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54. Functional Benefit of Smoking Cessation and Triple Inhaler in Combustible Cigarette Smokers with Severe COPD: A Retrospective Study.

Author

Pezzuto, Aldo, Tonini, Giuseppe, Ciccozzi, Massimo, Crucitti, Pierfilippo, D'Ascanio, Michela, Cosci, Fiammetta, Tammaro, Antonella, Di Sotto, Antonella, Palermo, Teresa, Carico, Elisabetta, and Ricci, Alberto

Subjects
SMOKING cessation, CIGARETTE smokers, INHALERS, CHRONIC obstructive pulmonary disease
Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is the third cause of mortality and it is smoking-related. It is characterized by a non-reversible airflow limitation and a progressive worsening of the respiratory function. Objective: The aim of this study is to point out the benefit of smoking cessation combined with a single inhaler triple therapy in terms of clinical and functional outcome in this setting. Methods: A retrospective analysis was performed in patients affected by severe COPD and at least one exacerbation a year, who underwent a smoking cessation program. All patients underwent a 6 min walking test, body plethysmography, and an exhaled test for carbon monoxide. The modified medical research council test (mMRC) test, the Fagestrom nicotine dependency test (FTND) and the COPD assessment test (CAT) questionnaire were also administered. All patients were checked at the baseline and in the six-month follow-up after the start of the treatment. Results: Smoking cessation was achieved by 51% of patients within a month and it was confirmed by eCO measure (<7 ppm). Patients who quit smoking reported better results after six months compared with patients who did not. The increase in FEV1 within the group of quitters was 90 mL (p < 0.05) and the walking test improved by 90 m (p < 0.01); eCO decreased by 15 ppm (p < 0.01) while FVC increased by 70 mL (p < 0.05). No significant changes were recorded within the group of sustainers. The difference in functional changes between groups was significant with regard to FEV1, cCO, and WT. Conclusions: Smoking cessation enhances the efficacy of single inhaler triple therapy, improving clinical and functional variables after six months from the start. [ABSTRACT FROM AUTHOR]

Published
2023
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55. Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients.

Author

D'Ascanio, Michela, Viccaro, Fausta, Pizzirusso, Dario, Guerrieri, Giulio, Pagliuca, Alessandra, Guerrini, Simone, Innammorato, Marta, De Vitis, Claudia, Raffa, Salvatore, Pezzuto, Aldo, and Ricci, Alberto

Subjects
BLOOD proteins, CHRONIC obstructive pulmonary disease, SURFACE active agents, ENZYME-linked immunosorbent assay, BIOMARKERS
Abstract

Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the relationship between surfactant protein B (Sp-B) serum levels and clinical, radiological, and functional pulmonary parameters in COPD patients. Methods: Forty COPD patients and twenty smokers without airflow limitations or respiratory symptoms were enrolled. Each patient was given questionnaires (CAT and mMRC) and 6MWT, spirometry, DLCO, and computer tomography (CT) were performed. All participants underwent a venous blood sample drawing, and quantitative detection of their Sp-B plasma levels was performed by an enzyme-linked immunosorbent assay. The spirometry and Sp-B plasma levels were assessed after 12 months. Results: A statistically significant difference was found in the plasma Sp-B levels between COPD patients compared to the other group (4.72 + 3.2 ng/mL vs. 1.78 + 1.5 ng/mL; p < 0.001). The change in FEV1 after 12 months (Delta FEV1) showed a significantly negative correlation with respect to the change in Sp-B levels (Delta SpB) (r = −0.4; p < 0.05). This correlation indicates that increasing the plasma dosage of SpB is a foretoken of functional decline. Conclusions: SpB may be considered as a useful marker in COPD assessment and provides prognostic information on lung functional decline. Despite its usefulness, further studies are needed to define its reliability as a biomarker. [ABSTRACT FROM AUTHOR]

Published
2023
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58. Late Breaking Abstract - The TRITRIAL COPD study: preliminary baseline patient characteristics collected during the COVID-19 pandemic

Author

Schino, Pietro, primary, Bargagli, Elena, additional, Ricci, Alberto, additional, Marchesani, Francesca, additional, Pennisi, Alfio, additional, Camiciottoli, Anna, additional, Rocca, Alberto, additional, D'Amato, Mariella, additional, Macagno, Francesco, additional, Ingrassia, Eleonora, additional, Scaffidi Argentina, Ulrica, additional, Piraino, Alessio, additional, and Richeldi, Luca, additional

