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53. Trans fatty acid biomarkers and incident type 2 diabetes: pooled analysis of 12 prospective cohort studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

Author

Lai, Heidi T.M., Imamura, Fumiaki, Korat, Andres V. Ardisson, Murphy, Rachel A., Tintle, Nathan, Bassett, Julie K., Chen, Jiaying, Kröger, Janine, Chien, Kuo-Liong, Senn, Mackenzie, Wood, Alexis C., Forouhi, Nita G., Schulze, Matthias B., Harris, William S., Vasan, Ramachandran S., Hu, Frank, Giles, Graham G., Hodge, Allison, Djousse, Luc, Brouwer, Ingeborg A., Qian, Frank, Sun, Qi, Wu, Jason H.Y., Marklund, Matti, Lemaitre, Rozenn N., Siscovick, David S., Fretts, Amanda M., Shadyab, Aladdin H., Manson, JoAnn E., Howard, Barbara V., Robinson, Jennifer G., Wallace, Robert B., Wareham, Nick J., Chen, Yii-Der Ida, Rotter, Jerome I., Tsai, Michael Y., Micha, Renata, Mozaffarian, Dariush, Health Sciences, APH - Health Behaviors & Chronic Diseases, and APH - Mental Health

Subjects
Adult, Advanced and Specialized Nursing, Adolescent, Endocrinology, Diabetes and Metabolism, Fatty Acids, Trans Fatty Acids, Fatty Acids and Outcomes Research Consortium (FORCE), Cohort Studies, Endocrinology & Metabolism, Diabetes Mellitus, Type 2, SDG 3 - Good Health and Well-being, Risk Factors, Outcome Assessment, Health Care, Internal Medicine, Humans, Prospective Studies, Epidemiology/Health Services Research, Biomarkers, 11 Medical and Health Sciences
Abstract

OBJECTIVE Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged ≥18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics. RESULTS During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94–1.25); cis/trans-18:2, 0.89 (0.73–1.07); and trans/cis-18:2, 0.87 (0.73–1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67–0.99], 0.86 [0.75–0.99], and 0.84 [0.74–0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P ≥ 0.1). CONCLUSIONS Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.

Published
2022

54. Additional file 1 of Triglyceride-glucose index variability and incident cardiovascular disease: a prospective cohort study

Author

Li, Haibin, Zuo, Yingting, Qian, Frank, Chen, Shuohua, Tian, Xue, Wang, Penglian, Li, Xia, Guo, Xiuhua, Wu, Shouling, and Wang, Anxin

Abstract

Additional file 1: Figure S1. Study design. Figure S2. Distribution of TyG variability. Figure S3. Distribution of slope of TyG index. Figure S4. Restricted cubic spline regression for the association of baseline, mean, and variability of triglyceride-glucose index with risk of cardiovascular disease. Figure S5. Forest plot of adjusted hazard ratio for cardiovascular disease by TyG index variability categories. Figure S6. Forest plot of adjusted hazard ratio for cardiovascular disease by TyG variability according to RMSE (root-mean-square error), SD (standard deviation), CV (coefficient of variation), and VIM (independent of the mean). Figure S7. E-value for cardiovascular disease according to baseline, mean, and variability of TyG index. Table S1. Association between slope of TyG index and the incidence of cardiovascular disease. Table S2. Sensitivity analysis for the association between tertiles of baseline, mean, and variability of TyG index and the incidence of cardiovascular disease.

Published
2022
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55. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Author

