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52. Prevalence and long-term prognostic implications of prolonged QRS duration in left ventricular hypertrophy: a population-based observational cohort study

Author

Rankinen, Jani, primary, Haataja, Petri, additional, Lyytikäinen, Leo-Pekka, additional, Huhtala, Heini, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Eskola, Markku, additional, Tuohinen, Suvi, additional, Pérez-Riera, Andrés Ricardo, additional, Jula, Antti, additional, Rissanen, Harri, additional, Nikus, Kjell, additional, and Hernesniemi, Jussi, additional

Published
2022
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54. Prognostic value of P-wave morphology in general population.

Author

Laitinen, Idamaria, Kenttä, Tuomas V, Passi, Jussi, Haukilahti, Mira Anette E, Eranti, Antti, Holkeri, Arttu, Aro, Aapo L, Kerola, Tuomas, Noponen, Kai, Seppänen, Tapio, Rissanen, Harri, Knekt, Paul, Heliövaara, Markku, Ukkola, Olavi H, Junttila, M Juhani, Huikuri, Heikki V, and Perkiömäki, Juha S

Abstract

Aims To evaluate the prognostic significance of novel P-wave morphology descriptors in general population. Methods and results Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from <0.05 to <0.001). After relevant adjustments in the Cox multivariate hazards model, P-wave morphology dispersion (PMD) still tended to predict SCD [hazard ratio (HR): 1.006, 95% confidence interval (CI): 1.000–1.012, P = 0.05) but not NSCD (HR: 0.999, 95% CI: 0.995–1.003, P = 0.68) or NCD (HR: 0.999, 95% CI: 0.997–1.001, P = 0.44). The P-wave maximum amplitude in the lead Z (P-MaxAmp-Z) predicted SCD even after multivariate adjustments (HR: 1.010, 95% CI: 1.005–1.015, P = 0.0002) but also NSCD (HR: 1.005, 95% CI: 1.002–1.009, P = 0.0005) and NCD (HR: 1.002, 95% CI: 1.000–1.005, P = 0.03). Conclusion Abnormalities of P-wave morphology are associated with the risk of all modes of death in general population. After relevant adjustments, PMD was still closely associated with the risk of SCD but not with NSCD or NCD. P-MaxAmp-Z predicted SCD even after adjustments, however, it also retained its association with NSCD and NCD. [ABSTRACT FROM AUTHOR]

Published
2023
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55. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies1-3

Author

Key, Timothy J, Appleby, Paul N, Travis, Ruth C, Albanes, Demetrius, Alberg, Anthony J, Barricarte, Aurelio, Black, Amanda, Boeing, Heiner, Bueno-de-Mesquita, H Bas, Chan, June M, Chen, Chu, Cook, Michael B, Donovan, Jenny L, Galan, Pilar, Gilbert, Rebecca, Giles, Graham G, Giovannucci, Edward, Goodman, Gary E, Goodman, Phyllis J, Gunter, Marc J, Hamdy, Freddie C, Heliövaara, Markku, Helzlsouer, Kathy J, Henderson, Brian E, Hercberg, Serge, Hoffman-Bolton, Judy, Hoover, Robert N, Johansson, Mattias, Khaw, Kay-Tee, King, Irena B, Knekt, Paul, Kolonel, Laurence N, Le Marchand, Loic, Männistö, Satu, Martin, Richard M, Meyer, Haakon E, Mondul, Alison M, Moy, Kristin A, Neal, David E, Neuhouser, Marian L, Palli, Domenico, Platz, Elizabeth A, Pouchieu, Camille, Rissanen, Harri, Schenk, Jeannette M, Severi, Gianluca, Stampfer, Meir J, Tjønneland, Anne, Touvier, Mathilde, Trichopoulou, Antonia, Weinstein, Stephanie J, Ziegler, Regina G, Zhou, Cindy Ke, Allen, Naomi E, and Biomarkers, Nutritional

Published
2015

56. Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

Author

Nettleton, Jennifer A., Follis, Jack L., Ngwa, Julius S., Smith, Caren E., Ahmad, Shafqat, Tanaka, Toshiko, Wojczynski, Mary K., Voortman, Trudy, Lemaitre, Rozenn N., Kristiansson, Kati, Nuotio, Marja-Liisa, Houston, Denise K., Perälä, Mia-Maria, Qi, Qibin, Sonestedt, Emily, Manichaikul, Ani, Kanoni, Stavroula, Ganna, Andrea, Mikkilä, Vera, North, Kari E., Siscovick, David S., Harald, Kennet, Mckeown, Nicola M., Johansson, Ingegerd, Rissanen, Harri, Liu, Yongmei, Lahti, Jari, Hu, Frank B., Bandinelli, Stefania, Rukh, Gull, Rich, Stephen, Booij, Lisanne, Dmitriou, Maria, Ax, Erika, Raitakari, Olli, Mukamal, Kenneth, Männistö, Satu, Hallmans, Göran, Jula, Antti, Ericson, Ulrika, Jacobs, David R., Jr, Van Rooij, Frank J. A., Deloukas, Panos, Sjögren, Per, Kähönen, Mika, Djousse, Luc, Perola, Markus, Barroso, Inês, Hofman, Albert, Stirrups, Kathleen, Viikari, Jorma, Uitterlinden, André G., Kalafati, Ioanna P., Franco, Oscar H., Mozaffarian, Dariush, Salomaa, Veikko, Borecki, Ingrid B., Knekt, Paul, Kritchevsky, Stephen B., Eriksson, Johan G., Dedoussis, George V., Qi, Lu, Ferrucci, Luigi, Orho-Melander, Marju, Zillikens, M. Carola, Ingelsson, Erik, Lehtimäki, Terho, Renström, Frida, Cupples, L. Adrienne, Loos, Ruth J. F., and Franks, Paul W.

