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867 results on '"Raimondi L."'

55. Astonishing response to Cetuximab in metastatic nasopharyngeal carcinoma: a case report.

Author

Raimondi, L., Rossi, L., Cimino, G., and Gozzi, E.

Subjects
CETUXIMAB, NASOPHARYNX cancer, EPIDERMAL growth factor, METASTASIS, PREVENTIVE medicine
Abstract

Nasopharyngeal carcinoma, one of the most common head and neck cancers in Southeast Asia, is uncommon in Western countries and it is frequently diagnosed in advanced stage. Chemotherapy given with radiation therapy, followed by more chemotherapy, is the standard of care of stage IV nasopharyngeal carcinoma but Cetuximab, an epidermal growth factor (EGFR) inhibitor, is now making its way in the treatment of locoregionally advanced nasopharyngeal carcinoma. We report a case of 58 years old patient with metastatic nasopharyngeal carcinoma with an astonishing response to Cetuximab. At the time of writing, the patient is still in treatment with Cetuximab with excellent disease control. [ABSTRACT FROM AUTHOR]

Published
2021
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58. Nanoscale transient gratings excited and probed by extreme ultraviolet femtosecond pulses

Author

Bencivenga, F., primary, Mincigrucci, R., additional, Capotondi, F., additional, Foglia, L., additional, Naumenko, D., additional, Maznev, A. A., additional, Pedersoli, E., additional, Simoncig, A., additional, Caporaletti, F., additional, Chiloyan, V., additional, Cucini, R., additional, Dallari, F., additional, Duncan, R. A., additional, Frazer, T. D., additional, Gaio, G., additional, Gessini, A., additional, Giannessi, L., additional, Huberman, S., additional, Kapteyn, H., additional, Knobloch, J., additional, Kurdi, G., additional, Mahne, N., additional, Manfredda, M., additional, Martinelli, A., additional, Murnane, M., additional, Principi, E., additional, Raimondi, L., additional, Spampinati, S., additional, Spezzani, C., additional, Trovò, M., additional, Zangrando, M., additional, Chen, G., additional, Monaco, G., additional, Nelson, K. A., additional, and Masciovecchio, C., additional

Published
2019
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62. Risk management and Healthcare responsibility. How to guarantee legal protection in Medicine.

Author

Guerra, F., Guzzo, A. S., La Rosa, P., Miatto, I., Vergati, D., Miredi, F., Gasparrini, N., Raimondi, L., Corridore, D., Nardi, G. M., Mazur, M., la Torre, G., and Ottolenghi, L.

Subjects
MEDICAL care, PUBLIC safety, MEDICAL personnel, IMMUNOHISTOCHEMISTRY, BIOENGINEERING
Abstract

Having regard to the increasing attention to the issue of safety and health of patients and workers by low, the hypothesis that this topic will be the growing trend in the next years does not seem to be manifestly unfounded. For this reason, it is wise for healthcare professionals to already be aware that any violation of the interests underlying the legislation in question entails a ruling on civil and/or criminal liability. It is therefore necessary to identify the most suitable means to prevent undue harm occurring, partly to exempt healthcare professionals and hospitals from compensation costs, thereby providing them with recourse to insurance coverage. Healthcare facility organisations must adopt Risk Management techniques as a tool to simultaneously guarantee the effectiveness of health services (in this case), the efficiency of the management economy, and finally compliance with all legally required precautions. This will relegate the occurrence of an adverse event to remote and unpredictable hypotheses, thus guaranteeing useful recourse to insurance coverage to compensate any harm that does occur. [ABSTRACT FROM AUTHOR]

Published
2021
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66. An approach for realizing four-wave-mixing experiments stimulated by two-color extreme ultraviolet pulses

Author

Bleiner, Davide, Bencivenga, F., Mincigrucci, R., Capotondi, F., Calvi, A., Cucini, R., Foglia, L., Pedersoli, E., Principi, E., Simoncig, A., Cinquegrana, P., Danailov, M. B., De Ninno, G., Di Mitri, S., Gaio, G., Gessini, A., Giannessi, L., Mahne, N., Manfredda, M., Nikolov, I. P., Penco, G. M., Raimondi, L., Ribič, P. R., Svetina, C., Trovò, M., Zangrando, M., and Masciovecchio, C.

