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54. Clinical features of patients who had two COVID-19 episodes: a European multicentre case series

Author

Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, Radulesco, Thomas, Michel, Justin, Vaira, Luigi, Le Bon, Serge-Daniel, Horoi, Mihaela, Falanga, Chiara, Barillari, Maria Rosaria, Hans, Stéphane, Tucciarone, Manuel, Saussez, Sven, Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, Radulesco, Thomas, Michel, Justin, Vaira, Luigi, Le Bon, Serge-Daniel, Horoi, Mihaela, Falanga, Chiara, Barillari, Maria Rosaria, Hans, Stéphane, Tucciarone, Manuel, and Saussez, Sven

Abstract

Objective: To investigate the clinical features of patients who had two demonstrated coronavirus disease 2019 (COVID-19) episodes. Methods: Data of patients with both COVID-19 episodes were recruited from 22 March to 27 December 2020. The following outcomes were studied: epidemiological, comorbidities, prevalence and severity of general and otolaryngological symptom, olfactory, aroma, and gustatory dysfunctions. A comparison between first and second episodes was performed. Results: Forty-five patients reported having two confirmed COVID-19 episodes. The majority of patients had mild infections in both episodes. The second clinical episode was significantly similar to the first. The symptom duration of the second episode was shorter than the first. The occurrence of loss of smell was unpredictable from the first to the second episode. Conclusion: The recurrence of COVID-19 symptoms is associated with a similar clinical picture than the first episode in patients with initial mild-to-moderate COVID episode. The pathophysiological mechanisms underlying the development of second episode remain uncertain and may involve either true reinfection or virus reactivation from sanctuaries., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

55. Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases

Author

Dahan, Laurie Saloner, primary, Giorgi, Roch, additional, Vergez, Sébastien, additional, Le Taillandier de Gabory, Ludovic, additional, Costes-Martineau, Valérie, additional, Herman, Philippe, additional, Poissonnet, Gilles, additional, Mauvais, Olivier, additional, Malard, Olivier, additional, Garrel, Renaud, additional, Uro-Coste, Emmanuelle, additional, Barry, Béatrix, additional, Bach, Christine, additional, Chevalier, Dominique, additional, Mouawad, Francois, additional, Merol, Jean-Claude, additional, Bastit, Vianney, additional, Thariat, Juliette, additional, Gilain, Laurent, additional, Dufour, Xavier, additional, Righini, Christian-Adrien, additional, Moya-Plana, Antoine, additional, Even, Caroline, additional, Radulesco, Thomas, additional, Michel, Justin, additional, Baujat, Bertrand, additional, Fakhry, Nicolas, additional, Albert, S., additional, Andry, G., additional, Babin, E., additional, Bach, C., additional, Badet, J.-M., additional, Badoual, C., additional, Baglin, A.C., additional, Banal, A., additional, Barry, B., additional, Baudin, E., additional, Baujat, B., additional, Bensadoun, R.J., additional, Bertolus, C., additional, Bessède, J.-P., additional, Blanchard, D., additional, Borel, C., additional, Bozorg-Grayeli, A., additional, Breheret, R., additional, Breton, P., additional, Brugel, L., additional, Calais, G., additional, Casiraghi, O., additional, Cassagnau, E., additional, Castillo, L., additional, Ceruse, P., additional, Chabolle, F., additional, Chevalier, D., additional, Chobaut, J.C., additional, Choussy, O., additional, Cosmidis, A., additional, Coste, A., additional, Costes, V., additional, Crampette, L., additional, Darrouzet, V., additional, Demez, P., additional, Dessi, P., additional, Devauchelle, B., additional, Dolivet, G., additional, Dubrulle, F., additional, Duflo, S., additional, Dufour, X., additional, Faivre, S., additional, Fakhry, N., additional, Ferron, C., additional, Floret, F., additional, de Gabory, L., additional, Garrel, R., additional, Geoffrois, L., additional, Gilain, L., additional, Giovanni, A., additional, Girod, A., additional, Guerrier, B., additional, Hans, S., additional, Herman, P., additional, Hofman, P., additional, Housset, M., additional, Jankowski, R., additional, Jegoux, F., additional, Juliéron, M., additional, Kaminsky, M.-C., additional, Kolb, F., additional, St Guily, J. Lacau, additional, Laccoureye, L., additional, Lallemant, B., additional, Lang, P., additional, Lartigau, E., additional, Lavieille, J.-P., additional, Lefevre, M., additional, Leroy, X., additional, Malard, O., additional, Massip, F., additional, Mauvais, O., additional, Merol, J.-C., additional, Michel, J., additional, Mom, T., additional, Morinière, S., additional, de Monès, E., additional, Moulin, G., additional, Noel, G., additional, Poissonnet, G., additional, Prades, J.-M., additional, Radulesco, T., additional, de Raucourt, D., additional, Reyt, E., additional, Righini, C., additional, Robin, Y. Marie, additional, Rolland, F., additional, Ruhin, B., additional, Sarroul, N., additional, Schultz, P., additional, Serrano, E., additional, Sterkers, O., additional, Strunski, V., additional, Sudaka, A., additional, Tassart, M., additional, Testelin, S., additional, Thariat, J., additional, Timochenko, A., additional, Toussaint, B., additional, Coste, E. Uro, additional, Valette, G., additional, Van den Abbeele, T., additional, Varoquaux, A., additional, Veillon, F., additional, Vergez, S., additional, and Wassef, M., additional