Qian, Frank, Ardisson Korat, Andres V, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K, Zhou, Xia, Bassett, Julie K, Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C, Lankinen, Maria, Murphy, Rachel A, Samieri, Cecilia, Pertiwi, Kamalita, De Mello, Vanessa D, Guan, Weihua, Forouhi, Nita G, Wareham, Nick, Hu, InterAct Consortium Frank B, Riserus, Ulf, Lind, Lars, Harris, William S, Shadyab, Aladdin H, Robinson, Jennifer G, Steffen, Lyn M, Hodge, Allison, Giles, Graham G, Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindström, Jaana, Laakso, Markku, Siscovick, David S, Helmer, Catherine, Geleijnse, Johanna M, Wu, Jason HY, Fretts, Amanda, Lemaitre, Rozenn N, Micha, Renata, Mozaffarian, Dariush, Sun, Qi, Fatty Acids And Outcomes Research Consortium (FORCE), Qian, Frank [0000-0002-5579-3410], Virtanen, Jyrki K [0000-0002-0648-999X], Hirakawa, Yoichiro [0000-0002-4405-4399], Pertiwi, Kamalita [0000-0003-2861-9051], de Mello, Vanessa D [0000-0003-3414-6983], Forouhi, Nita G [0000-0002-5041-248X], Ninomiya, Toshiharu [0000-0003-1345-9032], Laakso, Markku [0000-0002-3394-7749], Lemaitre, Rozenn N [0000-0002-7038-1844], Sun, Qi [0000-0002-8480-1563], and Apollo - University of Cambridge Repository

Subjects
Cohort Studies, Diabetes Mellitus, Type 2, Docosahexaenoic Acids, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Humans, Prospective Studies, Biomarkers
Abstract

OBJECTIVE: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS: A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS: Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.

Published
2021

56. Dietary phytoestrogens and total and cause-specific mortality: results from 2 prospective cohort studies.

Author

Zhangling Chen, Qian, Frank, Yang Hu, Voortman, Trudy, Yanping Li, Rimm, Eric B., and Qi Sun

Subjects
CAUSES of death, LIGNANS, CONFIDENCE intervals, PUBLIC health, ISOFLAVONES, DESCRIPTIVE statistics, QUESTIONNAIRES, RESEARCH funding, DEATH, PHYTOESTROGENS
Abstract

Background: Evidence regarding dietary phytoestrogens in relation to mortality remains limited. Objectives: The objective of the study is to examine the associations of intake of isoflavones, lignans, and coumarins with total and cause-specific mortality in US males and females. Methods: We followed 75,981 females in the Nurses' Health Study (1984-2018) and 44,001 males in the Health Professionals Follow-up Study (1986-2018), who were free of cardiovascular disease (CVD), diabetes, or cancer at baseline. Their diet was repeatedly assessed using validated food frequency questionnaires every 2-4 y. Associations with mortality were assessed using time-dependent Cox models with adjustments for demographics, dietary and lifestyle factors, and medical history. Results: During 3,427,156 person-years of follow-up, we documented 50,734 deaths, including 12,492 CVD deaths, 13,726 cancer deaths, and 24,516 other non-CVD and noncancer deaths. After multivariable adjustment, the higher total phytoestrogen intake was associated with lower risk of total CVD and other non-CVD and noncancer mortality: comparing extreme quintiles, the pooled HRs (95% CIs) were 0.89 (0.87, 0.92), 0.90 (0.85, 0.96), and 0.86 (0.82, 0.90), respectively. We did not find a significant association with cancer mortality [0.97 (0.92, 1.03)]. For individual phytoestrogens in relation to total mortality, the pooled HRs (95% CIs) comparing extreme quintiles were 0.90 (0.87, 0.92) for isoflavones, 0.93 (0.90, 0.96) for lignans, and 0.93 (0.90, 0.95) for coumarins. Individual phytoestrogens were also significantly associated with lower risk of CVD mortality and other types of mortality. Primary food sources of phytoestrogens, including tofu, soy milk, whole grains, tea, and flaxseed, were also inversely associated with total mortality. Conclusions: A higher intake of total phytoestrogens, including isoflavones, lignans, and coumarins, and foods rich in these compounds was associated with lower risk of total and certain cause-specific mortality in generally healthy US adults. These data suggest that these phytochemicals and their dietary sources may be integrated into an overall healthy diet to achieve a longer life span. [ABSTRACT FROM AUTHOR]

Published
2023
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58. Abstract P212: Circulating And Tissue Omega-3 Fatty Acid Biomarkers And Incident Atrial Fibrillation: An Individual Participant-level Pooled Analysis Of Prospective Studies

