51. Immunoexpression of Macroh2a in Uveal Melanoma.
- Author
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Salvatorelli, Lucia, Puzzo, Lidia, Bartoloni, Giovanni, Palmucci, Stefano, Longo, Antonio, Russo, Andrea, Reibaldi, Michele, Vinciguerra, Manlio, Li Volti, Giovanni, and Caltabiano, Rosario
- Subjects
MELANOMA ,UVEA ,LIVER metastasis ,EARLY diagnosis - Abstract
MacroH2A is a histone variant whose expression has been studied in several neoplasms, including cutaneous melanomas (CMs). In the literature, it has been demonstrated that macroH2A.1 levels gradually decrease during CM progression, and a high expression of macroH2A.1 in CM cells relates to a better prognosis. Although both uveal and cutaneous melanomas arise from melanocytes, uveal melanoma (UM) is biologically and genetically distinct from the more common cutaneous melanoma. Metastasis to the liver is a frequent occurrence in UM, and about 40%–50% of patients die of metastatic disease, even with early diagnosis, proper treatment, and close follow-up. We wanted to investigate macroH2A.1 immunohistochemical expression in UM. Our results demonstrated that mH2A.1 expression was higher in metastatic UM (21/23, 91.4%), while only 18/32 (56.3%). UMs without metastases showed mH2A.1 staining. These data could suggest a possible prognostic role for mH2A.1 and could form a basis for developing new pharmacological strategies for UM treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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