Published
2015
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57. Directional dominance on stature and cognition in diverse human populations

Author

Joshi, Peter K., Esko, Tonu, Mattsson, Hannele, Eklund, Niina, Gandin, Ilaria, Nutile, Teresa, Jackson, Anne U., Schurmann, Claudia, Smith, Albert V., Zhang, Weihua, Okada, Yukinori, Stančáková, Alena, Faul, Jessica D., Zhao, Wei, Bartz, Traci M., Concas, Maria Pina, Franceschini, Nora, Enroth, Stefan, Vitart, Veronique, Trompet, Stella, Guo, Xiuqing, Chasman, Daniel I., OʼConnel, Jeffrey R., Corre, Tanguy, Nongmaithem, Suraj S., Chen, Yuning, Mangino, Massimo, Ruggiero, Daniela, Traglia, Michela, Farmaki, Aliki-Eleni, Kacprowski, Tim, Bjonnes, Andrew, van der Spek, Ashley, Wu, Ying, Giri, Anil K., Yanek, Lisa R., Wang, Lihua, Hofer, Edith, Rietveld, Cornelius A., McLeod, Olga, Cornelis, Marilyn C., Pattaro, Cristian, Verweij, Niek, Baumbach, Clemens, Abdellaoui, Abdel, Warren, Helen R., Vuckovic, Dragana, Mei, Hao, Bouchard, Claude, Perry, John R. B., Cappellani, Stefania, Mirza, Saira S., Benton, Miles C., Broeckel, Ulrich, Medland, Sarah E., Lind, Penelope A., Malerba, Giovanni, Drong, Alexander, Yengo, Loic, Bielak, Lawrence F., Zhi, Degui, van der Most, Peter J., Shriner, Daniel, Mägi, Reedik, Hemani, Gibran, Karaderi, Tugce, Wang, Zhaoming, Liu, Tian, Demuth, Ilja, Zhao, Jing Hua, Meng, Weihua, Lataniotis, Lazaros, van der Laan, Sander W., Bradfield, Jonathan P., Wood, Andrew R., Bonnefond, Amelie, Ahluwalia, Tarunveer S., Hall, Leanne M., Salvi, Erika, Yazar, Seyhan, Carstensen, Lisbeth, de Haan, Hugoline G., Abney, Mark, Afzal, Uzma, Allison, Matthew A., Amin, Najaf, Asselbergs, Folkert W., Bakker, Stephan J. L., Barr, Graham R., Baumeister, Sebastian E., Benjamin, Daniel J., Bergmann, Sven, Boerwinkle, Eric, Bottinger, Erwin P., Campbell, Archie, Chakravarti, Aravinda, Chan, Yingleong, Chanock, Stephen J., Chen, Constance, Chen, Ida Y.-D., Collins, Francis S., Connell, John, Correa, Adolfo, Cupples, Adrienne L., Smith, George Davey, Davies, Gail, Dörr, Marcus, Ehret, Georg, Ellis, Stephen B., Feenstra, Bjarke, Feitosa, Mary F., Ford, Ian, Fox, Caroline S., Frayling, Timothy M., Friedrich, Nele, Geller, Frank, Scotland, Generation, Gillham-Nasenya, Irina, Gottesman, Omri, Graff, Misa, Grodstein, Francine, Gu, Charles, Haley, Chris, Hammond, Christopher J., Harris, Sarah E., Harris, Tamara B., Hastie, Nicholas D., Heard-Costa, Nancy L., Heikkilä, Kauko, Hocking, Lynne J., Homuth, Georg, Hottenga, Jouke-Jan, Huang, Jinyan, Huffman, Jennifer E., Hysi, Pirro G., Ikram, Arfan M., Ingelsson, Erik, Joensuu, Anni, Johansson, Åsa, Jousilahti, Pekka, Jukema, Wouter J., Kähönen, Mika, Kamatani, Yoichiro, Kanoni, Stavroula, Kerr, Shona M., Khan, Nazir M., Koellinger, Philipp, Koistinen, Heikki A., Kooner, Manraj K., Kubo, Michiaki, Kuusisto, Johanna, Lahti, Jari, Launer, Lenore J., Lea, Rodney A., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C.M., Lind, Lars, Loh, Marie, Lokki, Marja-Liisa, London, Stephanie J., Loomis, Stephanie J., Loukola, Anu, Lu, Yingchang, Lumley, Thomas, Lundqvist, Annamari, Männistö, Satu, Marques-Vidal, Pedro, Masciullo, Corrado, Matchan, Angela, Mathias, Rasika A., Matsuda, Koichi, Meigs, James B., Meisinger, Christa, Meitinger, Thomas, Menni, Cristina, Mentch, Frank D., Mihailov, Evelin, Milani, Lili, Montasser, May