Author

Qian, Frank, primary, Tintle, Nathan, additional, Lemaitre, Rozenn, additional, Imamura, Fumiaki, additional, Nomura, Sarah, additional, Guan, Weihua, additional, Kim, Eunjung, additional, Virtanen, Jyrki K, additional, Bork, Christian, additional, Hirakawa, Yoichiro, additional, O'Donoghue, Michelle, additional, Sala-Vila, Aleix, additional, Ardisson Korat, Andres V, additional, Sun, Qi, additional, Rimm, Eric B, additional, Forouhi, Nita G, additional, Tsai, Michael Y, additional, Pester, Julie, additional, Albert, Christine M, additional, Ninomiya, Toshiharu, additional, Bayés-Genís, Antoni, additional, Wu, Jason H, additional, Mozaffarian, Dariush, additional, Harris, William S, additional, and Siscovick, David S, additional

Published
2022
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59. Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

Author

Lai, Heidi TM., primary, Imamura, Fumiaki, primary, Korat, Andres V. Ardisson, primary, Murphy, Rachel A., primary, Tintle, Nathan, primary, Bassett, Julie K., primary, Chen, Jiaying, primary, Kröger, Janine, primary, Chien, Kuo-Liong, primary, Senn, Mackenzie, primary, Wood, Alexis C., primary, Forouhi, Nita G., primary, Schulze, Matthias B., primary, Harris, William S., primary, Vasan, Ramachandran S., primary, Hu, Frank, primary, Giles, Graham G., primary, Hodge, Allison, primary, Djousse, Luc, primary, Brouwer, Ingeborg A., primary, Qian, Frank, primary, Sun, Qi, primary, Wu, Jason HY., primary, Marklund, Matti, primary, Lemaitre, Rozenn N., primary, Siscovick, David S., primary, Fretts, Amanda M., primary, Shadyab, Aladdin H., primary, Manson, JoAnn E., primary, Howard, Barbara V., primary, Robinson, Jennifer G., primary, Wallace, Robert B., primary, Wareham, Nick J., primary, Chen, Yii-Der Ida, primary, Rotter, Jerome I., primary, Tsai, Michael Y., primary, Micha, Renata, primary, Mozaffarian, Dariush, primary, and (FORCE), the Fatty Acids and Outcomes Research Consortium, primary

Published
2022
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60. Prepregnancy plant-based diets and the risk of gestational diabetes mellitus: a prospective cohort study of 14,926 women

Author

Chen, Zhangling, primary, Qian, Frank, additional, Liu, Gang, additional, Li, Mengying, additional, Voortman, Trudy, additional, Tobias, Deirdre K, additional, Ley, Sylvia H, additional, Bhupathiraju, Shilpa N, additional, Li, Ling-Jun, additional, Chavarro, Jorge E, additional, Sun, Qi, additional, Hu, Frank B, additional, and Zhang, Cuilin, additional

Published
2021
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61. Abstract 11848: Biomarkers of Glucose-Insulin Homeostasis, Randomized Treatment With Omega-3 and Vitamin D Supplementation, and Incident Type 2 Diabetes: Prospective Analysis From the Vitamin D and Omega-3 Trial (VITAL)

Author

Qian, Frank, primary, Guo, Yanjun, additional, Gibson, Heike, additional, Gomelskaya, Natalya, additional, Liu, Yanyan, additional, Demler, Olga, additional, Cook, Nancy R, additional, Lee, I-min M, additional, Buring, Julie E, additional, Larsen, Julia A, additional, Boring, Jennifer, additional, Mcphaul, Michael J, additional, Manson, Joann E, additional, Pradhan, Aruna D, additional, and Mora, Samia, additional

Published
2021
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62. Abstract 12860: Effects of Marine Omega-3 and Vitamin D Supplementation on Circulating Biomarkers of Glucose-Insulin Homeostasis and Incident Cardiovascular Disease in the Vitamin D and Omega-3 Trial (VITAL)

Author

Qian, Frank, primary, Guo, Yanjun, additional, Gibson, Heike, additional, Gomelskaya, Natalya, additional, Liu, Yanyan, additional, Demler, Olga, additional, Cook, Nancy R, additional, Lee, I-min M, additional, Buring, Julie E, additional, Larsen, Julia A, additional, Boring, Jennifer, additional, Mcphaul, Michael J, additional, Manson, Joann E, additional, Pradhan, Aruna D, additional, and Mora, Samia, additional

Published
2021
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64. Association of Habitual Alcohol Consumption With Long-term Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes

