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59. OC-07A machine learning approach for the classification of NASH vs NAFL in diabetic and non-diabetic subjects reveals a strong association between liver inflammation and adipose tissue dysfunction

Author

Sabatini, S., primary, Gaggini, M., additional, Allison, M., additional, Younes, R., additional, Rosso, C., additional, Schattenberg, J.M., additional, Ratziu, V., additional, Bugianesi, E., additional, Anstee, Q.M., additional, and Gastaldelli, A., additional

Published
2021
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60. Progress in the integrated simulation of thermal-hydraulic operation of the ITER magnet system

Author

Bagnasco, M., Bessette, D., Bottura, L., Marinucci, C., and Rosso, C.

Subjects
Superconducting magnets -- Thermal properties, Superconducting magnets -- Design and construction, Technical institutes -- Management, Company business management, Business, Electronics, Electronics and electrical industries, International Thermonuclear Experimental Reactor -- Management
Published
2010

61. RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author

Brady, MC, Ali, M, VandenBerg, K, Williams, LJ, Williams, LR, Abo, M, Becker, F, Bowen, A, Brandenburg, C, Breitenstein, C, Bruehl, S, Copland, DA, Cranfill, TB, Pietro-Bachmann, MD, Enderby, P, Fillingham, J, Galli, FL, Gandolfi, M, Glize, B, Godecke, E, Hawkins, N, Hilari, K, Hinckley, J, Horton, S, Howard, D, Jaecks, P, Jefferies, E, Jesus, LMT, Kambanaros, M, Kang, EK, Khedr, EM, Kong, APH, Kukkonen, T, Laganaro, M, Ralph, MAL, Laska, AC, Leemann, B, Leff, AP, Lima, RR, Lorenz, A, MacWhinney, B, Marshall, RS, Mattioli, F, Maviş, İ, Meinzer, M, Nilipour, R, Noé, E, Paik, NJ, Palmer, R, Papathanasiou, I, Patricio, BF, Martins, IP, Price, C, Jakovac, TP, Rochon, E, Rose, ML, Rosso, C, Rubi-Fessen, I, Ruiter, MB, Snell, C, Stahl, B, Szaflarski, JP, Thomas, SA, Van De Sandt-Koenderman, M, Van Der Meulen, I, Visch-Brink, E, Worrall, L, Wright, HH, Brady, MC [0000-0002-4589-7021], Ali, M [0000-0001-5899-2485], VandenBerg, K [0000-0001-5035-9650], Williams, LJ [0000-0002-6317-1718], Williams, LR [0000-0003-2430-1142], Abo, M [0000-0001-6701-4974], Becker, F [0000-0002-0857-0628], Bowen, A [0000-0003-4075-1215], Brandenburg, C [0000-0002-6992-7790], Breitenstein, C [0000-0002-6408-873X], Bruehl, S [0000-0003-4826-1990], Copland, DA [0000-0002-2257-4270], Cranfill, TB [0000-0001-7608-6443], Pietro-Bachmann, MD [0000-0001-8027-2337], Enderby, P [0000-0002-4371-9053], Fillingham, J [0000-0002-0363-8021], Galli, FL [0000-0001-9244-9179], Gandolfi, M [0000-0002-0877-4807], Glize, B [0000-0001-9618-2088], Hawkins, N [0000-0002-7210-1295], Hilari, K [0000-0003-2091-4849], Hinckley, J [0000-0002-4052-1420], Horton, S [0000-0002-2133-1410], Howard, D [0000-0001-9141-5751], Jaecks, P [0000-0002-5878-1327], Jefferies, E [0000-0002-3826-4330], Jesus, LMT [0000-0002-8534-3218], Kambanaros, M [0000-0002-5857-9460], Kang, EK [0000-0001-5315-1361], Khedr, EM [0000-0001-5679-9833], Kong, APH [0000-0002-6211-0358], Kukkonen, T [0000-0002-8189-0337], Laganaro, M [0000-0002-4054-0939], Ralph, MAL [0000-0001-5907-2488], Laska, AC [0000-0002-7330-940X], Leemann, B [0000-0003-2226-6777], Leff, AP [0000-0002-0831-3541], Lima, RR [0000-0002-9914-4789], Lorenz, A [0000-0002-0200-1977], MacWhinney, B [0000-0002-4988-1342], Marshall, RS [0000-0001-9313-5454], Mattioli, F [0000-0002-4912-5520], Maviş, İ [0000-0003-3924-1138], Meinzer, M [0000-0003-1370-3947], Nilipour, R [0000-0003-4180-7989], Noé, E [0000-0002-2547-8727], Paik, NJ [0000-0002-5193-8678], Palmer, R [0000-0002-2335-7104], Papathanasiou, I [0000-0003-0999-696X], Patricio, BF [0000-0002-2619-470X], Martins, IP [0000-0002-9611-7400], Price, C [0000-0003-0111-9364], Jakovac, TP [0000-0002-5018-9556], Rochon, E [0000-0001-5521-0513], Rose, ML [0000-0002-8892-0965], Rosso, C [0000-0001-7236-1508], Rubi-Fessen, I [0000-0002-9775-3812], Ruiter, MB [0000-0001-6147-5235], Snell, C [0000-0001-8606-7801], Stahl, B [0000-0003-3957-1495], Szaflarski, JP [0000-0002-5936-6627], Thomas, SA [0000-0003-0704-9387], van de Sandt-Koenderman, M [0000-0002-8104-6937], van der Meulen, I [0000-0002-6156-3873], Visch-Brink, E [0000-0001-7833-0112], Worrall, L [0000-0002-3283-7038], Wright, HH [0000-0001-6922-6364], and Apollo - University of Cambridge Repository

Subjects
Stroke, IPD, meta-analysis, stroke, aphasia, complex intervention, IPD, meta-analysis, genetic structures, aphasia, complex intervention
Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.\ud \ud Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.\ud \ud Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.\ud \ud Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.\ud \ud Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.\ud \ud Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)

Published
2020

62. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: An individual patient data meta-analysis