Published
2021
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56. Intra-Individual Aging of the Facial Skeleton

Author

Fourgeot, Eugénie, primary, Graillon, Nicolas, additional, Savoldelli, Charles, additional, Dessi, Patrick, additional, Adalian, Pascal, additional, Michel, Justin, additional, and Radulesco, Thomas, additional

Published
2021
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57. Is minor surgery safe during the COVID-19 pandemic? A multi-disciplinary study

Author

Baboudjian, Michael, primary, Mhatli, Mehdi, additional, Bourouina, Adel, additional, Gondran-Tellier, Bastien, additional, Anastay, Vassili, additional, Perez, Lea, additional, Proye, Pauline, additional, Lavieille, Jean-Pierre, additional, Duchateau, Fanny, additional, Agostini, Aubert, additional, Wazne, Yann, additional, Sebag, Frederic, additional, Foletti, Jean-Marc, additional, Chossegros, Cyrille, additional, Raoult, Didier, additional, Touati, Julian, additional, Chagnaud, Christophe, additional, Michel, Justin, additional, Bertrand, Baptiste, additional, Giovanni, Antoine, additional, Radulesco, Thomas, additional, Sartor, Catherine, additional, Fournier, Pierre-Edouard, additional, and Lechevallier, Eric, additional

Published
2021
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59. Clinical and epidemiological characteristics of 1420 European patients with mild‐to‐moderate coronavirus disease 2019

Author

Lechien, Jerome R., Chiesa‐Estomba, Carlos M., Place, Sammy, Van Laethem, Yves, Cabaraux, Pierre, Mat, Quentin, Huet, Kathy, Plzak, Jan, Horoi, Mihaela, Hans, Stéphane, Rosaria Barillari, Maria, Cammaroto, Giovanni, Fakhry, Nicolas, Martiny, Delphine, Ayad, Tareck, Jouffe, Lionel, Hopkins, Claire, Saussez, Sven, Blecic, Serge, De Siati, Daniele R., Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journe, Fabrice, Hsieh, Julien, Ris, Laurence, El Afia, Fahd, Harmegnies, Bernard, Distinguin, Lea, Chekkoury‐Idrissi, Younes, Circiu, Marta, Lavigne, Philippe, Lopez Delgado, Irene, Calvo‐Henriquez, Christian, Falanga, Chiara, Coppee, Frederique, Le Bon, Serge Daniel, Rodriguez, Alexandra, Dequanter, Didier, Cornelis, Jean‐Philippe, Vergez, Sebastien, Koenen, Lukas, Giuditta, Mannelli, Molteni, Gabriele, Tucciarone, Manuel, Radulesco, Thomas, Khalife, Mohamad, Fourneau, Anne‐Francoise, Cherifi, Soraya, Manto, Mario, Michel, Justin, Mannelli, Giuditta, Cantarella, Giovanna, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Assistance Publique - Hôpitaux de Marseille (APHM), Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), We would like to thank Bayesia (BayesiaLab?, Chang?, France) for the Network Analysis, Jean-Louis Vincent and Michel Van Haeverbeek for the review of the paper or their useful comments, the heads of the Hospitals, which have been involved in the study, for their help in the rapid conduction of the study and the agreement of ethics committees, the European Press/Media (i.e. Le Monde, La Libre, Le Soir, MediQuality, MedScape, and Le Specialiste) for their help in the spread of the information about the study, and FRMH & UMONS for the grant and the support., Lechien, J. R., Chiesa-Estomba, C. M., Place, S., Van Laethem, Y., Cabaraux, P., Mat, Q., Huet, K., Plzak, J., Horoi, M., Hans, S., Barillari, M. R., Cammaroto, G., Fakhry, N., Martiny, D., Ayad, T., Jouffe, L., Hopkins, C., Saussez, S., Blecic, S., De Siati, D. R., Leich, P., Souchay, C., Rossi, C., Journe, F., Hsieh, J., Ris, L., El Afia, F., Harmegnies, B., Distinguin, L., Chekkoury-Idrissi, Y., Circiu, M., Lavigne, P., Lopez Delgado, I., Calvo-Henriquez, C., Falanga, C., Coppee, F., Le Bon, S. D., Rodriguez, A., Dequanter, D., Cornelis, J. -P., Vergez, S., Koenen, L., Giuditta, M., Molteni, G., Tucciarone, M., Radulesco, T., Khalife, M., Fourneau, A. -F., Cherifi, S., Manto, M., Michel, J., Mannelli, G., and Cantarella, G.