E., Montgomery, Grant W., Morrison, Alanna, Myers, Richard H., Nadukuru, Rajiv, Navarro, Pau, Nelis, Mari, Nieminen, Markku S., Nolte, Ilja M., OʼConnor, George T., Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmas, Walter R., Pankow, James S., Patarcic, Inga, Pavani, Francesca, Peyser, Patricia A., Pietilainen, Kirsi, Poulter, Neil, Prokopenko, Inga, Ralhan, Sarju, Redmond, Paul, Rich, Stephen S., Rissanen, Harri, Robino, Antonietta, Rose, Lynda M., Rose, Richard, Sala, Cinzia, Salako, Babatunde, Salomaa, Veikko, Sarin, Antti-Pekka, Saxena, Richa, Schmidt, Helena, Scott, Laura J., Scott, William R., Sennblad, Bengt, Seshadri, Sudha, Sever, Peter, Shrestha, Smeeta, Smith, Blair H., Smith, Jennifer A., Soranzo, Nicole, Sotoodehnia, Nona, Southam, Lorraine, Stanton, Alice V., Stathopoulou, Maria G., Strauch, Konstantin, Strawbridge, Rona J., Suderman, Matthew J., Tandon, Nikhil, Tang, Sian-Tsun, Taylor, Kent D., Tayo, Bamidele O., Töglhofer, Anna Maria, Tomaszewski, Maciej, Tšernikova, Natalia, Tuomilehto, Jaakko, Uitterlinden, Andre G., Vaidya, Dhananjay, van Hylckama Vlieg, Astrid, van Setten, Jessica, Vasankari, Tuula, Vedantam, Sailaja, Vlachopoulou, Efthymia, Vozzi, Diego, Vuoksimaa, Eero, Waldenberger, Melanie, Ware, Erin B., Wentworth-Shields, William, Whitfield, John B., Wild, Sarah, Willemsen, Gonneke, Yajnik, Chittaranjan S., Yao, Jie, Zaza, Gianluigi, Zhu, Xiaofeng, Salem, Rany M., Melbye, Mads, Bisgaard, Hans, Samani, Nilesh J., Cusi, Daniele, Mackey, David A., Cooper, Richard S., Froguel, Philippe, Pasterkamp, Gerard, Grant, Struan F.A., Hakonarson, Hakon, Ferrucci, Luigi, Scott, Robert A., Morris, Andrew D., Palmer, Colin N. A., Dedoussis, George, Deloukas, Panos, Bertram, Lars, Lindenberger, Ulman, Berndt, Sonja I., Lindgren, Cecilia M., Timpson, Nicholas J., Tönjes, Anke, Munroe, Patricia B., Sørensen, Thorkild I. A., Rotimi, Charles N., Arnett, Donna K., Oldehinkel, Albertine J., Kardia, Sharon L. R., Balkau, Beverley, Gambaro, Giovanni, Morris, Andrew P., Eriksson, Johan G., Wright, Margie J., Martin, Nicholas G., Hunt, Steven C., Starr, John M., Deary, Ian J., Griffiths, Lyn R., Tiemeier, Henning, Pirastu, Nicola, Kaprio, Jaakko, Wareham, Nicholas J., Pérusse, Louis, Wilson, James G., Girotto, Giorgia, Caulfield, Mark J., Raitakari, Olli, Boomsma, Dorret I., Gieger, Christian, van der Harst, Pim, Hicks, Andrew A., Kraft, Peter, Sinisalo, Juha, Knekt, Paul, Johannesson, Magnus, Magnusson, Patrik K. E., Hamsten, Anders, Schmidt, Reinhold, Borecki, Ingrid B., Vartiainen, Erkki, Becker, Diane M., Bharadwaj, Dwaipayan, Mohlke, Karen L., Boehnke, Michael, van Duijn, Cornelia M., Sanghera, Dharambir K., Teumer, Alexander, Zeggini, Eleftheria, Metspalu, Andres, Gasparini, Paolo, Ulivi, Sheila, Ober, Carole, Toniolo, Daniela, Rudan, Igor, Porteous, David J., Ciullo, Marina, Spector, Tim D., Hayward, Caroline, Dupuis, Josée, Loos, Ruth J. F., Wright, Alan F., Chandak, Giriraj R., Vollenweider, Peter, Shuldiner, Alan R., Ridker, Paul M., Rotter, Jerome I., Sattar, Naveed, Gyllensten, Ulf, North, Kari E., Pirastu, Mario, Psaty, Bruce M., Weir, David R., Laakso, Markku, Gudnason, Vilmundur, Takahashi, Atsushi, Chambers, John C., Kooner, Jaspal S., Strachan, David P., Campbell, Harry, Hirschhorn, Joel N., Perola, Markus, Polašek, Ozren, and Wilson, James F.