Published
2021
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64. Multi-omics approach to analyze the molecular pato-physiology of the low T3 syndrome, observed in COVID-19 patients

Author

Sciacchitano, Salvatore, primary, Vitis, Claudia De, additional, D’Ascanio, Michela, additional, Petrucca, Andrea, additional, Salerno, Gerardo, additional, Amodeo, Rachele, additional, Sacconi, Andrea, additional, Salvati, Valentina, additional, Piaggio, Giulia, additional, Latouliere, Luisa de, additional, Ricci, Alberto, additional, and Mancini, Rita, additional

Published
2021
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65. Assessing Static Lung Hyperinflation by Whole-Body Plethysmography, Helium Dilution, and Impulse Oscillometry System (IOS) in Patients with COPD

Author

D'Ascanio, Michela, Viccaro, Fausta, Calabrò, Noemi, Guerrieri, Giulio, Salvucci, Claudia, Pizzirusso, Dario, Mancini, Rita, De Vitis, Claudia, Pezzuto, Aldo, and Ricci, Alberto

Subjects
IOS, International Journal of Chronic Obstructive Pulmonary Disease, Helium, hyperinflation, COPD, Plethysmography, Pulmonary Disease, Chronic Obstructive, Forced Expiratory Volume, Oscillometry, Quality of Life, Humans, Lung, Original Research
Abstract

Michela D’Ascanio,1 Fausta Viccaro,1 Noemi Calabrò,1 Giulio Guerrieri,1 Claudia Salvucci,1 Dario Pizzirusso,1 Rita Mancini,1 Claudia De Vitis,1 Aldo Pezzuto,2 Alberto Ricci1 1Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2Department of Cardiovascular and Respiratory Sciences, Sant’Andrea Hospital, Rome, ItalyCorrespondence: Michela D’Ascanio Via di Grottarossa 1035/1039, Roma 00189, RM, ItalyTel +390633776768Email dascaniomichela87@gmail.comPurpose: Lung hyperinflation is a feature of chronic obstructive pulmonary disease (COPD) and can determine pivotal consequence on symptoms, exercise tolerance and quality of life. Despite the relevance of assessing lung hyperinflation, there is still no single consensus as to what volume should be taken into account. We investigate which spirometric measurement is more reliable in assessing static lung hyperinflation and which is more related with impulse oscillometry system (IOS) measurements in COPD.Patients and Methods: Fifty-five COPD patients were enrolled. TLC, RV and RV:TLC ratio were obtained both with helium and plethysmography techniques. IOS measurements (X5, Fres and R5-R20) were performed. Pearson and Spearman correlation determined the relationships between the functional parameters that evaluate static hyperinflation (RV: TLC, TLC, RV) and IOS measurements.Results: As expected, we reported a statistically significant difference between these two techniques in terms of mean percentage values of TLC (7.57 ± 3.26 L; p= 0.02) and RV (15.24 ± 7.51 L; p=0.04), while RV:TLC measured with the two methods was similar (5.21 ± 4.69%; p=0.27). The correlation analysis showed that IOS parameters, such as difference in resistance between 5 Hz and 20 Hz (R(5– 20)) and resonant frequency (Fres), were positively correlated with RV:TLC ratio, while reactance at 5 Hz (X(5)) was negatively correlated with it. In particular, we pointed out a weak correlation between RV:TLC (%) (Pleth) and R(5– 20) (r=0.3, p=0.04), Fres (r=0.3; p=0.03), while X5 had a mild correlation with RV:TLC (%) (r=− 0.5;p< 0.0001). Moreover, we noticed a strong relationship between RV:TLC (%)(He) and X5 (r=− 0.7; p=0.0001) and a mild correlation between RV:TLC (%) (He) and Fres (r=0.4; p=0.003). Between R5-R20 and RV:TLC, there was a weak correlation (r=0.3; p=0.001). No correlation between TLC, RV (L,%) (both helium and Pleth derived) and IOS parameters (R(5– 20), X5, Fres) was found.Conclusion: RV:TLC can represent the most reliable parameter in the assessment of hyperinflation, considering the absence of significant difference in its measurement between the two techniques. IOS provides supplementary information in the assessment of static hyperinflation.Keywords: hyperinflation, COPD, IOS