Author

Mózes, F.E. Lee, J.A. Selvaraj, E.A. Jayaswal, A.N.A. Trauner, M. Boursier, J. Fournier, C. Staufer, K. Stauber, R.E. Bugianesi, E. Younes, R. Gaia, S. Lupșor-Platon, M. Petta, S. Shima, T. Okanoue, T. Mahadeva, S. Chan, W.-K. Eddowes, P.J. Newsome, P.N. Wong, V.W.-S. de Ledinghen, V. Fan, J. Shen, F. Cobbold, J.F. Sumida, Y. Okajima, A. Schattenberg, J.M. Labenz, C. Kim, W. Lee, M.S. Wiegand, J. Karlas, T. Yılmaz, Y. Aithal, G.P. Palaniyappan, N. Cassinotto, C. Aggarwal, S. Garg, H. Ooi, G.J. Nakajima, A. Yoneda, M. Ziol, M. Barget, N. Geier, A. Tuthill, T. Brosnan, M.J. Anstee, Q.M. Neubauer, S. Harrison, S.A. Bossuyt, P.M. Pavlides, M. Anstee, Q. Daly, A. Johnson, K. Govaere, O. Cockell, S. Tiniakos, D. Bedossa, P. Oakley, F. Cordell, H. Day, C. Wonders, K. Bossuyt, P. Zafarmand, H. Vali, Y. Lee, J. Ratziu, V. Clement, K. Pais, R. Schuppan, D. Schattenberg, J. Schuppan, D. Schattenberg, J. Vidal-Puig, T. Vacca, M. Rodrigues-Cuenca, S. Allison, M. Kamzolas, I. Petsalaki, E. Oresic, M. Hyötyläinen, T. McGlinchey, A. Mato, J.M. Millet, O. Dufour, J.-F. Berzigotti, A. Pavlides, M. Harrison, S. Neubauer, S. Cobbold, J. Mozes, F. Akhtar, S. Banerjee, R. Kelly, M. Shumbayawonda, E. Dennis, A. Erpicum, C. Graham, M. Romero-Gómez, M. Gómez-González, E. Ampuero, J. Castell, J. Gallego-Durán, R. Fernández, I. Montero-Vallejo, R. Karsdal, M. Erhardtsen, E. Rasmussen, D. Leeming, D.J. Fisker, M.J. Sinisi, A. Musa, K. Betsou, F. Sandt, E. Tonini, M. Bugianesi, E. Rosso, C. Armandi, A. Marra, F. Gastaldelli, A. Svegliati, G. Boursier, J. Francque, S. Vonghia, L. Ekstedt, M. Kechagias, S. Yki-Jarvinen, H. Porthan, K. van Mil, S. Papatheodoridis, G. Cortez-Pinto, H. Valenti, L. Petta, S. Miele, L. Geier, A. Trautwein, C. Aithal, G. Hockings, P. Newsome, P. Wenn, D. Rodrigues, C.M.P. Chaumat, P. Hanf, R. Trylesinski, A. Ortiz, P. Duffin, K. Brosnan, J. Tuthill, T. McLeod, E. Ertle, J. Younes, R. Ostroff, R. Alexander, L. Kjær, M.S. Mikkelsen, L.F. Balp, M.-M. Brass, C. Jennings, L. Martic, M. Loeffler, J. Hanauer, G. Shankar, S. Fournier, C. Pepin, K. Ehman, R. Myers, J. Ho, G. Torstenson, R. Myers, R. Doward, L. LITMUS Investigators

Abstract

Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies. Design Individual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated. Biomarkers were assessed individually and in sequential combinations. Results Data were included from 37 primary studies (n=5735; 45% women; median age: 54 years; median body mass index: 30 kg/m2; 33% had type 2 diabetes; 30% had advanced fibrosis). AUROCs of individual LSM-VCTE, FIB-4 and NFS for advanced fibrosis were 0.85, 0.76 and 0.73. Sequential combination of FIB-4 cut-offs (

Published
2021

63. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

Author

Selvaraj, E.A. Mózes, F.E. Jayaswal, A.N.A. Zafarmand, M.H. Vali, Y. Lee, J.A. Levick, C.K. Young, L.A.J. Palaniyappan, N. Liu, C.-H. Aithal, G.P. Romero-Gómez, M. Brosnan, M.J. Tuthill, T.A. Anstee, Q.M. Neubauer, S. Harrison, S.A. Bossuyt, P.M. Pavlides, M. Daly, A. Johnson, K. Govaere, O. Cockell, S. Tiniakos, D. Bedossa, P. Oakley, F. Cordell, H. Day, C. Wonders, K. Bossuyt, P. Zafarmand, H. Lee, J. Ratziu, V. Clement, K. Pais, R. Schuppan, D. Schattenberg, J. Vidal-Puig, T. Vacca, M. Rodrigues-Cuenca, S. Allison, M. Kamzolas, I. Petsalaki, E. Oresic, M. Hyötyläinen, T. McGlinchey, A. Mato, J.M. Millet, O. Dufour, J.-F. Berzigotti, A. Harrison, S. Cobbold, J. Mozes, F. Akhtar, S. Banerjee, R. Kelly, M. Shumbayawonda, E. Dennis, A. Erpicum, C. Gómez-González, E. Ampuero, J. Castell, J. Gallego-Durán, R. Fernández, I. Montero-Vallejo, R. Karsdal, M. Erhardtsen, E. Rasmussen, D. Leeming, D.J. Fisker, M.J. Sinisi, A. Musa, K. Betsou, F. Sandt, E. Tonini, M. Bugianesi, E. Rosso, C. Armandi, A. Marra, F. Gastaldelli, A. Svegliati, G. Boursier, J. Francque, S. Vonghia, L. Ekstedt, M. Kechagias, S. Yki-Jarvinen, H. Luukkonen, P. van Mil, S. Papatheodoridis, G. Cortez-Pinto, H. Valenti, L. Petta, S. Miele, L. Geier, A. Trautwein, C. Aithal, G. Hockings, P. Newsome, P. Wenn, D. Pereira Rodrigues, C.M. Chaumat, P. Hanf, R. Trylesinski, A. Ortiz, P. Duffin, K. Brosnan, J. Tuthill, T. McLeod, E. Ertle, J. Younes, R. Ostroff, R. Alexander, L. Kjær, M.S. Mikkelsen, L.F. Balp, M.-M. Brass, C. Jennings, L. Martic, M. Loeffler, J. Hanauer, G. Shankar, S. Fournier, C. Pepin, K. Ehman, R. Myers, J. Ho, G. Torstenson, R. Myers, R. Doward, L. LITMUS Investigators

Abstract

Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) have been proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH). Methods: PubMED/MEDLINE, EMBASE and the Cochrane Library were searched for studies examining the diagnostic accuracy of these index tests, against histology as the reference standard, in adult patients with NAFLD. Two authors independently screened and assessed methodological quality of studies and extracted data. Summary estimates of sensitivity, specificity and area under the curve (sAUC) were calculated for fibrosis stages and NASH, using a random effects bivariate logit-normal model. Results: We included 82 studies (14,609 patients). Meta-analysis for diagnosing fibrosis stages was possible in 53 VCTE, 11 MRE, 12 pSWE and 4 2DSWE studies, and for diagnosing NASH in 4 MRE studies. sAUC for diagnosis of significant fibrosis were: 0.83 for VCTE, 0.91 for MRE, 0.86 for pSWE and 0.75 for 2DSWE. sAUC for diagnosis of advanced fibrosis were: 0.85 for VCTE, 0.92 for MRE, 0.89 for pSWE and 0.72 for 2DSWE. sAUC for diagnosis of cirrhosis were: 0.89 for VCTE, 0.90 for MRE, 0.90 for pSWE and 0.88 for 2DSWE. MRE had sAUC of 0.83 for diagnosis of NASH. Three (4%) studies reported intention-to-diagnose analyses and 15 (18%) studies reported diagnostic accuracy against pre-specified cut-offs. Conclusions: When elastography index tests are acquired successfully, they have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these index tests cannot be assessed fully as intention-to-diagnose analyses and validation of pre-specified thresholds are lacking. Lay summary: Non-invasive tests that measure liver stiffness or use magnetic resonance imaging (MRI) have been suggested as alternatives to liver biopsy for assessing the severity of liver scarring (fibrosis) and fatty inflammation (steatohepatitis) in patients with non-alcoholic fatty liver disease (NAFLD). In this study, we summarise the results of previously published studies on how accurately these non-invasive tests can diagnose liver fibrosis and inflammation, using liver biopsy as the reference. We found that some techniques that measure liver stiffness had a good performance for the diagnosis of severe liver scarring. © 2021 The Author(s)