Published
2015
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58. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Author

Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., and Qi, Lu

Published
2014
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65. Electrocardiographic Risk Markers of Cardiac Death: Gender Differences in the General Population

Author

Haukilahti, Mira Anette E., primary, Kenttä, Tuomas V., additional, Tikkanen, Jani T., additional, Anttonen, Olli, additional, Aro, Aapo L., additional, Kerola, Tuomas, additional, Eranti, Antti, additional, Holkeri, Arttu, additional, Rissanen, Harri, additional, Heliövaara, Markku, additional, Knekt, Paul, additional, Junttila, M. Juhani, additional, and Huikuri, Heikki V., additional

Published
2021
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66. Pooling of Finnish population-based health studies: lifestyle risk factors of colorectal and lung cancer

Author

Pitkäniemi, Janne, Heikkinen, Sanna, Seppä, Karri, Ryynänen, Heidi, Ylöstalo, Tiina, Eriksson, Johan G., Härkänen, Tommi, Jousilahti, Pekka, Knekt, Paul, Koskinen, Seppo, Männistö, Satu, Albanes, Demetrius, Rissanen, Harri, Malila, Nea, and Laaksonen, Maarit A.

Subjects
respiratory system
Abstract

Pooling of Finnish population-based health studies: lifestyle risk factors of colorectal and lung cancer

Published
2020
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69. Improving health‐related quality of life in glaucoma during 11 years and its association with vision loss and treatment of the disease.

Author

Purola, Petri K.M., Nättinen, Janika E., Parkkari, Minna M., Ojamo, Matti U.I., Koskinen, Seppo V.P., Rissanen, Harri A., Sainio, Päivi R.J., and Uusitalo, Hannu M.T.

Subjects
VISION disorders, QUALITY of life, THERAPEUTICS, EYE diseases, GLAUCOMA, LOGISTIC regression analysis
Abstract

Purpose: To evaluate the impact of glaucoma on health‐related quality of life (HRQoL) and mental health in the ageing population of Finland. Methods: Altogether 7380 and 5774 Finnish individuals aged 30 years and older with known eye disease status were studied in 2000 and 2011, respectively, in two population‐based surveys, including an 11‐year follow‐up of 4683 participants. Data on HRQoL (EQ‐5D‐3L, 15D), depression (BDI), psychological distress (GHQ‐12) and eye disease diagnoses were obtained from self‐reported assessments. Information on glaucoma was complemented with the medication, diagnosis and eye surgery data obtained from the Finnish Health Registries. Distance visual acuity was assessed using the Snellen eye chart test. In logistic regression analyses, data were corrected for age, gender and the most common comorbidities. Results: Glaucoma patients with verified diagnosis (n = 192 in 2000, n = 202 in 2011) and individuals with self‐suspected glaucoma (n = 100 in 2000, n = 41 in 2011) showed a significant decrease in their HRQoL. Glaucoma was also associated with worsened overall mental health based on BDI and GHQ‐12 results. Visual impairment associated with glaucoma is the major determinant of the reduced HRQoL and mental health. Neither glaucoma medication nor glaucoma surgery affected these parameters. The impact of glaucoma on HRQoL and mental health diminished between 2000 and 2011 in a cross‐sectional setting. The newly diagnosed glaucoma during the 11‐year follow‐up had a minimal effect on them. Conclusion: Glaucoma patients show reduced HRQoL and mental health, which is associated with vision loss regardless of the awareness or treatment of the disease. However, this effect seems to be diminishing over time, and the newly diagnosed glaucoma did not show a significant effect on either HRQoL or mental health. [ABSTRACT FROM AUTHOR]

Published
2022
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72. The prognostic significance of T‐wave inversion according to ECG lead group during long‐term follow‐up in the general population

Author

Istolahti, Tiia, primary, Lyytikäinen, Leo‐Pekka, additional, Huhtala, Heini, additional, Nieminen, Tuomo, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Eskola, Markku, additional, Anttila, Ismo, additional, Jula, Antti, additional, Rissanen, Harri, additional, Nikus, Kjell, additional, and Hernesniemi, Jussi, additional

Published
2020
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73. Long‐term outcome of intraventricular conduction delays in the general population

Author

Rankinen, Jani, primary, Haataja, Petri, additional, Lyytikäinen, Leo‐Pekka, additional, Huhtala, Heini, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Eskola, Markku, additional, Pérez‐Riera, Andrés Ricardo, additional, Jula, Antti, additional, Rissanen, Harri, additional, Nikus, Kjell, additional, and Hernesniemi, Jussi, additional

