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238 results on '"Quatrale, R"'

52. The PRIAMO study: background, methods and recruitment

Author

Antonini, A, Colosimo, C, Marconi, R, Morgante, L, Barone, P, Priamo, Sg, Abbruzzese, Giovanni, Abrignani, M, Agnetti, V, Antonini Pezzoli, A, Avarello, T, Baratti, M, Bartolomei, L, Bentivoglio, A, Bottacchi, E, Bracco, F, Cannas, A, Capus, L, Ceravolo, M, Ceravolo, R, Ciacci, G, Cicarelli, G, Consoli, D, Cossu, G, Cuomo, T, De Pandis, M, Del Dotto, P, Gaglio, R, Giaccaglini, E, Giglia, L, Guidi, M, Iemolo, F, Lopiano, L, Luciano, R, Manfredi, M, Marini, P, Martinelli, P, Mauro, A, Meco, G, Mucchiut, M, Nastasi, G, Nordera, G, Pacchetti, C, Pederzoli, M, Pennisi, F, Perini, M, Petrone, A, Pontieri, F, Pramstaller, P, Quatrale, R, Scaglioni, A, Scala, R, Simone, P, Soliveri, P, Stanzione, P, Stocchi, F, Trianni, G, Troianiello, B, Volpe, G, Zàppia, M, Zappulla, S., Antonini, A, Colosimo, C, Marconi, R, Morgante, L, Barone, Paolo, PRIAMO study, g. r. o. u. p., Antonino A., Colosimo C., Marconi R., Morgante L., Barone P., on behalf of the PRIAMO study group [.., Martinelli P., and ]

Subjects
Male, Sleep Wake Disorders, medicine.medical_specialty, Pediatrics, Cross-sectional study, prevalence, Neurocognitive Disorders, Comorbidity, Dermatology, epidemiology, incidence, parkinsonism, Cohort Studies, Parkinsonian Disorders, Quality of life, Epidemiology, medicine, Humans, Dementia, Longitudinal Studies, Aged, business.industry, MULTICENTRIC STUDY, Patient Selection, Incidence (epidemiology), Parkinsonism, General Medicine, medicine.disease, Epidemiologic Studies, Psychiatry and Mental health, Cross-Sectional Studies, Autonomic Nervous System Diseases, Italy, Epidemiologic Research Design, MOTOR SYMPTOMS, Quality of Life, Physical therapy, Female, Neurology (clinical), PARKINSON, business, Cohort study
Abstract

PRIAMO (PaRkinson And non Motor symptOms) is an epidemiology study aimed to assess the prevalence and incidence of non-motor symptoms (NMS) in patients with parkinsonism. PRIAMO consists of two phases: (1) a transversal assessment of the prevalence of NMS and (2) a longitudinal observation with two follow-up visits at 12 and 24 months to establish the incidence of NMS. A secondary aim of PRIAMO is to study the relationship between NMS and quality of life. Patients with parkinsonism have been evaluated in 59 Neurology Centres widely distributed throughout Italy. PRIAMO has analysed a total of 1307 patients (out of 1325 initially enrolled). We expect that PRIAMO will substantially help to quantify the burden of NMS in patients with parkinsonism.

Published
2008

70. Le neuropatie diabetiche

Author

Granieri, Enrico Gavino Giuseppe, Quatrale, R., Casetta, Ilaria, and Carreras, M.

Published
1993

76. Emispasmo faciale 'idiopatico'.revisione di una casistica

Author

Paolino, E., Quatrale, R., Marcello, O., Malagù, S., Govoni, Vittorio, Monetti, V. C., Tola, M. R., and Granieri, Enrico Gavino Giuseppe

Subjects
emispasmo facciale idiopatico, casistica, casistica, emispasmo facciale idiopatico, NO
Published
1991

97. Electrical field stimulation of isolated primate sweat glands.

Author

Vitale, G. I., Quatrale, R. P., Giles, P. J., and Birnbaum, J. E.

