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52. Treatment of chronic venous disease with flavonoids: recommendations for treatment and further studies

Author

Rabe, E., Guex, J-J, Morrison, N., Ramelet, A-A, Schuller-Petrovic, S., Scuderi, A., Staelens, I., Pannier, F., Rabe, E., Guex, J-J, Morrison, N., Ramelet, A-A, Schuller-Petrovic, S., Scuderi, A., Staelens, I., and Pannier, F.

Abstract

Objectives: A variety of studies have suggested that flavonoids are effective for the treatment of CVD. However, many questions remain about their mechanism of action and when, how, and for what signs and symptoms they should be used. Method: A panel of experts in CVDmet in Budapest, Hungary in December 2011 to discuss the current state of knowledge of CVD and the role of flavonoids in its treatment. The discussion was based on a literature search in the current databases. The goals of this paper are recommendations for further studies on the use of flavonoids in the treatment of CVD. Results: There is good evidence to recommend the use of flavonoids in the treatment of CVD. However, because of the poor quality of some older clinical trials, inadequate reporting, and insufficient information, much work is still needed to firmly establish their clinical efficacy and to determine when and how they should be employed. In particular, long-term randomized, placebo-controlled, double-blind studies are needed to establish the efficacy and safety of flavonoids. Additional studies are also needed to establish their mechanism of action, pharmacokinetics, toxicity, and cost-effectiveness. Conclusions: Aside from good evidence for the use of flavonoids in CVD further studies are indicated to establish long term treatment in this indication.

Published
2013

53. European guidelines for sclerotherapy in chronic venous disorders

Author

Rabe, E., Breu, F., Cavezzi, A., Coleridge Smith, P., Frullini, A., Gillet, J., Guex, J., Hamel-Desnos, C., Kern, P., Partsch, B., Ramelet, Anne-Sylvie, Tessari, L., Pannier, F., Rabe, E., Breu, F., Cavezzi, A., Coleridge Smith, P., Frullini, A., Gillet, J., Guex, J., Hamel-Desnos, C., Kern, P., Partsch, B., Ramelet, Anne-Sylvie, Tessari, L., and Pannier, F.

Abstract

Aim: Sclerotherapy is the targeted chemical ablation of varicose veins by intravenous injection of a liquid or foamed sclerosing drug. The treated veins may be intradermal, subcutaneous, and/or transfascial as well as superficial and deep in venous malformations. The aim of this guideline is to give evidence-based recommendations for liquid and foam sclerotherapy. Methods: This guideline was drafted on behalf of 23 European Phlebological Societies during a Guideline Conference on 7-10 May 2012 in Mainz. The conference was organized by the German Society of Phlebology. These guidelines review the present state of knowledge as reflected in published medical literature. The regulatory situation of sclerosant drugs differs from country to country but this has not been considered in this document. The recommendations of this guideline are graded according to the American College of Chest Physicians Task Force recommendations on Grading Strength of Recommendations and Quality of Evidence in Clinical Guidelines. Results: This guideline focuses on the two sclerosing drugs which are licensed in the majority of the European countries, polidocanol and sodium tetradecyl sulphate. Other sclerosants are not discussed in detail. The guideline gives recommendations concerning indications, contraindications, side-effects, concentrations, volumes, technique and efficacy of liquid and foam sclerotherapy of varicose veins and venous malformations.

Published
2013

55. Predictive model for chronic venous insufficiency

Author

Hennig, F, Hertel, S, Hoffmann, B, Pannier, F, Ko, A, Berboth, G, Rabe, E, Jöckel, KH, Hennig, F, Hertel, S, Hoffmann, B, Pannier, F, Ko, A, Berboth, G, Rabe, E, and Jöckel, KH

Published
2011

70. Towards a new Certified Reference Material for butyltins, methylmercury and arsenobetaine in oyster tissue

Author

Morabito, R, Massanisso, P, Camara, C, Larsson, Tom, Frech, Wolfgang, Kramer, KJM, Bianchi, M, Muntau, H, Donard, OFX, Lobinski, R, McSheehy, S, Pannier, F, Potin-Gautier, M, Gawlik, BM, Bowadt, S, Quevauviller, P, Morabito, R, Massanisso, P, Camara, C, Larsson, Tom, Frech, Wolfgang, Kramer, KJM, Bianchi, M, Muntau, H, Donard, OFX, Lobinski, R, McSheehy, S, Pannier, F, Potin-Gautier, M, Gawlik, BM, Bowadt, S, and Quevauviller, P

Abstract

Increasing awareness of the determination of chemical species in the environment evolves jointly with the need to control the validity of analytical measurements in a wide variety of matrices. There are few Certified Reference Materials (CRMs) available for various chemical species, and they are certified for species of one single element (e.g., species of tin and mercury). Three years of collaboration within the framework of European Commission research programmes involving more than 20 laboratories have made it possible to produce an oyster reference material for species of tin, mercury and arsenic (BCR-710) and to perform the necessary experimental work for its certification. This article summarises the feasibility study and describes the various steps in the preparation, production and characterisation of this material for its content of arsenobetaine, methylmercury, tributyltin and dibutyltin. These steps included stability and homogeneity testing as well as value assignment based on a collaborative approach involving a group of European laboratories. Further work is going on to certify total contents for a range of trace metals.

Published
2004
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75. Leitlinie zur Diagnostik und Therapie der Krampfadererkrankung

Author

Kluess, H.G., primary, Noppeney, T., primary, Breu, F.X., primary, Ehresmann, U., primary, Gerlach, H.E., primary, Hermanns, H.-J., primary, Nüllen, H., primary, Pannier, F., primary, Salzmann, G., primary, Schimmelpfennig, L., primary, Schmedt, C.-G., primary, Steckmeier, B., primary, and Stenger, D., primary

Published
2010
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100. Europske smjernice za skleroterapiju kod kroničnih venskih poremećaja.

Author

Rabe, E., Breu, F. X., Cavezzi, A., Coleridge Smith, P., Frullini, A., Gillet, J. L., Guex, J. J., Hamel-Desnos, C., Kern, P., Partsch, B., Ramelet, A. A., Tessari, L., and Pannier, F.

Subjects
SCLEROTHERAPY, DRUG therapy, VARICOSE veins, VEIN diseases, PHARMACODYNAMICS, THERAPEUTICS
Abstract

Copyright of Acta Medica Croatica is the property of Croatian Academy of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

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