Published
2020
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74. Gender differences in prevalence and prognostic value of fragmented QRS complex

Author

Haukilahti, M. Anette E., primary, Holmström, Lauri, additional, Vähätalo, Juha, additional, Tikkanen, Jani T., additional, Terho, Henri K., additional, Kiviniemi, Antti M., additional, Lepojärvi, E. Samuli, additional, Tulppo, Mikko, additional, Perkiömäki, Juha S., additional, Ukkola, Olavi H., additional, Anttonen, Olli, additional, Aro, Aapo L., additional, Kerola, Tuomas, additional, Rissanen, Harri, additional, Knekt, Paul, additional, Junttila, M. Juhani, additional, Huikuri, Heikki V., additional, and Kenttä, Tuomas V., additional

Published
2020
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75. Orthogonal P-wave morphology, conventional P-wave indices, and the risk of atrial fibrillation in the general population using data from the Finnish Hospital Discharge Register

Author

Eranti, Antti, primary, Carlson, Jonas, additional, Kenttä, Tuomas, additional, Holmqvist, Fredrik, additional, Holkeri, Arttu, additional, Haukilahti, M Anette, additional, Kerola, Tuomas, additional, Aro, Aapo L, additional, Rissanen, Harri, additional, Noponen, Kai, additional, Seppänen, Tapio, additional, Knekt, Paul, additional, Heliövaara, Markku, additional, Huikuri, Heikki V, additional, Junttila, M Juhani, additional, and Platonov, Pyotr G, additional

Published
2020
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76. Long-term prognostic significance of the ST level and ST slope in the 12‑lead ECG in the general population

Author

Istolahti, Tiia, primary, Nieminen, Tuomo, additional, Huhtala, Heini, additional, Lyytikäinen, Leo-Pekka, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Eskola, Markku, additional, Anttila, Ismo, additional, Jula, Antti, additional, Rissanen, Harri, additional, Nikus, Kjell, additional, and Hernesniemi, Jussi, additional

Published
2020
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79. Predicting sudden cardiac death in a general population using an electrocardiographic risk score

Author

Holkeri, Arttu, primary, Eranti, Antti, additional, Haukilahti, M Anette E, additional, Kerola, Tuomas, additional, Kenttä, Tuomas V, additional, Tikkanen, Jani T, additional, Anttonen, Olli, additional, Noponen, Kai, additional, Seppänen, Tapio, additional, Rissanen, Harri, additional, Heliövaara, Markku, additional, Knekt, Paul, additional, Junttila, M Juhani, additional, Huikuri, Heikki V, additional, and Aro, Aapo L, additional

Published
2019
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82. Incidence trends and risk factors of lung cancer in never smokers: Pooled analyses of seven cohorts.

Author

Rissanen, Emilia, Heikkinen, Sanna, Seppä, Karri, Ryynänen, Heidi, Eriksson, Johan G., Härkänen, Tommi, Jousilahti, Pekka, Knekt, Paul, Koskinen, Seppo, Männistö, Satu, Rahkonen, Ossi, Rissanen, Harri, Malila, Nea, Laaksonen, Maarit A, and Pitkäniemi, Janne

Subjects
LUNG cancer, PASSIVE smoking, DISEASE risk factors, BODY mass index, POISSON regression
Abstract

The trends in incidence of lung cancer in never smokers are unclear as well as the significance of risk factors. We studied time trends in the incidence and risk factors of lung cancer in never smokers in Finland in a large, pooled cohort. We pooled data from seven Finnish health cohorts from the period between 1972 and 2015 with 106 193 never smokers. The harmonised risk factors included education, alcohol consumption, physical activity, height and BMI. We retrieved incident lung cancers from the nation‐wide Finnish Cancer Registry. We estimated average annual percent change (AAPC) and the effects of risk factors on cause‐specific hazard ratios (HRs) of lung cancer using Poisson regression. We detected 47 lung cancers in never smoking men (n = 31 859) and 155 in never smoking women (n = 74 334). The AAPC of lung cancer incidence was −3.30% (95% confidence interval [CI]: −5.68% to −0.88%, P =.009) in never smoking men and 0.00% (95% CI: −1.57% to 1.60%, P =.996) in never smoking women. Of the five studied risk factors only greater height in women had a statistically significant increased risk of lung cancer (multivariate HR = 1.84, 95%CI: 1.08 to 3.12). It is plausible that tobacco control measures focused on working places have reduced passive smoking among men more than among women, which could explain the declining trend in lung cancer incidence in never smoker men but not in never smoker women. As tobacco control measures have not been targeted to domestic environments, it is likely that women's exposure to passive smoking has continued longer. What's New The incidence trends and risk factors of lung cancer in never smokers remain unclear. In a harmonised population‐based cohort of 106,193 never smokers, here the authors found a decreasing trend of lung cancer incidence in men and no trend in women. Among several possible risk factors including education, alcohol consumption, physical activity, height, and body mass index, the results confirmed the association between greater height and lung cancer risk in women. As tobacco control measures have only targeted working and not domestic environments, it is plausible that women's exposure to passive smoking has continued for a longer time than men's exposure. [ABSTRACT FROM AUTHOR]

