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51. Beam Asymmetry $\mathbf{\Sigma}$ for the Photoproduction of $\mathbf{\eta}$ and $\mathbf{\eta^{\prime}}$ Mesons at $\mathbf{E_{\gamma}=8.8}$GeV

Author: The GlueX Collaboration, Adhikari, S., Ali, A., Amaryan, M., Austregesilo, A., Barbosa, F., Barlow, J., Barnes, A., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Boer, M., Briscoe, W. J., Britton, T., Brooks, W. K., Cannon, B. E., Cao, N., Chudakov, E., Cole, S., Cortes, O., Crede, V., Dalton, M. M., Daniels, T., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Egiyan, H., Erbora, T., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Foda, A. M., Foote, J., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gevorgyan, N., Gleason, C., Goetzen, K., Goncalves, A., Goryachev, V. S., Guo, L., Hakobyan, H., Hamdi, A., Huber, G. M., Hurley, A., Ireland, D. G., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kalicy, G., Kamel, M., Kourkoumelis, C., Kuleshov, S., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W., Liu, B., Livingston, K., Lolos, G. J., Lyubovitskij, V., Mack, D., Marukyan, H., Mattione, P., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., Meyer, C. A., Miskimen, R., Mitchell, R. E., Nerling, F., Ng, L., Ostrovidov, A. I., Papandreou, Z., Patsyuk, M., Paudel, C., Pauli, P., Pedroni, R., Pentchev, L., Peters, K. J., Phelps, W., Pooser, E., Qin, N., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Romero, C., Salgado, C., Schertz, A. M., Schumacher, R. A., Schwiening, J., Semenov, A. Yu., Semenova, I. A., Seth, K. K., Shen, X., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Staib, M., Stevens, J. R., Strakovsky, I. I., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Vasileiadis, G., Whitlatch, T., Wickramaarachchi, N., Williams, M., Xiao, T., Yang, Y., Zarling, J., Zhang, Z., Zhao, G., Zhou, Q., Zhou, X., and Zihlmann, B.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: We report on the measurement of the beam asymmetry $\Sigma$ for the reactions $\vec{\gamma}p\rightarrow p\eta$ and $\vec{\gamma}p \rightarrow p\eta^{\prime}$ from the GlueX experiment, using an 8.2--8.8 GeV linearly polarized tagged photon beam incident on a liquid hydrogen target in Hall D at Jefferson Lab. These measurements are made as a function of momentum transfer $-t$, with significantly higher statistical precision than our earlier $\eta$ measurements, and are the first measurements of $\eta^{\prime}$ in this energy range. We compare the results to theoretical predictions based on $t$--channel quasi-particle exchange. We also compare the ratio of $\Sigma_{\eta}$ to $\Sigma_{\eta^{\prime}}$ to these models, as this ratio is predicted to be sensitive to the amount of $s\bar{s}$ exchange in the production. We find that photoproduction of both $\eta$ and $\eta^{\prime}$ is dominated by natural parity exchange with little dependence on $-t$., Comment: 18 pages, 7 figures
Published: 2019
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52. First measurement of near-threshold J/$\psi $ exclusive photoproduction off the proton

Author: The GlueX Collaboration, Ali, A., Amaryan, M., Anassontzis, E. G., Austregesilo, A., Baalouch, M., Barbosa, F., Barlow, J., Barnes, A., Barriga, E., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Boer, M., Briscoe, W. J., Britton, T., Brooks, W. K., Cannon, B. E., Cao, N., Chudakov, E., Cole, S., Cortes, O., Crede, V., Dalton, M. M., Daniels, T., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Egiyan, H., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Foda, A. M., Foote, J., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gauzshtein, V., Gevorgyan, N., Gleason, C., Goetzen, K., Goncalves, A., Goryachev, V. S., Guo, L., Hakobyan, H., Hamdi, A., Han, S., Hardin, J., Huber, G. M., Hurley, A., Ireland, D. G., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kalicy, G., Kamel, M., Kourkoumelis, C., Kuleshov, S., Kuznetsov, I., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W., Liu, B., Livingston, K., Lolos, G. J., Lyubovitskij, V., Mack, D., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., McIntyre, J., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mokaya, F., Nerling, F., Ng, L., Ostrovidov, A. I., Papandreou, Z., Patsyuk, M., Pauli, P., Pedroni, R., Pentchev, L., Peters, K. J., Phelps, W., Pooser, E., Qin, N., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Romero, C., Salgado, C., Schertz, A. M., Schumacher, R. A., Schwiening, J., Seth, K. K., Shen, X., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Stevens, J. R., Strakovsky, I. I., Suresh, K., Tarasov, V., Taylor, S., Teymurazyan, A., Thiel, A., Vasileiadis, G., Werthmueller, D., Whitlatch, T., Wickramaarachchi, N., Williams, M., Xiao, T., Yang, Y., Zarling, J., Zhang, Z., Zhao, G., Zhou, Q., Zhou, X., and Zihlmann, B.
Subjects: Nuclear Experiment
Abstract: We report on the measurement of the $\gamma p \rightarrow J/\psi p$ cross section from $E_\gamma = 11.8$ GeV down to the threshold at $8.2$ GeV using a tagged photon beam with the GlueX experiment. We find the total cross section falls toward the threshold less steeply than expected from two-gluon exchange models. The differential cross section $d\sigma /dt$ has an exponential slope of $1.67 \pm 0.39$ GeV$^{-2}$ at $10.7$ GeV average energy. The LHCb pentaquark candidates $P_c^+$ can be produced in the $s$-channel of this reaction. We see no evidence for them and set model-dependent upper limits on their branching fractions $\mathcal{B}(P_c^+ \rightarrow J/\psi p)$ and cross sections $\sigma(\gamma p \to P_c^+)\times\mathcal{B}(P_c^+ \to J/\psi p) $., Comment: 12 pages, 7 figures
Published: 2019
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53. Detector requirements and simulation results for the EIC exclusive, diffractive and tagging physics program using the ECCE detector concept

Author: Bylinkin, A., Dean, C.T., Fegan, S., Gangadharan, D., Gates, K., Kay, S.J.D., Korover, I., Li, W.B., Li, X., Montgomery, R., Nguyen, D., Penman, G., Pybus, J.R., Santiesteban, N., Shimizu, S., Trotta, R., Usman, A., Baker, M.D., Frantz, J., Glazier, D.I., Higinbotham, D.W., Horn, T., Huang, J., Huber, G.M., Reed, R., Roche, J., Schmidt, A., Steinberg, P., Stevens, J., Goto, Y., Munoz Camacho, C., Murray, M., Papandreou, Z., Zha, W., Adkins, J.K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I.C., Ayerbe Gayoso, C., Bae, J., Bai, X., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J.C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W.J., Brooks, M., Bueltmann, S., Bukhari, M.H.S., Capobianco, R., Chang, W.-C., Cheon, Y., Chen, K., Chen, K.-F., Cheng, K.-Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Corrales Morales, Y., Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J.M., Dzhygadlo, R., Ehlers, R., El Fassi, L., Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Finger, M., Finger, M., Jr, Friedman, M., Friscic, I., Gardner, S., Geurts, F., Gilman, R., Glimos, E., Grau, N., Greene, S.V., Guo, A.Q., Guo, L., Ha, S.K., Haggerty, J., Hayward, T., He, X., Hen, O., Hoballah, M., Hoghmrtsyan, A., Hsu, P.-h.J., Hutson, A., Hwang, K.Y., Hyde, C.E., Inaba, M., Iwata, T., Jo, H.S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S.H., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C.-M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J.S.H., Lee, S.W., Lee, Y.-J., Li, W., Liang, Y.T., Lim, S., Lin, C.-h., Lin, D.X., Liu, K., Liu, M.X., Livingston, K., Liyanage, N., Llope, W.J., Loizides, C., Long, E., Lu, R.-S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R.G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Morrison, D., Movsisyan, A., Mkrtchyan, H., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V.A., Orešić, S., Osborn, J.D., O’Shaughnessy, C., Paganis, S., Pate, S.F., Patel, M., Paus, C., Perdekamp, M.G., Perepelitsa, D.V., Periera da Costa, H., Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M.L., Putschke, J., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K.F., Røed, K., Reinhold, J., Renner, E.L., Richards, J., Riedl, C., Rinn, T., Roland, G.M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santos, R., Sarsour, M., Schambach, J., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T.-A., Shih, C.-W., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I.I., Stepanov, P., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W.-C., Tapia Araya, S., Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Tveter, T.S., Umaka, E., van Hecke, H.W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P.K., Wang, Q., Wang, Y., Watts, D.P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C.-P., Wood, L., Wood, M.H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H.D., Yurov, M., Zachariou, N., Zajc, W.A., Zhang, J.-L., Zhang, J.-X., Zhang, Y., Zhao, Y.-X., Zheng, X., and Zhuang, P.
Published: 2023
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54. Exclusive π+ electroproduction off the proton from low to high -t

Author: Basnet, S, Huber, GM, Li, WB, Blok, HP, Gaskell, D, Horn, T, Aniol, K, Arrington, J, Beise, EJ, Boeglin, W, Brash, EJ, Breuer, H, Chang, CC, Christy, ME, Ent, R, Gibson, E, Holt, RJ, Jin, S, Jones, MK, Keppel, CE, Kim, W, King, PM, Kovaltchouk, V, Liu, J, Lolos, GJ, MacK, DJ, Margaziotis, DJ, Markowitz, P, Matsumura, A, Meekins, D, Miyoshi, T, Mkrtchyan, H, Niculescu, I, Okayasu, Y, Pentchev, L, Perdrisat, C, Potterveld, D, Punjabi, V, Reimer, P, Reinhold, J, Roche, J, Sarty, A, Smith, GR, Tadevosyan, V, Tang, LG, Tvaskis, V, Volmer, J, Vulcan, W, Warren, G, Wood, SA, Xu, C, and Zheng, X
Subjects: nucl-ex, hep-ex
Abstract: Background: Measurements of exclusive meson production are a useful tool in the study of hadronic structure. In particular, one can discern the relevant degrees of freedom at different distance scales through these studies. Purpose: To study the transition between nonperturbative and perturbative quantum chromodynamics as the square of four-momentum transfer to the struck proton, -t, is increased. Method: Cross sections for the H1(e,e′π+)n reaction were measured over the -t range of 0.272 to 2.127 GeV2 with limited azimuthal coverage at fixed beam energy of 4.709 GeV, Q2 of 2.4 GeV2, and W of 2.0 GeV at the Thomas Jefferson National Accelerator Facility (JLab) Hall C. Results: The -t dependence of the measured π+ electroproduction cross section generally agrees with prior data from JLab Halls B and C. The data are consistent with a Regge amplitude-based theoretical model but show poor agreement with a generalized parton distribution-based model. Conclusion: The agreement of cross sections with prior data implies small contribution from the interference terms, and the confirmation of the change in t slopes between the low- and high - t regions previously observed in photoproduction indicates the changing nature of the electroproduction reaction in our kinematic regime.
Published: 2019

55. Exclusive π+ electroproduction off the proton from low to high −t

Author: Basnet, S, Huber, GM, Li, WB, Blok, HP, Gaskell, D, Horn, T, Aniol, K, Arrington, J, Beise, EJ, Boeglin, W, Brash, EJ, Breuer, H, Chang, CC, Christy, ME, Ent, R, Gibson, E, Holt, RJ, Jin, S, Jones, MK, Keppel, CE, Kim, W, King, PM, Kovaltchouk, V, Liu, J, Lolos, GJ, Mack, DJ, Margaziotis, DJ, Markowitz, P, Matsumura, A, Meekins, D, Miyoshi, T, Mkrtchyan, H, Niculescu, I, Okayasu, Y, Pentchev, L, Perdrisat, C, Potterveld, D, Punjabi, V, Reimer, P, Reinhold, J, Roche, J, Sarty, A, Smith, GR, Tadevosyan, V, Tang, LG, Tvaskis, V, Volmer, J, Vulcan, W, Warren, G, Wood, SA, Xu, C, and Zheng, X
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, nucl-ex, hep-ex, Nuclear and plasma physics
Abstract: Background: Measurements of exclusive meson production are a useful tool in the study of hadronic structure. In particular, one can discern the relevant degrees of freedom at different distance scales through these studies. Purpose: To study the transition between nonperturbative and perturbative quantum chromodynamics as the square of four-momentum transfer to the struck proton, -t, is increased. Method: Cross sections for the H1(e,e′π+)n reaction were measured over the -t range of 0.272 to 2.127 GeV2 with limited azimuthal coverage at fixed beam energy of 4.709 GeV, Q2 of 2.4 GeV2, and W of 2.0 GeV at the Thomas Jefferson National Accelerator Facility (JLab) Hall C. Results: The -t dependence of the measured π+ electroproduction cross section generally agrees with prior data from JLab Halls B and C. The data are consistent with a Regge amplitude-based theoretical model but show poor agreement with a generalized parton distribution-based model. Conclusion: The agreement of cross sections with prior data implies small contribution from the interference terms, and the confirmation of the change in t slopes between the low- and high - t regions previously observed in photoproduction indicates the changing nature of the electroproduction reaction in our kinematic regime.
Published: 2019

56. ECCE sensitivity studies for single hadron transverse single spin asymmetry measurements

Author: Seidl, R., Vladimirov, A., Pitonyak, D., Prokudin, A., Adkins, J.K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I.C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M.D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J.C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W.J., Brooks, M., Bueltmann, S., Bukhari, M.H.S., Bylinkin, A., Capobianco, R., Chang, W.-C., Cheon, Y., Chen, K., Chen, K.-F., Cheng, K.-Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C.T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J.M., Dzhygadlo, R., Ehlers, R., El Fassi, L., Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger, M., Jr., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S.V., Guo, A.Q., Guo, L., Ha, S.K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D.W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P.-h.J., Huang, J., Huber, G., Hutson, A., Hwang, K.Y., Hyde, C.E., Inaba, M., Iwata, T., Jo, H.S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S.J.D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S.H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C.-M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J.S.H., Lee, S.W., Lee, Y.-J., Li, W., Li, W.B., Li, X., Liang, Y.T., Lim, S., Lin, C.-H., Lin, D.X., Liu, K., Liu, M.X., Livingston, K., Liyanage, N., Llope, W.J., Loizides, C., Long, E., Lu, R.-S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R.G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V.A., Orešić, S., Osborn, J.D., O’Shaughnessy, C., Paganis, S., Papandreou, Z., Pate, S.F., Patel, M., Paus, C., Penman, G., Perdekamp, M.G., Perepelitsa, D.V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M.L., Putschke, J., Pybus, J.R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K.F., Røed, K., Reed, R., Reinhold, J., Renner, E.L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G.M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T.-A., Shih, C.-W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I.I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W.-C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T.S., Umaka, E., Usman, A., van Hecke, H.W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P.K., Wang, Q., Wang, Y., Watts, D.P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C.-P., Wood, L., Wood, M.H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H.D., Yurov, M., Zachariou, N., Zajc, W.A., Zha, W., Zhang, J.-L., Zhang, J.-X., Zhang, Y., Zhao, Y.-X., Zheng, X., and Zhuang, P.
Published: 2023
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57. Exclusive J/[formula omitted] detection and physics with ECCE