Published
2021
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68. The FERMI free-electron lasers

Author

Allaria E., Badano L., Bassanese S., Capotondi F., Castronovo D., Cinquegrana P., Danailov M.B., D'Auria G., Demidovich A., De Monte R., De Ninno G., Di Mitri S., Diviacco B., Fawley W.M., Ferianis M., Ferrari E., Gaio G., Gauthier D., Giannessi L., Iazzourene F., Kurdi G., Mahne N., Nikolov I., Parmigiani F., Penco G., Raimondi L., Rebernik P., Rossi F., Roussel E., Scafuri C., Serpico C., Sigalotti P., Spezzani C., Svandrlik M., Svetina C., Trovo M., Veronese M., Zangrando D., Zangrando M., Giannessi, L., Allaria, E, Badano, L., Bassanese, S., Capotondi, Flavio, Castronovo, D., Cinquegrana, Paolo, Danailov, M. B., D'Auria, G., Demidovich, A., De Monte, R., DE NINNO, Giovanni, DI MITRI, Simone, Diviacco, Bruno, Fawley, W. M., Ferianis, M., Ferrari, Eugenio, Gaio, G., Gauthier, D., Iazzourene, F., Kurdi, G., Mahne, N., Nikolov, I., Parmigiani, Fulvio, Penco, G., Raimondi, L., Rebernik, P., Rossi, F., Roussel, E., Scafuri, C., Serpico, Claudio, Sigalotti, P., Spezzani, C., Svandrlik, M., Svetina, Cristian, Trovò, Mauro, Veronese, M., Zangrando, D., and Zangrando, M.

Subjects
Nuclear and High Energy Physics, Extreme ultraviolet lithography, 02 engineering and technology, Radiation, 01 natural sciences, law.invention, Optics, free-electron laser, law, 0103 physical sciences, 010306 general physics, coherence Special issue on X-ray Free-Electron Laser, Instrumentation, Nuclear and High Energy Physic, Physics, coherence Special issue on X-ray Free-Electron Lasers, lasers, free-electron lasers, business.industry, Wavelength range, Free-electron laser, 021001 nanoscience & nanotechnology, Laser, laser, Extreme ultraviolet, Optoelectronics, 0210 nano-technology, business, Coherence (physics), Fermi Gamma-ray Space Telescope
Abstract

FERMI is a seeded free-electron laser (FEL) facility located at the Elettra laboratory in Trieste, Italy, and is now in user operation with its first FEL line, FEL-1, covering the wavelength range between 100 and 20 nm. The second FEL line, FEL-2, a high-gain harmonic generation double-stage cascade covering the wavelength range 20–4 nm, has also completed commissioning and the first user call has been recently opened. An overview of the typical operating modes of the facility is presented.

Published
2015

70. First Evidence of Purely Extreme-Ultraviolet Four-Wave Mixing

Author

Foglia, L., primary, Capotondi, F., additional, Mincigrucci, R., additional, Naumenko, D., additional, Pedersoli, E., additional, Simoncig, A., additional, Kurdi, G., additional, Calvi, A., additional, Manfredda, M., additional, Raimondi, L., additional, Mahne, N., additional, Zangrando, M., additional, Masciovecchio, C., additional, and Bencivenga, F., additional

Published
2018
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74. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro

Author

Marvaso G, Barone A, Amodio N, Raimondi L, Agosti V, Altomare E, Scotti V, Lombardi A, Bianco R, Bianco C, Tassone P, Tagliaferri P., CARAGLIA, Michele, Marvaso, G, Barone, A, Amodio, N, Raimondi, L, Agosti, V, Altomare, E, Scotti, V, Lombardi, A, Bianco, R, Bianco, C, Caraglia, Michele, Tassone, P, and Tagliaferri, P.

