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55. 'Frozen-Ground Cartoons' : Permafrost comics as an innovative tool for polar outreach, education, and engagement

Author

Bouchard, Frederic, Sansoulet, Julie, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Rudy, Ashley C. A., Siewert, Matthias B., Sjöberg, Ylva, Tanski, George, Habeck, J. Otto, Harbor, Jon, Bouchard, Frederic, Sansoulet, Julie, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Rudy, Ashley C. A., Siewert, Matthias B., Sjöberg, Ylva, Tanski, George, Habeck, J. Otto, and Harbor, Jon

Abstract

Permafrost occupies 20 million square kilometres of Earth's high-latitude and high-altitude landscapes. These regions are sensitive to climate change and human activities; hence, permafrost research is of considerable scientific and societal importance. However, the results of this research are generally not known by the general public. Communicating scientific concepts is an increasingly important task in the research world. Different ways to engage learners and incorporate narratives in teaching materials exist, yet they are generally underused. Here we report on an international scientific outreach project called "Frozen-Ground Cartoons", which aims at making permafrost science accessible and fun for students, teachers, and parents through the creation of comic strips. We present the context in which the project was initiated, as well as recent education and outreach activities. The future phases of the project primarily involve a series of augmented reality materials, such as maps, photos, videos, and 3D drawings. With this project we aim to foster understanding of permafrost research among broader audiences, inspire future permafrost researchers, and raise public and science community awareness of polar science, education, outreach, and engagement.

Published
2018
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56. Es taut! Frozen-Ground Cartoons: Eine internationale Kooperation zwischen Künstlern und Permafrost-Wissenschaftlern

Author

Nääs, Heta, Ross, N., Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Siewert, Matthias Benjamin, Sjöberg, Ylva, Veillete, Audrey, Weege, Stefanie, Harbor, John, Habeck, J. Otto, Nääs, Heta, Ross, N., Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Siewert, Matthias Benjamin, Sjöberg, Ylva, Veillete, Audrey, Weege, Stefanie, Harbor, John, and Habeck, J. Otto

Abstract

Dieses Projekt startete im Oktober 2015 mit einer verrückten Idee: Schreiben und Einreichen eines Antrags auf Förderung einer internationalen, multidisziplinären und nicht-traditionell wissenschaftlichen Projektinitiative… innerhalb von 48 Stunden. Und es hat geklappt ! Eine Gruppe hoch motivierter, junger Forscher aus Kanada und Europa hat sich gebildet, um Kunst und Wissenschaft zu kombinieren und eine Reihe von Comics über Permafrost (gefrorene Böden) zu produzieren. Unser Ziel ist es, zu zeigen, wie wissenschaftliches Arbeiten im hohen Norden funktioniert, mit dem Schwerpunkt auf Geländearbeit und den schnellen Umweltveränderungen in der Arktis. Die Zielgruppe sind Kinder, Jugendliche, Eltern und Lehrer, mit dem allgemeinen Ziel, Permafrost zugänglicher und mit Spaß zu vermitteln. Denn ratet mal: Permafrost ist ein Gebiet von mehr als 20 Millionen km2 auf der Nordhalbkugel – ein riesiges Gebiet. Durch die Klimaerwärmung taut der Permafrost und wird zu instabil, um Häuser, Straßen und Flughäfen zu tragen. Durch das Auftauen von gefrorenem Boden werden außerdem Pflanzen- und Tierhabitate zerstört, die Wasserqualität und Ökologie von Seen beeinflusst und auf Grund der Freisetzung von Kohlenstoff als Treibhausgas in die Atmosphäre wird der Klimawandel sogar verstärkt. Daher betrifft Permafrost und seine Reaktion auf den Klimawandel uns alle. Die Internationale Permafrost Gemeinschaft (IPA) hat das Projekt als „Action Group“ von Beginn an unterstützt und seitdem sind noch viele weitere Sponsoren dazugekommen. Und hier sind wir nun: Zwei Jahre nach der ersten Idee. Ihr seid kurz davor das zu lesen, was das Ergebnis eines ständigen Austauschs zwischen Künstlern und Wissenschaftlern ist. Zunächst hatten wir eine Ausschreibungsrunde und erhielten 49 Bewerbungen von Künstlern aus 16 Ländern. Durch ein Bewertungsverfahren wählten wir zwei Künstlerinnen aus, um an diesem Projekt zu arbeiten: Noémie Ross aus Kanada und Heta Nääs aus Finnland. Mit den Beiträgen von Wissenscha

Published
2018

57. Extreme warming and regime shift toward amplified variability in a far northern lake.

Author

Bégin, Paschale N., Tanabe, Yukiko, Kumagai, Michio, Culley, Alexander I., Paquette, Michel, Sarrazin, Denis, Uchida, Masaki, and Vincent, Warwick F.

Subjects
ICE on rivers, lakes, etc., ANOXIC waters, ATMOSPHERIC boundary layer, LAKES, ATMOSPHERIC temperature
Abstract

Mean annual air temperatures in the High Arctic are rising rapidly, with extreme warming events becoming increasingly common. Little is known, however, about the consequences of such events on the ice‐capped lakes that occur abundantly across this region. Here, we compared 2 years of high‐frequency monitoring data in Ward Hunt Lake in the Canadian High Arctic. One of the years included a period of anomalously warm conditions that allowed us to address the question of how loss of multi‐year ice cover affects the limnological properties of polar lakes. A mooring installed at the deepest point of the lake (9.7 m) recorded temperature, oxygen, chlorophyll a (Chl a) fluorescence, and underwater irradiance from July 2016 to July 2018, and an automated camera documented changes in ice cover. The complete loss of ice cover in summer 2016 resulted in full wind exposure and complete mixing of the water column. This mixing caused ventilation of lake water heat to the atmosphere and 4°C lower water temperatures than under ice‐covered conditions. There were also high values of Chl a fluorescence, elevated turbidity levels and large oxygen fluctuations throughout fall and winter. During the subsequent summer, the lake retained its ice cover and the water column remained stratified, with lower Chl a fluorescence and anoxic bottom waters. Extreme warming events are likely to shift polar lakes that were formerly capped by continuous thick ice to a regime of irregular ice loss and unstable limnological conditions that vary greatly from year to year. [ABSTRACT FROM AUTHOR]

Published
2021
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58. Cross-Species Physiological Assessment of Brain Estrogen Receptor Expression Using 18F-FES and 18F-4FMFES PET Imaging.

Author

Paquette, Michel, Phoenix, Serge, Lavallée, Éric, Rousseau, Jacques A., Guérin, Brigitte, Turcotte, Éric E., and Lecomte, Roger

Subjects
*PREOPTIC area, *ESTROGEN receptors, *SKULL base, *BRAIN, *IMAGE fusion, *BRAIN imaging
Abstract

Purpose: A retrospective analysis was performed of preclinical and clinical data acquired during the evaluation of the estrogen receptor (ER) PET tracer 4-fluoro-11β-methoxy-16α-[18F]-fluoroestradiol (4FMFES) and its comparison with 16α-[18F]-fluoroestradiol (FES) in mice, rats, and humans with a focus on the brain uptake. Procedures: Breast cancer tumor-bearing female BALB/c mice from a previous study and female Sprague-Dawley rats (control and ovariectomized) were imaged by 4FMFES or FES-PET imaging. Immediately after, low-dose CT was performed in the same bed position. Semi-quantitative analysis was conducted to extract %ID/g data. Small cohorts of mice and rats were imaged with 4FMFES in an ultra-high-resolution small animal PET scanner prototype (LabPET II). Rat brains were dissected and imaged separately with both PET and autoradiography. In parallel, 31 breast cancer patients were enrolled in a clinical phase II study to compare 4FMFES with FES for oncological assessment. Since the head was included in the field of view, brain uptake of discernable foci was measured and reported as SUVMax. Results: Regardless of the species studied, 4FMFES and FES uptake were relatively uniform in most regions of the brain, except for bilateral foci at the base of the skull, at the midsection of the brain. Anatomical localization of the PET signal using CT image fusion indicates that the signal origins from the pituitary in all studied species. 4FMFES yielded lower pituitary uptake than FES in patients, but an inverse trend was observed in rodents. 4FMFES pituitary contrast was higher than FES in all assessed groups. High-resolution small animal imaging of the brain of rats and mice revealed a supplemental signal anterior to the pituitary, which is likely to be the medial preoptic area. Dissection data further confirmed those findings and revealed additional signals corresponding to the arcuate and ventromedial nuclei, along with the medial and cortical amygdala. Conclusion: 4FMFES allowed visualization of ER expression in the pituitary in humans and two different rodent species with better contrast than FES. Improvement in clinical spatial resolution might allow visualization and analysis of other ER-rich brain areas in humans. Further work is now possible to link 4FMFES pituitary uptake to cognitive functions. [ABSTRACT FROM AUTHOR]

Published
2020
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60. “Frozen-Ground Cartoons”: Permafrost comics as an innovative tool for polar outreach, education, and engagement

Author

Bouchard, Frédéric, primary, Sansoulet, Julie, additional, Fritz, Michael, additional, Malenfant-Lepage, Julie, additional, Nieuwendam, Alexandre, additional, Paquette, Michel, additional, Rudy, Ashley C. A., additional, Siewert, Matthias B., additional, Sjöberg, Ylva, additional, Tanski, George, additional, Habeck, J. Otto, additional, and Harbor, Jon, additional