Subjects
SWEAT gland diseases, ELECTRIC fields, PERSPIRATION, EXCRETION, PRIMATES, DERMATOLOGY
Abstract

An in vitro method is described for inducing secretion in isolated monkey eccrine sweat glands by means of electrical field stimulation (EES). Ultrastructural analyses of these glands revealed unmyelinated nerve fibres surrounding the secretory coils. Numerous small clear vesicles, characteristic of cholinergic nerve terminals, were observed, along with a few which were large and dense-cored. EFS elicited an immediate secretory response which ceased abruptly upon termination of the current. The response was inhibited in a dose-dependent manner by atropine (lC5o I.5 × 10-9 mol/l). Although most glands were completely inhibited by atropine, a minor atropine insensitive component was operative in some preparations. Physostigmine (10 6mol/l) potentiated the response to subthreshold EFS. Lidocaine (3 × 10-4 mol/l) completely and reversibly blocked EFS but had no effect on methacholine(10-6 mol/l) induced secretion. These results confirm that eccrine sweat gland activation is predominantly via cholinergic pathways and that EFS of isolated glands may be a useful model to study the control of secretory function in normal and diseased states. [ABSTRACT FROM AUTHOR]

Published
1986
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98. Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomized, double blind, placebo controlled, phase III study

Author

Lauria, G, Dalla Bella, E, Antonini, G, Borghero, G, Capasso, M, Caponnetto, C, Chiò, A, Corbo, M, Eleopra, R, Fazio, R, Filosto, M, Giannini, F, Granieri, E, La Bella, V, Logroscino, G, Mandrioli, J, Mazzini, L, Monsurrò, Mr, Mora, G, Pietrini, V, Quatrale, R, Rizzi, R, Salvi, F, Siciliano, G, Sorarù, G, Volanti, P, Tramacere, I, Filippini, G, Cazzato, D, Cesnik, E, Groppo, E, Sette, E, Pani, C, Costantino, E, Orlandini, F, Boi, D, Querin, G, D'Ascenzo, C, Sagnelli, A, Piccirillo, G, Aiello, M, Chetta, A, Grassi, A, Lunetta, C, Maestri, E, Padovani, A, Cotelli, M, Todeschini, A, Morino, S, Di Pasquale, A, Latino, P, Casali, S, Battistini, S, Pirrelli, M, Cantello, R, Nasuelli, N, Servo, S, De Gennaro, R, Gastaldo, E, Georgoulopoulou, E, Fini, N, Taiello, Ac, Colletti, T, Calvo, A, Moglia, C, Fuda, G, Marinou, K, Riva, N, Cerri, F, Lopez, Id, De Cicco, D, Battaglia, G, Marcello, N, Rinaldi, M, Scialò, C, Mantero, V, Mascolo, M, Carlesi, C, Caldarazzo Ienco, E, Di Muzio, A, Verriello, L, D'Amico, D, Simone, Il, Tortelli, R, Cortese, R, Bartolomei, I, G., Lauria, E., Dalla Bella, G., Antonini, G., Borghero, M., Capasso, C., Caponnetto, A., Chiò, M., Corbo, R., Eleopra, R., Fazio, M., Filosto, F., Giannini, E., Granieri, V., La Bella, G., Logroscino, J., Mandrioli, L., Mazzini, Monsurro', Maria Rosaria, G., Mora, V., Pietrini, R, Quatrale, R., Rizzi, F., Salvi, G., Siciliano, G., Sorarù, P., Volanti, I., Tramacere, G., Filippini, on behalf of the EPOS Trial Study, Group, Lauria, G., Bella, E. D., Antonini, G., Borghero, G., Capasso, M., Caponnetto, C., Chio, A., Corbo, M., Eleopra, R., Fazio, R., Filosto, M., Giannini, F., Granieri, E., Bella, V. L., Logroscino, G., Mandrioli, J., Mazzini, L., Mora, G., Pietrini, V., Quatrale, R., Rizzi, R., Salvi, F., Siciliano, G., Soraru, G., Volanti, P., Tramacere, I., Filippini, G., Lauria, G, Dalla Bella, Eleonora, Antonini, G, Borghero, G, Capasso, M, Caponnetto, C, Chiò, A, Corbo, M, Eleopra, R, Fazio, R, Filosto, M, Giannini, F, Granieri, E, LA BELLA, V, Logroscino, G, Mandrioli, J, Mazzini, L, Monsurrò, Maria Rosaria, Mora, G, Pietrini, V, Quatrale, R, Rizzi, R, Salvi, F, Siciliano, G, Sorarù, G, Volanti, P, and Tramacere Irene, Filippini, G.