Abstract

Radiotherapy is one of the most therapeutic strategies for breast cancer patients, although its efficacy may be reduced by intrinsic radiation resistance of cancer cells. Recent investigations demonstrate a link between cancer cell radio-resistance and activation of sphingosine kinase (SphK1), which plays a key role in the balance of lipid signaling molecules. Sphingosine kinase (SphK1) activity can alter the sphingosine-1-phosphate (S1P)/ceramide ratio leading to an imbalance in the sphingolipid rheostat. Fingolimod (FTY720) is a novel sphingosine analog and a potent immunosuppressive drug that acts as a SphK1 antagonist, inhibits the growth, and induces apoptosis in different human cancer cell lines. We sought to investigate the in vitro radiosensitizing effects of FTY720 on the MDA-MB-361 breast cancer cell line and to assess the effects elicited by radiation and FTY720 combined treatments. We found that FTY720 significantly increased anti-proliferative and pro-apoptotic effects induced by a single dose of ionizing radiation while causing autophagosome accumulation. At the molecular level, FTY720 significantly potentiated radiation effects on perturbation of signaling pathways involved in regulation of cell cycle and apoptosis, such as PI3K/AKT and MAPK. In conclusion, our data highlight a potent radiosensitizing effect of FTY720 on breast cancer cells and provide the basis of novel therapeutic strategies for breast cancer treatment.

Published
2014

75. A p53-Dependent Tumor Suppressor Network Is Induced by Selective miR-125a-5p Inhibition in Multiple Myeloma Cells

Author

Leotta M., Biamonte L., Raimondi L., Ronchetti D., Di Martino M. T., Botta C., Leone E., Pitari M. R., Neri A., Giordano A., Tagliaferri P., Tassone P., Amodio N., Leotta M., Biamonte L., Raimondi L., Ronchetti D., Di Martino M.T., Botta C., Leone E., Pitari M.R., Neri A., Giordano A., Tagliaferri P., Tassone P., and Amodio N.

Subjects
miR-125a, p53, microRNA, multiple,myeloma
Abstract

The analysis of deregulated microRNAs (miRNAs) is emerging as a novel approach to disclose the regulation of tumor suppressor or tumor promoting pathways in tumor cells. Targeting aberrantly expressed miRNAs is therefore a promising strategy for cancer treatment. By miRNA profiling of primary plasma cells from multiple myeloma (MM) patients, we previously reported increased miR-125a-5p levels associated to specific molecular subgroups. On these premises, we aimed at investigating the biological effects triggered by miR-125a-5p modulation in MM cells. Expression of p53 pathway-related genes was down-regulated in MM cells transfected with miR-125a-5p mimics. Luciferase reporter assays confirmed specific p53 targeting at 3′UTR level by miR-125a-5p mimics. Interestingly, bone marrow stromal cells (BMSCs) affected the miR-125a-5p/p53 axis, since adhesion of MM cells to BMSCs strongly up-regulated miR-125a-5p levels, while reduced p53 expression. Moreover, ectopic miR-125a-5p reduced, while miR-125-5p inhibitors promoted, the expression of tumor suppressor miR-192 and miR-194, transcriptionally regulated by p53. Lentiviral-mediated stable inhibition of miR-125a-5p expression in wild-type p53 MM cells dampened cell growth, increased apoptosis and reduced cell migration. Importantly, inhibition of in vitro MM cell proliferation and migration was also achieved by synthetic miR-125a-5p inhibitors and was potentiated by the co-expression of miR-192 or miR-194. Taken together, our data indicate that miR-125a-5p antagonism results in the activation of p53 pathway in MM cells, underlying the crucial role of this miRNA in the biopathology of MM and providing the molecular rationale for the combinatory use of miR-125a inhibitors and miR-192 or miR-194 mimics for MM treatment. J. Cell. Physiol. 229: 2106-2116, 2014. © 2014 Wiley Periodicals, Inc.