Author: Li, X., Adkins, J.K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I.C., Ayerbe Gayoso, C., Bae, J., Bai, X., Baker, M.D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J.C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W.J., Brooks, M., Bueltmann, S., Bukhari, M.H.S., Bylinkin, A., Capobianco, R., Chang, W.-C., Cheon, Y., Chen, K., Chen, K.-F., Cheng, K.-Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Corrales Morales, Y., Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C.T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J.M., Dzhygadlo, R., Ehlers, R., El Fassi, L., Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger, M., Jr., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S.V., Guo, A.Q., Guo, L., Ha, S.K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D.W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P.-h.J., Huang, J., Huber, G., Hutson, A., Hwang, K.Y., Hyde, C.E., Inaba, M., Iwata, T., Jo, H.S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S.J.D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S.H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C.-M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J.S.H., Lee, S.W., Lee, Y.-J., Li, W., Li, W.B., Liang, Y.T., Lim, S., Lin, C.-H., Lin, D.X., Liu, K., Liu, M.X., Livingston, K., Liyanage, N., Llope, W.J., Loizides, C., Long, E., Lu, R.-S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R.G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Munoz Camacho, C., Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V.A., Orešić, S., Osborn, J.D., O’Shaughnessy, C., Paganis, S., Papandreou, Z., Pate, S.F., Patel, M., Paus, C., Penman, G., Perdekamp, M.G., Perepelitsa, D.V., Periera da Costa, H., Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M.L., Putschke, J., Pybus, J.R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K.F., Røed, K., Reed, R., Reinhold, J., Renner, E.L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G.M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T.-A., Shih, C.-W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I.I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W.-C., Tapia Araya, S., Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T.S., Umaka, E., Usman, A., van Hecke, H.W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P.K., Wang, Q., Wang, Y., Watts, D.P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C.-P., Wood, L., Wood, M.H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H.D., Yurov, M., Zachariou, N., Zajc, W.A., Zha, W., Zhang, J.-L., Zhang, J.-X., Zhang, Y., Zhao, Y.-X., Zheng, X., and Zhuang, P.
Published: 2023
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58. Scientific computing plan for the ECCE detector at the Electron Ion Collider

Author: Bernauer, J.C., Dean, C.T., Fanelli, C., Huang, J., Kauder, K., Lawrence, D., Osborn, J.D., Paus, C., Adkins, J.K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I.C., Ayerbe Gayoso, C., Bae, J., Bai, X., Baker, M.D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W.J., Brooks, M., Bueltmann, S., Bukhari, M.H.S., Bylinkin, A., Capobianco, R., Chang, W.-C., Cheon, Y., Chen, K., Chen, K.-F., Cheng, K.-Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Corrales Morales, Y., Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J.M., Dzhygadlo, R., Ehlers, R., El Fassi, L., Emmert, A., Ent, R., Fatemi, R., Fegan, S., Finger, M., Finger, M., Jr., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S.V., Guo, A.Q., Guo, L., Ha, S.K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D.W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P.-h.J., Huber, G., Hutson, A., Hwang, K.Y., Hyde, C., Inaba, M., Iwata, T., Jo, H.S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S.J.D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S.H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C.-M., Kutz, T., Lajoie, J., Lebedev, S., Lee, H., Lee, J.S.H., Lee, S.W., Lee, Y.-J., Li, W., Li, X., Liang, Y.T., Lim, S., Lin, C.-h., Lin, D.X., Liu, K., Liu, M.X., Livingston, K., Liyanage, N., Llope, W.J., Loizides, C., Long, E., Lu, R.-S., Lu, Z., Lynch, W., Marchand, D., Marcisovsky, M., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R.G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Munoz Camacho, C., Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V.A., Orešić, S., O’Shaughnessy, C., Paganis, S., Papandreou, Z., Pate, S.F., Patel, M., Penman, G., Perdekamp, M.G., Perepelitsa, D.V., Periera da Costa, H., Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M.L., Putschke, J., Pybus, J.R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K., Røed, K., Reed, R., Reinhold, J., Renner, E.L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G.M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T.-A., Shih, C.-W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I.I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W.-C., Tapia Araya, S., Tarafdar, S., Teodorescu, L., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T.S., Umaka, E., Usman, A., van Hecke, H.W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P.K., Wang, Q., Wang, Y., Watts, D.P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C.-P., Wood, L., Wood, M.H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H.D., Yurov, M., Zachariou, N., Zajc, W.A., Zhang, J., Zhang, Y., Zhao, Y.X., Zheng, X., and Zhuang, P.
Published: 2023
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59. AI-assisted optimization of the ECCE tracking system at the Electron Ion Collider

Author: Fanelli, C., Papandreou, Z., Suresh, K., Adkins, J.K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I.C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M.D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J.C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W.J., Brooks, M., Bueltmann, S., Bukhari, M.H.S., Bylinkin, A., Capobianco, R., Chang, W.-C., Cheon, Y., Chen, K., Chen, K.-F., Cheng, K.-Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C.T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J.M., Dzhygadlo, R., Ehlers, R., El Fassi, L., Emmert, A., Ent, R., Fatemi, R., Fegan, S., Finger, M., Finger, M., Jr, Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S.V., Guo, A.Q., Guo, L., Ha, S.K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D.W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P.-h.J., Huang, J., Huber, G., Hutson, A., Hwang, K.Y., Hyde, C.E., Inaba, M., Iwata, T., Jo, H.S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S.J.D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S.H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C.-M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J.S.H., Lee, S.W., Lee, Y.-J., Li, W., Li, W.B., Li, X., Liang, Y.T., Lim, S., Lin, C.-H., Lin, D.X., Liu, K., Liu, M.X., Livingston, K., Liyanage, N., Llope, W.J., Loizides, C., Long, E., Lu, R.-S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R.G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V.A., Orešić, S., Osborn, J.D., O’Shaughnessy, C., Paganis, S., Pate, S.F., Patel, M., Paus, C., Penman, G., Perdekamp, M.G., Perepelitsa, D.V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M.L., Putschke, J., Pybus, J.R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K.F., Røed, K., Reed, R., Reinhold, J., Renner, E.L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G.M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T.-A., Shih, C.-W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I.I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Tadevosyan, V., Tang, W.-C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T.S., Umaka, E., Usman, A., van Hecke, H.W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P.K., Wang, Q., Wang, Y., Watts, D.P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C.-P., Wood, L., Wood, M.H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H.D., Yurov, M., Zachariou, N., Zajc, W.A., Zha, W., Zhang, J.-L., Zhang, J.-X., Zhang, Y., Zhao, Y.-X., Zheng, X., and Zhuang, P.
Published: 2023
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60. High-resolution hypernuclear spectroscopy at Jefferson Lab, Hall A

Author: Jefferson Lab Hall A Collaboration, Garibaldi, F., Acha, A., Ambrozewicz, P., Aniol, K. A., Beturin, P., Benaoum, H., Benesch, J., Bertin, P. Y., Blomqvist, K. I., Boeglin, W. U., Breuer, H., Brindza, P., Bydzovsky, P., Camsonne, A., Chang, C. C., Chen, J. -P., Choi, Seonho, Chudakov, E. A., Cisbani, E., Colilli, S., Coman, L., Cusanno, F., Craver, B. J., De Cataldo, G., de Jager, C. W., De Leo, R., Deur, A. P., Ferdi, C., Feuerbach, R. J., Folts, E., Frullani, S., Gayou, O., Giuliani, F., Gomez, J., Gricia, M., Hansen, J. O., Hayes, D., Higinbotham, D. W., Holmstrom, T. K., Hyde, C. E., Ibrahim, H. F., Iodice, M., Jiang, X., Kaufman, L. J., Kino, K., Kross, B., Lagamba, L., LeRose, J. J., Lindgren, R. A., Lucentini, M., Margaziotis, D. J., Markowitz, P., Marrone, S., Meekins, D. G., Meziani, Z. E., McCormick, K., Michaels, R. W., Millener, D. J., Miyoshi, T., Moffit, B., Monaghan, P. A., Moteabbed, M., Camacho, C. Munoz, Nanda, S., Nappi, E., Nelyubin, V. V., Norum, B. E., Okasyasu, Y., Paschke, K. D., Perdrisat, C. F., Piasetzky, E., Punjabi, V. A., Qiang, Y., Raue, B., Reimer, P. E., Reinhold, J., Reitz, B., Roche, R. E., Rodriguez, V. M., Saha, A., Santavenere, F., Sarty, A. J., Segal, J., Shahinyan, A., Singh, J., Sirca, S., Snyder, R., Solvignon, P. H., Sotona, M., Subedi, R., Sulkosky, V. A., Suzuki, T., Ueno, H., Ulmer, P. E., Urciuoli, G. M., Voutier, E., Wojtsekhowski, B. B., Zheng, X., and Zorn, C.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: The experiment E94-107 in Hall A at Jefferson Lab started a systematic study of high resolution hypernuclear spectroscopy in the 0p-shell region of nuclei such as the hypernuclei produced in electroproduction on 9Be, 12C and 16O targets. In order to increase counting rates and provide unambiguous kaon identification two superconducting septum magnets and a ring-imaging Cherenkov detector were added to the Hall A standard equipment. The high-quality beam, the good spectrometers and the new experimental devices allowed us to obtain very good results. For the first time, measurable strength with sub-MeV energy resolution was observed for the core-excited states of Lambda 12B. A high-quality Lambda 16N hypernuclear spectrum was likewise obtained. A first measurement of the Lambda binding energy for Lambda 16N, calibrated against the elementary reaction on hydrogen, was obtained with high precision, 13.76 +/- 0.16 MeV. Similarly, the first Lambda 9Li hypernuclear spectrum shows general agreement with theory (distorted-wave impulse approximation with the SLA and BS3 electroproduction models and shell-model wave functions). Some disagreement exists with respect to the relative strength of the states making up the first multiplet. A Lambda separation energy of 8.36 MeV was obtained, in agreement with previous results. It has been shown that the electroproduction of hypernuclei can provide information complementary to that obtained with hadronic probes and the gamma-ray spectroscopy technique., Comment: 27 pages, 18 figures, submitted to Physical Review C
Published: 2018
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61. Measurements of Non-Singlet Moments of the Nucleon Structure Functions and Comparison to Predictions from Lattice QCD for $Q^2 = 4$ $\rm GeV^2$

Author: Albayrak, I., Mamyan, V., Christy, M. E., Ahmidouch, A., Arrington, J., Asaturyan, A., Bodek, A., Bosted, P., Bradford, R., Brash, E., Bruell, A., Butuceanu, C, Coleman, S. J., Commisso, M., Connell, S. H., Dalton, M. M., Danagoulian, S., Daniel, A., Day, D. B., Dhamija, S., Dunne, J., Dutta, D., Ent, R., Gaskell, D., Gasparian, A., Gran, R., Horn, T., Huang, Liting, Huber, G. M., Jayalath, C., Johnson, M., Jones, M. K., Kalantarians, N., Liyanage, A., Keppel, C. E., Kinney, E., Li, Y., Malace, S., Manly, S., Markowitz, P., Maxwell, J., Mbianda, N. N., McFarland, K. S., Meziane, M., Meziani, Z. E., Mills, G. B, Mkrtchyan, H., Mkrtchyan, A., Mulholland, J., Nelson, J., Niculescu, G., Niculescu, I., Pentchev, L., Puckett, A., Punjabi, V., Qattan, I. A., Reimer, P. E., Reinhold, J., Rodriguez, V. M, Rondon-Aramayo, O., Sakuda, M., Sakumoto, W. K., Segbefia, E., Seva, T., Sick, I., Slifer, K., Smith, G. R, Steinman, J., Solvignon, P., Tadevosyan, V., Tajima, S., Tvaskis, V., Smith, G. R., Vulcan, W. F., Walton, T., Wesselmann, F. R, Wood, S. A., and Ye, Zhihong
Subjects: Nuclear Experiment
Abstract: We present extractions of the nucleon non-singlet moments utilizing new precision data on the deuteron $F_2$ structure function at large Bjorken-$x$ determined via the Rosenbluth separation technique at Jefferson Lab Experimental Hall C. These new data are combined with a complementary set of data on the proton previously measured in Hall C at similar kinematics and world data sets on the proton and deuteron at lower $x$ measured at SLAC and CERN. The new Jefferson Lab data provide coverage of the upper third of the $x$ range, crucial for precision determination of the higher moments. In contrast to previous extractions, these moments have been corrected for nuclear effects in the deuteron using a new global fit to the deuteron and proton data. The obtained experimental moments represent an order of magnitude improvement in precision over previous extractions using high $x$ data. Moreover, recent exciting developments in Lattice QCD calculations provide a first ever comparison of these new experimental results with calculations of moments carried out at the physical pion mass, as well as a new approach which first calculates the quark distributions directly before determining moments.
Published: 2018
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62. Proton Form Factor Ratio, $\mu_p G_E^p/G_M^p$ from Double Spin Asymmetry

Author: Liyanage, A., Armstrong, W., Kang, H., Maxwell, J., Mulholland, J., Ndukum, L., Ahmidouch, A., Albayrak, I., Asaturyan, A., Ates, O., Baghdasaryan, H., Boeglin, W., Bosted, P., Brash, E., Butuceanu, C., Bychkov, M., Carter, P., Chen, C., Chen, J-P., Choi, S., Christy, E., Covrig, S., Crabb, D., Danagoulian, S., Daniel, A., Davidenko, A. M., Davis, B., Day, D., Deconinck, W., Deur, A., Dunne, J., Dutta, D., Fassi, L. El, Elaasar, M., Ellis, C., Ent, R., Flay, D., Frlez, E., Gaskell, D., Geagla, O., German, J., Gilman, R., Gogami, T., Gomez, J., Goncharenko, Y. M., Hashimoto, O., Higinbotham, D., Horn, T., Huber, G. M., Jones, M., Jones, M. K., Kalantarians, N., Kang, H-K., Kawama, D., Keppel, C., Khandaker, M., Kim, Y., King, P. M., Kohl, M., Kovacs, K., Kubarovsky, V., Li, Y., Liyanage, N., Mamyan, V., Markowitz, P., Maruta, T., Melnik, Y. M., Meziani, Z-E., Mkrtchyan, A., Mkrtchyan, H., Mochalov, V. V., Monaghan, P., Narayan, A., Nakamura, S. N., Nuruzzaman, Pentchev, L., Pocanic, D., Posik, M., Puckett, A., Qiu, X., Reinhold, J., Riordan, S., Roche, J., Rondo'n, O. A., Sawatzky, B., Shabestari, M., Slifer, K., Smith, G., Soloviev, L. F., Solvignon, P., Tadevosyan, V., Tang, L., Vasiliev, A. N., Veilleux, M., Walton, T., Wesselmann, F., Wood, S. A., Yao, H., Ye, Z., and Zhu, L.
Subjects: Nuclear Experiment
Abstract: The ratio of the electric and magnetic form factor of the proton, $\mu_p G_E^p/G_M^p$, has been measured for elastic electron-proton scattering with polarized beam and target up to four-momentum transfer squared, $Q^2=5.66$ (GeV/c)$^2$ using the double spin asymmetry for target spin orientation aligned nearly perpendicular to the beam momentum direction. This measurement of $\mu_p G_E^p/G_M^p$ agrees with the $Q^2$ dependence of previous recoil polarization data and reconfirms the discrepancy at high $Q^2$ between the Rosenbluth and the polarization-transfer method with a different measurement technique and systematic uncertainties uncorrelated to those of the recoil-polarization measurements. The form factor ratio at $Q^2$=2.06 (GeV/c)$^2$ has been measured as $\mu_p G_E^p/G_M^p = 0.720 \pm 0.176_{stat} \pm 0.039_{sys}$, which is in agreement with an earlier measurement with the polarized target technique at similar kinematics. The form factor ratio at $Q^2$=5.66 (GeV/c)$^2$ has been determined as $\mu_p G_E^p/G_M^p=0.244\pm0.353_{stat}\pm0.013_{sys}$, which represents the highest $Q^2$ reach with the double spin asymmetry with polarized target to date.
Published: 2018
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63. Revealing Color Forces with Transverse Polarized Electron Scattering