Author

Hinkle, Stefanie N., primary, Bao, Wei, additional, Wu, Jing, additional, Sun, Yangbo, additional, Ley, Sylvia H., additional, Tobias, Deirdre K., additional, Qian, Frank, additional, Rawal, Shristi, additional, Zhu, Yeyi, additional, Chavarro, Jorge E., additional, Hu, Frank B., additional, and Zhang, Cuilin, additional

Published
2021
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66. Diabetes Care

Author

QIAN, Frank, ARDISSON KORAT, Andres V., IMAMURA, Fumiaki, MARKLUND, Matti, TINTLE, Nathan, VIRTANEN, Jyrki K., ZHOU, Xia, BASSETT, Julie K., LAI, Heidi, HIRAKAWA, Yoichiro, CHIEN, Kuo-Liong, WOOD, Alexis C., LANKINEN, Maria, MURPHY, Rachel A., SAMIERI, Cecilia, PERTIWI, Kamalita, DE MELLO, Vanessa D., GUAN, Weihua, FOROUHI, Nita G., WAREHAM, Nick, HU, InterAct Consortium Frank B, RISERUS, Ulf, LIND, Lars, HARRIS, William S., SHADYAB, Aladdin H., ROBINSON, Jennifer G., STEFFEN, Lyn M., HODGE, Allison, GILES, Graham G., NINOMIYA, Toshiharu, UUSITUPA, Matti, TUOMILEHTO, Jaakko, LINDSTROM, Jaana, LAAKSO, Markku, SISCOVICK, David S., HELMER, Catherine, GELEIJNSE, Johanna M., WU, Jason H. Y., FRETTS, Amanda, LEMAITRE, Rozenn N., MICHA, Renata, MOZAFFARIAN, Dariush, SUN, Qi, FATTY, Acids, and OUTCOMES RESEARCH, Consortium

Published
2021

67. Modifiable risk factors and long term risk of type 2 diabetes among individuals with a history of gestational diabetes mellitus: prospective cohort study.

Author

Jiaxi Yang, Qian, Frank, Chavarro, Jorge E., Ley, Sylvia H., Tobias, Deirdre K., Yeung, Edwina, Hinkle, Stefanie N., Wei Bao, Mengying Li, Aiyi Liu, Mills, James L., Qi Sun, Willett, Walter C., Hu, Frank B., and Cuilin Zhang

Subjects
OBESITY, LIFESTYLES, CONFIDENCE intervals, SELF-evaluation, TYPE 2 diabetes, RISK assessment, REPEATED measures design, EXERCISE, EXERCISE intensity, ALCOHOL drinking, HEALTH behavior, GESTATIONAL diabetes, WOMEN'S health, LONGITUDINAL method, DOSE-response relationship in biochemistry, DISEASE risk factors
Published
2022
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68. The authors reply

Author

Wu, Yi-Luen, primary, Hsu, Wan-Ting, additional, Qian, Frank, additional, and Lee, Chien-Chang, additional

Published
2021
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69. Abstract 026: Biomarkers Of Dairy Fat Intake Associated With Lower Cardiovascular Disease Risk: A Cohort Study And Meta-analysis

Author

Trieu, Kathy, primary, Bhat, Saiuj, additional, Dai, Zhaoli, additional, Leander, Karin, additional, Gigante, Bruna, additional, Qian, Frank, additional, Ardisson Korat, Andres, additional, Sun, Qi, additional, Pan, Xiongfei, additional, Laguzzi, Federica, additional, Cederholm, Tommy, additional, De Faire, Ulf, additional, Hellenius, Mai-Lis, additional, Wu, Jason H, additional, Risérus, Ulf, additional, and Marklund, Matti, additional

Published
2021
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72. Optimal initial antibiotic regimen for the treatment of acute appendicitis: a systematic review and network meta-analysis with surgical intervention as the common comparator

Author

Wang, Chih-Hung, primary, Yang, Chi-Chun, additional, Hsu, Wan-Ting, additional, Qian, Frank, additional, Ding, Julia, additional, Wu, Han-Ping, additional, Tsai, Jih-Jin, additional, Yang, Chia-Jui, additional, Su, Ming Yang, additional, Chen, Shyr-Chyr, additional, and Lee, Chien-Chang, additional

