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Organized by the Belgian Society of Intensive Care and Emergency Medicine, info:eu-repo/semantics/nonPublished

info:eu-repo/semantics/nonPublished

We recently observed a 45-year-old patient with a history of psychiatric illness who presented with severe hyperthermia (rectal temperature above 41°C) with intense rhabdomyolysis and liver cytolysis during tetrabenazine therapy for neuroleptic tardive dyskinesia. In addition to tetrabenazine, this patient took lorazepam and two antidepressant drugs: clomipramine, a potent serotonin-reuptake inhibitor, and mianserin. Hyperthermia responded to parenteral sodium dantrolene and oral bromocriptine administration. The significant role of tetrabenazine (a central nervous system dopamine-depleting drug) and the contribution of antidepressants to the mechanism of this neuroleptic malignant syndrome-like hyperthermia are discussed., SCOPUS: ar.j, info:eu-repo/semantics/published

info:eu-repo/semantics/published

Organized by the Belgian Society of Intensive Care and Emergency Medicine, info:eu-repo/semantics/nonPublished

info:eu-repo/semantics/published

SCOPUS: ar.j, info:eu-repo/semantics/published

We explored the effects of balloon filling into the inferior vena cava as a relatively simple and atraumatic method to study the relationship between oxygen uptake (V̇O2) and oxygen supply (DO2) during an acute reduction in blood flow. Via a femoral vein, a Foley catheter was inserted with its balloon placed above the renal veins and filled with fluid for 40 minutes. A fluid challenge with saline was performed before and during the balloon filling. In nine control dogs, the critical DO2 (DO(2crit)) below which V̇O2 started to decline was found at 18.5 mL/kg/min. In nine dogs receiving endotoxin as a bolus of 0.5 mg/kg followed by an infusion of 0.02 mg/kg/min, the DO(2crit) was found at 18.4 mL/kg/min. In seven dogs, increasing doses of endotoxin did not influence DO(2crit). In two dogs, prolonged balloon filling demonstrated the stability and also the reversibility of the model. As the DO(2crit) is much higher on this model than in other studies using acute hemorrhage, six dogs were submitted first to balloon filling and second to hemorrhage. The DO(2crit) was 14.6 mL/kg/min during balloon filling but only 9.0 mL/kg/min during hemorrhage (P < .01). These differences in extraction capabilities are probably due to blood flow redistribution in the present model. Thus, balloon filling in the inferior vena cava represents a relatively atraumatic and reversible model to study the effects of an acute reduction in blood flow on the V̇O2/DO2 relationship. However, the DO(2crit) is significantly higher in this balloon-filling model than in hemorrhagic models. In the present study, effects of endotoxin on the tissues' extraction capabilities could not be demonstrated. In view of the probable effects of balloon filling on the distribution of blood flow, this model might not be suitable to study global changes in V̇O2/DO2 relationships., SCOPUS: ar.j, info:eu-repo/semantics/published

SCOPUS: ar.j, info:eu-repo/semantics/published

SCOPUS: ar.j, info:eu-repo/semantics/published

Out of a total of 31 patients (26 females and five males) there were 24 complete and nine impending pathological fractures. These, treated from October 1985 to September 1987 at the Bordet Institute, were evaluated. Breast cancer was the most frequent underlying disease (66%) followed by lung cancer (12%). Eighteen lesions were treated by endoprosthetic replacement and 15 by an intramedullary fixation device. Bone cement was added to either of these. Satisfactory pain relief was obtained in 82% of the treated areas and restoration of function in 76%. Complications were rare but included one easily resolved superficial wound infection, four deep venous thromboses, movement limited to 21% (seven joints), and the changing of two fixation or reconstruction devices. Median survival time was 6 months; 35% of the patients were still alive after 12 months and 10% after 24 months., Journal Article, SCOPUS: ar.j, info:eu-repo/semantics/published

Calbindin-27 kDa immunocytochemical localization was studied concurrently in the pineal organ and retina from human as well as representatives of all vertebrate classes. Calbindin immunoreactivity was demonstrated in retinal cones (but not in rods) and in pineal transducers (cone-like and modified photoreceptor cells, pinealocytes) of a majority of amniotes. In contrast, no labelling was observed in anamniotes, except in retinal cones of the toad. Labelling was distributed through all cellular compartments (outer and inner segments, perikarya, pedicles or processes) of pineal transducers and retinal cones. Intra- and interspecific variations of calbindin contents are discussed., Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Calbindin 28K and calretinin are very similar calcium binding proteins which are both present in the central nervous system (CNS). They respectively bind 4 and 5 Ca++ ions. We have compared by immunohistochemistry and in situ hybridization their localisation in the brain and the retina. The two proteins are generally expressed in different neurons with a few neurons containing both calcium binding proteins. Calbindin 28K is also present in the endocrine system. We have examined the cellular distribution of calbindin in the pancreatic endocrine cells of chick, rat and human and found variable distribution among the different endocrine cell types. We also describe the presence of calbindin in RINm5F cells, an insulin-producing tumor cell line derived from a radiation-induced rat insulinoma., Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

SCOPUS: re.j, info:eu-repo/semantics/published