Subjects
Male, Gastroenterology, law.invention, Randomized controlled trial, law, Amyotrophic lateral sclerosis, MOTOR NEURON DISEASE, education.field_of_study, Recombinant Protein, Middle Aged, Recombinant Proteins, Treatment Outcome, Psychiatry and Mental Health, Neuromuscular, Settore MED/26 - Neurologia, Female, erythropoietyn, clinical trial, medicine.drug, Human, ALS, Adult, Aged, Amyotrophic Lateral Sclerosis, Double-Blind Method, Erythropoietin, Humans, medicine.medical_specialty, Population, Socio-culturale, Placebo, Double blind, Arts and Humanities (miscellaneous), Epoetin Alfa, Neurology (clinical), Surgery, Internal medicine, medicine, education, business.industry, Epoetin alfa, medicine.disease, Clinical trial, business, Amyotrophic Lateral Sclerosi
Abstract

Objective To assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS). Methods Patients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned (1:1) to receive intravenous rhEPO 40 000 IU or placebo fortnightly as add-on treatment to riluzole 100 mg daily for 12 months. The primary composite outcome was survival, tracheotomy or >23 h non-invasive ventilation (NIV). Secondary outcomes were ALSFRS-R, slow vital capacity (sVC) and quality of life (ALSAQ-40) decline. Tolerability was evaluated analysing adverse events (AEs) causing withdrawal. The randomisation sequence was computer-generated by blocks, stratified by centre, disease severity (ALSFRS-R cut-off score of 33) and onset (spinal or bulbar). The main outcome analysis was performed in all randomised patients and by intentionto-treat for the entire population and patients stratified by severity and onset. The study is registered, EudraCT 2009-016066-91. Results We randomly assigned 208 patients, of whom 5 (1 rhEPO and 4 placebo) withdrew consent and 3 ( placebo) became ineligible (retinal thrombosis, respiratory insufficiency, SOD1 mutation) before receiving treatment; 103 receiving rhEPO and 97 placebo were eligible for analysis. At 12 months, the annualised rate of death (rhEPO 0.11, 95% CI 0.06 to 0.20; placebo: 0.08, CI 0.04 to 0.17), tracheotomy or >23 h NIV (rhEPO 0.16, CI 0.10 to 0.27; placebo 0.18, CI 0.11 to 0.30) did not differ between groups, also after stratification by onset and ALSFRS-R at baseline. Withdrawal due to AE was 16.5% in rhEPO and 8.3% in placebo. No differences were found for secondary outcomes. Conclusions RhEPO 40 000 IU fortnightly did not change the course of ALS.

99. Cation distributions across the larval and pupal midgut of the lepidopteran, Hyalophora cecropia, in vivo

Author

Harvey, W. R., Wood, J. L., Quatrale, R. P., and Jungreis, A. M.

Abstract

The levels of potassium, sodium, magnesium and calcium in leaves, midgut contents, midgut tissue, and blood were analysed in seven developmental stages between feeding, fourth-instar larvae and new pupae of the Cecropia silkworm. Three dramatic changes in cation levels were found: the K level in the contents drops from 284 ±51 mEquiv./l tissue water in the fifth-instar larva to 51 ± 6 mEquiv./l in the new pupa ; the Mg level in the midgut tissue increases from 28 ± 3 mEquiv./l at the time of gut evacuation to 1093 ± 104 mEquiv./l in the new pupa; and the Ca level in the contents drops temporarily from 56 ± 12 mEquiv./l in the feeding fourth instar larva to 17 ± 5 mEquiv./l in the new fifth instar larva. The Na level was never higher than 2·8 ± 0·5 mEquiv./l. The relative levels of the four cations were different for each tissue studied, but each tissue maintained the same relative levels during the developmental stages studied. The sequences are: leaf, Ca > K > Mg > Na; midgut contents, K ⪢ Ca > Mg > Na; midgut tissue, K ⪢> Mg > Ca > Na; and blood, Mg ⪢ K > Ca > Na. There were three large concentration gradients across the midgut ; the K level in the midgut contents is approximately 10 times the level in blood; the Mg level in contents is one-half to one-sixth the level in blood; and the Ca level in contents is 3—4 times the level in blood. The K gradient and the Ca gradient are opposed and the Mg gradient is favoured by the electrical gradient across the larval midgut, the contents being 100 mV positive with respect to the blood. The K gradient and the electrical gradient are not present across the pupal midgut while the Mg gradient and the Ca gradient persist. The K gradient is presumably maintained by the midgut K pump, the Mg gradient is aided by the midgut Mg pump, and the Ca gradient suggests that the midgut may possess a Ca pump.

Published
1975
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100. Profilo clinico-epidemiologico della sclerosi multipla nella provincia di Ferrara

Author

Granieri, Enrico Gavino Giuseppe, Tola, M. R., Monetti, V. C., Munerati, V., Panarelli, M., Mazzantti, B., Luongo, L., Paolino, E., Carreras, M., Altobelli, A., Quatrale, R., Casetta, I., Caniatti, L., Vicentini, V., Tralli, G., De Bastiani, P. L., and Di Palma, G.

Subjects
Ambientale, sclerosi multipla epidemiologia prevalenza incidenza decorso
Published
1986

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