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348 results on '"Rabson, A B"'

51. Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Author

Newman, Jenna H., primary, Chesson, C. Brent, additional, Herzog, Nora L., additional, Bommareddy, Praveen K., additional, Aspromonte, Salvatore M., additional, Pepe, Russell, additional, Estupinian, Ricardo, additional, Aboelatta, Mones M., additional, Buddhadev, Stuti, additional, Tarabichi, Saeed, additional, Lee, Michael, additional, Li, Shengguo, additional, Medina, Daniel J., additional, Giurini, Eileena F., additional, Gupta, Kajal H., additional, Guevara-Aleman, Gabriel, additional, Rossi, Marco, additional, Nowicki, Christina, additional, Abed, Abdulkareem, additional, Goldufsky, Josef W., additional, Broucek, Joseph R., additional, Redondo, Raquel E., additional, Rotter, David, additional, Jhawar, Sachin R., additional, Wang, Shang-Jui, additional, Kohlhapp, Frederick J., additional, Kaufman, Howard L., additional, Thomas, Paul G., additional, Gupta, Vineet, additional, Kuzel, Timothy M., additional, Reiser, Jochen, additional, Paras, Joyce, additional, Kane, Michael P., additional, Singer, Eric A., additional, Malhotra, Jyoti, additional, Denzin, Lisa K., additional, Sant’Angelo, Derek B., additional, Rabson, Arnold B., additional, Lee, Leonard Y., additional, Lasfar, Ahmed, additional, Langenfeld, John, additional, Schenkel, Jason M., additional, Fidler, Mary Jo, additional, Ruiz, Emily S., additional, Marzo, Amanda L., additional, Rudra, Jai S., additional, Silk, Ann W., additional, and Zloza, Andrew, additional

Published
2019
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53. Inhibition of HIV-1 replication by a Tat RNA-binding domain peptide analog

Author

Choudhury, Indrani, Wang, Jihong, Rabson, Arnold B., Stein, Steven, Pooyan, Shahriar, Stein, Stanley, and Leibowitz, Michael J.

Subjects
Peptides -- Physiological aspects, HIV (Viruses) -- Reproduction, Health
Abstract

A synthetic peptide that may block HIV reproduction is described. The peptide, called Tat10-biotin, resembles the HIV Tat protein. This protein binds to viral RNA and begins the viral reproductive process. Tat10-biotin can also bind to viral RNA and block viral reproduction. The peptide inhibited HIV reproduction in cell culture and also suppressed the production of the viral enzyme reverse transcriptase, which is required for viral reproduction.

Published
1998

54. Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.

Author

Springer, Lauren E., Patton, John B., Zhan, Tingting, Rabson, Arnold B., Lin, Hsin-Ching, Manser, Tim, Lok, James B., Hess, Jessica A., and Abraham, David

Subjects
MIXED infections, CORD blood, CYTOKINES, BLOOD cells, STEM cells
Abstract