Subjects
0301 basic medicine, myalgia, Male, medicine, Original, [SDV]Life Sciences [q-bio], coronavirus, symptoms, Disease, epidemiological, 030204 cardiovascular system & hematology, patients, clinical, Olfaction Disorders, Taste Disorders, 0302 clinical medicine, Epidemiology, Sore throat, Prevalence, Nose, Age Factors, Headache, Middle Aged, 3. Good health, Europe, medicine.anatomical_structure, COVID-19, Female, patient, medicine.symptom, Symptom Assessment, Coronavirus Infections, Sex characteristics, Adult, medicine.medical_specialty, Pneumonia, Viral, 03 medical and health sciences, Betacoronavirus, Sex Factors, Throat, Internal medicine, Internal Medicine, Humans, Pandemics, covid‐19, rhinorrhea, business.industry, SARS-CoV-2, Bayes Theorem, Myalgia, coronaviru, 030104 developmental biology, business
Abstract

International audience; Background: The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown. Objective: To study the clinical presentation of COVID-19 in Europe. Methods: Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes. Results: A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients. Conclusion: The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.

Published
2020
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60. Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report

Author

Lechien, Jérôme, Michel, Justin, Radulesco, Thomas, Chiesa-Estomba, Carlos Miguel, Vaira, Luigi, De Riu, Giacomo, Sowerby, Leigh, Hopkins, Claire, Saussez, Sven, Lechien, Jérôme, Michel, Justin, Radulesco, Thomas, Chiesa-Estomba, Carlos Miguel, Vaira, Luigi, De Riu, Giacomo, Sowerby, Leigh, Hopkins, Claire, and Saussez, Sven

Abstract

Objectives/Hypothesis: To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID-19). Study Design: Prospective non controlled study. Methods: Sixteen COVID-19 patients were recruited. The epidemiological and clinical data were extracted. Nasal complaints were assessed through the 22-item Sino-Nasal Outcome Test. Patients underwent psychophysical olfactory testing, olfactory cleft examination, and computed tomography (CT) scans. Results: Sixteen anosmic patients were included. The mean Sniffin' Sticks score was 4.6 ± 1.7. The majority of patients had no endoscopical abnormality, with a mean olfactory cleft endoscopy score of 0.6 ± 0.9. The olfactory clefts were opacified in three patients on the CT scan. The mean radiological olfactory cleft score was 0.7 ± 0.8. There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. Conclusions: The olfactory cleft of anosmic COVID-19 patients is free regarding endoscopic examination and imaging. The anosmia etiology is not related to edema of the olfactory cleft. Level of Evidence: 4 Laryngoscope, 2020., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

61. ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review

Author

Lechien, Jérôme, Radulesco, Thomas, Calvo-Henriquez, Christian, Chiesa-Estomba, Carlos Miguel, Hans, Stéphane, Barillari, Maria Rosaria, Cammaroto, Giovanni, Descamps, Géraldine, Hsieh, Julien, Vaira, Luigi, De Riu, Giacomo, Sowerby, Leigh, Gengler, Isabelle, Michel, Justin, Saussez, Sven, Lechien, Jérôme, Radulesco, Thomas, Calvo-Henriquez, Christian, Chiesa-Estomba, Carlos Miguel, Hans, Stéphane, Barillari, Maria Rosaria, Cammaroto, Giovanni, Descamps, Géraldine, Hsieh, Julien, Vaira, Luigi, De Riu, Giacomo, Sowerby, Leigh, Gengler, Isabelle, Michel, Justin, and Saussez, Sven

Abstract

To review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue. Scopus, Cochrane Library, Medrxiv, Google Scholar and PubMED/MEDLINE were searched by four independent investigators for studies investigating ACE2 or TMPRSS2 expressions in head and neck tissues. The following outcomes were considered: sample origin (animal versus human); detection method; anatomical location and cell types. PRISMA checklist and modified population, intervention, comparison, outcome, timing and setting (PICOTS) framework were used to perform the review. Of the 24 identified studies, 17 met our inclusion criteria. Thirteen studies were conducted during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. ACE2 and TMPRSS2 were expressed in oral, pharyngeal, sinusonasal human mucosa. The following cell types expressed ACE2: basal, apical, goblet, minor salivary, and endothelial cells. TMPRSS2 was found in goblet and apical respiratory cells. ACE2 and TMPRSS2 were found in the olfactory region, especially in sustentacular non-neural and neural stem cells. Animal studies suggested that ACE2 expression may vary regarding age. There was an important heterogeneity between studies in the methods used to detect ACE2 and TMPRSS2, leading to a potential identification bias. The SARS-CoV-2 receptors, ACE2 and TMPRSS2, are both expressed in many head and neck tissues, enabling the viral entry into the host organism., SCOPUS: re.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

