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51. A Single Arm, Phase II Study of Eltrombopag to Enhance Platelet Count Recovery in Older Patients with Acute Myeloid Leukemia (AML) Undergoing Remission Induction Therapy

Author

Mukherjee, Sudipto, primary, Li, Hong, additional, Hobbs, Brian P., additional, Gerds, Aaron T., additional, Advani, Anjali S., additional, Carraway, Hetty E., additional, Nazha, Aziz, additional, Bogati, Samjhana, additional, Parsons, Eric, additional, Pannell, Benjamin, additional, Kalaycio, Matt, additional, Saunthararajah, Yogenthiran, additional, Maciejewski, Jaroslaw P., additional, and Sekeres, Mikkael A., additional

Published
2019
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62. Network-based mobility management in the evolved 3GPP core network

Author

Ali, Irfan, Casati, Alessio, Chowdhury, Kuntal, Nishida, Katsutoshi, Parsons, Eric, Schmid, Stefan, and Vaidya, Rahul

Subjects
Quality of service, Wireless technology, Company business management, Mobile communication systems -- Research, Wireless communication systems -- Research
Published
2009

63. A Phase 1 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib (MLN9708) for Relapsed/ Refractory Acute Myeloid Leukemia (AML)

Author

Advani, Anjali S., primary, Cooper, Brenda, additional, Elson, Paul, additional, Mukherjee, Sudipto, additional, Fensterl, Jaime, additional, Gerds, Aaron T., additional, Caimi, Paolo F., additional, Tomlinson, Ben K., additional, Malek, Ehsan, additional, Little, Jane A., additional, Rush, Mary Lynn, additional, Bogati, Samjhana, additional, Parsons, Eric, additional, Kane, Donna, additional, Carraway, Hetty E., additional, Nazha, Aziz, additional, Hamilton, Betty K., additional, Sobecks, Ronald, additional, Bevier, Barbara, additional, Goebel, Christopher, additional, Zimmerman, Cassie, additional, Nielsen, Alek d, additional, Hirsch, Cassandra M., additional, Maciejewski, Jaroslaw P., additional, Kalaycio, Matt, additional, deLima, Marcos, additional, Jacobberger, James, additional, Woost, Philip, additional, and Sekeres, Mikkael A., additional

Published
2016
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65. A Phase 1 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib (MLN9708) for Relapsed/ Refractory Acute Myeloid Leukemia (AML): Final Results

Author

Advani, Anjali S., Cooper, Brenda W., Visconte, Valeria, Elson, Paul, Chan, E. Ricky, Carew, Jennifer, Mukherjee, Sudipto, Gerds, Aaron T., Carraway, Hetty E., Nazha, Aziz, Hamilton, Betty K., Sobecks, Ronald, Caimi, Paolo, Tomlinson, Benjamin, Malek, Ehsan, Little, Jane A., Fensterl, Jaime, Unger, Allison, Zimmerman, Cassie, Goebel, Christopher, Hoxha, Nita, Siebenaller, Caitlin, Thomas, Jenna, Rush, Mary Lynn, Bogati, Samjhana, Parsons, Eric, Diligente, Rachael, Kane, Donna, Nielsen, Alek, Hirsch, Cassandra M., Edelheit, Simone, Miron, Alexander, Pink, John, Maciejewski, Jaroslaw P., Kalaycio, Matt, De Lima, Marcos, and Sekeres, Mikkael A.

Published
2017
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70. Investigation and Characterization of a Cycloidal Rotor for Application to a Micro-Air Vehicle

Author

Parsons, Eric Shawn and Parsons, Eric Shawn

Abstract

In recent years, interest has been growing in a new class of very small flight vehicles called micro air vehicles (MAVs). The use of cycloidal propulsion for such a vehicle has some advantages over other configurations that make it an attractive alternative to fixed-wing and rotary-wing vehicles. In a cycloidal blade system, a series of blades rotate around an axis of rotation oriented parallel to both the blades and the horizon. As the blades rotate about the axis, their pitch angle is varied periodically. This paper investigates a small scale cycloidal rotor to determine its viability for use on a micro air vehicle. An analytical model, using a combination of wind turbine theory and an indicial solution for the aerodynamic response was developed in an attempt to predict rotor performance. A small experimental rotor was constructed and tested to determine the effects of blade number, blade pitch angle, and rotational speed on thrust output, power requirements, and efficiency. While a six-bladed configuration demonstrated more thrust production than a three-bladed one, results showed lower efficiency than that predicted and may suffer from blade-wake interference. High blade pitch angles of $30^{\circ}$ to $40^{\circ}$ are necessary to meet thrust requirements for an MAV. Experimental results are compared with predictions as well as to results from a conventional rotor to ascertain the effectiveness of the cycloidal configuration. A maximum figure of merit of approximately 0.55 is achieved during testing, comparable with the conventional rotor. However, figure of merit for the cycloidal rotor declines as rotational speed increases, severely limiting its usefulness if high efficiency is necessary. An investigation of the flow field around the rotor is conducted to achieve an acceptable quantitative picture of the rotor downwash. Results demonstrate that outflow is directed approximately $15^{\circ}$ from the vertical. Although it appears that flow may expand upon exi

Published
2005

79. The Sensitivity of Value-Added Estimates to Specification Adjustments: Evidence From School-and Teacher-Level Models in Missouri.

