-defined sphere,hexagonal and triangular shaped incoherent Te-rich particles were generally presented in CdZnTe crystals grown from the charge with excess Te,which the(D0,X) peak usually dominated in the PL spectra.Cross-shaped Te-rich particles were found in CdZnTe crystals grown under stoichiometric condition where the DAP peak dominated in the PL spectra.Star-shaped Te-rich particles were normally obtained in CdZnTe crystals under Cd-rich conditions where the FWHM of(D0,X) peak was wide.

We have prepared CuO-based structures including Au/CuO/Pt and Au/CuO/Cu/Pt films and studied the memristive characteristics of the two samples. Current-voltage curves of the samples suggest that both CuO-based films are typical memristive devices, showing conventional pinched hysteresis loops. Furthermore, the presented Au/CuO/Cu/Pt structure with a seed Cu layer between CuO and bottom electrodes Pt demonstrates more typical memristive and better retention characteristics than Au/CuO/Pt. In order to explore the conducting mechanism for improved memristive properties, the electric transport characteristics of the device are analyzed using a space charge limited current and charge trap defect theory.

The redundant optical link protection is the most popular technology by which we advance the reliability of Ethernet Passive Optical Networking (EPON) in power communication network, and self-healing sooner the network better. Through optical link state monitoring technology, we can start the protection switching immediately. Through optical network unit(ONU) pre-registration technology, we can shorten the self-healing time. Moreover, everything is occur on ONU, and then it would simplify the process.

We investigate quantum teleportation using the entangled channel consisting of a two-qubit Heisenberg X Y Z model with a nonuniform magnetic field in the presence of phase decoherence. It is shown that the initial state of the channel plays an important role in the fully entangled fraction and the average fidelity of teleportation. The distinct feature of our teleportation scheme is that when the initial system is in the state | Ψ 〉 = m 2 | 01 〉 + n 2 | 10 〉 , the corresponding average fidelity is always larger than 2 / 3 even if there exist phase decoherence effects. Moreover, under certain circumstance, the average teleportation fidelity can be optimized by adjusting the magnitude of the nonuniform magnetic field.

Voltammetric response of calcium dobesilate (calcium 2,5-dihydroxybenzene sulfonate, CD) was observably enhanced at lanthanum hydroxide nanowire (LNW) modified carbon paste electrode. The enhancement action was characterized by both the increase of peak current and the reduction of peak potential separation of a pair of the redox peaks of CD, which resulted from both the increase of efficient surface area of the modified electrode and the chemical interaction of LNW with CD. With the sensitive oxidation peak of CD at the LNW/CPE, a linear sweep voltammetric method for the determination of CD was proposed. A linear range of 3.0×10−10−1.0×10−8 mol·L−1 was obtained along with a detection limit of 5×10−11 mol·L−1.

A sensing system for uracil was constituted by using lanthanum hydroxide nanowires (LNW) as a modifier to obtain LNW modified carbon paste electrode (LNW/CPE) and by introducing copper(II) ion into supporting electrolyte to transform electroinactive uracil to electroactive uracil‐Cu(II) complex. The voltammetric behaviors of uracil in the presence of Cu(II) ion at LNW/CPE were investigated. A reduction peak of the uracil‐Cu(II) complex at −0.18 V was the two‐electron reduction of Cu(II) ion in the uracil‐Cu(II) complex; while a new oxidation peak at 0.22 V was the one‐electron oxidation of the uracil‐Cu(I) complex. Additionally, the voltammetric responses of all the complexes at LNW/CPE were more sensitive than that at carbon and multiwall carbon nanotube paste electrodes, which resulted from both the large surface effect of LNW and the chemical coordination of uracil with La(III) ion in LNW. With the sensitive oxidation peak of the uracil‐Cu(I) complex at LNW/CPE, a linear range of 4.0×10−9−3.0×...

A novel voltammetric method for the determination of beta-d-glucose (GO) is proposed based on the reduction of Cu(II) ion in Cu(II)(NH(3))(4)(2+)-GO complex at lanthanum(III) hydroxide nanowires (LNWs) modified carbon paste electrode (LNWs/CPE). In 0.1mol L(-1) NH(3).H(2)O-NH(4)Cl (pH 9.8) buffer containing 5.0x10(-5)mol L(-1) Cu(II) ion, the sensitive reduction peak of Cu(II)(NH(3))(4)(2+)-GO complex was observed at -0.17V (versus, SCE), which was mainly ascribed to both the increase of efficient electrode surface and the selective coordination of La(III) in LNW to GO. The increment of peak current obtained by deducting the reduction peak current of the Cu(II) ion from that of the Cu(II)(NH(3))(4)(2+)-GO complex was rectilinear with GO concentration in the range of 8.0x10(-7) to 2.0x10(-5)mol L(-1), with a detection limit of 3.5x10(-7)molL(-1). A 500-fold of sucrose and amylam, 100-fold of ascorbic acid, 120-fold of uric acid as well as gluconic acid did not interfere with 1.0x10(-5)mol L(-1) GO determination.