62. Patterns of smell recovery in 751 patients affected by the COVID-19 outbreak

Author

Chiesa-Estomba, Carlos Miguel, Lechien, Jérôme, Radulesco, Thomas, Michel, Justin, Sowerby, Leigh, Hopkins, Claire, Saussez, Sven, Chiesa-Estomba, Carlos Miguel, Lechien, Jérôme, Radulesco, Thomas, Michel, Justin, Sowerby, Leigh, Hopkins, Claire, and Saussez, Sven

Abstract

Background and purpose: Post-viral olfactory dysfunction is well established and has been shown to be a key symptom of COVID-19 with more than 66% of European and US patients reporting some degree of loss of smell. Persistent olfactory dysfunction appears to be commonplace and will drive the demand for general practitioner, otolaryngology or neurology consultation in the next few months – evidence regarding recovery will be essential in counselling our patients. Methods: This was a prospective survey-based data collection and telemedicine follow-up. Results: In total, 751 patients completed the study, of whom 477 were females and 274 males. The mean age of the patients was 41 ± 13 years (range 18–60). There were 621 patients (83%) who subjectively reported a total loss of smell and 130 (17%) a partial loss. After a mean follow-up of 47 ± 7 days (range 30–71) from the first consultation, 277 (37%) patients still reported a persistent subjective loss of smell, 107 (14%) reported partial recovery and 367 (49%) reported complete recovery. The mean duration of the olfactory dysfunction was 10 ± 6 days (range 3–31) in those patients who completely recovered and 12 ± 8 days (range 7–35) in those patients who partially recovered. Conclusions: According to our results, at this relatively early point in the pandemic, subjective patterns of recovery of olfactory dysfunction in COVID-19 patients are valuable for our patients, for hypothesis generation and for treatment development., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

64. SCAR-Q--French Version

Author

Radulesco, Thomas, primary, Mancini, Julien, additional, Penicaud, Martin, additional, Grob, Jean‑Jacques, additional, Richard, Marie‑Aleth, additional, Dessi, Patrick, additional, Malissen, Nausicaa, additional, and Michel, Justin, additional

Published
2021
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65. Role of Tonsillectomy in the Management of Carcinomas of Unknown Primary of the Head and Neck: A Retrospective Study Based on p16 Analysis

Author

Podeur, Pauline, primary, Mancini, Julien, additional, Delgrande, Jean, additional, Santini, Laure, additional, Salas, Sébastien, additional, Wong, Stéphanie, additional, Giovanni, Antoine, additional, Dessi, Patrick, additional, Michel, Justin, additional, Radulesco, Thomas, additional, and Fakhry, Nicolas, additional

Published
2020
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66. An Uncommon Sinonasal Metastasis

Author

Mimari, Clémence, primary, Penicaud, Martin, additional, Taieb, David, additional, Dessi, Patrick, additional, Michel, Justin, additional, and Radulesco, Thomas, additional

Published
2020
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67. Olfactory and gustative disorders for the diagnosis of COVID-19

Author

Boudjema, Sophia, primary, Finance, Julie, additional, Coulibaly, Fatoumata, additional, Meddeb, Line, additional, Tissot-Dupont, Hervé, additional, Michel, Moïse, additional, Lagier, Jean Christophe, additional, Million, Matthieu, additional, Radulesco, Thomas, additional, Michel, Justin, additional, Brouqui, Philippe, additional, Raoult, Didier, additional, Fenollar, Florence, additional, and Parola, Philippe, additional

Published
2020
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69. ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review

Author

Lechien, Jerome R., primary, Radulesco, Thomas, additional, Calvo-Henriquez, Christian, additional, Chiesa-Estomba, Carlos M., additional, Hans, Stéphane, additional, Barillari, Maria R., additional, Cammaroto, Giovanni, additional, Descamps, Géraldine, additional, Hsieh, Julien, additional, Vaira, Luigi, additional, De Riu, Giacomo, additional, Sowerby, Leigh, additional, Gengler, Isabelle, additional, Michel, Justin, additional, and Saussez, Sven, additional

Published
2020
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71. Correction to: Sinus and anterior skull base surgery during the COVID-19 pandemic: systematic review, synthesis and YO-IFOS position

Author

Radulesco, Thomas, primary, Lechien, Jerome R., additional, Sowerby, Leigh J., additional, Saussez, Sven, additional, Chiesa-Estomba, Carlos, additional, Sargi, Zoukaa, additional, Lavigne, Philippe, additional, Calvo-Henriquez, Christian, additional, Lim, Chwee Ming, additional, Tangjaturonrasme, Napadon, additional, Vatanasapt, Patravoot, additional, Dehgani-Mobaraki, Puya, additional, Fakhry, Nicolas, additional, Ayad, Tareck, additional, and Michel, Justin, additional

Published
2020
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72. Sinus and anterior skull base surgery during the COVID-19 pandemic: systematic review, synthesis and YO-IFOS position