Published
2021
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84. Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Author

PRACTICAL Consortium, Law, Philip J., Timofeeva, Maria, Fernandez-Rozadilla, Ceres, Palin, Kimmo, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Jousilahti, Pekka, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Aaltonen, Lauri A., Rissanen, Harri, Salomaa, Veikko, Böhm, Jan, Mecklin, Jukka-Pekka, Pukkala, Eero, Lauri Antti Aaltonen / Principal Investigator, Genome-Scale Biology (GSB) Research Program, Research Programs Unit, Department of Medical and Clinical Genetics, Medicum, University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Doctoral Programme in Biomedicine, Institute for Molecular Medicine Finland, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Clinicum, Centre of Excellence in Complex Disease Genetics, Department of Public Health, Samuli Olli Ripatti / Principal Investigator, Biostatistics Helsinki, Aarno Palotie / Principal Investigator, Department of Surgery, II kirurgian klinikka, HUS Abdominal Center, Complex Disease Genetics, and Genomics of Neurological and Neuropsychiatric Disorders

Subjects
CHROMATIN, IDENTIFICATION, HERITABILITY, COHORT PROFILE, IMPUTATION, 1184 Genetics, developmental biology, physiology, TRANSCRIPTION FACTOR-BINDING, GWAS, 3111 Biomedicine, GENOME-WIDE ASSOCIATION, neoplasms, digestive system diseases, METAANALYSIS
Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.

Published
2019

89. A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk

Author

Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, MS MDL 1, Travis, Ruth C, Perez-Cornago, Aurora, Appleby, Paul N, Albanes, Demetrius, Joshu, Corinne E, Lutsey, Pamela L, Mondul, Alison M, Platz, Elizabeth A, Weinstein, Stephanie J, Layne, Tracy M, Helzlsouer, Kathy J, Visvanathan, Kala, Palli, Domenico, Peeters, Petra H, Bueno-de-Mesquita, Bas, Trichopoulou, Antonia, Gunter, Marc J, Tsilidis, Konstantinos K, Sánchez, Maria-Jose, Olsen, Anja, Brenner, Hermann, Schöttker, Ben, Perna, Laura, Holleczek, Bernd, Knekt, Paul, Rissanen, Harri, Yeap, Bu B, Flicker, Leon, Almeida, Osvaldo P, Wong, Yuen Yee Elizabeth, Chan, June M, Giovannucci, Edward L, Stampfer, Meir J, Ursin, Giske, Gislefoss, Randi E, Bjørge, Tone, Meyer, Haakon E, Blomhoff, Rune, Tsugane, Shoichiro, Sawada, Norie, English, Dallas R, Eyles, Darryl W, Heath, Alicia K, Williamson, Elizabeth J, Manjer, Jonas, Malm, Johan, Almquist, Martin, Marchand, Loic Le, Haiman, Christopher A, Wilkens, Lynne R, Schenk, Jeannette M, Tangen, Cathy M, Black, Amanda, Cook, Michael B, Huang, Wen-Yi, Ziegler, Regina G, Martin, Richard M, Hamdy, Freddie C, Donovan, Jenny L, Neal, David E, Touvier, Mathilde, Hercberg, Serge, Galan, Pilar, Deschasaux, Mélanie, Key, Timothy J, Allen, Naomi E, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, MS MDL 1, Travis, Ruth C, Perez-Cornago, Aurora, Appleby, Paul N, Albanes, Demetrius, Joshu, Corinne E, Lutsey, Pamela L, Mondul, Alison M, Platz, Elizabeth A, Weinstein, Stephanie J, Layne, Tracy M, Helzlsouer, Kathy J, Visvanathan, Kala, Palli, Domenico, Peeters, Petra H, Bueno-de-Mesquita, Bas, Trichopoulou, Antonia, Gunter, Marc J, Tsilidis, Konstantinos K, Sánchez, Maria-Jose, Olsen, Anja, Brenner, Hermann, Schöttker, Ben, Perna, Laura, Holleczek, Bernd, Knekt, Paul, Rissanen, Harri, Yeap, Bu B, Flicker, Leon, Almeida, Osvaldo P, Wong, Yuen Yee Elizabeth, Chan, June M, Giovannucci, Edward L, Stampfer, Meir J, Ursin, Giske, Gislefoss, Randi E, Bjørge, Tone, Meyer, Haakon E, Blomhoff, Rune, Tsugane, Shoichiro, Sawada, Norie, English, Dallas R, Eyles, Darryl W, Heath, Alicia K, Williamson, Elizabeth J, Manjer, Jonas, Malm, Johan, Almquist, Martin, Marchand, Loic Le, Haiman, Christopher A, Wilkens, Lynne R, Schenk, Jeannette M, Tangen, Cathy M, Black, Amanda, Cook, Michael B, Huang, Wen-Yi, Ziegler, Regina G, Martin, Richard M, Hamdy, Freddie C, Donovan, Jenny L, Neal, David E, Touvier, Mathilde, Hercberg, Serge, Galan, Pilar, Deschasaux, Mélanie, Key, Timothy J, and Allen, Naomi E