Author: Armstrong, W., Kang, H., Liyanage, A., Maxwell, J., Mulholland, J., Ndukum, L., Ahmidouch, A., Albayrak, I., Asaturyan, A., Ates, O., Baghdasaryan, H., Boeglin, W., Bosted, P., Brash, E., Butuceanu, C., Bychkov, M., Carter, P., Chen, C., Chen, J. -P., Choi, S., Christy, M. E., Covrig, S., Crabb, D., Danagoulian, S., Daniel, A., Davidenko, A. M., Davis, B., Day, D., Deconinck, W., Deur, A., Dunne, J., Dutta, D., Fassi, L. El, Ellis, C., Ent, R., Flay, D., Frlez, E., Gaskell, D., Geagla, O., German, J., Gilman, R., Gogami, T., Gomez, J., Goncharenko, Y. M., Hashimoto, O., Higinbotham, D., Horn, T., Huber, G. M., Jones, M., Jones, M. K., Kalantarians, N., Kang, H-K., Kawama, D., Keith, C., Keppel, C., Khandaker, M., Kim, Y., King, P. M., Kohl, M., Kovacs, K., Kubarovsky, V., Li, Y., Liyanage, N., Luo, W., Mack, D., Mamyan, V., Markowitz, P., Maruta, T., Meekins, D., Melnik, Y. M., Meziani, Z. -E., Mkrtchyan, A., Mkrtchyan, H., Mochalov, V. V., Monaghan, P., Narayan, A., Nakamura, S. N., Nuruzzaman, A., Pentchev, L., Pocanic, D., Posik, M., Puckett, A., Qiu, X., Reinhold, J., Riordan, S., Roche, J., Rondón, O. A., Sawatzky, B., Shabestari, M., Slifer, K., Smith, G., Soloviev, L. F., Solvignon, P., Tadevosyan, V., Tang, L., Vasiliev, A. N., Veilleux, M., Walton, T., Wesselmann, F., Wood, S., Yao, H., Ye, Z., Zhang, J., and Zhu, L.
Subjects: Nuclear Experiment
Abstract: The Spin Asymmetries of the Nucleon Experiment (SANE) measured two double spin asymmetries using a polarized proton target and polarized electron beam at two beam energies, 4.7 GeV and 5.9 GeV. A large-acceptance open-configuration detector package identified scattered electrons at 40$^{\circ}$ and covered a wide range in Bjorken $x$ ($0.3 < x < 0.8$). Proportional to an average color Lorentz force, the twist-3 matrix element, $\tilde{d}_2^p$, was extracted from the measured asymmetries at $Q^2$ values ranging from 2.0 to 6.0 GeV$^2$. The data display the opposite sign compared to most quark models, including the lattice QCD result, and an apparently unexpected scale dependence. Furthermore when combined with the neutron data in the same $Q^2$ range the results suggest a flavor independent average color Lorentz force.
Published: 2018
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64. Separated Kaon Electroproduction Cross Section and the Kaon Form Factor from 6 GeV JLab Data

Author: Carmignotto, M., Ali, S., Aniol, K., Arrington, J., Barrett, B., Beise, E. J., Blok, H. P., Boeglin, W., Brash, E. J., Breuer, H., Chang, C. C., Christy, M. E., Dittmann, A., Ent, R., Fenker, H., Gaskell, D., Gibson, E., Holt, R. J., Horn, T., Huber, G. M., Jin, S., Jones, M. K., Keppel, C. E., Kim, W., King, P. M., Kovaltchouk, V., Liu, J., Lolos, G. J., Mack, D. J., Margaziotis, D. J., Markowitz, P., Matsumura, A., Meekins, D., Miyoshi, T., Mkrtchyan, H., Niculescu, G., Niculescu, I., Okayasu, Y., Pegg, I., Pentchev, L., Perdrisat, C., Potterveld, D., Punjabi, V., Reimer, P. E., Reinhold, J., Roche, J., Sarty, A., Smith, G. R., Tadevosyan, V., Tang, L. G., Trotta, R., Tvaskis, V., Vargas, A., Vidakovic, S., Volmer, J., Vulcan, W., Warren, G., Wood, S. A., Xu, C., and Zheng, X.
Subjects: Nuclear Experiment
Abstract: The $^{1}H$($e,e^\prime K^+$)$\Lambda$ reaction was studied as a function of the Mandelstam variable $-t$ using data from the E01-004 (FPI-2) and E93-018 experiments that were carried out in Hall C at the 6 GeV Jefferson Lab. The cross section was fully separated into longitudinal and transverse components, and two interference terms at four-momentum transfers $Q^2$ of 1.00, 1.36 and 2.07 GeV$^2$. The kaon form factor was extracted from the longitudinal cross section using the Regge model by Vanderhaeghen, Guidal, and Laget. The results establish the method, previously used successfully for pion analyses, for extracting the kaon form factor. Data from 12 GeV Jefferson Lab experiments are expected to have sufficient precision to distinguish between theoretical predictions, for example recent perturbative QCD calculations with modern parton distribution amplitudes. The leading-twist behavior for light mesons is predicted to set in for values of $Q^2$ between 5-10 GeV$^2$, which makes data in the few GeV regime particularly interesting. The $Q^2$ dependence at fixed $x$ and $-t$ of the longitudinal cross section we extracted seems consistent with the QCD factorization prediction within the experimental uncertainty.
Published: 2018
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65. Unique Access to u-Channel Physics: Exclusive Backward-Angle Omega Meson Electroproduction

Author: Li, WB, Huber, GM, Blok, HP, Gaskell, D, Horn, T, Semenov-Tian-Shansky, K, Pire, B, Szymanowski, L, Laget, J-M, Aniol, K, Arrington, J, Beise, EJ, Boeglin, W, Brash, EJ, Breuer, H, Chang, CC, Christy, ME, Ent, R, Gibson, EF, Holt, RJ, Jin, S, Jones, MK, Keppel, CE, Kim, W, King, PM, Kovaltchouk, V, Liu, J, Lolos, GJ, Mack, DJ, Margaziotis, DJ, Markowitz, P, Matsumura, A, Meekins, D, Miyoshi, T, Mkrtchyan, H, Niculescu, I, Okayasu, Y, Pentchev, L, Perdrisat, C, Potterveld, D, Punjabi, V, Reimer, PE, Reinhold, J, Roche, J, Roos, PG, Sarty, A, Smith, GR, Tadevosyan, V, Tang, LG, Tvaskis, V, Volmer, J, Vulcan, W, Warren, G, Wood, SA, Xu, C, and Zheng, X
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Jefferson Lab Fπ Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract: Backward-angle meson electroproduction above the resonance region, which was previously ignored, is anticipated to offer unique access to the three quark plus sea component of the nucleon wave function. In this Letter, we present the first complete separation of the four electromagnetic structure functions above the resonance region in exclusive ω electroproduction off the proton, ep→e^{'}pω, at central Q^{2} values of 1.60, 2.45 GeV^{2}, at W=2.21 GeV. The results of our pioneering -u≈-u_{min} study demonstrate the existence of a unanticipated backward-angle cross section peak and the feasibility of full L/T/LT/TT separations in this never explored kinematic territory. At Q^{2}=2.45 GeV^{2}, the observed dominance of σ_{T} over σ_{L}, is qualitatively consistent with the collinear QCD description in the near-backward regime, in which the scattering amplitude factorizes into a hard subprocess amplitude and baryon to meson transition distribution amplitudes: universal nonperturbative objects only accessible through backward-angle kinematics.
Published: 2019

66. Measurements of Nonsinglet Moments of the Nucleon Structure Functions and Comparison to Predictions from Lattice QCD for Q2=4 GeV2

Author: Albayrak, I, Mamyan, V, Christy, ME, Ahmidouch, A, Arrington, J, Asaturyan, A, Bodek, A, Bosted, P, Bradford, R, Brash, E, Bruell, A, Butuceanu, C, Coleman, SJ, Commisso, M, Connell, SH, Dalton, MM, Danagoulian, S, Daniel, A, Day, DB, Dhamija, S, Dunne, J, Dutta, D, Ent, R, Gaskell, D, Gasparian, A, Gran, R, Horn, T, Huang, Liting, Huber, GM, Jayalath, C, Johnson, M, Jones, MK, Kalantarians, N, Liyanage, A, Keppel, CE, Kinney, E, Li, Y, Malace, S, Manly, S, Markowitz, P, Maxwell, J, Mbianda, NN, McFarland, KS, Meziane, M, Meziani, ZE, Mills, GB, Mkrtchyan, H, Mkrtchyan, A, Mulholland, J, Nelson, J, Niculescu, G, Niculescu, I, Pentchev, L, Puckett, A, Punjabi, V, Qattan, IA, Reimer, PE, Reinhold, J, Rodriguez, VM, Rondon-Aramayo, O, Sakuda, M, Sakumoto, WK, Segbefia, E, Seva, T, Sick, I, Slifer, K, Smith, GR, Steinman, J, Solvignon, P, Tadevosyan, V, Tajima, S, Tvaskis, V, Vulcan, WF, Walton, T, Wesselmann, FR, Wood, SA, and Ye, Zhihong
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, E06-009 Collaboration, nucl-ex, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract: We present extractions of the nucleon nonsinglet moments utilizing new precision data on the deuteron F_{2} structure function at large Bjorken-x determined via the Rosenbluth separation technique at Jefferson Lab Experimental Hall C. These new data are combined with a complementary set of data on the proton previously measured in Hall C at similar kinematics and world datasets on the proton and deuteron at lower x measured at SLAC and CERN. The new Jefferson Lab data provide coverage of the upper third of the x range, crucial for precision determination of the higher moments. In contrast to previous extractions, these moments have been corrected for nuclear effects in the deuteron using a new global fit to the deuteron and proton data. The obtained experimental moments represent an order of magnitude improvement in precision over previous extractions using high x data. Moreover, recent exciting developments in lattice QCD calculations provide a first ever comparison of these new experimental results with calculations of moments carried out at the physical pion mass, as well as a new approach that first calculates the quark distributions directly before determining moments.
Published: 2019

67. Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina

Author: Judith Lechner, Reinhold J. Medina, Noemi Lois, and Alan W. Stitt
Subjects: Diabetic retinopathy, DME, PDR, Macular ischemia, Microvascular disease, Neurodegeneration, Medicine (General), R5-920, Biochemistry, QD415-436
Abstract: Abstract Background Diabetic retinopathy, a major complication of diabetes mellitus, is a leading cause of sigh-loss in working age adults. Progressive loss of integrity of the retinal neurovascular unit is a central element in the disease pathogenesis. Retinal ischemia and inflammatory processes drive interrelated pathologies such as blood retinal barrier disruption, fluid accumulation, gliosis, neuronal loss and/or aberrant neovascularisation. Current treatment options are somewhat limited to late-stages of the disease where there is already significant damage to the retinal architecture arising from degenerative, edematous and proliferative pathology. New preventive and interventional treatments to target early vasodegenerative and neurodegenerative stages of the disease are needed to ensure avoidance of sight-loss. Main body Historically, diabetic retinopathy has been considered a primarily microvascular disease of the retina and clinically it is classified based on the presence and severity of vascular lesions. It is now known that neurodegeneration plays a significant role during the pathogenesis. Loss of neurons has been documented at early stages in pre-clinical models as well as in individuals with diabetes and, in some, even prior to the onset of clinically overt diabetic retinopathy. Recent studies suggest that some patients have a primarily neurodegenerative phenotype. Retinal pigment epithelial cells and the choroid are also affected during the disease pathogenesis and these tissues may also need to be addressed by new regenerative treatments. Most stem cell research for diabetic retinopathy to date has focused on addressing vasculopathy. Pre-clinical and clinical studies aiming to restore damaged vasculature using vasoactive progenitors including mesenchymal stromal/stem cells, adipose stem cells, CD34+ cells, endothelial colony forming cells and induced pluripotent stem cell derived endothelial cells are discussed in this review. Stem cells that could replace dying neurons such as retinal progenitor cells, pluripotent stem cell derived photoreceptors and ganglion cells as well as Müller stem cells are also discussed. Finally, challenges of stem cell therapies relevant to diabetic retinopathy are considered. Conclusion Stem cell therapies hold great potential to replace dying cells during early and even late stages of diabetic retinopathy. However, due to the presence of different phenotypes, selecting the most suitable stem cell product for individual patients will be crucial for successful treatment.
Published: 2022
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68. Technical supplement to “Polarization transfer observables in elastic electron-proton scattering at Q 2 = 2 . 5 , 5 . 2 , 6 . 8 and 8 . 5 GeV 2 ”

Author: Puckett, AJR, Brash, EJ, Jones, MK, Luo, W, Meziane, M, Pentchev, L, Perdrisat, CF, Punjabi, V, Wesselmann, FR, Afanasev, A, Ahmidouch, A, Albayrak, I, Aniol, KA, Arrington, J, Asaturyan, A, Baghdasaryan, H, Benmokhtar, F, Bertozzi, W, Bimbot, L, Bosted, P, Boeglin, W, Butuceanu, C, Carter, P, Chernenko, S, Christy, ME, Cornejo, JC, Covrig, S, Danagoulian, S, Daniel, A, Davidenko, A, Day, D, Dhamija, S, Dutta, D, Ent, R, Frullani, S, Fenker, H, Frlez, E, Garibaldi, F, Gaskell, D, Gilad, S, Gilman, R, Goncharenko, Y, Hafidi, K, Hamilton, D, Higinbotham, DW, Hinton, W, Horn, T, Hu, B, Huang, J, Huber, GM, Jensen, E, Keppel, C, Khandaker, M, King, P, Kirillov, D, Kohl, M, Kravtsov, V, Kumbartzki, G, Li, Y, Mamyan, V, Margaziotis, DJ, Marsh, A, Matulenko, Y, Maxwell, J, Mbianda, G, Meekins, D, Melnik, Y, Miller, J, Mkrtchyan, A, Mkrtchyan, H, Moffit, B, Moreno, O, Mulholland, J, Narayan, A, Nedev, S, Nuruzzaman, Piasetzky, E, Pierce, W, Piskunov, NM, Prok, Y, Ransome, RD, Razin, DS, Reimer, P, Reinhold, J, Rondon, O, Shabestari, M, Shahinyan, A, Shestermanov, K, Širca, S, Sitnik, I, Smykov, L, Smith, G, Solovyev, L, Solvignon, P, Subedi, R, Tomasi-Gustafsson, E, Vasiliev, A, Veilleux, M, Wojtsekhowski, BB, and Wood, S
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Proton form factors, Magnetic spectrometer, Electromagnetic calorimeter, Proton polarimeter, Polarization transfer method, Spin transport, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Nuclear & Particles Physics, Nuclear and plasma physics
Abstract: The GEp-III and GEp-2γ experiments, carried out in Jefferson Lab's Hall C from 2007–2008, consisted of measurements of polarization transfer in elastic electron–proton scattering at momentum transfers of Q2=2.5,5.2,6.8, and 8.54 GeV 2. These measurements were carried out to improve knowledge of the proton electromagnetic form factor ratio R=μpGEp∕GMp at large values of Q2 and to search for effects beyond the Born approximation in polarization transfer observables at Q2=2.5GeV2. The final results of both experiments were reported in a recent archival publication. A full reanalysis of the data from both experiments was carried out in order to reduce the systematic and, for the GEp-2γ experiment, statistical uncertainties. This technical note provides additional details of the final analysis omitted from the main publication, including the final evaluation of the systematic uncertainties.
Published: 2018