Author

Radulesco, Thomas, primary, Lechien, Jerome R., additional, Sowerby, Leigh J., additional, Saussez, Sven, additional, Chiesa-Estomba, Carlos, additional, Sargi, Zoukaa, additional, Lavigne, Philippe, additional, Calvo-Henriquez, Christian, additional, Lim, Chwee Ming, additional, Tangjaturonrasme, Napadon, additional, Vatanasapt, Patravoot, additional, Dehgani-Mobaraki, Puya, additional, Fakhry, Nicolas, additional, Ayad, Tareck, additional, and Michel, Justin, additional

Published
2020
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74. Management of cN0 low‐grade mucoepidermoid carcinomas of salivary glands: Prospective multicentre study of 152 cases of the French Network of Rare Head and Neck Tumors (REFCOR)

Author

Saloner Dahan, Laurie, primary, Giorgi, Roch, additional, Garrel, Renaud, additional, Le Taillandier de Gabory, Ludovic, additional, Costes‐Martineau, Valérie, additional, Herman, Philippe, additional, Poissonnet, Gilles, additional, Mauvais, Olivier, additional, Malard, Olivier, additional, Vergez, Sébastien, additional, Uro‐Coste, Emmanuelle, additional, Barry, Béatrix, additional, Bach, Christine, additional, Chevalier, Dominique, additional, Mouawad, Francois, additional, Merol, Jean‐Claude, additional, Bastit, Vianney, additional, Thariat, Juliette, additional, Gilain, Laurent, additional, Dufour, Xavier, additional, Righini, Christian‐Adrien, additional, Dessi, Patrick, additional, Michel, Justin, additional, Radulesco, Thomas, additional, Even, Caroline, additional, Baujat, Bertrand, additional, and Fakhry, Nicolas, additional

Published
2020
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78. Computational fluid dynamics and septal deviations—Virtual surgery can predict post‐surgery results: A preliminary study including two patients

Author

Meister, Lionel, Bouchet, Gilles, Varoquaux, Arthur, Giordano, Jérome, Dessi, Patrick, Perrier, Pierre, Michel, Justin, Thomas, Radulesco, Lionel, Meister, Gilles, Bouchet, Jérome, Giordano, Patrick, Dessi, Pierre, Perrier, Justin, Michel, Radulesco, Thomas, Institut universitaire des systèmes thermiques industriels (IUSTI), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
medicine.medical_specialty, Pilot Projects, Post surgery, Computational fluid dynamics, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 03 medical and health sciences, 0302 clinical medicine, medicine, Nasal septum, Humans, Computer Simulation, Nasal Airway Obstruction, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], 030223 otorhinolaryngology, Nasal Septum, business.industry, fungi, Virtual Reality, food and beverages, nasal airway obstruction, Prognosis, Rhinoplasty, Surgery, Unsteady flow, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Hydrodynamics, Nasal Cavity, Nasal Obstruction, business, CFD, virtual surgery, unsteady flow
Abstract

International audience; Computational fluid dynamics and septal deviations-Virtual surgery can predict post-surgery results: A preliminary study including two patients

Published
2019
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87. French validation of the FACE‐Q Rhinoplasty module.

Author

Radulesco, Thomas, Penicaud, Martin, Santini, Laure, Graziani, Jade, Dessi, Patrick, and Michel, Justin

Subjects
*RHINOPLASTY, *PLASTIC surgery
Abstract

Objectives: The aim of this study was to translate the FACE‐Q "Rhinoplasty" module into French and validate its use for the French‐speaking population. Design: "Satisfaction with the nose" and "Satisfaction with nostrils" questionnaires were used and translated. Settings: We were granted permission to use the FACE‐Q rhinoplasty module by the development team. These two questionnaires constitute the rhinoplasty module of the FACE‐Q questionnaire. ISPOR and WHO recommendations were used to complete the translation process from English into French in six steps. Main outcome measurement: Our goal was to obtain, not a literal translation, but rather a translation of the idea or concept. Results: Each step allowed us to make changes to achieve a conceptual translation equivalent to the original version. Conclusion: The FACE‐Q questionnaire is a reference in the field of cosmetic surgery outcome evaluation. The use of two validated translation recommendations, with a six‐step translation‐back translation process, leads to a French version corresponding to the original. This version is usable in a French‐speaking population. [ABSTRACT FROM AUTHOR]

Published
2019
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88. New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients.

Author

Vatin, Loraine, Vitte, Joanna, Radulesco, Thomas, Morvan, Jean‐Baptiste, Del Grande, Jean, Varoquaux, Arthur, Ranque, Stéphane, Gaudart, Jean, Dessi, Patrick, Cassagne, Carole, and Michel, Justin

Subjects
PARANASAL sinuses, ALLERGIC fungal sinusitis
Abstract

The article prospective study that investigates the tools used in the preoperative diagnosis of patients suffering from allergic fungal sinusitis in Marseille, France.

