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59. Self-referencing a 10 GHz Electro-optic Comb

Author

Cole, D. C., primary, Beha, K., additional, Baynes, F. N., additional, Del’Haye, P., additional, Rolland, A., additional, Fortier, T. M., additional, Quinlan, F., additional, Diddams, S. A., additional, and Papp, S. B., additional

Published
2015
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61. Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation

Author

Alison E. Meyer, Quinlan Furumo, Cary Stelloh, Alex C. Minella, and Sridhar Rao

Subjects
Fbw7, P53, Breast cancer, Tumor cell biology, Cell cycle, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of FBXW7 in breast cancer has been hypothesized to result in the accumulation of oncogenic transcription factors that are master regulators of proliferation, apoptosis, and ultimately transformation. Despite this, the direct effect of Fbw7 loss on mammary gland morphology and tumorigenesis has not been examined. Here, we demonstrate that conditional deletion of Fbxw7 in murine mammary tissue initiates breast tumor development and also results in lactation and involution defects. Further, while Fbxw7 loss results in the overexpression of Notch1-ICD, c-Jun, cyclin E, and c-Myc, the downstream transcription factor pathways associated with c-Myc and cyclin E are the most dysregulated, including at the single-cell level. These pathways are dysregulated early after Fbxw7 loss, and their sustained loss results in tumorigenesis and reinforced c-Myc and cyclin E-E2F pathway disruption. We also find that loss of Fbxw7 is linked to the acquisition of Trp53 mutations, similar to the mutational spectrum observed in patients. Our results demonstrate that the loss of Fbxw7 promotes the acquisition of Trp53 mutations and that the two cooperate in breast tumor development. Targeting c-Myc, E2F, or p53 may therefore be a beneficial treatment strategy for FBXW7-altered breast cancer patients.

Published
2020
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62. A Near Infrared Laser Frequency Comb for High Precision Doppler Planet Surveys

Author

Osterman, S., Diddams, S., Quinlan, F., Bally, J., Ge, J., Ycas, G., Osterman, S., Diddams, S., Quinlan, F., Bally, J., Ge, J., and Ycas, G.

Abstract

We discuss the laser frequency comb as a near infrared astronomical wavelength reference, and describe progress towards a near infrared laser frequency comb at the National Institute of Standards and Technology and at the University of Colorado where we are operating a laser frequency comb suitable for use with a high resolution H band astronomical spectrograph., Comment: 8 pages, 5 figures. Conference Proceedings, New Technologies for Probing the Diversity of Brown Dwarfs and Exoplanets, Shanghai, China, 19-24 July, 2009. Submitted to Eur. Phys. J. Conferences

Published
2010
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63. Characterization of Noise Properties in Photodetectors: A Step Toward Ultra-Low Phase Noise Microwaves

Author

COLORADO UNIV AT BOULDER DEPT OF PHYSICS, Taylor, J., Quinlan, F., Diddams, S., COLORADO UNIV AT BOULDER DEPT OF PHYSICS, Taylor, J., Quinlan, F., and Diddams, S.

Abstract

Very-low-noise microwave signals are desirable for many state-of-the-art applications, including many types of radar and imaging systems. However, even state-of-the-art rf oscillator technology for producing signals into the tens of gigahertz range does not generate signals with low enough phase noise for these important systems to work to their full potential. A new approach for achieving microwave signals with ultra-low phase noise involves using an optical frequency divider that has as its reference a narrow-linewidth CW laser. Femtosecond laser frequency combs provide an effective and efficient way to take an ultra-stable optical frequency reference and divide the signal down into the microwave region. In order to convert optical pulses into a usable rf signal, one must use high-speed photodetection; unfortunately, excess phase noise from both technical and fundamental sources can arise in the photodetection process. In order to ultimately minimize the noise effects of the photodetector, we must first characterize some of the known sources for noise arising in these devices. In this paper, we will study two sources of excess noise in highspeed photodiodes -- power-to-phase conversion and shot noise. The noise performance of each device will give us clues as to the nature of the sources, their effect on the output signal, and what design features of the photodiode minimize these noise effects., Presented at the Annual Precise Time and Time Interval (PTTI) Systems and Applications Meeting (41st), held in Santa Ana, Pueblo, NM, on 16-19 Nov 2009. Published in the proceedings of the meeting, p339-348, 2009. Prepared in collaboration with National Institute of Standards and Technology, Boulder, CO. The original document contains color images.

Published
2009

79. Optical frequency combs for low phase noise microwave generation

Author

Quinlan, F., primary, Fortier, T. M., additional, Kirchner, M. S., additional, Taylor, J. A., additional, Bergquist, J. C., additional, Rosenband, T., additional, Lemke, N., additional, Ludlow, A., additional, Jiang, Y., additional, Oates, C. W., additional, and Diddams, S. A., additional

Published
2011
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81. Noise limitations in microwave generation from optical references

Author

Quinlan, F., primary, Fortier, T. M., additional, Kirchner, M. S., additional, Taylor, J. A., additional, Bergquist, J. C., additional, Rosenband, T., additional, Lemke, N., additional, Ludlow, A., additional, Jiang, Y., additional, Oates, C. W., additional, and Diddams, S. A., additional

Published
2011
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87. Low jitter optical and microwave synthesis with frequency combs

Author

Diddams, S. A., primary, Fortier, T., additional, Kirchner, M. S., additional, Meyer, S. A., additional, Quinlan, F. J., additional, Taylor, J., additional, Bergquist, J.C., additional, Jiang, Y., additional, Ludlow, A., additional, Oates, C. W., additional, and Rosenband, T., additional

Published
2010
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