Published
2021

64. First-line thrombectomy strategy for anterior large vessel occlusions: Results of the prospective ETIS egistry

Author

Maïer, B. Finitsis, S. Bourcier, R. Papanagiotou, P. Richard, S. Marnat, G. Sibon, I. Dargazanli, C. Arquizan, C. Blanc, R. Piotin, M. Lapergue, B. Consoli, A. Eugene, F. Vannier, S. Saleme, S. Macian, F. Clarençon, F. Rosso, C. Naggara, O. Turc, G. Viguier, A. Cognard, C. Wolff, V. Pop, R. Mazighi, M. Gory, B.

Abstract

Background: The best recanalization strategy for mechanical thrombectomy (MT) remains unknown as no randomized controlled trial has simultaneously evaluated first-line stent retriever (SR) versus contact aspiration (CA) versus the combined approach (SR+CA). Objective: To compare the efficacy and safety profiles of SR, CA, and SR+CA in patients with acute ischemic stroke (AIS) treated by MT. Methods: We analyzed data of the Endovascular Treatment in Ischemic Stroke (ETIS) Registry, a prospective, multicenter, observational study of patients with AIS treated by MT. Patients with M1 and intracranial internal carotid artery (ICA) occlusions between January 2015 and March 2020 in 15 comprehensive stroke centers were included. We assessed the association of first-line strategy with favorable outcomes at 3 months (modified Rankin Scale score 0-2), successful recanalization rates (modified Thrombolysis In Cerebral Infarction (mTICI) 2b/3), and safety outcomes. Results: We included 2643 patients, 406 treated with SR, 1126 with CA, and 1111 with SR+CA. CA or SR+CA achieved more successful recanalization than SR for M1 occlusions (aOR=2.09, (95% CI 1.39 to 3.13) and aOR=1.69 (95% CI 1.12 to 2.53), respectively). For intracranial ICA, SR+CA achieved more recanalization than SR (aOR=2.52 (95% CI 1.32 to 4.81)), no differences were observed between CA and SR+CA. SR+CA was associated with lower odds of favorable outcomes compared with SR (aOR=0.63 (95% CI 0.44 to 0.90)) and CA (aOR=0.71 (95% CI 0.55 to 0.92)), higher odds of mortality at 3 months (aOR=1.56 (95% CI 1.22 to 2.0)) compared with CA, and higher odds of symptomatic intracranial hemorrhage (aOR=1.59 (95% CI 1.1 to 2.3)) compared with CA. Conclusions: Despite high recanalization rates, our results question the safety of the combined approach, which was associated with disability and mortality. Randomized controlled trials are needed to evaluate the efficacy and safety of these techniques. © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Published
2021

65. Predictors of Poststroke Aphasia Recovery

Author

Ali, M., VandenBerg, K., Williams, L., Abo, M., Becker, F., Bowen, A., Brandenburg, C., Breitenstein, C., Bruehl, S., Copland, D., Cranfill, T. B., Pietro-Bachmann, M. di, Enderby, P., Fillingham, J., Lucia Galli, F., Gandolfi, M., Glize, B., Godecke, E., Hawkins, N., Hilari, K., Hinckley, J., Horton, S., Howard, D., Jaecks, P., Jefferies, E., Jesus, L.M.T., Kambanaros, M., Kyoung Kang, E., Khedr, E. M., Pak-Hin Kong, A., Kukkonen, T., Laganaro, M., Lambon Ralph, M. A., Charlotte Laska, A., Leemann, B., Leff, A., Lima, R., Lorenz, A., Mac Whinney, B., Shisler Marshall, R., Mattioli, F., Mavis, I., Meinzer, M., Nilipour, R., Noe, E., Paik, N-J., Palmer, R., Papathanasiou, I., Patrício, B., Pavao Martins, I., Price, C., Prizl Jakovac, T., Rochon, E., Rose, M., Rosso, C., Rubi-Fessen, I., Ruiter, M. B., Snell, C., Stahl, B., Szaflarski, J. P., Thomas, S. A, van de Sandt-Koenderman, M., van der Meulen, I., Visch-Brink, E., Worrall, L., Harris Wright, H., and Brady, M. C.

Subjects
behavioral disciplines and activities, P1, RC
Abstract

Background and Purpose:\ud The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset.\ud \ud Methods:\ud Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level.\ud \ud Results:\ud Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (

Published
2021

66. EP48* Safety and effectiveness of mechanical thrombectomy for primary isolated distal vessel occlusions: a monocentric retrospective comparative study

Author

Elhorany, M, primary, Rosso, C, additional, Shotar, E, additional, Baronnet-Chauvet, F, additional, Premat, K, additional, Lenck, S, additional, Crozier, S, additional, Corcy, C, additional, Bottin, L, additional, Yassin Mansour, O, additional, Ali Tag El-din, E-S, additional, Ahmed Fadel, W, additional, Antoine Sourour, N, additional, Alamowitch, S, additional, Samson, Y, additional, and Clarençon, F, additional

Published
2021
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67. Influenza vaccination during the first 6 months after solid organ transplantation is efficacious and safe

Author

Alamo, J.M., Gasch, A., Gentil-Govantes, M.A., Molina-Ortega, F.J., Lage, E., Martínez-Atienza, J., Sánchez, M., Rosso, C., Arizón, J.M., Aguera, M., Cantisán, S., Montero, J.L., Páez, A., Rodríguez, A., Santos, S., Vidal, E., Berasategui, C., Campins, M., López-Meseguer, M., Saez, B., Marcos, M.A., Sanclemente, G., Diez, N., Goikoetxea, J., Casafont, F., Cobo-Beláustegy, M., Durán, R., Fábrega-García, E., Fernández-Rozas, S., González-Rico, C., Zurbano-Goñi, F., Bodro, M., Niubó, J., Oriol, S., Sabé, N., Anaya, F., Bouza, E., Catalán, P., Diez, P., Eworo, A., Kestler, M., Lopez-Roa, P., Rincón, D., Rodríguez, M., Salcedo, M., Sousa, Y., Valerio, M., Morales-Barroso, I., Aguado, J.M., Origuen, J., Pérez-Romero, P., Bulnes-Ramos, A., Torre-Cisneros, J., Gavaldá, J., Aydillo, T.A., Moreno, A., Montejo, M., Fariñas, M.C., Carratalá, J., Muñoz, P., Blanes, M., Fortún, J., Suárez-Benjumea, A., López-Medrano, F., Barranco, J.L., Peghin, M., Roca, C., Lara, R., and Cordero, E.