Published
2018
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63. NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and In Vivo Tumor-Targeting Properties in a Bladder Cancer Model

Author

Paquette, Michel, primary, Beaudoin, Simon, additional, Tremblay, Mylene-Annie, additional, Jean, Steve, additional, Lopez, Angel F., additional, Lecomte, Roger, additional, Guérin, Brigitte, additional, Bentourkia, M’hamed, additional, Sabbagh, Robert, additional, and Leyton, Jeffrey V., additional

Published
2018
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65. Frozen-Ground Cartoons: An international collaboration between artists and permafrost scientists

Author

Sjöberg, Ylva, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Rudy, Ashley, Siewert, Matthias Benjamin, Veillete, Audrey, Weege, Stefanie, Habeck, J. O., Harbor, John, Sjöberg, Ylva, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Rudy, Ashley, Siewert, Matthias Benjamin, Veillete, Audrey, Weege, Stefanie, Habeck, J. O., and Harbor, John

Abstract

Communicating science about a phenomenon found under ground and defined by its thermal properties in an easy, fun, and engaging way, can be a challenge. Two years ago, a group of young researchers from Canada and Europe united to tackle this problem by combining arts and science to produce a series of outreach comic strips about permafrost (frozen ground). Because this concerns us all. As the climate warms, permafrost thaws and becomes unstable for houses, roads and airports.The thawing also disrupts ecosystems, impacts water quality, and releases greenhouse gases into the atmosphere, making climate change even stronger. The Frozen Ground Cartoon project aims to present and explain permafrost research, placing emphasis on field work and the rapidly changing northern environment. The target audience is kids, youth, parents and teachers, with the general goal of making permafrost science more fun and accessible to the public. The project has so far produced 22 pages of comics through an iterative process of exchanging ideas between two artists and thirteen scientists. The project artists were selected through an application call that received 49 applications from artists in 16 countries. With input from scientists, artists Noémie Ross (Canada) and Heta Nääs (Finland) have created a set of beautiful, artistic, humoristic, and pedagogic comics.. The comics are available for free download through the project web page (in English and Swedish), and printed copies have so far been handed out to school kids and general public in Europe. Prints in North America are planned for the fall of 2017. The next steps of the project are (1) to distribute the comics as wide as possible, (2) work towards translations into more languages, and (3) to evaluate the effectiveness of the science communication through the comics, in collaboration with schools and pedagogic experts.

Published
2017

66. Permafrost Comics: Bridging the gap between science and society

Author

Paquette, Michel, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Rudy, Ashley, Siewert, Matthias Benjamin, Sjöberg, Ylva, Veillete, Audrey, Harbor, John, Weege, Stefanie, Paquette, Michel, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Rudy, Ashley, Siewert, Matthias Benjamin, Sjöberg, Ylva, Veillete, Audrey, Harbor, John, and Weege, Stefanie

Abstract

The “Frozen-Ground Cartoons” IPA Action Group has teamed up with artists Noémie Ross and Heta Nääs to come up with a series of entertaining comics aimed mainly at youth, but relevant to the general public. The comics focus on permafrost, permafrost research and the effects of climate change on northern communities and wildlife. The topics surrounding permafrost research have recently been evolving, garnering an interest to frozen-ground sensitivity and behaviour that extends beyond scientific researchers and organizations. The expression “permafrost is melting” (sic) now pops up frequently in the news, with such phenomena as “methane explosions” and “permafrost landslides” elevated to the honorable rank of click-baits on social media newsfeeds. While “permafrost” is a word now recognized by many, it is still a challenge to demystify the Arctic environment and the work that is done by researchers on this topic. The “Frozen-Ground Cartoons” address this gap between scientists and the public and are available as printed booklets (free giveaways at the poster!) and free public downloads of the comics on the website frozengroundcartoon.com. Available in English, the comics are to be translated in many languages in the near future, including northern native languages. This project was initiated exclusively from early career researchers who built on the networking opportunities of large projects such as ADAPT and PAGE21, as well as from the Arctic early career researcher groups APECS and PYRN. It is of great interest to every researcher, as outreach is now an important part of the work of scientists. The framework could also be applied to other disciplines, and we strongly hope this project can serve as an inspiration to budding outreach specialists across the ArcticNet community.

Published
2017

67. Frozen-Ground Cartoons: An international collaboration between artists and permafrost scientists

Author

Nääs, Heta, Ross, Noémie, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Siewert, Matthias Benjamin, Sjöberg, Ylva, Veillete, Audrey, Weege, Stefanie, Harbor, John, Habeck, J. O., Nääs, Heta, Ross, Noémie, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Siewert, Matthias Benjamin, Sjöberg, Ylva, Veillete, Audrey, Weege, Stefanie, Harbor, John, and Habeck, J. O.

Abstract

This project started in October 2015 with a crazy idea: prepare and submit a funding application for an international, multidisciplinary and non-traditional scientific outreach project… within the next 48 hours. Well, it worked out. A group of highly motivated young researchers from Canada and Europe united to combine arts and science and produce a series of outreach comic strips about permafrost (frozen ground). The aim of the project is to present and explain scientific research conducted across the circumpolar Arctic, placing emphasis on field work and the rapidly changing northern environment. The target audience is kids, youth, parents and teachers, with the general goal of making permafrost science more fun and accessible to the public. Because guess what : permafrost represents an area of more than twenty million km2 in the Northern Hemisphere, a huge area. As the climate warms, permafrost thaws and becomes unstable for houses, roads and airports. This rapid thawing of previously frozen ground also disrupts plant and animal habitats, impacts water quality and the ecology of lakes, and releases carbon into the atmosphere as greenhouse gases, making climate change even stronger. Hence permafrost and its response to climate change concerns us all. The project received initial support from the International Permafrost Association (IPA) as a targeted ‘Action Group’, and since then several other sponsors have joined the project. Here we are, now, two years after this first idea. What you are about to read is the result of an iterative process of exchanging ideas between artists and scientists. We first made an application call and received 49 applications from artists in 16 countries. Through a formal review process, we then selected two artists to work on this project: Noémie Ross from Canada, and Heta Nääs from Finland. With input from scientists, Noémie and Heta created fantastic cartoons that explain some of the changes happening to the environment in permafros

Published
2017

68. A Frozen-Ground Cartoon: Explaining international permafrost research using comic strips

Author

Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Paquette, Michel, Rudy, Ashley, Siewert, Matthias, Sjöberg, Ylva, Veillete, Audrey, Harbor, John, Weege, Stefanie, Ross, Noémie, and Nääs, Heta

Abstract

Apart from people in cold region communities and a small – although steadily growing – scientific community, the general public knows very little about permafrost properties, its dynamics in response to climate change, and the research going on in the field. We are addressing this by making permafrost science accessible to children, youth, their parents, and teachers. We are producing a 100% outreach-related project that aims at ‘Fostering permafrost research to the ends of the Earth’ (http://ipa.arcticportal.org), but with a casual approach via a series of comic strips. Cartoons are excellent ways to communicate messages in today’s media landscape: they are graphic, funny and direct, and can be rapidly shared via social media to reach many people. Our outreach project targets the general public, focusing on young students who have to choose career paths at the high school or college levels. By introducing them to permafrost research activities, particularly fieldwork, our ‘Frozen-Ground Cartoon’ will enhance the dissemination of permafrost knowledge and broaden the international community of permafrost ‘lovers’. This new project is coordinated by a core group of permafrost early career researchers from Canada, Germany, Sweden and Portugal (in collaboration with an ‘external senior advisor’), and is endorsed by the International Permafrost Association (IPA) as a targeted ‘Action Group’ (http://ipa.arcticportal.org/activities/action-groups). Here we present an overview of our Action Group, including main objectives, significance, and potential future outcomes.

Published
2016

69. The future of permafrost research: a contribution from early career researchers to ICARP III and beyond

Author

Morgenstern, Anne, Fritz, Michael, Deshpande, Bethany, Bouchard, Fréderic, Högström, Elin, Malenfant-Lepage, Julie, Nieuwendam, Alexandre, Oliva, Marc, Paquette, Michel, Rudy, Ashley, Siewert, Matthias, Sjöberg, Ylva, and Weege, Stefanie