Viral and parasitic coinfections are known to lead to both enhanced disease progression and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting in a significant incidence of coinfection. Independently, HTLV-1 induces a Th1 response and S. stercoralis infection induces a Th2 response. However, coinfection with the two pathogens has been associated with the development of S. stercoralis hyperinfection and an alteration of the Th1/Th2 balance. In this study, a model of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical cord blood hematopoietic stem cell engrafted humanized mice was established. An increased level of mortality was observed in the HTLV-1 and coinfected animals when compared to the S. stercoralis infected group. The mortality was not correlated with proviral loads or total viral RNA. Analysis of cytokine profiles showed a distinct shift towards Th1 responses in HTLV-1 infected animals, a shift towards Th2 cytokines in S. stercoralis infected animals and elevated TNF-α responses in coinfected animals. HTLV-1 infected and coinfection groups showed a significant, yet non-clonal expansion of the CD4+CD25+ T-cell population. Numbers of worms in the coinfection group did not differ from those of the S. stercoralis infected group and no autoinfective larvae were found. However, infective larvae recovered from the coinfection group showed an enhancement in growth, as was seen in mice with S. stercoralis hyperinfection caused by treatment with steroids. Humanized mice coinfected with S. stercoralis and HTLV-1 demonstrate features associated with human infection with these pathogens and provide a unique opportunity to study the interaction between these two infections in vivo in the context of human immune cells. Author summary: Human infections with the virus HTLV-1 and the nematode Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting in a significant incidence of coinfection. The coincident infections result in S. stercoralis hyperinfection and an alteration of the balance of the immune responses to the virus and to the worm. In this study, a novel model of HTLV-1 and S. stercoralis coinfection was established in humanized mice. Mortality was increased in the HTLV-1 and coinfected animals as compared to the S. stercoralis infected group. Analysis of cytokine profiles showed a distinct shift towards Th1 responses in HTLV-1 infected animals, a shift towards Th2 cytokines in S. stercoralis infected animals and elevated TNF-α responses in coinfected animals. Numbers of worms in the coinfection group did not differ from those of the S. stercoralis infected group, however, infective larvae recovered from the coinfection group showed a significant enhancement in growth. Humanized mice coinfected with S. stercoralis and HTLV-1 demonstrate features associated with human infection with these pathogens and provide a unique opportunity to study the interaction between these two infections. [ABSTRACT FROM AUTHOR]

Published
2021
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55. Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

Author

Rabson Arnold B, Leibowitz Michael J, Debrah Olivia, Pooyan Shahriar, Gunaseelan Simi, Zhang Xiaoping, Wan Li, Stein Stanley, and Sinko Patrick J

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Current anti-AIDS therapeutic agents and treatment regimens can provide a dramatically improved quality of life for HIV-positive people, many of whom have no detectable viral load for prolonged periods of time. Despite this, curing AIDS remains an elusive goal, partially due to the occurrence of drug resistance. Since the development of resistance is linked to, among other things, fluctuating drug levels, our long-term goal has been to develop nanotechnology-based drug delivery systems that can improve therapy by more precisely controlling drug concentrations in target cells. The theme of the current study is to investigate the value of combining AIDS drugs and modifiers of cellular uptake into macromolecular conjugates having novel pharmacological properties. Results Bioconjugates were prepared from different combinations of the approved drug, saquinavir, the antiviral agent, R.I.CK-Tat9, the polymeric carrier, poly(ethylene) glycol and the cell uptake enhancer, biotin. Anti-HIV activities were measured in MT-2 cells, an HTLV-1-transformed human lymphoid cell line, infected with HIV-1 strain Vbu 3, while parallel studies were performed in uninfected cells to determine cellular toxicity. For example, R.I.CK-Tat9 was 60 times more potent than L-Tat9 while the addition of biotin resulted in a prodrug that was 2850 times more potent than L-Tat9. Flow cytometry and confocal microscopy studies suggest that variations in intracellular uptake and intracellular localization, as well as synergistic inhibitory effects of SQV and Tat peptides, contributed to the unexpected and substantial differences in antiviral activity. Conclusion Our results demonstrate that highly potent nanoscale multi-drug conjugates with low non-specific toxicity can be produced by combining moieties with anti-HIV agents for different targets onto macromolecules having improved delivery properties.

Published
2006
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58. HIV virology: implications for the pathogenesis of HIV infection

Author

Rabson, Arnold B.