A new series of bone affinity compounds were synthesized by linking emodin with 5-fluorouracil derivatives. Their bone affinities were established by hydroxyapative (HA) affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.

To explore the clinical application and significance of the technique of orthotopic liver resection.From January 2004 to December 2011, five patients with huge hepatocellular carcinoma with invasion or severe adhesion of diaphragm were undergone right semi-liver resection using the technique of orthotopic liver resection. The right hemi-liver was isolated from the first liver portal, second liver portal and third liver portal, then isolated from the normal liver, finally the tumor and the invaded diaphragm were resected or removed from the severe adhesion. The approach to hepatic resection involved routine use of Peng's multifunctional operative dissector, selective control of in and out-flow of liver, control of inferior vena cava (IVC) and liver hanging maneuver, anterior approach, etc.The operations were successfully performed in 5 patients. Operative time was 120, 180, 150, 150 and 160 min, respectively. The amount of blood loss were 350, 350, 400, 450, 600 ml, respectively. Postoperative complications were pleural effusion in 3 cases, and other 2 cases recovered without complications.Although the technique of orthotopic liver resection has a high technical requirement for surgeons, it provides a surgical method and operative opportunity for the patients whose tumor has invaded diaphragm or has been severe adhesion with diaphragm and conventional liver resection cannot be performed.

The voltammetric behaviors of inosine at La(OH)3 nanowires (LNW) modified carbon paste electrode (LNW/CPE) in the presence of Cu(II) ion and K2S2O8 were investigated. The oxidation peak at 0.20 V was attributed to inosine oxidation in the formed inosine–Cu(II) complex, while the reduction peak at −0.20 V was attributed to Cu(II) ion reduction in the complex. The electrochemical oxidation potential of inosine was reduced, and the analytical sensitivity and selectivity was improved. A novel sensing system for monitoring inosine was proposed. The oxidation peak current at 0.20 V was rectilinear with inosine concentration in the range of 4.0 × 10−9–2.0 × 10−8 mol L−1, with a detection limit of 8.3 × 10−10 mol L−1. The proposed system was applied to inosine determination in both pharmaceutical preparations and human serum. Keywords: Inosine, Lanthanum hydroxide nanowire, Inosine–Cu(II) complex

Objective: This study was performed to investigate bone deteriorations of diabetic mice in response to the treatment of ursolic acid derivative (UAD). Methods: The biomarkers in serum and urine were measured, tibias were taken for the measurement on gene and protein expression and histomorphology analysis, and femurs were taken for the measurement on bone Ca and three-dimensional architecture of trabecular bone. Results: UAD showed a greater increase in bone Ca, BMD and significantly increased FGF-23 and OCN, reduced PTH and CTX in diabetic mice. UAD reversed STZ-induced trabecular deleterious effects and stimulated bone remodeling. The treatment of STZ group with UAD significantly elevated the ratio of OPG/RANKL. Moreover, insulin and IGF-1 showed a negative correlation with both FBG and Hb1Ac in STZ group. We attributed down-regulating the level of Hb1Ac in diabetic mice to that ursolic acid derivative could primely control blood sugar levels. After analyzing of two adipocyte markers, PPARγ and aP2, increased expression in the tibias of diabetic mice, and UAD could improve STZ-induced adipocyte dysfunction. Conclusions: These results demonstrated that UAD could ameliorate STZ-induced bone deterioration through improving adipocyte dysfunction and enhancing new bone formation and inhibiting absorptive function of osteoclast in the bone of diabetic mice.

There is lack of data about patient characteristics, practice patterns, and long-term adverse outcomes in patients with atrial fibrillation (AF) attending emergency departments (EDs) in China. A total of 2016 patients from 20 representative EDs were included. During 1 year, all-cause mortality was 291 (14.6%) cases, stroke/noncentral nervous system systemic embolism rate was 159 (8.0%) cases, and major bleeding was 26 (1.3%) cases. Heart failure, the major cause of mortality, accounted for 43.0% of deaths. Of 375 (18.6%) patients who used warfarin at baseline, only 217 (57.9%) patients were still on anticoagulation therapy during 1-year follow-up. Compared with the patients who continued on warfarin, the mortality rate was higher in those who did not continue (15.9% vs 5.5%, P < .001). Patients seen in ED with AF appear to have a high incidence rate of long-term all-cause mortality and inadequate anticoagulation rate.