Published
2015
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68. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: An individual patient data meta-analysis

Author

Mózes, F.E. Lee, J.A. Selvaraj, E.A. Jayaswal, A.N.A. Trauner, M. Boursier, J. Fournier, C. Staufer, K. Stauber, R.E. Bugianesi, E. Younes, R. Gaia, S. Lupșor-Platon, M. Petta, S. Shima, T. Okanoue, T. Mahadeva, S. Chan, W.-K. Eddowes, P.J. Newsome, P.N. Wong, V.W.-S. de Ledinghen, V. Fan, J. Shen, F. Cobbold, J.F. Sumida, Y. Okajima, A. Schattenberg, J.M. Labenz, C. Kim, W. Lee, M.S. Wiegand, J. Karlas, T. Yılmaz, Y. Aithal, G.P. Palaniyappan, N. Cassinotto, C. Aggarwal, S. Garg, H. Ooi, G.J. Nakajima, A. Yoneda, M. Ziol, M. Barget, N. Geier, A. Tuthill, T. Brosnan, M.J. Anstee, Q.M. Neubauer, S. Harrison, S.A. Bossuyt, P.M. Pavlides, M. Anstee, Q. Daly, A. Johnson, K. Govaere, O. Cockell, S. Tiniakos, D. Bedossa, P. Oakley, F. Cordell, H. Day, C. Wonders, K. Bossuyt, P. Zafarmand, H. Vali, Y. Lee, J. Ratziu, V. Clement, K. Pais, R. Schuppan, D. Schattenberg, J. Schuppan, D. Schattenberg, J. Vidal-Puig, T. Vacca, M. Rodrigues-Cuenca, S. Allison, M. Kamzolas, I. Petsalaki, E. Oresic, M. Hyötyläinen, T. McGlinchey, A. Mato, J.M. Millet, O. Dufour, J.-F. Berzigotti, A. Pavlides, M. Harrison, S. Neubauer, S. Cobbold, J. Mozes, F. Akhtar, S. Banerjee, R. Kelly, M. Shumbayawonda, E. Dennis, A. Erpicum, C. Graham, M. Romero-Gómez, M. Gómez-González, E. Ampuero, J. Castell, J. Gallego-Durán, R. Fernández, I. Montero-Vallejo, R. Karsdal, M. Erhardtsen, E. Rasmussen, D. Leeming, D.J. Fisker, M.J. Sinisi, A. Musa, K. Betsou, F. Sandt, E. Tonini, M. Bugianesi, E. Rosso, C. Armandi, A. Marra, F. Gastaldelli, A. Svegliati, G. Boursier, J. Francque, S. Vonghia, L. Ekstedt, M. Kechagias, S. Yki-Jarvinen, H. Porthan, K. van Mil, S. Papatheodoridis, G. Cortez-Pinto, H. Valenti, L. Petta, S. Miele, L. Geier, A. Trautwein, C. Aithal, G. Hockings, P. Newsome, P. Wenn, D. Rodrigues, C.M.P. Chaumat, P. Hanf, R. Trylesinski, A. Ortiz, P. Duffin, K. Brosnan, J. Tuthill, T. McLeod, E. Ertle, J. Younes, R. Ostroff, R. Alexander, L. Kjær, M.S. Mikkelsen, L.F. Balp, M.-M. Brass, C. Jennings, L and Mózes, F.E. Lee, J.A. Selvaraj, E.A. Jayaswal, A.N.A. Trauner, M. Boursier, J. Fournier, C. Staufer, K. Stauber, R.E. Bugianesi, E. Younes, R. Gaia, S. Lupșor-Platon, M. Petta, S. Shima, T. Okanoue, T. Mahadeva, S. Chan, W.-K. Eddowes, P.J. Newsome, P.N. Wong, V.W.-S. de Ledinghen, V. Fan, J. Shen, F. Cobbold, J.F. Sumida, Y. Okajima, A. Schattenberg, J.M. Labenz, C. Kim, W. Lee, M.S. Wiegand, J. Karlas, T. Yılmaz, Y. Aithal, G.P. Palaniyappan, N. Cassinotto, C. Aggarwal, S. Garg, H. Ooi, G.J. Nakajima, A. Yoneda, M. Ziol, M. Barget, N. Geier, A. Tuthill, T. Brosnan, M.J. Anstee, Q.M. Neubauer, S. Harrison, S.A. Bossuyt, P.M. Pavlides, M. Anstee, Q. Daly, A. Johnson, K. Govaere, O. Cockell, S. Tiniakos, D. Bedossa, P. Oakley, F. Cordell, H. Day, C. Wonders, K. Bossuyt, P. Zafarmand, H. Vali, Y. Lee, J. Ratziu, V. Clement, K. Pais, R. Schuppan, D. Schattenberg, J. Schuppan, D. Schattenberg, J. Vidal-Puig, T. Vacca, M. Rodrigues-Cuenca, S. Allison, M. Kamzolas, I. Petsalaki, E. Oresic, M. Hyötyläinen, T. McGlinchey, A. Mato, J.M. Millet, O. Dufour, J.-F. Berzigotti, A. Pavlides, M. Harrison, S. Neubauer, S. Cobbold, J. Mozes, F. Akhtar, S. Banerjee, R. Kelly, M. Shumbayawonda, E. Dennis, A. Erpicum, C. Graham, M. Romero-Gómez, M. Gómez-González, E. Ampuero, J. Castell, J. Gallego-Durán, R. Fernández, I. Montero-Vallejo, R. Karsdal, M. Erhardtsen, E. Rasmussen, D. Leeming, D.J. Fisker, M.J. Sinisi, A. Musa, K. Betsou, F. Sandt, E. Tonini, M. Bugianesi, E. Rosso, C. Armandi, A. Marra, F. Gastaldelli, A. Svegliati, G. Boursier, J. Francque, S. Vonghia, L. Ekstedt, M. Kechagias, S. Yki-Jarvinen, H. Porthan, K. van Mil, S. Papatheodoridis, G. Cortez-Pinto, H. Valenti, L. Petta, S. Miele, L. Geier, A. Trautwein, C. Aithal, G. Hockings, P. Newsome, P. Wenn, D. Rodrigues, C.M.P. Chaumat, P. Hanf, R. Trylesinski, A. Ortiz, P. Duffin, K. Brosnan, J. Tuthill, T. McLeod, E. Ertle, J. Younes, R. Ostroff, R. Alexander, L. Kjær, M.S. Mikkelsen, L.F. Balp, M.-M. Brass, C. Jennings, L