Subjects
HIV (Viruses) -- Physiological aspects, HIV infection -- Development and progression, HIV (Viruses) -- Genetic aspects, Health
Abstract

Infection by the human immunodeficiency virus (HIV) causes a wide variety of disease ranging from positive blood tests for HIV infection without accompanying symptoms, to the extensive deterioration of the immune system. Characteristics of the HIV life cycle may influence the disease process of HIV infection. HIV specifically attacks and destroys CD4 cells, a type of immune cell. CD4 cells are involved in the production of immune proteins called antibodies, another type of immune cell. Antibodies are produced in the presence of a foreign substance such as a virus, and can specifically bind and inactivate the virus. Hence, HIV destruction of CD4 cells decrease the production of antibodies and reduce the ability of the patient to fight viral infection. The viral envelope, or outer structure of the virus, consists of antigens, components that can activate an immune response. Because the viral envelope of HIV is highly variable, the ability of the patient's immune response to control HIV infection is limited. The persistence of HIV results from the ability of the virus to integrate its genetic material into the cells of the infected individual. This viral genetic material can then be activated by cell signals that control normal immune cell activation. In this way, HIV replication is be linked with the normal cell functions of the patient. These characteristics contribute to the chronic and progressive nature of HIV infection. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

65. Requirement of Bccipfor the Regeneration of Intestinal Progenitors

Author

Lu, Huimei, Ye, Caiyong, Liu, Jingmei, Rabson, Arnold B., Verzi, Michael, De, Subhajyoti, and Shen, Zhiyuan

Abstract

BCCIP was originally identified as a BRCA2 and CDKN1A/p21 interaction protein. Although a partial loss of BCCIPfunction is sufficient to trigger genomic instability and tumorigenesis, complete deletion of BCCIPis lethal to cells. Using Rosa26-CreERT2 mouse models, we found that induced Bccipdeletion in adult mice caused an acute intestinal epithelial denudation that cannot be relieved by co-deletion of Trp53. The critical role of Bccipin intestine epithelial renewal was verified with a Villin-CreERT2 mouse model. The epithelium degeneration was associated with a rapid loss of the proliferative capability of the crypt progenitor cells in vivo, lack of crypt base columnar stem cell markers, and a failure of in vitrocrypt organoid growth. RNA-Seq analysis of freshly isolated intestinal crypt cells showed that Bccipdeletion caused an overwhelming down-regulation of genes involved in mitotic cell division but an up-regulation of genes involved in apoptosis and stress response to microbiomes. Our data not only indicate that intestinal epithelium is the most sensitive tissue to whole-body deletion of Bccipbut also point to Bccipas a novel and critical factor for the proliferation of the intestinal progenitors. These findings have significant implications for understanding why a hypomorphic loss of BCCIP functions is more relevant to tumorigenesis.

Published
2021
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69. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells

Author

Shou, P, primary, Chen, Q, additional, Jiang, J, additional, Xu, C, additional, Zhang, J, additional, Zheng, C, additional, Jiang, M, additional, Velletri, T, additional, Cao, W, additional, Huang, Y, additional, Yang, Q, additional, Han, X, additional, Zhang, L, additional, Wei, L, additional, Rabson, A B, additional, Chin, Y E, additional, Wang, Y, additional, and Shi, Y, additional

Published
2016
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71. Choline-magnesium trisalicylate modulates acute myelogenous leukemia gene expression during induction chemotherapy.

Author

Medina, Daniel, David, Kevin, Lin, Yong, Schaar, Dale, Patel, Vimal, Gharibo, Mecide, Bannerji, Rajat, Walton, Kelly, Aisner, Joseph, Rabson, Arnold B., and Strair, Roger

Subjects
CLINICAL trials, NF-kappa B, GENE expression, ACUTE myeloid leukemia, CANCER chemotherapy, CHOLINE, THERAPEUTICS
Abstract

The article discusses a randomized phase-two study which determines whether changes in nuclear factor kappa B (NF-ƘB) activity corresponded with changes in the expression of NF-ƘB target genes. In the said study, the newly diagnosed patients with acute myelogenous leukemia (AML) eligible for standard induction chemotherapy were assigned to choline magnesium trisalicylate (CMT) or no CMT.

Published
2017
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73. This title is unavailable for guests, please login to see more information.