Published
2019
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89. Past, Present, and Future Diagnostic Methods for the Early Noninvasive Detection of Oral Premalignant Lesions: A State of the Art and Systematic Review

Author

Khong, Brendan, Ferlito, Salvatore, Quek, Stuart, Conte, Gianluca, Ingrassia, Angelo, Lechien, Jerome Rene, Chiesa-Estomba, Carlos, Mayo, Miguel, Maniaci, Antonino, Radulesco, Thomas, Michel, Justin, Fakhry, Nicolas, and Polosa, Riccardo

Abstract

Objectives:To provide an in-depth analysis of noninvasive methods for the early diagnosis of oral premalignant lesions, focusing on novel biomarkers and optical technologies, and to discuss their potential in improving the prognosis of patients with oral oncological diseases. Methods:This state-of-the-art review examines various noninvasive diagnostic techniques, including the utilization of salivary microRNAs and optical technologies such as Raman spectroscopy, elastic scattering spectroscopy, diffuse reflectance spectroscopy, narrow-band imaging, autofluorescence imaging, toluidine blue staining, and microendoscopy. Results:Several noninvasive techniques have shown varying degrees of effectiveness in detecting oral cancer. Autofluorescence imaging exhibited sensitivities up to 100% but had variable specificity. toluidine blue staining reported sensitivity between 77% and 100% for high-risk lesions or cancer, with specificity around 45% to 67%. Spectroscopy techniques achieved 72% to 100% sensitivities and specificities of 75% to 98%. Microendoscopy presented a sensitivity of 84% to 95% and a specificity of 91% to 95%. Conclusion:The review highlights the strengths and limitations of each noninvasive diagnostic method and their recent advancements. Although promising results have been demonstrated, there is a need for further development of reliable strategies for early detection and intervention in oral oncology.

Published
2024
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90. The Impact of the Post-Traumatic Facial Reconstruction on Postoperative Weight Loss

Author

Gengler, Isabelle, Min, Susie, Jiang, Megan, Zhang, Grace, Altaye, Mekibib, Radulesco, Thomas, Lechien, Jerome R., and Hsieh, Tsung-Yen

Abstract

Objectives:To identify risk factors and evaluate the impact of various facial fractures and reconstruction surgeries on postoperative weight change. Methods:Retrospective, monocentric study was performed at a tertiary care center. Medical history, type and mechanism of fracture, operative factors, and postoperative weights at follow-up appointments for 145 adult patients undergoing surgical repair for maxillofacial fractures were collected. Further information was obtained on postoperative diet and whether patients received maxillomandibular fixation (MMF). Univariate and multivariate analyses were utilized to evaluate effects of surgical reconstruction after facial trauma on postoperative weight loss. Results:Patients lost 3.2 ± 4.9 kg (95% confidence interval = 2.7-4.1, P< .0001) on average, with maximum loss between date of surgery and first follow-up. Univariate analysis demonstrated that intensive care unit admission (5.9 kg, SD 5.4, P= .001), nasogastric tube placement (5.1 kg, SD 4.6, P= .012), and MMF (4.4 kg, SD 5.4, P< .0001) were associated with more severe weight loss. Multivariate analyses showed that only MMF remained a significant risk factor for increased weight loss (avg. 6.0, standard error 1.93, tvalue 3.11, P= .0024). Conclusions:We report significant weight loss following facial trauma and reconstruction, which emphasizes the need to perform further studies on nutrition protocols for this patient population to optimize wound healing.

Published
2024
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91. Sex Estimation from Human Cranium: Forensic and Anthropological Interest of Maxillary Sinus Volumes.

Author

Radulesco, Thomas, Michel, Justin, Mancini, Julien, Dessi, Patrick, and Adalian, Pascal

Subjects
*FORENSIC sciences, *MAXILLARY sinus, *INTRACLASS correlation, *SEXUAL dimorphism, *FORENSIC medicine
Abstract

Abstract: Sex estimation is a key objective of forensic science. We aimed to establish whether maxillary sinus volumes (MSV) could assist in estimating an individual's sex. One hundred and three CT scans were included. MSV were determined using three‐dimensional reconstructions. Two observers performed three‐dimensional MSV reconstructions using the same methods. Intra‐ and interobserver reproducibility were statistically compared using the intraclass correlation coefficient (ICC) (α = 5%). Both intra‐ and interobserver reproducibility were perfect regarding MSV; both ICCs were 100%. There were no significant differences between right and left MSV (p = 0.083). No correlation was found between age and MSV (p > 0.05). We demonstrated the existence of sexual dimorphism in MSV (p < 0.001) and showed that MSV measurements gave a 68% rate of correct allocations to sex group. MSV measurements could be useful to support sex estimation in forensic medicine. [ABSTRACT FROM AUTHOR]

Published
2018
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92. Rédiger dans les European Annals of Otorhinolaryngology Head & Neck Diseases. Faites et ne Faites pas!