Abstract

Over the past two decades, the International Arctic Science Committee (IASC) and the Scientific Committee on Antarctic Research (SCAR) have organized activities focused on international and interdisciplinary perspectives for advancing Arctic and Antarctic research cooperation and knowledge dissemination in many areas (e.g. Kennicutt et al., 2014). For permafrost science, however, no consensus document exists at the international level to identify future research priorities, although the International Permafrost Association (IPA) highlighted the need for such a document during the 10th International Conference on Permafrost in 2012. Four years later, this presentation, which is based on the results obtained by Fritz et al. (2015), outlines the outcome of an international and interdisciplinary effort conducted by early career researchers (ECRs). This effort was designed as a contribution to the Third International Conference on Arctic Research Planning (ICARP III). In June 2014, 88 ERCs convened during the Fourth European Conference on Permafrost to identify future priorities for permafrost research. We aimed to meet our goals of hosting an effective large group dialogue by means of online question development followed by a “World Café” conversational process. An overview of the process is provided in Figure 1. This activity was organized by the two major early career researcher associations Permafrost Young Researchers’ Network (PYRN) and the Association of Polar Early career Scientists (APECS), as well as the regional research projects PAGE21 (EU) and ADAPT (Canada). Participants were provided with live instructions including criteria regarding what makes a research question (Sutherland et al., 2011). The top five questions that emerged from this process are: (1) How does permafrost degradation affect landscape dynamics at different spatial and temporal scales? (2) How can ground thermal models be improved to better reflect permafrost dynamics at high spatial resolution? (3) How can traditional environmental knowledge be integrated in permafrost research? (4) What is the spatial distribution of different ground-ice types and how susceptible is ice-rich permafrost to future environmental change? (5) What is the influence of infrastructures on the thermal regime and stability of permafrost in different environmental settings? As the next generation of permafrost researchers, we see the need and the opportunity to participate in framing the future research priorities. Across the polar sciences, ECRs have built powerful networks, such as the Association of Polar Early Career Scientists (APECS) and the Permafrost Young Researchers Network (PYRN), which have enabled us to efficiently consult with the community. Many participants of this community-input exercise will be involved in and also affected by the Arctic science priorities during the next decade. Therefore, we need to (i) contribute our insights into larger efforts of the community such as the Permafrost Research Priorities initiative by the Climate and Cryosphere (CliC) project together with the IPA and (ii) help identify relevant gaps and a suitable roadmap for the future of Arctic research. Critical evaluation of the progress made since ICARP II and revisiting the science plans and recommendations will be crucial. IASC and the IPA, together with SCAR on bipolar activities, should coordinate the research agendas in a proactive manner engaging all partners, including funding agencies, policy makers, and local communities. Communicating our main findings to society in a dialogue between researchers and the public is a priority. Special attention must be given to indigenous peoples living on permafrost, where knowledge exchange creates a mutual benefit for science and local communities. The ICARP III process is an opportunity to better communicate the global importance of permafrost to policy makers and the public.

Published
2016

70. 18Th European Symposium On Radiopharmacy And Radiopharmaceuticals

Author

Radchenko, V., Engle, J. W., Roy, C., Griswold, J., Nortier, M. F., Birnbaum, E. R., Brugh, M., Mirzadeh, S., John, K. D., Fassbender, M. E., Zhai, Chuangyan, Franssen, Gerben M., Petrik, Milos, Laverman, Peter, Decristoforo, Clemens, Samia, Ait-Mohand, Véronique, Dumulon-Perreault, Brigitte, Guérin, Summer, D., Kroess, A., Rangger, C., Haas, H., Laverman, P., Gerben, F., von Guggenberg, E., Decristoforo, C., Bolzati, Cristina, Salvarese, Nicola, Refosco, Fiorenzo, Meléndez-Alafort, Laura, Carpanese, Debora, Rosato, Antonio, Saviano, Michele, Del Gatto, Annarita, Comegna, Daniela, Zaccaro, Laura, Billaud, Emilie, Ahamed, Muneer, Cleeren, Frederik, Shahbazali, Elnaz, Noël, Tim, Hessel, Volker, Verbruggen, Alfons, Bormans, Guy, Cleeren, F., Lecina, J., Koole, M., Verbruggen, A., Bormans, G., Lugatoa, B., Stucchia, S., Turollaa, E. A., Giulianoa, L., Toddea, S., Ferraboschib, P., Klok, R. P., Mooijer, M. P. J., Hendrikse, N. H., Windhorst, A. D., Collet, C., Petry, N., Chrétien, F., Karcher, G., Pellegrini-Moïse, N., Lamandé-Langle, S., Pfaff, Sarah, Philippe, Cecile, Mitterhauser, Markus, Hacker, Marcus, Wadsak, Wolfgang, Guérard, François, Lee, Yong-Sok, Gouard, Sébastien, Baidoo, Kwamena, Alliot, Cyrille, Chérel, Michel, Brechbiel, Martin W., Gestin, Jean-François, Lam, K., Chan, C., Reilly, R. M., Paillas, Salomé, Marshall, John, Pouget, Jean-Pierre, Sosabowski, Jane, Briard, Emmanuelle, Auberson, Yves P., Reilly, John, Healy, Mark, Sykes, David, Paulus, Andreas, Lichtenbelt, Wouter van Marken, Mottaghy, Felix, Bauwens, Matthias, Baranski, Ann-Christin, Schäfer, Martin, Bauder-Wüst, Ulrike, Haberkorn, Uwe, Eder, Matthias, Kopka, Klaus, Chaussard, M., Hosten, B., Vignal, N., Tsoupko-Sitnikov, V., Hernio, N., Hontonnou, F., Merlet, P., Poyet, J. L., Sarda-Mantel, L., Rizzo-Padoin, N., Cardinale, J., Schäfer, M., Benešová, M., Bauder-Wüst, U., Seibert, O., Giesel, F., Haberkorn, U., Eder, M., Kopka, K., Nematallah, Mansour, Michel, Paquette, Roger, Lecomte, Fernandez-Maza, L., Rivera-Marrero, S., Capote, A. Prats, Parrado-Gallego, A., Fernandez-Gomez, I., Balcerzyk, M., Sablon-Carrazana, M., Perera-Pintado, A., Merceron-Martinez, D., Acosta-Medina, E., Rodriguez-Tanty, C., Attili, Bala, Philippe, C., Zeilinger, M., Scherer, T., Fürnsinn, C., Dumanic, M., Wadsak, W., Hacker, M., Mitterhauser, M., Janssen, B., Vugts, D. J., Molenaar, G.T. T., Funke, U., Kruijer, P. S., Dollé, F., Lammertsma, A. A., Vermeulen, Koen, Schnekenburger, Michael, Froeyen, Mathy, Olberg, Dag