69. Technical supplement to “Polarization transfer observables in elastic electron-proton scattering at Q2=2.5,5.2,6.8 and 8.5GeV2”

Author: Puckett, AJR, Brash, EJ, Jones, MK, Luo, W, Meziane, M, Pentchev, L, Perdrisat, CF, Punjabi, V, Wesselmann, FR, Afanasev, A, Ahmidouch, A, Albayrak, I, Aniol, KA, Arrington, J, Asaturyan, A, Baghdasaryan, H, Benmokhtar, F, Bertozzi, W, Bimbot, L, Bosted, P, Boeglin, W, Butuceanu, C, Carter, P, Chernenko, S, Christy, ME, Cornejo, JC, Covrig, S, Danagoulian, S, Daniel, A, Davidenko, A, Day, D, Dhamija, S, Dutta, D, Ent, R, Frullani, S, Fenker, H, Frlez, E, Garibaldi, F, Gaskell, D, Gilad, S, Gilman, R, Goncharenko, Y, Hafidi, K, Hamilton, D, Higinbotham, DW, Hinton, W, Horn, T, Hu, B, Huang, J, Huber, GM, Jensen, E, Keppel, C, Khandaker, M, King, P, Kirillov, D, Kohl, M, Kravtsov, V, Kumbartzki, G, Li, Y, Mamyan, V, Margaziotis, DJ, Marsh, A, Matulenko, Y, Maxwell, J, Mbianda, G, Meekins, D, Melnik, Y, Miller, J, Mkrtchyan, A, Mkrtchyan, H, Moffit, B, Moreno, O, Mulholland, J, Narayan, A, Nedev, S, Nuruzzaman, Piasetzky, E, Pierce, W, Piskunov, NM, Prok, Y, Ransome, RD, Razin, DS, Reimer, P, Reinhold, J, Rondon, O, Shabestari, M, Shahinyan, A, Shestermanov, K, Širca, S, Sitnik, I, Smykov, L, Smith, G, Solovyev, L, Solvignon, P, Subedi, R, Tomasi-Gustafsson, E, Vasiliev, A, Veilleux, M, Wojtsekhowski, BB, and Wood, S
Subjects: Proton form factors, Magnetic spectrometer, Electromagnetic calorimeter, Proton polarimeter, Polarization transfer method, Spin transport, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences
Abstract: The GEp-III and GEp-2γ experiments, carried out in Jefferson Lab's Hall C from 2007–2008, consisted of measurements of polarization transfer in elastic electron–proton scattering at momentum transfers of Q2=2.5,5.2,6.8, and 8.54 GeV 2. These measurements were carried out to improve knowledge of the proton electromagnetic form factor ratio R=μpGEp∕GMp at large values of Q2 and to search for effects beyond the Born approximation in polarization transfer observables at Q2=2.5GeV2. The final results of both experiments were reported in a recent archival publication. A full reanalysis of the data from both experiments was carried out in order to reduce the systematic and, for the GEp-2γ experiment, statistical uncertainties. This technical note provides additional details of the final analysis omitted from the main publication, including the final evaluation of the systematic uncertainties.
Published: 2018

70. Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina

Author: Lechner, Judith, Medina, Reinhold J., Lois, Noemi, and Stitt, Alan W.
Published: 2022
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71. Design and Performance of the Spin Asymmetries of the Nucleon Experiment

Author: Maxwell, J. D., Armstrong, W. R., Choi, S., Jones, M. K., Kang, H., Liyanage, A., Meziani, Z. -E., Mulholland, J., Ndukum, L., Rondon, O. A., Ahmidouch, A., Albayrak, I., Asaturyan, A., Ates, O., Baghdasaryan, H., Boeglin, W., Bosted, P., Brash, E., Brock, J., Butuceanu, C., Bychkov, M., Carlin, C., Carter, P., Chen, C., Chen, J. -P., Christy, M. E., Covrig, S., Crabb, D., Danagoulian, S., Daniel, A., Davidenko, A. M., Davis, B., Day, D., Deconinck, W., Deur, A., Dunne, J., Dutta, D., Fassi, L. El, Elaasar, M., Ellis, C., Ent, R., Flay, D., Frlez, E., Gaskell, D., Geagla, O., German, J., Gilman, R., Gogami, T., Gomez, J., Goncharenko, Y. M., Hashimoto, O., Higinbotham, D. W., Horn, T., Huber, G. M., Jones, M., Kalantarians, N., Kang, H. K., Kawama, D., Keith, C., Keppel, C., Khandaker, M., Kim, Y., King, P. M., Kohl, M., Kovacs, K., Kubarovsky, V., Li, Y., Liyanage, N., Luo, W., Mamyan, V., Markowitz, P., Maruta, T., Meekins, D., Melnik, Y. M., Mkrtchyan, A., Mkrtchyan, H., Mochalov, V. V., Monaghan, P., Narayan, A., Nakamura, S. N., Nuruzzaman, Pentchev, L., Pocanic, D., Posik, M., Puckett, A., Qiu, X., Reinhold, J., Riordan, S., Roche, J., Sawatzky, B., Shabestari, M., Slifer, K., Smith, G., Soloviev, L., Solvignon, P., Tadevosyan, V., Tang, L., Vasiliev, A. N., Veilleux, M., Walton, T., Wesselmann, F., Wood, S. A., Yao, H., Ye, Z., and Zhu, L.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The Spin Asymmetries of the Nucleon Experiment (SANE) performed inclusive, double-polarized electron scattering measurements of the proton at the Continuous Electron Beam Accelerator Facility at Jefferson Lab. A novel detector array observed scattered electrons of four-momentum transfer $2.5 < Q^2< 6.5$ GeV$^2$ and Bjorken scaling $0.3
Published: 2017
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72. Experimental techniques and performance of $\Lambda$-hypernuclear spectroscopy with the $(e,e^{\prime}K^{+})$ reaction

Author: Gogami, T., Chen, C., Fujii, Y., Hashimoto, O., Kaneta, M., Kawama, D., Maruta, T., Matsumura, A., Nagao, S., Nakamura, S. N., Okayasu, Y., Reinhold, J., Tang, L., Tsukada, K., Wood, S. A., and Yuan, L.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The missing-mass spectroscopy of $\Lambda$ hypernuclei via the $(e,e^{\prime}K^{+})$ reaction has been developed through experiments at JLab Halls A and C in the last two decades. For the latest experiment, E05-115 in Hall C, we developed a new spectrometer system consisting of the HKS and HES; resulting in the best energy resolution ($E_{\Lambda} \simeq0.5$-MeV FWHM) and $B_{\Lambda}$ accuracy ($B_{\Lambda}\leq0.2$ MeV) in $\Lambda$-hypernuclear reaction spectroscopy. This paper describes the characteristics of the $(e,e^{\prime}K^{+})$ reaction compared to other reactions and experimental methods. In addition, the experimental apparatus, some of the important analyses such as the semi-automated calibration of absolute energy scale, and the performance achieved in E05-115 are presented., Comment: 20 pages, 23 figures
Published: 2017
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73. Polarization Transfer Observables in Elastic Electron Proton Scattering at $Q^2 = $2.5, 5.2, 6.8, and 8.5 GeV$^2$

Author: Puckett, A. J. R., Brash, E. J., Jones, M. K., Luo, W., Meziane, M., Pentchev, L., Perdrisat, C. F., Punjabi, V., Wesselmann, F. R., Afanasev, A., Ahmidouch, A., Albayrak, I., Aniol, K. A., Arrington, J., Asaturyan, A., Baghdasaryan, H., Benmokhtar, F., Bertozzi, W., Bimbot, L., Bosted, P., Boeglin, W., Butuceanu, C., Carter, P., Chernenko, S., Christy, E., Commisso, M., Cornejo, J. C., Covrig, S., Danagoulian, S., Daniel, A., Davidenko, A., Day, D., Dhamija, S., Dutta, D., Ent, R., Frullani, S., Fenker, H., Frlez, E., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Goncharenko, Y., Hafidi, K., Hamilton, D., Higinbotham, D. W., Hinton, W., Horn, T., Hu, B., Huang, J., Huber, G. M., Jensen, E., Keppel, C., Khandaker, M., King, P., Kirillov, D., Kohl, M., Kravtsov, V., Kumbartzki, G., Li, Y., Mamyan, V., Margaziotis, D. J., Marsh, A., Matulenko, Y., Maxwell, J., Mbianda, G., Meekins, D., Melnik, Y., Miller, J., Mkrtchyan, A., Mkrtchyan, H., Moffit, B., Moreno, O., Mulholland, J., Narayan, A., Nedev, S., Nuruzzaman, Piasetzky, E., Pierce, W., Piskunov, N. M., Prok, Y., Ransome, R. D., Razin, D. S., Reimer, P., Reinhold, J., Rondon, O., Shabestari, M., Shahinyan, A., Shestermanov, K., Sirca, S., Sitnik, I., Smykov, L., Smith, G., Solovyev, L., Solvignon, P., Subedi, R., Tomasi-Gustafsson, E., Vasiliev, A., Veilleux, M., Wojtsekhowski, B. B., Wood, S., Ye, Z., Zanevsky, Y., Zhang, X., Zhang, Y., Zheng, X., and Zhu, L.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: The GEp-III and GEp-2$\gamma$ experiments were carried out in Jefferson Lab's (JLab's) Hall C from 2007-2008, to extend the knowledge of $G_E^p/G_M^p$ to the highest practically achievable $Q^2$ and to search for effects beyond the Born approximation in polarization transfer observables of elastic $\vec{e}p$ scattering. This article reports an expanded description of the common experimental apparatus and data analysis procedure, and the results of a final reanalysis of the data from both experiments, including the previously unpublished results of the full-acceptance data of the GEp-2$\gamma$ experiment. The Hall C High Momentum Spectrometer detected and measured the polarization of protons recoiling elastically from collisions of JLab's polarized electron beam with a liquid hydrogen target. A large-acceptance electromagnetic calorimeter detected the elastically scattered electrons in coincidence to suppress inelastic backgrounds. The final GEp-III data are largely unchanged relative to the originally published results. The statistical uncertainties of the final GEp-2$\gamma$ data are significantly reduced at $\epsilon = 0.632$ and $0.783$ relative to the original publication. The decrease with $Q^2$ of $G_E^p/G_M^p$ continues to $Q^2 = 8.5$ GeV$^2$, but at a slowing rate relative to the approximately linear decrease observed in earlier Hall A measurements. At $Q^2 = 2.5$ GeV$^2$, the proton form factor ratio $G_E^p/G_M^p$ shows no statistically significant $\epsilon$-dependence, as expected in the Born approximation. The ratio $P_\ell/P_\ell^{Born}$ of the longitudinal polarization transfer component to its Born value shows an enhancement of roughly 1.4\% at $\epsilon = 0.783$ relative to $\epsilon = 0.149$, with $\approx 1.9\sigma$ significance based on the total uncertainty, implying a similar effect in the transverse component $P_t$ that cancels in the ratio $R$., Comment: 44 pages, 28 figures. Archival publication for the GEp-III and GEp-2gamma experiments that ran in Jefferson Lab's experimental Hall C from October, 2007 to June, 2008. v2: final manuscript as accepted by PRC. v3: Replaced figures 13 and 19 with corrected versions from published Erratum. Also made minor corrections to the text and to Table XI reflecting the corrections in the published Erratum
Published: 2017
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74. Technical Supplement to 'Polarization Transfer Observables in Elastic Electron-Proton Scattering at Q$^2$ = 2.5, 5.2, 6.8, and 8.5 GeV$^2$'

Author: Puckett, A. J. R., Brash, E. J., Jones, M. K., Luo, W., Meziane, M., Pentchev, L., Perdrisat, C. F., Punjabi, V., Wesselmann, F. R., Ahmidouch, A., Albayrak, I., Aniol, K. A., Arrington, J., Asaturyan, A., Baghdasaryan, H., Benmokhtar, F., Bertozzi, W., Bimbot, L., Bosted, P., Boeglin, W., Butuceanu, C., Carter, P., Chernenko, S., Christy, E., Commisso, M., Cornejo, J. C., Covrig, S., Danagoulian, S., Daniel, A., Davidenko, A., Day, D., Dhamija, S., Dutta, D., Ent, R., Frullani, S., Fenker, H., Frlez, E., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Goncharenko, Y., Hafidi, K., Hamilton, D., Higinbotham, D. W., Hinton, W., Horn, T., Hu, B., Huang, J., Huber, G. M., Jensen, E., Keppel, C., Khandaker, M., King, P., Kirillov, D., Kohl, M., Kravtsov, V., Kumbartzki, G., Li, Y., Mamyan, V., Margaziotis, D. J., Marsh, A., Matulenko, Y., Maxwell, J., Mbianda, G., Meekins, D., Melnik, Y., Miller, J., Mkrtchyan, A., Mkrtchyan, H., Moffit, B., Moreno, O., Mulholland, J., Narayan, A., Nedev, S., Nurruzzaman, Piasetzky, E., Pierce, W., Piskunov, N. M., Prok, Y., Ransome, R. D., Razin, D. S., Reimer, P., Reinhold, J., Rondon, O., Shabestari, M., Shahinyan, A., Shestermanov, K., Sirca, S., Sitnik, I., Smykov, L., Smith, G., Solovyev, L., Solvignon, P., Subedi, R., Tomasi-Gustafsson, E., Vasiliev, A., Veilleux, M., Wojtsekhowski, B. B., Wood, S., Ye, Z., Zanevsky, Y., Zhang, X., Zhang, Y., Zheng, X., and Zhu, L.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: The GEp-III and GEp-2$\gamma$ experiments, carried out in Jefferson Lab's Hall C from 2007-2008, consisted of measurements of polarization transfer in elastic electron-proton scattering at momentum transfers of $Q^2 = 2.5, 5.2, 6.8,$ and $8.54$ GeV$^2$. These measurements were carried out to improve knowledge of the proton electromagnetic form factor ratio $R = \mu_p G_E^p/G_M^p$ at large values of $Q^2$ and to search for effects beyond the Born approximation in polarization transfer observables at $Q^2 = 2.5$ GeV$^2$. The final results of both experiments were reported in a recent archival publication. A full reanalysis of the data from both experiments was carried out in order to reduce the systematic and, for the GEp-2$\gamma$ experiment, statistical uncertainties. This technical note provides additional details of the final analysis omitted from the main publication, including the final evaluation of the systematic uncertainties., Comment: 33 pages, 33 figures. v3 = Final manuscript as accepted for publication in Nuclear Instruments and Methods Section A (in press)
Published: 2017
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75. Measurement of the beam asymmetry $\Sigma$ for $\pi^0$ and $\eta$ photoproduction on the proton at $E_\gamma = 9$ GeV