Author

Ehlert, Mark, Koedel, Cory, Parsons, Eric, and Podgursky, Michael J.

Subjects
VALUE-added assessment (Education), EDUCATIONAL accountability, TEACHER evaluation, TEACHER effectiveness, ESTIMATION theory
Abstract

We provide a side-by-side comparison of school and teacher growth measures estimated from different value-added models (VAMs). We compare VAMs that differ in terms of which student and school-level (or teacher-level) control variables are included and how these controls are included. Our richest specification includes 3 years of prior test scores for students and the standard demographic controls; our sparsest specification conditions only on a single prior test score. For both schools and teachers, the correlations between VAM estimates across the different models are high by conventional standards (typically at or above 0.90). However, despite the high correlations overall, we show that the choice of which controls to include in VAMs, and how to include them, meaningfully influences school and teacher rankings based on model output. Models that are less aggressive in controlling for student-background and schooling-environment information systematically assign higher rankings to more-advantaged schools, and to individuals who teach at these schools. [ABSTRACT FROM AUTHOR]

Published
2014
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84. The Design, Synthesis, and Biological Activity of Novel Conformationally Restricted Small Molecule Antibiotics Targeting the T-box Riboswitch

Author

Parsons, Eric S.

Subjects
Biochemistry, Organic Chemistry, Chemistry, Biology, T-box riboswitch, antiterminator, small molecule, antibiotic, docking, Gram-positive bacteria, drug discovery
Abstract

The T-box riboswitch is an attractive RNA drug target found in gram-positive bacteria. The work described herein details the design, synthesis, and bioactivity of novel conformationally restricted small molecules that were developed in an effort to target the antiterminator structure of the T-box riboswitch. Compounds were designed by use of in silico docking studies. Select compounds were then synthesized as racemates and their bioactivity against the T-box antiterminator was tested, which allowed for the identification of potential lead compounds that were synthesized as pure enantiomers. A fluorescence monitored in vitro transcription assay performed on these enantiopure triazole analogs revealed enantioselective binding interactions with the T-box riboswitch antiterminator, as well as statistically significant inhibition of tRNA-induced transcriptional readthrough.

Published
2022

87. Internal Image Motion Compensation System for the Shuttle Infrared Telescope Facility

Author

Lorell, Kenneth R., Parsons, Eric K., and David, J.

Abstract

The Shuttle Infrared Telescope Facility (SIRTF) is being designed as a 1-m, cryogenically cooled telescope capable of a thirty-fold improvement over currently available infrared instruments. The SIRTF, mounted in the Orbiter bay on the Instrument Pointing System (IPS), requires that the image at the focal plane be stabilized to better than 0.1 arcsec with an absolute accuracy of 1 arcsec in order to attain this goal. Current estimates of IPS performance for both stability and accuracy indicate that additional stabilization will be necessary to meet the SIRTF requirements. An Image Motion Compensation (IMC) system, utilizing a Charge Coupled Device (CCD) star tracker located at the focal plane and a steerable mirror in the SIRTF optical path, has been designed to work in conjunction with the IPS. The CCD tracks multiple stars simultaneously and through the use of a high-performance microcomputer generates three-axis attitude errors and gyro drift estimates to correct the IPS gyros. A high-bandwidth feed-forward loop, driven directly from the IPS gyro package, controls the steering mirror in order to correct disturbances not compensated for by the IPS control system. The SIRTF IMC system is described in detail and performance is analyzed with respect to system noise inputs, environmental disturbances, and error sources such as bending and feed-forward scale factor. It is concluded that the SIRTF accuracy and stability requirements can be met with this design.

Published
1979
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91. A new technique for establishing and maintaining an anteromedial knee portal.

Author

Parsons EM and Bono JV

Subjects
Humans, Knee Joint pathology, Treatment Outcome, Arthroscopy methods, Knee, Knee Joint surgery, Pain, Postoperative etiology
Abstract

Precise placement of the anteromedial portal is critical to the safety and efficacy of knee arthroscopy. Our described technique establishes and maintains a properly placed portal with minimal capsular violation using a needle arthrotomy and the outer shaver barrel as a cannula. This technique has the dual benefit of optimizing instrument access to the knee without large portal arthrotomies and reducing postoperative pain and swelling by minimizing fluid extravasation.

Published
2008

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