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384 results on '"Paczek, Leszek"'

53. Successful transplantation of kidneys from deceased donors with terminal acute kidney injury

Author

Domagala, Piotr, primary, Gorski, Lukasz, additional, Wszola, Michal, additional, Kieszek, Rafal, additional, Diuwe, Piotr, additional, Goralski, Piotr, additional, Drozdowski, Jakub, additional, Ostaszewska, Agata, additional, Gozdowska, Jolanta, additional, Ciszek, Michal, additional, Trzebicki, Janusz, additional, Durlik, Magdalena, additional, Paczek, Leszek, additional, Chmura, Andrzej, additional, and Kwiatkowski, Artur, additional

Published
2019
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56. Additional file 1: of Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties

Author

Zarychta-WiśNiewska, Weronika, Burdzinska, Anna, Kulesza, Agnieszka, Gala, Kamila, Kaleta, Beata, Zielniok, Katarzyna, Siennicka, Katarzyna, Sabat, Marek, and Paczek, Leszek

Abstract

Study design scheme. Diagram shows the steps in the course of the study. After 7Â days of culture with or without BMP-12 supernatants were collected and cells harvested. Depending on the requirements of each experiment cells were plated in 96- or 24-well plate. For analysis of gene expression RNA was isolated immediately after the end of treatment. (PDF 686Â kb)

Published
2017
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58. Low Transfer of Tacrolimus and Its Metabolites into Colostrum of Graft Recipient Mothers

Author

Kociszewska-Najman, Bozena, primary, Mazanowska, Natalia, additional, Pietrzak, Bronislawa, additional, Paczek, Leszek, additional, Szpotanska-Sikorska, Monika, additional, Schreiber-Zamora, Joanna, additional, Hryniewiecka, Ewa, additional, Zochowska, Dorota, additional, Samborowska, Emilia, additional, Dadlez, Michal, additional, and Wielgos, Miroslaw, additional

Published
2018
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64. Additional file 1: Table S1. of Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

Author

Perkowska-Ptasinska, Agnieszka, Deborska-Materkowska, Dominika, Bartczak, Artur, Stompor, Tomasz, Liberek, Tomasz, Bullo-Piontecka, Barbara, Wasinska, Anna, Serwacka, Agnieszka, Klinger, Marian, Chyl, Jolanta, Kuriga, Michal, Malecki, Robert, Marczewski, Krzysztof, Hryniewicz, Bogdan, Gregorczyk, Tadeusz, Wieliczko, Monika, Niemczyk, Stanislaw, Rostkowska, Olga, Paczek, Leszek, and Durlik, Magdalena

Abstract

The list of kidney biopsy diagnoses. Contains morphological diagnoses which occurred at least once in the study group. (DOC 33 kb)

Published
2016
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65. Additional file 2: Table S2. of Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

Author

Perkowska-Ptasinska, Agnieszka, Deborska-Materkowska, Dominika, Bartczak, Artur, Stompor, Tomasz, Liberek, Tomasz, Bullo-Piontecka, Barbara, Wasinska, Anna, Serwacka, Agnieszka, Klinger, Marian, Chyl, Jolanta, Kuriga, Michal, Malecki, Robert, Marczewski, Krzysztof, Hryniewicz, Bogdan, Gregorczyk, Tadeusz, Wieliczko, Monika, Niemczyk, Stanislaw, Rostkowska, Olga, Paczek, Leszek, and Durlik, Magdalena

Subjects
health care facilities, manpower, and services, social sciences, humanities
Abstract

Pre-biopsy follow-up in selected nephropathies in elderly and younger patients. (DOCX 12 kb)

Published
2016
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72. Antibiotic resistance profiles of strictly anaerobic Gram-negative Bacteroides spp. and Parabacteroides spp. bacilli isolated from infected inpatients on surgical wards

Author

Kierzkowska, Marta, primary, Majewska, Anna, additional, Sawicka-Grzelak, Anna, additional, Mlynarczyk, Andrzej, additional, Chmura, Andrzej, additional, Kwiatkowski, Artur, additional, Durlik, Madgalena, additional, Paczek, Leszek, additional, and Mlynarczyk, Grazyna, additional

Published
2016
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74. Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

Author

Perkowska-Ptasinska, Agnieszka, primary, Deborska-Materkowska, Dominika, additional, Bartczak, Artur, additional, Stompor, Tomasz, additional, Liberek, Tomasz, additional, Bullo-Piontecka, Barbara, additional, Wasinska, Anna, additional, Serwacka, Agnieszka, additional, Klinger, Marian, additional, Chyl, Jolanta, additional, Kuriga, Michal, additional, Malecki, Robert, additional, Marczewski, Krzysztof, additional, Hryniewicz, Bogdan, additional, Gregorczyk, Tadeusz, additional, Wieliczko, Monika, additional, Niemczyk, Stanislaw, additional, Rostkowska, Olga, additional, Paczek, Leszek, additional, and Durlik, Magdalena, additional

Published
2016
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80. The paradox of the 21st century – is there really an epidemic of most common killers?