Author: GlueX Collaboration, Ghoul, H. Al, Anassontzis, E. G., Austregesilo, A., Barbosa, F., Barnes, A., Beattie, T. D., Bennett, D. W., Berdnikov, V. V., Black, T., Boeglin, W., Briscoe, W. J., Brooks, W. K., Cannon, B. E., Chernyshov, O., Chudakov, E., Crede, V., Dalton, M. M., Deur, A., Dobbs, S., Dolgolenko, A., Dugger, M., Dzhygadlo, R., Egiyan, H., Eugenio, P., Fanelli, C., Foda, A. M., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gerasimov, A., Gevorgyan, N., Goetzen, K., Goryachev, V. S., Guo, L., Hakobyan, H., Hardin, J., Henderson, A., Huber, G. M., Ireland, D. G., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kamel, M., Klein, F. J., Kliemt, R., Kourkoumeli, C., Kuleshov, S., Kuznetsov, I., Lara, M., Larin, I., Lawrence, D., Levine, W. I., Livingston, K., Lolos, G. J., Lyubovitskij, V., Mack, D., Mattione, P. T., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., McIntyre, J., Mendez, R., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mokaya, F., Moriya, K., Nerling, F., Nigmatkulov, G., Ochoa, N., Ostrovidov, A. I., Papandreou, Z., Patsyuk, M., Pedroni, R., Pennington, M. R., Pentchev, L., Peters, K. J., Pooser, E., Pratt, B., Qiang, Y., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Salgado, C., Schumacher, R. A., Schwarz, C., Schwiening, J., Semenov, A. Yu., Semenova, I. A., Seth, K. K., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Sparks, N., Staib, M. J., Stevens, J. R., Strakovsky, I. I., Subedi, A., Tarasov, V., Taylor, S., Teymurazyan, A., Tolstukhin, I., Tomaradze, A., Toro, A., Tsaris, A., Vasileiadis, G., Vega, I., Walford, N. K., Werthmuller, D., Whitlatch, T., Williams, M., Wolin, E., Xiao, T., Zarling, J., Zhang, Z., Zihlmann, B., Mathieu, V., and Nys, J.
Subjects: Nuclear Experiment
Abstract: We report measurements of the photon beam asymmetry $\Sigma$ for the reactions $\vec{\gamma}p\to p\pi^0$ and $\vec{\gamma}p\to p\eta $ from the GlueX experiment using a 9 GeV linearly-polarized, tagged photon beam incident on a liquid hydrogen target in Jefferson Lab's Hall D. The asymmetries, measured as a function of the proton momentum transfer, possess greater precision than previous $\pi^0$ measurements and are the first $\eta$ measurements in this energy regime. The results are compared with theoretical predictions based on $t$-channel, quasi-particle exchange and constrain the axial-vector component of the neutral meson production mechanism in these models., Comment: 6 pages, 6 figures, Published in Physical Review C: Rapid Communication
Published: 2017
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76. Modulation of diabetes-related retinal pathophysiology by PTX3.

Author: Pathak, Varun, Bertelli, Pietro M., Pedrini, Edoardo, Harkin, Kevin, Peixoto, Elisa, Allen, Lynsey-Dawn, Mcloughlin, Kiran, Chavda, Natasha D., Hamill, Kevin J., Guduric-Fuchs, Jasenka, Inforzato, Antonio, Bottazzi, Barbara, Stitt, Alan W., and Medina, Reinhold J.
Subjects: VISION, DIABETIC retinopathy, DIABETES complications, DISEASE progression, TISSUE remodeling
Abstract: Diabetic retinopathy (DR) is a common complication of diabetes characterized by vascular pathology and neuroinflammation. Pentraxin 3 (PTX3) is a soluble pattern recognition molecule that functions at the crossroads between innate immunity, inflammation, and tissue remodeling. DR is known to involve inflammatory pathways, although the potential relevance of PTX3 has not been explored. We found that PTX3 protein levels increased in the retina of diabetic mice. Similarly, evaluation of a publicly available transcriptomic human dataset revealed increased PTX3 expression in DR with diabetic macular edema and proliferative retinopathy, when compared to nondiabetic retinas or diabetic retinas without complications. To further understand the role of PTX3 within DR, we employed the streptozotocin-induced diabetes model in PTX3 knockout mice (PTX3KO), which were followed up for 9 mo to evaluate hallmarks of disease progression. In diabetic PTX3KO mice, we observed decreased reactive gliosis, diminished microglia activation, and reduced vasodegeneration, when compared to diabetic PTX3 wild-type littermates. The decrease in DR-associated pathological features in PTX3KO retinas translated into preserved visual function, as evidenced by improved optokinetic response, restored b-wave amplitude in electroretinograms, and attenuated neurodegeneration. We showed that PTX3 induced an inflammatory phenotype in human retinal macroglia, characterized by GFAP upregulation and increased secretion of IL6 and PAI-1. We confirmed that PTX3 was required for TNF-α-induced reactive gliosis, as PTX3KO retinal explants did not up-regulate GFAP in response to TNF-α. This study reveals a unique role for PTX3 as an enhancer of sterile inflammation in DR, which drives pathogenesis and ultimately visual impairment. [ABSTRACT FROM AUTHOR]
Published: 2024
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77. A new gene signature for endothelial senescence identifies self‐RNA sensing by retinoic acid‐inducible gene I as a molecular facilitator of vascular aging.

Author: Guduric‐Fuchs, Jasenka, Pedrini, Edoardo, Bertelli, Pietro M., McDonnell, Shannon, Pathak, Varun, McLoughlin, Kiran, O'Neill, Christina L., Stitt, Alan W., and Medina, Reinhold J.
Subjects: VASCULAR endothelial cells, ENDOTHELIAL cells, DNA damage, PHENOTYPES, CARDIOVASCULAR diseases
Abstract: The number of senescent vascular endothelial cells increases during aging and their dysfunctional phenotype contributes to age‐related cardiovascular disease. Identification of senescent cells is challenging as molecular changes are often tissue specific and occur amongst clusters of normal cells. Here, we established, benchmarked, and validated a new gene signature called EndoSEN that pinpoints senescent endothelial cells. The EndoSEN signature was enriched for interferon‐stimulated genes (ISG) and correlated with the senescence‐associated secretory phenotype (SASP). SASP establishment is classically attributed to DNA damage and cyclic GMP–AMP synthase activation, but our results revealed a pivotal role for RNA accumulation and sensing in senescent endothelial cells. Mechanistically, we showed that endothelial cell senescence hallmarks include self‐RNA accumulation, RNA sensor RIG‐I upregulation, and an ISG signature. Moreover, a virtual model of RIG‐I knockout in endothelial cells underscored senescence as a key pathway regulated by this sensor. We tested and confirmed that RIG‐I knockdown was sufficient to extend the lifespan and decrease the SASP in endothelial cells. Taken together, our evidence suggests that targeting RNA sensing is a potential strategy to delay vascular aging. [ABSTRACT FROM AUTHOR]
Published: 2024
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78. PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia

Author: Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, and David J. Grieve
Subjects: NOX4 NADPH oxidase, placenta-specific 8, endothelial colony-forming cells, hypoxia, angiogenesis, reactive oxygen species, Cytology, QH573-671
Abstract: Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential due to their enhanced angiogenic and proliferative capacity, their impaired functionality within the disease microenvironment represents a major barrier to clinical translation. The aim of this study was to define the specific contribution of NOX4 NADPH oxidase, which we previously reported as a key CB-ECFC regulator, to hypoxia-induced dysfunction and its potential as a therapeutic target. CB-ECFCs exposed to experimental hypoxia demonstrated downregulation of NOX4-mediated reactive oxygen species (ROS) signalling linked with a reduced tube formation, which was partially restored by NOX4 plasmid overexpression. siRNA knockdown of placenta-specific 8 (PLAC8), identified by microarray analysis as an upstream regulator of NOX4 in hypoxic versus normoxic CB-ECFCs, enhanced tube formation, NOX4 expression and hydrogen peroxide generation, and induced several key transcription factors associated with downstream Nrf2 signalling. Taken together, these findings indicated that activation of the PLAC8–NOX4 signalling axis improved CB-ECFC angiogenic functions in experimental hypoxia, highlighting this pathway as a potential target for protecting therapeutic cells against the ischaemic cardiovascular disease microenvironment.
Published: 2023
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79. Erratum: Polarization transfer observables in elastic electron-proton scattering at Q2=2.5, 5.2, 6.8, and 8.5 GeV2 (Physical Review C (2017) 96 (055203) DOI: 10.1103/PhysRevC.96.055203)

Author: Puckett, AJR, Brash, EJ, Jones, MK, Luo, W, Meziane, M, Pentchev, L, Perdrisat, CF, Punjabi, V, Wesselmann, FR, Afanasev, A, Ahmidouch, A, Albayrak, I, Aniol, KA, Arrington, J, Asaturyan, A, Baghdasaryan, H, Benmokhtar, F, Bertozzi, W, Bimbot, L, Bosted, P, Boeglin, W, Butuceanu, C, Carter, P, Chernenko, S, Christy, ME, Commisso, M, Cornejo, JC, Covrig, S, Danagoulian, S, Daniel, A, Davidenko, A, Day, D, Dhamija, S, Dutta, D, Ent, R, Frullani, S, Fenker, H, Frlez, E, Garibaldi, F, Gaskell, D, Gilad, S, Gilman, R, Goncharenko, Y, Hafidi, K, Hamilton, D, Higinbotham, DW, Hinton, W, Horn, T, Hu, B, Huang, J, Huber, GM, Jensen, E, Keppel, C, Khandaker, M, King, P, Kirillov, D, Kohl, M, Kravtsov, V, Kumbartzki, G, Li, Y, Mamyan, V, Margaziotis, DJ, Marsh, A, Matulenko, Y, Maxwell, J, Mbianda, G, Meekins, D, Melnik, Y, Miller, J, Mkrtchyan, A, Mkrtchyan, H, Moffit, B, Moreno, O, Mulholland, J, Narayan, A, Nedev, S, Nuruzzaman, Piasetzky, E, Pierce, W, Piskunov, NM, Prok, Y, Ransome, RD, Razin, DS, Reimer, P, Reinhold, J, Rondon, O, Shabestari, M, Shahinyan, A, Shestermanov, K, Širca, S, Sitnik, I, Smykov, L, Smith, G, Solovyev, L, Solvignon, P, Subedi, R, Tomasi-Gustafsson, E, Vasiliev, A, Veilleux, M, and Wojtsekhowski, BB
Abstract: Subsequent to the release of our original paper, we discovered in the context of preparing our technical supplement [1] for journal publication that a typographical error had existed in the text file that the analysis program used to construct the beam polarization "database" for both the original analysis, published in Ref. [2], and our final analysis. The electron-beam polarization P e and the analyzing power A y cancel exactly in the ratio R , which is proportional to the ratio P t / P l of the transferred polarization components. On the other hand, the extraction of the relative e dependence of P l / P Born l relies on knowledge of the beam polarization. As such, data taking was interrupted roughly every two days during the GEp - 2 ? experiment to perform invasive measurements of the beam polarization using the Hall C Moller polarimeter [3]. The run range affected by the typographical error was entirely contained within the data collected at Q 2 = 2.5 GeV 2 with a beam energy of E e = 3.680 GeV during January 2008. The data from this configuration were combined with the data collected at E e = 3.548 GeV due to the nearly complete overlap of these two settings in terms of Q 2 and e acceptance. It is worth remarking that this typographical error went unnoticed for so long because it only affected a small fraction of the data (less than half of the combined data for ? e ? = 0.790 ) and the difference between the actually assigned beam polarization and the polarization that should have been assigned was comparable in magnitude to the point-to-point systematic uncertainty of the measurement itself. As such, its effect did not show up in various diagnostic plots and statistical tests, such as the time stability of the extracted P l / P Born l ratio. The data for both E e = 3.548 and E e = 3.680 GeV were reprocessed using the corrected beam polarizations to determine the effect of the typographical error on the combined physics results at ? e ? = 0.790 . Because the value of P e cancels in the ratio R , changes in the assumed beam polarization can only affect the results for R via statistical fluctuations due to changes in the relative weighting of different run ranges in the unbinned maximum-likelihood estimators for R . These effects are negligible on the scale of both the statistical and the systematic uncertainties of the data. More noticeable changes are expected in the ratio P l / P Born l since the extracted value of P l is inversely proportional to the assumed value of P e . Table I shows the effect of the corrected beam polarization database on the polarization transfer observables for the combined data for the ? e ? = 0.790 setting, the only measurement affected by the typographical error. The analyzing power did not need to be recalibrated since it was determined using the ? e ? = 0.153 data, which were not affected by the typographical error. As expected, the change in the ratio R is negligible. The value of P Born l , which is computed event by event from the global fit described in the Appendix of the original paper and does not depend on P e , is also unchanged. The magnitudes of P t , P l , and P l / P Born l are reduced by a common multiplicative factor, reflecting the fact that the beam polarization had been underestimated for the run range affected by the typographical error. The most important result of the corrected analysis is that the ratio P l / P Born l has decreased by 0.0024 from 1.0167 to 1.0143, a change comparable in magnitude to the statistical uncertainty but small compared to the total and point-to-point systematic uncertainties. The P l / P Born l result for the original publication [2] would be reduced by the same multiplicative factor as the final result. The physics conclusions of both publications are not materially changed by this correction. (Table Presented). (Figure Presented).
Published: 2018

80. Erratum: Polarization transfer observables in elastic electron-proton scattering at Q2=2.5, 5.2, 6.8, and 8.5GeV2 [Phys. Rev. C 96, 055203 (2017)]

Author: Puckett, AJR, Brash, EJ, Jones, MK, Luo, W, Meziane, M, Pentchev, L, Perdrisat, CF, Punjabi, V, Wesselmann, FR, Afanasev, A, Ahmidouch, A, Albayrak, I, Aniol, KA, Arrington, J, Asaturyan, A, Baghdasaryan, H, Benmokhtar, F, Bertozzi, W, Bimbot, L, Bosted, P, Boeglin, W, Butuceanu, C, Carter, P, Chernenko, S, Christy, ME, Commisso, M, Cornejo, JC, Covrig, S, Danagoulian, S, Daniel, A, Davidenko, A, Day, D, Dhamija, S, Dutta, D, Ent, R, Frullani, S, Fenker, H, Frlez, E, Garibaldi, F, Gaskell, D, Gilad, S, Gilman, R, Goncharenko, Y, Hafidi, K, Hamilton, D, Higinbotham, DW, Hinton, W, Horn, T, Hu, B, Huang, J, Huber, GM, Jensen, E, Keppel, C, Khandaker, M, King, P, Kirillov, D, Kohl, M, Kravtsov, V, Kumbartzki, G, Li, Y, Mamyan, V, Margaziotis, DJ, Marsh, A, Matulenko, Y, Maxwell, J, Mbianda, G, Meekins, D, Melnik, Y, Miller, J, Mkrtchyan, A, Mkrtchyan, H, Moffit, B, Moreno, O, Mulholland, J, Narayan, A, Nedev, S, Nuruzzaman, Piasetzky, E, Pierce, W, Piskunov, NM, Prok, Y, Ransome, RD, Razin, DS, Reimer, P, Reinhold, J, Rondon, O, Shabestari, M, Shahinyan, A, Shestermanov, K, Širca, S, Sitnik, I, Smykov, L, Smith, G, Solovyev, L, Solvignon, P, Subedi, R, Tomasi-Gustafsson, E, Vasiliev, A, Veilleux, M, and Wojtsekhowski, BB
Subjects: Physical Sciences, Classical Physics, Nuclear and plasma physics
Abstract: Subsequent to the release of our original paper, we discovered in the context of preparing our technical supplement [1] for journal publication that a typographical error had existed in the text file that the analysis program used to construct the beam polarization "database" for both the original analysis, published in Ref. [2], and our final analysis. The electron-beam polarization P e and the analyzing power A y cancel exactly in the ratio R , which is proportional to the ratio P t / P l of the transferred polarization components. On the other hand, the extraction of the relative e dependence of P l / P Born l relies on knowledge of the beam polarization. As such, data taking was interrupted roughly every two days during the GEp - 2 ? experiment to perform invasive measurements of the beam polarization using the Hall C Moller polarimeter [3]. The run range affected by the typographical error was entirely contained within the data collected at Q 2 = 2.5 GeV 2 with a beam energy of E e = 3.680 GeV during January 2008. The data from this configuration were combined with the data collected at E e = 3.548 GeV due to the nearly complete overlap of these two settings in terms of Q 2 and e acceptance. It is worth remarking that this typographical error went unnoticed for so long because it only affected a small fraction of the data (less than half of the combined data for ? e ? = 0.790 ) and the difference between the actually assigned beam polarization and the polarization that should have been assigned was comparable in magnitude to the point-to-point systematic uncertainty of the measurement itself. As such, its effect did not show up in various diagnostic plots and statistical tests, such as the time stability of the extracted P l / P Born l ratio. The data for both E e = 3.548 and E e = 3.680 GeV were reprocessed using the corrected beam polarizations to determine the effect of the typographical error on the combined physics results at ? e ? = 0.790 . Because the value of P e cancels in the ratio R , changes in the assumed beam polarization can only affect the results for R via statistical fluctuations due to changes in the relative weighting of different run ranges in the unbinned maximum-likelihood estimators for R . These effects are negligible on the scale of both the statistical and the systematic uncertainties of the data. More noticeable changes are expected in the ratio P l / P Born l since the extracted value of P l is inversely proportional to the assumed value of P e . Table I shows the effect of the corrected beam polarization database on the polarization transfer observables for the combined data for the ? e ? = 0.790 setting, the only measurement affected by the typographical error. The analyzing power did not need to be recalibrated since it was determined using the ? e ? = 0.153 data, which were not affected by the typographical error. As expected, the change in the ratio R is negligible. The value of P Born l , which is computed event by event from the global fit described in the Appendix of the original paper and does not depend on P e , is also unchanged. The magnitudes of P t , P l , and P l / P Born l are reduced by a common multiplicative factor, reflecting the fact that the beam polarization had been underestimated for the run range affected by the typographical error. The most important result of the corrected analysis is that the ratio P l / P Born l has decreased by 0.0024 from 1.0167 to 1.0143, a change comparable in magnitude to the statistical uncertainty but small compared to the total and point-to-point systematic uncertainties. The P l / P Born l result for the original publication [2] would be reduced by the same multiplicative factor as the final result. The physics conclusions of both publications are not materially changed by this correction. (Table Presented). (Figure Presented).
Published: 2018