Published
2019

92. Flavonoid intake and risk of chronic diseases

Author

Knekt, Paul, Kumpulainen, Jorma, Jarvinen, Ritva, Rissanen, Harri, Heliovaara, Markku, Reunanen, Antti, Hakulinen, Timo, and Aromaa, Arpo

Subjects
Chronic diseases -- Risk factors, Diet -- Health aspects, Flavonoids -- Health aspects, Flavones -- Health aspects, Food/cooking/nutrition, Health
Abstract

Background: Flavonoids are effective antioxidants and may protect against several chronic diseases. Objective: The association between flavonoid intake and risk of several chronic diseases was studied. Design: The total dietary intakes of 10 054 men and women during the year preceding the baseline examination were determined with a dietary history method. Flavonoid intakes were estimated, mainly on the basis of the flavonoid concentrations in Finnish foods. The incident cases of the diseases considered were identified from different national public health registers. Results: Persons with higher quercetin intakes had lower mortality from ischemic heart disease. The relative risk (RR) between the highest and lowest quartiles was 0.79 (95% CI: 0.63, 0.99: P for trend = 0.02). The incidence of cerebrovascular disease was lower at higher kaempferol (0.70; 0.56, 0.86; P = 0.003), naringenin (0.79; 0.64, 0.98; P = 0.06), and hesperetin (0.80; 0.64, 0.99; P = 0.008) intakes. Men with higher quercetin intakes had a lower lung cancer incidence (0.42; 0.25, 0.72; P = 0.001), and men with higher myricetin intakes had a lower prostate cancer risk (0.43; 0.22, 0.86; P = 0.002). Asthma incidence was lower at higher quercetin (0.76; 0.56, 1.01; P = 0.005), naringenin (0.69; 0.50, 0.94; P = 0.06), and hesperetin (0.64; 0.46, 0.88; P = 0.03) intakes. A trend toward a reduction in risk of type 2 diabetes was associated with higher quercetin (0.81; 0.64, 1.02; P = 0.07) and myricetin (0.79; 0.62, 1.00; P = 0.07) intakes. Conclusion: The risk of some chronic diseases may be lower at higher dietary flavonoid intakes. KEY WORDS Chronic disease, diet, flavonoids, flavonols, flavanones, flavones, prospective study, free radicals

Published
2002

94. Low Free Testosterone and Prostate Cancer Risk : A Collaborative Analysis of 20 Prospective Studies

Author

Watts, Eleanor L., Appleby, Paul N., Perez-Cornago, Aurora, Bueno-de-Mesquita, H. Bas, Chan, June M., Chen, Chu, Cohn, Barbara A., Cook, Michael B., Flicker, Leon, Freedman, Neal D., Giles, Graham G., Giovannucci, Edward, Gislefoss, Randi E., Hankey, Graeme J., Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N., Kubo, Tatsuhiko, Le Marchand, Loic, Luben, Robert N., Luostarinen, Tapio, Mannisto, Satu, Metter, E. Jeffrey, Mikami, Kazuya, Milne, Roger L., Ozasa, Kotaro, Platz, Elizabeth A., Quiros, J. Ramon, Rissanen, Harri, Sawada, Norie, Stampfer, Meir, Stanczyk, Frank Z., Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M., Thompson, Ian M., Tsilidis, Konstantinos K., Tsugane, Shoichiro, Ursin, Giske, Vatten, Lars, Weiss, Noel S., Yeap, Bu B., Allen, Naomi E., Key, Timothy J., and Travis, Ruth C.

Subjects
Adult, Male, Urologic Diseases, Aging, Time Factors, Epidemiology, Clinical Sciences, FLOATING ABSOLUTE RISK, Down-Regulation, Risk Assessment, Pooled analysis, SEX STEROID ASSAYS, Risk Factors, Clinical Research, Urologi och njurmedicin, Humans, 2.1 Biological and endogenous factors, Urology and Nephrology, Sex hormones, Testosterone, Prospective Studies, Aetiology, Aged, Cancer, PREVENTION TRIAL, Science & Technology, Prostate cancer, Prevention, ANDROGEN RECEPTOR, Prostatic Neoplasms, MEN, 1103 Clinical Sciences, MASS-SPECTROMETRY, Androgens Pooled analysis, Middle Aged, Protective Factors, Urology & Nephrology, SERUM TESTOSTERONE, Case-Control Studies, Androgens, FINASTERIDE, CLINICAL-IMPLICATIONS, HORMONES, Neoplasm Grading, Life Sciences & Biomedicine, Prospective studies, Biomarkers
Abstract