Author

Righini, Christian, Laccourreye, Ollivier, Fakhry, Nicolas, Vidal, Valérie Franco, Leboulanger, Nicolas, Lisan, Quentin, Radulesco, Thomas, Rumeau, Cécile, Schmerber, Sébastien, Simon, François, Van, Hung Thaï, Vergez, Sébastien, Vincent, Christophe, and Jankowski, Roger

Abstract

Trop d’articles sont encore refusés dans les revues médicales scientifiques, en raison du manque de préparation du manuscrit et de la méconnaissance des règles rédactionnelles modernes qui régissent la rédaction médicale scientifique. Aussi le comité de rédaction des European Annals of Otorhinolaryngology Heads & Neck Diseasesa synthétisé les travaux publiés par ses membres depuis 2020 dans les colonnes de la revue scientifique de la société française d’otorhinolaryngologie et de la société internationale francophone d’otorhinolaryngologie ainsi que les données de la littérature indexée PubMed dédiées à la rédaction médicale scientifique en otorhinolaryngologie au XXIèmesiècle. Avec cette mise au point construite sur le mode « Faites !» et « Ne Faites Pas !», les auteurs espèrent fournir aux auteurs un guide pratique facilitant la publication de travaux scientifiques rigoureux, reproductibles et transparents, en accord avec l’évolution pour une meilleure science souhaitée par la société depuis le début de ce siècle.

Published
2023
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93. Differential Nasal Recolonization and Microbial Profiles in Chronic Rhinosinusitis With Nasal Polyps Patients After Endoscopic Sinus Surgery or Dupilumab Treatment: A Prospective Observational Study.

Author

Maniaci, Antonino, Vertillo Aluisio, Gaia, Stefani, Stefania, Cocuzza, Salvatore, Lechien, Jerome Rene, Radulesco, Thomas, Michel, Justin, Santagati, Maria, and La Mantia, Ignazio

Subjects
*STAPHYLOCOCCUS epidermidis, *NASAL polyps, *POLYMERASE chain reaction, *NASAL cavity, *MICROBIAL cultures, *ENDOSCOPIC surgery
Abstract

ABSTRACT Introduction Methods Results Conclusion The role of microbial profiles in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) pathogenesis is increasingly recognised, with microbial imbalances perpetuating inflammation. We performed this study to associate the different nasal microbiological profile changes with the response to surgical or monoclonal treatment.This prospective observational study evaluated changes in the nasal microbial profiles of 44 patients (22 dupilumab, 22 surgery) over 6 months. Clinical assessments were performed at baseline and follow‐ups, including Sino‐Nasal Outcome Test‐22 (SNOT‐22) scores and Sniffin Sticks‐Identification (SS‐I) olfactory testing. Microbial profiling of nasal swabs was carried out by microbial culture and subsequent molecular identification by Polymerase chain reaction (PCR) and sequencing.Baseline characteristics of 44 patients (22 dupilumab, 22 surgery) enrolled in this study were similar between groups. In the dupilumab group, Staphylococcus epidermidis prevalence rose from 37.03% to 59.25%, while Pseudomonas aeruginosa was eradicated. Moreover, dupilumab stabilised Staphylococcus aureus at 63.64%, while its prevalence increased in the surgery group (from 22.72% to 50%). When bacterial groups were associated with clinical scores, P. aeruginosa carriers had worse SNOT‐22 (21.00 ± 1.41) and SS‐I (5.50 ± 0.71) scores. Instead, S. epidermidis‐colonised patients exhibited significantly lower mean SNOT‐22 (15.39 ± 8.54) and greater SS‐I scores (8.39 ± 3.77). The best outcomes were found in the subgroup of S. epidermidis carriers undergoing the dupilumab treatment.The two treatments modulated the microbial profiles differently, and, most importantly, clinical responses might depend on the association between treatment and the dominant bacterial species colonising the nasal cavity. Further investigation into microbial‐restorative strategies could enhance outcomes for better treatment of CRS. [ABSTRACT FROM AUTHOR]

Published
2024
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94. Sound-induced drug distribution in the cochlea, how close are we? A PRISMA scoping review.

Author

Gargula, Stéphane, Ebode, Dario, Meister, Lionel, Radulesco, Thomas, and Michel, Justin

Subjects
*VESTIBULAR stimulation, *VESTIBULAR apparatus, *ACOUSTIC stimulation, *FLUID dynamics, *COCHLEA
Abstract

AbstractObjectiveDesignStudy SampleResultsConclusionsTo evaluate the efficacy of sound stimulation for enhancing drug distribution in the cochlea’s perilymph, crucial for treating one of the most inaccessible organs and a major disability factor worldwide.A systematic scoping review following PRISMA guidelines was conducted, analysing studies on cochlear fluid dynamics influenced by sound stimulation. Data were collected from PubMed and Google Scholar using both MeSH and non-MeSH terms, with exclusions for unrelated topics.Thirteen studies met the inclusion criteria, providing insights into the mechanics of cochlear perilymphatic flow and its potential enhancement through sound stimulation.The review highlights two primary mechanisms capable of inducing significant perilymphatic flow from the base towards the apex: complex audible sound stimulation creating a "streaming channel" and low-frequency stimulation at high intensity. Despite the theoretical potential, the clinical applicability of these techniques remains unproven, and the safety of low-frequency, high-intensity stimulation for the cochlea and vestibular system should be demonstrated.Sound stimulation appears to be a viable method for inducing perilymphatic movements, potentially improving drug delivery to remote cochlear regions. Future research should focus on the clinical safety and efficacy of these stimulations to fully utilise this approach in therapeutic applications. [ABSTRACT FROM AUTHOR]

Published
2024
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95. Skin and Nasal Involvement: Look for Sarcoidosis!