In order to reveal the community structure characteristics of phytoplankton and the relationships with environmental factors in Hengshan Reservoir, the phytoplankton species composition, abundance, biomass and 12 environmental factors at 4 sampling sites were analyzed from March 2011 to February 2012. A total of 246 phytoplankton species were identified, which belong to 78 genera and 7 phyla. The dominant species were Melosira varians, M. granulate, Cyclotella meneghiniana, Asterianella formosa, Synedra acus, Achnanthes exigua, Ankistrodesmus falcatus, Oscillatoria lacustris, Cryptomonas erosa, Chroomonas acuta, Phormidium tenue and Microcystis aeruginosa, etc. Seasonal variations of species were obvious. The annual abundance and biomass of the phytoplankton were 0.51 x 10(5)-14.22 x 10(5) ind x L(-1) and 0.07-1.27 mg x L(-1), respectively. The values of the Margelef index, Pielou index and Shannon index of the phytoplankton community were 1.10-3.33, 0.26-0.81 and 0.51-2.38, respectively. The phytoplankton community structure was of Bacillariophyta-Cryptophyta type in spring and winter, of Chlorophyta-Cyanophyta type in summer, and of Bacillariophyta type in autumn. Canonical correlation analysis (CCA) showed that temperature, transparency, chemical oxygen demand and pH had the closest relationships with the phytoplankton community structure in the reservoir. Water quality evaluation showed that Hengshan Reservoir was in a secondary pollution with a meso-trophic level.

The authors set up a prospective study of the effect of conservative treatment on a ruptured lumbar disc herniation in 89 patients, between June 2008 and June 2010. Seventy-two patients (81%) improved, while the other 17 (19%) needed surgery. The JOA score (best possible result: 29) was found to be significantly improved in the 72 patients of the conservative group, at 1 month, 3 months, 6 months, 1 year and 2 years (t-test: p0.001). At final follow-up, after 2 years, 84.7% of the patients in the conservative group had a good or excellent result. However, if the 17 surgical cases were included, this proportion dropped to 68.5%. The volume of the protrusion decreased significantly in the 72 patients of the conservative group: from 1422.52 +/- 539.10 mm3 to 102735 +/- 585.51 mm3 (paired t-test: p0.001). There was a definite correlation, in the conservative group, between the final resorption rate on the one hand and the percentage of combined excellent and good results on the other hand (72 cases; Spearman rank correlation coefficient: r 0.01 = 0.470, p0.001).

Contemporary clinical risk stratification schemata for predicting stroke and thromboembolism in patients with atrial fibrillation (AF) are largely derived from western cohorts. The purpose of the present study is to assess the potential risk factors for stroke and major adverse cardiac events (MACE) in a large population of Chinese AF patients presenting to emergency department.The Chinese AF registry is a multicenter, prospective, observational study with 1 year follow up. Patients who presented to an emergency department with atrial fibrillation or atrial flutter were recruited from November 2008 to October 2011. The MACE included all cause mortality, stroke, non-central nervous system systemic embolism and major bleed.A total of 2016 AF patients (1104 women) were included in the final analysis. Multivariate Cox regression analysis showed that the risk factors for stroke were female gender (1.419 (1.003-2.008), p=0.048), age ≥ 75 (2.576 (1.111-4.268), p0.001), previous stroke/TIA (2.039 (1.415-2.939), p0.001), LVSD (1.700 (1.015-2.848), p=0.044) and previous major bleeding (2.481 (1.141-5.397), p=0.022). For MACE, age ≥ 75 (3.042 (2.274-4.071), p0.001), heart failure (1.371 (1.088-1.728), p=0.008), previous stroke/TIA (1.560 (1.244-1.957), p0.001), LVSD (1.424 (1.089-1.862), p=0.010) and COPD (1.393 (1.080-1.798), p=0.011) were independent risk factors. History of hypertension and diabetes was not associated with the events, neither stroke nor MACE. For non-anticoagulation patients, the c-statistic for predicting stroke was 0.685 (0.637-0.732) and for MACE was 0.717 (0.687-0.746), respectively.We demonstrated that, except for the traditional risk factors, clinicians should pay more attention to patients with prior major bleeding or COPD in Chinese AF patients presenting to emergency department.

Background We summarize our experience of the diagnosis, surgical treatment, and prognosis of solid pseudopapillary tumors (SPTs). Methods We carried out a retrospective study of clinical data from a series of 17 patients with SPT managed in two hospitals between October 2001 and November 2011. Results All of the 17 patients were female and the average age at diagnosis was 26.6 years (range 11 years to 55 years). The tumor was located in the body or tail in ten patients, the head in five patients, and the neck in two patients. The median tumor size was 5.5 cm (range 2 cm to 10 cm). All 17 patients had curative resections, including seven distal pancreatectomies, five local resections, four pancreaticoduodenectomies, and one central pancreatectomy. Two patients required concomitant splenic vein resection due to local tumor invasion. All patients were alive and disease-free at a median follow-up of 48.2 months (range 2 to 90 months). There were no significant associations between clinicopathologic factors and malignant potential of SPT. Ki-67 was detected in three patients with pancreatic parenchyma invasion. Conclusions The SPT is an infrequent tumor, typically affecting young women without notable symptoms. Surgical resection is justified even in the presence of local invasion or metastases, as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential of SPTs.