Author

Nowak, Marcin and Paczek,Leszek

Subjects
International Journal of General Medicine
Abstract

Leszek Paczek, Marcin NowakTransplantation Institute, Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, PolandAbstract: Over the last 110 years, average global life expectancy has more than doubled from 31 years of age to 65 years of age. This trend is expected to continue, and many of the children born after the year 2000 can expect to live to celebrate their hundredth birthday. In the last 20 years alone, average life expectancy has increased globally by 6 years. During the same period, doctors have announced a global epidemic of the most common killers: cardiovascular disease, diabetes, chronic kidney, and chronic obstructive pulmonary disease. One of the most important reasons for the more frequent recognition of these diseases is the fact that their diagnostic criteria have changed and become much more acute during the past few years.These changes in diagnostic criteria have made it difficult, or even impossible, to compare the present statistical data regarding these diseases to historical data for the same illnesses. Due to this difficulty, there is no evidence-based comparison of the prevalence of any disease at present and in the past. Before announcing a global epidemic, a fair epidemiological comparison should be made, based upon the same definitions and using identical diagnostic tools. Keywords: global life expectancy, epidemic of CVD, DM, CKD, COPD

Published
2011

83. SP368RENAL DISEASE IN ELDERLY: DATA FROM 14 LARGE NEPHROLOGICAL CENTERS IN POLAND

Author

Perkowska-Ptasinska, Agnieszka, primary, Bartczak, Artur, additional, Liberek, Tomasz, additional, Wasinska, Anna, additional, Serwacka, Agnieszka, additional, Chyl, Jolanta, additional, Kuriga, Michal, additional, Malecki, Robert, additional, Marczewski, Krzysztof, additional, Stompor, Tomasz, additional, Hryniewicz, Bogdan, additional, Gregorczyk, Tadeusz, additional, Niemczyk, Stanislaw, additional, Wieliczko, Monika, additional, Rostkowska, Olga, additional, Klinger, Marian, additional, Paczek, Leszek, additional, and Durlik, Magdalena, additional

Published
2015
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86. Arteriovenous oscillations of the redox potential: Is the redox state influencing blood flow?

Author

Poznanski, Jaroslaw, Szczesny, Pawel, Pawlinski, Bartosz, Mazurek, Tomasz, Zielenkiewicz, Piotr, Gajewski, Zdzislaw, and Paczek, Leszek

Subjects
VASCULAR endothelium, OXIDATION-reduction potential, LASER Doppler blood flowmetry, HEART beat, LABORATORY swine, PHYSIOLOGY
Abstract

Objective:Studies on the regulation of human blood flow revealed several modes of oscillations with frequencies ranging from 0.005 to 1 Hz. Several mechanisms were proposed that might influence these oscillations, such as the activity of vascular endothelium, the neurogenic activity of vessel wall, the intrinsic activity of vascular smooth muscle, respiration, and heartbeat. These studies relied typically on non-invasive techniques, for example, laser Doppler flowmetry. Oscillations of biochemical markers were rarely coupled to blood flow. Methods:The redox potential difference between the artery and the vein was measured by platinum electrodes placed in the parallel homonymous femoral artery and the femoral vein of ventilated anesthetized pigs. Results:Continuous measurement at 5 Hz sampling rate using a digital nanovoltmeter revealed fluctuating signals with three basic modes of oscillations: ∼ 1, ∼ 0.1 and ∼ 0.01 Hz. These signals clearly overlap with reported modes of oscillations in blood flow, suggesting coupling of the redox potential and blood flow. Discussion:The amplitude of the oscillations associated with heart action was significantly smaller than for the other two modes, despite the fact that heart action has the greatest influence on blood flow. This finding suggests that redox potential in blood might be not a derivative but either a mediator or an effector of the blood flow control system. [ABSTRACT FROM PUBLISHER]

Published
2017
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87. [Current status of liver transplantation]