Published
2014

76. Magnetization and Microstructure Dynamics in Fe/MnAs/GaAs(001): Fe Magnetization Reversal by a Femtosecond Laser Pulse

Author

Spezzani , C., Ferrari , E., Allaria , E., Vidal , Franck, Ciavardini , A., Delaunay , R., Capotondi , F., Pedersoli , E., Coreno , M., Svetina , C., Raimondi , L., Zangrando , M., Ivanov , R., Nikolov , I., Demidovich , A., Danailov , M. B., Popescu , H., Eddrief , Mahmoud, De Ninno , G., Kiskinova , M., Sacchi , Maurizio, Institut des Nanosciences de Paris (INSP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), CNRS, via the PEPS_SASLELX program, Italian-Slovenian Crossborder Cooperation Programme (CITIUS) [2013/2010090600115298], MIUR [FIRB-RBAP045JF2, FIRB-RBAP06AWK3], Spezzani, C, Ferrari, Eugenio, Allaria, E., Vidal, F., Ciavardini, A., Delaunay, R., Capotondi, Flavio, Pedersoli, E., Coreno, M., Svetina, Cristian, Raimondi, L., Zangrando, M., Ivanov, R., Nikolov, I., Demidovich, A., Danailov, M. B., Popescu, H., Eddrief, M., DE NINNO, Giovanni, Kiskinova, Maya, Sacchi, M., Institut des Nanosciences de Paris ( INSP ), and Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Physics and Astronomy (all), [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], [ PHYS.COND ] Physics [physics]/Condensed Matter [cond-mat]
Abstract

International audience; Thin film magnetization reversal without applying external fields is an attractive perspective for applications in sensors and devices. One way to accomplish it is by fine-tuning the microstructure of a magnetic substrate via temperature control, as in the case of a thin Fe layer deposited on a MnAs/GaAs(001) template. This work reports a time-resolved resonant scattering study exploring the magnetic and structural properties of the Fe/MnAs system, using a 100 fs optical laser pulse to trigger local temperature variations and a 100 fs x-ray free-electron laser pulse to probe the induced magnetic and structural dynamics. The experiment provides direct evidence that a single optical laser pulse can reverse the Fe magnetization locally. It reveals that the time scale of the magnetization reversal is slower than that of the MnAs structural transformations triggered by the optical pulse, which take place after a few picoseconds already.

Published
2014

79. Design and development of the multilayer optics for the new hard x-ray mission

Author

Citterio, O., primary, Civitani, M., primary, Raimondi, L., primary, Sironi, G., primary, Cotroneo, V., primary, Borghi, G., primary, Vernani, D., primary, Valsecchi, G., primary, Binda, R., primary, Gorenstein, P., primary, Attinà, P., primary, Pareschi, G., primary, Basso, S., primary, Spiga, D., primary, Tagliaferri, G., primary, Negri, B., primary, Parodi, Giancarlo, primary, Martelli, F., primary, Orlandi, A., primary, and Romaine, S., primary

Published
2017
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80. Probing ultrafast changes of spin and charge density profiles with resonant XUV magnetic reflectivity at the free-electron laser FERMI

Author

Gutt, C., primary, Sant, T., additional, Ksenzov, D., additional, Capotondi, F., additional, Pedersoli, E., additional, Raimondi, L., additional, Nikolov, I. P., additional, Kiskinova, M., additional, Jaiswal, S., additional, Jakob, G., additional, Kläui, M., additional, Zabel, H., additional, and Pietsch, U., additional

Published
2017
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81. The EIS beamline at the seeded free-electron laser FERMI