Published
2020

71. Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

Author

Scozzi, Davide, primary, Cano, Marlene, additional, Ma, Lina, additional, Zhou, Dequan, additional, Zhu, Ji Hong, additional, O’Halloran, Jane A., additional, Goss, Charles W., additional, Rauseo, Adriana M., additional, Liu, Zhiyi, additional, Sahu, Sanjaya Kumar, additional, Peritore, Valentina, additional, Rocco, Monica, additional, Ricci, Alberto, additional, Amodeo, Rachele, additional, Aimati, Laura, additional, Ibrahim, Mohsen, additional, Hachem, Ramsey R., additional, Kreisel, Daniel, additional, Mudd, Philip A., additional, Kulkarni, Hrishikesh S., additional, and Gelman, Andrew E., additional

Published
2021
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72. Age is not the only risk factor in COVID-19: the role of comorbidities and of long staying in residential care homes.&nbsp;

Author

D'Ascanio, Michela, primary, Innammorato, Marta, additional, Pasquariello, Lara, additional, Pizzirusso, Dario, additional, Guerrieri, Giulio, additional, Castelli, Silvia, additional, Pezzuto, Aldo, additional, De Vitis, Claudia, additional, Anibaldi, Paolo, additional, Marcolongo, Adriano, additional, Mancini, Rita, additional, Ricci, Alberto, additional, and Sciacchitano, Salvatore, additional

Published
2021
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73. Higher blood eosinophil levels after omalizumab treatment may be associated with poorer asthma outcomes

Author

Sposato, B., Migliorini, M.G., Di Tomassi, M., Olivieri, C., Perrella, A., Camiciottoli, G., Maselli, R., Pelaia, G., Busceti, M.T., Sabato, E., Cagnazzo, M.G., Colombo, F., Palumbo, L., Ravazzi, A., Bucca, C., Caiaffa, M.F., Berra, A., Calabrese, C., Stanziola, A.A., Schino, P., Di Gioacchino, M., Rogliani, P., Cazzola, M., Segreti, A., Pastorello, E.A., Scibilia, G., Vianello, A., Marchi, M.R., Paladini, L., Baglioni, S., Abbritti, M., Almerigogna, F., Matucci, A., Vultaggio, A., Maggi, E., Maestrelli, P., Guarnieri, G., Steinhilber, G., Bonavia, M., Rottoli, P., Bargagli, E., Senna, G., Caminati, M., Macchia, L., Bellia, V., Scichilone, N., Paggiaro, P., Novelli, F., Latorre, M., Vergura, L., Masieri, S., Scalese, M., Rosati, Y., Milanese, M., Folletti, I., Pio, R., Pio, A., Maccari, U., Maggiorelli, C., Scala, R., Vignale, L., Pulerà, N., Carpagnano, G.E., Foschino Barbaro, M.P., Sposato, Bruno, Scalese, Marco, Milanese, Manlio, Masieri, Simonetta, Cavaliere, Carlo, Latorre, Manuela, Scichilone, Nicola, Ricci, Alberto, Cresti, Alberto, Santus, Pierachille, Olivieri, Carmela, Perrella, Antonio, Rogliani, Paola, and Paggiaro, Pierluigi

Published
2019
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74. Age is not the only risk factor in COVID-19: the role of comorbidities and of long staying in residential care homes.

Author

D'Ascanio, Michela, primary, Innammorato, Marta, additional, Pasquariello, Lara, additional, Pizzirusso, Dario, additional, Guerrieri, Giulio, additional, Castelli, Silvia, additional, Pezzuto, Aldo, additional, De Vitis, Claudia, additional, Anibaldi, Paolo, additional, Marcolongo, Adriano, additional, Mancini, Rita, additional, Ricci, Alberto, additional, and Sciacchitano, Salvatore, additional

Published
2020
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76. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis

Author

Lombardi, Mariangela, primary, D'Ascanio, Michela, additional, Scarpino, Stefania, additional, Scozzi, Davide, additional, Giordano, Marco, additional, Costarelli, Leopoldo, additional, Raj, Enrico Rathina, additional, Mancini, Rita, additional, Cardillo, Giuseppe, additional, Cardaci, Vittorio, additional, Innammorato, Marta, additional, Vecchione, Andrea, additional, and Ricci, Alberto, additional