Abstract

Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies. Design Individual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated. Biomarkers were assessed individually and in sequential combinations. Results Data were included from 37 primary studies (n=5735; 45% women; median age: 54 years; median body mass index: 30 kg/m2; 33% had type 2 diabetes; 30% had advanced fibrosis). AUROCs of individual LSM-VCTE, FIB-4 and NFS for advanced fibrosis were 0.85, 0.76 and 0.73. Sequential combination of FIB-4 cut-offs (<1.3; ≥2.67) followed by LSM-VCTE cut-offs (<8.0; ≥10.0 kPa) to rule-in or rule-out advanced fibrosis had sensitivity and specificity (95% CI) of 66% (63-68) and 86% (84-87) with 33% needing a biopsy to establish a final diagnosis. FIB-4 cut-offs (<1.3; ≥3.48) followed by LSM cut-offs (<8.0; ≥20.0 kPa) to rule out advanced fibrosis or rule in cirrhosis had a sensitivity of 38% (37-39) and specificity of 90% (89-91) with 19% needing biopsy. Conclusion Sequential combinations of markers with a lower cut-off to rule-out advanced fibrosis and a higher cut-off to rule-in cirrhosis can reduce the need for liver biopsies. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Published
2021

69. Drought impact in the Bolivian Altiplano agriculture associated with the El Niño–Southern Oscillation using satellite imagery data

Author

Canedo-Rosso, C., Hochrainer-Stigler, S., Pflug, G., Condori, B., Berndtsson, R., Canedo-Rosso, C., Hochrainer-Stigler, S., Pflug, G., Condori, B., and Berndtsson, R.

Abstract

Drought is a major natural hazard in the Bolivian Altiplano that causes large agricultural losses. However, the drought effect on agriculture varies largely on a local scale due to diverse factors such as climatological and hydrological conditions, sensitivity of crop yield to water stress, and crop phenological stage among others. To improve the knowledge of drought impact on agriculture, this study aims to classify drought severity using vegetation and land surface temperature data, analyse the relationship between drought and climate anomalies, and examine the spatio-temporal variability of drought using vegetation and climate data. Empirical data for drought assessment purposes in this area are scarce and spatially unevenly distributed. Due to these limitations we used vegetation, land surface temperature (LST), precipitation derived from satellite imagery, and gridded air temperature data products. Initially, we tested the performance of satellite precipitation and gridded air temperature data on a local level. Then, the normalized difference vegetation index (NDVI) and LST were used to classify drought events associated with past El Niño–Southern Oscillation (ENSO) phases. It was found that the most severe drought events generally occur during a positive ENSO phase (El Niño years). In addition, we found that a decrease in vegetation is mainly driven by low precipitation and high temperature, and we identified areas where agricultural losses will be most pronounced under such conditions. The results show that droughts can be monitored using satellite imagery data when ground data are scarce or of poor data quality. The results can be especially beneficial for emergency response operations and for enabling a proactive approach to disaster risk management against droughts.

Published
2021

70. Increased serum ferritin levels predict long-term mortality in patients with NAFLD

Author

Armandi, A., primary, Younes, R., additional, Caviglia, G.P., additional, Petta, S., additional, Miele, L., additional, Rosso, C., additional, Pennisi, G., additional, Francione, P., additional, Liguori, A., additional, Govaere, O., additional, Fracanzani, A.L., additional, Eslam, M., additional, Valenti, L., additional, George, J., additional, Anstee, Q.M., additional, and Bugianesi, E., additional

Published
2021
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77. RELEASE. Communicating simply, but not too simply. Reporting of participants and speech and language interventions for aphasia after stroke

Author

Brady, M. C., Ali, M., VandenBerg, K., Williams, L. J., Williams, L., Abo, M., Becker, F., Bowen, A., Brandenburg, C., Breitenstein, C., Bruehl, S., Copland, D., Cranfill, T. B., di Pietro-Bachmann, M., Enderby, P., Fillingham, J., Galli, F., Gandolfi, M., Glize, B., Godecke, E., Hawkins, N., Hilari, K., Hinckley, J., Horton, S., Howard, D., Jaecks, P., Jefferies, E., Jesus, L.M.T., Kambanaros, M., Kang, E. K., Khedr, E. M., Kong, A. P., Kukkonen, T., Laganaro, M., Lambon-Ralph, M. A., Laska, A., Leemann, B., Leff, A. P., Lima, R. R., Lorenz, A., MacWhinney, B., Marshall, R. S., Mattioli, F., Mavis, I., Meinzer, M., Nilipour, R., Noe, E., Paik, N-J., Palmer, R., Papathanasiou, I., Patrício, B., Martins, I., Price, C., Jakovac, T. P., Rochon, E., Rose, M., Rosso, C., Rubi-Fessen, I., Ruiter, M. B., Snell, C., Stahl, B., Szaflarski, J. P., Thomas, S. A., van de Sandt-Koenderman, M., van der Meulen, I., Visch-Brink, E., Worrall, L., Wright, H. H., Tampere University, Department of Neurosciences and Rehabilitation, Welfare Sciences, and RELEASE Collaboration

Subjects
medicine.medical_specialty, Speech-Language Pathology, 515 Psychology, Applied psychology, Psychological intervention, Context (language use), Language and Linguistics, 3124 Neurology and psychiatry, Language and Speech, Learning and Therapy, Speech and Hearing, complex interventions, Intervention (counseling), Aphasia, medicine, Humans, Uncategorized, Research and Theory, Stroke Rehabilitation, Secondary data, speech and language therapy, Guideline, LPN and LVN, stroke, Checklist, aphasia, Language & Communication, P1, Stroke, Otorhinolaryngology, medicine.symptom, Psychology, RC
Abstract

© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Purpose: Speech and language pathology (SLP) for aphasia is a complex intervention delivered to a heterogeneous population within diverse settings. Simplistic descriptions of participants and interventions in research hinder replication, interpretation of results, guideline and research developments through secondary data analyses. This study aimed to describe the availability of participant and intervention descriptors in existing aphasia research datasets. Method: We systematically identified aphasia research datasets containing ≥10 participants with information on time since stroke and language ability. We extracted participant and SLP intervention descriptions and considered the availability of data compared to historical and current reporting standards. We developed an extension to the Template for Intervention Description and Replication checklist to support meaningful classification and synthesis of the SLP interventions to support secondary data analysis. Result: Of 11, 314 identified records we screened 1131 full texts and received 75 dataset contributions. We extracted data from 99 additional public domain datasets. Participant age (97.1%) and sex (90.8%) were commonly available. Prior stroke (25.8%), living context (12.1%) and socio-economic status (2.3%) were rarely available. Therapy impairment target, frequency and duration were most commonly available but predominately described at group level. Home practice (46.3%) and tailoring (functional relevance 46.3%) were inconsistently available. Conclusion : Gaps in the availability of participant and intervention details were significant, hampering clinical implementation of evidence into practice and development of our field of research. Improvements in the quality and consistency of participant and intervention data reported in aphasia research are required to maximise clinical implementation, replication in research and the generation of insights from secondary data analysis. Systematic review registration: PROSPERO CRD42018110947.