Erlend, Diederich, Marc, Bormansa, Guy, Raaphorst, R. M., Luurtsema, G., Elsinga, P. H., Windhorst, A D., Rotteveel, Lonneke, Funke, Uta, ten Dijke, Peter, Bogaard, Harm Jan, Lammertsma, Adriaan A., Windhorst, Albert D., Song, Lei, Able, Sarah, Falzone, Nadia, Kersemans, Veerle, Vallis, Katherine, Carta, Davide, Sihver, Wiebke, Gao, Feng, Pietzsch, Hans Jürgen, Biondi, Barbara, Ruzza, Paolo, Haubner, Roland, Finkensted, Armin, Stegmair, Armin, Rangger, Christine, Zoller, Heinz, Virgolini, Irene J., Pooters, Ivo, Lotz, Maartje, Wierts, Roel, Forsback, Sarita, Jörgen, Bergman, Riikka, Kivelä, Karageorgou, M., Radović, M., Tsoukalas, C., Antic, B., Gazouli, M., Paravatou-Petsotas, M., Xanthopouls, S., Calamiotou, M., Stamopoulos, D., Vranješ-Durić, S., Bouziotis, P., Lunev, A. S., Larenkov, A. A., Petrosova, K. A., Klementyeva, O. E., Kodina, G. E., Kvernenes, O. H., Adamsen, T. C. H., Martin, René, Weidlich, Sebastian, Zerges, Anna-Maria, Gameiro, Cristiana, Lazarova, Neva, Müllera, Marco, Luurtsema, Gert, de Vries, Michèl, Ghyoot, Michel, van der Woude, Gina, Zijlma, Rolf, Dierckx, Rudi, Boersma, Hendrikus H., Elsinga, Philip H., Lambrecht, Fatma Yurt, Er, Ozge, Ince, Mine, Avci, Cıgır Biray, Gunduz, Cumhur, Sarı, Fatma Aslihan, Ocakoglu, Kasim, Ersoz, Onur Alp, Kayabasi, Cagla, Kniess, Torsten, Meister, Sebastian, Fischer, Steffen, Steinbach, Jörg, Ashfaq, Rabia, Iqbal, Saeed, ullah Khan, Irfan, Iglesias-Jerez, R., Martín-Banderas, L., Borrego-Dorado, I., Farinha-Antunes, Ines, Kwizera, Chantal, Lacivita, Enza, Lucente, Ermelinda, Niso, Mauro, De Giorgio, Paola, Perrone, Roberto, Colabufo, Nicola A., Leopoldo, Marcello, Vaulina, V. V., Fedorova, O. S., Orlovskaja, V. V., Chen, С. L., Li, G. Y., Meng, F. C., Liu, R. S., Wang, H. E., Krasikova, R. N., Abozeid, Mohamed, Ferro-Flores, Guillermina, Negri, Anna, Bello, Michele, Uzunov, Nikolay, Paiusco, Martha, Esposito, Juan, Palmieri, L., Verbrugghen, T., Glassner, M., Hoogenboom, R., Staelens, S., Wyffels, L., Kuznetsova, O. F., Maleev, V. I., Belokon, Yu. N., Geolchanyan, A., Saghyan, A. S., Mu, L., Schibli, R., Ametamey, S. M., Revunov, Evgeny, Malmquist, Jonas, Johnström, Peter, Van Valkenburgh, Juno, Steele, Dalton, Halldin, Christer, Schou, Magnus, Osati, Samira, Paquette, Michel, Beaudoin, Simon, Ali, Hasrat, Guerin, Brigitte, Leyton, Jeffrey V., van Lier, Johan E., Di Iorio, V, Iori, M., Donati, C., Lanzetta, V., Capponi, P. C., Rubagotti, S., Dreger, T., Kunkel, F., Asti, M., Summer, Dominik, Haas, Hubertus, Kijprayoon, Suphansa, Ruangma, Ananya, Ngokpol, Suthatip, Tuamputsha, Samart, Filp, Ulrike, Pees, Anna, Taddei, Carlotta, Pekošak, Aleksandra, Gee, Antony D., Poot, Alex J., Gunay, Mine Silindir, Ozer, A. Yekta, Erdogan, Suna, Baysal, Ipek, Guilloteau, Denis, Chalon, Sylvie, Galli, Filippo, Artico, Marco, Taurone, Samanta, Bianchi, Enrica, Weintraub, Bruce D., Skudlinski, Mariusz, Signore, Alberto, Lepareur, Nicolas, Noiret, Nicolas, Hindré, François, Lacœuille, Franck, Benoist, Eric, Garin, Etienne, Trejo-Ballado, F., Zamora-Romo, E., Manrique-Arias, J. C., Gama-Romero, H M, Contreras-Castañon, G., Tecuapetla-Chantes, R. G., Avila-Rodriguez, M. A., Kvaternik, H., Hausberger, D., Zink, C., Rumpf, B., Aigner, R. M., Janković, Drina, Lakić, Mladen, Savić, Aleksandar, Ristić, Slavica, Nikolić, Nadežda, Vukadinović, Aleksandar, Sabo, Tibor J., Vranješ-Đurić, Sanja, Vranješ-Đurić, S., Janković, D., Nikolić, N., Goya, G. F., Calatayud, P., Spasojević, V., Antić, B., Goblet, David, Oxley, Ian, Abrunhosa, Antero, Kramer, Vasko, Vosjan, Maria, Spaans, Arnold, Vats, Kusum, Satpati, Drishty, Sarma, Haladhar D., Banerjee, Sharmila, Wojdowska, W., Pawlak, D. W., Parus, L. J., Garnuszek, P., Mikołajczak, R., Pijarowska-Kruszyna, J., Jaron, A., Kachniarz, A., Malkowski, B., Mikolajczak, R., Ilem-Ozdemir, Derya, Caglayan-Orumlu, Oya, Asikoglu, Makbule, Eveliina, Arponen, Semi, Helin, Timo, Saarinen, Simo, Vauhkala, Esa, Kokkomäki, Pertti, Lehikoinen, De Simone, Mariarosaria, Pascali, Giancarlo, Carzoli, Ludovica, Quaglierini, Mauro, Telleschi, Mauro, Salvadori, Piero A., Lam, Phoebe, Aistleitner, Martina, Eichinger, Reinhard, Artner, Christoph, Nakka, Surendra, MC, Hemantha Kumara, Al-Qahtani, Mohammed, Al-Malki, Yousif, Mambilima, N., Rubow, S. M., Berroterán-Infante, N., Lecina, Joan, Gallardo, Rodrigo, Verbruggen, Alfons M., Ramos-Membrive, Rocío, Brotons, Ana, Quincoces, Gemma, Inchaurraga, Laura, de Redín, Inés Luis, Morán, Verónica, García-García, Berta, Irache, Juan Manuel, Peñuelas, Iván, Trabelsi, M., Cooper, M. S., Abella, Alejandra, Fuente, Teodomiro, Montellano, Antonio Jesús, Martínez, Teresa, Rabadan, Ruben, Meseguer-Olmo, Luis, Lehtiniemi, P., Yim, C., Mikkola, K., Nuutila, P., Solin, O., Mair, C., Balogh, L., Pöstényi, Z., Pawlak, D., Socan, A., Peitl, P. Kolenc, Krošelj, M., Remy, S., Didier, R., Vergote, T., Véran, N., Maurin, M., Karczmarczyk, U., Fredericia, Pil, Severin, Gregory, Groesser, Torsten, Köster, Ulli, Jensen, Mikael, Leonte, R., Puicea, F. D., Raicu, A., Min, E. A., Serban, R., Manda, G., Niculae, D., Zerna, Marion, Schieferstein, Hanno, Müller, Andre, Berndt, Mathias, Yim, Cheng-Bin, Mikkola, Kirsi, Nuutila, Pirjo, Solin, Olof, Seifert, D., Ráliš, J., Lebeda, O., Selivanova, Svetlana V., Senta, Helena, Lavallée, Éric, Caouette, Lyne, Turcotte, Éric, Lecomte, Roger, Kochovska, Marina Zdraveska, Ivanovska, Emilija Janjevik, Jokic, Vesna Spasic, Ackova, Darinka Gjorgieva, Smilkov, Katarina, Makreski, Petre, Stafilov, Trajče, Janevik-Ivanovska, Emilija, Alemu, Aschalew, Muchira, Joel Munene, Wanjeh, David Mwanza, Zdravev, Zoran, Bhonsle, Uday, Alberto, Osso Júnior João, Duatti, Adriano, Angelovska, Bistra, Stojanovska, Zdenka, Sarafinovska, Zorica Arsova, Bosnakovski, Darko, Gorgieva-Ackova, Darinka, Drakalska, Elena, Venkatesh, Meera, Gulaboski, Rubin, Colin, Didier J., Inkster, James A. H., Germain, Stéphane, Seimbille, Yann, and Radyofarmasi