Author

Simoncig, A., additional, Mincigrucci, R., additional, Principi, E., additional, Bencivenga, F., additional, Calvi, A., additional, Foglia, L., additional, Kurdi, G., additional, Raimondi, L., additional, Manfredda, M., additional, Mahne, N., additional, Gobessi, R., additional, Gerusina, S., additional, Fava, C., additional, Zangrando, M., additional, Matruglio, A., additional, Dal Zilio, S., additional, Masciotti, V., additional, and Masciovecchio, C., additional

Published
2017
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84. Ultrafast spin-switching of a ferrimagnetic alloy at room temperature traced by resonant magneto-optical Kerr effect using a seeded FEL

Author

Yamamoto, Sh, Taguchi, M., Someya, T., Kubota, Y., Ito, S., Wadati, H., Fujisawa, M., Capotondi, F., Pedersoli, E., Manfredda, M., Raimondi, L., Kiskinova, M., Fujii, J., Moras, P., Tsuyama, T., Nakamura, T., Kato, T., Higashide, T., Iwata, S., Yamamoto, S., Shin, S., and Matsuda, I.

Subjects
Physics::Optics, free electron laser, resonant magneto-optical Kerr effect
Abstract

Ultrafast magnetization reversal of a ferrimagnetic metallic alloy GdFeCo was investigated by time-resolved resonant magneto-optical Kerr effect measurements using a seeded free electron laser. The GdFeCo alloy was pumped by a linearly polarized optical laser pulse, and the following temporal evolution of the magnetization of Fe in GdFeCo was element-selectively traced by a probe free electron laser pulse with a photon energy tuned to the Fe M-edge. The results have been measured using rotating analyzer ellipsometry method and confirmed magnetization switching caused by ultrafast heating.

Published
2015

87. Extreme ultraviolet resonant inelastic X-ray scattering (RIXS) at a seeded free-electron laser

Author

Dell'Angela, M., Hieke, F., Malvestuto, M., Sturari, L., Bajt, S., Kozhevnikov, I. V., Ratanapreechachai, J., Caretta, A., Casarin, B., Glerean, F., Kalashnikova, A. M., Pisarev, R. V., Chuang, Y. -D., Manzoni, G., Cilento, F., Mincigrucci, R., Simoncig, A., Principi, E., Masciovecchio, C., Raimondi, L., Mahne, N., Svetina, C., Zangrando, M., Passuello, R., Gaio, G., Prica, M., Scarcia, M., Kourousias, G., Borghes, R., Giannessi, L., Wurth, W., Parmigiani, F., Dell'Angela, M., Hieke, F., Malvestuto, M., Sturari, L., Bajt, S., Kozhevnikov, I. V., Ratanapreechachai, J., Caretta, A., Casarin, B., Glerean, F., Kalashnikova, A. M., Pisarev, R. V., Chuang, Y. -D., Manzoni, G., Cilento, F., Mincigrucci, R., Simoncig, A., Principi, E., Masciovecchio, C., Raimondi, L., Mahne, N., Svetina, C., Zangrando, M., Passuello, R., Gaio, G., Prica, M., Scarcia, M., Kourousias, G., Borghes, R., Giannessi, L., Wurth, W., and Parmigiani, F.

Abstract

In the past few years, we have been witnessing an increased interest for studying materials properties under non-equilibrium conditions. Several well established spectroscopies for experiments in the energy domain have been successfully adapted to the time domain with sub-picosecond time resolution. Here we show the realization of high resolution resonant inelastic X-ray scattering (RIXS) with a stable ultrashort X-ray source such as an externally seeded free electron laser (FEL). We have designed and constructed a RIXS experimental endstation that allowed us to successfully measure the d-d excitations in KCoF3 single crystals at the cobalt M-2,M-3-edge at FERMI FEL (Elettra-Sincrotrone Trieste, Italy). The FEL-RIXS spectra show an excellent agreement with the ones obtained from the same samples at the MERIXS endstation of the MERLIN beamline at the Advanced Light Source storage ring (Berkeley, USA). We established experimental protocols for performing time resolved RIXS experiments at a FEL source to avoid X ray-induced sample damage, while retaining comparable acquisition time to the synchrotron based measurements. Finally, we measured and modelled the influence of the FEL mixed electromagnetic modes, also present in externally seeded FELs, and the beam transport with similar to 120 meV experimental resolution achieved in the presented RIXS setup.