Author

Dessi, Patrick, Radulesco, Thomas, Michel, Justin, Jarrot, Pierre-André, Cauchois, Raphael, Kaplanski, Gilles, and Macagno, Nicolas

Subjects
*SARCOIDOSIS, *SINUSITIS, *SKIN diseases, *NASAL mucosa, *ENDOSCOPY, *NASAL cavity, *DISEASES, *SARCOIDOSIS diagnosis, *BIOPSY, *DIFFERENTIAL diagnosis, *NOSE, *SKIN
Published
2018
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97. Assessment of Sleep Features, Mental Health Outcomes, and Alcohol and Tobacco Consumption in Residents and Fellows in Otolaryngology Before and During the COVID-19 Pandemic.

Author

Chebib E, Chiesa-Estomba CM, Radulesco T, Barillari MR, Mayo-Yáñez M, Hans S, and Lechien JR

Subjects
Cohort Studies, Depression epidemiology, Humans, Outcome Assessment, Health Care, Pandemics, Sleep, Tobacco Use, COVID-19 epidemiology, Otolaryngology, Sleep Initiation and Maintenance Disorders epidemiology
Abstract

Importance: The workload of many residents and fellows in otolaryngology-head and neck surgery has particularly increased during the COVID-19 pandemic; however, outcomes associated with mental health status and sleep remain unclear., Objective: To assess the sleep, mental status, and alcohol and tobacco consumption habits of residents and fellows before the COVID-19 pandemic (before March 10, 2020) and during the pandemic period (after March 10, 2020)., Design, Setting, and Participants: This cohort study included residents and fellows of 6 university hospitals of European regions with a high prevalence of COVID-19 cases. Survey development, data collection, and analyses were performed from March 10, 2020, to June 30, 2021., Main Outcomes and Measures: Residents and fellows were invited to respond to a survey assessing management of treatment in patients with COVID-19 and related work features; stress and mental health status (Beck Depression Inventory); sleep features (Insomnia Severity Index); and alcohol and tobacco consumption., Results: Of 220 potential participants, 128 residents and fellows (58.2%) completed the evaluations. No demographic data on mean (SD) age and sex or gender were collected. The prepandemic mean (SD) score of the Beck Depression Inventory (3.1 [2.8]) significantly increased after the start of the pandemic (mean [SD] score, 4.2 [4.1]; difference, -1.1; 95% CI, -1.96 to -0.24; d = 0.31), and the prepandemic mean (SD) score of the Insomnia Severity Index (4.9 [4.1) significantly increased after the start of the pandemic (mean [SD] score, 6.0 [4.9]; difference, 1.1; 95% CI, 0.00-2.2; d = 0.25). Insomnia concerned 46% of participants (51 of 112), and depression concerned 47% of participants (55 of 116) during the pandemic. The mean (SD) prepandemic alcohol consumption (1.7 [2.3] IU per week) significantly increased after the start of the pandemic (mean [SD], 2.9 [4.0] IU per week; difference, 1.2; 95% CI, 0.40-2.00; d = 0.37). Residents and fellows who were mobilized in COVID-19 units reported significant increases of workload (r = 0.2; 95% CI, 0.1-0.3), stress level (r = 0.2; 95% CI, 0.1-0.3), and alcohol consumption (for 5-10 IU per week: mean [SD] prepandemic, 11 [8] IU per week vs postpandemic, 20 [16] IU per week; d = 0.37) and a worsening of sleep status (for moderate insomnia: mean [SD] prepandemic Insomnia Severity Index, 4 [3] vs postpandemic, 15 [12]; d = 0.25). There was a significant association between alcohol consumption and the Beck Depression Inventory score (r = 0.4; 95% CI, 0.2-0.6). The mean (SD) consumption of tobacco decreased from 2.1 (1.3) to 0.9 (1.5) (difference, -1.20; 95% CI, -1.50 to -0.85; d = 0.85)., Conclusions and Relevance: Results of this cohort study suggest that the workload of residents and fellows increased during the pandemic, which may be associated with a worsening of mental health and sleep status and an increase of alcohol consumption.

Published
2022
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100. An Uncommon Sinonasal Metastasis.

Author

Mimari C, Penicaud M, Taieb D, Dessi P, Michel J, and Radulesco T

Subjects
Adult, Carcinoma therapy, Female, Humans, Paranasal Sinus Neoplasms therapy, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms therapy, Carcinoma diagnosis, Carcinoma secondary, Paranasal Sinus Neoplasms diagnosis, Paranasal Sinus Neoplasms secondary, Thyroid Neoplasms pathology
Published
2020
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