Subjects
Meeting Abstracts
Abstract

OP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targets, V. Radchenko, J.W. Engle, C. Roy, J. Griswold, M.F. Nortier, E.R. Birnbaum, M. Brugh, S. Mirzadeh, K. D. John, M.E. Fassbender, OP04 Comparison of [68Ga]FSC(succ-RGD)3 and [68Ga]NODAGA-RGD for PET imaging of αvβ3 integrin expression, Chuangyan Zhai, Gerben M. Franssen, Milos Petrik, Peter Laverman, Clemens Decristoforo, OP05 A new NPY-Y1R targeting peptide for breast cancer PET imaging, Ait-Mohand Samia, Dumulon-Perreault Véronique, Guérin Brigitte, OP06 The influence of multivalency on CCK 2 receptor targeting, D. Summer, A. Kroess, C. Rangger, H. Haas, P. Laverman, F. Gerben, E. von Guggenberg, C.Decristoforo, OP07 SPECT Imaging of αvβ3 Expression by [99mTc(N)PNP43]- Bifunctional Chimeric RGD Peptide not Cross-Reacting with αvβ5, Cristina Bolzati, Nicola Salvarese, Fiorenzo Refosco, Laura Meléndez-Alafort, Debora Carpanese, Antonio Rosato, Michele Saviano, Annarita Del Gatto, Daniela Comegna, Laura Zaccaro, OP09 New dienophiles for the inverse-electron-demand Diels-Alder reaction and for pretargeted PET imaging, Emilie Billaud, Muneer Ahamed, Frederik Cleeren, Elnaz Shahbazali, Tim Noël, Volker Hessel, Alfons Verbruggen and Guy Bormans, OP10 New complexing agent for Al18F-labelling of heat-sensitive biomolecules: Synthesis and preclinical evaluation of Al18F-RESCA1-HAS, Cleeren F, Lecina J, Koole M, Verbruggen A and Bormans G, OP11 A novel versatile precursor efficient for F-18 radiolabelling via click-chemistry, B. Lugatoa, S. Stucchia, E.A. Turollaa, L. Giulianoa, S.Toddea, P. Ferraboschib, OP12 A general applicable method to quantify unidentified UV impurities in radiopharmaceuticals, R.P. Klok, M.P.J. Mooijer, N.H. Hendrikse, A.D. Windhorst, OP13 Development of [18F]Fluoro-C-glycosides to radiolabel peptides, Collet C., Petry N., Chrétien F., Karcher G., Pellegrini-Moïse N., Lamandé-Langle S., OP14 A Microfluidic Approach for the 68Ga-labeling of PSMAHBED-CC and NODAGA-RGD, Sarah Pfaff, Cecile Philippe, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak, OP16 Surprising reactivity of astatine in the nucleophilic substitution of aryliodonium salts: application to the radiolabeling of antibodies, François Guérard, Yong-Sok Lee, Sébastien Gouard, Kwamena Baidoo, Cyrille Alliot, Michel Chérel, Martin W. Brechbiel, Jean-François Gestin, OP17 64Cu-NOTA-pertuzumab F(ab')2 fragments, a second-generation probe for PET imaging of the response of HER2-positive breast cancer to trastuzumab (Herceptin), Lam K, Chan C, Reilly RM, OP18 Development of radiohalogenated analogues of a avb6-specific peptide for high LET particle emitter targeted radionuclide therapy of cancer, Salomé Paillas, John Marshall, Jean-Pierre Pouget, Jane Sosabowski, OP19 Ligand Specific Efficiency (LSE) as a guide in tracer optimization, Emmanuelle Briard, Yves P. Auberson, John Reilly, Mark Healy, David Sykes, OP23 The radiosynthesis of an 18F-labeled triglyceride, developed to visualize and quantify brown adipose tissue activity, Andreas Paulus, Wouter van Marken Lichtenbelt,Felix Mottaghy, Matthias Bauwens, OP24 Influence of the fluorescent dye on the tumor targeting properties of dual-labeled HBED-CC based PSMA inhibitors, Baranski, Ann-Christin, Schäfer, Martin, Bauder-Wüst, Ulrike, Haberkorn, Uwe, Eder, Matthias, Kopka, Klaus, OP25 [18F]MEL050 as a melanin PET tracer : fully automated radiosynthesis and evaluation for the detection of pigmented melanoma in mice pulmonary metastases, Chaussard M, Hosten B, Vignal N, Tsoupko-Sitnikov V, Hernio N, Hontonnou F, Merlet P, Poyet JL, Sarda-Mantel L, Rizzo-Padoin N, OP26 Design and Preclinical Evaluation of Novel Radiofluorinated PSMA Targeting Ligands Based on PSMA-617, J. Cardinale, M. Schäfer, M. Benešová, U. Bauder-Wüst, O. Seibert, F. Giesel, U. Haberkorn, M. Eder, K. Kopka, OP27 A novel radiolabeled peptide for PET imaging of prostate cancer: 64Cu-DOTHA2-PEG-RM26, Mansour Nematallah, Paquette Michel, Ait-Mohand Samia, Dumulon-Perreault Véronique, Lecomte Roger, Guérin Brigitte, OP29 Biodistribution of [18F]Amylovis®, a new radiotracer PET imaging of β-amyloid plaques, Fernandez-Maza L, Rivera-Marrero S, Prats Capote A, Parrado-Gallego A, Fernandez-Gomez I, Balcerzyk M, Sablon-Carrazana M, Perera-Pintado A, Merceron-Martinez D, Acosta-Medina E, Rodriguez-Tanty C, OP30 Synthesis and preclinical evaluation of [11C]-BA1 PET tracer for the imaging of CSF-1R, Bala Attili, Muneer Ahamed, Guy Bormans, OP31 In vivo imaging of the MCHR1 in the ventricular system via [18F]FE@SNAP, C. Philippe, M. Zeilinger, T. Scherer, C. Fürnsinn, M. Dumanic, W. Wadsak, M. Hacker, M. Mitterhauser, OP32 Synthesis of the first carbon-11 labelled P2Y12 receptor antagonist for imaging the anti-inflammatory phenotype of activated microglia, B. Janssen, D.J. Vugts, G.T. Molenaar, U. Funke, P.S. Kruijer, F. Dollé, G. Bormans, A.A. Lammertsma, A.D. Windhorst, OP33 Radiosynthesis of a selective HDAC6 inhibitor [11C]KB631 and in vitro and ex vivo evaluation, Koen Vermeulen, Muneer Ahamed, Michael Schnekenburger, Mathy Froeyen, Dag Erlend Olberg, Marc Diederich, Guy Bormansa, OP34 Improving metabolic stability of fluorine-18 labelled verapamil analogues, Raaphorst RM, Luurtsema G, Lammertsma AA, Elsinga PH, Windhorst AD, OP36 Development of a novel PET tracer for the activin receptor-like kinase 5, Lonneke Rotteveel, Uta Funke, Peter ten Dijke, Harm Jan Bogaard, Adriaan A. Lammertsma, Albert D. Windhorst, OP37 SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo, Lei Song, Sarah Able, Nadia Falzone, Veerle Kersemans, Katherine Vallis, OP38 Melanoma targeting with [99mTc(N)(PNP3)]-labeled NAPamide derivatives: preliminary pharmacological studies, Davide Carta, Nicola Salvarese, Wiebke Sihver, Feng Gao, Hans Jürgen Pietzsch, Barbara Biondi, Paolo Ruzza, Fiorenzo Refosco, Cristina Bolzati, OP39 [68Ga]NODAGA-RGD: cGMP synthesis and data from a phase I clinical study, Roland Haubner, Armin Finkensted, Armin Stegmair, Christine Rangger, Clemens Decristoforo, Heinz Zoller, Irene J. Virgolin, OP44 Implementation of a GMP-grade radiopharmacy facility in Maastricht, Ivo Pooters, Maartje Lotz, Roel Wierts, Felix Mottaghy, Matthias Bauwens, OP45 Setting up a GMP production of a new radiopharmaceutical, Forsback, Sarita, Bergman Jörgen, Kivelä Riikka, OP48 In vitro and in vivo evaluation of 68-gallium labeled Fe3O4-DPD nanoparticles as potential PET/MRI imaging agents, M. Karageorgou, M. Radović, C. Tsoukalas, B. Antic, M. Gazouli, M. Paravatou-Petsotas, S. Xanthopouls, M. Calamiotou, D. Stamopoulos, S. Vranješ-Durić, P. Bouziotis, OP49 Fast PET imaging of inflammation using 68Ga-citrate with Fe-containing salts of hydroxy acids, A. S. Lunev, A. A. Larenkov, K.A. Petrosova, O. E. Klementyeva, G. E. Kodina, PP01 Installation and validation of 11C-methionine synthesis, Kvernenes, O.H., Adamsen, T.C.H., PP02 Fully automated synthesis of 68Ga-labelled peptides using the IBA Synthera® and Synthera® Extension modules, René Martin, Sebastian Weidlich, Anna-Maria Zerges, Cristiana Gameiro, Neva Lazarova, Marco Müllera, PP03 GMP compliant production of 15O-labeled water using IBA 18 MeV proton cyclotron, Gert Luurtsema, Michèl de Vries, Michel Ghyoot, Gina van der Woude, Rolf Zijlma, Rudi Dierckx, Hendrikus H. Boersma, Philip H. Elsinga, PP04 In vitro Nuclear Imaging Potential of New Subphthalocyanine and Zinc Phthalocyanine, Fatma Yurt Lambrecht, Ozge Er, Mine Ince, Cıgır Biray Avci, Cumhur Gunduz, Fatma Aslihan Sarı, PP05 Synthesis, Photodynamic Therapy Efficacy and Nuclear Imaging Potential of Zinc Phthalocyanines, Kasim Ocakoglu, Ozge Er, Onur Alp Ersoz, Fatma Yurt Lambrecht, Mine Ince, Cagla Kayabasi, Cumhur Gunduz, PP06 Radio-U(H)PLC – the Search on the Optimal Flow Cell for the γ-Detector, Torsten Kniess, Sebastian Meister, Steffen Fischer, Jörg Steinbach, PP07 Radiolabeling, characterization & biodistribution study of cysteine and its derivatives with Tc99m, Rabia Ashfaq, Saeed Iqbal, Atiq-ur-Rehman, Irfan ullah Khan, PP08 Radiolabelling of poly (lactic-co.glycolic acid) (PLGA) nanoparticles with 99mTC, R Iglesias-Jerez, Cayero-Otero, L. Martín-Banderas, A. Perera-Pintado, I. Borrego-Dorado, PP09 Development of [18F]PD-410 as a non-peptidic PET radiotracer for gastrin releasing peptide receptors, Ines Farinha-Antunes, Chantal Kwizera, Enza Lacivita, Ermelinda Lucente, Mauro Niso, Paola De Giorgio, Roberto Perrone, Nicola A. Colabufo, Philip H. Elsinga, Marcello Leopoldo, PP10 An improved nucleophilic synthesis of 2-(3,4-dimethoxyphenyl)-6-(2-[18F]fluoroethoxy) benzothiazole ([18F]FEDMBT), potential diagnostic agent for breast cancer imaging by PET, V.V. Vaulina, O.S. Fedorova, V.V. Orlovskaja, ?