Published
2021
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73. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Author

Qian, Frank, primary, Korat, Andres V Ardisson, primary, Imamura, Fumiaki, primary, Marklund, Matti, primary, Tintle, Nathan, primary, Virtanen, Jyrki K, primary, Zhou, Xia, primary, Bassett, Julie K, primary, Lai, Heidi, primary, Hirakawa, Yoichiro, primary, Chien, Kuo-Liong, primary, Wood, Alexis C, primary, Lankinen, Maria, primary, Murphy, Rachel A, primary, Samieri, Cecilia, primary, Pertiwi, Kamalita, primary, Mello, Vanessa D de, primary, Guan, Weihua, primary, Forouhi, Nita G, primary, Wareham, Nick, primary, Consortium, InterAct, primary, Hu, Frank B, primary, Riserus, Ulf, primary, Lind, Lars, primary, Harris, William S, primary, Shadyab, Aladdin H, primary, Robinson, Jennifer G, primary, Steffen, Lyn M, primary, Hodge, Allison, primary, Giles, Graham G, primary, Ninomiya, Toshiharu, primary, Uusitupa, Matti, primary, Tuomilehto, Jaakko, primary, Lindström, Jaana, primary, Laakso, Markku, primary, Siscovick, David S, primary, Helmer, Catherine, primary, Geleijnse, Johanna M, primary, Wu, Jason HY, primary, Fretts, Amanda, primary, Lemaitre, Rozenn N, primary, Micha, Renata, primary, Mozaffarian, Dariush, primary, Sun, Qi, primary, and (FORCE), the Fatty Acids and Outcomes Research Consortium, primary

Published
2021
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80. 1373-P: Adherence to Healthy Lifestyle on Subsequent Risk of Type 2 Diabetes (T2D) among Women with a History of Gestational Diabetes Mellitus (GDM): A Prospective Cohort Study

Author

QIAN, FRANK, primary, CHAVARRO, JORGE E., additional, LEY, SYLVIA H., additional, TOBIAS, DEIRDRE, additional, YEUNG, EDWINA, additional, LI, MENGYING, additional, LIU, AIYI, additional, MILLS, JAMES, additional, SUN, QI, additional, HU, FRANK, additional, and ZHANG, CUILIN, additional

Published
2020
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81. Abstract P414: Biomarkers of Very Long-chain Saturated Fatty Acids and Incident Coronary Heart Disease: Prospective Evidence From 15 Cohorts in the Fatty Acids and Outcomes Research Consortium

Author

Ardisson Korat, Andres V, primary, Qian, Frank, additional, Imamura, Fumiaki, additional, Tintle, Nathan, additional, Chen, Jiaying, additional, Van Dam, Rob M, additional, Virtanen, Jyrki K, additional, Bassett, Julie K, additional, Bartz, Traci M, additional, Hirakawa, Yoichiro, additional, Chien, Kuo-Liong, additional, Frazier-Wood, Alexis, additional, Murphy, Rachel A, additional, Samieri, Cecilia, additional, Sun, Qi, additional, Hu, Frank, additional, Wu, Jason H, additional, Micha, Renata, additional, Mozaffarian, Dariush, additional, and Lemaitre, Rozenn, additional

Published
2020
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82. Abstract P384: Healthy Lifestyle Factors and Cardiovascular Disease Risk in a Prospective Cohort of Women With a History of Gestational Diabetes Mellitus

Author

Qian, Frank, primary, Tobias, Deirdre K, additional, Ley, Sylvia H, additional, Chavarro, Jorge, additional, Liu, Gang, additional, Hinkle, Stefanie N, additional, Yeung, Edwina, additional, Mills, James L, additional, Liu, Aiyi, additional, Sun, Qi, additional, Hu, Frank, additional, and Zhang, Cuilin, additional

Published
2020
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94. Serum Cholesterol Levels within the High Normal Range are Associated with Better Cognitive Performance among Chinese Elderly

Author

LV, Yue-Bin, YIN, Zhao-Xue, CHEI, Choy-Lye, Brasher, Melanie Sereny, ZHANG, Juan, Kraus, Virginia Byers, QIAN, Frank, SHI, Xiao-Ming, Matchar, David Bruce, and ZENG, Yi