Published
2020
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78. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Author

Govaere, O. Cockell, S. Tiniakos, D. Queen, R. Younes, R. Vacca, M. Alexander, L. Ravaioli, F. Palmer, J. Petta, S. Boursier, J. Rosso, C. Johnson, K. Wonders, K. Day, C.P. Ekstedt, M. Orešič, M. Darlay, R. Cordell, H.J. Marra, F. Vidal-Puig, A. Bedossa, P. Schattenberg, J.M. Clément, K. Allison, M. Bugianesi, E. Ratziu, V. Daly, A.K. Anstee, Q.M.

Abstract

The mechanisms that drive nonalcoholic fatty liver disease (NAFLD) remain incompletely understood. This large multicenter study characterized the transcriptional changes that occur in liver tissue across the NAFLD spectrum as disease progresses to cirrhosis to identify potential circulating markers. We performed high-throughput RNA sequencing on a discovery cohort comprising histologically characterized NAFLD samples from 206 patients. Unsupervised clustering stratified NAFLD on the basis of disease activity and fibrosis stage with differences in age, aspartate aminotransferase (AST), type 2 diabetes mellitus, and carriage of PNPLA3 rs738409, a genetic variant associated with NAFLD. Relative to early disease, we consistently identified 25 differentially expressed genes as fibrosing steatohepatitis progressed through stages F2 to F4. This 25-gene signature was independently validated by logistic modeling in a separate replication cohort (n = 175), and an integrative analysis with publicly available single-cell RNA sequencing data elucidated the likely relative contribution of specific intrahepatic cell populations. Translating these findings to the protein level, SomaScan analysis in more than 300 NAFLD serum samples confirmed that circulating concentrations of proteins AKR1B10 and GDF15 were strongly associated with disease activity and fibrosis stage. Supporting the biological plausibility of these data, in vitro functional studies determined that endoplasmic reticulum stress up-regulated expression of AKR1B10, GDF15, and PDGFA, whereas GDF15 supplementation tempered the inflammatory response in macrophages upon lipid loading and lipopolysaccharide stimulation. This study provides insights into the pathophysiology of progressive fibrosing steatohepatitis, and proof of principle that transcriptomic changes represent potentially tractable and clinically relevant markers of disease progression. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

Published
2020

81. The Rosat All-Sky Survey Bright Source Catalog

Author

Voges, W., Aschenbach, B., Boller, Th., Bräuninger, H., Briel, U., Burkert, W., Dennerl, K., Englhauser, J., Gruber, R., Haberl, F., Hartner, G., Hasinger, G., Kürster, M., Pfeffermann, E., Pietsch, W., Predehl, P., Rosso, C., Schmitt, J. H. M. M., Trümper, J., Zimmermann, U., McLean, Brian J., editor, Golombek, Daniel A., editor, Hayes, Jeffrey J. E., editor, and Payne, Harry E., editor

Published
1998
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83. RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author

Brady, M. C., Ali, M., VandenBerg, K., Williams, L. J., Williams, L. R., Abo, M., Becker, F., Bowen, A., Brandenburg, C., Breitenstein, C., Bruehl, S., Copland, D., Cranfill, T. B., de Pietro-Bachmann, M., Enderby, P., Fillingham, J., Galli, F., Gandolfi, M., Glize, B., Godecke, E., Hawkins, N., Hilari, K., Hinckley, J., Horton, S., Howard, D., Jaecks, P., Jefferies, E., Jesus, L.M.T., Kambanaros, M., Laganaro, M., Lambon Ralph, M. A., Laska, A., Leemann, B., Leff, A.P., Lima, R., Lorenz, A., MacWhinney, B., Shisler Marshall, R., Mattioli, F., Mavis, I., Meinzer, M., Nilipour, R., Noe, E., Paik, N-J., Palmer, R., Papathanasiou, I., Patrício, B., Pavao Martins, I., Price, C. J., Prizl Jakovac, T., Rochon, E., Rose, M., Rosso, C., Rubi-Fessen, I., Ruiter, M. B., Snell, C., Stahl, B., Szaflarski, J., Thomas, S., van de Sandt-Koenderman, M., van der Meulen, I., Visch-Brink, E., Worrall, L., and Harris Wright, H.

Subjects
P1
Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. \ud \ud Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.\ud \ud Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use metaand network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.\ud \ud Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.\ud \ud Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.\ud \ud Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947

Published
2019

85. Presence of Serum Antinuclear Antibodies Does Not Impact Long-Term Outcomes in Nonalcoholic Fatty Liver Disease

Author

Younes, R., Govaere, O., Petta, S., Miele, Luca, Tiniakos, D., Burt, A., David, E., Vecchio, Fabio Maria, Maggioni, M., Cabibi, D., Fracanzani, A. L., Rosso, C., Blanco, M. J. G., Armandi, A., Caviglia, G. P., Zaki, M. Y. W., Liguori, Antonio, Francione, P., Pennisi, G., Grieco, Antonio, Valenti, L., Anstee, Q. M., Bugianesi, E., Miele L. (ORCID:0000-0003-3464-0068), Vecchio F. M. (ORCID:0000-0002-9197-2264), Liguori A., Grieco A. (ORCID:0000-0002-0544-8993), Younes, R., Govaere, O., Petta, S., Miele, Luca, Tiniakos, D., Burt, A., David, E., Vecchio, Fabio Maria, Maggioni, M., Cabibi, D., Fracanzani, A. L., Rosso, C., Blanco, M. J. G., Armandi, A., Caviglia, G. P., Zaki, M. Y. W., Liguori, Antonio, Francione, P., Pennisi, G., Grieco, Antonio, Valenti, L., Anstee, Q. M., Bugianesi, E., Miele L. (ORCID:0000-0003-3464-0068), Vecchio F. M. (ORCID:0000-0002-9197-2264), Liguori A., and Grieco A. (ORCID:0000-0002-0544-8993)

Abstract

INTRODUCTION: We investigated the longitudinal impact of antinuclear antibody (ANA) on clinical outcomes and survival in nonalcoholic fatty liver disease (NAFLD). METHODS: ANA were found in 16.9% of 923 biopsy-proven NAFLD patients, but none of them had histologic autoimmune hepatitis (AIH) or developed AIH after a mean follow-up of 106±50 months. RESULTS: Although ANA-positive cases had a higher prevalence of nonalcoholic steatohepatitis at baseline, the occurrence of liver-related events, hepatocellula carcinoma, cardiovascular events, extrahepatic malignancy, and overall survival were similar to ANA-negative. DISCUSSION: Once AIH has been ruled out, the long-term outcomes and survival are unaffected by the presence of ANA in patients with NAFLD.