�.L. Chen, G.Y. Li, F.C. Meng, R.S. Liu, H.E. Wang, R.N. Krasikova, PP11 Internal radiation dose assessment of radiopharmaceuticals prepared with accelerator-produced 99mTc, Laura Meléndez-Alafort, Mohamed Abozeid, Guillermina Ferro-Flores, Anna Negri, Michele Bello, Nikolay Uzunov, Martha Paiusco, Juan Esposito, Antonio Rosato, PP12 A specialized five-compartmental model software for pharmacokinetic parameters calculation, Laura Meléndez-Alafort, Cristina Bolzati, Guillermina Ferro-Flores, Nicola Salvarese, Debora Carpanese, Mohamed Abozeid, Antonio Rosato, Nikolay Uzunov, PP13 Molecular imaging of the pharmacokinetic behavior of low molecular weight 18F-labeled PEtOx in comparison to 89Zr-labeled PEtOx, Palmieri L, Verbrugghen T, Glassner M, Hoogenboom R, Staelens S, Wyffels L, PP14 Towards nucleophilic synthesis of the α-[18F]fluoropropyl-L-dihydroxyphenylalanine, V. V. Orlovskaja, O. F. Kuznetsova, O. S. Fedorova, V. I. Maleev, Yu. N. Belokon, A. Geolchanyan, A. S. Saghyan, L. Mu, R. Schibli, S. M. Ametamey, R. N. Krasikova, PP15 A convenient one-pot synthesis of [18F]clofarabine, Revunov, Evgeny, Malmquist, Jonas, Johnström, Peter, Van Valkenburgh, Juno, Steele, Dalton, Halldin, Christer, Schou, Magnus, PP16 BODIPY-estradiol conjugates as multi-modality tumor imaging agents, Samira Osati,Michel Paquette,Simon Beaudoin,Hasrat Ali,Brigitte Guerin, Jeffrey V. Leyton, Johan E. van Lier, PP17 Easy and high yielding synthesis of 68Ga-labelled HBED-PSMA and DOTA-PSMA by using a Modular-Lab Eazy automatic synthesizer, Di Iorio V, Iori M, Donati C, Lanzetta V, Capponi PC, Rubagotti S, Dreger T, Kunkel F, Asti M, PP18 Synthesis and evaluation of fusarinine C-based octadentate bifunctional chelators for zirconium-89 labelling, Chuangyan Zhai, Christine Rangger, Dominik Summer, Hubertus Haas, Clemens Decristoforo, PP19 Fully automated production of [18F]NaF using a re-configuring FDG synthesis module., Suphansa Kijprayoon, Ananya Ruangma, Suthatip Ngokpol, Samart Tuamputsha, PP20 Extension of the Carbon-11 Small Labeling Agents Toolbox and Conjugate Addition, Ulrike Filp, Anna Pees, Carlotta Taddei, Aleksandra Pekošak, Antony D. Gee, Alex J. Poot, Albert D. Windhorst, PP21 In vitro studies on BBB penetration of pramipexole encapsulated theranostic liposomes for the therapy of Parkinson’s disease, Mine Silindir Gunay, A. Yekta Ozer, Suna Erdogan, Ipek Baysal, Denis Guilloteau, Sylvie Chalon, PP22 Factors affecting tumor uptake of 99mTc-HYNIC-VEGF165, Filippo Galli, Marco Artico, Samanta Taurone, Enrica Bianchi, Bruce D. Weintraub, Mariusz Skudlinski, Alberto Signore, PP23 Rhenium-188: a suitable radioisotope for targeted radiotherapy, Nicolas Lepareur, Nicolas Noiret, François Hindré, Franck Lacœuille, Eric Benoist, Etienne Garin, PP24 Preparation of a broad palette of 68Ga radiopharmaceuticals for clinical applications, Trejo-Ballado F, Zamora-Romo E, Manrique-Arias JC, Gama-Romero HM, Contreras-Castañon G, Tecuapetla-Chantes RG, Avila-Rodriguez MA, PP25 68Ga-peptide preparation with the use of two 68Ge/68Ga-generators, H. Kvaternik, D. Hausberger, C. Zink, B. Rumpf, R. M. Aigner, PP26 Assay of HEPES in 68Ga-peptides by HPLC, H. Kvaternik, D. Hausberger, B. Rumpf, R. M. Aigner, PP27 Preparation, in vitro and in vivo evaluation of a 99mTc(I)-Diethyl Ester (S,S)-Ethylenediamine- N,N´-DI-2-(3-Cyclohexyl) Propionic acid as a target-specific radiopharmaceutical, Drina Janković, Mladen Lakić, Aleksandar Savić, Slavica Ristić, Nadežda Nikolić, Aleksandar Vukadinović, Tibor J. Sabo, Sanja Vranješ-Đurić, PP28 90Y-labeled magnetite nanoparticles for possible application in cancer therapy, S. Vranješ-Đurić, M. Radović, D. Janković, N. Nikolić, G. F. Goya, P. Calatayud, V. Spasojević, B. Antić, PP29 Simplified automation of the GMP production of 68Ga-labelled peptides, David Goblet, Cristiana Gameiro, Neva Lazarova, PP30 Combining commercial production of multi-products in a GMP environment with Clinical & R&D activities, Cristiana Gameiro, Ian Oxley, Antero Abrunhosa, Vasko Kramer, Maria Vosjan, Arnold Spaans, PP31 99mTc(CO)3-labeling and Comparative In-Vivo Evaluation of Two Clicked cRGDfK Peptide Derivatives, Kusum Vats, Drishty Satpati, Haladhar D Sarma, Sharmila Banerjee, PP32 Application of AnaLig resin for 99mTc separation from molybdenum excess, Wojdowska W., Pawlak D.W., Parus L. J., Garnuszek P., Mikołajczak R., PP33 Constraints for selection of suitable precursor for one-step automated synthesis of [18F]FECNT, the dopamine transporter ligand, Pijarowska-Kruszyna J, Jaron A, Kachniarz A, Malkowski B, Garnuszek P, Mikolajczak R, PP34 Gamma scintigraphy studies with 99mTc- amoxicillin sodium in bacterially infected and sterile inflamed rats, Derya Ilem-Ozdemir, Oya Caglayan-Orumlu, Makbule Asikoglu, PP35 Preparation of 99mTc- Amoxicillin Sodium Lyophilized Kit, Derya Ilem-Ozdemir, Oya Caglayan-Orumlu, Makbule Asikoglu, PP36 Outfits of Tracerlan FXC-PRO for 11C-Labeling, Arponen Eveliina, Helin Semi, Saarinen Timo, Vauhkala Simo, Kokkomäki Esa, Lehikoinen Pertti, PP37 Microfluidic synthesis of ω-[18F]fluoro-1-alkynes, Mariarosaria De Simone, Giancarlo Pascali, Ludovica Carzoli, Mauro Quaglierini, Mauro Telleschi, Piero A. Salvadori, PP38 Automated 18F-flumazenil production using chemically resistant disposable cassettes, Phoebe Lam, Martina Aistleitner, Reinhard Eichinger, Christoph Artner, PP39 The effect of the eluent solutions (TBAHCO3, Kryptand K2.2.2) on the radiochemical yields of 18F-Fluoromethylcholine, Surendra Nakka, Hemantha Kumara MC, Al-Qahtani Mohammed, PP40 [68Ga]Radiolabeling of short peptide that has a PET imaging potentials, Al-Qahtani, Mohammed, Al-Malki, Yousif, PP41 Is validation of radiochemical purity analysis in a public hospital in a developing country possible?, N Mambilima, SM Rubow, PP42 Improved automated radiosynthesis of [18F]FEPPA, N. Berroterán-Infante, M. Hacker, M. Mitterhauser, W. Wadsak, PP43 Synthesis and initial evaluation of Al18F-RESCA1-TATE for somatostatin receptor imaging with PET, Uta Funke, Frederik Cleeren, Joan Lecina, Rodrigo Gallardo, Alfons M. Verbruggen, Guy Bormans, PP44 Radiolabeling and SPECT/CT imaging of different polymer-decorated zein nanoparticles for oral administration, Rocío Ramos-Membrive, Ana Brotons, Gemma Quincoces, Laura Inchaurraga, Inés Luis de Redín, Verónica Morán, Berta García-García, Juan Manuel Irache, Iván Peñuelas, PP45 An analysis of the quality of 68Ga-DOTANOC radiolabelling over a 3 year period, Trabelsi, M., Cooper M.S., PP46 In vivo biodistribution of adult human mesenchymal stem cells I (MSCS-ah) labeled with 99MTC-HMPAO administered via intravenous and intra-articular in animal model. Preliminary results, Alejandra Abella, Teodomiro Fuente, Antonio Jesús Montellano, Teresa Martínez, Ruben Rabadan, Luis Meseguer-Olmo, PP47 Synthesis of [18F]F-exendin-4 with high specific activity, Lehtiniemi P, Yim C, Mikkola K, Nuutila P, Solin O, PP48 Experimental radionuclide therapy with 177Lu-labelled cyclic minigastrin and human dosimetry estimations, von Guggenberg E, Rangger C, Mair C, Balogh L, Pöstényi Z, Pawlak D, Mikołajczak R, PP49 Synthesis of radiopharmaceuticals for cell radiolabelling using anion exchange column, Socan A, Kolenc Peitl P, Krošelj M, Rangger C, Decristoforo C, PP50 [68Ga]peptide production on commercial synthesiser mAIO, Collet C., Remy S., Didier R,Vergote T.,Karcher G., Véran N., PP51 Dry kit formulation for efficient radiolabeling of 68Ga-PSMA, D. Pawlak, M. Maurin, P. Garnuszek, U. Karczmarczyk, R. Mikołajczak, PP52 Development of an experimental method using Cs-131 to evaluate radiobiological effects of internalized Auger-electron emitters, Pil Fredericia, Gregory Severin, Torsten Groesser, Ulli Köster, Mikael Jensen, PP53 Preclinical comparative evaluation of NOTA/NODAGA/DOTA CYCLO-RGD peptides labelled with Ga-68, R. Leonte, F. D. Puicea, A. Raicu, E. A. Min, R. Serban, G. Manda, D. Niculae, PP54 Synthesizer- and Kit-based preparation of prostate cancer imaging agent 68Ga-RM2, Marion Zerna, Hanno Schieferstein, Andre Müller, Mathias Berndt, PP55 Synthesis of pancreatic beta cell-specific [18F]fluoro-exendin-4 via strain-promoted aza-dibenzocyclooctyne/azide cycloaddition, Cheng-Bin Yim, Kirsi Mikkola, Pirjo Nuutila, Olof Solin, PP56 Automated systems for radiopharmacy, D. Seifert, J. Ráliš, O. Lebeda, PP57 Simple, suitable for everyday routine use quality control method to assess radionuclidic purity of cyclotron-produced 99mTc, Svetlana V. Selivanova, Helena Senta, Éric Lavallée, Lyne Caouette, Éric Turcotte, Roger Lecomte, PP58 Effective dose estimation using Monte Carlo simulation for patients undergoing radioiodine therapy, Marina Zdraveska Kochovska, Emilija Janjevik Ivanovska, Vesna Spasic Jokic, PP59 Chemical analysis of the rituximab radioimmunoconjugates in lyophilized formulations intended for oncological applications, Darinka Gjorgieva Ackova, Katarina Smilkov, Petre Makreski, Trajče Stafilov, Emilija Janevik-Ivanovska, PP61 The need and benefits of established radiopharmacy in developing African countries, Aschalew Alemu, Joel Munene Muchira, David Mwanza Wanjeh, Emilija Janevik-Ivanovska, PP62 University Master Program of Radiopharmacy – step forward for Good Radiopharmacy Education, Emilija Janevik-Ivanovska, Zoran Zdravev, Uday Bhonsle, Osso Júnior João Alberto, Adriano Duatti, Bistra Angelovska, Zdenka Stojanovska, Zorica Arsova Sarafinovska, Darko Bosnakovski, Darinka Gorgieva-Ackova, Katarina Smilkov, Elena Drakalska, Meera Venkatesh, Rubin Gulaboski, PP63 Synthesis and preclinical validations of a novel 18F-labelled RGD peptide prepared by ligation of a 2-cyanobenzothiazole with 1,2-aminothiol to image angiogenesis., Didier J. Colin, James A. H. Inkster, Stéphane Germain, Yann Seimbille