81. Measurements of the separated longitudinal structure function FL from hydrogen and deuterium targets at low Q2

Author: Tvaskis, V, Tvaskis, A, Niculescu, I, Abbott, D, Adams, GS, Afanasev, A, Ahmidouch, A, Angelescu, T, Arrington, J, Asaturyan, R, Avery, S, Baker, OK, Benmouna, N, Berman, BL, Biselli, A, Blok, HP, Boeglin, WU, Bosted, PE, Brash, E, Breuer, H, Chang, G, Chant, N, Christy, ME, Connell, SH, Dalton, MM, Danagoulian, S, Day, D, Dodario, T, Dunne, JA, Dutta, D, El Khayari, N, Ent, R, Fenker, HC, Frolov, VV, Gaskell, D, Garrow, K, Gilman, R, Gueye, P, Hafidi, K, Hinton, W, Holt, RJ, Horn, T, Huber, GM, Jackson, H, Jiang, X, Jones, MK, Joo, K, Kelly, JJ, Keppel, CE, Kuhn, J, Kinney, E, Klein, A, Kubarovsky, V, Liang, Y, Lolos, G, Lung, A, Mack, D, Malace, S, Markowitz, P, Mbianda, G, McGrath, E, McKee, D, Meekins, DG, Mkrtchyan, H, Napolitano, J, Navasardyan, T, Niculescu, G, Nozar, M, Ostapenko, T, Papandreou, Z, Potterveld, D, Reimer, PE, Reinhold, J, Roche, J, Rock, SE, Schulte, E, Segbefia, E, Smith, C, Smith, GR, Stoler, P, Tadevosyan, V, Tang, L, Telfeyan, J, Todor, L, Ungaro, M, Uzzle, A, Vidakovic, S, Villano, A, Vulcan, WF, Warren, G, Wesselmann, F, Wojtsekhowski, B, Wood, SA, Yan, C, and Zihlmann, B
Abstract: Structure functions, as measured in lepton-nucleon scattering, have proven to be very useful in studying the partonic dynamics within the nucleon. However, it is experimentally difficult to separately determine the longitudinal and transverse structure functions, and consequently there are substantially less data available in particular for the longitudinal structure function. Here, we present separated structure functions for hydrogen and deuterium at low four-momentum transfer squared, Q2
Published: 2018

82. Separated kaon electroproduction cross section and the kaon form factor from 6 GeV JLab data

Author: Carmignotto, M, Ali, S, Aniol, K, Arrington, J, Barrett, B, Beise, EJ, Blok, HP, Boeglin, W, Brash, EJ, Breuer, H, Chang, CC, Christy, ME, Dittmann, A, Ent, R, Fenker, H, Gaskell, D, Gibson, E, Holt, RJ, Horn, T, Huber, GM, Jin, S, Jones, MK, Keppel, CE, Kim, W, King, PM, Kovaltchouk, V, Liu, J, Lolos, GJ, MacK, DJ, Margaziotis, DJ, Markowitz, P, Matsumura, A, Meekins, D, Miyoshi, T, Mkrtchyan, H, Niculescu, G, Niculescu, I, Okayasu, Y, Pegg, IL, Pentchev, L, Perdrisat, C, Potterveld, D, Punjabi, V, Reimer, PE, Reinhold, J, Roche, J, Sarty, A, Smith, GR, Tadevosyan, V, Tang, LG, Trotta, R, Tvaskis, V, Vargas, A, Vidakovic, S, Volmer, J, Vulcan, W, Warren, G, Wood, SA, Xu, C, and Zheng, X
Subjects: nucl-ex
Abstract: The H1(e,e′K+)Λ reaction was studied as a function of the Mandelstam variable -t using data from the E01-004 (FPI-2) and E93-018 experiments that were carried out in Hall C at the 6 GeV Jefferson Laboratory. The cross section was fully separated into longitudinal and transverse components, and two interference terms at four-momentum transfers Q2 of 1.00, 1.36, and 2.07GeV2. The kaon form factor was extracted from the longitudinal cross section using the Regge model by Vanderhaeghen et al. [Phys. Rev. C 57, 1454 (1998)PRVCAN0556-281310.1103/PhysRevC.57.1454]. The results establish the method, previously used successfully for pion analyses, for extracting the kaon form factor. Data from 12 GeV Jefferson Laboratory experiments are expected to have sufficient precision to distinguish between theoretical predictions, for example, recent perturbative QCD calculations with modern parton distribution amplitudes. The leading-twist behavior for light mesons is predicted to set in for values of Q2 between 5 and 10GeV2, which makes data in the few-GeV regime particularly interesting. The Q2 dependence at fixed x and -t of the longitudinal cross section that we extracted seems consistent with the QCD factorization prediction within the experimental uncertainty.
Published: 2018

83. Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina

Author: Marzena Kurzawa‐Akanbi, Phillip Whitfield, Florence Burté, Pietro Maria Bertelli, Varun Pathak, Mary Doherty, Birthe Hilgen, Lina Gliaudelytė, Mark Platt, Rachel Queen, Jonathan Coxhead, Andrew Porter, Maria Öberg, Daniela Fabrikova, Tracey Davey, Chia Shyan Beh, Maria Georgiou, Joseph Collin, Veronika Boczonadi, Anetta Härtlova, Michael Taggart, Jumana Al‐Aama, Viktor I Korolchuk, Christopher M Morris, Jasenka Guduric‐Fuchs, David H Steel, Reinhold J Medina, Lyle Armstrong, and Majlinda Lako
Subjects: age‐related macular degeneration, complement factor H, extracellular vesicles, human induced pluripotent stem cells, retinal pigment epithelium, photoreceptors, Cytology, QH573-671
Abstract: Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient‐specific RPE cells with the Complement Factor H Y402H high‐risk polymorphism to perform a comprehensive analysis of extracellular vesicles (EVs), their cargo and role in disease pathology. We show that AMD RPE is characterised by enhanced polarised EV secretion. Multi‐omics analyses demonstrate that AMD RPE EVs carry RNA, proteins and lipids, which mediate key AMD features including oxidative stress, cytoskeletal dysfunction, angiogenesis and drusen accumulation. Moreover, AMD RPE EVs induce amyloid fibril formation, revealing their role in drusen formation. We demonstrate that exposure of control RPE to AMD RPE apical EVs leads to the acquisition of AMD features such as stress vacuoles, cytoskeletal destabilization and abnormalities in the morphology of the nucleus. Retinal organoid treatment with apical AMD RPE EVs leads to disrupted neuroepithelium and the appearance of cytoprotective alpha B crystallin immunopositive cells, with some co‐expressing retinal progenitor cell markers Pax6/Vsx2, suggesting injury‐induced regenerative pathways activation. These findings indicate that AMD RPE EVs are potent inducers of AMD phenotype in the neighbouring RPE and retinal cells.
Published: 2022
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84. BS38 Dna methylation proteins regulate endothelial colony-forming cell angiogenic dysfunction in hypoxia

Author: Madishetti, Vinuthna Vani, primary, Pun, Shun Hay, additional, Pedrini, Edoardo, additional, Medina, Reinhold J, additional, Grieve, David J, additional, and O’Neill, Karla M, additional
Published: 2024
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85. BS43 Hyperglycaemia induces epigenetic dysregulation in human endothelial colony-forming cells which limits their vasoreparative and therapeutic potential

Author: O’Neill, Karla M, primary, Madishetti, Vinuthna Vani, additional, Edgar, Kevin, additional, Pedrini, Edoardo, additional, McLoughlin, Kiran J, additional, Pun, Shun Hay, additional, O’Neill, Christina, additional, Guduric-Fuchs, Jasenka, additional, Medina, Reinhold J, additional, Jurkowski, Tomasz, additional, Walsh, Colum P, additional, and Grieve, David J, additional
Published: 2024
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86. The Aerogel Cherenkov Detector for the SHMS magnetic spectrometer in Hall C at Jefferson Lab

Author: Horn, T., Mkrtchyan, H., Ali, S., Asaturyan, A., Carmignotto, M. A. P., Dittmann, A., Dutta, D., Ent, R., Hlavin, N., Illieva, Y., Mkrtchyan, A., Nadel-Turonski, P., Pegg, I. L., Ramos, A., Reinhold, J., Sapkota, I., Tadevosyan, V., Zhamkochyan, S., and Wood, S. A.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: Hadronic reactions producing strange quarks such as exclusive or semi-inclusive kaon production, play an important role in studies of hadron structure and the dynamics that bind the most basic elements of nuclear physics. The small-angle capability of the new Super High Momentum Spectrometer (SHMS) in Hall C, coupled with its high momentum reach - up to the anticipated 11-GeV beam energy in Hall C - and coincidence capability with the well-understood High Momentum Spectrometer, will allow for probes of such hadron structure involving strangeness down to the smallest distance scales to date. To cleanly select the kaons, a threshold aerogel Cerenkov detector has been constructed for the SHMS. The detector consists of an aerogel tray followed by a diffusion box. Four trays for aerogel of nominal refractive indices of n=1.030, 1.020, 1.015 and 1.011 were constructed. The tray combination will allow for identification of kaons from 1 GeV/c up to 7.2 GeV/c, reaching 10^-2 proton and 10^-3 pion rejection, with kaon detection efficiency better than 95%. The diffusion box of the detector is equipped with 14 five-inch diameter photomultiplier tubes. Its interior walls are covered with Gore diffusive reflector, which is superior to the commonly used Millipore paper and improved the detector performance by 35%. The inner surface of the two aerogel trays with higher refractive index is covered with Millipore paper, however, those two trays with lower aerogel refractive index are again covered with Gore diffusive reflector for higher performance. The measured mean number of photoelectrons in saturation is ~12 for n=1.030, ~sim8 for n=1.020, ~10 for n=1.015, and ~5.5 for n=1.011. The design details, the results of component characterization, and initial performance tests and optimization of the detector are presented.
Published: 2016
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87. Spectroscopy of the neutron-rich hypernucleus $^{7}_{\Lambda}$He from electron scattering

Author: Gogami, T., Chen, C., Kawama, D., Achenbach, P., Ahmidouch, A., Albayrak, I., Androic, D., Asaturyan, A., Asaturyan, R., Ates, O., Baturin, P., Badui, R., Boeglin, W., Bono, J., Brash, E., Carter, P., Chiba, A., Christy, E., Danagoulian, S., De Leo, R., Doi, D., Elaasar, M., Ent, R., Fujii, Y., Fujita, M., Furic, M., Gabrielyan, M., Gan, L., Garibaldi, F., Gaskell, D., Gasparian, A., Han, Y., Hashimoto, O., Horn, T., Hu, B., Hungerford, Ed. V., Jones, M., Kanda, H., Kaneta, M., Kato, S., Kawai, M., Khanal, H., Kohl, M., Liyanage, A., Luo, W., Maeda, K., Margaryan, A., Markowitz, P., Maruta, T., Matsumura, A., Maxwell, V., Mkrtchyan, A., Mkrtchyan, H., Nagao, S., Nakamura, S. N., Narayan, A., Neville, C., Niculescu, G., Niculescu, M. I., Nunez, A., Nuruzzaman, Okayasu, Y., Petkovic, T., Pochodzalla, J., Qiu, X., Reinhold, J., Rodriguez, V. M., Samanta, C., Sawatzky, B., Seva, T., Shichijo, A., Tadevosyan, V., Tang, L., Taniya, N., Tsukada, K., Veilleux, M., Vulcan, W., Wesselmann, F. R., Wood, S. A., Yamamoto, T., Ya, L., Ye, Z., Yokota, K., Yuan, L., Zhamkochyan, S., and Zhu, L.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: The missing mass spectroscopy of the $^{7}_{\Lambda}$He hypernucleus was performed, using the $^{7}$Li$(e,e^{\prime}K^{+})^{7}_{\Lambda}$He reaction at the Thomas Jefferson National Accelerator Facility Hall C. The $\Lambda$ binding energy of the ground state (1/2$^{+}$) was determined with a smaller error than that of the previous measurement, being $B_{\Lambda}$ = 5.55 $\pm$ 0.10(stat.) $\pm$ 0.11(sys.) MeV. The experiment also provided new insight into charge symmetry breaking in p-shell hypernuclear systems. Finally, a peak at $B_{\Lambda}$ = 3.65 $\pm$ 0.20(stat.) $\pm$ 0.11(sys.) MeV was observed and assigned as a mixture of 3/2$^{+}$ and 5/2$^{+}$ states, confirming the "gluelike" behavior of $\Lambda$, which makes an unstable state in $^{6}$He stable against neutron emission., Comment: 6 pages, 4 figures
Published: 2016
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88. Measurements of the Separated Longitudinal Structure Function F_L from Hydrogen and Deuterium Targets at Low Q^2