Published
2020
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77. Mepolizumab Effectiveness and Allergic Status in Real Life

Author

Sposato, Bruno, primary, Scalese, Marco, additional, Camiciottoli, Gianna, additional, Carpagnano, Giovanna Elisiana, additional, Pelaia, Corrado, additional, Santus, Pierachille, additional, Maniscalco, Mauro, additional, Corsico, Angelo, additional, Grosso, Amelia, additional, Baglioni, Stefano, additional, Murgia, Nicola, additional, Folletti, Ilenia, additional, Pelaia, Girolamo, additional, Masieri, Simonetta, additional, Cavaliere, Carlo, additional, Musarra, Antonino, additional, Bargagli, Elena, additional, Ricci, Alberto, additional, Latorre, Manuela, additional, Paggiaro, Pierluigi, additional, and Rogliani, Paola, additional

Published
2020
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84. Low FT3 serum values are associated with markers of disease severity, evaluated during the acute phase of COVID-19

Author

Sciacchitano, Salvatore, primary, Giovagnoli, Simonetta, additional, D’Ascanio, Michela, additional, De, Dominicis Chiara, additional, Laghi, Andrea, additional, Anibaldi, Paolo, additional, De, Vitis Claudia, additional, Petrucca, Andrea, additional, Amodeo, Rachele, additional, Simmaco, Maurizio, additional, Napoli, Christian, additional, Mancini, Rita, additional, and Ricci, Alberto, additional

Published
2020
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85. Different recovery from respiratory failure and functional changes after lung cancer surgery depending on the extent of resection, the influence of COPD

Author

Pezzuto, Aldo, primary, Marinucci, Beatrice Trabalza, additional, Pagliuca, Alessandra, additional, Salvucci, Claudia, additional, Guerrieri, Giulio, additional, D’Ascanio, Michela, additional, Ricci, Alberto, additional, Ciccozzi, Massimo, additional, and Rendina, Erino Angelo, additional

Published
2020
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86. Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

Author

Scozzi, Davide, primary, Cano, Marlene, additional, Ma, Lina, additional, Zhou, Dequan, additional, Zhu, Ji Hong, additional, O’Halloran, Jane A, additional, Goss, Charles, additional, Rauseo, Adriana M., additional, Liu, Zhiyi, additional, Peritore, Valentina, additional, Rocco, Monica, additional, Ricci, Alberto, additional, Amodeo, Rachele, additional, Aimati, Laura, additional, Ibrahim, Mohsen, additional, Hachem, Ramsey, additional, Kreisel, Daniel, additional, Mudd, Philip A., additional, Kulkarni, Hrishikesh S., additional, and Gelman, Andrew E., additional

Published
2020
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87. AIDS and COVID-19 are two diseases separated by a common lymphocytopenia

Author

Sciacchitano, Salvatore, primary, Giovagnoli, Simonetta, additional, Amodeo, Rachele, additional, Santino, Iolanda, additional, Simmaco, Maurizio, additional, Anibaldi, Paolo, additional, French, Deborah, additional, Mancini, Rita, additional, Vitis, Claudia De, additional, D'Ascanio, Michela, additional, Ricci, Alberto, additional, Pennica, Alfredo, additional, and Aceti, Antonio, additional

Published
2020
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90. The Exponential Phase of the Covid-19 Pandemic in Central Italy: An Integrated Care Pathway

Author

Capalbo, Carlo, primary, Aceti, Antonio, additional, Simmaco, Maurizio, additional, Bonfini, Rita, additional, Rocco, Monica, additional, Ricci, Alberto, additional, Napoli, Christian, additional, Rocco, Matteo, additional, Alfonsi, Valeria, additional, Teggi, Antonella, additional, Orsi, Giovanni Battista, additional, Borro, Marina, additional, Santino, Iolanda, additional, Preissner, Robert, additional, Marchetti, Paolo, additional, Marcolongo, Adriano, additional, and Anibaldi, Paolo, additional

Published
2020
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94. sj-pdf-1-hsm-10.1177_0951484820962293 - Supplemental material for How to identify the drivers of patient inter-regional mobility in beveridgean systems? Critical review and assessment matrix for policy design & managerial interventions