Published
2016

75. Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer

Author

Paquette, Michel, primary, Vilera-Perez, Luis-Guillermo, additional, Beaudoin, Simon, additional, Ekindi-Ndongo, Nadia, additional, Boudreaut, Pierre-Luc, additional, Bonin, Marc-Andre, additional, Battista, Marie-Claude, additional, Bentourkia, M'hamed, additional, Lopez, Angel F., additional, Lecomte, Roger, additional, Marsault, Eric, additional, Guérin, Brigitte, additional, Sabbagh, Robert, additional, and Leyton, Jeffrey V., additional

Published
2017
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77. Permafrost Comics: an education and outreach project

Author

Siewert, Matthias Benjamin, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Paquette, Michel, Hogström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, M., Sjöberg, Ylva, Rudy, A.C.A., Weege, Stefanie, Siewert, Matthias Benjamin, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Paquette, Michel, Hogström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, M., Sjöberg, Ylva, Rudy, A.C.A., and Weege, Stefanie

Abstract

Presentation of Permafrost Comics at the Polarforum. Polarforum is a meeting place for all those engaged in research concerning, or in, the polar regions, the Swedish mountain region and other Northern regions. The aim is to create transdisciplinary interfaces between researchers, the Swedish Polar Research Secretariat and other actors through work groups and networking. Government officials and others are welcome as observers. Polarforum currently has just over 300 members from some 40 Swedish seats of learning.

Published
2016

78. Permafrost Comics: Bridging the gap between science and society

Author

Rudy, Ashley, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Paquette, Michel, Hogström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, M., Siewert, Matthias Benjamin, Weege, Stefanie, Rudy, Ashley, Bouchard, Fréderic, Deshpande, Bethany, Fritz, Michael, Malenfant-Lepage, Julie, Paquette, Michel, Hogström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, M., Siewert, Matthias Benjamin, and Weege, Stefanie

Abstract

Here we present the first results of an entertaining and easily understandable scientific-based comic on the impacts of climate change in permafrost areas. Education and outreach is a fundamental component of scientific research activities. Especially for Arctic science, the involvement of local communities and the diffusion of scientific knowledge in schools is now an essential task on every researcher’s to-do list. The International Permafrost Association (IPA) Action Groups “A Frozen-Ground Cartoon” and “Permafrost and Culture” aim at filling the gap between indigenous knowledge, complex scientific results and outreach to the general public. It is possible to change global thinking, especially in relation to environmental friendly policy and industry, but only if awareness to the sensitive Arctic regions can be brought to the general public and to political decision makers. This can be hard to achieve, as scientific publications and knowledge are difficult to access for the general public. Permafrost comics explain the impact of climate change in permafrost areas, its effects on local communities, 172 ASM2016 Conference Program Oral Presentation and Poster Abstracts wildlife and changing landscape. We provide handouts with simple scientific background information that can be used by school teachers as educational material. The comics are part of a larger outreach and education project including posters and a short Frostbyte video. Everything will be freely available on the IPA website for download. For more information: https://www. researchgate.net/project/A-Frozen-Ground-CartoonExplaining-international-permafrost-research-usingcomic-strips http://ipa.arcticportal.org/activities/actiongroups

Published
2016

79. The future of permafrost research; contributions of early career researchers from the European Conference on Permafrost to ICARP III

Author

Sjöberg, Ylva, Bouchard, Fréderic, Cassidy, Alison, Deshpande, Bethany, Fritz, Michael, Högström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, Marc, Paquette, Michel, Rudy, Ashley, Siewert, Matthias, Weege, Stefanie, Sjöberg, Ylva, Bouchard, Fréderic, Cassidy, Alison, Deshpande, Bethany, Fritz, Michael, Högström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, Marc, Paquette, Michel, Rudy, Ashley, Siewert, Matthias, and Weege, Stefanie

Abstract

The Permafrost Young Researchers’ Workshop 2014, held during the latest European Conference on Permafrost in Évora, Portugal (June 2014) gathered 100 early career researchers from 20 countries to discuss and elaborate on the future of permafrost research. The event was a joint initiative of the two major early career researcher associations Permafrost Young Researchers Network (PYRN) and the Association of Polar Early career Scientists (APECS), as well as the regional research projects PAGE21 (EU) and ADAPT (Canada). Early career permafrost researchers worldwide were invited to submit important questions for permafrost research in the coming decade through an online survey. In total, 71 questions were submitted by 31 people from 15 countries, including males (54 %) and females (46 %), ranging from undergraduate students (19 %) to PhD students (35 %) and post docs (42 %). During the workshop, small groups of participants reviewed sets of submitted questions, grouped by topic, in an elaborate discussion exercise. The questions were evaluated using a series of predefined criteria to provide realistic and sound research questions. In each discussion group, questions were criticized, merged and re-written until each group produced a comprehensive question to submit to the rest of the participants. The participants then voted to elect questions that best represented the most important research avenues for permafrost research for the next decade. The top five questions that emerged from this process are: - How does permafrost degradation affect landscape dynamics at different spatio-temporal scales and which are the most important processes controlling these dynamics? - How can ground temperature models be improved to better represent factors affecting degradation, preservation, and aggradation of permafrost at high spatial resolutions? - In what ways can traditional knowledge be quantified and used in permafrost research? - What is the spatial distribution and the thaw su

Published
2015

80. Brief Communication: Future avenues for permafrost science from the perspective of early career researchers

Author

Fritz, Michael, Deshpande, Bethany, Bouchard, Fréderic, Högström, Elin, Malenfant-Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, Marc, Paquette, Michel, Rudy, Ashley, Siewert, Matthias, Sjöberg, Ylva, Weege, Stefanie, Fritz, Michael, Deshpande, Bethany, Bouchard, Fréderic, Högström, Elin, Malenfant-Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, Marc, Paquette, Michel, Rudy, Ashley, Siewert, Matthias, Sjöberg, Ylva, and Weege, Stefanie

Abstract

Accelerating climate change and increased economic and environmental interests in permafrost-affected regions have resulted in an acute need for more directed permafrost research. In June 2014, 88 early career researchers convened to identify future priorities for permafrost research. This multidisciplinary forum concluded that five research topics deserve greatest attention: permafrost landscape dynamics; permafrost thermal modelling; integration of traditional knowledge; spatial distribution of ground ice; and engineering issues. These topics underline the need for integrated research across a spectrum of permafrost-related domains and constitute a contribution to the Third International Conference on Arctic Research Planning (ICARP III).

Published
2015

84. The future of permafrost research: Contributions of early career researchers from the European Conference on Permafrost to ICARP III

Author

Paquette, Michel, Bouchard, Fréderic, Cassidy, Alison, Deshpande, Bethany, Fritz, Michael, Hogström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, Marc, Rudy, Ashley, Siewert, Matthias, Sjöberg, Ylva, Weege, Stefanie, Paquette, Michel, Bouchard, Fréderic, Cassidy, Alison, Deshpande, Bethany, Fritz, Michael, Hogström, Elin, Lepage, Julie, Morgenstern, Anne, Nieuwendam, Alexandre, Oliva, Marc, Rudy, Ashley, Siewert, Matthias, Sjöberg, Ylva, and Weege, Stefanie

Abstract

In June 2014, more than 75 Early Career Researchers (ECRs) attended the ECR Workshop 2014, a one-day event held prior to the 4th European Conference on Permafrost (EUCOP) in Évora, Portugal. One of the goals of this workshop was to elaborate future avenues of permafrost research from an ECR perspective during a forum with participants from various disciplines and countries. The outcome of this workshop is a “Permafrost Priority Sheet”, which will be presented to the International Permafrost Association (IPA) and will contribute to the establishment of research priorities leading up to into the 3rd International Conference on Arctic Research Planning (ICARP III) in 2015 in Toyama, Japan. This presentation will highlight some of the results that were obtained during the workshop, in a similar fashion as what will be presented at ICARP III. Additionally, it will focus on the organisation of the forum, the consultation process and the lessons learned from the overall experience. The results from this workshop took the form of research questions, from which five questions were elected by the participants as the most relevant at identifying gaps that need to be addressed in permafrost research. The broad range of topics include, engineering, remote sensing, traditional knowledge, massive ice, permafrost distribution, and more. Overall, these topics underscore the wide variety of specialties of the participants as well as the need for further research across a spectrum of permafrost-related topics. To date, this operation has been a success largely due to the extensive collaboration between the Association of Polar Early Career Scientists (APECS), Permafrost Young Researchers Network (PYRN), and the ECR organisations of inter-disciplinary projects Changing Permafrost in the Arctic and its Global Effects in the 21st Century (PAGE-21) and Arctic Development and Adaptation to Permafrost in Transition (ADAPT). This workshop was an ECR initiative from the beginning to the end a

Published
2014

85. Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [64Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists.

