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Although halogen bonds share many similarities with hydrogen bonds, they have so far found virtually no application in organic synthesis. This account summarizes our efforts to use multidentate halogen-bond donors (halogen-based Lewis acids) in formal halide abstraction reactions. Following a first proof-of-principle study, we recently reported the first halogen-bond-based organocatalytic carbon-carbon bond-forming reaction. [ABSTRACT FROM AUTHOR]

Cu II catalyst is less efficient at room temperature for C-S cross-coupling. C-S cross-coupling by Cu II catalyst at room temperature is not reported; however, doping of copper with molybdenum metal has been realized here to be more efficient for C-S cross-coupling in comparison to general Cu II catalyst. The doped catalyst CuMoO 4 nanoparticle is found to be more efficient than copper. The catalyst works under mild conditions without any ligand at room temperature and is recyclable and effective for a wide range of thiols and haloarenes (ArI, ArBr, ArF) from milligram to gram scale. The copper-based bimetallic catalyst is developed and recognized for C-S cross-coupling of haloarenes with alkyl and aryl thiols., (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

C(sp)-H Bond activation of acetylene molecule still remains a challenge for synthetic organic chemists. In practice, acetylenes are activated by strong bases and metals. The first example for activating acetylenic protons under base and metal-free conditions is reported here. It involves a general method for synthesizing propargylic derivatives of cotarnine. An array of tetrahydroisoquinolines alkaloids was synthesized by C(sp)-H bond activation of aromatic acetylenes with cotarnine at room temperature. A DFT-based mechanism is proposed for the reaction., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

CuO nanoparticles catalyze the C-N cross coupling of amines with iodobenzene in excellent yields. The reaction is simple and efficient and operates under air with ligand free conditions. The catalyst is recyclable without loss of activity.