Published
2020

87. The Rosat All-Sky Survey Bright Source Catalog

Author

Voges, W., primary, Aschenbach, B., additional, Boller, Th., additional, Bräuninger, H., additional, Briel, U., additional, Burkert, W., additional, Dennerl, K., additional, Englhauser, J., additional, Gruber, R., additional, Haberl, F., additional, Hartner, G., additional, Hasinger, G., additional, Kürster, M., additional, Pfeffermann, E., additional, Pietsch, W., additional, Predehl, P., additional, Rosso, C., additional, Schmitt, J. H. M. M., additional, Trümper, J., additional, and Zimmermann, U., additional

Published
1997
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92. Risk of developing hepatocellular carcinoma (HCC) in patients with cirrhosis of viral etiology evaluated by the association of alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist-II (PIVKA-II) and glypican-3 (GPC-3)

Author

Caviglia, G.P., primary, Abate, M.L., additional, Ciruolo, M., additional, Carucci, P., additional, Olivero, A., additional, Rolle, E., additional, Rosso, C., additional, Younes, R., additional, Ciancio, A., additional, Smedile, A., additional, Saracco, G.M., additional, Bugianesi, E., additional, and Gaia, S., additional

Published
2020
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93. Interplay between metabolic derangement, hepatic fibrogenesis and macrophage activation in non-diabetic patients with non-alcoholic fatty liver disease

Author

Rosso, C., primary, Younes, R., additional, Leeming, D.J., additional, Surabattula, R., additional, Caviglia, G.P., additional, Gaggini, M., additional, Armandi, A., additional, Olivero, A., additional, Abate, M.L., additional, Gastaldelli, A., additional, Schuppan, D., additional, and Bugianesi, E., additional

Published
2020
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95. Rivaroxaban for stroke prevention after embolic stroke of undetermined source

Author

Hart, Robert G, Sharma, Mukul, Mundl, Hardi, Kasner, Scott E, Bangdiwala, Shrikant I, Berkowitz, Scott D, Swaminathan, Balakumar, Lavados, Pablo, Wang, Yongjun, Wang, Yilong, Davalos, Antonio, Shamalov, Nikolay, Mikulik, Robert, Cunha, Luis, Lindgren, Arne, Arauz, Antonio, Lang, Wilfried, Czlonkowska, Anna, Eckstein, Jens, Gagliardi, Rubens J, Amarenco, Pierre, Ameriso, Sebastian F, Tatlisumak, Turgut, Veltkamp, Roland, Hankey, Graeme J, Toni, Danilo, Bereczki, Daniel, Uchiyama, Shinichiro, Ntaios, George, Yoon, Byung-Woo, Brouns, Raf, Endres, Matthias, Muir, Keith W, Bornstein, Natan, Ozturk, Serefnur, O'Donnell, Martin J, De Vries Basson, Matthys M, Pare, Guillaume, Pater, Calin, Kirsch, Bodo, Sheridan, Patrick, Peters, Gary, Weitz, Jeffrey I, Peacock, W Frank, Shoamanesh, Ashkan, Benavente, Oscar R, Joyner, Campbell, Themeles, Ellison, Connolly, Anderson DC, Stuart J., Demets, Dl, Kaste, M, Norrving, B, Wyse, Dg, Alet, M, Allende, G, Beinlich, A, Berrios, W, Bruera, G, Castro, D, Chialvo, L, Claverie, S, Contardo, L, Couto, J, Deganutto, R, Diaz, R, Dossi, D, Esnaola, M, Falco, M, Fernandez Pirrone, P, Ferrari, J, Firstenfeld, A, Galli Giqueauk, E, Gilli, M, Gonzalez, L, Gonzalez Toledo, M, Grecco, M, Halac, B, Hawkes, M, Ioli, P, Jure, L, Klein, F, Lepera, S, Lujan, S, Mackinnon, F, Marroquin, M, Martin, J, Parisi, V, Perez Leguizamon, P, Persi, G, Povedano, P, Povedano, G, Pujol Lereis, V, Radrizzani, L, Reich, E, Repetto, M, Rodriguez Lucci, F, Romano, M, Saredo, G, Schneider, M, Simonsini, C, Sumay, G, Thomson, A, Toledo, W, Torres, C, Vila, A, Abdul Rasheed, N, Anderson, C, Bailey, P, Blacker, D, Carcel, C, Clissold, B, Delcourt, C, Field, D, Gangadharan, S, Ghia, D, Kleinig, T, Leyden, J, Ly, J, Ma, H, Mackey, E, Mishra, S, Moey, A, Musuka, T, Pepper, E, Phan, T, Sabet, A, Saw, J, Singh, B, Tryambake, D, Tu, H, Wijeratne, T, Wong, A, Augustin, S, Esterbauer, M, Garnauf, M, Gasiorek, K, Gasser, S, Gaugg, M, Greisenegger, S, Harrasser, M, Heine, M, Huber, 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S, Gunathilagan, G, Gutierrez, R, Guyler, P, Hargroves, D, Harkness, K, Harvey, M, Hayhoe, H, Hicken, L, Hussain, M, Kelly, S, Lam, M, Lindert, R, Louw, S, Luder, R, Macleod, M, Majid, A, Mangion, D, Markova, S, Markus, H, Marsh, R, Mcarthur, K, Menon, N, Metcalf, K, Minhas, J, Minns, M, Mistri, A, Moreton, F, Mpelembue, M, Muddegowda, G, Mudhar, O, Musarrat, K, Myint, M, Natarajan, I, Naylor, D, Ngeh, J, Papavasileiou, V, Perry, R, Piechowski-Jozwiak, B, Pradhan, M, Rani, A, Rashed, K, Robinson, T, Roffe, C, Saksena, R, Sattar, N, Sekaran, L, Selvarajah, J, Shah, S, Sinha, D, Sivakumar, R, Sztriha, L, Walters, D, Webb, T, Werring, D, Whiteley, W, Whiting, R, Abdelhamid, N, Abdul Rahman, D, Amin, H, Androulakis, M, Babikian, V, Baker, M, Barker Trejo, S, Benjamin, A, Birnbaum, L, Burke, J, Chen, S, Clark, W, Coull, B, De Havenon, A, Dearborn, J, Degeorgia, M, Essa, B, Fares, M, Favate, A, Furlan, A, Gebreyohanns, M, Goddeau, R, Green, D, Greer, D, Haralur Sreekantaiah, Y, Hasan, R, Hedna, V, Henninger, N, Holmstedt, C, Ishida, K, Jagolino, A, Johnson, M, Jun-Oconnell, A, Kaur, S, Khanna, A, Kirshner, H, Kittner, S, Kleindorfer, D, Leira, E, Loomis, C, Lord, A, Lowenkopf, T, Lutsep, H, Magadan, A, Majjhoo, A, Maud, A, Mayasi, Y, Mccullough, L, Mckinney, J, Mehta, S, Mehta, D, Mehta, B, Messe, S, Miller, B, Milling, T, Moonis, M, Navaratnam, D, Okpala, M, Patel, N, Pettigrew, L, Phinney, T, Ramos-Estebanez, C, Rasmussen, J, Rodriguez, G, Rybinnik, I, Santiago, P, Sarraj, A, Savitz, S, Sawyer, R, Scandura, T, Schindler, J, Sen, S, Shang, T, Sharrief, A, Sila, C, Simpkins, A, Sundararajan, S, Talahma, M, Tayal, A, Thaler, D, Tirschwell, D, Torres, J, Vora, N, Warnack, W, Waters, M, Wilson, C, Xiong, W, Zweifler, R, Zanferrari, C., St Marys Development Trust, Servicio de Neurologia (SANTIAGO - Neurologie), Universidad del Desarrollo, Department of Neurology (Dep Neuro - BEIJING), Tiantan Hospital, Neurology department, Universidade de Coimbra [Coimbra], Department of Internal Medicine, University Hospital Basel [Basel], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Neurological Sciences, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Department of Neurology, Seoul National University Hospital, Institute of Neurosciences and Psychology [Glasgow], University of Glasgow, Neurology Department, Ichilov Medical Center, CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Yperzeele, Laetitia, NAVIGATE ESUS Investigators, and Selçuk Üniversitesi