Author

Mansour, Nematallah, Dumulon ‐ Perreault, Véronique, Ait ‐ Mohand, Samia, Paquette, Michel, Lecomte, Roger, and Guérin, Brigitte

Subjects
PEPTIDE receptors, ENZYME inhibitors, CANCER cells, RADIOLABELING, POSITRON emission tomography
Abstract

In this study, we investigated for the first time the influence of 2-aminoethyl-piperazine-1-carboxylic acid (APCA) and amino-hexanedioic-1-acid (AHDA) on tumor uptake and elimination kinetics of [64Cu]-radiolabeled gastrin releasing peptide receptors (GRPR) antagonists. Three GRPR antagonists containing the RM26 sequence were synthesized and conjugated with NOTA via different linkers (LK): polyethylene glycol (PEG-neutral), APCA (dicationic) or AHDA (dianionic). The NOTA-LK-RM26 peptides were radiolabeled with 64Cu to assess their pharmacokinetic and positron emission tomography (PET) imaging properties using PC3 tumor-bearing athymic nude mice. The inhibition constants (Ki) of the 3 natCu/NOTA-LK-RM26 peptides bearing PEG, dicationic and dianionic linkers were 0.98 ± 0.48 nM, 0.95 ± 0.21 nM, and 17.97 ± 2.79 nM, respectively. The [64Cu] NOTA-LK-RM26 conjugates were prepared with labeling yields superior to 95% and specific activities of 67 to 77 TBq/mmol. The 3 radiopeptides were stable in vivo and showed GRPR-specific uptake in pancreas with a very fast washout of this tissue observed for [64Cu]-NOTA-AHDA-RM26 peptide. Results from imaging studies displayed specific PC3 tumor uptake for both [64Cu]-NOTA-APCA- and AHDA-RM26, similar kidney elimination and fast liver washout. Considering their adequate imaging characteristics, [64Cu]-NOTA-LK-RM26 bearing APCA- and AHDA-linkers are promising candidates for GRPR-targeted PET imaging prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2017
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89. Détection quantitative in vivo des récepteurs d'oestrogène par utilisation des traceurs 16a-[18F]fluoroestradiol et 4-fluoro-11b-méthoxy-16a-[18F] fluoroestradiol, et suivi d'hormonothérapie de tumeurs ER+ et ERaKD sur un modèle de souris par imagerie TEP

Author

Bénard, François, Paquette, Michel, Lecomte, Roger, Bénard, François, Paquette, Michel, and Lecomte, Roger

Abstract

À partir des adénocarcinomes mammaires de souris MC7-L1 et MC4-L2, deux lignées exprimant le récepteur d'oestrogène a(ERa), de nouvelles lignées dont l'expression d'ERa est réprimée ont été créées (ERaKD). Ainsi, l'introduction d'une séquence shRNA ciblant ERa: dans ces cellules par infection lentivirale a réduit d'environ 60% l'expression d'ERa; tel que confirmé par diverses techniques in vitro. D'abord, un protocole d'imagerie TEP quantitative au FES a été validé en utilisant un modèle de souris porteuses de tumeurs ER+/ ERaKD. En effet, une baisse notable (et similaire à la diminution d'expression d'ERa) du pourcentage de dose injectée par gramme (%ID/g) de FES a été observée dans les tumeurs ERaKD. De plus, les %ID/g obtenus ex vivo pour les tumeurs ER+ et ERaKD sont très similaires aux %ID/g obtenus par TEP au FES, supportant la validité de la méthode d'imagerie. Ensuite, ces tumeurs ont été suivies pendant 14 jours par imagerie TEP quantitative au [18F]-fluorodésoxyglucose (FDG) ou à la [11C]-méthionine ([11C]-MET) sous traitement avec différentes hormonothérapies, soient le tamoxifène, le letrozole et le fulvestrant. Les tumeurs ER+ ont capté moins de FDG et de [11C]-MET que les tumeurs ERaKD après 7 et 14 jours de traitement. Les groupes traités ont une captation moindre des 2 traceurs par rapport au groupe non-traité pour leurs tumeurs ER+ après 7 et 14 jours de thérapie au fulvestrant et au letrozole, tandis que les tumeurs ERaKD ne sont pas affectées. Quant au traitement au tamoxifène, aucune différence de captation n'est observée par rapport au groupe non-traité. Ainsi, le protocole utilisé n'est pas assez sensible et à trop court terme pour voir l'effet connu à plus long terme du tamoxifène sur la croissance de ces tumeurs ER+. Enfin, la captation et le contraste du 4FMFES ont été comparés au FES par imagerie TEP sur le même modèle de souris porteuses de tumeurs. La captation et le contraste se sont avérés supérieurs en utilisant le 4FMFES, comparés au

Published
2013

91. Relations entre la structure de la chromatine et la transcription dans les gènes ribosomaux pendant la réparation par excision de nucléotides (NER) dans différents mutants de délétion rad chez S. cerevisiae

Author

Bell, Brendan, Paquette, Michel, Hunting, Darel, Bell, Brendan, Paquette, Michel, and Hunting, Darel

Abstract

Des remaniements de la chromatine se produisent pendant la réparation de dimères de cyclobutane pyrimidine par la réparation par excision de nucléotide (NER). Par la suite, la structure de départ doit être rétablie pour conserver des fonctions génomiques normales. Le fonctionnement de la NER sur la chromatine non-nucléosomale et les mécanismes rétablissant la chromatine suite à la NER sont inconnus. L'analyse de la NER dans les gènes ribosomaux (ADNr), présents en plusieurs copies dont seulement une fraction est activement transcrite et nonnucléosomale, nous a permis de montrer que la réparation de CPD est rapide dans l'ADNr actif et que des réarrangements chromatiniens se produisent pendant la NER. De plus, la chromatine s'assemble sur l'ADNr nonnucléosomal durant les premiers événements de la NER, mais en absence de réparation. La reprise de la transcription suite à la réparation des CPD concide [i.e. coïncide] avec la réapparition de chromatine non-nucléosomale. Jusqu'à maintenant, seulement le passage de la machinerie de réplication était connu pour empaqueter de novo les ADNr dans des nucléosomes. Ainsi, peu après la formation de dommages UV sur l'ADN, il y a assemblage de chromatine. Aussi, la protéine Rad4, quoique essentielle à la NER, n'est pas encore bien caractérisée; sa fonction exacte n'est pas encore identifiée. Ainsi, il est connu que la délétion de celle-ci entraîne une forte sensibilité aux UV et une incapacité de réparer des dimères dans les gènes ARN polymérase II et les régions non transcrites du génome. Or, malgré l'absence de réparation du brin non transcrit des gènes ribosomaux (ARN pol. I), le brin transcrit est quant à lui réparé à 50-60%. Dans le but de mieux caractériser Rad4, nous avons étudié plus en détail la réparation NER des gènes ribosomaux en séparant la fraction active non nucléosomale de la fraction inactive nucléosomale. La réparation est normale dans le brin transcrit de la fraction active, alors que le brin non transcrit de la

Published
2006

95. Algorithms for optimal outlier removal

Author

Atanassov, Rossen, primary, Bose, Prosenjit, additional, Couture, Mathieu, additional, Maheshwari, Anil, additional, Morin, Pat, additional, Paquette, Michel, additional, Smid, Michiel, additional, and Wuhrer, Stefanie, additional

Published
2009
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99. Communication in Networks with Random Dependent Faults.

Author

Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Pandu Rangan, C., Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Kučera, Luděk, Kučera, Antonín, Kranakis, Evangelos, Paquette, Michel, and Pelc, Andrzej

Abstract

The aim of this paper is to study communication in networks where nodes fail in a random dependent way. In order to capture fault dependencies, we introduce the neighborhood fault model, where damaging events, called spots, occur randomly and independently with probability p at nodes of a network, and cause faults in the given node and all of its neighbors. Faults at distance at most 2 become dependent in this model and are positively correlated. We investigate the impact of spot probability on feasibility and time of communication in the fault-free part of the network. We show a network which supports fast communication with high probability, if p ≤ 1/clogn. We also show that communication is not feasible with high probability in most classes of networks, for constant spot probabilities. For smaller spot probabilities, high probability communication is supported even by bounded degree networks. It is shown that the torus supports communication with high probability when p decreases faster than 1/n1/2, and does not when p ∈ 1/O(n1/2). Furthermore, a network built of tori is designed, with the same fault-tolerance properties and additionally supporting fast communication. We show, however, that networks of degree bounded by a constant d do not support communication with high probability, if p ∈ 1/O(n1/d). While communication in networks with independent faults was widely studied, this is the first analytic paper which investigates network communication for random dependent faults. [ABSTRACT FROM AUTHOR]

Published
2007
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