Published
2016

93. Coherent control with a short-wavelength free-electron laser

Author

Prince, K. C., primary, Allaria, E., additional, Callegari, C., additional, Cucini, R., additional, De Ninno, G., additional, Di Mitri, S., additional, Diviacco, B., additional, Ferrari, E., additional, Finetti, P., additional, Gauthier, D., additional, Giannessi, L., additional, Mahne, N., additional, Penco, G., additional, Plekan, O., additional, Raimondi, L., additional, Rebernik, P., additional, Roussel, E., additional, Svetina, C., additional, Trovò, M., additional, Zangrando, M., additional, Negro, M., additional, Carpeggiani, P., additional, Reduzzi, M., additional, Sansone, G., additional, Grum-Grzhimailo, A. N., additional, Gryzlova, E. V., additional, Strakhova, S. I., additional, Bartschat, K., additional, Douguet, N., additional, Venzke, J., additional, Iablonskyi, D., additional, Kumagai, Y., additional, Takanashi, T., additional, Ueda, K., additional, Fischer, A., additional, Coreno, M., additional, Stienkemeier, F., additional, Ovcharenko, Y., additional, Mazza, T., additional, and Meyer, M., additional

Published
2016
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94. Four-wave-mixing experiments with seeded free electron lasers

Author

Bencivenga, F., primary, Calvi, A., additional, Capotondi, F., additional, Cucini, R., additional, Mincigrucci, R., additional, Simoncig, A., additional, Manfredda, M., additional, Pedersoli, E., additional, Principi, E., additional, Dallari, F., additional, Duncan, R. A., additional, Izzo, M. G., additional, Knopp, G., additional, Maznev, A. A., additional, Monaco, G., additional, Di Mitri, S., additional, Gessini, A., additional, Giannessi, L., additional, Mahne, N., additional, Nikolov, I. P., additional, Passuello, R., additional, Raimondi, L., additional, Zangrando, M., additional, and Masciovecchio, C., additional

Published
2016
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97. Effects of thyroid hormones on RNA-binding proteins involved the regulation on H1° and H3,3 histone variant expression

Author

COMPAGNO, Vincenza, SALA, Anna, CAMPO, Antonina, FAVALORO, Valentina, DONATELLI, Maria, RAIMONDI L, BONO E, SAMMARTINO C, AGRIGENTO V, LO PRESTI MD, CUSIMANO M, SAVASTA FL, MOCCIARO AM, DI LIEGRO, Italia, COMPAGNO V, RAIMONDI L, BONO E, SAMMARTINO C, AGRIGENTO V, SALA A, CAMPO A, LO PRESTI MD, CUSIMANO M, SAVASTA FL, FAVALORO V, MOCCIARO AM, DONATELLI M, and DI LIEGRO I

Published
2004

98. Effects of thyroid hormones on RNA-binding proteins involved in the regulation of H1° and H3.3 histone variant expression

Author

COMPAGNO, Vincenza, SALA, Anna, FAVALORO, Valentina, DONATELLI, Maria, DI LIEGRO, Italia, RAIMONDI, L, BONO, E, SAMMARTINO, C, AGRIGENTO, V, CAMPO, V, LO PRESTI, MD, CUSIMANO, M, SAVASTA, FL, MOCCIARO, AM, COMPAGNO, V, RAIMONDI, L, BONO, E, SAMMARTINO, C, AGRIGENTO, V, SALA, A, CAMPO, V, LO PRESTI, MD, CUSIMANO, M, SAVASTA, FL, FAVALORO, V, MOCCIARO, AM, DONATELLI, M, and DI LIEGRO, I

Published
2004

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