We study the possible heavy molecular states composed of a pair of charm mesons in the H and S doublets. Since the P-wave charm-strange mesons $D_{s0}(2317)$ and $D_{s1}(2460)$ are extremely narrow, the future experimental observation of the possible heavy molecular states composed of $D_s/D_s^\ast$ and $D_{s0}(2317)/D_{s1}(2460)$ may be feasible if they really exist. Especially the possible $J^{PC}=1^{--}$ states may be searched for via the initial state radiation technique., 42 pages, 4 tables, 31 figures. Improved numerical results and Corrected typos.

To investigate the expression of multidrug resistance (MDR) gene-associated proteins (MRP) in gastric carcinoma, and their effects on the postoperative adjuvant chemotherapy and the prognosis of patients.The expressions of ToPo II, MRP, GST-pi in 99 patients with gastric carcinoma were detected by immunohistochemistry. The expression and its relationship to the pathological data were analyzed. The positive expression of MRP and GST-pi, and the negative expression of ToPo II were considered as risk factors. Patients were divided into two groups: a high risk drug-resistant group (2-3 risk factors) and the low risk drug-resistant group (0-1 risk factors). Postoperative recurrence, survival rate, and efficacy of adjuvant chemotherapy were compared between two groups.The positive rate of ToPo II was 74.7%, and the expression was associated with types and differentiation of the tumor. The positive rate of GST-pi was 49.5%, and the expression was related to the gender and the differentiation. The positive rate of MRP was 40.4%, and there was no relationship between the MRP expression and the pathological finding. There were no significant differences in the recurrence, time to recurrence, and the 5-year survival rate between the positive and negative group of the three proteins (P0.05). Recurrence was found in 25 cases(55.6%) in the high risk drug-resistant group and the mean time to recurrence was (15.2+/-8.1) months. The time to recurrence was shorter in the low risk drug-resistant group [(21.3+/-11.1) months, P0.05] , but there was no significant difference in the recurrence rate between two groups (P0.05). The 5-year survival rate of the high risk drug-resistant group and the low risk drug-resistant group was 44.4% and 55.6% (P0.05). The 5-year survival rates of patients with or without chemotherapy in the high risk drug-resistant group were 45.8% and 42.9% (P0.05). The 5-year survival rates of patients with or without chemotherapy in the low risk drug-resistant group were 70.4% and 40.7%. The survival rate of patients with chemotherapy was higher than that of the patients without chemotherapy (P0.05).The expression of ToPo II, MRP and GST-pi is associated with the efficacy of postoperative adjuvant chemotherapy. Chemotherapy appears to be more beneficial to patients with low risk drug-resistance.

The P-wave charm-strange mesons $D_{s0}(2317)$ and $D_{s1}(2460)$ lie below the $DK$ and $D^\ast K$ threshold respectively. They are extremely narrow because their strong decays violate the isospin symmetry. We study the possible heavy molecular states composed of a pair of excited charm strange mesons. As a byproduct, we also present the numerical results for the bottonium-like analogue., Comment: 15 pages, 12 tables. More dicussions added and typos corrected. Accepted for publication in Chinese Physics C

In this paper, a novel palmprint recognition approach is presented. A modified discrete cosine transform based feature extraction method is used to obtain palmprint features. Furthermore, a radial basis function neural network is employed for palmprint classification. In order to facilitate the training of radial basis function neural network, principal components analysis is applied to reduce these features to a reasonable dimension. The experiment results show that the method is effective.

Abdominal cocoon syndrome (ACS) is a rare cause of intestinal obstruction due to total or partial encapsulation of the small intestine by a fibrocollagenous membrane. Idiopathic ACS with abdominal cryptorchidism and greater omentum hypoplasia is even rarer clinically. We successfully treated a 26-year-old male case of small bowel obstruction with acute peritonitis. He was finally diagnosed with idiopathic ACS with unilateral abdominal cryptorchidism and greater omentum hypoplasia during exploratory laparotomy. He then underwent enterolysis, cryptorchidectomy, and appendectomy. He recovered gradually from the operations and early postoperative inflammatory ileus. There has been no recurrence of intestinal obstruction since the operation, and he is still in follow-up. We analyzed his clinical data and retrospectively reviewed the literature, and our findings may be helpful for the clinical diagnosis and treatment on ACS.