Author: Tvaskis, V., Tvaskis, A., Niculescu, I., Abbott, D., Adams, G. S., Afanasev, A., Ahmidouch, A., Angelescu, T., Arrington, J., Asaturyan, R., Avery, S., Baker, O. K., Benmouna, N., Berman, B. L., Biselli, A., Blok, H. P., Boeglin, W. U., Bosted, P. E., Brash, E., Breuer, H., Chang, G., Chant, N., Christy, M. E., Connell, S. H., Dalton, M. M., Danagoulian, S., Day, D., Dodario, T., Dunne, J. A., Dutta, D., Khayari, N. El, Ent, R., Fenker, H. C., Frolov, V. V., Gaskell, D., Garrow, K., Gilman, R., Gueye, P., Hafidi, K., Hinton, W., Holt, R. J., Horn, T., Huber, G. M., Jackson, H., Jiang, X., Jones, M. K., Joo, K., Kelly, J. J., Keppel, C. E., Kuhn, J., Kinney, E., Klein, A., Kubarovsky, V., Liang, M., Liang, Y., Lolos, G., Lung, A., Mack, D., Malace, S., Markowitz, P., Mbianda, G., McGrath, E., Mckee, D., McKee, P., Meekins, D. G., Mkrtchyan, H., Moziak, B., Napolitano, J., Navasardyan, T., Niculescu, G., Nozar, M., Ostapenko, T., Papandreou, Z., Potterveld, D., Reimer, P. E., Reinhold, J., Roche, J., Rock, S. E., Schulte, E., Segbefia, E., Smith, C., Smith, G. R., Stoler, P., Tadevosyan, V., Tang, L., Telfeyan, J., Todor, L., Ungaro, M., Uzzle, A., Vidakovic, S., Villano, A., Vulcan, W. F., Wang, M., Warren, G., Wesselmann, F., Wojtsekhowski, B., Wood, S. A., Xu, C., Yan, C., Yuan, L., Zheng, X., Zihlmann, B., and Zhu, H.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: Structure functions, as measured in lepton-nucleon scattering, have proven to be very useful in studying the quark dynamics within the nucleon. However, it is experimentally difficult to separately determine the longitudinal and transverse structure functions, and consequently there are substantially less data available for the longitudinal structure function in particular. Here we present separated structure functions for hydrogen and deuterium at low four--momentum transfer squared, Q^2< 1 GeV^2, and compare these with parton distribution parameterizations and a k_T factorization approach. While differences are found, the parameterizations generally agree with the data even at the very low Q^2 scale of the data. The deuterium data show a smaller longitudinal structure function, and smaller ratio of longitudinal to transverse cross section R, than the proton. This suggests either an unexpected difference in R for the proton and neutron or a suppression of the gluonic distribution in nuclei., Comment: 11 pages, 7 figures, 2 data tables
Published: 2016
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89. First Results from The GlueX Experiment

Author: The GlueX Collaboration, Ghoul, H. Al, Anassontzis, E. G., Barbosa, F., Barnes, A., Beattie, T. D., Bennett, D. W., Berdnikov, V. V., Black, T., Boeglin, W., Brooks, W. K., Cannon, B., Chernyshov, O., Chudakov, E., Crede, V., Dalton, M. M., Deur, A., Dobbs, S., Dolgolenko, A., Dugger, M., Egiyan, H., Eugenio, P., Foda, A. M., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gerasimov, A., Gevorgyan, N., Goryachev, V. S., Guegan, B., Guo, L., Hakobyan, H., Hakobyan2, H., Hardin, J., Huber, G. M., Ireland, D., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kamel, M., Klein, F. J., Kourkoumeli, C., Kuleshov, S., Lara, M., Larin, I., Lawrence, D., Leckey, J., Levine, W. I., Livingston, K., Lolos, G. J., Mack, D., Mattione, P. T., Matveev, V., McCaughan, M., McGinley, W., McIntyre, J., Mendez, R., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mokaya, F., Moriya, K., Nigmatkulov, G., Ochoa, N., Ostrovidov, A. I., Papandreou, Z., Pedroni, R., Pennington, M., Pentchev, L., Ponosov, A., Pooser, E., Pratt, B., Qiang, Y., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Salgado, C., Schumacher, R. A., Semenov, A. Yu., Semenova, I. A., Senderovich, I., Seth, K. K., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Sparks, N., Staib, M. J., Stevens, J. R., Subedi, A., Tarasov, V., Taylor, S., Tolstukhin, I., Tomaradze, A., Toro, A., Tsaris, A., Vasileiadis, G., Vega, I., Voulgaris, G., Walford, N. K., Whitlatch, T., Williams, M., Wolin, E., Xiao, T., Zarling, J., and Zihlmann, B.
Subjects: Nuclear Experiment, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The GlueX experiment at Jefferson Lab ran with its first commissioning beam in late 2014 and the spring of 2015. Data were collected on both plastic and liquid hydrogen targets, and much of the detector has been commissioned. All of the detector systems are now performing at or near design specifications and events are being fully reconstructed, including exclusive production of $\pi^{0}$, $\eta$ and $\omega$ mesons. Linearly-polarized photons were successfully produced through coherent bremsstrahlung and polarization transfer to the $\rho$ has been observed., Comment: 8 pages, 6 figures, Invited contribution to the Hadron 2015 Conference, Newport News VA, September 2015
Published: 2015
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90. miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

Author: Guduric-Fuchs, Jasenka, Pedrini, Edoardo, Lechner, Judith, Chambers, Sarah E.J., O’Neill, Christina L., Mendes Lopes de Melo, Joana, Pathak, Varun, Church, Rachel H., McKeown, Stuart, Bojdo, James, Mcloughlin, Kiran J., Stitt, Alan W., and Medina, Reinhold J.
Published: 2021
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91. Polarization transfer observables in elastic electron-proton scattering at Q2=2.5, 5.2, 6.8, and 8.5 GeV2 POLARIZATION TRANSFER OBSERVABLES in ELASTIC ... A. J. R. PUCKETT et al.

Author: Puckett, AJR, Brash, EJ, Jones, MK, Luo, W, Meziane, M, Pentchev, L, Perdrisat, CF, Punjabi, V, Wesselmann, FR, Afanasev, A, Ahmidouch, A, Albayrak, I, Aniol, KA, Arrington, J, Asaturyan, A, Baghdasaryan, H, Benmokhtar, F, Bertozzi, W, Bimbot, L, Bosted, P, Boeglin, W, Butuceanu, C, Carter, P, Chernenko, S, Christy, ME, Commisso, M, Cornejo, JC, Covrig, S, Danagoulian, S, Daniel, A, Davidenko, A, Day, D, Dhamija, S, Dutta, D, Ent, R, Frullani, S, Fenker, H, Frlez, E, Garibaldi, F, Gaskell, D, Gilad, S, Gilman, R, Goncharenko, Y, Hafidi, K, Hamilton, D, Higinbotham, DW, Hinton, W, Horn, T, Hu, B, Huang, J, Huber, GM, Jensen, E, Keppel, C, Khandaker, M, King, P, Kirillov, D, Kohl, M, Kravtsov, V, Kumbartzki, G, Li, Y, Mamyan, V, Margaziotis, DJ, Marsh, A, Matulenko, Y, Maxwell, J, Mbianda, G, Meekins, D, Melnik, Y, Miller, J, Mkrtchyan, A, Mkrtchyan, H, Moffit, B, Moreno, O, Mulholland, J, Narayan, A, Nedev, S, Nuruzzaman, Piasetzky, E, Pierce, W, Piskunov, NM, Prok, Y, Ransome, RD, Razin, DS, Reimer, P, Reinhold, J, Rondon, O, Shabestari, M, Shahinyan, A, Shestermanov, K, Širca, S, Sitnik, I, Smykov, L, Smith, G, Solovyev, L, Solvignon, P, Subedi, R, Tomasi-Gustafsson, E, Vasiliev, A, Veilleux, M, and Wojtsekhowski, BB
Abstract: Background: Interest in the behavior of nucleon electromagnetic form factors at large momentum transfers has steadily increased since the discovery, using polarization observables, of the rapid decrease of the ratio GEp/GMp of the proton's electric and magnetic form factors for momentum transfers Q21 GeV2, in strong disagreement with previous extractions of this ratio using the traditional Rosenbluth separation technique. Purpose: The GEp-III and GEp-2γ experiments were carried out in Jefferson Laboratory's (JLab's) Hall C from 2007 to 2008, to extend the knowledge of GEp/GMp to the highest practically achievable Q2 given the maximum beam energy of 6 GeV and to search for effects beyond the Born approximation in polarization transfer observables of elastic ∫ - p scattering. This article provides an expanded description of the common experimental apparatus and data analysis procedures, and reports the results of a final reanalysis of the data from both experiments, including the previously unpublished results of the full-acceptance dataset of the GEp-2γ experiment. Methods: Polarization transfer observables in elastic ∫ - p→∫ - scattering were measured at central Q2 values of 2.5, 5.2, 6.8, and 8.54 GeV2. At Q2=2.5GeV2, data were obtained for central values of the virtual photon polarization parameter ϵ of 0.149, 0.632, and 0.783. The Hall C High Momentum Spectrometer detected and measured the polarization of protons recoiling elastically from collisions of JLab's polarized electron beam with a liquid hydrogen target. A large-acceptance electromagnetic calorimeter detected the elastically scattered electrons in coincidence to suppress inelastic backgrounds. Results: The final GEp-III data are largely unchanged relative to the originally published results. The statistical uncertainties of the final GEp-2γ data are significantly reduced at ϵ=0.632 and 0.783 relative to the original publication. Conclusions: The final GEp-III results show that the decrease with Q2 of GEp/GMp continues to Q2=8.5GeV2, but at a slowing rate relative to the approximately linear decrease observed in earlier Hall A measurements. At Q2=8.5GeV2, GEp/GMp remains positive but is consistent with zero. At Q2=2.5GeV2, GEp/GMp derived from the polarization component ratio R-Pt/P shows no statistically significant ϵ dependence, as expected in the Born approximation. On the other hand, the ratio P""/P""Born of the longitudinal polarization transfer component to its Born value shows an enhancement of roughly 1.7% at ϵ=0.783 relative to ϵ=0.149, with ≈2.2σ significance based on the total uncertainty, implying a similar effect in the transverse component Pt that cancels in the ratio R.
Published: 2017

92. The GlueX beamline and detector

Author: Adhikari, S., Akondi, C.S., Al Ghoul, H., Ali, A., Amaryan, M., Anassontzis, E.G., Austregesilo, A., Barbosa, F., Barlow, J., Barnes, A., Barriga, E., Barsotti, R., Beattie, T.D., Benesch, J., Berdnikov, V.V., Biallas, G., Black, T., Boeglin, W., Brindza, P., Briscoe, W.J., Britton, T., Brock, J., Brooks, W.K., Cannon, B.E., Carlin, C., Carman, D.S., Carstens, T., Cao, N., Chernyshov, O., Chudakov, E., Cole, S., Cortes, O., Crahen, W.D., Crede, V., Dalton, M.M., Daniels, T., Deur, A., Dickover, C., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Dzierba, A., Egiyan, H., Erbora, T., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Foda, A.M., Foote, J., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gerasimov, A., Gevorgyan, N., Gleason, C., Goetzen, K., Goncalves, A., Goryachev, V.S., Guo, L., Hakobyan, H., Hamdi, A., Hardin, J., Henschel, C.L., Huber, G.M., Hutton, C., Hurley, A., Ioannou, P., Ireland, D.G., Ito, M.M., Jarvis, N.S., Jones, R.T., Kakoyan, V., Katsaganis, S., Kalicy, G., Kamel, M., Keith, C.D., Klein, F.J., Kliemt, R., Kolybaba, D., Kourkoumelis, C., Krueger, S.T., Kuleshov, S., Larin, I., Lawrence, D., Leckey, J.P., Lersch, D.I., Leverington, B.D., Levine, W.I., Li, W., Liu, B., Livingston, K., Lolos, G.J., Lyubovitskij, V., Mack, D., Marukyan, H., Mattione, P.T., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., McIntyre, J., Meekins, D., Mendez, R., Meyer, C.A., Miskimen, R., Mitchell, R.E., Mokaya, F., Moriya, K., Nerling, F., Ng, L., Ni, H., Ostrovidov, A.I., Papandreou, Z., Patsyuk, M., Paudel, C., Pauli, P., Pedroni, R., Pentchev, L., Peters, K.J., Phelps, W., Pierce, J., Pooser, E., Popov, V., Pratt, B., Qiang, Y., Qin, N., Razmyslovich, V., Reinhold, J., Ritchie, B.G., Ritman, J., Robison, L., Romanov, D., Romero, C., Salgado, C., Sandoval, N., Satogata, T., Schertz, A.M., Schadmand, S., Schick, A., Schumacher, R.A., Schwarz, C., Schwiening, J., Semenov, A.Yu., Semenova, I.A., Seth, K.K., Shen, X., Shepherd, M.R., Smith, E.S., Sober, D.I., Somov, A., Somov, S., Soto, O., Sparks, N., Staib, M.J., Stanislav, C., Stevens, J.R., Stewart, J., Strakovsky, I.I., Sumner, B.C. L., Suresh, K., Tarasov, V.V., Taylor, S., Teigrob, L.A., Teymurazyan, A., Thiel, A., Tolstukhin, I., Tomaradze, A., Toro, A., Tsaris, A., Van Haarlem, Y., Vasileiadis, G., Vega, I., Visser, G., Voulgaris, G., Walford, N.K., Werthmüller, D., Whitlatch, T., Wickramaarachchi, N., Williams, M., Wolin, E., Xiao, T., Yang, Y., Zarling, J., Zhang, Z., Zhou, Q., Zhou, X., and Zihlmann, B.
Published: 2021
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93. Long term high glucose exposure induces premature senescence in retinal endothelial cells

Author: Pietro Maria Bertelli, Edoardo Pedrini, David Hughes, Shannon McDonnell, Varun Pathak, Elisa Peixoto, Jasenka Guduric-Fuchs, Alan W Stitt, and Reinhold J. Medina
Subjects: diabetic retina, senescence, retinal microvasculature, diabetic retina complications, vascular biology, senescence-associated secretory phenotype, Physiology, QP1-981
Abstract: Purpose: Features of cellular senescence have been described in diabetic retinal vasculature. The aim of this study was to investigate how the high glucose microenvironment impacts on the senescence program of retinal endothelial cells.Methods: Human retinal microvascular endothelial cells were cultured under control and high glucose conditions of 5 mM and 25 mM D-glucose, respectively. Isomeric l-glucose was used as the osmotic control. Cells were counted using CASY technology until they reached their Hayflick limit. Senescence-associated β-Galactosidase was used to identify senescent cells. Endothelial cell functionality was evaluated by the clonogenic, 3D tube formation, and barrier formation assays. Cell metabolism was characterized using the Seahorse Bioanalyzer. Gene expression analysis was performed by bulk RNA sequencing. Retinal tissues from db/db and db/+ mice were evaluated for the presence of senescent cells. Publicly available scRNA-sequencing data for retinas from Akimba and control mice was used for gene set enrichment analysis.Results: Long term exposure to 25 mM D-Glucose accelerated the establishment of cellular senescence in human retinal endothelial cells when compared to 5 mM D-glucose and osmotic controls. This was shown from 4 weeks, by a significant slower growth, higher percentages of cells positive for senescence-associated β-galactosidase, an increase in cell size, and lower expression of pRb and HMGB2. These senescence features were associated with decreased clonogenic capacity, diminished tubulogenicity, and impaired barrier function. Long term high glucose-cultured cells exhibited diminished glycolysis, with lower protein expression of GLUT1, GLUT3, and PFKFB3. Transcriptomic analysis, after 4 weeks of culture, identified downregulation of ALDOC, PFKL, and TPI1, in cells cultured with 25 mM D-glucose when compared to controls. The retina from db/db mice showed a significant increase in acellular capillaries associated with a significant decrease in vascular density in the intermediate and deep retinal plexuses, when compared to db/+ mice. Senescent endothelial cells within the db/db retinal vasculature were identified by senescence-associated β-galactosidase staining. Analysis of single cell transcriptomics data for the Akimba mouse retina highlighted an enrichment of senescence and senescence-associated secretory phenotype gene signatures when compared to control mice.Conclusion: A diabetic-like microenvironment of 25 mM D-glucose was sufficient to accelerate the establishment of cellular senescence in human retinal microvascular endothelial cells.
Published: 2022
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94. High Resolution Spectroscopic Study of $^{10}_{\Lambda}$Be