Subjects
Stroke/etiology, Male, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Brain Ischemia, Brain ischemia, 0302 clinical medicine, DESIGN, Rivaroxaban, Hemorrhage/chemically induced, Secondary Prevention, Medicine, Factor Xa Inhibitors/adverse effects, Stroke, Rivaroxaban/adverse effects, ComputingMilieux_MISCELLANEOUS, 11 Medical and Health Sciences, Aspirin, Atrial fibrillation, General Medicine, FORAMEN OVALE CLOSURE, Middle Aged, TRIALS, Intracranial Embolism, SAFETY, Aged, Factor Xa Inhibitors, Female, Hemorrhage, Humans, Platelet Aggregation Inhibitors, Medicine (all), Cardiology, Foramen ovale closure, Platelet aggregation inhibitor, Settore MED/26 - Neurologia, Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Platelet Aggregation Inhibitors/adverse effects, ANTITHROMBOTIC THERAPY, Aspirin/adverse effects, WARFARIN, 03 medical and health sciences, Secondary Prevention/methods, Medicine, General & Internal, Internal medicine, Intracranial Embolism/drug therapy, General & Internal Medicine, NAVIGATE ESUS Investigators, METAANALYSIS, Science & Technology, CRYPTOGENIC STROKE, business.industry, Warfarin, medicine.disease, EFFICACY, ATRIAL-FIBRILLATION, Human medicine, business, Brain Ischemia/prevention & control, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

WOS: 000434263000007, PubMed: 29766772, BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a lower risk of recurrent stroke than aspirin. METHODS We compared the efficacy and safety of rivaroxaban (at a daily dose of 15 mg) with aspirin (at a daily dose of 100 mg) for the prevention of recurrent stroke in patients with recent ischemic stroke that was presumed to be from cerebral embolism but without arterial stenosis, lacune, or an identified cardioembolic source. The primary efficacy outcome was the first recurrence of ischemic or hemorrhagic stroke or systemic embolism in a time-to-event analysis; the primary safety outcome was the rate of major bleeding. RESULTS A total of 7213 participants were enrolled at 459 sites; 3609 patients were randomly assigned to receive rivaroxaban and 3604 to receive aspirin. Patients had been followed for a median of 11 months when the trial was terminated early because of a lack of benefit with regard to stroke risk and because of bleeding associated with rivaroxaban. The primary efficacy outcome occurred in 172 patients in the rivaroxaban group (annualized rate, 5.1%) and in 160 in the aspirin group (annualized rate, 4.8%) (hazard ratio, 1.07; 95% confidence interval [CI], 0.87 to 1.33; P=0.52). Recurrent ischemic stroke occurred in 158 patients in the rivaroxaban group (annualized rate, 4.7%) and in 156 in the aspirin group (annualized rate, 4.7%). Major bleeding occurred in 62 patients in the rivaroxaban group (annualized rate, 1.8%) and in 23 in the aspirin group (annualized rate, 0.7%) (hazard ratio, 2.72; 95% CI, 1.68 to 4.39; P, BayerBayer AG; Janssen Research and Development, Supported by Bayer and Janssen Research and Development.

Published
2018
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96. PF757 REDUCED INTENSITY CONDITIONING AND AVOIDING USE OF BROAD SPECTRUM ANTIBIOTHERAPY ACTIVE AGAINST GRAM-NEGATIVE BACTERIA MIGHT HAVE A CUMULATIVE IMPACT IN REDUCING INTESTINAL MICROBIOTA MISBALANCE

Author

Espigado, I., primary, Rodriguez, N., additional, Labrador, G., additional, Jiménez, S., additional, Aguilar, M., additional, Solano, C., additional, Falantes, J., additional, Vazquez, L., additional, Fernández, C., additional, Kwon, M., additional, Limon, M.C., additional, Márquez-Maraver, F., additional, Fernandez, O., additional, Perez, A., additional, Garcia, I., additional, Cabero, A., additional, Dorado, N., additional, Cordero, J., additional, Molina, J., additional, Montero, M.I., additional, Gonzalez, J., additional, Rosso, C., additional, Pachón, J., additional, Pérez-Simón, J.A., additional, and Ibañez, M.E. Pachón, additional

Published
2019
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100. Longitudinal prognostic value of the most common algorithms for fibrosis in non-alcoholic fatty liver disease: An international study in non-cirrhotic, biopsy-proven patients

Author

Younes, R, Rosso, C, Blanco, Mjg, Petta, S, Miele, Luca, Liguori, Antonio, Francione, P, Fracanzani, Al, Valenti, L, Anstee, Q, Bugianesi, E, Miele, L (ORCID:0000-0003-3464-0068), Liguori, A, Younes, R, Rosso, C, Blanco, Mjg, Petta, S, Miele, Luca, Liguori, Antonio, Francione, P, Fracanzani, Al, Valenti, L, Anstee, Q, Bugianesi, E, Miele, L (ORCID:0000-0003-3464-0068), and Liguori, A

Abstract

n/a

Published
2019

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