Author

Malkowski, Piotr, Czerwinski, Jaroslaw, Pacholczyk, Marek, Chmura, Andrzej, Lagiewska, Beata, Paczek, Leszek, Adadynski, Leszek, Wasiak, Darek, Kosieradzki, Maciej, Kwiatkowski, Artur, Rowinski, Wojciech, Janusz Trzebicki, Kalicinski, Piotr, Kaminski, Andrzej, Pawlowska, Joanna, Patrzalek, Dariusz, Polak, Wojciech, Wojcicki, Maciej, Lubikowski, Jerzy, Zeair, Samir, and Czuprynska, Malgorzata

Subjects
Adult, Treatment Outcome, Biliary Atresia, Liver Diseases, Cadaver, Living Donors, Humans, Poland, Tissue Preservation, Child, Fibrosis, Tissue Donors, Liver Transplantation
Abstract

The authors present current status of liver transplantation (LTx) in Poland. Till 2004, 845 LTx were performed: 604 in adults and 241 in children; 71 of them were the living donor LTx. Post-inflammatory cirrhosis in adults and biliary atresia in children were the most common indications for LTx. The results of LTx in Poland are good and comparable with the results published by other centers. The number of available cadaveric grafts is growing and in 2004 achieved an index of harvesting as high as 14,7 per million people.

Published
2005

88. Age-dependent increase in serum levels of indoxyl sulphate and p-cresol sulphate is not related to their precursors: Tryptophan and tyrosine.

Author

Wyczalkowska‐Tomasik, Aleksandra, Czarkowska‐Paczek, Bozena, Giebultowicz, Joanna, Wroczynski, Piotr, and Paczek, Leszek

Subjects
AGE distribution, HIGH performance liquid chromatography, MASS spectrometry, PHENOLS, RESEARCH funding, TRYPTOPHAN, TYROSINE, DATA analysis software, DESCRIPTIVE statistics
Abstract

Aim Retention of indoxyl sulphate and p-cresol sulphate is associated with many diseases. The aim of the present study was to examine serum levels of indoxyl sulphate and p-cresol sulphate, the dynamics of their changes according to age, and their precursors. Methods The study included 180 healthy individuals aged 20-90 years ( n = 180), divided into subgroups by decade ( n = 30 in each subgroup) and into subgroups of ≥65 years ( n = 42) or <65 years ( n = 138). Serum indoxyl sulphate and p-cresol sulphate, tryptophan, and tyrosine were measured using high-performance liquid chromatography-mass spectrometry. Results The 70-90 years age group had higher indoxyl sulphate than the 50-59 years age group ( P = 0.033). The 70-90 years age group had higher p-cresol sulphate than the 20-29 years ( P < 0.001), 30-39 years ( P < 0.001), 40-49 years ( P = 0.007) and 50-59 years ( P = 0.001) age groups; the 60-69 years age group had higher p-cresol sulphate than the 20-29 years ( P = 0.043) and 30-39 years ( P = 0.011) age groups. Indoxyl sulphate and p-cresol sulphate serum levels were higher in those aged ≥65 years. Indoxyl sulphate and p-cresol sulphate serum levels correlated positively with age, but not with tryptophan and tyrosine, respectively. Conclusions Healthy aging is associated with indoxyl sulphate and p-cresol sulphate serum level increases, which are not linked to tryptophan and tyrosine serum levels. Geriatr Gerontol Int 2017; 17: 1022-1026. [ABSTRACT FROM AUTHOR]

Published
2017
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89. Mesenchymal Stem Cells from Human Amniotic Membrane and Umbilical Cord Can Diminish Immunological Response in an in vitro Allograft Model.

Author

Dabrowski, Filip a., Burdzinska, anna, Kulesza, agnieszka, Chlebus, Marcin, Kaleta, Beata, Borysowski, Jan, Zolocinska, aleksandra, Paczek, Leszek, and Wielgos, Miroslaw

Subjects
AMNION, PROGENITOR cells, STEM cell culture, EMBRYOLOGY, UMBILICAL cord, IMMUNE system physiology, ADIPOSE tissues, CELL culture, CELL physiology, CONNECTIVE tissue cells, HOMOGRAFTS, IMMUNOLOGY technique, LYMPHOCYTES
Abstract