Author

Ricci, Alberto, Barzan, Elisabetta, and Longo, Francesco

Subjects
111708 Health and Community Services, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-hsm-10.1177_0951484820962293 for How to identify the drivers of patient inter-regional mobility in beveridgean systems? Critical review and assessment matrix for policy design & managerial interventions by Alberto Ricci, Elisabetta Barzan and Francesco Longo in Health Services Management Research

Published
2020
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97. Assessing Static Lung Hyperinflation by Whole-Body Plethysmography, Helium Dilution, and Impulse Oscillometry System (IOS) in Patients with COPD

Author

D'Ascanio,Michela, Viccaro,Fausta, Calabrò,Noemi, Guerrieri,Giulio, Salvucci,Claudia, Pizzirusso,Dario, Mancini,Rita, De Vitis,Claudia, Pezzuto,Aldo, Ricci,Alberto, D'Ascanio,Michela, Viccaro,Fausta, Calabrò,Noemi, Guerrieri,Giulio, Salvucci,Claudia, Pizzirusso,Dario, Mancini,Rita, De Vitis,Claudia, Pezzuto,Aldo, and Ricci,Alberto

Abstract

Michela D’Ascanio,1 Fausta Viccaro,1 Noemi Calabrò,1 Giulio Guerrieri,1 Claudia Salvucci,1 Dario Pizzirusso,1 Rita Mancini,1 Claudia De Vitis,1 Aldo Pezzuto,2 Alberto Ricci1 1Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2Department of Cardiovascular and Respiratory Sciences, Sant’Andrea Hospital, Rome, ItalyCorrespondence: Michela D’Ascanio Via di Grottarossa 1035/1039, Roma 00189, RM, ItalyTel +390633776768Email dascaniomichela87@gmail.comPurpose: Lung hyperinflation is a feature of chronic obstructive pulmonary disease (COPD) and can determine pivotal consequence on symptoms, exercise tolerance and quality of life. Despite the relevance of assessing lung hyperinflation, there is still no single consensus as to what volume should be taken into account. We investigate which spirometric measurement is more reliable in assessing static lung hyperinflation and which is more related with impulse oscillometry system (IOS) measurements in COPD.Patients and Methods: Fifty-five COPD patients were enrolled. TLC, RV and RV:TLC ratio were obtained both with helium and plethysmography techniques. IOS measurements (X5, Fres and R5-R20) were performed. Pearson and Spearman correlation determined the relationships between the functional parameters that evaluate static hyperinflation (RV: TLC, TLC, RV) and IOS measurements.Results: As expected, we reported a statistically significant difference between these two techniques in terms of mean percentage values of TLC (7.57 ± 3.26 L; p= 0.02) and RV (15.24 ± 7.51 L; p=0.04), while RV:TLC measured with the two methods was similar (5.21 ± 4.69%; p=0.27). The correlation analysis showed that IOS parameters, such as difference in resistance between 5 Hz and 20 Hz (R(5– 20)) and resonant frequency (Fres), were positively correlated with RV:TLC ratio, while reactance at 5 Hz (X(5)) wa

Published
2020

99. How to identify the drivers of patient inter-regional mobility in beveridgean systems? Critical review and assessment matrix for policy design & managerial interventions.

Author

Ricci, Alberto, Barzan, Elisabetta, and Longo, Francesco

Subjects
HOSPITAL admission & discharge, POLICY sciences
Abstract

Decentralized, tax-funded health systems like Italian and Spanish ones reveal relevant internal patient flows, raising concerns in terms of equity, budget imbalances, and unexploited economies of scale at the regional and organizational level. However, policymakers lack effective tools to rapidly identify the causes of patient outflows in Beveridgean healthcare systems. We address the gap by conducting a critical review of the drivers of patient mobility. Elaborating on existing knowledge, we propose a concise, versatile assessment matrix to help policymakers in understanding the most relevant causes of mobility. Specifically, we identify three main categories of drivers: insufficient service availability, poor (perceived) quality, and regulatory issues. We include appropriate indicators to identify each driver, or mix of drivers. For each of them, we also propose specific policy and organizational responses. The applicability of the model is proven by an empirical test using the Italian national hospital discharge database for all inter-regional inpatient mobility flows. In addition to adding to previous contributions on mobility drivers by creating a model that informs policymakers' understanding and actions, the paper provides an innovative approach to patient mobility by proposing a model that, for the first time, primarily focuses on the clinical discipline of the flows. [ABSTRACT FROM AUTHOR]

Published
2021
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