Author: Gogami, T., Chen, C., Kawama, D., Achenbach, P., Ahmidouch, A., Albayrak, I., Androic, D., Asaturyan, A., Asaturyan, R., Ates, O., Baturin, P., Badui, R., Boeglin, W., Bono, J., Brash, E., Carter, P., Chiba, A., Christy, E., Danagoulian, S., De Leo, R., Doi, D., Elaasar, M., Ent, R., Fujii, Y., Fujita, M., Furic, M., Gabrielyan, M., Gan, L., Garibaldi, F., Gaskell, D., Gasparian, A., Han, Y., Hashimoto, O., Horn, T., Hu, B., Hungerford, Ed. V., Jones, M., Kanda, H., Kaneta, M., Kato, S., Kawai, M., Khanal, H., Kohl, M., Liyanage, A., Luo, W., Maeda, K., Margaryan, A., Markowitz, P., Maruta, T., Matsumura, A., Maxwell, V., Mkrtchyan, A., Mkrtchyan, H., Nagao, S., Nakamura, S. N., Narayan, A., Neville, C., Niculescu, G., Niculescu, M. I., Nunez, A., Nuruzzaman, Okayasu, Y., Petkovic, T., Pochodzalla, J., Qiu, X., Reinhold, J., Rodriguez, V. M., Samanta, C., Sawatzky, B., Seva, T., Shichijo, A., Tadevosyan, V., Tang, L., Taniya, N., Tsukada, K., Veilleux, M., Vulcan, W., Wesselmann, F. R., Wood, S. A., Yamamoto, T., Ya, L., Ye, Z., Yokota, K., Yuan, L., Zhamkochyan, S., and Zhu, L.
Subjects: Nuclear Experiment
Abstract: Spectroscopy of a $^{10}_{\Lambda}$Be hypernucleus was carried out at JLab Hall C using the $(e,e^{\prime}K^{+})$ reaction. A new magnetic spectrometer system (SPL+HES+HKS), specifically designed for high resolution hypernuclear spectroscopy, was used to obtain an energy spectrum with a resolution of 0.78 MeV (FWHM). The well-calibrated spectrometer system of the present experiment using the $p(e,e^{\prime}K^{+})\Lambda,\Sigma^{0}$ reactions allowed us to determine the energy levels, and the binding energy of the ground state peak (mixture of 1$^{-}$ and 2$^{-}$ states) was obtained to be B$_{\Lambda}$=8.55$\pm$0.07(stat.)$\pm$0.11(sys.) MeV. The result indicates that the ground state energy is shallower than that of an emulsion study by about 0.5 MeV which provides valuable experimental information on charge symmetry breaking effect in the $\Lambda N$ interaction., Comment: 6 figures
Published: 2015
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95. Observation of Lambda H-4 hyperhydrogen by decay-pion spectroscopy in electron scattering

Author: Esser, A., Nagao, S., Schulz, F., Achenbach, P., Gayoso, C. Ayerbe, Böhm, R., Borodina, O., Bosnar, D., Bozkurt, V., Debenjak, L., Distler, M. O., Friščić, I., Fujii, Y., Gogami, T., Hashimoto, O., Hirose, S., Kanda, H., Kaneta, M., Kim, E., Kohl, Y., Kusaka, J., Margaryan, A., Merkel, H., Mihovilovič, M., Müller, U., Nakamura, S. N., Pochodzalla, J., Rappold, C., Reinhold, J., Saito, T. R., Lorente, A. Sanchez, Majos, S. Sánchez, Schlimme, B. S., Schoth, M., Sfienti, C., Širca, S., Tang, L., Thiel, M., Tsukada, K., Weber, A., and Yoshida, K.
Subjects: Nuclear Experiment
Abstract: At the Mainz Microtron MAMI, the first high-resolution pion spectroscopy from decays of strange systems was performed by electron scattering off a Be-9 target in order to study the ground-state masses of Lambda-hypernuclei. Positively charged kaons were detected by a short-orbit spectrometer with a broad momentum acceptance at zero degree forward angles with respect to the beam, efficiently tagging the production of strangeness in the target nucleus. In coincidence, negatively charged decay-pions were detected by two independent high-resolution spectrometers. About 10^3 pionic weak decays of hyperfragments and hyperons were observed. The pion momentum distribution shows a monochromatic peak at p_pi ~ 133 MeV/c, corresponding to the unique signature for the two-body decay of hyperhydrogen Lambda H-4 -> He-4 + pi-, stopped inside the target. Its binding energy was determined to be B_Lambda = 2.12 +- 0.01 (stat.) +- 0.09 (syst.) MeV with respect to the H-3 + Lambda mass.
Published: 2015
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96. miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

Author: Jasenka Guduric-Fuchs, Edoardo Pedrini, Judith Lechner, Sarah E.J. Chambers, Christina L. O’Neill, Joana Mendes Lopes de Melo, Varun Pathak, Rachel H. Church, Stuart McKeown, James Bojdo, Kiran J. Mcloughlin, Alan W. Stitt, and Reinhold J. Medina
Subjects: vascular repair, miRNA, hypoxia, angiogenesis, endothelial progenitor, ECFC, Therapeutics. Pharmacology, RM1-950
Abstract: Hypoxia modulates reparative angiogenesis, which is a tightly regulated pathophysiological process. MicroRNAs (miRNAs) are important regulators of gene expression in hypoxia and angiogenesis. However, we do not yet have a clear understanding of how hypoxia-induced miRNAs fine-tune vasoreparative processes. Here, we identify miR-130a as a mediator of the hypoxic response in human primary endothelial colony-forming cells (ECFCs), a well-characterized subtype of endothelial progenitors. Under hypoxic conditions of 1% O2, miR-130a gain-of-function enhances ECFC pro-angiogenic capacity in vitro and potentiates their vasoreparative properties in vivo. Mechanistically, miR-130a orchestrates upregulation of VEGFR2, activation of STAT3, and accumulation of HIF1α via translational inhibition of Ddx6. These findings unveil a new role for miR-130a in hypoxia, whereby it activates the VEGFR2/STAT3/HIF1α axis to enhance the vasoregenerative capacity of ECFCs.
Published: 2021
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97. Separated Response Functions in Exclusive, Forward $\pi^{\pm}$ Electroproduction on Deuterium

Author: Huber, G. M., Blok, H. P., Butuceanu, C., Gaskell, D., Horn, T., Mack, D. J., Abbott, D., Aniol, K., Anklin, H., Armstrong, C., Arrington, J., Assamagan, K., Avery, S., Baker, O. K., Barrett, B., Beise, E. J., Bochna, C., Boeglin, W., Brash, E. J., Breuer, H., Chang, C. C., Chant, N., Christy, M. E., Dunne, J., Eden, T., Ent, R., Fenker, H., Gibson, E. F., Gilman, R., Gustafsson, K., Hinton, W., Holt, R. J., Jackson, H., Jin, S., Jones, M. K., Keppel, C. E., Kim, P. H., Kim, W., King, P. M., Klein, A., Koltenuk, D., Kovaltchouk, V., Liang, M., Liu, J., Lolos, G. J., Lung, A., Margaziotis, D. J., Markowitz, P., Matsumura, A., McKee, D., Meekins, D., Mitchell, J., Miyoshi, T., Mkrtchyan, H., Mueller, B., Niculescu, G., Niculescu, I., Okayasu, Y., Pentchev, L., Perdrisat, C., Pitz, D., Potterveld, D., Punjabi, V., Qin, L. M., Reimer, P. E., Reinhold, J., Roche, J., Roos, P. G., Sarty, A., Shin, I. K., Smith, G. R., Stepanyan, S., Tang, L. G., Tadevosyan, V., Tvaskis, V., van der Meer, R. L. J., Vansyoc, K., Van Westrum, D., Vidakovic, S., Volmer, J., Vulcan, W., Warren, G., Wood, S. A., Xu, C., Yan, C., Zhao, W. -X., Zheng, X., Zihlmann, B., and Collaboration, The Jefferson Lab Fpi
Subjects: Nuclear Experiment
Abstract: Background: Measurements of forward exclusive meson production at different squared four-momenta of the exchanged virtual photon, $Q^2$, and at different four-momentum transfer, t, can be used to probe QCD's transition from meson-nucleon degrees of freedom at long distances to quark-gluon degrees of freedom at short scales. Ratios of separated response functions in $\pi^-$ and $\pi^+$ electroproduction are particularly informative. The ratio for transverse photons may allow this transition to be more easily observed, while the ratio for longitudinal photons provides a crucial verification of the assumed pole dominance, needed for reliable extraction of the pion form factor from electroproduction data. Method: Data were acquired with 2.6-5.2 GeV electron beams and the HMS+SOS spectrometers in Jefferson Lab Hall C, at central $Q^2$ values of 0.6, 1.0, 1.6 GeV$^2$ at W=1.95 GeV, and $Q^2$=2.45 GeV$^2$ at W=2.22 GeV. There was significant coverage in $\phi$ and $\epsilon$, which allowed separation of $\sigma_{L,T,LT,TT}$. Results: $\sigma_L$ shows a clear signature of the pion pole, with a sharp rise at small -t. In contrast, $\sigma_T$ is much flatter versus t. The longitudinal/transverse ratios evolve with $Q^2$ and t, and at the highest $Q^2$=2.45 GeV$^2$ show a slight enhancement for $\pi^-$ production compared to $\pi^+$. The $\pi^-/\pi^+$ ratio for transverse photons exhibits only a small $Q^2$-dependence, following a nearly universal curve with t, with a steep transition to a value of about 0.25, consistent with s-channel quark knockout. The $\sigma_{TT}/\sigma_T$ ratio also drops rapidly with $Q^2$, qualitatively consistent with s-channel helicity conservation. The $\pi^-/\pi^+$ ratio for longitudinal photons indicates a small isoscalar contamination at W=1.95 GeV, consistent with what was observed in our earlier determination of the pion form factor at these kinematics., Comment: 25 pages, 16 figures, 6 tables
Published: 2014
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98. Study of the nnΛΛn State and nnΛΛn Interaction at Jefferson Lab

Author: Itabashi, K., Akiyama, T., Fujii, Y., Fujiwara, T., Garibaldi, F., Gogami, T., Kaneta, M., Katayama, K., Markowitz, P. E. C., Maeda, K., Mizuno, M., Nagao, S., Nakamura, S. N., Nakamura, Y. R., Okuyama, K., Pandey, B., Reinhold, J., Suzuki, K. N., Tang, L., Toyama, Y., Toyoda, T., Uehara, K., Umezaki, E., and Urciuoli, G. M.
Published: 2022
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99. Deuteron Electro-Disintegration at Very High Missing Momenta

Author: Boeglin, W. U., Jones, M. K., Aniol, K., Asaturyan, A., Baghdasaryan, H., Benmokhtar, F., Bitao, H., Danagoulian, S., Day, D., Gaskell, D., Higinbotham, D., Huber, G., Jeschonnek, S., Kalantarians, N., Markowitz, P. E., Mkrtchyan, A., Mkrtchyan, H., Piasetzky, E., Puckett, A., Raue, B. A., Reinhold, J., Ron, G., Sargsian, M., Shneor, R., Smith, G., Subedi, R., Tadevosyan, V., Van Orden, J. W., and Wesselmann, F. R.
Subjects: Nuclear Experiment
Abstract: We propose to measure the D(e,e'p) cross section at $Q^2 = 4.25$ (GeV/c)$^2$ and $x_{bj} = 1.35$ for missing momenta ranging from $p_m = 0.5$ GeV/c to $p_m = 1.0$ GeV/c expanding the range of missing momenta explored in the Hall A experiment (E01-020). At these energy and momentum transfers, calculations based on the eikonal approximation have been shown to be valid and recent experiments indicated that final state interactions are relatively small and possibly independent of missing momenta. This experiment will provide for the first time data in this kinematic regime which are of fundamental importance to the study of short range correlations and high density fluctuations in nuclei. The proposed experiment could serve as a commissioning experiment of the new SHMS together with the HMS in Hall C. A total beam time of 21 days is requested.
Published: 2014

100. A study of decays to strange final states with GlueX in Hall D using components of the BaBar DIRC

Author: The GlueX Collaboration, Dugger, M., Ritchie, B., Senderovich, I., Anassontzis, E., Ioannou, P., Kourkoumeli, C., Vasileiadis, G., Voulgaris, G., Jarvis, N., Levine, W., Mattione, P., McGinley, W., Meyer, C. A., Schumacher, R., Staib, M., Klein, F., Sober, D., Sparks, N., Walford, N., Doughty, D., Barnes, A., Jones, R., McIntyre, J., Mokaya, F., Pratt, B., Boeglin, W., Guo, L., Pooser, E., Reinhold, J., Ghoul, H. Al, Crede, V., Eugenio, P., Ostrovidov, A., Tsaris, A., Ireland, D., Livingston, K., Bennett, D., Bennett, J., Frye, J., Lara, M., Leckey, J., Mitchell, R., Moriya, K., Shepherd, M. R., Chernyshov, O., Dolgolenko, A., Gerasimov, A., Goryachev, V., Larin, I., Matveev, V., Tarasov, V., Barbosa, F., Chudakov, E., Dalton, M., Deur, A., Dudek, J., Egiyan, H., Furletov, S., Ito, M., Mack, D., Lawrence, D., McCaughan, M., Pennington, M., Pentchev, L., Qiang, Y., Smith, E., Somov, A., Taylor, S., Whitlatch, T., Zihlmann, B., Miskimen, R., Guegan, B., Hardin, J., Stevens, J., Williams, M., Berdnikov, V., Nigmatkulov, G., Ponosov, A., Romanov, D., Somov, S., Tolstukhin, I., Salgado, C., Ambrozewicz, P., Gasparian, A., Pedroni, R., Black, T., Gan, L., Dobbs, S., Seth, K., Ting, X., Tomaradze, A., Beattie, T., Huber, G., Lolos, G., Papandreou, Z., Semenov, A., Semenova, I., Brooks, W., Hakobyan, H., Kuleshov, S., Soto, O., Toro, A., Vega, I., Gevorgyan, N., and Kakoyan, V.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: We propose to enhance the kaon identification capabilities of the GlueX detector by constructing an FDIRC (Focusing Detection of Internally Reflected Cherenkov) detector utilizing the decommissioned BaBar DIRC components. The GlueX FDIRC would significantly enhance the GlueX physics program by allowing one to search for and study hybrid mesons decaying into kaon final states. Such systematic studies of kaon final states are essential for inferring the quark flavor content of hybrid and conventional mesons. The GlueX FDIRC would reuse one-third of the synthetic fused silica bars that were utilized in the BaBar DIRC. A new focussing photon camera, read out with large area photodetectors, would be developed. We propose operating the enhanced GlueX detector in Hall D for a total of 220 days at an average intensity of 5x10^7 {\gamma}/s, a program that was conditionally approved by PAC39, Comment: 25 pages, 29 figures
Published: 2014

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