Author

Fu, Jing, Qu, Zhaoxia, Yan, Pengrong, Li, Shirong, Song, Xinxin, Ishikawa, Chie, Aqeilan, Rami I, Mori, Naoki, Rabson, Arnold B, Xiao, Gutian, Fu, Jing, Qu, Zhaoxia, Yan, Pengrong, Li, Shirong, Song, Xinxin, Ishikawa, Chie, Aqeilan, Rami I, Mori, Naoki, Rabson, Arnold B, and Xiao, Gutian

Published
2011

74. A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors

Author

DING, NING, primary, CUI, XIAO-XING, additional, GAO, ZHI, additional, HUANG, HUARONG, additional, WEI, XINGCHUAN, additional, DU, ZHIYUN, additional, LIN, YONG, additional, SHIH, WEICHUNG JOE, additional, RABSON, ARNOLD B., additional, CONNEY, ALLAN H., additional, HU, CHUNHONG, additional, and ZHENG, XI, additional

Published
2014
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76. An Osteopontin-Integrin Interaction Plays a Critical Role in Directing Adipogenesis and Osteogenesis by Mesenchymal Stem Cells

Author

Chen, Qing, primary, Shou, Peishun, additional, Zhang, Liying, additional, Xu, Chunliang, additional, Zheng, Chunxing, additional, Han, Yanyan, additional, Li, Wenzhao, additional, Huang, Yin, additional, Zhang, Xiaoren, additional, Shao, Changshun, additional, Roberts, Arthur I., additional, Rabson, Arnold B., additional, Ren, Guangwen, additional, Zhang, Yanyun, additional, Wang, Ying, additional, Denhardt, David T., additional, and Shi, Yufang, additional

Published
2014
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78. ‘Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption’

Author

De Lorenzo, Mariana S., primary, Chen, Wen, additional, Baljinnyam, Erdene, additional, Carlini, María J., additional, La Perle, Krista, additional, Bishop, Sanford P., additional, Wagner, Thomas E., additional, Rabson, Arnold B., additional, Vatner, Dorothy E., additional, Puricelli, Lydia I., additional, and Vatner, Stephen F., additional

Published
2013
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95. Atorvastatin and Celecoxib Inhibit Prostate PC-3 Tumors in Immunodeficient Mice

Author

Zheng, Xi, primary, Cui, Xiao-Xing, additional, Avila, Gina E., additional, Huang, Mou-Tuan, additional, Liu, Yue, additional, Patel, Jagruti, additional, Kong, Ah Ng Tony, additional, Paulino, Raphael, additional, Shih, Weichung Joe, additional, Lin, Yong, additional, Rabson, Arnold B., additional, Reddy, Bandaru S., additional, and Conney, Allan H., additional

Published
2007
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96. Effects of 12-O-Tetradecanoylphorbol-13-acetate (TPA) in Combination with Paclitaxel (Taxol) on Prostate Cancer LNCaP Cells Cultured In vitro or Grown as Xenograft Tumors in Immunodeficient Mice

Author

Zheng, Xi, primary, Chang, Richard L., additional, Cui, Xiao-Xing, additional, Avila, Gina E., additional, Hebbar, Vidya, additional, Garzotto, Mark, additional, Shih, Weichung Joe, additional, Lin, Yong, additional, Lu, Shou-En, additional, Rabson, Arnold B., additional, Kong, Ah Ng Tony, additional, and Conney, Allan H., additional

Published
2006
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98. Inhibitory Effects of 12-O-Tetradecanoylphorbol-13-acetate Alone or in Combination with All-transRetinoic Acid on the Growth of Cultured Human Pancreas Cancer Cells and Pancreas Tumor Xenografts in Immunodeficient Mice

Author

Avila, Gina E., primary, Zheng, Xi, additional, Cui, Xiao Xing, additional, Ryan, Amanda D., additional, Hansson, Annette, additional, Suh, Junghan, additional, Rabson, Arnold B., additional, Chang, Richard L., additional, Shih, Weichung Joe, additional, Lin, Yong, additional, Crowell, Pamela, additional, Lu, Yao Ping, additional, Lou, You Rong, additional, and Conney, Allan H., additional

Published
2005
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