Background Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. Objective To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Design, setting, and participants Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Outcome measurements and statistical analysis Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Results and limitations Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR = 0.77, 95% confidence interval [CI] 0.69–0.86; p < 0.001) compared with men with higher concentrations (2nd–10th tenths of the distribution). Heterogeneity was present by tumour grade (phet = 0.01), with a lower risk of low-grade disease (OR = 0.76, 95% CI 0.67–0.88) and a nonsignificantly higher risk of high-grade disease (OR = 1.56, 95% CI 0.95–2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Conclusions Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. Patient summary In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer. © 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Published
2018

95. Risk Factors Associated With Atrioventricular Block

Author

Kerola, Tuomas, primary, Eranti, Antti, additional, Aro, Aapo L., additional, Haukilahti, M. Anette, additional, Holkeri, Arttu, additional, Junttila, M. Juhani, additional, Kenttä, Tuomas V., additional, Rissanen, Harri, additional, Vittinghoff, Eric, additional, Knekt, Paul, additional, Heliövaara, Markku, additional, Huikuri, Heikki V., additional, and Marcus, Gregory M., additional

Published
2019
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98. Long-term prognostic impact of hyperuricemia in community

Author

Kerola, Tuomas, primary, Kauppi, Jenni, additional, Sares-Jäske, Laura, additional, Anttonen, Olli, additional, Junttila, M Juhani, additional, Huikuri, Heikki V, additional, Nieminen, Tuomo, additional, Rissanen, Harri, additional, Heliövaara, Markku, additional, Kauppi, Markku J, additional, Knekt, Paul, additional, and Eranti, Antti, additional

Published
2019
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99. Associations of Metabolic Syndrome and Its Components with the Risk of Incident Knee Osteoarthritis Leading to Hospitalization: A 32-Year Follow-up Study

Author

Konstari, Sanna, Sääksjärvi, Katri, Heliövaara, Markku, Rissanen, Harri, Knekt, Paul, Arokoski, Jari P. A., and Karppinen, Jaro

Abstract

Objectives To examine whether metabolic syndrome or its individual components predict the risk of incident knee osteoarthritis (OA) in a prospective cohort study during a 32-year follow-up period.Design The cohort consisted of 6274 participants of the Mini-Finland Health Survey, who were free from knee OA and insulin-treated diabetes at baseline. Information on the baseline characteristics, including metabolic syndrome components, hypertension, elevated fasting glucose, elevated triglycerides, reduced high-density lipoprotein, and central obesity were collected during a health examination. We drew information on the incidence of clinical knee OA from the national Care Register for Health Care. Of the participants, 459 developed incident knee OA. In our full model, age, gender, body mass index, history of physical workload, smoking history, knee complaint, and previous injury of the knee were entered as potential confounding factors.Results Having metabolic syndrome at baseline was not associated with an increased risk of incident knee OA. In the full model, the hazard ratio for incident knee OA for those with metabolic syndrome was 0.76 (95% confidence interval [0.56, 1.01]). The number of metabolic syndrome components or any individual component did not predict an increased risk of knee OA. Of the components, elevated plasma fasting glucose was associated with a reduced risk of incident knee OA (hazard ratio 0.71, 95% confidence interval [0.55, 0.91]).Conclusions Our findings do not support the hypothesis that metabolic syndrome or its components increase the risk of incident knee OA. In fact, elevated fasting glucose levels seemed to predict a reduced risk.

Published
2021
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100. Fat free mass and obesity in relation to educational level

Author

Rissanen Harri, Knekt Paul, Männistö Satu, Lahti-Koski Marjaana, Seppänen-Nuijten Elina, Aromaa Arpo, and Heliövaara Markku

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background The aim of the study was to describe the body composition of Finnish adults, especially by education, and to investigate whether fat-free mass (FFM) can explain educational gradients relating to body mass index (BMI) and waist-to-hip ratio (WHR). Methods Data for this cross-sectional study were based on data collected in 2000-2001 for the Health 2000 Survey. Of the nationally representative sample of 8,028 Finnish men and women aged 30 years and older, 6,300 (78.5%) were included in the study. Body composition measurements were carried out in the health examination, where FFM was assessed with eight-polar bioelectrical impedance analysis. Questions on education were included in the health interview. Results The mean FFM varied by education in older (≥ 65 y.) men only. In the middle-aged group (30-64 y.), highly educated men were less likely to belong to the lowest quintile of FFM (OR 0.67, 95%CI 0.48-0.93) compared with the least educated subjects. The level of education was inversely associated with the prevalence of high BMI and WHR in middle-aged men. In women, the respective associations were found both in middle-aged women and their older counterparts. Adjustment for FFM slightly strengthened the associations of education with BMI and WHR. Conclusions The association between education and FFM is weak. Educational gradients of high BMI and high WHR cannot be explained by FFM.

Published
2009
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