Background/aim: Mesenchymal stem cells (MSCs) are gaining rising interest in gynecology and obstetrics. MSCs immunomodulatory properties are suitable enough to reduce perinatal morbidity caused by inflammation in premature neonates. The aim of this study was to evaluate and compare the ability to inhibit allo-activated lymphocytes proliferation by MSCs derived from different sources: amniotic membrane (AM), umbilical cord (UC) and adipose tissue (AT).Methods: MSCs were isolated from AM (n = 7) and UC (n = 6) and AT (n = 6) of healthy women. Cells were characterized by flow cytometry and differentiation assay. To evaluate the potential of fetal and adult MSCs to diminish immunological response, mixed lymphocytes reaction (MLR) was performed.Results: Amnion and UC-derived cells displayed typical MSCs characteristics. Addition of MSCs to MLR significantly inhibited the proliferation of stimulated lymphocytes. The effect was observed regardless of the MSCs type used (p < 0.01 in all groups). Comparative analysis revealed no significant differences in this action between tested MSCs types. Additionally, no type of MSCs significantly stimulated allogeneic lymphocytes.Conclusion: The results prove the immunosuppressive capacities of fetal-derived MSCs in vitro. In the future, they may be potentially used to treat premature newborn as well as in immunomodulation in post-transplant therapy. [ABSTRACT FROM AUTHOR]

Published
2017
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93. The paradox of the 21st century – is there really an epidemic of most common killers?

Author

Paczek,Leszek, Nowak,Marcin, Paczek,Leszek, and Nowak,Marcin

Abstract

Leszek Paczek, Marcin NowakTransplantation Institute, Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, PolandAbstract: Over the last 110 years, average global life expectancy has more than doubled from 31 years of age to 65 years of age. This trend is expected to continue, and many of the children born after the year 2000 can expect to live to celebrate their hundredth birthday. In the last 20 years alone, average life expectancy has increased globally by 6 years. During the same period, doctors have announced a global epidemic of the most common killers: cardiovascular disease, diabetes, chronic kidney, and chronic obstructive pulmonary disease. One of the most important reasons for the more frequent recognition of these diseases is the fact that their diagnostic criteria have changed and become much more acute during the past few years.These changes in diagnostic criteria have made it difficult, or even impossible, to compare the present statistical data regarding these diseases to historical data for the same illnesses. Due to this difficulty, there is no evidence-based comparison of the prevalence of any disease at present and in the past. Before announcing a global epidemic, a fair epidemiological comparison should be made, based upon the same definitions and using identical diagnostic tools. Keywords: global life expectancy, epidemic of CVD, DM, CKD, COPD

Published
2011

98. Inflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges.

Author

Wyczalkowska-Tomasik, Aleksandra, Czarkowska-Paczek, Bozena, Zielenkiewicz, Magdalena, and Paczek, Leszek

Abstract

We examined the serum levels of IL-6, IL-8, TNF, IL-6R, TNF-R1, and CRP and the dynamics of changes in these levels according to age. The study included healthy individuals of 20-90 years of age. Participants were divided into subgroups based on their decade of life, and into subgroups of ≥65 or <65 years. Serum cytokine levels were assayed by ELISA, and CRP using an immunoturbidimetric method. Serum CRP levels were within the normal range for all subgroups. The 60- to 70-year age group showed higher CRP than the 20- to 30- ( p = 0.003), 30- to 40- ( p = 0.009), and 40- to 50- ( p = 0.030) year age groups. Serum cytokine levels were low. It was greater in the 60- to 70-year age group than in the 20- to 30- ( p = 0.008) and 30- to 40- ( p = 0.040) year groups, and was greater in the 70- to 90-year group than the 20- to 30-year group ( p = 0.043). Serum TNF-R1 level in the 70- to 90-year group was greater than in all other age groups ( p = 0.000 for all comparisons). Other measured parameters did not differ between groups. Serum levels of IL-6, CRP, and TNF-R1 were greater in participants ≥65 than <65 years of age. Healthy older people showed low serum levels of CRP and pro-inflammatory cytokines, but higher than in younger population. Therefore, the adjustment of normal ranges in the elderly should be considered. Serum levels of pro-inflammatory cytokines elevated beyond normal ranges indicate particular diseases. [ABSTRACT FROM AUTHOR]

Published
2016
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100. Urine proteome of autosomal dominant polycystic kidney disease patients

Author

Bakun, Magda, primary, Niemczyk, Mariusz, additional, Domanski, Dominik, additional, Jazwiec, Radek, additional, Perzanowska, Anna, additional, Niemczyk, Stanislaw, additional, Kistowski, Michal, additional, Fabijanska, Agnieszka, additional, Borowiec, Agnieszka, additional, Paczek, Leszek, additional, and Dadlez, Michal, additional

Published
2012
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