51. Effect of increased intra-abdominal pressure on liver histology and hemodynamics: An experimental study
- Author
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Antoniou, E.A. Kairi, E. Margonis, G.A. Andreatos, N. Sasaki, K. Damaskos, C. Garmpis, N. Samaha, M. Argyra, E. Polymeneas, G. Weiss, M.J. Pawlik, T.M. Voros, D. Kouraklis, G.
- Abstract
Background: While reduction of portal venous (PV) blood flow has been described in animal models of intra-abdominal hypertension, reports on compensatory changes in hepatic arterial (HA) flow, known as the hepatic arterial buffer response are controversial. Materials and Methods: Pneumoperitoneum with helium was induced in 13 piglets. Hemodynamic measurements and pathological assessment were conducted at baseline and during the three subsequent phases: Phase A: 45 minutes with a stable intraabdominal pressure of 25 mmHg; phase B: 45 minutes with a stable intra-abdominal pressure of 40 mmHg; and phase C during which the abdomen was re-explored and reperfusion of the liver was allowed to take place. Results: Phase B pressure was significantly greater than phase A pressure in both the PV and the inferior vena cava, demonstrating a positive association between escalating intra-abdominal hypertension and the pressure in these two vessels (all p
- Published
- 2018