Subjects
Aged, 80 and over, Male, China, Sex Characteristics, Cholesterol, HDL, Longevity, Cholesterol, LDL, Article, Cholesterol, Cognition, Cross-Sectional Studies, Asian People, Reference Values, Linear Models, Odds Ratio, Humans, Female, Triglycerides, Aged
Abstract

The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance among Chinese elderly.A cross-sectional study was implemented in 2012 and data were analyzed using generalized additive models, linear regression models and logistic regression models.Community-based setting in eight longevity areas in China.A total of 2000 elderly aged 65 years and over (mean 85.8±12.0 years) participated in this study.Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) concentration were determined and cognitive impairment was defined as Mini-Mental State Examination (MMSE) score ≤23.There was a significant positive linear association between TC, TG, LDL-C, HDL-C and MMSE score in linear regression models. Each 1 mmol/L increase in TC, TG, LDL-C and HDL-C corresponded to a decreased risk of cognitive impairment in logistic regression models. Compared with the lowest tertile, the highest tertile of TC, LDL-C and HDL-C had a lower risk of cognitive impairment. The adjusted odds ratios and 95% CI were 0.73(0.62-0.84) for TC, 0.81(0.70-0.94) for LDL-C and 0.81(0.70-0.94) for HDL-C. There was no gender difference in the protective effects of high TC and LDL-C levels on cognitive impairment. However, for high HDL-C levels the effect was only observed in women. High TC, LDL-C and HDL-C levels were associated with lower risk of cognitive impairment in the oldest old (aged 80 and older), but not in the younger elderly (aged 65 to 79 years).These findings suggest that cholesterol levels within the high normal range are associated with better cognitive performance in Chinese elderly, specifically in the oldest old. With further validation, low cholesterol may serve a clinical indicator of risk for cognitive impairment in the elderly.

Published
2016

98. Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer

Author

Huo, Dezheng, primary, Feng, Ye, additional, Haddad, Stephen, additional, Zheng, Yonglan, additional, Yao, Song, additional, Han, Yoo-Jeong, additional, Ogundiran, Temidayo O., additional, Adebamowo, Clement, additional, Ojengbede, Oladosu, additional, Falusi, Adeyinka G., additional, Zheng, Wei, additional, Blot, William, additional, Cai, Qiuyin, additional, Signorello, Lisa, additional, John, Esther M., additional, Bernstein, Leslie, additional, Hu, Jennifer J., additional, Ziegler, Regina G., additional, Nyante, Sarah, additional, Bandera, Elisa V., additional, Ingles, Sue A., additional, Press, Michael F., additional, Deming, Sandra L., additional, Rodriguez-Gil, Jorge L., additional, Nathanson, Katherine L., additional, Domchek, Susan M., additional, Rebbeck, Timothy R., additional, Ruiz-Narváez, Edward A., additional, Sucheston-Campbell, Lara E., additional, Bensen, Jeannette T., additional, Simon, Michael S., additional, Hennis, Anselm, additional, Nemesure, Barbara, additional, Leske, M. Cristina, additional, Ambs, Stefan, additional, Chen, Lin S., additional, Qian, Frank, additional, Gamazon, Eric R., additional, Lunetta, Kathryn L., additional, Cox, Nancy J., additional, Chanock, Stephen J., additional, Kolonel, Laurence N., additional, Olshan, Andrew F., additional, Ambrosone, Christine B., additional, Olopade, Olufunmilayo I., additional, Palmer, Julie R., additional, and Haiman, Christopher A., additional

Published
2016
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100. Alcohol Consumption and Breast Cancer Risk among Women in Three Sub-Saharan African Countries

Author

Qian, Frank, primary, Ogundiran, Temidayo, additional, Hou, Ningqi, additional, Ndom, Paul, additional, Gakwaya, Antony, additional, Jombwe, Johashaphat, additional, Morhason-Bello, Imran, additional, Adebamowo, Clement, additional, Ademola, Adeyinka, additional, Ojengbede, Oladosu, additional, Olopade, Olufunmilayo I., additional, and Huo, Dezheng, additional

Published
2014
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